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Panama City

$212+ Cheap flights from Irvine, CA to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/4. Fares are subject to change and may not be available on all flights or dates of travel.
LAX — PTY
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheapflights Tip: The best prices from Irvine to Panama City Tocumen Intl are usually found in September or August, booked 50 days in advance, depart on a Wednesday or Monday and return on a Tuesday

Cheap flight deals from Irvine to Panama City

Keep the following information in mind while searching for Irvine to Panama City flight deals. Data was last updated September 15, 2025.

Round-trip from

$489
(Mytrip)

One-way from

$212
(Kiwi.com)

Popular in

December

Cheapest in

September

Average price

$518
From Irvine to Panama City Tocumen Intl
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One-way flight from Irvine to Panama City Tocumen Intl
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Highest demand for flights based on searches. 4% potential increase in price ($28 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Irvine to Panama City

Cheapest flights from Irvine to Panama City
Explore the most affordable flight options available from Irvine to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1511:50 pmLAX - PTY
1 stop8h 35mAvianca
Fri 9/193:40 pmPTY - LAX
1 stop8h 50mAvianca
Deal found 9/15$488
This Mytrip deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/27:50 pmLAX - PTY
3 stops26h 55mMultiple Airlines
Mon 10/63:25 amPTY - LAX
3 stops30h 52mMultiple Airlines
Deal found 9/14$489
This Cheapflightsfares deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/162:50 pmLAX - PTY
3 stops17h 20mAvianca
Mon 9/223:40 pmPTY - LAX
1 stop8h 50mAvianca
Deal found 9/13$490
This Cheapflightsfares deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/132:50 pmLAX - PTY
3 stops17h 20mAvianca
Sat 9/208:10 pmPTY - LAX
2 stops17h 50mAvianca
Deal found 9/13$492
This Cheapflightsfares deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/141:00 amLAX - PTY
1 stop13h 15mAvianca
Mon 9/2910:05 pmPTY - LAX
2 stops16h 25mAvianca
Deal found 9/13$494
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2912:09 amLAX - PTY
2 stops18h 10mMultiple Airlines
Thu 11/612:03 pmPTY - LAX
1 stop12h 36mMultiple Airlines
Deal found 9/15$497
This Mytrip deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/81:00 pmLAX - PTY
2 stops16h 50mMultiple Airlines
Wed 11/127:50 pmPTY - LAX
1 stop17h 45mMultiple Airlines
Deal found 9/14$518

Cheapflights Fare Finder

 
Customize your flight search to find flights from Irvine to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Irvine to Panama City that are best for you.

Fly from

Irvine

Fly to

Panama City

Route

Depart

Return

Price

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Thu 1/15

10:55 pm-10:20 am

1 stop8h 25m

Panama City Tocumen Intl

Mon 1/19

9:45 am-10:00 pm

2 stops15h 15m

$538

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Sun 1/11

10:55 pm-10:20 am

1 stop8h 25m

Panama City Tocumen Intl

Sat 1/17

7:50 pm-10:55 am

2 stops18h 05m

$548

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Wed 2/11

9:08 pm-6:37 am

Nonstop6h 29m

Panama City Tocumen Intl

Sat 2/28

7:55 am-12:05 pm

Nonstop7h 10m

$598

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Mon 1/19

1:11 am-10:25 am

Nonstop6h 14m

Panama City Tocumen Intl

Sun 1/25

6:24 pm-10:36 pm

Nonstop7h 12m

$598

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Tue 11/11

9:04 pm-6:37 am

Nonstop6h 33m

Panama City Tocumen Intl

Wed 11/19

6:14 pm-10:34 pm

Nonstop7h 20m

$608

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Sat 11/8

10:45 pm-1:00 am

3 stops23h 15m

$213

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Sun 10/5

2:54 pm-9:10 pm

3 stops28h 16m

$229

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Mon 10/13

2:50 pm-4:30 pm

2 stops23h 40m

$232

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Fri 9/26

1:00 am-4:15 pm

1 stop13h 15m

$236

Los AngelesPanama City

LAX - PTY

LAXPTY

Los Angeles

Sat 11/8

11:20 pm-10:20 am

1 stop8h 00m

$237

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 16 results
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Best time to book a flight from Irvine to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Irvine with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Irvine to Panama City

How far ahead should I book a flight from Irvine to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Irvine to Panama City. Price data was last updated on September 12, 2025.

Booking 50 days in advance of your planned departure date is, on average, the best time to get cheap flights from Irvine to Panama City. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Irvine to Panama City?

Currently, October is the cheapest month in which you can book a flight from Irvine to Panama City (average of $478). Flying from Irvine to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IR9 to PTY?

Find hourly flight availability from Irvine to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Irvine to Panama City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Weekly flight availability from Irvine to Panama City

Explore weekly flight availability from Irvine to Panama City. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 15, 2025.

The most flights from IR9 to PTY are scheduled on a Monday (9 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (9 on average).

How much does it cost to fly round-trip from Irvine to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 15, 2025.
Get a feel of what it's like to fly with Delta, Copa Airlines, and United Airlines from Irvine to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,531 reviews
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,929 reviews
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,435 reviews
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Irvine to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Irvine?

    Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly into when you book flights from Irvine to Panama City. 5 airlines have flights to Tocumen Intl from Irvine on a regular basis. Booking flights from Irvine to Panama City Tocumen Intl should not be difficult; the airport handles an average of 9 inbound flights from Irvine per day.

  • How popular is this Irvine to Panama City flight route?

    Within the past month, 160 users have taken a look at flights from Irvine to Panama City Tocumen Intl.

  • How long is the flight from Irvine to Panama City?

    For as low as $538, Avianca can have you in Panama City from Irvine in 8h 25m. Airlines will cover a distance of 3009 mi.

  • What are the most reliable airlines from Irvine to Panama City?

    No one likes to see their flight delayed. When booking a flight from Irvine to Panama City consider choosing EVA Air (88%), Asiana Airlines (88%) or United Airlines (88%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Irvine to Panama City?

    While on average a flight from Irvine to Panama City is generally $1,222, our data shows the cheapest flight currently is $166. When looking at the most popular route, (Los Angeles - Panama City Tocumen Intl), you can expect to pay $523 for that flight.

  • Can I find deals for flights from Irvine to Panama City that include hotel bookings?

    Yes. In addition to deals on Irvine to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Irvine to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Irvine to Panama City.

  • Can I find deals for business class flights from Irvine to Panama City?

    Yes. Cheapflights offers flight deals from Irvine to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Irvine to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Irvine to Panama City (average of $478). Flying from Irvine to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 5 airlines flying from Irvine to Panama City

Discover the top 5 airlines that operate flights from Irvine to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$203Average$542FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$299Average$653FlexibilityNo cancel feeOn-time69%
AviancaCheapest$341Average$502FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$495Average$636FlexibilityNo cancel feeOn-time70%
DeltaCheapest$519Average$715FlexibilityNo cancel feeOn-timeN/A

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