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Panama City

$341+ Cheap flights from Madrid, Spain (MAD) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/14. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — PTY
Apr 15 — Apr 221
Wed 4/15
Wed 4/22
1 adult, Economy
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Find cheap flights from Madrid to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

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Cheapflights Tip: The best prices from Madrid Barajas to Panama City Tocumen Intl are usually found in September or May, booked 57 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Cheap flight deals from Madrid to Panama City

Cheapest flights from Madrid to Panama City
Explore the most affordable flight options available from Madrid to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.

This Avianca deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/218:10 am
MAD
-
PTY
1 stop13h 05m
Avianca
Thu 6/254:25 am
PTY
-
MAD
1 stop12h 55m
Avianca
Deal found 3/15$675
This Air Europa deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/183:05 pm
MAD
-
PTY
Nonstop10h 35m
Air Europa
Thu 6/258:25 pm
PTY
-
MAD
Nonstop9h 50m
Air Europa
Deal found 3/15$677
This Air Europa deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/233:05 pm
MAD
-
PTY
Nonstop10h 35m
Air Europa
Thu 5/78:25 pm
PTY
-
MAD
Nonstop9h 50m
Air Europa
Deal found 3/14$680
This deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/223:05 pm
MAD
-
PTY
Nonstop10h 35m
Air Europa
Wed 4/298:25 pm
PTY
-
MAD
Nonstop9h 50m
Air Europa
Deal found 3/14$683
This Air Europa deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/103:05 pm
MAD
-
PTY
Nonstop10h 35m
Air Europa
Mon 5/258:25 pm
PTY
-
MAD
Nonstop9h 50m
Air Europa
Deal found 3/13$684
This FlightHub deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/33:05 pm
MAD
-
PTY
Nonstop10h 35m
Air Europa
Sun 5/108:25 pm
PTY
-
MAD
Nonstop9h 50m
Air Europa
Deal found 3/11$686
This Air Europa deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/203:10 pm
MAD
-
PTY
Nonstop10h 35m
Air Europa
Sun 5/108:25 pm
PTY
-
MAD
Nonstop9h 50m
Air Europa
Deal found 3/12$687
This FlightHub deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/303:05 pm
MAD
-
PTY
Nonstop10h 35m
Air Europa
Tue 5/58:25 pm
PTY
-
MAD
Nonstop9h 50m
Air Europa
Deal found 3/12$689
This Air Europa deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/23:05 pm
MAD
-
PTY
Nonstop10h 35m
Air Europa
Mon 5/188:25 pm
PTY
-
MAD
Nonstop9h 50m
Air Europa
Deal found 3/11$690
This Avianca deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/264:20 pm
MAD
-
PTY
1 stop14h 20m
Avianca
Sun 11/82:55 am
PTY
-
MAD
1 stop14h 25m
Avianca
Deal found 3/12$705
This Avianca deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:35 am
MAD
-
PTY
1 stop24h 05m
Avianca
Sun 11/292:55 am
PTY
-
MAD
1 stop14h 25m
Avianca
Deal found 3/14$706
This Trip.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/273:05 pm
MAD
-
PTY
Nonstop10h 35m
Air Europa
Mon 5/48:25 pm
PTY
-
MAD
Nonstop9h 50m
Air Europa
Deal found 3/13$707

Find flight deals from Madrid to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$675
(Avianca)

One-way from

$341
(Kiwi.com)

Popular in

December

Cheapest in

September

Average price

$785

Good round-trip deal

$758 or less

Good one-way deal

$350 or less
Provider with most accurate pricing for Madrid Barajas-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Madrid Barajas-Panama City Tocumen Intl flights.
Search Deals
From Madrid Barajas to Panama City Tocumen Intl
Search Deals
One-way flight from Madrid Barajas to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($114 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals
Price to beat on a round-trip flight from Madrid Barajas to Panama City Tocumen Intl.
Search Deals
Price to beat on a one-way flight from Madrid Barajas to Panama City Tocumen Intl.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Madrid to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from Madrid to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Wed 5/13

