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$203+ Cheap flights from Spartanburg, SC to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/20. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — PTY
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Spartanburg to Panama

Cheapest flights from Spartanburg to Panama
Explore the most affordable flight options available from Spartanburg to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:22 amCLT - PTY
1 stop13h 16mUnited Airlines
Thu 12/2511:35 amPTY - CLT
1 stop10h 07mUnited Airlines
Deal found 12/17$586
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:22 amCLT - PTY
1 stop13h 16mUnited Airlines
Tue 1/610:00 amPTY - CLT
1 stop11h 16mUnited Airlines
Deal found 12/17$678
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1911:38 amCLT - PTY
1 stop8h 21mDelta
Tue 12/238:00 amPTY - CLT
1 stop10h 13mDelta
Deal found 12/16$687
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/169:45 pmCLT - PTY
1 stop16h 02mAmerican Airlines
Mon 12/222:53 pmPTY - CLT
1 stop17h 18mAmerican Airlines
Deal found 12/15$713
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3010:45 pmCLT - PTY
1 stop15h 08mAmerican Airlines
Tue 1/64:31 pmPTY - CLT
1 stop16h 48mAmerican Airlines
Deal found 12/16$743
This Mytrip deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/269:34 pmCLT - PTY
3 stops21h 21mMultiple Airlines
Tue 12/3011:25 amPTY - CLT
3 stops32h 44mMultiple Airlines
Deal found 12/17$748
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2611:24 amCLT - PTY
1 stop27h 21mUnited Airlines
Tue 12/304:41 pmPTY - CLT
1 stop29h 01mUnited Airlines
Deal found 12/16$794
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:11 amCLT - PTY
1 stop6h 42mAmerican Airlines
Tue 12/304:55 pmPTY - CLT
1 stop15h 16mAmerican Airlines
Deal found 12/17$795

Find flight deals from Spartanburg to Panama

Keep the following information in mind while searching for Spartanburg to Panama flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$428
(Avianca Connect)

One-way from

$203
(Avianca Connect)

Popular in

December

Cheapest in

September

Average price

$727
Provider with most accurate pricing for Charlotte Douglas-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charlotte Douglas-Panama City Tocumen Intl flights.
Search Deals
From Spartanburg to Panama
Search Deals
One-way flight from Spartanburg to Panama
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($77 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Spartanburg to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Spartanburg to Panama that are best for you.

Fly from

Spartanburg

Fly to

Panama

Route

Depart

Return

Price

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Fri 1/30

7:00 am-12:40 am

2 stops17h 40m

Panama City Tocumen Intl

Fri 2/6

2:55 pm-12:22 pm

2 stops21h 27m

$444

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sun 2/15

7:00 am-1:00 am

2 stops18h 00m

Panama City Tocumen Intl

Thu 2/19

5:50 pm-12:20 pm

2 stops18h 30m

$463

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 4/14

5:30 am-12:55 pm

1 stop8h 25m

Panama City Tocumen Intl

Wed 4/22

2:20 pm-8:38 am

1 stop17h 18m

$468

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 4/16

6:23 am-4:12 pm

1 stop10h 49m

Panama City Tocumen Intl

Wed 4/22

10:00 am-9:40 pm

1 stop10h 40m

$468

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 4/15

5:30 am-12:55 pm

1 stop8h 25m

Panama City Tocumen Intl

Tue 4/28

2:20 pm-8:38 am

1 stop17h 18m

$468

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sun 2/1

7:00 am-1:00 am

2 stops18h 00m

Panama City Tocumen Intl

Sun 2/8

2:55 pm-12:22 pm

2 stops21h 27m

$470

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sun 2/15

4:50 pm-5:07 pm

1 stop24h 17m

Panama City Tocumen Intl

Thu 2/19

4:41 pm-10:47 am

1 stop18h 06m

$477

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 5/9

6:30 am-4:12 pm

1 stop10h 42m

Panama City Tocumen Intl

Mon 5/11

10:00 am-9:52 pm

1 stop10h 52m

$488

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 2/26

6:33 am-7:38 pm

1 stop13h 05m

Panama City Tocumen Intl

Sun 3/1

4:41 pm-10:47 am

1 stop18h 06m

$488

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 4/20

6:23 am-2:14 pm

1 stop8h 51m

Panama City Tocumen Intl

Sun 4/26

9:45 am-9:07 pm

1 stop10h 22m

$488

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 16 results
1
2

Best time to book a flight from Spartanburg to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Panama

What is the cheapest month to book a flight from Spartanburg to Panama?

Currently, August is the cheapest month in which you can book a flight from Spartanburg to Panama (average of $267). Flying from Spartanburg to Panama in January is currently the most expensive (average of $435). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to PA?

Find hourly flight availability from Spartanburg to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 32% on flights from Spartanburg to Panama by exploring options for tickets at noon.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated December 18, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Spartanburg to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,005 reviews

Crew

8.5

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,005 reviews
Delta
7.9
Good
8,005 reviews

Crew

8.5

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,091 reviews
Delta
7.9
Good
8,005 reviews

Crew

8.5

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,005 reviews

Crew

8.5

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Spartanburg to Panama?

    Departing from Spartanburg to Panama will take you 8h 25m. Spartanburg and Panama are separated by a distance of 1808 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Spartanburg to Panama that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Panama.

  • Can I find deals for business class flights from Spartanburg to Panama?

    Yes. Cheapflights offers flight deals from Spartanburg to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Spartanburg to Panama?

    Currently, August is the cheapest month in which you can book a flight from Spartanburg to Panama (average of $267). Flying from Spartanburg to Panama in January is currently the most expensive (average of $435). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Spartanburg to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Spartanburg to Panama

Discover the top 3 airlines that operate flights from Spartanburg to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$353Average$574FlexibilityNo cancel feeOn-time71%
DeltaCheapest$371Average$546FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$383Average$470FlexibilityNo cancel feeOn-time69%

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