How popular is this Madrid to Panama City flight route?

The Madrid Barajas to Panama City Tocumen Intl flight path was viewed by 5 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

How long is the flight from Madrid to Panama City?

United Airlines and Air Europa can get you from Madrid to Panama City in just under 10h 35m. Your travel time can differ by up to 28h 15m. Madrid and Panama City are separated by a distance of 5065 mi. This flight may include one or multiple stops.

What are the cheapest airlines flying from Madrid to Panama City round-trip?

Avianca, at $545, was found to be the cheapest airline from Madrid to Panama City.Alternate airlines to your destination round-trip include Air Europa and Iberia. Avianca is 32% cheaper than the average price of flights available within the next 90 days to this destination.

What are the cheapest airlines to fly from Madrid to Panama City one-way?

For one-way options, check prices for Air Europa. According to our data, you can fly for as low as $388. Users have also found prices from $427 and $509 on Iberia and Avianca, respectively.

What is the cheapest day to fly from Madrid to Panama City?

Travelers seeking maximum savings on their Madrid to Panama City flight should consider departing on Sunday afternoons when fares are most often at their lowest. Thursday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Madrid to Panama City

The most flights from MAD to PTY are scheduled on a Monday (10 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (5 on average).

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the cheapest flights from Madrid to Panama City?

The cheapest flight price from Madrid to Panama City is $334. On average you can expect to pay $733. The most popular route, (Madrid Barajas - Panama City Tocumen Intl), can usually be booked for $669.

What are the most reliable airlines from Madrid to Panama City?

Consider Pascan (91%), Qatar Airways (83%) or Iberia (83%) when booking your flight. These represent the most reliable airlines when flying from Madrid to Panama City.

What are the most popular airlines that fly from Madrid to Panama City?

The most popular airlines flying from Madrid to Panama City are Avianca, Iberia and Air Europa. Something to consider prior to booking your flight.

What is the cheapest day to fly round-trip from Madrid to Panama City?

Wednesday flights are found to be more expensive to fly from Madrid to Panama City. This shouldn’t discourage you from searching, as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to Panama City.

How far in advance should I book a flight from Madrid to Panama City?

To save on the cost of your flight from Madrid to Panama City, book at least 36 days before your planned departure. Booking around this time can save you about 26% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $713 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $880.

What is the cheapest month to fly from Madrid to Panama City?

Our data shows that March tends to be the cheapest month to fly to Panama City from Madrid. Users have commonly found prices around $807 for the month, but tickets can be as low as $542. Due to multiple factors, prepare for potentially higher prices in December.

What airports do I use to fly from Madrid to Panama City?

To fly from Madrid to Panama City, you need to book a flight from Barajas (MAD) to Tocumen Intl (PTY). Nonstop flights to Panama City Tocumen Intl from Madrid Barajas take 10h 35m on average. When it comes time to book airfare, you have a few options: there are 7 outbound flights from Barajas to Tocumen Intl offered by 3 different airlines.

Can I find deals for flights from Madrid to Panama City that include hotel bookings?

Yes. In addition to deals on Madrid to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Madrid to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Panama City.

Can I find deals for business class flights from Madrid to Panama City?

Yes. Cheapflights offers flight deals from Madrid to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$345+ Flights from Madrid, Spain to Panama City

Q: How much does it cost to fly round-trip from Madrid to Panama City?

Airfare is typical for this route at the moment. Madrid to Panama City flights typically cost between $649 and $783 in February. The cheapest round-trip price found within the last 3 days was $654 on Multiple Airlines (Feb 8-Feb 17).

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Madrid Barajas to Panama City Tocumen Intl are usually found in March or February, booked 35 days in advance, depart on a Wednesday or Sunday and return on a Tuesday

Cheap flight deals from Madrid to Panama City

Round-trip from	$654 (KLM)
One-way from	$345 (Orbitz)
Popular in	December
Cheapest in	March
Average price	$697
Good round-trip deal	$677 or less
Good one-way deal	$378 or less

From Madrid Barajas to Panama City Tocumen Intl

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One-way flight from Madrid Barajas to Panama City Tocumen Intl

Search Deals

Highest demand for flights based on searches. 9% potential increase in price ($87 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($29 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in September 2025

Search Deals

Price to beat on a round-trip flight from Madrid Barajas to Panama City Tocumen Intl.

