HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$399+ Cheap flights from Madrid, Spain (MAD) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — PTY
May 4 — May 111
Sun 5/4
Sun 5/11
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Madrid to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Madrid Barajas to Panama City Tocumen Intl are usually found in March or September, booked 44 days in advance, depart on a Monday or Thursday and return on a Tuesday

Cheap flight deals from Madrid to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$657
(United Airlines)

One-way from

$399
(British Airways)

Popular in

December

Cheapest in

March

Average price

$816

Good round-trip deal

$956 or less

Good one-way deal

$557 or less
Provider with most accurate pricing for Madrid Barajas-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Madrid Barajas-Panama City Tocumen Intl flights.
Search Deals
From Madrid Barajas to Panama City Tocumen Intl
Search Deals
One-way flight from Madrid Barajas to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($75 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($26 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2025
Search Deals
Price to beat on a round-trip flight from Madrid Barajas to Panama City Tocumen Intl.
Search Deals
Price to beat on a one-way flight from Madrid Barajas to Panama City Tocumen Intl.
Search Deals

Find flight deals from Madrid to Panama City

Cheapest flights from Madrid to Panama City
Explore the most affordable flight options available from Madrid to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.

This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/912:45 pmMAD - PTY
2 stops46h 20mUnited Airlines
Sun 5/2510:55 pmPTY - MAD
1 stop27h 05mUnited Airlines
Deal found 4/29$657
This KLM deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/178:25 pmMAD - PTY
1 stop27h 25mKLM
Tue 6/106:50 pmPTY - MAD
1 stop14h 35mKLM
Deal found 4/29$660
This KLM deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1110:20 amMAD - PTY
1 stop37h 30mMultiple Airlines
Mon 9/227:55 pmPTY - MAD
1 stop13h 50mMultiple Airlines
Deal found 4/29$661
This Avianca deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/191:30 amMAD - PTY
1 stop15h 40mAvianca
Wed 10/293:19 amPTY - MAD
1 stop13h 16mAvianca
Deal found 4/29$696
This Air Europa deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/23:10 pmMAD - PTY
Nonstop10h 35mAir Europa
Fri 11/289:30 pmPTY - MAD
Nonstop9h 35mAir Europa
Deal found 4/29$697
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2112:40 pmMAD - PTY
2 stops55h 14mDelta
Wed 9/32:12 pmPTY - MAD
2 stops34h 38mDelta
Deal found 4/29$744
This British Airways deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2512:00 pmMAD - PTY
Nonstop10h 40mIberia
Mon 9/155:20 pmPTY - MAD
Nonstop10h 05mIberia
Deal found 4/29$764
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/205:30 pmMAD - PTY
2 stops25h 55mAmerican Airlines
Thu 10/301:50 pmPTY - MAD
2 stops22h 40mAmerican Airlines
Deal found 4/29$952
This Turkish Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/56:20 pmMAD - PTY
2 stops31h 00mTurkish Airlines
Fri 8/89:55 pmPTY - MAD
1 stop32h 40mTurkish Airlines
Deal found 4/29$1,086

Cheapflights Fare Finder

Customize your flight search to find flights from Madrid to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
Use the filters below to find and compare flights from Madrid to Panama City that are best for you.

Fly from

Madrid

Fly to

Panama City

Route

Depart

Return

Price

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Fri 5/9

12:45 pm-4:05 am

2 stops46h 20m

Panama City Tocumen Intl

Sun 5/25

10:55 pm-9:00 am

1 stop27h 05m

$657

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sat 5/17

8:25 pm-4:50 pm

1 stop27h 25m

Panama City Tocumen Intl

Tue 6/10

6:50 pm-4:25 pm

1 stop14h 35m

$660

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 9/11

10:20 am-4:50 pm

1 stop37h 30m

Panama City Tocumen Intl

Mon 9/22

7:55 pm-4:45 pm

1 stop13h 50m

$661

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sun 10/19

1:30 am-10:10 am

1 stop15h 40m

Panama City Tocumen Intl

Wed 10/29

3:19 am-10:35 pm

1 stop13h 16m

$696

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 6/19

3:05 pm-6:40 pm

Nonstop10h 35m

Panama City Tocumen Intl

Tue 7/8

8:25 pm-1:15 pm

Nonstop9h 50m

$731

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 8/21

10:05 am-12:54 pm

1 stop33h 49m

Panama City Tocumen Intl

Thu 9/4

2:12 pm-7:50 am

2 stops34h 38m

$744

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Mon 8/25

12:00 pm-3:40 pm

Nonstop10h 40m

Panama City Tocumen Intl

Mon 9/15

5:20 pm-10:25 am

Nonstop10h 05m

$764

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Mon 10/20

5:30 pm-12:25 pm

2 stops25h 55m

Panama City Tocumen Intl

Thu 10/30

1:50 pm-6:30 pm

2 stops22h 40m

$952

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Tue 8/5

6:20 pm-6:20 pm

2 stops31h 00m

Panama City Tocumen Intl

Fri 8/8

9:55 pm-1:35 pm

1 stop32h 40m

$1,086

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Mon 5/5

12:00 pm-4:05 pm

Nonstop11h 05m

$399

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 15 results
1
2

Compare providers for flights from Madrid to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Madrid to Panama City in April.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
Kiwi.comPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Madrid-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Madrid-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Madrid-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Madrid-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Madrid-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Madrid to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Madrid with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Madrid to Panama City

How far ahead should I book a flight from Madrid to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Madrid to Panama City. Price data was last updated on April 25, 2025.