3:55 pm-8:00 pm

Nonstop11h 05m

Panama City Tocumen Intl

Sun 5/17

9:30 pm-2:20 pm

Nonstop9h 50m

$748

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sat 9/12

2:35 pm-12:56 pm

2 stops53h 21m

Panama City Tocumen Intl

Sat 10/3

2:21 pm-6:20 am

2 stops32h 59m

$768

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sat 9/12

6:00 am-4:50 pm

1 stop17h 50m

Panama City Tocumen Intl

Sat 10/3

6:50 pm-7:35 pm

1 stop17h 45m

$770
Quickest round-trip

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 4/9

3:05 pm-6:40 pm

Nonstop10h 35m

Panama City Tocumen Intl

Thu 4/23

8:25 pm-1:15 pm

Nonstop9h 50m

$788

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sat 4/25

5:55 am-2:14 pm

2 stops39h 19m

Panama City Tocumen Intl

Sat 5/2

10:00 am-8:05 am

2 stops39h 05m

$949

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 4/30

6:05 am-2:14 pm

2 stops39h 09m

Panama City Tocumen Intl

Thu 5/7

3:30 pm-8:05 am

2 stops33h 35m

$954

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sun 5/10

11:15 am-4:12 pm

2 stops35h 57m

Panama City Tocumen Intl

Sun 5/17

9:45 am-9:00 am

1 stop16h 15m

$967

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 4/30

6:20 am-7:31 pm

2 stops20h 11m

Panama City Tocumen Intl

Tue 5/5

3:30 pm-8:05 am

2 stops33h 35m

$972

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Tue 4/7

6:20 am-7:31 pm

2 stops20h 11m

Panama City Tocumen Intl

Tue 4/14

9:45 am-9:00 am

1 stop16h 15m

$984

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Tue 3/31

6:20 am-7:31 pm

2 stops20h 11m

Panama City Tocumen Intl

Sun 4/12

3:30 pm-8:05 am

2 stops33h 35m

$989

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/11

Showing 1-10 of 23 resultsSorted by cheapest first
1
2
3

Compare providers for flights from Madrid to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Madrid to Panama City in March.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
Kiwi.comPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Madrid-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Madrid-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Madrid-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Madrid-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Madrid-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Madrid to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Madrid with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Madrid to Panama City

How far ahead should I book a flight from Madrid to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Madrid to Panama City. Price data was last updated on March 13, 2026.

The price you pay for your flight from Madrid to Panama City may vary depending on when you book. For the best chance of a lower fare, look to book 57 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Madrid to Panama City?

Currently, October is the cheapest month in which you can book a flight from Madrid to Panama City (average of $571). Flying from Madrid to Panama City in December is currently the most expensive (average of $786). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MAD to PTY?

Find hourly flight availability from Madrid to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 16, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Madrid to Panama City as you normally would.

How much does it cost to fly round-trip from Madrid to Panama City?

The best insider tips for Madrid to Panama City flights

AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Madrid to Panama City trip
Our travel experts
Lori Zaino

Lori Zaino

Expert on MAD

US-born but now based in Spain, Lori's visited 60 countries---and written about them for publications like CNN, Forbes, The Points Guy, NBC, and TripAdvisor. She loves combining affordable adventures with luxury travel experiences and feels equally at home salsa dancing in Colombia, sipping wine in a French castle, or backpacking through Malaysia.

Read more
Taryn White

Taryn White

Expert on PTY

Taryn White is a freelance travel writer, digital creator, and travel advisor who has visited nearly 100 countries and all 50 states. She’s familiar with many airports and enjoys beach hopping, boutique hotels, spa experiences, and exploring local culture. Her work has appeared in Travel + Leisure, Condé Nast Traveler, National Geographic, Smithsonian Magazine, AFAR, and more.

