It’s generally more expensive to depart on a Wednesday, if you have to leave on this day you can still search on Cheapflights to find great options that meet your needs.
Flights from Medford to Queretaro lean towards being more expensive in December. Prices are generally better when you fly from Medford to Queretaro in September, with the cheapest ticket starting at $178.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Medford to Queretaro as you normally would.