For a smooth departure from ORD, consider using the free shuttle train between terminals to save time navigating the sprawling layout.

Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $472 (Trip.com) |
One-way from | $180 (Kiwi.com) |
Popular in | December |
Cheapest in | October |
Average price | $746 |
Good round-trip deal | $437 or less |
Good one-way deal | $201 or less |
Fly from
Fly to
Route
Depart
Return
Price
ChicagoPanama City
ORD - PTY
ORDPTY
Chicago O'Hare Intl
Thu 1/22
6:57 pm-8:50 am
2 stops12h 53m
Panama City Tocumen Intl
Mon 1/26
9:33 pm-8:18 am
1 stop11h 45m
ChicagoPanama City
ORD - PTY
ORDPTY
Chicago O'Hare Intl
Tue 1/20
9:23 am-1:00 am
2 stops14h 37m
Panama City Tocumen Intl
Tue 1/27
9:33 pm-8:18 am
1 stop11h 45m
ChicagoPanama City
ORD - PTY
ORDPTY
Chicago O'Hare Intl
Mon 1/19
6:57 pm-8:50 am
2 stops12h 53m
Panama City Tocumen Intl
Fri 1/23
10:25 am-6:16 pm
1 stop8h 51m
ChicagoPanama City
ORD - PTY
ORDPTY
Chicago O'Hare Intl
Sun 1/18
6:57 pm-8:50 am
2 stops12h 53m
Panama City Tocumen Intl
Mon 1/26
9:33 pm-8:18 am
1 stop11h 45m
ChicagoPanama City
ORD - PTY
ORDPTY
Chicago O'Hare Intl
Sat 2/14
5:05 am-8:34 pm
1 stop14h 29m
Panama City Tocumen Intl
Tue 3/3
2:55 am-7:11 pm
2 stops17h 16m
ChicagoPanama City
ORD - PTY
ORDPTY
Chicago O'Hare Intl
Fri 3/27
3:22 pm-8:35 pm
Nonstop5h 13m
Panama City Tocumen Intl
Sat 4/4
7:25 pm-1:13 am
Nonstop5h 48m
ChicagoPanama City
ORD - PTY
ORDPTY
Chicago O'Hare Intl
Thu 4/2
3:21 pm-8:41 pm
Nonstop5h 20m
Panama City Tocumen Intl
Mon 4/6
7:25 pm-1:13 am
Nonstop5h 48m
ChicagoPanama City
ORD - PTY
ORDPTY
Chicago O'Hare Intl
Tue 4/7
3:21 pm-8:41 pm
Nonstop5h 20m
Panama City Tocumen Intl
Tue 4/14
8:10 am-1:58 pm
Nonstop5h 48m
ChicagoPanama City
ORD - PTY
ORDPTY
Chicago O'Hare Intl
Sat 3/28
3:22 pm-8:35 pm
Nonstop5h 13m
Panama City Tocumen Intl
Sat 4/4
7:25 pm-1:13 am
Nonstop5h 48m
ChicagoPanama City
ORD - PTY
ORDPTY
Chicago O'Hare Intl
Thu 4/9
8:06 am-1:22 pm
Nonstop5h 16m
Panama City Tocumen Intl
Mon 4/13
7:25 pm-1:13 am
Nonstop5h 48m
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*1 star | |
| Price Accuracy- | Trust Score*1 star | |
| Price Accuracy- | Trust Score*1 star | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*2 stars |
The best time to book flights from Chicago O'Hare Intl Airport to Panama City is 87 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
Currently, March is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Panama City (average of $398). Flying from Chicago O'Hare Intl Airport to Panama City in April is currently the most expensive (average of $464). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
One of the essential ways to save on airfare from Chicago O'Hare Intl Airport to Panama City is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 13% on airfare.
Travelers seeking maximum savings on their Chicago O'Hare Intl Airport to Panama City flight should consider departing on Monday evenings when fares are most often at their lowest. Wednesday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
About 8% of weekly flights between Chicago and Panama City have experienced delays in the past year, with the average delay time being 114 minutes.
Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving at night tend to experience delays more often.
Saturday tends to have the lowest number of delays on this route, whereas Sunday has historically faced a higher average of delays compared to other days of the week.
Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 8% of flights being delayed.
Overall
Boarding
Crew
Entertainment
Food
Comfort
Reviews
Jim,Nov 2025
AVL - ATL
Overall
Boarding
Crew
Entertainment
Food
Comfort
Reviews
Jim,Nov 2025
AVL - ATL
Overall
Boarding
Crew
Entertainment
Food
Comfort
Reviews
Jim,Nov 2025
AVL - ATL
Overall
Boarding
Crew
Entertainment
Food
Comfort
Reviews
Jim,Nov 2025
AVL - ATL
Overall
Boarding
Crew
Entertainment
Food
Comfort
Reviews
Jim,Nov 2025
AVL - ATL
Overall
Boarding
Crew
Entertainment
Food
Comfort
Reviews
Jim,Nov 2025
AVL - ATL
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$358 | Average$471 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$464 | Average$578 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$479 | Average$653 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$479 | Average$653 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$589 | Average$737 | FlexibilityNo cancel fee | On-time71% |