HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$169+ Cheap flights from Greenville (GSP) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/17. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Greenville to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Greenville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$391
(United Airlines)

One-way from

$169
(United Airlines)

Popular in

March

Cheapest in

November

Average price

$471
From Greenville to Panama City Tocumen Intl
Search Deals
One-way flight from Greenville to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($42 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2025
Search Deals

Find flight deals from Greenville to Panama City

Cheapest flights from Greenville to Panama City
Explore the most affordable flight options available from Greenville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/286:45 amGSP - PTY
1 stop12h 53mUnited Airlines
Wed 11/58:55 amPTY - GSP
1 stop13h 04mUnited Airlines
Deal found 6/12$391
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/136:44 pmGSP - PTY
2 stops20h 46mAmerican Airlines
Tue 8/193:30 pmPTY - GSP
2 stops19h 11mAmerican Airlines
Deal found 6/12$396
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/127:59 pmGSP - PTY
1 stop24h 31mDelta
Fri 6/202:23 pmPTY - GSP
1 stop8h 34mDelta
Deal found 6/12$450
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/84:05 pmGSP - PTY
2 stops33h 05mMultiple Airlines
Sun 8/108:10 pmPTY - GSP
3 stops18h 05mMultiple Airlines
Deal found 6/10$575

Cheapflights Fare Finder

Customize your flight search to find flights from Greenville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Greenville to Panama City that are best for you.

Fly from

Greenville

Fly to

Panama City

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 10/28

6:45 am-6:38 pm

1 stop12h 53m

Panama City Tocumen Intl

Wed 11/5

8:55 am-9:59 pm

1 stop13h 04m

$391

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 8/13

6:44 pm-2:30 pm

2 stops20h 46m

Panama City Tocumen Intl

Tue 8/19

3:30 pm-11:41 am

2 stops19h 11m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Fri 8/8

4:05 pm-12:10 am

2 stops33h 05m

Panama City Tocumen Intl

Sun 8/10

8:10 pm-3:15 pm

3 stops18h 05m

$575

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 6/17

6:05 am-4:12 pm

1 stop11h 07m

$169

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 6/21

5:30 am-7:02 pm

1 stop14h 32m

$189

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 6/19

7:16 pm-1:00 pm

2 stops18h 44m

$202

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Fri 6/20

4:06 pm-12:35 pm

3 stops45h 29m

$311

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Best time to book a flight from Greenville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Panama City

What is the cheapest month to book a flight from Greenville to Panama City?

Currently, October is the cheapest month in which you can book a flight from Greenville to Panama City (average of $478). Flying from Greenville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to PTY?

Find hourly flight availability from Greenville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

When flying from Greenville to Panama City, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 35% versus a flight at noon.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated June 12, 2025.
See what other customers who have flown with Delta, United Airlines and American Airlines from Greenville to Panama City have to say. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,950 reviews
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Greenville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Greenville to Panama City round-trip?

    Flying on United Airlines is currently your cheapest option to Panama City, with prices starting at $391. Another option worth looking into is American Airlines, starting at $396 round trip. United Airlines is priced at 14% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Greenville to Panama City one-way?

    For one-way options, check prices for United Airlines. According to our data, you can fly for as low as $169. Users have also found prices from $189 and $202 on Delta and American Airlines, respectively.

  • Can I find deals for flights from Greenville to Panama City that include hotel bookings?

    Yes. In addition to deals on Greenville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Panama City.

  • Can I find deals for business class flights from Greenville to Panama City?

    Yes. Cheapflights offers flight deals from Greenville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Greenville to Panama City (average of $478). Flying from Greenville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Greenville to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to Panama City flights
Columbia to Panama City flights
Charleston to Panama City flights
Savannah to Panama City flights
Augusta to Panama City flights
Myrtle Beach to Panama City flights

Top 3 airlines flying from Greenville to Panama City

Discover the top 3 airlines that operate flights from Greenville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$285Average$401FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$352Average$577FlexibilityNo cancel feeOn-time71%
DeltaCheapest$371Average$482FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.