How often are flights from St. Louis to Panama City delayed?

About 0% of weekly flights between St. Louis and Panama City have experienced delays in the past year, with the average delay time being 0 minutes.

What is the most punctual flight time for St. Louis to Panama City flights?

Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.

What day of the week experiences the fewest flight delays on this route?

Tuesday tends to have the lowest number of delays on this route, whereas Tuesday has historically faced a higher average of delays compared to other days of the week.

How long is the flight from St. Louis to Panama City?

There are many flights that can get you from St. Louis to Panama City in 6h 55m. Fly via United Airlines or Delta to get the fastest option. Airlines will cover a distance of 2159 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines flying from St. Louis to Panama City round-trip?

Cheapflights users have booked flights from St. Louis to Panama City round-trip from $227. Other airlines that can offer you cheap pricing are United Airlines, from $393, and American Airlines, from $394. Delta is 59% cheaper than the average price of flights available within the next 90 days to this destination.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the most popular airlines that fly from St. Louis to Panama City?

Before booking your flight from St. Louis to Panama City check out the most popular airlines for this route: United Airlines, American Airlines or Delta.

Most accurate provider : When it comes to deals on St. Louis-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on St. Louis-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from St. Louis-Panama City flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on St. Louis-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from St. Louis to Panama City that include hotel bookings?

Yes. In addition to deals on St. Louis to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from St. Louis to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama City.

Can I find deals for business class flights from St. Louis to Panama City?

Yes. Cheapflights offers flight deals from St. Louis to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$181+ Flights from St. Louis to Panama City

Q: How much does it cost to fly round-trip from St. Louis to Panama City?

Airfare is below average for this route at the moment. St. Louis to Panama City flights typically cost between $564 and $865 in February. The cheapest round-trip price found within the last 3 days was $394 on United Airlines (Feb 17-Feb 25).

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

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Cheapflights Tip: The best prices from Lambert-St Louis to Panama City Tocumen Intl are usually found in April or May, booked 41 days in advance, depart on a Tuesday or Wednesday and return on a Thursday

Cheap flight deals from St. Louis to Panama City

Cheapest flights from St. Louis to Panama City
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Wed 12/315:05 amSTL - PTY

1 stop9h 49mAmerican Airlines

Mon 1/54:55 pmPTY - STL

2 stops17h 45mAmerican Airlines

Deal found 12/11

$776

Wed 12/316:00 amSTL - PTY

1 stop9h 39mMultiple Airlines

Mon 1/511:33 amPTY - STL

2 stops24h 23mMultiple Airlines

Deal found 12/10

$1,245

Wed 12/318:15 amSTL - PTY

2 stops15h 25mAvianca

Mon 1/57:50 pmPTY - STL

2 stops15h 23mAvianca

Deal found 12/10

$5,366

Best flights from St. Louis to Panama City
Discover carefully curated flight deals from St. Louis to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 12, 2025.

Tue 3/176:00 amSTL - PTY

1 stop12h 38mUnited Airlines

Tue 3/243:41 pmPTY - STL

1 stop17h 40mUnited Airlines

Deal found 12/10

$394

Wed 4/296:00 amSTL - PTY

1 stop6h 55mDelta

Wed 5/62:20 pmPTY - STL

1 stop9h 18mDelta

Deal found 12/10

$394

Wed 4/295:35 amSTL - PTY

1 stop6h 40mAmerican Airlines

Wed 5/61:55 pmPTY - STL

2 stops22h 10mAmerican Airlines

Deal found 12/10

$398

Tue 2/1710:10 amSTL - PTY

1 stop8h 28mUnited Airlines

Wed 2/254:41 pmPTY - STL

1 stop17h 42mUnited Airlines

Deal found 12/10

$394

Tue 3/175:51 pmSTL - PTY

2 stops18h 49mAmerican Airlines

Tue 3/243:13 pmPTY - STL

2 stops19h 49mAmerican Airlines

Deal found 12/10

$398

Sun 2/154:49 pmSTL - PTY

2 stops20h 56mUnited Airlines

Wed 2/184:41 pmPTY - STL

1 stop17h 42mUnited Airlines

Deal found 12/9

$398

Tue 2/175:56 pmSTL - PTY

2 stops18h 54mAmerican Airlines

Wed 2/252:50 pmPTY - STL

2 stops22h 39mAmerican Airlines

Deal found 12/11

$398

Thu 1/228:05 amSTL - PTY

2 stops10h 33mUnited Airlines

Thu 1/298:55 amPTY - STL

1 stop7h 57mUnited Airlines

Deal found 12/12

$398

Last-minute flights from St. Louis to Panama City
Discover last-minute flight deals from St. Louis to Panama City. Data last updated December 12, 2025 and is based on user searches.

