How popular is this Madrid to Panama City flight route?

The Madrid Barajas to Panama City Tocumen Intl flight path was viewed by 4 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

What are the cheapest airlines flying from Madrid to Panama City round-trip?

Avianca, at $582, was found to be the cheapest airline from Madrid to Panama City.Alternate airlines to your destination round-trip include Air Europa and Iberia. Avianca is 27% cheaper than the average price of flights available within the next 90 days to this destination.

What is the cheapest day to fly from Madrid to Panama City?

Travelers seeking maximum savings on their Madrid to Panama City flight should consider departing on Sunday afternoons when fares are most often at their lowest. Thursday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the cheapest flights from Madrid to Panama City?

The cheapest flight price from Madrid to Panama City is $586. On average you can expect to pay $1,032. The most popular route, (Madrid Barajas - Panama City Tocumen Intl), can usually be booked for $683.

What are the most reliable airlines from Madrid to Panama City?

Consider Hainan Airlines (86%), EL AL (81%) or Qatar Airways (79%) when booking your flight. These represent the most reliable airlines when flying from Madrid to Panama City.

What are the most popular airlines that fly from Madrid to Panama City?

The most popular airlines flying from Madrid to Panama City are Avianca, Iberia and Air Europa. Something to consider prior to booking your flight.

What is the cheapest day to fly round-trip from Madrid to Panama City?

Wednesday flights are found to be more expensive to fly from Madrid to Panama City. This shouldn’t discourage you from searching, as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to Panama City.

How far in advance should I book a flight from Madrid to Panama City?

To save on the cost of your flight from Madrid to Panama City, book at least 50 days before your planned departure. Booking around this time can save you about 28% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $713 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $902.

What is the cheapest month to fly from Madrid to Panama City?

Our data shows that March tends to be the cheapest month to fly to Panama City from Madrid. Users have commonly found prices around $805 for the month, but tickets can be as low as $541. Due to multiple factors, prepare for potentially higher prices in December.

What airports do I use to fly from Madrid to Panama City?

To fly from Madrid to Panama City, you need to book a flight from Barajas (MAD) to Tocumen Intl (PTY). Nonstop flights to Panama City Tocumen Intl from Madrid Barajas take 10h 35m on average. When it comes time to book airfare, you have a few options: there are 7 outbound flights from Barajas to Tocumen Intl offered by 3 different airlines.

Can I find deals for flights from Madrid to Panama City that include hotel bookings?

Yes. In addition to deals on Madrid to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Madrid to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Panama City.

Can I find deals for business class flights from Madrid to Panama City?

Yes. Cheapflights offers flight deals from Madrid to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$345+ Flights from Madrid, Spain to Panama City

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

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Cheapflights Tip: The best prices from Madrid Barajas to Panama City Tocumen Intl are usually found in March or February, booked 79 days in advance, depart on a Wednesday or Sunday and return on a Tuesday

Cheap flight deals from Madrid to Panama City

Round-trip from	$683 (United Airlines)
One-way from	$345 (Air Europa)
Popular in	December
Cheapest in	March
Average price	$1,009
Good round-trip deal	$884 or less
Good one-way deal	$804 or less

From Madrid Barajas to Panama City Tocumen Intl

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One-way flight from Madrid Barajas to Panama City Tocumen Intl

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Highest demand for flights based on searches. 9% potential increase in price ($85 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($30 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in August 2025

Search Deals

Price to beat on a round-trip flight from Madrid Barajas to Panama City Tocumen Intl.

Search Deals

Price to beat on a one-way flight from Madrid Barajas to Panama City Tocumen Intl.

