$222+ Cheap flights from Charlotte (CLT) to Panama City (PTY)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/10. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — PTY
May 29 — Jun 51
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Charlotte to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Charlotte to Panama City
Cheapest
Best
Last-minute
One-way
Cheapest flights from Charlotte to Panama CityExplore the most affordable flight options available from Charlotte to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.
Explore the most affordable flight options available from Charlotte to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.
This Mytrip deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1112:48 pm
CLT
- PTY
2 stops29h 12m
Multiple Airlines
Thu 5/143:10 pm
PTY
- CLT
2 stops19h 33m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$396
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:45 am
CLT
- PTY
1 stop7h 28m
Delta
Wed 9/162:21 pm
PTY
- CLT
1 stop8h 36m
Delta
Deal found 4/26![Delta logo]()
$449
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:15 am
CLT
- PTY
2 stops14h 16m
United Airlines
Wed 9/169:45 am
PTY
- CLT
1 stop9h 29m
United Airlines
Deal found 4/26![United Airlines logo]()
$453
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/611:45 am
CLT
- PTY
1 stop26h 28m
Delta
Wed 9/162:21 pm
PTY
- CLT
1 stop8h 36m
Delta
Deal found 4/26![Delta logo]()
$455
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/97:00 am
CLT
- PTY
1 stop22h 04m
United Airlines
Mon 7/1310:55 pm
PTY
- CLT
1 stop12h 12m
United Airlines
Deal found 4/28![United Airlines logo]()
$456
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:16 am
CLT
- PTY
1 stop9h 54m
American Airlines
Tue 9/223:40 pm
PTY
- CLT
1 stop15h 42m
American Airlines
Deal found 4/25![American Airlines logo]()
$459
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/107:00 am
CLT
- PTY
1 stop13h 31m
United Airlines
Thu 7/3010:55 pm
PTY
- CLT
1 stop9h 36m
United Airlines
Deal found 4/25![United Airlines logo]()
$474
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/68:00 am
CLT
- PTY
1 stop6h 13m
Delta
Thu 9/172:21 pm
PTY
- CLT
1 stop8h 36m
Delta
Deal found 4/26![Delta logo]()
$479
Best flights from Charlotte to Panama CityDiscover carefully curated flight deals from Charlotte to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 29, 2026.
Discover carefully curated flight deals from Charlotte to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 29, 2026.
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:30 am
CLT
- PTY
1 stop8h 26m
Delta
Wed 10/282:21 pm
PTY
- CLT
1 stop8h 32m
Delta
Deal found 4/28![Delta logo]()
$449
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:00 am
CLT
- PTY
2 stops23h 04m
United Airlines
Mon 7/139:45 am
PTY
- CLT
1 stop10h 17m
United Airlines
Deal found 4/28![United Airlines logo]()
$453
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/127:00 am
CLT
- PTY
1 stop13h 31m
United Airlines
Wed 7/153:30 pm
PTY
- CLT
1 stop18h 32m
United Airlines
Deal found 4/28![United Airlines logo]()
$479
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:30 am
CLT
- PTY
1 stop8h 26m
Delta
Wed 9/162:21 pm
PTY
- CLT
1 stop8h 36m
Delta
Deal found 4/25![Delta logo]()
$479
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:49 pm
CLT
- PTY
2 stops24h 42m
United Airlines
Fri 9/183:30 pm
PTY
- CLT
2 stops21h 20m
United Airlines
Deal found 4/27![United Airlines logo]()
$483
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/78:05 am
CLT
- PTY
2 stops11h 32m
United Airlines
Sun 8/910:55 pm
PTY
- CLT
2 stops24h 04m
United Airlines
Deal found 4/29![United Airlines logo]()
$526
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:00 am
CLT
- PTY
1 stop13h 31m
United Airlines
Sat 6/610:00 am
PTY
- CLT
1 stop10h 59m
United Airlines
Deal found 4/28![United Airlines logo]()
$529
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:00 am
CLT
- PTY
1 stop13h 31m
United Airlines
Wed 6/109:45 am
PTY
- CLT
2 stops13h 14m
United Airlines
Deal found 4/25![United Airlines logo]()
$533
Last-minute flights from Charlotte to Panama CityDiscover last-minute flight deals from Charlotte to Panama City. Data last updated April 29, 2026 and is based on user searches.
Discover last-minute flight deals from Charlotte to Panama City. Data last updated April 29, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:46 am
CLT
- PTY
1 stop7h 16m
Delta
Sat 12/268:00 am
PTY
- CLT
1 stop13h 33m
Delta
Deal found 4/27![Delta logo]()
$534
This Mytrip deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1012:48 pm
CLT
- PTY
2 stops21h 27m
Multiple Airlines
Sat 5/165:55 pm
PTY
- CLT
2 stops16h 48m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$514
This Mytrip deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1112:48 pm
CLT
- PTY
2 stops29h 12m
Multiple Airlines
Thu 5/143:10 pm
PTY
- CLT
2 stops19h 33m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$396
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:00 am
CLT
- PTY
1 stop13h 31m
United Airlines
Tue 5/193:30 pm
PTY
- CLT
1 stop18h 26m
United Airlines
Deal found 4/28![United Airlines logo]()
$559
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:00 am
CLT
- PTY
1 stop13h 31m
United Airlines
Mon 6/83:30 pm
PTY
- CLT
1 stop29h 29m
United Airlines
Deal found 4/28![United Airlines logo]()
$509
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:00 am
CLT
- PTY
1 stop13h 31m
United Airlines
Sun 6/77:55 am
PTY
- CLT
1 stop13h 04m
United Airlines
Deal found 4/28![United Airlines logo]()
$529
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:00 am
CLT
- PTY
2 stops14h 31m
United Airlines
Sat 6/610:00 am
PTY
- CLT
1 stop10h 59m
United Airlines
Deal found 4/28![United Airlines logo]()
$533
One-way flights from Charlotte to Panama CitySearch for one-way flight options from Charlotte to Panama City. Find affordable one-way fares based on user searches. Data last updated April 29, 2026.
