What are the cheapest airlines flying from St. Louis to Panama City round-trip?

Cheapflights users have booked flights from St. Louis to Panama City round-trip from $393. Other airlines that can offer you cheap pricing are Delta, from $401, and American Airlines, from $476. United Airlines is 26% cheaper than the average price of flights available within the next 90 days to this destination.

What is the cheapest day to fly from St. Louis to Panama City?

Travelers seeking maximum savings on their St. Louis to Panama City flight should consider departing on Monday mornings when fares are most often at their lowest. Wednesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from St. Louis to Panama City?

Before booking your flight from St. Louis to Panama City check out the most popular airlines for this route: American Airlines, Delta or United Airlines.

What is the cheapest day to fly round-trip from St. Louis to Panama City?

It’s generally more expensive to depart on a Monday, if you have to leave on this day you can still search on Cheapflights to find great options that meet your needs.

How far in advance should I book a flight from St. Louis to Panama City?

Travelers have found it’s best to book a flight 42 days in advance to save up to 128% compared to booking the same week of travel. As your travel date approaches, the cost of this flight route may potentially increase. While opting to book 42 days out may not be an option for all, there are still additional ways to secure a deal in the near future. You might find a flight from St. Louis to Panama City 1-2 weeks in advance for as low as $527, or $527 for flights within the next 24 hours.

What is the cheapest month to fly from St. Louis to Panama City?

April is one of the best times of the year to fly to Panama City from St. Louis. Prices for April average $535 per person but you can even find prices for as low as $368. The most expensive prices can be found in the month of March. Opting for a April flight can save you 20% on your journey compared to booking in March

Can I find deals for flights from St. Louis to Panama City that include hotel bookings?

Yes. In addition to deals on St. Louis to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from St. Louis to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama City.

Can I find deals for business class flights from St. Louis to Panama City?

Yes. Cheapflights offers flight deals from St. Louis to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$164+ Flights from St. Louis to Panama City

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Cheapflights Tip: The best prices from Lambert-St Louis to Panama City Tocumen Intl are usually found in April or October, booked 43 days in advance, depart on a Tuesday or Wednesday and return on a Thursday

Cheap flight deals from St. Louis to Panama City

Round-trip from	$393 (United Airlines)
One-way from	$164 (Delta)
Popular in	March
Cheapest in	April
Average price	$505

From Lambert-St Louis to Panama City Tocumen Intl

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One-way flight from Lambert-St Louis to Panama City Tocumen Intl

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Highest demand for flights based on searches. 3% potential increase in price ($22 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Find flight deals from St. Louis to Panama City

Cheapest flights from St. Louis to Panama City
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Mon 8/258:20 amSTL - PTY

1 stop10h 17mUnited Airlines

Tue 9/23:30 pmPTY - STL

1 stop18h 31mUnited Airlines

Deal found 6/10

$393

Mon 7/281:29 pmSTL - PTY

1 stop23h 44mDelta

Wed 8/62:28 pmPTY - STL

1 stop17h 54mDelta

Deal found 6/11

$401

Thu 7/318:01 pmSTL - PTY

2 stops18h 14mAmerican Airlines

Fri 8/83:30 pmPTY - STL

2 stops40h 36mAmerican Airlines

Deal found 6/11

$476

Wed 7/3011:24 amSTL - PTY

3 stops36h 46mMultiple Airlines

Wed 8/611:05 amPTY - STL

3 stops29h 26mMultiple Airlines

Deal found 6/11

$615

Best flights from St. Louis to Panama City
Discover carefully curated flight deals from St. Louis to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2025.

Mon 8/256:15 amSTL - PTY

1 stop12h 22mUnited Airlines

Mon 9/83:30 pmPTY - STL

1 stop18h 31mUnited Airlines

Deal found 6/10

$393

Mon 7/281:29 pmSTL - PTY

1 stop23h 44mDelta

Wed 8/62:28 pmPTY - STL

1 stop17h 54mDelta

Deal found 6/11

$401

Thu 7/318:01 pmSTL - PTY

2 stops18h 14mAmerican Airlines

Fri 8/83:30 pmPTY - STL

2 stops40h 36mAmerican Airlines

Deal found 6/11

$476

Wed 7/3011:24 amSTL - PTY

3 stops36h 46mMultiple Airlines

Wed 8/611:05 amPTY - STL

3 stops29h 26mMultiple Airlines

Deal found 6/11

$615

Fri 7/118:15 amSTL - PTY

1 stop12h 19mCopa Airlines

Fri 7/187:30 pmPTY - STL

1 stop14h 29mCopa Airlines

Deal found 6/11

$1,554

Last-minute flights from St. Louis to Panama City
Discover last-minute flight deals from St. Louis to Panama City. Data last updated June 12, 2025 and is based on user searches.

