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Panama City

$389+ Cheap flights from St. Louis (STL) to Panama City (PTY)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/6. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Panama City Tocumen Intl are usually found in April or May, booked 41 days in advance, depart on a Tuesday or Wednesday and return on a Thursday

Find flight deals from St. Louis to Panama City

Cheapest flights from St. Louis to Panama City
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/76:00 amSTL - PTY
1 stop7h 21mDelta
Thu 12/113:46 pmPTY - STL
1 stop8h 56mDelta
Deal found 10/27$411
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/76:53 pmSTL - PTY
2 stops19h 49mAmerican Airlines
Thu 12/112:50 pmPTY - STL
2 stops18h 18mAmerican Airlines
Deal found 10/27$415
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/76:00 amSTL - PTY
1 stop7h 21mDelta
Sat 12/138:05 amPTY - STL
1 stop10h 55mDelta
Deal found 10/28$428
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/76:53 pmSTL - PTY
2 stops17h 54mAmerican Airlines
Sat 12/134:43 pmPTY - STL
2 stops16h 58mAmerican Airlines
Deal found 10/28$432
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:15 amSTL - PTY
1 stop12h 23mUnited Airlines
Fri 12/198:55 amPTY - STL
1 stop14h 06mUnited Airlines
Deal found 10/28$459
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/76:42 pmSTL - PTY
2 stops19h 03mUnited Airlines
Sat 12/138:55 amPTY - STL
1 stop14h 03mUnited Airlines
Deal found 10/28$460
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:58 pmSTL - PTY
2 stops20h 44mAmerican Airlines
Fri 12/192:53 pmPTY - STL
2 stops18h 42mAmerican Airlines
Deal found 10/28$465
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:15 amSTL - PTY
1 stop12h 23mUnited Airlines
Thu 12/188:55 amPTY - STL
1 stop14h 00mUnited Airlines
Deal found 10/27$467
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1711:20 amSTL - PTY
1 stop7h 18mUnited Airlines
Wed 12/38:55 amPTY - STL
1 stop14h 03mUnited Airlines
Deal found 10/27$482
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/166:43 pmSTL - PTY
2 stops19h 02mUnited Airlines
Wed 12/38:55 amPTY - STL
1 stop14h 03mUnited Airlines
Deal found 10/27$486
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/165:17 pmSTL - PTY
1 stop19h 55mDelta
Thu 12/43:46 pmPTY - STL
1 stop8h 56mDelta
Deal found 10/27$490
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/176:15 amSTL - PTY
1 stop12h 23mUnited Airlines
Sat 12/611:35 amPTY - STL
1 stop11h 23mUnited Airlines
Deal found 10/27$499

Cheap flight deals from St. Louis to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$389
(United Airlines)

Popular in

February

Cheapest in

April

Average price

$570
Provider with most accurate pricing for Lambert-St Louis-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City Tocumen Intl flights.
Search Deals
From Lambert-St Louis to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($47 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

St. Louis

Fly to

Panama City

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 4/6

8:30 am-7:31 pm

1 stop11h 01m

Panama City Tocumen Intl

Mon 4/13

7:55 am-10:06 pm

1 stop14h 11m

$389

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

6:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Wed 2/25

11:35 am-10:14 pm

1 stop11h 39m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 12/7

6:00 am-2:21 pm

1 stop7h 21m

Panama City Tocumen Intl

Thu 12/11

3:46 pm-11:42 pm

1 stop8h 56m

$411

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 1/28

6:00 am-2:45 pm

1 stop7h 45m

Panama City Tocumen Intl

Sun 3/29

9:45 am-9:55 pm

1 stop12h 10m

$411

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 1/9

3:30 pm-1:27 pm

2 stops20h 57m

Panama City Tocumen Intl

Fri 1/16

4:50 pm-9:08 am

1 stop17h 18m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 4/10

7:03 pm-12:15 pm

2 stops17h 12m

Panama City Tocumen Intl

Fri 4/17

1:55 pm-9:35 pm

1 stop7h 40m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 12/7

6:53 pm-3:42 pm

2 stops19h 49m

Panama City Tocumen Intl

Thu 12/11

2:50 pm-11:59 pm

1 stop10h 09m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 2/4

6:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Sun 2/8

10:00 am-10:58 pm

2 stops13h 58m

$415

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Compare providers for flights from St. Louis to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Panama City in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on St. Louis-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from St. Louis-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama City

How far ahead should I book a flight from St. Louis to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Panama City. Price data was last updated on October 24, 2025.

The best time to book flights from St. Louis to Panama City is 41 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from St. Louis to Panama City?

Currently, June is the cheapest month in which you can book a flight from St. Louis to Panama City (average of $208). Flying from St. Louis to Panama City in February is currently the most expensive (average of $546). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to PTY?

Find hourly flight availability from St. Louis to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

When flying from St. Louis to Panama City, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 25% versus a flight in the evening.

How much does it cost to fly round-trip from St. Louis to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated October 28, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from St. Louis to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Overall

7.9

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
9,001 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Panama City?

    There are many flights that can get you from St. Louis to Panama City in 11h 01m. Fly via United Airlines to get the fastest option. Airlines will cover a distance of 2159 mi.

  • What are the cheapest airlines flying from St. Louis to Panama City round-trip?

    Cheapflights users have booked flights from St. Louis to Panama City round-trip from $373. Other airlines that can offer you cheap pricing are United Airlines, from $401, and American Airlines, from $410. Delta is 32% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from St. Louis to Panama City that include hotel bookings?

    Yes. In addition to deals on St. Louis to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama City.

  • Can I find deals for business class flights from St. Louis to Panama City?

    Yes. Cheapflights offers flight deals from St. Louis to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Panama City?

    Currently, June is the cheapest month in which you can book a flight from St. Louis to Panama City (average of $208). Flying from St. Louis to Panama City in February is currently the most expensive (average of $546). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for St. Louis to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Kansas City to Panama City flights
Springfield to Panama City flights

Top 3 airlines flying from St. Louis to Panama City

Discover the top 3 airlines that operate flights from St. Louis to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$373Average$587FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$401Average$559FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$410Average$577FlexibilityNo cancel feeOn-time71%

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