HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$164+ Cheap flights from St. Louis (STL) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/18. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Aug 4 — Aug 111
Mon 8/4
Mon 8/11
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from St. Louis to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Lambert-St Louis to Panama City Tocumen Intl are usually found in April or October, booked 41 days in advance, depart on a Tuesday or Wednesday and return on a Thursday

Cheap flight deals from St. Louis to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 30, 2025.

Round-trip from

$393
(American Airlines)

One-way from

$164
(United Airlines)

Popular in

March

Cheapest in

April

Average price

$590
From Lambert-St Louis to Panama City Tocumen Intl
Search Deals
One-way flight from Lambert-St Louis to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($14 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from St. Louis to Panama City

Cheapest flights from St. Louis to Panama City
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/116:01 amSTL - PTY
1 stop6h 54mDelta
Thu 9/182:10 pmPTY - STL
1 stop9h 14mDelta
Deal found 7/27$393
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/116:00 pmSTL - PTY
2 stops20h 31mAmerican Airlines
Thu 9/183:31 pmPTY - STL
2 stops17h 43mAmerican Airlines
Deal found 7/27$398
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/116:15 amSTL - PTY
1 stop12h 22mUnited Airlines
Thu 9/183:30 pmPTY - STL
1 stop27h 20mUnited Airlines
Deal found 7/28$401
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/55:26 pmSTL - PTY
3 stops31h 19mMultiple Airlines
Sat 8/93:20 amPTY - STL
3 stops30h 32mMultiple Airlines
Deal found 7/28$834

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

St. Louis

Fly to

Panama City

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 9/11

6:01 am-12:55 pm

1 stop6h 54m

Panama City Tocumen Intl

Thu 9/18

2:10 pm-11:24 pm

1 stop9h 14m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 9/11

6:00 pm-2:31 pm

2 stops20h 31m

Panama City Tocumen Intl

Thu 9/18

3:31 pm-11:59 pm

1 stop8h 28m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 9/11

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Thu 9/18

3:30 pm-6:50 pm

1 stop27h 20m

$401

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 10/22

1:00 pm-12:10 am

3 stops35h 10m

Panama City Tocumen Intl

Sat 10/25

2:55 am-12:00 pm

3 stops33h 05m

$906

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 9/18

6:15 am-6:37 pm

1 stop12h 22m

$164

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 9/19

6:00 pm-2:31 pm

2 stops20h 31m

$187

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 9/19

1:57 pm-4:52 pm

3 stops26h 55m

$339

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Best time to book a flight from St. Louis to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama City

How far ahead should I book a flight from St. Louis to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Panama City. Price data was last updated on July 25, 2025.

The best time to book flights from St. Louis to Panama City is 41 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from St. Louis to Panama City?

Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama City (average of $478). Flying from St. Louis to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to PTY?

Find hourly flight availability from St. Louis to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 30, 2025.

When flying from St. Louis to Panama City, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 26% versus a flight in the afternoon.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated July 30, 2025.
Read reviews from past customers who have flown United Airlines and American Airlines from St. Louis to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,896 reviews

Boarding

7.7

Crew

8.1

Food

6.6

Overall

7.4

Comfort

7.3

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
United Airlines
7.4
Good
8,896 reviews
United Airlines
7.4
Good
8,896 reviews

Boarding

7.7

Crew

8.1

Food

6.6

Overall

7.4

Comfort

7.3

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,896 reviews

Boarding

7.7

Crew

8.1

Food

6.6

Overall

7.4

Comfort

7.3

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from St. Louis to Panama City round-trip?

    Cheapflights users have booked flights from St. Louis to Panama City round-trip from $393. Another airline that can offer you cheap pricing is United Airlines. American Airlines is 27% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from St. Louis to Panama City that include hotel bookings?

    Yes. In addition to deals on St. Louis to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama City.

  • Can I find deals for business class flights from St. Louis to Panama City?

    Yes. Cheapflights offers flight deals from St. Louis to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Panama City?

    Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama City (average of $478). Flying from St. Louis to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for St. Louis to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Kansas City to Panama City flights
Springfield to Panama City flights

Top 3 airlines flying from St. Louis to Panama City

Discover the top 3 airlines that operate flights from St. Louis to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$373Average$564FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$410Average$565FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$435Average$566FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.