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$605+ Cheap flights from St. Louis (STL) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Aug 27 — Sep 31
Thu 8/27
Thu 9/3
1 adult, Economy
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Cheap flight deals from St. Louis to Panama

Cheapest flights from St. Louis to Panama
Explore the most affordable flight options available from St. Louis to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2026.

This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:30 am
STL
-
PTY
1 stop10h 01m
United Airlines
Mon 10/53:30 pm
PTY
-
STL
2 stops20h 43m
United Airlines
Deal found 7/26$605
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/812:59 pm
STL
-
PTY
2 stops25h 15m
United Airlines
Tue 9/153:30 pm
PTY
-
STL
2 stops24h 08m
United Airlines
Deal found 7/25$609
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/48:13 pm
STL
-
PTY
2 stops17h 00m
American Airlines
Wed 11/113:13 pm
PTY
-
STL
2 stops19h 56m
American Airlines
Deal found 7/24$614
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/77:00 am
STL
-
PTY
1 stop12h 31m
United Airlines
Mon 9/149:45 am
PTY
-
STL
1 stop13h 53m
United Airlines
Deal found 7/24$615
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:00 am
STL
-
PTY
1 stop12h 31m
United Airlines
Wed 9/233:30 pm
PTY
-
STL
2 stops20h 43m
United Airlines
Deal found 7/23$622
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/67:04 pm
STL
-
PTY
2 stops21h 08m
United Airlines
Sun 12/134:41 pm
PTY
-
STL
2 stops20h 25m
United Airlines
Deal found 7/27$626
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:20 pm
STL
-
PTY
2 stops21h 32m
American Airlines
Fri 10/301:52 pm
PTY
-
STL
2 stops22h 10m
American Airlines
Deal found 7/26$631
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2812:46 pm
STL
-
PTY
2 stops23h 40m
American Airlines
Sun 10/41:16 pm
PTY
-
STL
2 stops19h 21m
American Airlines
Deal found 7/26$636
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:15 am
STL
-
PTY
1 stop7h 59m
United Airlines
Fri 10/307:55 am
PTY
-
STL
1 stop8h 55m
United Airlines
Deal found 7/27$639
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:15 am
STL
-
PTY
1 stop12h 23m
United Airlines
Sat 11/148:55 am
PTY
-
STL
2 stops13h 45m
United Airlines
Deal found 7/27$643
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:15 am
STL
-
PTY
1 stop12h 23m
United Airlines
Mon 1/114:41 pm
PTY
-
STL
2 stops19h 00m
United Airlines
Deal found 7/24$677

Find flight deals from St. Louis to Panama

Keep the following information in mind while searching for St. Louis to Panama flight deals. Data was last updated July 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$605
(United Airlines)

Popular in

June

Cheapest in

April

Average price

$755
Provider with most accurate pricing for Lambert-St Louis-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City Tocumen Intl flights.
Search Deals
From Lambert-St Louis to Panama
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($109 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
Use the filters below to find and compare flights from St. Louis to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 9/9

7:00 am-7:31 pm

1 stop12h 31m

Panama City Tocumen Intl

Wed 9/16

9:45 am-11:38 pm

1 stop13h 53m

$605

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 9/8

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Tue 9/15

9:45 am-11:38 pm

1 stop13h 53m

$605

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 11/4

7:30 am-8:02 pm

2 stops11h 32m

Panama City Tocumen Intl

Mon 11/9

4:41 pm-12:10 pm

2 stops20h 29m

$609
Quickest round-trip

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 9/19

5:00 am-12:16 pm

1 stop7h 16m

Panama City Tocumen Intl

Tue 9/22

1:16 pm-9:49 pm

1 stop8h 33m

$622

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 9/19

7:00 am-7:31 pm

1 stop12h 31m

Panama City Tocumen Intl

Wed 9/23

3:30 pm-12:13 pm

2 stops20h 43m

$622

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 12/6

6:15 am-5:12 pm

1 stop9h 57m

Panama City Tocumen Intl

Sun 12/13

8:55 am-4:44 pm

1 stop8h 49m

$639

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 11/6

6:15 am-7:38 pm

1 stop12h 23m

Panama City Tocumen Intl

Sat 11/14

4:41 pm-10:02 am

1 stop18h 21m

$639

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 1/9

11:00 am-7:38 pm

1 stop7h 38m

Panama City Tocumen Intl

Sun 1/17

8:55 am-10:06 pm

1 stop14h 11m

$639

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 1/8

7:33 am-7:38 pm

2 stops11h 05m

Panama City Tocumen Intl

Sun 1/17

8:55 am-10:06 pm

1 stop14h 11m

$643

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/26

Sorted by cheapest first

Best time to book a flight from St. Louis to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama

What is the cheapest month to book a flight from St. Louis to Panama?

Currently, April is the cheapest month in which you can book a flight from St. Louis to Panama (average of $495). Flying from St. Louis to Panama in June is currently the most expensive (average of $900). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How often are flights from St. Louis to Panama delayed?

About 0% of weekly flights between St. Louis and Panama have experienced delays in the past year, with the average delay time being 0 minutes.

What is the most punctual flight time for St. Louis to Panama flights?

Historically, flights departing at night are less likely to be delayed, whereas flights leaving at night tend to experience delays more often.

What day of the week experiences the fewest flight delays on this route?

Thursday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated July 28, 2026.
Read reviews from past customers who have flown Delta,Copa Airlines, andUnited Airlines from St. Louis to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.8
Good
8,482 reviews

Overall

7.8

Comfort

7.8

Crew

8.5

Boarding

8.1

Food

7.2

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
Delta
7.8
Good
8,482 reviews
Delta
7.8
Good
8,482 reviews

Overall

7.8

Comfort

7.8

Crew

8.5

Boarding

8.1

Food

7.2

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
Copa Airlines
7.6
Good
1,559 reviews
Delta
7.8
Good
8,482 reviews

Overall

7.8

Comfort

7.8

Crew

8.5

Boarding

8.1

Food

7.2

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
United Airlines
7.4
Good
10,045 reviews
Delta
7.8
Good
8,482 reviews

Overall

7.8

Comfort

7.8

Crew

8.5

Boarding

8.1

Food

7.2

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
American Airlines
7.1
Good
11,840 reviews
Delta
7.8
Good
8,482 reviews

Overall

7.8

Comfort

7.8

Crew

8.5

Boarding

8.1

Food

7.2

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to Panama?

    For a flight from St. Louis to Panama, you will be flying from Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • How long is the flight from St. Louis to Panama?

    There are many flights that can get you from St. Louis to Panama in 12h 31m. Fly via United Airlines to get the fastest option. There are 2159 mi between St. Louis and Panama.

  • Can I find deals for flights from St. Louis to Panama that include hotel bookings?

    Yes. In addition to deals on St. Louis to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama.

  • Can I find deals for business class flights from St. Louis to Panama?

    Yes. Cheapflights offers flight deals from St. Louis to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Panama?

    Currently, April is the cheapest month in which you can book a flight from St. Louis to Panama (average of $495). Flying from St. Louis to Panama in June is currently the most expensive (average of $900). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 4 airlines flying from St. Louis to Panama

Discover the top 4 airlines that operate flights from St. Louis to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$393Average$590FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$393Average$607FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$446Average$719FlexibilityNo cancel feeOn-time70%
DeltaCheapest$481Average$702FlexibilityNo cancel feeOn-timeN/A

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