How long is the flight from St. Louis to Panama City?

There are many flights that can get you from St. Louis to Panama City in 7h 02m. Fly via Delta, American Airlines, or United Airlines to get the fastest option. Airlines will cover a distance of 2159 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines flying from St. Louis to Panama City round-trip?

Cheapflights users have booked flights from St. Louis to Panama City round-trip from $373. Other airlines that can offer you cheap pricing are United Airlines, from $401, and American Airlines, from $410. Delta is 31% cheaper than the average price of flights available within the next 90 days to this destination.

What is the cheapest day to fly from St. Louis to Panama City?

Travelers seeking maximum savings on their St. Louis to Panama City flight should consider departing on Monday mornings when fares are most often at their lowest. Wednesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the most popular airlines that fly from St. Louis to Panama City?

Before booking your flight from St. Louis to Panama City check out the most popular airlines for this route: American Airlines, Delta or United Airlines.

What is the cheapest day to fly round-trip from St. Louis to Panama City?

It’s generally more expensive to depart on a Monday, if you have to leave on this day you can still search on Cheapflights to find great options that meet your needs.

How far in advance should I book a flight from St. Louis to Panama City?

Travelers have found it’s best to book a flight 42 days in advance to save up to 128% compared to booking the same week of travel. As your travel date approaches, the cost of this flight route may potentially increase. While opting to book 42 days out may not be an option for all, there are still additional ways to secure a deal in the near future. You might find a flight from St. Louis to Panama City 1-2 weeks in advance for as low as $527, or $527 for flights within the next 24 hours.

What is the cheapest month to fly from St. Louis to Panama City?

April is one of the best times of the year to fly to Panama City from St. Louis. Prices for April average $547 per person but you can even find prices for as low as $368. The most expensive prices can be found in the month of February. Opting for a April flight can save you 17% on your journey compared to booking in February

Can I find deals for flights from St. Louis to Panama City that include hotel bookings?

Yes. In addition to deals on St. Louis to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from St. Louis to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama City.

Can I find deals for business class flights from St. Louis to Panama City?

Yes. Cheapflights offers flight deals from St. Louis to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$393+ Cheap Flights from St. Louis to Panama City

Q: How much does it cost to fly round-trip from St. Louis to Panama City?

Airfare is below average for this route at the moment. St. Louis to Panama City flights typically cost between $529 and $585 in January. The cheapest round-trip price found within the last 3 days was $393 on Delta (Jan 28-Feb 4).

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Find cheap flights from St. Louis to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

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Cheapflights Tip: The best prices from Lambert-St Louis to Panama City Tocumen Intl are usually found in April or October, booked 41 days in advance, depart on a Tuesday or Wednesday and return on a Thursday

Cheap flight deals from St. Louis to Panama City

Round-trip from	$393 (Delta)
Popular in	February
Cheapest in	April
Average price	$549

From Lambert-St Louis to Panama City Tocumen Intl

Search Deals

Highest demand for flights based on searches. 10% potential increase in price ($62 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in September 2025

Search Deals

Find flight deals from St. Louis to Panama City

Cheapest flights from St. Louis to Panama City
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Tue 10/145:23 amSTL - PTY

1 stop8h 40mAmerican Airlines

Tue 10/283:15 pmPTY - STL

1 stop8h 41mAmerican Airlines

Deal found 9/8

$393

Tue 10/146:15 amSTL - PTY

1 stop12h 22mUnited Airlines

Tue 10/283:41 pmPTY - STL

2 stops20h 47mUnited Airlines

Deal found 9/8

$398

Thu 10/238:25 amSTL - PTY

1 stop10h 12mUnited Airlines

Mon 10/273:41 pmPTY - STL

1 stop27h 06mUnited Airlines

Deal found 9/8

$401

Fri 10/176:15 amSTL - PTY

1 stop12h 22mUnited Airlines

Mon 10/203:30 pmPTY - STL

1 stop18h 22mUnited Airlines

Deal found 9/9

$410

Sat 10/258:00 amSTL - PTY

2 stops10h 37mUnited Airlines

Sat 11/13:41 pmPTY - STL

2 stops20h 10mUnited Airlines

Deal found 9/10

$432

Thu 10/96:15 amSTL - PTY

1 stop12h 22mUnited Airlines

Thu 10/163:30 pmPTY - STL

2 stops22h 57mUnited Airlines

Deal found 9/11

$443

Sun 11/236:43 pmSTL - PTY

2 stops19h 02mUnited Airlines

Fri 11/284:41 pmPTY - STL

2 stops19h 10mUnited Airlines

Deal found 9/11

$463

Thu 10/96:08 pmSTL - PTY

1 stop19h 55mAmerican Airlines

Thu 10/163:15 pmPTY - STL

2 stops16h 54mAmerican Airlines

Deal found 9/10

$499

Best flights from St. Louis to Panama City
Discover carefully curated flight deals from St. Louis to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2025.