Wed 6/188:25 amSTL - PTY

1 stop7h 47mUnited Airlines

Wed 6/253:30 pmPTY - STL

1 stop18h 01mUnited Airlines

Deal found 6/11

$590

Sat 7/59:09 amSTL - PTY

2 stops15h 01mAvianca

Tue 7/83:20 amPTY - STL

2 stops15h 40mAvianca

Deal found 6/10

$2,546

Fri 7/118:15 amSTL - PTY

1 stop12h 19mCopa Airlines

Fri 7/187:30 pmPTY - STL

1 stop14h 29mCopa Airlines

Deal found 6/11

$1,554

Mon 7/214:28 pmSTL - PTY

2 stops20h 26mAmerican Airlines

Fri 7/251:55 pmPTY - STL

2 stops18h 18mAmerican Airlines

Deal found 6/9

$398

Tue 7/296:00 amSTL - PTY

1 stop7h 13mDelta

Thu 8/72:28 pmPTY - STL

1 stop17h 58mDelta

Deal found 6/11

$393

Tue 7/295:00 amSTL - PTY

2 stops13h 37mUnited Airlines

Tue 8/53:30 pmPTY - STL

1 stop27h 23mUnited Airlines

Deal found 6/11

$406

Wed 7/3011:24 amSTL - PTY

3 stops36h 46mMultiple Airlines

Wed 8/611:05 amPTY - STL

3 stops29h 26mMultiple Airlines

Deal found 6/11

$615

One-way flights from St. Louis to Panama City
Search for one-way flight options from St. Louis to Panama City. Find affordable one-way fares based on user searches. Data last updated June 12, 2025.

Mon 8/256:00 amSTL - PTY

1 stop6h 50mDelta

Deal found 6/10

$164

Mon 6/238:25 amSTL - PTY

1 stop10h 12mUnited Airlines

Deal found 6/11

$273

Mon 6/2311:28 amSTL - PTY

3 stops36h 42mMultiple Airlines

Deal found 6/11

$329

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 8/25

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 9/8

3:30 pm-10:01 am

1 stop18h 31m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 7/28

1:29 pm-1:13 pm

1 stop23h 44m

Panama City Tocumen Intl

Wed 8/6

2:28 pm-8:22 am

1 stop17h 54m

$401

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 7/31

8:01 pm-2:15 pm

2 stops18h 14m

Panama City Tocumen Intl

Fri 8/8

3:30 pm-8:06 am

2 stops40h 36m

$476

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 7/30

11:24 am-12:10 am

3 stops36h 46m

Panama City Tocumen Intl

Wed 8/6

11:05 am-4:31 pm

3 stops29h 26m

$615

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 7/11

8:15 am-8:34 pm

1 stop12h 19m

Panama City Tocumen Intl

Fri 7/18

7:30 pm-9:59 am

1 stop14h 29m

$1,554

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 8/25

6:00 am-12:50 pm

1 stop6h 50m

$164

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 6/23

8:25 am-6:37 pm

1 stop10h 12m

$273

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 6/23

11:28 am-12:10 am

3 stops36h 42m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from St. Louis to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama City

How far ahead should I book a flight from St. Louis to Panama City?

The best time to book flights from St. Louis to Panama City is 41 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from St. Louis to Panama City?

Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama City (average of $478). Flying from St. Louis to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to PTY?

When flying from St. Louis to Panama City, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 26% versus a flight in the afternoon.

Rainfall in Panama City by month

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,950 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Copa Airlines

7.5

Good

1,451 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,790 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from St. Louis to Panama City round-trip?
Cheapflights users have booked flights from St. Louis to Panama City round-trip from $393. Other airlines that can offer you cheap pricing are Delta, from $401, and American Airlines, from $476. United Airlines is 26% cheaper than the average price of flights available within the next 90 days to this destination.
Can I find deals for flights from St. Louis to Panama City that include hotel bookings?
Yes. In addition to deals on St. Louis to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from St. Louis to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama City.
Can I find deals for business class flights from St. Louis to Panama City?
Yes. Cheapflights offers flight deals from St. Louis to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from St. Louis to Panama City?
Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama City (average of $478). Flying from St. Louis to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

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Other flights to Panama City

Top 3 airlines flying from St. Louis to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$373	Average$532	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$394	Average$542	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$445	Average$533	FlexibilityNo cancel fee	On-time69%

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$164+ Cheap flights from St. Louis (STL) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from St. Louis to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Lambert-St Louis to Panama City Tocumen Intl are usually found in April or October, booked 43 days in advance, depart on a Tuesday or Wednesday and return on a Thursday

Cheap flight deals from St. Louis to Panama City

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from St. Louis to Panama City

Cheapest flights from St. Louis to Panama CityExplore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Best time to book a flight from St. Louis to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama City

How far ahead should I book a flight from St. Louis to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Panama City. Price data was last updated on June 9, 2025.

What is the cheapest month to book a flight from St. Louis to Panama City?

What is the cheapest time of day to fly from STL to PTY?

Find hourly flight availability from St. Louis to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

Reviews of airlines servicing Panama City

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from St. Louis to Panama City round-trip?

Can I find deals for flights from St. Louis to Panama City that include hotel bookings?

How can I find direct flights from St. Louis to Panama City?

Can I find deals for business class flights from St. Louis to Panama City?

What is the cheapest month to book a flight from St. Louis to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for St. Louis to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from St. Louis to Panama City

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Cheapest flights from St. Louis to Panama City
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.