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Panama City

$200+ Cheap flights from St. Louis (STL) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Apr 11 — Apr 181
Sat 4/11
Sat 4/18
1 adult, Economy
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Cheap flight deals from St. Louis to Panama City

Cheapest flights from St. Louis to Panama City
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.

This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1510:09 am
STL
-
PTY
1 stop8h 28m
United Airlines
Tue 4/213:30 pm
PTY
-
STL
1 stop17h 55m
United Airlines
Deal found 3/9$465
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:09 am
STL
-
PTY
1 stop8h 28m
United Airlines
Thu 4/163:30 pm
PTY
-
STL
2 stops20h 52m
United Airlines
Deal found 3/8$469
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2110:09 am
STL
-
PTY
1 stop8h 28m
United Airlines
Sat 4/253:30 pm
PTY
-
STL
2 stops19h 15m
United Airlines
Deal found 3/8$473
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/22:57 pm
STL
-
PTY
1 stop23h 17m
United Airlines
Mon 8/1010:55 pm
PTY
-
STL
2 stops13h 18m
United Airlines
Deal found 3/8$478
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:00 am
STL
-
PTY
1 stop10h 12m
United Airlines
Sun 5/1710:00 am
PTY
-
STL
1 stop12h 30m
United Airlines
Deal found 3/9$482
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:00 am
STL
-
PTY
1 stop10h 12m
United Airlines
Mon 5/1810:00 am
PTY
-
STL
1 stop12h 30m
United Airlines
Deal found 3/11$485
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/97:45 am
STL
-
PTY
2 stops20h 19m
United Airlines
Sun 4/123:30 pm
PTY
-
STL
2 stops16h 55m
United Airlines
Deal found 3/9$486
This BusinessClass deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:10 am
STL
-
PTY
1 stop7h 27m
Copa Airlines
Tue 7/143:30 pm
PTY
-
STL
1 stop18h 37m
Copa Airlines
Deal found 3/12$487
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:00 am
STL
-
PTY
2 stops12h 37m
United Airlines
Thu 7/163:30 pm
PTY
-
STL
2 stops17h 11m
United Airlines
Deal found 3/12$489
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/195:24 am
STL
-
PTY
1 stop7h 22m
American Airlines
Wed 4/221:49 pm
PTY
-
STL
1 stop8h 35m
American Airlines
Deal found 3/12$491
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:30 pm
STL
-
PTY
1 stop19h 44m
United Airlines
Tue 8/117:55 am
PTY
-
STL
1 stop9h 54m
United Airlines
Deal found 3/12$494

Find flight deals from St. Louis to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$465
(United Airlines)

One-way from

$200
(United Airlines)

Popular in

December

Cheapest in

April

Average price

$580
Provider with most accurate pricing for Lambert-St Louis-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City Tocumen Intl flights.
Search Deals
From Lambert-St Louis to Panama City Tocumen Intl
Search Deals
One-way flight from Lambert-St Louis to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($39 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 4/14

6:00 am-4:12 pm

1 stop10h 12m

Panama City Tocumen Intl

Thu 4/16

3:30 pm-8:25 am

2 stops16h 55m

$469

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 8/5

1:13 pm-4:04 am

2 stops14h 51m

Panama City Tocumen Intl

Tue 8/11

10:00 am-11:00 pm

2 stops13h 00m

$469

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/15

6:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Tue 4/21

3:30 pm-8:25 am

2 stops16h 55m

$469
Quickest round-trip

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 5/14

6:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Sun 5/17

10:00 am-10:30 pm

1 stop12h 30m

$482

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 4/7

6:00 am-4:12 pm

1 stop10h 12m

Panama City Tocumen Intl

Tue 4/14

3:30 pm-9:25 am

1 stop17h 55m

$485

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 5/25

8:15 pm-4:12 pm

2 stops19h 57m

Panama City Tocumen Intl

Sat 5/30

3:30 pm-10:07 am

1 stop18h 37m

$486

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 4/9

6:00 am-4:12 pm

1 stop10h 12m

Panama City Tocumen Intl

Sun 4/12

3:30 pm-8:25 am

2 stops16h 55m

$486

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 4/17

6:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Sun 4/19

3:30 pm-8:25 am

2 stops16h 55m

$503
Cheapest one-way

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 4/9

6:00 am-6:37 pm

1 stop12h 37m

$200

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 8/11

5:46 pm-2:20 pm

2 stops20h 34m

$210

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/9

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

Compare providers for flights from St. Louis to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Panama City in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*2 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama City

What is the cheapest month to book a flight from St. Louis to Panama City?

Currently, June is the cheapest month in which you can book a flight from St. Louis to Panama City (average of $194). Flying from St. Louis to Panama City in May is currently the most expensive (average of $449). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated March 12, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from St. Louis to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,286 reviews

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Overall

7.9

Food

7.2

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,286 reviews
Delta
7.9
Good
8,286 reviews

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Overall

7.9

Food

7.2

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,418 reviews
Delta
7.9
Good
8,286 reviews

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Overall

7.9

Food

7.2

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,435 reviews
Delta
7.9
Good
8,286 reviews

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Overall

7.9

Food

7.2

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Panama City?

    There are many flights that can get you from St. Louis to Panama City in 8h 28m. Fly via United Airlines to get the fastest option. Airlines will cover a distance of 2159 mi.

  • What are the cheapest airlines flying from St. Louis to Panama City round-trip?

    Cheapflights users have booked flights from St. Louis to Panama City round-trip from $227. Other airlines that can offer you cheap pricing are United Airlines, from $393, and American Airlines, from $393. Delta is 60% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from St. Louis to Panama City that include hotel bookings?

    Yes. In addition to deals on St. Louis to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama City.

  • Can I find deals for business class flights from St. Louis to Panama City?

    Yes. Cheapflights offers flight deals from St. Louis to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Panama City?

    Currently, June is the cheapest month in which you can book a flight from St. Louis to Panama City (average of $194). Flying from St. Louis to Panama City in May is currently the most expensive (average of $449). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for St. Louis to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Kansas City to Panama City flights
Springfield to Panama City flights

Top 3 airlines flying from St. Louis to Panama City

Discover the top 3 airlines that operate flights from St. Louis to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$227Average$590FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$393Average$530FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$393Average$588FlexibilityNo cancel feeOn-time71%

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