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$491+ Cheap flights from Biloxi, MS to Panama City (PTY)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/7. Fares are subject to change and may not be available on all flights or dates of travel.
MSY — PTY
Jan 25 — Feb 11
Sun 1/25
Sun 2/1
1 adult, Economy
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Cheap flight deals from Biloxi to Panama City

Cheapest flights from Biloxi to Panama City
Explore the most affordable flight options available from Biloxi to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 26, 2025.

This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:48 pmGPT - PTY
2 stops22h 06mAmerican Airlines
Fri 1/94:50 pmPTY - GPT
2 stops20h 41mAmerican Airlines
Deal found 12/24$1,548
This Delta deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3010:42 amGPT - PTY
1 stop8h 18mDelta
Fri 1/93:20 pmPTY - GPT
1 stop7h 33mDelta
Deal found 12/24$2,757

Find flight deals from Biloxi to Panama City

Keep the following information in mind while searching for Biloxi to Panama City flight deals. Data was last updated December 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$491
(United Airlines)

Popular in

December

Cheapest in

April

Average price

$983
Provider with most accurate pricing for Gulfport Biloxi Regional-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Gulfport Biloxi Regional-Panama City Tocumen Intl flights.
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From Biloxi to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($189 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($34 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Biloxi to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 26, 2025.
Use the filters below to find and compare flights from Biloxi to Panama City that are best for you.

Fly from

Biloxi

Fly to

Panama City

Route

Depart

Return

Price

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

Sat 2/7

5:13 pm-7:38 pm

1 stop25h 25m

Panama City Tocumen Intl

Wed 2/11

4:41 pm-4:01 pm

1 stop24h 20m

$491

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/23

Best time to book a flight from Biloxi to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Biloxi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Biloxi to Panama City

What is the cheapest month to book a flight from Biloxi to Panama City?

Currently, September is the cheapest month in which you can book a flight from Biloxi to Panama City (average of $346). Flying from Biloxi to Panama City in January is currently the most expensive (average of $487). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from B1L to PTY?

Find hourly flight availability from Biloxi to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 26, 2025.

One of the essential ways to save on airfare from Biloxi to Panama City is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 23% on airfare.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated December 26, 2025.
Read through reviews of airlines operating flights from Biloxi to Panama City, such as United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,115 reviews

Food

6.6

Overall

7.4

Boarding

7.7

Comfort

7.3

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Michelle,Dec 2025

DEN - MKE

I liked that the plane waited 5 minutes for a family whose incoming plane was late. This was the last flight of the day to MKE. Flight attendants actually checked in throughout the flight. Although, not really friendly. Happy to see screens on seat backs again. This is my first time not flying first class in over 10 years. It was economy plus.
United Airlines
7.4
Good
9,115 reviews
United Airlines
7.4
Good
9,115 reviews

Food

6.6

Overall

7.4

Boarding

7.7

Comfort

7.3

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Michelle,Dec 2025

DEN - MKE

I liked that the plane waited 5 minutes for a family whose incoming plane was late. This was the last flight of the day to MKE. Flight attendants actually checked in throughout the flight. Although, not really friendly. Happy to see screens on seat backs again. This is my first time not flying first class in over 10 years. It was economy plus.

Related info for your journey

Find useful and relevant information for your journey from Biloxi to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Biloxi?

    If you book a flight to Panama City from Biloxi, you will be flying to Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City. There are 0 flights from Biloxi to Tocumen Intl per day from 3 different airlines.

  • How long is the flight from Biloxi to Panama City?

    United Airlines can get you from Biloxi to Panama City in just under 25h 25m. Your travel time can differ by up to . There are 1600 mi between Biloxi and Panama City.

  • Can I find deals for flights from Biloxi to Panama City that include hotel bookings?

    Yes. In addition to deals on Biloxi to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Biloxi to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Biloxi to Panama City.

  • Can I find deals for business class flights from Biloxi to Panama City?

    Yes. Cheapflights offers flight deals from Biloxi to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Biloxi to Panama City?

    Currently, September is the cheapest month in which you can book a flight from Biloxi to Panama City (average of $346). Flying from Biloxi to Panama City in January is currently the most expensive (average of $487). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Biloxi to Panama City

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Top 3 airlines flying from Biloxi to Panama City

Discover the top 3 airlines that operate flights from Biloxi to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$385Average$433FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$391Average$534FlexibilityNo cancel feeOn-time69%
DeltaCheapest$411Average$521FlexibilityNo cancel feeOn-timeN/A

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