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Panama City

$231+ Cheap flights from Greenville (GSP) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/13. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
Jan 13 — Jan 201
Tue 1/13
Tue 1/20
1 adult, Economy
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Cheap flight deals from Greenville to Panama City

Cheapest flights from Greenville to Panama City
Explore the most affordable flight options available from Greenville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 14, 2025.

This American Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:15 pmGSP - PTY
2 stops19h 32mAmerican Airlines
Fri 12/194:55 pmPTY - GSP
2 stops15h 41mAmerican Airlines
Deal found 12/12$478
This American Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:20 pmGSP - PTY
2 stops19h 33mAmerican Airlines
Tue 1/62:27 pmPTY - GSP
2 stops20h 03mAmerican Airlines
Deal found 12/12$727
This United Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:44 pmGSP - PTY
1 stop25h 54mUnited Airlines
Tue 1/64:41 pmPTY - GSP
1 stop29h 16mUnited Airlines
Deal found 12/14$792
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:04 pmGSP - PTY
1 stop19h 50mAmerican Airlines
Fri 1/22:53 pmPTY - GSP
1 stop9h 58mAmerican Airlines
Deal found 12/14$1,159

Find flight deals from Greenville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 14, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$392
(United Airlines)

One-way from

$231
(United Airlines)

Popular in

December

Cheapest in

August

Average price

$1,387
Provider with most accurate pricing for Greenville-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Greenville-Panama City Tocumen Intl flights.
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From Greenville to Panama City Tocumen Intl
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One-way flight from Greenville to Panama City Tocumen Intl
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Highest demand for flights based on searches. 33% potential increase in price ($272 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 16% potential price decrease ($77 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 14, 2025.
Use the filters below to find and compare flights from Greenville to Panama City that are best for you.

Fly from

Greenville

Fly to

Panama City

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

7:00 pm-3:38 pm

2 stops20h 38m

Panama City Tocumen Intl

Wed 2/4

2:27 pm-11:57 pm

1 stop9h 30m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 1/5

6:45 am-7:38 pm

1 stop12h 53m

Panama City Tocumen Intl

Thu 1/15

4:41 pm-9:57 pm

1 stop29h 16m

$406

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 1/19

4:50 pm-5:07 pm

1 stop24h 17m

Panama City Tocumen Intl

Thu 1/22

4:41 pm-9:57 pm

1 stop29h 16m

$408

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/7

4:50 pm-5:07 pm

1 stop24h 17m

Panama City Tocumen Intl

Thu 1/15

4:41 pm-9:57 pm

1 stop29h 16m

$414

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 1/5

6:45 am-5:07 pm

1 stop10h 22m

Panama City Tocumen Intl

Tue 1/13

4:41 pm-3:35 pm

1 stop22h 54m

$432

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 1/8

6:49 am-2:45 pm

1 stop7h 56m

Panama City Tocumen Intl

Tue 1/13

4:41 pm-9:57 pm

1 stop29h 16m

$432

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/7

4:50 pm-2:45 pm

1 stop21h 55m

Panama City Tocumen Intl

Fri 1/16

4:41 pm-3:35 pm

1 stop22h 54m

$433

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sun 1/11

5:40 pm-3:38 pm

2 stops21h 58m

Panama City Tocumen Intl

Sun 1/18

2:27 pm-12:07 pm

2 stops21h 40m

$437

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/7

4:50 pm-2:45 pm

1 stop21h 55m

Panama City Tocumen Intl

Tue 1/13

4:41 pm-9:57 pm

1 stop29h 16m

$440

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 1/10

6:49 am-7:38 pm

1 stop12h 49m

Panama City Tocumen Intl

Tue 1/13

4:41 pm-3:35 pm

1 stop22h 54m

$444

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/12

Showing 1-10 of 15 results
1
2

Compare providers for flights from Greenville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Panama City in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Greenville-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Greenville-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Panama City

What is the cheapest month to book a flight from Greenville to Panama City?

Currently, August is the cheapest month in which you can book a flight from Greenville to Panama City (average of $267). Flying from Greenville to Panama City in January is currently the most expensive (average of $435). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to PTY?

Find hourly flight availability from Greenville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 14, 2025.

When flying from Greenville to Panama City, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 58% versus a flight at noon.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated December 14, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Greenville to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Crew

8.5

Overall

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Crew

8.5

Overall

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,094 reviews
Delta
7.9
Good
8,007 reviews

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Crew

8.5

Overall

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,007 reviews

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Crew

8.5

Overall

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Panama City?

    American Airlines and United Airlines can get you from Greenville to Panama City in just under 12h 53m. Your travel time can differ by up to 7h 45m. Greenville and Panama City are separated by a distance of 1792 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Greenville to Panama City round-trip?

    Flying on Delta is currently your cheapest option to Panama City, with prices starting at $371. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $383 and $383, respectively. Delta is priced at 32% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Greenville to Panama City that include hotel bookings?

    Yes. In addition to deals on Greenville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Panama City.

  • Can I find deals for business class flights from Greenville to Panama City?

    Yes. Cheapflights offers flight deals from Greenville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Panama City?

    Currently, August is the cheapest month in which you can book a flight from Greenville to Panama City (average of $267). Flying from Greenville to Panama City in January is currently the most expensive (average of $435). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Greenville to Panama City

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Top 3 airlines flying from Greenville to Panama City

Discover the top 3 airlines that operate flights from Greenville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$353Average$583FlexibilityNo cancel feeOn-time71%
DeltaCheapest$371Average$435FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$383Average$419FlexibilityNo cancel feeOn-time69%

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