$340+ Cheap flights from Sioux Falls to Panama City, FL (FSD - ECP)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/27. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — ECP
Nov 4 — Nov 111
Round-trip
1 adult, Economy
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Find cheap flights from Sioux Falls to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Sioux Falls to Panama City
Cheapest
Best
Last-minute
One-way
Cheapest flights from Sioux Falls to Panama CityExplore the most affordable flight options available from Sioux Falls to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 5, 2026.
Explore the most affordable flight options available from Sioux Falls to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 5, 2026.
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:20 am -
1 stop5h 18m
Sat 10/317:15 am -
2 stops10h 08m
Deal found 9/30![American Airlines logo]()
$340
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:20 am -
1 stop5h 18m
Sat 10/317:15 am -
2 stops11h 50m
Deal found 9/30![American Airlines logo]()
$365
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/41:04 pm -
1 stop7h 51m
Mon 12/712:13 pm -
1 stop8h 44m
Deal found 10/1![American Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:00 am -
2 stops10h 09m
Tue 11/247:00 am -
1 stop5h 33m
Deal found 10/1![American Airlines logo]()
$415
This Delta deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:30 am -
1 stop5h 05m
Sun 11/12:35 pm -
1 stop5h 20m
Deal found 10/4![Delta logo]()
$419
This Delta deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/48:27 am -
2 stops6h 34m
Mon 12/79:23 am -
2 stops9h 51m
Deal found 10/1![Delta logo]()
$429
This United Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am -
2 stops10h 18m
Tue 11/109:06 am -
2 stops10h 58m
Deal found 10/1![United Airlines logo]()
$439
This Delta deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:25 am -
1 stop7h 17m
Tue 11/241:34 pm -
1 stop6h 22m
Deal found 10/1![Delta logo]()
$440
This Delta deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:00 pm -
2 stops10h 18m
Mon 11/25:37 pm -
2 stops29h 45m
Deal found 10/1![Delta logo]()
$442
Best flights from Sioux Falls to Panama CityDiscover carefully curated flight deals from Sioux Falls to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 5, 2026.
Discover carefully curated flight deals from Sioux Falls to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 5, 2026.
This United Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/235:50 am -
1 stop7h 37m
Wed 1/272:10 pm -
1 stop8h 11m
Deal found 10/4![United Airlines logo]()
$431
This Delta deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:25 am -
1 stop7h 17m
Tue 11/241:34 pm -
1 stop6h 22m
Deal found 10/1![Delta logo]()
$440
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:00 am -
2 stops10h 18m
Sat 10/319:06 am -
2 stops10h 58m
Deal found 9/30![United Airlines logo]()
$455
Last-minute flights from Sioux Falls to Panama CityDiscover last-minute flight deals from Sioux Falls to Panama City. Data last updated October 5, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Panama City. Data last updated October 5, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:20 am -
1 stop5h 18m
Sat 10/317:15 am -
2 stops10h 08m
Deal found 9/30![American Airlines logo]()
$340
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:00 am -
2 stops10h 18m
Sat 10/313:15 pm -
1 stop8h 29m
Deal found 9/30![United Airlines logo]()
$450
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:20 am -
1 stop5h 18m
Sat 10/317:15 am -
2 stops11h 50m
Deal found 9/30![American Airlines logo]()
$365
This Delta deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:30 am -
1 stop5h 05m
Sun 11/12:35 pm -
1 stop5h 20m
Deal found 10/4![Delta logo]()
$454
This Delta deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:30 am -
1 stop5h 05m
Sun 11/12:35 pm -
1 stop5h 20m
Deal found 10/4![Delta logo]()
$419
This Delta deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:00 pm -
2 stops10h 18m
Mon 11/25:37 pm -
2 stops29h 45m
Deal found 10/1![Delta logo]()
$442
This United Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am -
2 stops10h 18m
Tue 11/109:06 am -
2 stops10h 58m
Deal found 10/1![United Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:00 am -
2 stops10h 09m
Tue 11/247:00 am -
1 stop5h 33m
Deal found 10/1![American Airlines logo]()
$415
This Delta deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:25 am -
1 stop7h 17m
Tue 11/241:34 pm -
1 stop6h 22m
Deal found 10/1![Delta logo]()
$440
One-way flights from Sioux Falls to Panama CitySearch for one-way flight options from Sioux Falls to Panama City. Find affordable one-way fares based on user searches. Data last updated October 5, 2026.
Search for one-way flight options from Sioux Falls to Panama City. Find affordable one-way fares based on user searches. Data last updated October 5, 2026.
This United Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 am -
2 stops10h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/1![United Airlines logo]()
$535
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1512:53 pm -
1 stop5h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![American Airlines logo]()
$591
Find flight deals from Sioux Falls to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Sioux Falls (FSD) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $321 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 5, 2026.
Use the filters below to find and compare flights from Sioux Falls to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsPanama City
FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches
FSDECP
Sioux Falls Joe Foss Field
Sat 1/23
5:50 am-1:27 pm
1 stop7h 37m
Panama City NW Florida Beaches
Wed 1/27
2:10 pm-10:21 pm
1 stop8h 11m
$431
Sioux FallsPanama City
FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches
FSDECP
Sioux Falls Joe Foss Field
Tue 11/10
5:25 am-12:42 pm
1 stop7h 17m
Panama City NW Florida Beaches
Tue 11/24
1:34 pm-7:56 pm
1 stop6h 22m
$440
Sioux FallsPanama City
FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches
FSDECP
Sioux Falls Joe Foss Field
Tue 10/27
6:00 am-4:18 pm
2 stops10h 18m
Panama City NW Florida Beaches
Sat 10/31
9:06 am-8:04 pm
2 stops10h 58m
$455
Sioux FallsPanama City
FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches
FSDECP
Sioux Falls Joe Foss Field
Thu 10/15
6:00 am-4:13 pm
2 stops10h 13m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$535
Quickest round-trip
Sioux FallsPanama City
FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches
FSDECP
Sioux Falls Joe Foss Field
Thu 10/15
12:53 pm-6:12 pm
1 stop5h 19m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$591
Sorted by cheapest first
Compare providers for flights from Sioux Falls to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Sioux Falls to Panama City in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Sioux Falls-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Sioux Falls-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Sioux Falls-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Sioux Falls-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Sioux Falls-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Sioux Falls to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Sioux Falls with our price prediction graph.
FSD-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated October 5, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Sioux Falls to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Boarding
8.1
Overall
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Boarding
8.1
Overall
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Sioux Falls to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Sioux Falls and Panama City flights
Browse other Sioux Falls and Panama City flight options. Last updated on October 5, 2026.
Other flights from Sioux Falls
Browse through other flights departing from Sioux Falls. Flights are based on user searches made on Cheapflights and were last updated on October 5, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Sioux Falls to Panama City
Discover the top 2 airlines that operate flights from Sioux Falls to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$279 | Average$398 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$310 | Average$418 | FlexibilityNo cancel fee | On-timeN/A |