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$198+ Cheap flights from Spartanburg, SC to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — PTY
Dec 2 — Dec 91
Tue 12/2
Tue 12/9
1 adult, Economy
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Cheap flight deals from Spartanburg to Panama

Keep the following information in mind while searching for Spartanburg to Panama flight deals. Data was last updated November 2, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$400
(American Airlines)

One-way from

$198
(Avianca Connect)

Popular in

December

Cheapest in

September

Average price

$567
Provider with most accurate pricing for Charlotte Douglas-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Charlotte Douglas-Panama City Tocumen Intl flights.
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From Spartanburg to Panama
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One-way flight from Spartanburg to Panama
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Highest demand for flights based on searches. 11% potential increase in price ($75 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Spartanburg to Panama

Cheapest flights from Spartanburg to Panama
Explore the most affordable flight options available from Spartanburg to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/710:42 pmCLT - PTY
1 stop9h 24mMultiple Airlines
Fri 11/1410:47 amPTY - CLT
1 stop11h 10mMultiple Airlines
Deal found 11/1$398
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/28:43 pmCLT - PTY
1 stop17h 04mAmerican Airlines
Tue 12/92:50 pmPTY - CLT
1 stop9h 09mAmerican Airlines
Deal found 11/2$400
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/710:42 pmCLT - PTY
1 stop9h 24mMultiple Airlines
Wed 11/129:33 pmPTY - CLT
1 stop10h 14mMultiple Airlines
Deal found 11/1$409
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/710:42 pmCLT - PTY
1 stop9h 24mMultiple Airlines
Sat 11/159:33 pmPTY - CLT
1 stop10h 14mMultiple Airlines
Deal found 11/1$416
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1010:42 pmCLT - PTY
1 stop9h 48mMultiple Airlines
Tue 11/188:10 amPTY - CLT
2 stops11h 48mMultiple Airlines
Deal found 11/2$422
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/710:42 pmCLT - PTY
1 stop9h 24mMultiple Airlines
Thu 11/136:11 pmPTY - CLT
1 stop13h 36mMultiple Airlines
Deal found 11/1$425
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/39:38 pmCLT - PTY
1 stop10h 28mMultiple Airlines
Wed 11/59:33 pmPTY - CLT
1 stop10h 14mMultiple Airlines
Deal found 10/31$430
This Avianca Connect deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/187:59 pmCLT - PTY
2 stops12h 51mMultiple Airlines
Sun 11/232:55 pmPTY - CLT
2 stops17h 54mMultiple Airlines
Deal found 11/1$436
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/3010:45 pmCLT - PTY
1 stop14h 58mAmerican Airlines
Sat 12/64:43 pmPTY - CLT
1 stop15h 24mAmerican Airlines
Deal found 11/1$440

Cheapflights Fare Finder

 
Customize your flight search to find flights from Spartanburg to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
Use the filters below to find and compare flights from Spartanburg to Panama that are best for you.

Fly from

Spartanburg

Fly to

Panama

Route

Depart

Return

Price

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 1/29

6:30 am-1:27 pm

1 stop6h 57m

Panama City Tocumen Intl

Mon 2/2

4:50 pm-7:31 am

2 stops14h 41m

$410

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 2/17

9:54 am-2:02 pm

1 stop28h 08m

Panama City Tocumen Intl

Thu 2/26

3:27 pm-8:42 am

1 stop17h 15m

$412

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 12/1

5:15 am-1:43 pm

1 stop8h 28m

Panama City Tocumen Intl

Thu 12/4

2:50 pm-7:51 am

1 stop17h 01m

$440

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sun 11/30

5:15 am-1:43 pm

1 stop8h 28m

Panama City Tocumen Intl

Sat 12/6

4:43 pm-6:38 am

2 stops13h 55m

$444

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 12/15

7:58 pm-3:42 pm

1 stop19h 44m

Panama City Tocumen Intl

Thu 12/18

4:55 pm-9:10 am

1 stop16h 15m

$449

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 3/4

6:33 am-2:45 pm

1 stop8h 12m

Panama City Tocumen Intl

Mon 3/9

7:55 am-9:44 pm

1 stop12h 49m

$468

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 3/12

11:08 am-7:02 pm

1 stop8h 54m

Panama City Tocumen Intl

Tue 3/17

9:30 am-9:42 pm

1 stop11h 12m

$468

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 3/12

5:30 am-12:55 pm

1 stop8h 25m

Panama City Tocumen Intl

Wed 3/18

2:20 pm-8:40 am

1 stop17h 20m

$468

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 2/17

6:33 am-7:38 pm

1 stop13h 05m

Panama City Tocumen Intl

Wed 2/25

11:35 am-9:57 pm

1 stop10h 22m

$468

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 3/10

6:45 am-6:38 pm

1 stop12h 53m

Panama City Tocumen Intl

Wed 3/18

9:30 am-9:42 pm

1 stop11h 12m

$468

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Showing 1-10 of 17 results
1
2

Best time to book a flight from Spartanburg to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Panama

What is the cheapest month to book a flight from Spartanburg to Panama?

Currently, November is the cheapest month in which you can book a flight from Spartanburg to Panama (average of $241). Flying from Spartanburg to Panama in January is currently the most expensive (average of $435). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to PA?

Find hourly flight availability from Spartanburg to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 2, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 32% on flights from Spartanburg to Panama by exploring options for tickets at noon.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated November 2, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Spartanburg to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,001 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Delta
7.9
Good
8,001 reviews
Delta
7.9
Good
8,001 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
United Airlines
7.4
Good
8,997 reviews
Delta
7.9
Good
8,001 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
American Airlines
7.2
Good
11,034 reviews
Delta
7.9
Good
8,001 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Spartanburg to Panama?

    Departing from Spartanburg to Panama will take you 6h 57m. Spartanburg and Panama are separated by a distance of 1808 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Spartanburg to Panama that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Panama.

  • Can I find deals for business class flights from Spartanburg to Panama?

    Yes. Cheapflights offers flight deals from Spartanburg to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Spartanburg to Panama?

    Currently, November is the cheapest month in which you can book a flight from Spartanburg to Panama (average of $241). Flying from Spartanburg to Panama in January is currently the most expensive (average of $435). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Spartanburg to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Spartanburg to Panama

Discover the top 3 airlines that operate flights from Spartanburg to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$371Average$552FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$383Average$479FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$383Average$573FlexibilityNo cancel feeOn-time71%

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