Panama City

$396+ Cheap flights from Madrid, Spain (MAD) to Panama City (PTY)

MAD — PTY
Dec 10 — Dec 171
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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Madrid Barajas to Panama City Tocumen Intl are usually found in April or February, booked 84 days in advance, depart on a Saturday or Thursday and return on a Thursday

Cheap flight deals from Madrid to Panama City

Cheapest flights from Madrid to Panama City

Wed 11/256:00 am -
1 stop20h 20m
Sun 12/610:30 pm -
1 stop13h 15m
Deal found 11/5$712
Wed 11/256:00 am -
1 stop20h 20m
Sun 12/610:30 pm -
2 stops19h 05m
Deal found 11/5$743
Tue 11/243:50 pm -
2 stops23h 20m
Sun 12/64:10 pm -
1 stop34h 00m
Deal found 11/7$797
Sat 11/147:00 am -
3 stops28h 48m
Wed 11/186:45 pm -
2 stops18h 25m
Deal found 11/8$848
Sat 11/217:00 am -
3 stops28h 48m
Sun 11/294:18 pm -
2 stops17h 02m
Deal found 11/6$856
Fri 11/66:05 am -
3 stops29h 43m
Sat 11/76:45 pm -
1 stop18h 50m
Deal found 11/5$867
Wed 11/256:00 am -
1 stop20h 20m
Fri 1/229:55 pm -
1 stop15h 40m
Deal found 11/5$871
Wed 11/1812:20 pm -
2 stops24h 03m
Sun 12/610:30 pm -
1 stop18h 35m
Deal found 11/10$877
Thu 11/58:30 pm -
3 stops39h 18m
Sun 12/2710:30 pm -
1 stop18h 35m
Deal found 11/5$880
Wed 11/1812:20 pm -
2 stops24h 03m
Sun 12/610:30 pm -
2 stops19h 05m
Deal found 11/10$908
Wed 11/256:00 am -
1 stop20h 20m
Fri 1/229:55 pm -
2 stops19h 10m
Deal found 11/5$916
Thu 11/1912:20 pm -
1 stop31h 42m
Thu 11/263:29 pm -
2 stops33h 51m
Deal found 11/8$932

Find flight deals from Madrid to Panama City

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$702
(Avianca)

One-way from

$396
(Avianca)

Popular in

December

Cheapest in

April

Average price

$904

Good round-trip deal

$838 or less

Good one-way deal

$804 or less
Provider with most accurate pricing for Madrid Barajas-Panama City Tocumen Intl flight deals.
Provider most trusted by Cheapflights users for Madrid Barajas-Panama City Tocumen Intl flights.
From Madrid Barajas to Panama City Tocumen Intl
One-way flight from Madrid Barajas to Panama City Tocumen Intl
Highest demand for flights based on searches. 12% potential increase in price ($118 potential increase over avg. RT price).
Cheapest flight prices on average. 3% potential price decrease ($32 potential savings vs. average RT price).
Average for round-trip flights in November 2026
Price to beat on a round-trip flight from Madrid Barajas to Panama City Tocumen Intl.
Price to beat on a one-way flight from Madrid Barajas to Panama City Tocumen Intl.

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Madrid to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MadridPanama City