Search Deals

Find flight deals from Madrid to Panama City

Cheapest flights from Madrid to Panama City
Explore the most affordable flight options available from Madrid to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Fri 11/1411:15 amMAD - PTY

2 stops33h 30mUnited Airlines

Thu 12/411:35 amPTY - MAD

2 stops39h 40mUnited Airlines

Deal found 8/14

$685

Fri 11/1411:05 amMAD - PTY

2 stops33h 40mUnited Airlines

Sat 2/148:55 amPTY - MAD

2 stops25h 05mUnited Airlines

Deal found 8/13

$690

Thu 10/911:15 amMAD - PTY

2 stops33h 35mUnited Airlines

Thu 10/239:45 amPTY - MAD

2 stops19h 05mUnited Airlines

Deal found 8/13

$692

Sun 11/163:10 pmMAD - PTY

Nonstop10h 35mAir Europa

Sat 11/299:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Deal found 8/14

$694

Wed 9/1011:15 amMAD - PTY

2 stops33h 59mUnited Airlines

Tue 11/1810:00 amPTY - MAD

2 stops19h 45mUnited Airlines

Deal found 8/14

$695

Sun 10/123:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Sat 10/259:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Deal found 8/13

$711

Thu 11/133:10 pmMAD - PTY

Nonstop10h 35mAir Europa

Tue 11/259:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Deal found 8/13

$712

Sun 10/123:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Tue 11/49:30 pmPTY - MAD

Nonstop9h 35mAir Europa

Deal found 8/14

$715

Thu 11/131:20 amMAD - PTY

1 stop42h 40mAvianca

Fri 2/132:55 amPTY - MAD

1 stop38h 25mAvianca

Deal found 8/13

$717

Thu 9/2511:15 amMAD - PTY

2 stops38h 22mUnited Airlines

Thu 10/99:45 amPTY - MAD

2 stops27h 05mUnited Airlines

Deal found 8/14

$718

Sat 9/136:00 amMAD - PTY

1 stop17h 50mMultiple Airlines

Sat 11/293:17 pmPTY - MAD

1 stop35h 43mMultiple Airlines

Deal found 8/14

$721

Thu 8/2811:15 amMAD - PTY

2 stops33h 59mUnited Airlines

Wed 9/179:45 amPTY - MAD

2 stops24h 00mUnited Airlines

Deal found 8/14

$724

Best flights from Madrid to Panama City
Discover carefully curated flight deals from Madrid to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2025.

Mon 2/911:15 amMAD - PTY

2 stops33h 30mUnited Airlines

Wed 2/184:40 pmPTY - MAD

2 stops34h 35mUnited Airlines

Deal found 8/14

$683

Fri 11/1411:15 amMAD - PTY

2 stops33h 30mUnited Airlines

Thu 12/44:41 pmPTY - MAD

2 stops34h 34mUnited Airlines

Deal found 8/14

$685

Sun 11/1611:05 amMAD - PTY

2 stops38h 33mUnited Airlines

Sat 11/2910:00 amPTY - MAD

2 stops40h 05mUnited Airlines

Deal found 8/14

$685

Wed 9/1010:50 amMAD - PTY

2 stops34h 24mUnited Airlines

Fri 9/193:30 pmPTY - MAD

2 stops33h 35mUnited Airlines

Deal found 8/14

$685

Thu 9/2511:15 amMAD - PTY

2 stops38h 22mUnited Airlines

Sun 10/129:45 amPTY - MAD

1 stop16h 15mUnited Airlines

Deal found 8/14

$685

Fri 11/1411:15 amMAD - PTY

2 stops33h 30mUnited Airlines

Wed 12/311:35 amPTY - MAD

2 stops38h 30mUnited Airlines

Deal found 8/14

$685

Fri 11/1411:05 amMAD - PTY

2 stops32h 50mUnited Airlines

Fri 12/511:35 amPTY - MAD

2 stops38h 30mUnited Airlines

Deal found 8/14

$685

Fri 10/311:15 amMAD - PTY

2 stops33h 35mUnited Airlines

Mon 10/139:45 amPTY - MAD

1 stop16h 15mUnited Airlines

Deal found 8/14

$685

Fri 10/1011:15 amMAD - PTY

2 stops38h 22mUnited Airlines

Sun 10/199:45 amPTY - MAD

1 stop16h 15mUnited Airlines

Deal found 8/14

$685

Thu 10/911:15 amMAD - PTY

2 stops38h 22mUnited Airlines

Mon 10/2010:00 amPTY - MAD

2 stops40h 00mUnited Airlines

Deal found 8/14

$685

Last-minute flights from Madrid to Panama City
Discover last-minute flight deals from Madrid to Panama City. Data last updated August 14, 2025 and is based on user searches.