The price you pay for your flight from Madrid to Panama City may vary depending on when you book. For the best chance of a lower fare, look to book 44 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Madrid to Panama City?

Currently, October is the cheapest month in which you can book a flight from Madrid to Panama City (average of $478). Flying from Madrid to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MAD to PTY?

Find hourly flight availability from Madrid to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 29, 2025.

It’s optimal to fly from Madrid to Panama City in the morning. By choosing this option you can save up to 3% on the cost of your flight, compared to a flight at noon.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated April 29, 2025.
Peruse reviews from past customers who have flown with Delta, KLM and United Airlines from Madrid to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,936 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
4.0
Okay

Peter,Oct 2023

MSP - GEG

The amount of carry on is put of control. We were in group 3 boarding and there was no room in upper storage for our 1 bag (between 2 people) Just because we can’t afford to up grade our seats… $2000 more. We get penaltized. Make us feel less than
Delta
8.0
Very good
7,936 reviews
Delta
8.0
Very good
7,936 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
4.0
Okay

Peter,Oct 2023

MSP - GEG

The amount of carry on is put of control. We were in group 3 boarding and there was no room in upper storage for our 1 bag (between 2 people) Just because we can’t afford to up grade our seats… $2000 more. We get penaltized. Make us feel less than
KLM
7.8
Good
1,333 reviews
Delta
8.0
Very good
7,936 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
4.0
Okay

Peter,Oct 2023

MSP - GEG

The amount of carry on is put of control. We were in group 3 boarding and there was no room in upper storage for our 1 bag (between 2 people) Just because we can’t afford to up grade our seats… $2000 more. We get penaltized. Make us feel less than
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,936 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
4.0
Okay

Peter,Oct 2023

MSP - GEG

The amount of carry on is put of control. We were in group 3 boarding and there was no room in upper storage for our 1 bag (between 2 people) Just because we can’t afford to up grade our seats… $2000 more. We get penaltized. Make us feel less than
Turkish Airlines
7.3
Good
3,788 reviews
Delta
8.0
Very good
7,936 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
4.0
Okay

Peter,Oct 2023

MSP - GEG

The amount of carry on is put of control. We were in group 3 boarding and there was no room in upper storage for our 1 bag (between 2 people) Just because we can’t afford to up grade our seats… $2000 more. We get penaltized. Make us feel less than
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,936 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
4.0
Okay

Peter,Oct 2023

MSP - GEG

The amount of carry on is put of control. We were in group 3 boarding and there was no room in upper storage for our 1 bag (between 2 people) Just because we can’t afford to up grade our seats… $2000 more. We get penaltized. Make us feel less than

Related info for your journey

Find useful and relevant information for your journey from Madrid to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Madrid to Panama City?

    To fly from Madrid to Panama City, you need to book a flight from Barajas (MAD) to Tocumen Intl (PTY). Nonstop flights to Panama City Tocumen Intl from Madrid Barajas take 10h 35m on average. When it comes time to book airfare, you have a few options: there are 4 outbound flights from Barajas to Tocumen Intl offered by 3 different airlines.

  • How popular is this Madrid to Panama City flight route?

    The Madrid Barajas to Panama City Tocumen Intl flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines flying from Madrid to Panama City round-trip?

    United Airlines, at $657, was found to be the cheapest airline from Madrid to Panama City.Alternate airlines to your destination round-trip include KLM and Avianca. United Airlines is 17% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Madrid to Panama City one-way?

    For one-way options, check prices for Iberia. According to our data, you can fly for as low as $399. Users have also found prices from $516 and $588 on Avianca and Air Europa, respectively.

  • What are the most reliable airlines from Madrid to Panama City?

    Consider Qatar Airways (70%), Iberia (70%) or EL AL (70%) when booking your flight. These represent the most reliable airlines when flying from Madrid to Panama City.

  • What are the cheapest flights from Madrid to Panama City?

    The cheapest flight price from Madrid to Panama City is $380. On average you can expect to pay $874. The most popular route, (Madrid Barajas - Panama City Tocumen Intl), can usually be booked for $663.

  • Can I find deals for flights from Madrid to Panama City that include hotel bookings?

    Yes. In addition to deals on Madrid to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Madrid to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Panama City.

  • Can I find deals for business class flights from Madrid to Panama City?

    Yes. Cheapflights offers flight deals from Madrid to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Madrid to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Madrid to Panama City (average of $478). Flying from Madrid to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Madrid to Panama City

Discover the top 3 airlines that operate flights from Madrid to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$582Average$1,069FlexibilityNo cancel feeOn-time71%
Air EuropaCheapest$618Average$882FlexibilityNo cancel feeOn-time83%
IberiaCheapest$644Average$797FlexibilityNo cancel feeOn-time77%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.