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Panama

$158+ Cheap flights from Spartanburg, SC to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — PTY
Oct 14 — Oct 211
Tue 10/14
Tue 10/21
1 adult, Economy
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Cheap flight deals from Spartanburg to Panama

Keep the following information in mind while searching for Spartanburg to Panama flight deals. Data was last updated September 14, 2025.

Round-trip from

$399
(United Airlines)

One-way from

$158
(Avianca Connect)

Popular in

December

Cheapest in

October

Average price

$512
From Spartanburg to Panama
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One-way flight from Spartanburg to Panama
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Highest demand for flights based on searches. 17% potential increase in price ($124 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($34 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Spartanburg to Panama

Cheapest flights from Spartanburg to Panama
Explore the most affordable flight options available from Spartanburg to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2025.

This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:45 amCLT - PTY
1 stop8h 00mUnited Airlines
Wed 11/58:55 amPTY - CLT
1 stop12h 41mUnited Airlines
Deal found 9/14$399
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/116:45 amCLT - PTY
1 stop12h 53mUnited Airlines
Tue 11/188:55 amPTY - CLT
1 stop12h 41mUnited Airlines
Deal found 9/14$403
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/147:00 amCLT - PTY
1 stop8h 14mUnited Airlines
Mon 10/203:30 pmPTY - CLT
1 stop29h 29mUnited Airlines
Deal found 9/12$404
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1110:01 pmCLT - PTY
2 stops15h 48mAmerican Airlines
Tue 11/182:49 pmPTY - CLT
2 stops15h 41mAmerican Airlines
Deal found 9/12$408
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/99:47 amCLT - PTY
1 stop28h 25mDelta
Thu 11/203:37 pmPTY - CLT
1 stop8h 14mDelta
Deal found 9/14$410
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:15 amCLT - PTY
1 stop7h 41mDelta
Tue 10/282:21 pmPTY - CLT
1 stop8h 29mDelta
Deal found 9/12$415
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/277:29 pmCLT - PTY
1 stop13h 42mMultiple Airlines
Mon 11/310:38 amPTY - CLT
1 stop11h 19mMultiple Airlines
Deal found 9/12$416
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:00 amCLT - PTY
2 stops9h 03mAmerican Airlines
Tue 10/283:15 pmPTY - CLT
2 stops15h 35mAmerican Airlines
Deal found 9/12$420
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/116:45 amCLT - PTY
1 stop12h 53mUnited Airlines
Sat 11/154:41 pmPTY - CLT
1 stop18h 10mUnited Airlines
Deal found 9/14$423
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/198:13 pmCLT - PTY
1 stop17h 43mDelta
Sat 10/252:21 pmPTY - CLT
1 stop19h 39mDelta
Deal found 9/13$428
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/82:27 pmCLT - PTY
1 stop23h 45mDelta
Wed 11/193:37 pmPTY - CLT
1 stop17h 04mDelta
Deal found 9/14$430
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/118:24 pmCLT - PTY
1 stop19h 13mAmerican Airlines
Mon 12/152:50 pmPTY - CLT
1 stop17h 01mAmerican Airlines
Deal found 9/12$432

Cheapflights Fare Finder

 
Customize your flight search to find flights from Spartanburg to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 14, 2025.
Use the filters below to find and compare flights from Spartanburg to Panama that are best for you.

Fly from

Spartanburg

Fly to

Panama

Route

Depart

Return

Price

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 11/10

7:55 am-2:12 pm

1 stop6h 17m

Panama City Tocumen Intl

Thu 11/20

3:37 pm-8:41 am

1 stop17h 04m

$403

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 10/25

6:15 am-12:56 pm

1 stop7h 41m

Panama City Tocumen Intl

Tue 10/28

2:21 pm-11:50 pm

1 stop8h 29m

$415

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 10/25

5:16 am-2:03 pm

1 stop9h 47m

Panama City Tocumen Intl

Tue 10/28

3:15 pm-7:50 am

2 stops15h 35m

$420

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 11/11

6:45 am-7:38 pm

1 stop12h 53m

Panama City Tocumen Intl

Sun 11/16

8:55 am-9:36 pm

1 stop12h 41m

$423

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 11/11

6:45 am-7:38 pm

1 stop12h 53m

Panama City Tocumen Intl

Fri 11/21

8:55 am-9:36 pm

1 stop12h 41m

$423

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 11/10

7:55 am-2:12 pm

1 stop6h 17m

Panama City Tocumen Intl

Fri 11/21

3:37 pm-1:27 pm

1 stop21h 50m

$430

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 11/8

2:27 pm-2:12 pm

1 stop23h 45m

Panama City Tocumen Intl

Wed 11/19

3:37 pm-8:41 am

1 stop17h 04m

$430

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 11/13

7:18 pm-2:12 pm

1 stop18h 54m

Panama City Tocumen Intl

Thu 11/20

3:37 pm-8:41 am

1 stop17h 04m

$430

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Fri 11/14

6:33 am-2:12 pm

1 stop7h 39m

Panama City Tocumen Intl

Sun 11/16

8:05 am-9:26 pm

1 stop13h 21m

$443

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 11/8

5:05 pm-2:12 pm

1 stop21h 07m

Panama City Tocumen Intl

Sun 11/16

8:05 am-8:14 pm

1 stop12h 09m

$450

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 16 results
1
2

Best time to book a flight from Spartanburg to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Panama

What is the cheapest month to book a flight from Spartanburg to Panama?

Currently, October is the cheapest month in which you can book a flight from Spartanburg to Panama (average of $478). Flying from Spartanburg to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to PA?

Find hourly flight availability from Spartanburg to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 14, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Spartanburg to Panama as you normally would.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated September 14, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Spartanburg to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,956 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,956 reviews
Delta
8.0
Very good
7,956 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,931 reviews
Delta
8.0
Very good
7,956 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,956 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Spartanburg to Panama?

    Departing from Spartanburg to Panama will take you 6h 17m. Spartanburg and Panama are separated by a distance of 1808 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Spartanburg to Panama that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Panama.

  • Can I find deals for business class flights from Spartanburg to Panama?

    Yes. Cheapflights offers flight deals from Spartanburg to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Spartanburg to Panama?

    Currently, October is the cheapest month in which you can book a flight from Spartanburg to Panama (average of $478). Flying from Spartanburg to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Spartanburg to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Augusta to San José flights
Columbia to San Salvador flights
Columbia to San Pedro Sula flights
Myrtle Beach to Guatemala City flights
Hilton Head Island to San José flights
Columbia to Philip S.W.Goldson flights
Columbia to Liberia flights
Augusta to Philip S.W.Goldson flights
Hilton Head Island to Liberia flights

Top 3 airlines flying from Spartanburg to Panama

Discover the top 3 airlines that operate flights from Spartanburg to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$352Average$464FlexibilityNo cancel feeOn-time69%
DeltaCheapest$371Average$584FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$376Average$575FlexibilityNo cancel feeOn-time71%

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