Tue 8/196:00 amMAD - PTY

1 stop18h 45mMultiple Airlines

Fri 8/226:50 pmPTY - MAD

1 stop31h 45mMultiple Airlines

Deal found 8/13

$1,018

Tue 8/198:25 pmMAD - PTY

1 stop27h 25mMultiple Airlines

Sun 8/317:55 pmPTY - MAD

1 stop13h 50mMultiple Airlines

Deal found 8/13

$1,127

Wed 8/2010:50 amMAD - PTY

1 stop15h 41mUnited Airlines

Tue 9/29:45 amPTY - MAD

2 stops24h 00mUnited Airlines

Deal found 8/13

$1,053

Wed 8/208:25 pmMAD - PTY

1 stop27h 25mMultiple Airlines

Sat 8/307:55 pmPTY - MAD

1 stop30h 15mMultiple Airlines

Deal found 8/13

$1,112

Thu 8/2110:05 amMAD - PTY

1 stop33h 45mDelta

Sat 8/302:05 pmPTY - MAD

2 stops36h 30mDelta

Deal found 8/13

$1,078

Thu 8/216:00 amMAD - PTY

1 stop17h 50mMultiple Airlines

Sun 8/317:55 pmPTY - MAD

1 stop13h 50mMultiple Airlines

Deal found 8/13

$1,083

Thu 8/211:05 pmMAD - PTY

2 stops31h 28mUnited Airlines

Sun 8/3110:29 pmPTY - MAD

2 stops35h 16mUnited Airlines

Deal found 8/13

$1,148

Fri 8/2211:15 amMAD - PTY

2 stops33h 59mUnited Airlines

Thu 9/189:45 amPTY - MAD

2 stops19h 30mUnited Airlines

Deal found 8/14

$1,094

Fri 8/226:00 amMAD - PTY

2 stops37h 50mDelta

Sat 8/302:05 pmPTY - MAD

2 stops36h 30mDelta

Deal found 8/13

$1,122

Sat 8/2310:05 amMAD - PTY

1 stop33h 45mDelta

Sat 8/302:05 pmPTY - MAD

2 stops36h 30mDelta

Deal found 8/14

$1,084

Thu 8/2811:15 amMAD - PTY

2 stops33h 59mUnited Airlines

Wed 9/179:45 amPTY - MAD

2 stops24h 00mUnited Airlines

Deal found 8/14

$724

Thu 8/2810:50 amMAD - PTY

1 stop15h 41mUnited Airlines

Thu 9/49:45 amPTY - MAD

2 stops24h 00mUnited Airlines

Deal found 8/14

$765

One-way flights from Madrid to Panama City
Search for one-way flight options from Madrid to Panama City. Find affordable one-way fares based on user searches. Data last updated August 14, 2025.