Search for one-way flight options from Charlotte to Panama City. Find affordable one-way fares based on user searches. Data last updated April 29, 2026.
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/108:05 am
CLT
- PTY
2 stops20h 59m
United Airlines
Deal found 4/26![United Airlines logo]()
$222
This Mytrip deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/79:07 pm
CLT
- PTY
2 stops24h 35m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$280
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:00 am
CLT
- PTY
1 stop12h 37m
United Airlines
Deal found 4/25![United Airlines logo]()
$288
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:40 pm
CLT
- PTY
3 stops30h 55m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$310
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:30 am
CLT
- PTY
1 stop8h 44m
United Airlines
Deal found 4/28![United Airlines logo]()
$333
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/99:07 pm
CLT
- PTY
2 stops24h 35m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$337
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:59 am
CLT
- PTY
1 stop6h 51m
Delta
Deal found 4/26![Delta logo]()
$368
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1010:14 pm
CLT
- PTY
3 stops23h 23m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$643
Find flight deals from Charlotte to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Charlotte (CLT) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $396 (Mytrip) |
One-way from | $222 (United Airlines) |
Popular in | December |
Cheapest in | September |
Average price | $562 |
Cheapflights Fare Finder
Customize your flight search to find flights from Charlotte to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
Use the filters below to find and compare flights from Charlotte to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
Wed 10/21
5:30 am-12:56 pm
1 stop8h 26m
Panama City Tocumen Intl
Wed 10/28
2:21 pm-11:53 pm
1 stop8h 32m
$449
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
Thu 7/9
6:00 am-4:04 am
2 stops23h 04m
Panama City Tocumen Intl
Mon 7/13
9:45 am-9:02 pm
1 stop10h 17m
$453
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
Sun 7/12
7:00 am-7:31 pm
1 stop13h 31m
Panama City Tocumen Intl
Wed 7/15
3:30 pm-11:02 am
1 stop18h 32m
$479
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
Sat 9/12
5:30 am-12:56 pm
1 stop8h 26m
Panama City Tocumen Intl
Wed 9/16
2:21 pm-11:57 pm
1 stop8h 36m
$479
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
Sun 9/6
7:49 pm-7:31 pm
2 stops24h 42m
Panama City Tocumen Intl
Fri 9/18
3:30 pm-1:50 pm
2 stops21h 20m
$483
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
Fri 8/7
8:05 am-6:37 pm
2 stops11h 32m
Panama City Tocumen Intl
Sun 8/9
10:55 pm-11:59 pm
2 stops24h 04m
$526
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
Wed 5/27
7:00 am-7:31 pm
1 stop13h 31m
Panama City Tocumen Intl
Sat 6/6
10:00 am-9:59 pm
1 stop10h 59m
$529
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
Mon 6/1
7:00 am-7:31 pm
1 stop13h 31m
Panama City Tocumen Intl
Wed 6/10
9:45 am-11:59 pm
2 stops13h 14m
$533
Cheapest one-way
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
Fri 7/10
8:05 am-4:04 am
2 stops20h 59m
$222
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
Thu 5/7
9:07 pm-8:42 pm
2 stops24h 35m
$280
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Charlotte to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charlotte to Panama City in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Charlotte-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charlotte-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charlotte-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Charlotte-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charlotte-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Charlotte to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Charlotte with our price prediction graph.
CLT-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Charlotte to Panama City
How far ahead should I book a flight from Charlotte to Panama City?
Booking 25 days in advance of your planned departure date is, on average, the best time to get cheap flights from Charlotte to Panama City. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Charlotte to Panama City?
Currently, September is the cheapest month in which you can book a flight from Charlotte to Panama City (average of $492). Flying from Charlotte to Panama City in December is currently the most expensive (average of $727). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Charlotte to Panama City?
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated April 29, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Charlotte to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
7.9
Overall
7.9
Entertainment
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Boarding
8.1
Comfort
7.9
Overall
7.9
Entertainment
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Boarding
8.1
Comfort
7.9
Overall
7.9
Entertainment
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Boarding
8.1
Comfort
7.9
Overall
7.9
Entertainment
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Charlotte to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Charlotte
Panama City flight routes
Popular flights
Alternative routes for Charlotte to Panama City
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Charlotte to Panama City by cabin class
Find flights from Charlotte to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Charlotte and Panama City flights
Browse other Charlotte and Panama City flight options. Last updated on April 29, 2026.
Other flights from Charlotte
Browse through other flights departing from Charlotte. Flights are based on user searches made on Cheapflights and were last updated on April 29, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Charlotte to Panama City
Discover the top 3 airlines that operate flights from Charlotte to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$431 | Average$577 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$441 | Average$585 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$467 | Average$547 | FlexibilityNo cancel fee | On-time69% |