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Panama City

$195+ Cheap flights from Greenville (GSP) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/21. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
Apr 11 — Apr 181
Sat 4/11
Sat 4/18
1 adult, Economy
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Cheap flight deals from Greenville to Panama City

Cheapest flights from Greenville to Panama City
Explore the most affordable flight options available from Greenville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.

This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:00 am
GSP
-
PTY
1 stop12h 37m
United Airlines
Tue 4/287:55 am
PTY
-
GSP
1 stop13h 04m
United Airlines
Deal found 3/7$463
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:40 am
GSP
-
PTY
1 stop8h 23m
Delta
Thu 4/162:27 pm
PTY
-
GSP
1 stop8h 29m
Delta
Deal found 3/7$469
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/712:07 pm
GSP
-
PTY
1 stop8h 24m
United Airlines
Tue 4/143:30 pm
PTY
-
GSP
1 stop29h 29m
United Airlines
Deal found 3/7$472
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:29 pm
GSP
-
PTY
2 stops22h 32m
American Airlines
Thu 4/161:49 pm
PTY
-
GSP
1 stop9h 10m
American Airlines
Deal found 3/7$473
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/308:17 pm
GSP
-
PTY
2 stops19h 44m
American Airlines
Thu 4/21:40 pm
PTY
-
GSP
2 stops17h 58m
American Airlines
Deal found 3/8$479
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:42 am
GSP
-
PTY
1 stop8h 20m
Delta
Thu 5/142:15 pm
PTY
-
GSP
1 stop8h 28m
Delta
Deal found 3/10$483
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/155:55 am
GSP
-
PTY
1 stop9h 15m
American Airlines
Thu 10/153:35 pm
PTY
-
GSP
2 stops21h 32m
American Airlines
Deal found 3/11$487
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:23 pm
GSP
-
PTY
1 stop20h 39m
Delta
Wed 5/132:15 pm
PTY
-
GSP
1 stop8h 28m
Delta
Deal found 3/10$489
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:00 am
GSP
-
PTY
1 stop8h 14m
United Airlines
Mon 5/113:30 pm
PTY
-
GSP
1 stop29h 44m
United Airlines
Deal found 3/10$492
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/176:40 am
GSP
-
PTY
1 stop7h 00m
American Airlines
Thu 3/193:10 pm
PTY
-
GSP
1 stop8h 11m
American Airlines
Deal found 3/11$495
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:36 am
GSP
-
PTY
2 stops13h 55m
United Airlines
Thu 5/143:30 pm
PTY
-
GSP
1 stop29h 44m
United Airlines
Deal found 3/10$497

Find flight deals from Greenville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$463
(United Airlines)

One-way from

$195
(United Airlines)

Popular in

December

Cheapest in

August

Average price

$574
Provider with most accurate pricing for Greenville-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Panama City Tocumen Intl flights.
Search Deals
From Greenville to Panama City Tocumen Intl
Search Deals
One-way flight from Greenville to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 33% potential increase in price ($280 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 17% potential price decrease ($83 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
Use the filters below to find and compare flights from Greenville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 4/21

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Tue 4/28

7:55 am-9:59 pm

1 stop13h 04m

$463

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 3/31

5:40 am-1:03 pm

1 stop8h 23m

Panama City Tocumen Intl

Thu 4/16

2:27 pm-11:56 pm

1 stop8h 29m

$469
Quickest round-trip

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 5/5

5:42 am-1:02 pm

1 stop8h 20m

Panama City Tocumen Intl

Thu 5/14

2:15 pm-11:43 pm

1 stop8h 28m

$483

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 3/26

6:52 am-6:38 pm

1 stop12h 46m

Panama City Tocumen Intl

Wed 4/1

3:30 pm-11:54 am

2 stops19h 24m

$499

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 5/6

6:36 am-7:31 pm

2 stops13h 55m

Panama City Tocumen Intl

Fri 5/8

10:55 pm-4:57 pm

2 stops17h 02m

$505

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 5/9

6:36 am-7:31 pm

2 stops13h 55m

Panama City Tocumen Intl

Wed 5/13

10:00 am-9:58 am

2 stops22h 58m

$505

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 5/27

7:00 am-4:12 pm

1 stop10h 12m

Panama City Tocumen Intl

Fri 6/5

7:55 am-10:11 am

2 stops25h 16m

$505

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 4/7

11:54 am-12:46 pm

2 stops25h 52m

Panama City Tocumen Intl

Tue 4/14

1:49 pm-12:05 pm

2 stops21h 16m

$510

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 4/30

7:35 pm-2:14 pm

2 stops19h 39m

Panama City Tocumen Intl

Sat 5/9

3:30 pm-9:47 am

2 stops17h 17m

$523

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 4/25

7:42 pm-4:12 pm

2 stops21h 30m

Panama City Tocumen Intl

Sat 5/2

3:30 pm-9:47 am

2 stops17h 17m

$523

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/7

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

Compare providers for flights from Greenville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Panama City in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Panama City

What is the cheapest month to book a flight from Greenville to Panama City?

Currently, August is the cheapest month in which you can book a flight from Greenville to Panama City (average of $267). Flying from Greenville to Panama City in December is currently the most expensive (average of $516). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated March 12, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Greenville to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,286 reviews

Food

7.2

Boarding

8.1

Entertainment

7.8

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,286 reviews
Delta
7.9
Good
8,286 reviews

Food

7.2

Boarding

8.1

Entertainment

7.8

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,418 reviews
Delta
7.9
Good
8,286 reviews

Food

7.2

Boarding

8.1

Entertainment

7.8

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,435 reviews
Delta
7.9
Good
8,286 reviews

Food

7.2

Boarding

8.1

Entertainment

7.8

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Panama City?

    United Airlines and Delta can get you from Greenville to Panama City in just under 8h 23m. Your travel time can differ by up to 4h 14m. Greenville and Panama City are separated by a distance of 1792 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Greenville to Panama City round-trip?

    Flying on American Airlines is currently your cheapest option to Panama City, with prices starting at $353. Additional round-trip tickets that might be worth considering are offered by Delta and United Airlines, with the lowest prices starting at $371 and $391, respectively. American Airlines is priced at 36% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Greenville to Panama City that include hotel bookings?

    Yes. In addition to deals on Greenville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Panama City.

  • Can I find deals for business class flights from Greenville to Panama City?

    Yes. Cheapflights offers flight deals from Greenville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Panama City?

    Currently, August is the cheapest month in which you can book a flight from Greenville to Panama City (average of $267). Flying from Greenville to Panama City in December is currently the most expensive (average of $516). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Greenville to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Greenville to Panama City

Discover the top 3 airlines that operate flights from Greenville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$353Average$629FlexibilityNo cancel feeOn-time71%
DeltaCheapest$371Average$452FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$391Average$419FlexibilityNo cancel feeOn-time69%

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