Read more

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated March 16, 2026.
Get a feel of what it's like to fly with Iberia,Air Europa, andAvianca from Madrid to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Iberia
7.0
Good
3,136 reviews

Food

6.4

Boarding

7.1

Overall

7.0

Entertainment

6.6

Comfort

6.8

Crew

7.7

Reviews

1 / 20
10.0
Excellent

Sylvie,Dec 2025

MAD - DSS

No space ,no confortable, and not organised at all àd very tiring and I booked my seat in advance
Iberia
7.0
Good
3,136 reviews
Iberia
7.0
Good
3,136 reviews

Food

6.4

Boarding

7.1

Overall

7.0

Entertainment

6.6

Comfort

6.8

Crew

7.7

Reviews

1 / 20
10.0
Excellent

Sylvie,Dec 2025

MAD - DSS

No space ,no confortable, and not organised at all àd very tiring and I booked my seat in advance
Air Europa
6.9
Okay
595 reviews
Iberia
7.0
Good
3,136 reviews

Food

6.4

Boarding

7.1

Overall

7.0

Entertainment

6.6

Comfort

6.8

Crew

7.7

Reviews

1 / 20
10.0
Excellent

Sylvie,Dec 2025

MAD - DSS

No space ,no confortable, and not organised at all àd very tiring and I booked my seat in advance
Avianca
6.5
Okay
2,498 reviews
Iberia
7.0
Good
3,136 reviews

Food

6.4

Boarding

7.1

Overall

7.0

Entertainment

6.6

Comfort

6.8

Crew

7.7

Reviews

1 / 20
10.0
Excellent

Sylvie,Dec 2025

MAD - DSS

No space ,no confortable, and not organised at all àd very tiring and I booked my seat in advance

Related info for your journey

Find useful and relevant information for your journey from Madrid to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Madrid to Panama City?

    To fly from Madrid to Panama City, you need to book a flight from Barajas (MAD) to Tocumen Intl (PTY). Nonstop flights to Panama City Tocumen Intl from Madrid Barajas take 10h 35m on average. When it comes time to book airfare, you have a few options: there are 5 outbound flights from Barajas to Tocumen Intl offered by 3 different airlines.

  • How popular is this Madrid to Panama City flight route?

    The Madrid Barajas to Panama City Tocumen Intl flight path was viewed by 7 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Madrid to Panama City?

    Iberia, Delta, and KLM can get you from Madrid to Panama City in just under 11h 05m. Your travel time can differ by up to 42h 16m. Madrid and Panama City are separated by a distance of 5065 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Madrid to Panama City round-trip?

    Air Europa, at $640, was found to be the cheapest airline from Madrid to Panama City.Alternate airlines to your destination round-trip include Iberia and Avianca. Air Europa is 23% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Madrid to Panama City one-way?

    For one-way options, check prices for Avianca. According to our data, you can fly for as low as $332. Users have also found prices from $341 and $350 on Air Europa and Iberia, respectively.

  • What are the most reliable airlines from Madrid to Panama City?

    Consider Qatar Airways (62%), Iberia (62%) or EL AL (62%) when booking your flight. These represent the most reliable airlines when flying from Madrid to Panama City.

  • What are the cheapest flights from Madrid to Panama City?

    The cheapest flight price from Madrid to Panama City is $348. On average you can expect to pay $608. The most popular route, (Madrid Barajas - Panama City Tocumen Intl), can usually be booked for $689.

  • Can I find deals for flights from Madrid to Panama City that include hotel bookings?

    Yes. In addition to deals on Madrid to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Madrid to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Panama City.

  • Can I find deals for business class flights from Madrid to Panama City?

    Yes. Cheapflights offers flight deals from Madrid to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Madrid to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Madrid to Panama City (average of $571). Flying from Madrid to Panama City in December is currently the most expensive (average of $786). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Madrid to Panama City

Discover the top 3 airlines that operate flights from Madrid to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
Air EuropaCheapest$640Average$901FlexibilityNo cancel feeOn-time83%
IberiaCheapest$665Average$1,034FlexibilityNo cancel feeOn-time77%
AviancaCheapest$765Average$1,129FlexibilityNo cancel feeOn-time71%

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