MAD Madrid Barajas - PTY Panama City Tocumen Intl

MADPTY

Madrid Barajas

Sun 2/14

7:05 am-1:20 am

2 stops24h 15m

Panama City Tocumen Intl

Wed 12/31

12:00 am-6:00 am

Nonstop0h 00m

$465

MadridPanama City

MAD Madrid Barajas - PTY Panama City Tocumen Intl

MADPTY

Madrid Barajas

Sat 1/23

8:00 pm-1:20 am

2 stops35h 20m

Panama City Tocumen Intl

Wed 12/31

12:00 am-6:00 am

Nonstop0h 00m

$478

MadridPanama City

MAD Madrid Barajas - PTY Panama City Tocumen Intl

MADPTY

Madrid Barajas

Tue 4/6

6:25 pm-9:15 am

2 stops21h 50m

Panama City Tocumen Intl

Wed 12/31

12:00 am-6:00 am

Nonstop0h 00m

$497

MadridPanama City

MAD Madrid Barajas - PTY Panama City Tocumen Intl

MADPTY

Madrid Barajas

Sun 1/24

7:05 am-9:10 am

2 stops32h 05m

Panama City Tocumen Intl

Wed 12/31

12:00 am-6:00 am

Nonstop0h 00m

$498

MadridPanama City

MAD Madrid Barajas - PTY Panama City Tocumen Intl

MADPTY

Madrid Barajas

Sun 4/4

7:05 pm-9:15 am

2 stops21h 10m

Panama City Tocumen Intl

Wed 12/31

12:00 am-6:00 am

Nonstop0h 00m

$499
Quickest round-trip

MadridPanama City

MAD Madrid Barajas - PTY Panama City Tocumen Intl

MADPTY

Madrid Barajas

Tue 2/2

3:10 pm-7:45 pm

Nonstop10h 35m

Panama City Tocumen Intl

Wed 12/31

12:00 am-6:00 am

Nonstop0h 00m

$637

MadridPanama City

MAD Madrid Barajas - PTY Panama City Tocumen Intl

MADPTY

Madrid Barajas

Tue 4/6

3:05 pm-6:40 pm

Nonstop10h 35m

Panama City Tocumen Intl

Wed 12/31

12:00 am-6:00 am

Nonstop0h 00m

$637

MadridPanama City

MAD Madrid Barajas - PTY Panama City Tocumen Intl

MADPTY

Madrid Barajas

Tue 4/6

12:00 pm-4:05 pm

Nonstop11h 05m

Panama City Tocumen Intl

Wed 12/31

12:00 am-6:00 am

Nonstop0h 00m

$648

MadridPanama City

MAD Madrid Barajas - PTY Panama City Tocumen Intl

MADPTY

Madrid Barajas

Thu 4/22

3:05 pm-6:40 pm

Nonstop10h 35m

Panama City Tocumen Intl

Wed 12/31

12:00 am-6:00 am

Nonstop0h 00m

$648

MadridPanama City

MAD Madrid Barajas - PTY Panama City Tocumen Intl

MADPTY

Madrid Barajas

Sat 1/16

5:00 pm-4:30 pm

1 stop29h 30m

Panama City Tocumen Intl

Wed 12/31

12:00 am-6:00 am

Nonstop0h 00m

$727

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Showing 1-10 of 18 resultsSorted by cheapest first
1
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Compare providers for flights from Madrid to Panama City

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Madrid to Panama City in November.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
BudgetAirPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Madrid-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Madrid-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Madrid-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Madrid-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Madrid-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Madrid to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Madrid with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Madrid to Panama City

How far ahead should I book a flight from Madrid to Panama City?

The price you pay for your flight from Madrid to Panama City may vary depending on when you book. For the best chance of a lower fare, look to book 83 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Madrid to Panama City?

Currently, April is the cheapest month in which you can book a flight from Madrid to Panama City (average of $725). Flying from Madrid to Panama City in December is currently the most expensive (average of $1,221). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MAD to PTY?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Madrid to Panama City as you normally would.

How much does it cost to fly round-trip from Madrid to Panama City?

Airfare is below average for this route at the moment.

Madrid to Panama City flights typically cost between $771 and $1,745 in January.
The cheapest round-trip price found within the last 5 days was $702 on Avianca (Jan 26-Feb 9).

The best insider tips for Madrid to Panama City flights

Cheapflights partnered with top experts to bring you the best recommendations for your Madrid to Panama City trip
Our travel experts
Lori Zaino

Lori Zaino

Expert on MAD

US-born but now based in Spain, Lori's visited 60 countries---and written about them for publications like CNN, Forbes, The Points Guy, NBC, and TripAdvisor. She loves combining affordable adventures with luxury travel experiences and feels equally at home salsa dancing in Colombia, sipping wine in a French castle, or backpacking through Malaysia.

Taryn White

Taryn White

Expert on PTY

Taryn White is a freelance travel writer, digital creator, and travel advisor who has visited nearly 100 countries and all 50 states. She’s familiar with many airports and enjoys beach hopping, boutique hotels, spa experiences, and exploring local culture. Her work has appeared in Travel + Leisure, Condé Nast Traveler, National Geographic, Smithsonian Magazine, AFAR, and more.