Tue 9/93:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Deal found 8/14

$345

Thu 9/41:30 amMAD - PTY

1 stop30h 15mAvianca

Deal found 8/13

$414

Fri 10/171:30 amMAD - PTY

1 stop14h 25mAvianca

Deal found 8/13

$431

Wed 10/151:30 amMAD - PTY

1 stop14h 25mAvianca

Deal found 8/13

$451

Thu 9/115:30 pmMAD - PTY

2 stops26h 05mAvianca

Deal found 8/12

$452

Mon 10/208:15 pmMAD - PTY

2 stops54h 45mMultiple Airlines

Deal found 8/13

$481

Fri 10/37:40 amMAD - PTY

3 stops24h 05mMultiple Airlines

Deal found 8/14

$513

Thu 10/21:30 amMAD - PTY

1 stop22h 00mAvianca

Deal found 8/14

$540

Fri 1/210:50 amMAD - PTY

1 stop19h 50mAvianca

Deal found 8/13

$541

Fly from

Fly to

Route

Depart

Return

Price

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Mon 2/9

11:15 am-2:45 pm

2 stops33h 30m

Panama City Tocumen Intl

Wed 2/18

4:40 pm-9:15 am

2 stops34h 35m

$683

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Fri 11/14

11:15 am-2:45 pm

2 stops33h 30m

Panama City Tocumen Intl

Thu 12/4

4:41 pm-9:15 am

2 stops34h 34m

$685

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sun 11/16

11:05 am-7:38 pm

2 stops38h 33m

Panama City Tocumen Intl

Sat 11/29

10:00 am-8:05 am

2 stops40h 05m

$685

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Wed 9/10

10:50 am-2:14 pm

2 stops34h 24m

Panama City Tocumen Intl

Fri 9/19

3:30 pm-8:05 am

2 stops33h 35m

$685

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 9/25

11:15 am-6:37 pm

2 stops38h 22m

Panama City Tocumen Intl

Sun 10/12

9:45 am-9:00 am

1 stop16h 15m

$685

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Fri 11/14

11:15 am-2:45 pm

2 stops33h 30m

Panama City Tocumen Intl

Wed 12/3

11:35 am-8:05 am

2 stops38h 30m

$685

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Fri 11/14

11:05 am-1:55 pm

2 stops32h 50m

Panama City Tocumen Intl

Fri 12/5

11:35 am-8:05 am

2 stops38h 30m

$685

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Fri 10/3

11:15 am-1:50 pm

2 stops33h 35m

Panama City Tocumen Intl

Mon 10/13

9:45 am-9:00 am

1 stop16h 15m

$685

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Fri 10/10

11:15 am-6:37 pm

2 stops38h 22m

Panama City Tocumen Intl

Sun 10/19

9:45 am-9:00 am

1 stop16h 15m

$685

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 10/9

11:15 am-6:37 pm

2 stops38h 22m

Panama City Tocumen Intl

Mon 10/20

10:00 am-9:00 am

2 stops40h 00m

$685

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 19 results

The best insider tips for Madrid to Panama City flights

Cheapflights partnered with top experts to bring you the best recommendations for your Madrid to Panama City trip

Airports

MAD

Many airlines at MAD offer automated kiosks for quick check-in, including Iberia. Security lines can be crowded but move quickly.

PTY

At PTY, Uber is often the fastest and less expensive transport option to Panama City, compared to taxis.

Our travel experts

Lori Zaino

Expert on MAD

Taryn White

Expert on PTY

Best time to book a flight from Madrid to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Madrid with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Madrid to Panama City

How far ahead should I book a flight from Madrid to Panama City?

The price you pay for your flight from Madrid to Panama City may vary depending on when you book. For the best chance of a lower fare, look to book 79 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Madrid to Panama City?

Currently, October is the cheapest month in which you can book a flight from Madrid to Panama City (average of $478). Flying from Madrid to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MAD to PTY?

It’s optimal to fly from Madrid to Panama City in the morning. By choosing this option you can save up to 4% on the cost of your flight, compared to a flight at noon.

Weekly flight availability from Madrid to Panama City

The most flights from MAD to PTY are scheduled on a Thursday (10 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (5 on average).

Reviews of airlines servicing Panama City

Get a feel of what it's like to fly with Air Europa, Iberia, and Avianca from Madrid to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Air Europa