Fri 1/96:00 amSTL - PTY

1 stop10h 07mUnited Airlines

Tue 1/134:41 pmPTY - STL

1 stop17h 41mUnited Airlines

Deal found 12/10

$439

Sat 1/106:00 amSTL - PTY

1 stop7h 45mUnited Airlines

Wed 1/144:41 pmPTY - STL

1 stop17h 41mUnited Airlines

Deal found 12/10

$411

Sat 1/105:07 pmSTL - PTY

1 stop21h 31mAmerican Airlines

Fri 1/164:50 pmPTY - STL

2 stops19h 13mAmerican Airlines

Deal found 12/9

$426

Sat 1/106:00 amSTL - PTY

1 stop12h 38mUnited Airlines

Fri 1/164:41 pmPTY - STL

1 stop30h 19mUnited Airlines

Deal found 12/9

$436

Thu 1/226:00 amSTL - PTY

1 stop10h 07mUnited Airlines

Thu 1/298:55 amPTY - STL

1 stop7h 57mUnited Airlines

Deal found 12/12

$394

Thu 1/223:37 pmSTL - PTY

2 stops20h 50mAmerican Airlines

Sun 2/14:50 pmPTY - STL

2 stops23h 14mAmerican Airlines

Deal found 12/12

$420

Sat 1/246:00 amSTL - PTY

1 stop7h 45mUnited Airlines

Sat 1/314:41 pmPTY - STL

1 stop17h 41mUnited Airlines

Deal found 12/10

$428

Sun 1/254:35 pmSTL - PTY

1 stop26h 03mUnited Airlines

Sun 2/18:55 amPTY - STL

1 stop14h 05mUnited Airlines

Deal found 12/12

$419

Sun 1/255:59 pmSTL - PTY

2 stops20h 39mAmerican Airlines

Sun 2/14:50 pmPTY - STL

2 stops23h 14mAmerican Airlines

Deal found 12/12

$437

One-way flights from St. Louis to Panama City
Search for one-way flight options from St. Louis to Panama City. Find affordable one-way fares based on user searches. Data last updated December 12, 2025.

Fri 1/236:00 amSTL - PTY

1 stop12h 38mUnited Airlines

Deal found 12/12

$181

Fri 1/25:00 amSTL - PTY

2 stops9h 54mAmerican Airlines

Deal found 12/11

$252

Fri 1/25:02 pmSTL - PTY

2 stops20h 43mUnited Airlines

Deal found 12/11

$272

Fri 1/238:22 pmSTL - PTY

3 stops22h 58mMultiple Airlines

Deal found 12/12

$291

Fri 1/24:27 pmSTL - PTY

3 stops38h 12mMultiple Airlines

Deal found 12/11

$440

Find flight deals from St. Louis to Panama City

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$394 (United Airlines)
One-way from	$181 (United Airlines)
Popular in	December
Cheapest in	April
Average price	$719

Provider with most accurate pricing for Lambert-St Louis-Panama City Tocumen Intl flight deals.

Search Deals

Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City Tocumen Intl flights.

Search Deals

From Lambert-St Louis to Panama City Tocumen Intl

Search Deals

One-way flight from Lambert-St Louis to Panama City Tocumen Intl

Search Deals

Highest demand for flights based on searches. 6% potential increase in price ($40 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 3/17