Reviews of airlines servicing Panama City

Get a feel of what it's like to fly with United Airlines,Air Europa, andIberia from Madrid to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Entertainment

7.1

Food

6.7

Comfort

7.3

Boarding

7.7

Overall

7.3

Crew

8.1

Reviews

1 / 20
4.0
Okay

Kevin,Dec 2025

BOS - EWR

Seems like every United flight has a delay and it’s always someone else’s fault. Step up and take some accountability

Entertainment

7.1

Food

6.7

Comfort

7.3

Boarding

7.7

Overall

7.3

Crew

8.1

Reviews

1 / 20
4.0
Okay

Kevin,Dec 2025

BOS - EWR

Seems like every United flight has a delay and it’s always someone else’s fault. Step up and take some accountability

Entertainment

7.1

Food

6.7

Comfort

7.3

Boarding

7.7

Overall

7.3

Crew

8.1

Reviews

1 / 20
4.0
Okay

Kevin,Dec 2025

BOS - EWR

Seems like every United flight has a delay and it’s always someone else’s fault. Step up and take some accountability

Entertainment

7.1

Food

6.7

Comfort

7.3

Boarding

7.7

Overall

7.3

Crew

8.1

Reviews

1 / 20
4.0
Okay

Kevin,Dec 2025

BOS - EWR

Seems like every United flight has a delay and it’s always someone else’s fault. Step up and take some accountability

Entertainment

7.1

Food

6.7

Comfort

7.3

Boarding

7.7

Overall

7.3

Crew

8.1

Reviews

1 / 20
4.0
Okay

Kevin,Dec 2025

BOS - EWR

Seems like every United flight has a delay and it’s always someone else’s fault. Step up and take some accountability

Related info for your journey

  • What airports do I use to fly from Madrid to Panama City?

    To fly from Madrid to Panama City, you need to book a flight from Barajas (MAD) to Tocumen Intl (PTY). Nonstop flights to Panama City Tocumen Intl from Madrid Barajas take 10h 35m on average. When it comes time to book airfare, you have a few options: there are 5 outbound flights from Barajas to Tocumen Intl offered by 4 different airlines.

  • How popular is this Madrid to Panama City flight route?

  • How long is the flight from Madrid to Panama City?

    Air Europa and United Airlines can get you from Madrid to Panama City in just under 10h 35m. Your travel time can differ by up to 33h 22m. Madrid and Panama City are separated by a distance of 5065 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Madrid to Panama City round-trip?

    Air Europa, at $642, was found to be the cheapest airline from Madrid to Panama City.Alternate airlines to your destination round-trip include United Airlines and Avianca. Air Europa is 26% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Madrid to Panama City one-way?

    For one-way options, check prices for Avianca. According to our data, you can fly for as low as $240. Users have also found prices from $341 and $371 on Air Europa and Iberia, respectively.

  • What are the most reliable airlines from Madrid to Panama City?

    Consider Air Europa (75%), Etihad Airways (75%) or China Eastern (75%) when booking your flight. These represent the most reliable airlines when flying from Madrid to Panama City.

  • What are the cheapest flights from Madrid to Panama City?

    The cheapest flight price from Madrid to Panama City is $672. On average you can expect to pay $1,740. The most popular route, (Madrid Barajas - Panama City Tocumen Intl), can usually be booked for $779.

  • Can I find deals for flights from Madrid to Panama City that include hotel bookings?

    Yes. In addition to deals on Madrid to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Madrid to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Panama City.

  • Can I find deals for business class flights from Madrid to Panama City?

    Yes. Cheapflights offers flight deals from Madrid to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Madrid to Panama City?

    Currently, April is the cheapest month in which you can book a flight from Madrid to Panama City (average of $725). Flying from Madrid to Panama City in December is currently the most expensive (average of $1,221). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 4 airlines flying from Madrid to Panama City

AirlineCheapestAverageFlexibilityOn-time
Air EuropaCheapest$642Average$847FlexibilityNo cancel feeOn-time83%
United AirlinesCheapest$644Average$1,196FlexibilityNo cancel feeOn-time69%
AviancaCheapest$732Average$1,322FlexibilityNo cancel feeOn-time71%
IberiaCheapest$757Average$1,150FlexibilityNo cancel feeOn-time77%

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