7.0

Good

545 reviews

Reviews

1 / 10

8.0

Excellent

Christina,Jun 2025

ALC - MAD

It would be nice to have free messaging wifi on a trans Atlantic flight

Air Europa

7.0

Good

545 reviews

Air Europa

7.0

Good

545 reviews

Reviews

1 / 10

8.0

Excellent

Christina,Jun 2025

ALC - MAD

It would be nice to have free messaging wifi on a trans Atlantic flight

Iberia

7.0

Good

2,882 reviews

Air Europa

7.0

Good

545 reviews

Reviews

1 / 10

8.0

Excellent

Christina,Jun 2025

ALC - MAD

It would be nice to have free messaging wifi on a trans Atlantic flight

Avianca

6.7

Okay

2,401 reviews

Air Europa

7.0

Good

545 reviews

Reviews

1 / 10

8.0

Excellent

Christina,Jun 2025

ALC - MAD

It would be nice to have free messaging wifi on a trans Atlantic flight

Related info for your journey

What airports do I use to fly from Madrid to Panama City?
To fly from Madrid to Panama City, you need to book a flight from Barajas (MAD) to Tocumen Intl (PTY). Nonstop flights to Panama City Tocumen Intl from Madrid Barajas take 10h 35m on average. When it comes time to book airfare, you have a few options: there are 7 outbound flights from Barajas to Tocumen Intl offered by 3 different airlines.
How popular is this Madrid to Panama City flight route?
The Madrid Barajas to Panama City Tocumen Intl flight path was viewed by 4 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
What are the cheapest airlines flying from Madrid to Panama City round-trip?
Avianca, at $582, was found to be the cheapest airline from Madrid to Panama City.Alternate airlines to your destination round-trip include Air Europa and Iberia. Avianca is 27% cheaper than the average price of flights available within the next 90 days to this destination.
What are the most reliable airlines from Madrid to Panama City?
Consider Hainan Airlines (86%), EL AL (81%) or Qatar Airways (79%) when booking your flight. These represent the most reliable airlines when flying from Madrid to Panama City.
What are the cheapest flights from Madrid to Panama City?
The cheapest flight price from Madrid to Panama City is $586. On average you can expect to pay $1,032. The most popular route, (Madrid Barajas - Panama City Tocumen Intl), can usually be booked for $683.
Can I find deals for flights from Madrid to Panama City that include hotel bookings?
Yes. In addition to deals on Madrid to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Madrid to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Panama City.
Can I find deals for business class flights from Madrid to Panama City?
Yes. Cheapflights offers flight deals from Madrid to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Madrid to Panama City?
Currently, October is the cheapest month in which you can book a flight from Madrid to Panama City (average of $478). Flying from Madrid to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Complete your trip

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Top 3 airlines flying from Madrid to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$582	Average$1,069	FlexibilityNo cancel fee	On-time71%
Air Europa	Cheapest$623	Average$866	FlexibilityNo cancel fee	On-time83%
Iberia	Cheapest$644	Average$793	FlexibilityNo cancel fee	On-time77%

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$345+ Cheap flights from Madrid, Spain (MAD) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/9. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Madrid to Panama City with Cheapflights

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Cheapflights Tip: The best prices from Madrid Barajas to Panama City Tocumen Intl are usually found in March or February, booked 79 days in advance, depart on a Wednesday or Sunday and return on a Tuesday

Cheap flight deals from Madrid to Panama City

Round-trip from

One-way from

Popular in

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Good one-way deal

Find flight deals from Madrid to Panama City

Cheapest flights from Madrid to Panama CityExplore the most affordable flight options available from Madrid to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Explore the most affordable flight options available from Madrid to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Madrid to Panama City that are best for you.

The best insider tips for Madrid to Panama City flights

Cheapflights partnered with top experts to bring you the best recommendations for your Madrid to Panama City trip

Airports

MAD

PTY

Our travel experts

Best time to book a flight from Madrid to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Madrid with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Madrid to Panama City

How far ahead should I book a flight from Madrid to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Madrid to Panama City. Price data was last updated on August 8, 2025.

What is the cheapest month to book a flight from Madrid to Panama City?

What is the cheapest time of day to fly from MAD to PTY?

Find hourly flight availability from Madrid to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

Weekly flight availability from Madrid to Panama City

Explore weekly flight availability from Madrid to Panama City. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 14, 2025.

Reviews of airlines servicing Panama City

Get a feel of what it's like to fly with Air Europa, Iberia, and Avianca from Madrid to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Madrid to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Madrid to Panama City?

How popular is this Madrid to Panama City flight route?

What are the cheapest airlines flying from Madrid to Panama City round-trip?

What are the most reliable airlines from Madrid to Panama City?

What are the cheapest flights from Madrid to Panama City?

Can I find deals for flights from Madrid to Panama City that include hotel bookings?

How can I find direct flights from Madrid to Panama City?

Can I find deals for business class flights from Madrid to Panama City?

What is the cheapest month to book a flight from Madrid to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.

Top 3 airlines flying from Madrid to Panama City

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Cheapest flights from Madrid to Panama City
Explore the most affordable flight options available from Madrid to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.