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Price to beat on a one-way flight from Madrid Barajas to Panama City Tocumen Intl.

Search Deals

Find flight deals from Madrid to Panama City

Cheapest flights from Madrid to Panama City
Explore the most affordable flight options available from Madrid to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Sat 9/208:25 pmMAD - PTY

1 stop27h 25mKLM

Mon 10/66:50 pmPTY - MAD

1 stop31h 40mKLM

Deal found 9/15

$648

Fri 10/103:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Fri 11/79:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Deal found 9/14

$669

Tue 9/236:00 amMAD - PTY

1 stop18h 45mAir France

Tue 10/2810:20 pmPTY - MAD

1 stop13h 20mAir France

Deal found 9/15

$678

Sun 10/123:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Sun 11/29:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Deal found 9/15

$682

Mon 11/246:45 pmMAD - PTY

1 stop31h 25mMultiple Airlines

Mon 12/16:45 pmPTY - MAD

1 stop22h 40mMultiple Airlines

Deal found 9/14

$686

Tue 9/166:00 amMAD - PTY

1 stop17h 50mKLM

Mon 9/296:50 pmPTY - MAD

1 stop31h 40mKLM

Deal found 9/15

$692

Sat 9/208:25 pmMAD - PTY

1 stop27h 25mKLM

Mon 9/296:50 pmPTY - MAD

1 stop31h 40mKLM

Deal found 9/14

$700

Mon 11/246:45 pmMAD - PTY

1 stop31h 25mAir France

Mon 12/13:37 pmPTY - MAD

1 stop35h 38mAir France

Deal found 9/15

$708

Sun 10/123:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Thu 10/309:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Deal found 9/15

$717

Sun 10/511:15 amMAD - PTY

2 stops33h 35mUnited Airlines

Sun 10/193:30 pmPTY - MAD

2 stops34h 30mUnited Airlines

Deal found 9/15

$726

Wed 10/2911:15 amMAD - PTY

2 stops32h 30mUnited Airlines

Wed 11/54:41 pmPTY - MAD

2 stops33h 19mUnited Airlines

Deal found 9/14

$728

Sun 12/143:10 pmMAD - PTY

Nonstop10h 35mAir Europa

Wed 12/179:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Deal found 9/15

$729

Best flights from Madrid to Panama City
Discover carefully curated flight deals from Madrid to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2025.

Sun 1/185:55 amMAD - PTY

2 stops38h 50mUnited Airlines

Sat 1/314:41 pmPTY - MAD

2 stops34h 34mUnited Airlines

Deal found 9/15

$655

Thu 1/2911:15 amMAD - PTY

2 stops35h 52mUnited Airlines

Mon 3/24:41 pmPTY - MAD

2 stops34h 34mUnited Airlines

Deal found 9/15

$667

Wed 2/1111:15 amMAD - PTY

2 stops38h 23mUnited Airlines

Thu 2/1911:35 amPTY - MAD

2 stops39h 40mUnited Airlines

Deal found 9/14

$667

Fri 2/1311:15 amMAD - PTY

2 stops35h 52mUnited Airlines

Sun 2/224:41 pmPTY - MAD

2 stops34h 34mUnited Airlines

Deal found 9/15

$669

Wed 10/2911:15 amMAD - PTY

2 stops32h 30mUnited Airlines

Wed 11/54:41 pmPTY - MAD

2 stops33h 19mUnited Airlines

Deal found 9/14

$728

Mon 10/1311:15 amMAD - PTY

2 stops33h 59mUnited Airlines

Mon 10/209:45 amPTY - MAD

1 stop16h 15mUnited Airlines

Deal found 9/15

$728

Thu 10/211:15 amMAD - PTY

2 stops33h 59mUnited Airlines

Tue 10/1410:00 amPTY - MAD

2 stops39h 05mUnited Airlines

Deal found 9/14

$728

Thu 10/911:15 amMAD - PTY

2 stops38h 22mUnited Airlines

Thu 10/169:45 amPTY - MAD

1 stop16h 15mUnited Airlines

Deal found 9/15

$728

Mon 10/2011:15 amMAD - PTY

2 stops38h 22mUnited Airlines

Fri 11/288:55 amPTY - MAD

2 stops41h 10mUnited Airlines

Deal found 9/15

$728

Mon 11/2411:05 amMAD - PTY

2 stops33h 40mUnited Airlines

Mon 12/14:41 pmPTY - MAD

2 stops33h 24mUnited Airlines

Deal found 9/14

$740

Last-minute flights from Madrid to Panama City
Discover last-minute flight deals from Madrid to Panama City. Data last updated September 15, 2025 and is based on user searches.

