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Panama City

$174+ Cheap flights from Greenville (GSP) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/24. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Greenville to Panama City

Cheapest flights from Greenville to Panama City
Explore the most affordable flight options available from Greenville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:53 pm
GSP
-
PTY
2 stops18h 47m
American Airlines
Wed 3/181:40 pm
PTY
-
GSP
2 stops19h 35m
American Airlines
Deal found 1/24$417
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/107:00 am
GSP
-
PTY
1 stop12h 37m
United Airlines
Wed 8/123:20 pm
PTY
-
GSP
1 stop22h 58m
United Airlines
Deal found 1/26$421
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/236:53 pm
GSP
-
PTY
2 stops18h 47m
American Airlines
Mon 3/24:05 pm
PTY
-
GSP
2 stops18h 54m
American Airlines
Deal found 1/25$435
This Ovago deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:15 am
GSP
-
PTY
1 stop13h 47m
Multiple Airlines
Wed 3/259:30 am
PTY
-
GSP
1 stop13h 29m
Multiple Airlines
Deal found 1/25$469
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/234:36 pm
GSP
-
PTY
1 stop27h 02m
United Airlines
Mon 3/24:41 pm
PTY
-
GSP
1 stop22h 55m
United Airlines
Deal found 1/26$489
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/128:17 pm
GSP
-
PTY
2 stops19h 03m
American Airlines
Thu 3/191:40 pm
PTY
-
GSP
2 stops20h 04m
American Airlines
Deal found 1/26$495
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/74:26 pm
GSP
-
PTY
2 stops20h 14m
American Airlines
Mon 3/161:40 pm
PTY
-
GSP
2 stops21h 34m
American Airlines
Deal found 1/25$513

Find flight deals from Greenville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$417
(American Airlines)

One-way from

$174
(United Airlines)

Popular in

December

Cheapest in

August

Average price

$615
Provider with most accurate pricing for Greenville-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Panama City Tocumen Intl flights.
Search Deals
From Greenville to Panama City Tocumen Intl
Search Deals
One-way flight from Greenville to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 35% potential increase in price ($296 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 16% potential price decrease ($78 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Greenville to Panama City that are best for you.

Fly from

Greenville

Fly to

Panama City

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 3/11

6:53 pm-12:40 pm

2 stops18h 47m

Panama City Tocumen Intl

Wed 3/18

1:40 pm-10:15 am

2 stops19h 35m

$417

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 3/11

7:37 pm-2:20 pm

2 stops19h 43m

Panama City Tocumen Intl

Wed 3/25

1:40 pm-10:15 am

2 stops19h 35m

$417

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 2/23

6:53 pm-1:40 pm

2 stops18h 47m

Panama City Tocumen Intl

Mon 3/2

4:05 pm-10:42 am

2 stops18h 37m

$435

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 3/11

6:15 am-7:02 pm

1 stop13h 47m

Panama City Tocumen Intl

Wed 3/25

9:30 am-11:59 pm

1 stop13h 29m

$469

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 2/23

4:36 pm-7:38 pm

1 stop27h 02m

Panama City Tocumen Intl

Mon 3/2

4:41 pm-3:36 pm

1 stop22h 55m

$489

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 3/12

8:17 pm-2:20 pm

2 stops19h 03m

Panama City Tocumen Intl

Thu 3/19

3:10 pm-12:21 am

1 stop8h 11m

$495

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 2/24

6:50 am-2:45 pm

1 stop7h 55m

$174

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 2/24

5:20 am-1:40 pm

2 stops8h 20m

$289

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Compare providers for flights from Greenville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Panama City in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Panama City

What is the cheapest month to book a flight from Greenville to Panama City?

Currently, August is the cheapest month in which you can book a flight from Greenville to Panama City (average of $267). Flying from Greenville to Panama City in December is currently the most expensive (average of $520). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated January 27, 2026.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Greenville to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,119 reviews

Food

7.2

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,119 reviews
Delta
7.9
Good
8,119 reviews

Food

7.2

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,205 reviews
Delta
7.9
Good
8,119 reviews

Food

7.2

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,197 reviews
Delta
7.9
Good
8,119 reviews

Food

7.2

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Panama City?

    American Airlines can get you from Greenville to Panama City in just under 18h 47m. Your travel time can differ by up to . Greenville and Panama City are separated by a distance of 1792 mi.

  • What are the cheapest airlines flying from Greenville to Panama City round-trip?

    Flying on American Airlines is currently your cheapest option to Panama City, with prices starting at $353. Additional round-trip tickets that might be worth considering are offered by Delta and United Airlines, with the lowest prices starting at $371 and $383, respectively. American Airlines is priced at 34% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Greenville to Panama City that include hotel bookings?

    Yes. In addition to deals on Greenville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Panama City.

  • Can I find deals for business class flights from Greenville to Panama City?

    Yes. Cheapflights offers flight deals from Greenville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Panama City?

    Currently, August is the cheapest month in which you can book a flight from Greenville to Panama City (average of $267). Flying from Greenville to Panama City in December is currently the most expensive (average of $520). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Greenville to Panama City

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Top 3 airlines flying from Greenville to Panama City

Discover the top 3 airlines that operate flights from Greenville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$353Average$613FlexibilityNo cancel feeOn-time71%
DeltaCheapest$371Average$435FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$383Average$401FlexibilityNo cancel feeOn-time69%

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