Tue 1/276:00 amSTL - PTY

1 stop7h 02mDelta

Tue 2/33:27 pmPTY - STL

1 stop9h 13mDelta

Deal found 9/10

$393

Tue 10/145:23 amSTL - PTY

1 stop8h 40mAmerican Airlines

Tue 10/283:15 pmPTY - STL

1 stop8h 41mAmerican Airlines

Deal found 9/8

$393

Thu 10/166:15 amSTL - PTY

1 stop12h 22mUnited Airlines

Mon 10/203:30 pmPTY - STL

1 stop18h 22mUnited Airlines

Deal found 9/9

$393

Wed 1/286:00 amSTL - PTY

1 stop7h 02mDelta

Tue 2/33:27 pmPTY - STL

1 stop9h 13mDelta

Deal found 9/10

$393

Tue 10/146:15 amSTL - PTY

1 stop12h 22mUnited Airlines

Tue 10/283:41 pmPTY - STL

2 stops20h 47mUnited Airlines

Deal found 9/8

$398

Wed 1/282:36 pmSTL - PTY

2 stops21h 34mAmerican Airlines

Wed 2/42:45 pmPTY - STL

2 stops18h 29mAmerican Airlines

Deal found 9/10

$398

Wed 1/286:00 amSTL - PTY

1 stop7h 02mDelta

Wed 2/43:27 pmPTY - STL

1 stop9h 13mDelta

Deal found 9/10

$393

Tue 1/276:30 amSTL - PTY

2 stops12h 08mUnited Airlines

Tue 2/38:55 amPTY - STL

2 stops15h 03mUnited Airlines

Deal found 9/10

$398

Wed 1/285:54 pmSTL - PTY

2 stops20h 41mAmerican Airlines

Tue 2/34:40 pmPTY - STL

2 stops19h 28mAmerican Airlines

Deal found 9/10

$398

Wed 1/2810:07 amSTL - PTY

1 stop8h 31mUnited Airlines

Wed 2/48:55 amPTY - STL

2 stops15h 03mUnited Airlines

Deal found 9/10

$398

Last-minute flights from St. Louis to Panama City
Discover last-minute flight deals from St. Louis to Panama City. Data last updated September 11, 2025 and is based on user searches.