Tue 9/166:00 amMAD - PTY

1 stop17h 50mKLM

Mon 9/296:50 pmPTY - MAD

1 stop31h 40mKLM

Deal found 9/15

$692

Tue 9/1610:05 amMAD - PTY

1 stop14h 40mMultiple Airlines

Sun 9/216:50 pmPTY - MAD

1 stop21h 35mMultiple Airlines

Deal found 9/15

$736

Sat 9/208:25 pmMAD - PTY

1 stop27h 25mKLM

Mon 10/66:50 pmPTY - MAD

1 stop31h 40mKLM

Deal found 9/15

$648

Sat 9/208:25 pmMAD - PTY

1 stop27h 25mKLM

Mon 9/296:50 pmPTY - MAD

1 stop31h 40mKLM

Deal found 9/14

$700

Tue 9/236:00 amMAD - PTY

1 stop18h 45mAir France

Tue 10/2810:20 pmPTY - MAD

1 stop13h 20mAir France

Deal found 9/15

$678

Sun 10/511:15 amMAD - PTY

2 stops33h 35mUnited Airlines

Sun 10/193:30 pmPTY - MAD

2 stops34h 30mUnited Airlines

Deal found 9/15

$726

Thu 10/911:15 amMAD - PTY

2 stops38h 22mUnited Airlines

Thu 10/163:30 pmPTY - MAD

2 stops57h 50mUnited Airlines

Deal found 9/15

$734

Thu 10/911:15 amMAD - PTY

2 stops38h 22mUnited Airlines

Mon 10/209:45 amPTY - MAD

2 stops24h 00mUnited Airlines

Deal found 9/15

$738

Fri 10/103:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Fri 11/79:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Deal found 9/14

$669

Sun 10/123:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Sun 11/29:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Deal found 9/15

$682

Sun 10/123:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Thu 10/309:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Deal found 9/15

$717

Wed 10/2911:15 amMAD - PTY

2 stops32h 30mUnited Airlines

Wed 11/54:41 pmPTY - MAD

2 stops33h 19mUnited Airlines

Deal found 9/14

$728

One-way flights from Madrid to Panama City
Search for one-way flight options from Madrid to Panama City. Find affordable one-way fares based on user searches. Data last updated September 15, 2025.

Wed 10/2911:40 amMAD - PTY

Nonstop11h 05mIberia

Deal found 9/14

$345

Sun 9/217:10 amMAD - PTY

3 stops26h 30mMultiple Airlines

Deal found 9/13

$346

Sun 10/53:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Deal found 9/14

$379

Sun 11/23:10 pmMAD - PTY

Nonstop10h 35mAir Europa

Deal found 9/14

$388

Mon 9/2212:00 pmMAD - PTY

Nonstop10h 40mIberia

Deal found 9/15

$427

Sun 9/213:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Deal found 9/13

$437

Wed 10/158:15 pmMAD - PTY

2 stops54h 45mMultiple Airlines

Deal found 9/14

$469

Wed 10/229:00 pmMAD - PTY

3 stops52h 20mMultiple Airlines

Deal found 9/14

$473

Sun 1/1110:05 amMAD - PTY

2 stops39h 45mMultiple Airlines

Deal found 9/14

$474

Cheapflights Fare Finder

Use the filters below to find and compare flights from Madrid to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sun 1/18