6:00 am-6:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Tue 3/24

3:41 pm-9:21 am

1 stop17h 40m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

6:00 am-12:55 pm

1 stop6h 55m

Panama City Tocumen Intl

Wed 5/6

2:20 pm-11:38 pm

1 stop9h 18m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

10:10 am-7:38 pm

1 stop8h 28m

Panama City Tocumen Intl

Wed 2/25

4:41 pm-9:23 am

1 stop17h 42m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

5:35 am-12:15 pm

1 stop6h 40m

Panama City Tocumen Intl

Wed 5/6

1:55 pm-12:05 pm

2 stops22h 10m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 3/17

5:51 pm-12:40 pm

2 stops18h 49m

Panama City Tocumen Intl

Tue 3/24

3:13 pm-11:02 am

2 stops19h 49m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 2/15

4:49 pm-2:45 pm

2 stops20h 56m

Panama City Tocumen Intl

Wed 2/18

4:41 pm-9:23 am

1 stop17h 42m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

5:56 pm-1:50 pm

2 stops18h 54m

Panama City Tocumen Intl

Wed 2/25

2:50 pm-12:29 pm

2 stops22h 39m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 1/22

8:05 am-7:38 pm

2 stops10h 33m

Panama City Tocumen Intl

Thu 1/29

8:55 am-3:52 pm

1 stop7h 57m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 1/23

6:00 am-7:38 pm

1 stop12h 38m

$181

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 1/23

3:30 pm-1:27 pm

2 stops20h 57m

$181

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/12

Showing 1-10 of 14 results

Compare providers for flights from St. Louis to Panama City

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Panama City in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars
AranGrant	Price Accuracy2 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on St. Louis-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on St. Louis-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from St. Louis-Panama City flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on St. Louis-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama City

Prices

Delays

How far ahead should I book a flight from St. Louis to Panama City?

The best time to book flights from St. Louis to Panama City is 41 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from St. Louis to Panama City?

Currently, June is the cheapest month in which you can book a flight from St. Louis to Panama City (average of $201). Flying from St. Louis to Panama City in March is currently the most expensive (average of $484). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to PTY?

When flying from St. Louis to Panama City, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 25% versus a flight in the evening.

How much does it cost to fly round-trip from St. Louis to Panama City?

Reviews of airlines servicing Panama City

Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from St. Louis to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Delta

7.9

Good

8,008 reviews

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

United Airlines

7.4

Good

9,095 reviews

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

American Airlines

7.2

Good

11,050 reviews

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

Related info for your journey

How long is the flight from St. Louis to Panama City?
There are many flights that can get you from St. Louis to Panama City in 6h 55m. Fly via United Airlines or Delta to get the fastest option. Airlines will cover a distance of 2159 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from St. Louis to Panama City round-trip?
Cheapflights users have booked flights from St. Louis to Panama City round-trip from $227. Other airlines that can offer you cheap pricing are United Airlines, from $393, and American Airlines, from $394. Delta is 59% cheaper than the average price of flights available within the next 90 days to this destination.
Can I find deals for flights from St. Louis to Panama City that include hotel bookings?
Yes. In addition to deals on St. Louis to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from St. Louis to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama City.
Can I find deals for business class flights from St. Louis to Panama City?
Yes. Cheapflights offers flight deals from St. Louis to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from St. Louis to Panama City?
Currently, June is the cheapest month in which you can book a flight from St. Louis to Panama City (average of $201). Flying from St. Louis to Panama City in March is currently the most expensive (average of $484). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Complete your trip

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Other flights to Panama City

Top 3 airlines flying from St. Louis to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$373	Average$585	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$393	Average$553	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$394	Average$576	FlexibilityNo cancel fee	On-time71%

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$181+ Cheap flights from St. Louis (STL) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/23. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from St. Louis to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Lambert-St Louis to Panama City Tocumen Intl are usually found in April or May, booked 41 days in advance, depart on a Tuesday or Wednesday and return on a Thursday

Cheap flight deals from St. Louis to Panama City

Cheapest flights from St. Louis to Panama CityExplore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

Find flight deals from St. Louis to Panama City

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Compare providers for flights from St. Louis to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Panama City in December.

Best time to book a flight from St. Louis to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama City

How far ahead should I book a flight from St. Louis to Panama City?

What is the cheapest month to book a flight from St. Louis to Panama City?

What is the cheapest time of day to fly from STL to PTY?

How much does it cost to fly round-trip from St. Louis to Panama City?

How often are flights from St. Louis to Panama City delayed?

What is the most punctual flight time for St. Louis to Panama City flights?

What day of the week experiences the fewest flight delays on this route?

Reviews of airlines servicing Panama City

Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from St. Louis to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from St. Louis to Panama City?

What are the cheapest airlines flying from St. Louis to Panama City round-trip?

Can I find deals for flights from St. Louis to Panama City that include hotel bookings?

How can I find direct flights from St. Louis to Panama City?

Can I find deals for business class flights from St. Louis to Panama City?

What is the cheapest month to book a flight from St. Louis to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for St. Louis to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from St. Louis to Panama City

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Cheapest flights from St. Louis to Panama City
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.