$301+ Cheap flights from Sioux Falls to Panama City, FL (FSD - ECP)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — ECP
Oct 8 — Oct 151
Round-trip
1 adult, Economy
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Find cheap flights from Sioux Falls to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Sioux Falls to Panama City
Cheapest
Best
Last-minute
Cheapest flights from Sioux Falls to Panama CityExplore the most affordable flight options available from Sioux Falls to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
Explore the most affordable flight options available from Sioux Falls to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:53 pm -
2 stops11h 00m
Sat 10/317:15 am -
2 stops13h 58m
Deal found 9/7![American Airlines logo]()
$311
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:53 pm -
1 stop5h 19m
Sat 10/317:15 am -
2 stops11h 50m
Deal found 9/7![American Airlines logo]()
$345
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:00 am -
1 stop5h 42m
Sat 9/263:17 pm -
1 stop5h 28m
Deal found 9/4![American Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/225:30 am -
1 stop7h 09m
Thu 10/11:46 pm -
1 stop6h 01m
Deal found 9/5![Delta logo]()
$374
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:50 am -
1 stop5h 13m
Wed 10/212:50 pm -
2 stops8h 54m
Deal found 9/4![United Airlines logo]()
$396
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:30 am -
1 stop7h 09m
Thu 9/241:46 pm -
1 stop6h 01m
Deal found 9/5![Delta logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:50 am -
1 stop5h 12m
Sat 10/313:15 pm -
1 stop8h 29m
Deal found 9/7![United Airlines logo]()
$403
Best flights from Sioux Falls to Panama CityDiscover carefully curated flight deals from Sioux Falls to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
Discover carefully curated flight deals from Sioux Falls to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/237:03 am -
1 stop5h 27m
Tue 3/21:06 pm -
1 stop5h 59m
Deal found 9/3![American Airlines logo]()
$301
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/97:40 am -
1 stop5h 37m
Tue 1/192:08 pm -
1 stop8h 15m
Deal found 9/6![United Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2212:56 pm -
1 stop8h 11m
Sat 9/263:17 pm -
1 stop5h 28m
Deal found 9/8![American Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/237:40 am -
1 stop5h 37m
Wed 1/272:08 pm -
1 stop8h 15m
Deal found 9/3![United Airlines logo]()
$391
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:50 am -
1 stop5h 13m
Sat 10/246:20 am -
2 stops10h 03m
Deal found 9/4![United Airlines logo]()
$396
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:08 pm -
1 stop7h 51m
Tue 11/108:19 am -
2 stops10h 29m
Deal found 9/7![American Airlines logo]()
$404
Last-minute flights from Sioux Falls to Panama CityDiscover last-minute flight deals from Sioux Falls to Panama City. Data last updated September 8, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Panama City. Data last updated September 8, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:30 am -
1 stop7h 09m
Thu 9/241:46 pm -
1 stop6h 01m
Deal found 9/5![Delta logo]()
$399
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:00 am -
1 stop5h 42m
Sat 9/263:17 pm -
1 stop5h 28m
Deal found 9/4![American Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/225:30 am -
1 stop7h 09m
Thu 10/11:46 pm -
1 stop6h 01m
Deal found 9/5![Delta logo]()
$374
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:50 am -
1 stop5h 13m
Sat 10/246:20 am -
2 stops10h 03m
Deal found 9/4![United Airlines logo]()
$396
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:53 pm -
1 stop5h 19m
Sat 10/317:15 am -
2 stops11h 50m
Deal found 9/7![American Airlines logo]()
$345
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:53 pm -
2 stops11h 00m
Sat 10/317:15 am -
2 stops13h 58m
Deal found 9/7![American Airlines logo]()
$311
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:50 am -
1 stop5h 12m
Sat 10/313:15 pm -
1 stop8h 29m
Deal found 9/7![United Airlines logo]()
$403
Find flight deals from Sioux Falls to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Sioux Falls (FSD) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $301 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
Use the filters below to find and compare flights from Sioux Falls to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Sioux FallsPanama City
FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches
FSDECP
Sioux Falls Joe Foss Field
Tue 2/23
7:03 am-12:30 pm
1 stop5h 27m
Panama City NW Florida Beaches
Tue 3/2
1:06 pm-7:05 pm
1 stop5h 59m
$301
Sioux FallsPanama City
FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches
FSDECP
Sioux Falls Joe Foss Field
Sat 1/9
7:40 am-1:17 pm
1 stop5h 37m
Panama City NW Florida Beaches
Tue 1/19
2:08 pm-10:23 pm
1 stop8h 15m
$321
Sioux FallsPanama City
FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches
FSDECP
Sioux Falls Joe Foss Field
Tue 9/22
12:56 pm-9:07 pm
1 stop8h 11m
Panama City NW Florida Beaches
Sat 9/26
3:17 pm-8:45 pm
1 stop5h 28m
$379
Sioux FallsPanama City
FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches
FSDECP
Sioux Falls Joe Foss Field
Sat 1/23
7:40 am-1:17 pm
1 stop5h 37m
Panama City NW Florida Beaches
Wed 1/27
2:08 pm-10:23 pm
1 stop8h 15m
$391
Sioux FallsPanama City
FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches
FSDECP
Sioux Falls Joe Foss Field
Tue 10/6
7:50 am-1:03 pm
1 stop5h 13m
Panama City NW Florida Beaches
Sat 10/24
6:20 am-4:23 pm
2 stops10h 03m
$396
Sioux FallsPanama City
FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches
FSDECP
Sioux Falls Joe Foss Field
Fri 11/6
1:08 pm-8:59 pm
1 stop7h 51m
Panama City NW Florida Beaches
Tue 11/10
8:19 am-6:48 pm
2 stops10h 29m
$404
Sorted by cheapest first
Compare providers for flights from Sioux Falls to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Sioux Falls to Panama City in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Sioux Falls-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Sioux Falls-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Sioux Falls-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Sioux Falls-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Sioux Falls-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Sioux Falls to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Sioux Falls with our price prediction graph.
FSD-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 8, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Sioux Falls to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Boarding
8.1
Food
7.2
Comfort
7.8
Crew
8.5
Overall
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Entertainment
7.8
Boarding
8.1
Food
7.2
Comfort
7.8
Crew
8.5
Overall
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Entertainment
7.8
Boarding
8.1
Food
7.2
Comfort
7.8
Crew
8.5
Overall
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
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Sioux Falls and Panama City flights
Browse other Sioux Falls and Panama City flight options. Last updated on September 8, 2026.
Other flights from Sioux Falls
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Top 2 airlines flying from Sioux Falls to Panama City
Discover the top 2 airlines that operate flights from Sioux Falls to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$279 | Average$400 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$310 | Average$418 | FlexibilityNo cancel fee | On-timeN/A |