5:55 am-2:45 pm

2 stops38h 50m

Panama City Tocumen Intl

Sat 1/31

4:41 pm-9:15 am

2 stops34h 34m

$655

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 1/29

11:15 am-5:07 pm

2 stops35h 52m

Panama City Tocumen Intl

Mon 3/2

4:41 pm-9:15 am

2 stops34h 34m

$667

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Wed 2/11

11:15 am-7:38 pm

2 stops38h 23m

Panama City Tocumen Intl

Thu 2/19

11:35 am-9:15 am

2 stops39h 40m

$667

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Fri 2/13

11:15 am-5:07 pm

2 stops35h 52m

Panama City Tocumen Intl

Sun 2/22

4:41 pm-9:15 am

2 stops34h 34m

$669

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Wed 10/29

11:15 am-1:45 pm

2 stops32h 30m

Panama City Tocumen Intl

Wed 11/5

4:41 pm-8:00 am

2 stops33h 19m

$728

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Mon 10/13

11:15 am-2:14 pm

2 stops33h 59m

Panama City Tocumen Intl

Mon 10/20

9:45 am-9:00 am

1 stop16h 15m

$728

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 10/2

11:15 am-2:14 pm

2 stops33h 59m

Panama City Tocumen Intl

Tue 10/14

10:00 am-8:05 am

2 stops39h 05m

$728

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 10/9

11:15 am-6:37 pm

2 stops38h 22m

Panama City Tocumen Intl

Thu 10/16

9:45 am-9:00 am

1 stop16h 15m

$728

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Mon 10/20

11:15 am-6:37 pm

2 stops38h 22m

Panama City Tocumen Intl

Fri 11/28

8:55 am-8:05 am

2 stops41h 10m

$728

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Mon 11/24

11:05 am-2:45 pm

2 stops33h 40m

Panama City Tocumen Intl

Mon 12/1

4:41 pm-8:05 am

2 stops33h 24m

$740

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 20 results

The best insider tips for Madrid to Panama City flights

Cheapflights partnered with top experts to bring you the best recommendations for your Madrid to Panama City trip

Airports

MAD

Many airlines at MAD offer automated kiosks for quick check-in, including Iberia. Security lines can be crowded but move quickly.

PTY

At PTY, Uber is often the fastest and less expensive transport option to Panama City, compared to taxis.

Our travel experts

Lori Zaino

Expert on MAD

Taryn White

Expert on PTY

Best time to book a flight from Madrid to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Madrid with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Madrid to Panama City

Prices

Airlines

How far ahead should I book a flight from Madrid to Panama City?

The price you pay for your flight from Madrid to Panama City may vary depending on when you book. For the best chance of a lower fare, look to book 35 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Madrid to Panama City?

Currently, October is the cheapest month in which you can book a flight from Madrid to Panama City (average of $478). Flying from Madrid to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MAD to PTY?

It’s optimal to fly from Madrid to Panama City in the morning. By choosing this option you can save up to 2% on the cost of your flight, compared to a flight at noon.

How much does it cost to fly round-trip from Madrid to Panama City?

Reviews of airlines servicing Panama City

Get a feel of what it's like to fly with Air Europa, Iberia, and Avianca from Madrid to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Air Europa