Thu 10/96:15 amSTL - PTY

1 stop12h 22mUnited Airlines

Thu 10/163:30 pmPTY - STL

2 stops22h 57mUnited Airlines

Deal found 9/11

$443

Thu 10/96:08 pmSTL - PTY

1 stop19h 55mAmerican Airlines

Thu 10/163:15 pmPTY - STL

2 stops16h 54mAmerican Airlines

Deal found 9/10

$499

Tue 10/145:23 amSTL - PTY

1 stop8h 40mAmerican Airlines

Tue 10/283:15 pmPTY - STL

1 stop8h 41mAmerican Airlines

Deal found 9/8

$393

Tue 10/146:15 amSTL - PTY

1 stop12h 22mUnited Airlines

Tue 10/283:41 pmPTY - STL

2 stops20h 47mUnited Airlines

Deal found 9/8

$398

Fri 10/176:15 amSTL - PTY

1 stop12h 22mUnited Airlines

Mon 10/203:30 pmPTY - STL

1 stop18h 22mUnited Airlines

Deal found 9/9

$410

Thu 10/238:25 amSTL - PTY

1 stop10h 12mUnited Airlines

Mon 10/273:41 pmPTY - STL

1 stop27h 06mUnited Airlines

Deal found 9/8

$401

Thu 10/238:05 pmSTL - PTY

2 stops17h 58mAmerican Airlines

Mon 10/273:15 pmPTY - STL

2 stops20h 56mAmerican Airlines

Deal found 9/8

$463

Sat 10/258:25 amSTL - PTY

1 stop10h 12mUnited Airlines

Sat 11/13:41 pmPTY - STL

2 stops21h 47mUnited Airlines

Deal found 9/10

$432

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 1/27

6:00 am-2:02 pm

1 stop7h 02m

Panama City Tocumen Intl

Tue 2/3

3:27 pm-11:40 pm

1 stop9h 13m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 10/14

5:23 am-2:03 pm

1 stop8h 40m

Panama City Tocumen Intl

Tue 10/28

3:15 pm-11:56 pm

1 stop8h 41m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 10/16

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 10/20

3:30 pm-9:52 am

1 stop18h 22m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 1/28

6:00 am-2:02 pm

1 stop7h 02m

Panama City Tocumen Intl

Tue 2/3

3:27 pm-11:40 pm

1 stop9h 13m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 1/28

6:00 am-2:02 pm

1 stop7h 02m

Panama City Tocumen Intl

Wed 2/4

3:27 pm-11:40 pm

1 stop9h 13m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 10/14

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Tue 10/28

3:41 pm-12:28 pm

2 stops20h 47m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 1/28

2:36 pm-1:10 pm

2 stops21h 34m

Panama City Tocumen Intl

Wed 2/4

2:45 pm-8:14 am

2 stops18h 29m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 1/27

6:30 am-7:38 pm

2 stops12h 08m

Panama City Tocumen Intl

Tue 2/3

8:55 am-10:58 pm

2 stops15h 03m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 1/28

5:54 pm-3:35 pm

2 stops20h 41m

Panama City Tocumen Intl

Tue 2/3

4:40 pm-11:08 am

2 stops19h 28m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 1/28

10:07 am-7:38 pm

1 stop8h 31m

Panama City Tocumen Intl

Wed 2/4

8:55 am-10:58 pm

2 stops15h 03m

$398

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Best time to book a flight from St. Louis to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama City

How far ahead should I book a flight from St. Louis to Panama City?

The best time to book flights from St. Louis to Panama City is 41 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from St. Louis to Panama City?

Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama City (average of $478). Flying from St. Louis to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to PTY?

When flying from St. Louis to Panama City, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 26% versus a flight in the afternoon.

How much does it cost to fly round-trip from St. Louis to Panama City?

Reviews of airlines servicing Panama City

Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from St. Louis to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,960 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,937 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

How long is the flight from St. Louis to Panama City?
There are many flights that can get you from St. Louis to Panama City in 7h 02m. Fly via Delta, American Airlines, or United Airlines to get the fastest option. Airlines will cover a distance of 2159 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from St. Louis to Panama City round-trip?
Cheapflights users have booked flights from St. Louis to Panama City round-trip from $373. Other airlines that can offer you cheap pricing are United Airlines, from $401, and American Airlines, from $410. Delta is 31% cheaper than the average price of flights available within the next 90 days to this destination.
Can I find deals for flights from St. Louis to Panama City that include hotel bookings?
Yes. In addition to deals on St. Louis to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from St. Louis to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama City.
Can I find deals for business class flights from St. Louis to Panama City?
Yes. Cheapflights offers flight deals from St. Louis to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from St. Louis to Panama City?
Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama City (average of $478). Flying from St. Louis to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for St. Louis to Panama City

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Springfield to Panama City flights

Complete your trip

Panama City car rentals

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Juan Diaz car rentals

Pueblo Nuevo car rentals

Other flights to Panama City

Top 3 airlines flying from St. Louis to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$373	Average$569	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$401	Average$562	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$410	Average$576	FlexibilityNo cancel fee	On-time71%

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$393+ Cheap flights from St. Louis (STL) to Panama City (PTY)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from St. Louis to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Lambert-St Louis to Panama City Tocumen Intl are usually found in April or October, booked 41 days in advance, depart on a Tuesday or Wednesday and return on a Thursday

Cheap flight deals from St. Louis to Panama City

Round-trip from

Popular in

Cheapest in

Average price

Find flight deals from St. Louis to Panama City

Cheapest flights from St. Louis to Panama CityExplore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Best time to book a flight from St. Louis to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama City

How far ahead should I book a flight from St. Louis to Panama City?

What is the cheapest month to book a flight from St. Louis to Panama City?

What is the cheapest time of day to fly from STL to PTY?

How much does it cost to fly round-trip from St. Louis to Panama City?

Reviews of airlines servicing Panama City

Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from St. Louis to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from St. Louis to Panama City?

What are the cheapest airlines flying from St. Louis to Panama City round-trip?

Can I find deals for flights from St. Louis to Panama City that include hotel bookings?

How can I find direct flights from St. Louis to Panama City?

Can I find deals for business class flights from St. Louis to Panama City?

What is the cheapest month to book a flight from St. Louis to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for St. Louis to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from St. Louis to Panama City

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Travel Smart

Cheapest flights from St. Louis to Panama City
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.