7.0

Good

556 reviews

Reviews

1 / 10

8.0

Excellent

Christina,Jun 2025

ALC - MAD

It would be nice to have free messaging wifi on a trans Atlantic flight

Air Europa

7.0

Good

556 reviews

Air Europa

7.0

Good

556 reviews

Reviews

1 / 10

8.0

Excellent

Christina,Jun 2025

ALC - MAD

It would be nice to have free messaging wifi on a trans Atlantic flight

Iberia

7.0

Good

2,924 reviews

Air Europa

7.0

Good

556 reviews

Reviews

1 / 10

8.0

Excellent

Christina,Jun 2025

ALC - MAD

It would be nice to have free messaging wifi on a trans Atlantic flight

Avianca

6.7

Okay

2,435 reviews

Air Europa

7.0

Good

556 reviews

Reviews

1 / 10

8.0

Excellent

Christina,Jun 2025

ALC - MAD

It would be nice to have free messaging wifi on a trans Atlantic flight

Related info for your journey

What airports do I use to fly from Madrid to Panama City?
To fly from Madrid to Panama City, you need to book a flight from Barajas (MAD) to Tocumen Intl (PTY). Nonstop flights to Panama City Tocumen Intl from Madrid Barajas take 10h 35m on average. When it comes time to book airfare, you have a few options: there are 7 outbound flights from Barajas to Tocumen Intl offered by 3 different airlines.
How popular is this Madrid to Panama City flight route?
The Madrid Barajas to Panama City Tocumen Intl flight path was viewed by 5 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Madrid to Panama City?
United Airlines and Air Europa can get you from Madrid to Panama City in just under 10h 35m. Your travel time can differ by up to 28h 15m. Madrid and Panama City are separated by a distance of 5065 mi. This flight may include one or multiple stops.
What are the cheapest airlines flying from Madrid to Panama City round-trip?
Avianca, at $545, was found to be the cheapest airline from Madrid to Panama City.Alternate airlines to your destination round-trip include Air Europa and Iberia. Avianca is 32% cheaper than the average price of flights available within the next 90 days to this destination.
What are the cheapest airlines to fly from Madrid to Panama City one-way?
For one-way options, check prices for Air Europa. According to our data, you can fly for as low as $388. Users have also found prices from $427 and $509 on Iberia and Avianca, respectively.
What are the most reliable airlines from Madrid to Panama City?
Consider Pascan (91%), Qatar Airways (83%) or Iberia (83%) when booking your flight. These represent the most reliable airlines when flying from Madrid to Panama City.
What are the cheapest flights from Madrid to Panama City?
The cheapest flight price from Madrid to Panama City is $334. On average you can expect to pay $733. The most popular route, (Madrid Barajas - Panama City Tocumen Intl), can usually be booked for $669.
Can I find deals for flights from Madrid to Panama City that include hotel bookings?
Yes. In addition to deals on Madrid to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Madrid to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Panama City.
Can I find deals for business class flights from Madrid to Panama City?
Yes. Cheapflights offers flight deals from Madrid to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Madrid to Panama City?
Currently, October is the cheapest month in which you can book a flight from Madrid to Panama City (average of $478). Flying from Madrid to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Panama City Tocumen Intl Airport car rentals

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Ancón car rentals

Calidonia car rentals

Parque Lefevre car rentals

Bethania car rentals

Santa Ana car rentals

Juan Diaz car rentals

Pueblo Nuevo car rentals

Other flights to Panama City

Top 3 airlines flying from Madrid to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$545	Average$1,129	FlexibilityNo cancel fee	On-time71%
Air Europa	Cheapest$630	Average$867	FlexibilityNo cancel fee	On-time83%
Iberia	Cheapest$644	Average$793	FlexibilityNo cancel fee	On-time77%

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$345+ Cheap flights from Madrid, Spain (MAD) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/29. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Madrid to Panama City with Cheapflights

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3. Compare prices and book

Cheapflights Tip: The best prices from Madrid Barajas to Panama City Tocumen Intl are usually found in March or February, booked 35 days in advance, depart on a Wednesday or Sunday and return on a Tuesday

Cheap flight deals from Madrid to Panama City

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Madrid to Panama City

Cheapest flights from Madrid to Panama CityExplore the most affordable flight options available from Madrid to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Explore the most affordable flight options available from Madrid to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Madrid to Panama City that are best for you.

The best insider tips for Madrid to Panama City flights

Cheapflights partnered with top experts to bring you the best recommendations for your Madrid to Panama City trip

Airports

MAD

PTY

Our travel experts

Best time to book a flight from Madrid to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Madrid with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Madrid to Panama City

How far ahead should I book a flight from Madrid to Panama City?

What is the cheapest month to book a flight from Madrid to Panama City?

What is the cheapest time of day to fly from MAD to PTY?

How much does it cost to fly round-trip from Madrid to Panama City?

Weekly flight availability from Madrid to Panama City

Reviews of airlines servicing Panama City

Get a feel of what it's like to fly with Air Europa, Iberia, and Avianca from Madrid to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Madrid to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Madrid to Panama City?

How popular is this Madrid to Panama City flight route?

How long is the flight from Madrid to Panama City?

What are the cheapest airlines flying from Madrid to Panama City round-trip?

What are the cheapest airlines to fly from Madrid to Panama City one-way?

What are the most reliable airlines from Madrid to Panama City?

What are the cheapest flights from Madrid to Panama City?

Can I find deals for flights from Madrid to Panama City that include hotel bookings?

How can I find direct flights from Madrid to Panama City?

Can I find deals for business class flights from Madrid to Panama City?

What is the cheapest month to book a flight from Madrid to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.

Top 3 airlines flying from Madrid to Panama City

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Cheapest flights from Madrid to Panama City
Explore the most affordable flight options available from Madrid to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.