$127+ Cheap flights from Detroit to Panama City, FL (DTT - ECP)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — ECP
Oct 18 — Oct 251
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to Panama City
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Cheapest flights from Detroit to Panama CityExplore the most affordable flight options available from Detroit to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
Explore the most affordable flight options available from Detroit to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/31:25 pm -
1 stop5h 45m
Tue 11/107:30 am -
2 stops9h 30m
Deal found 9/15![Southwest logo]()
$212
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/148:25 am -
1 stop5h 10m
Wed 10/216:00 am -
1 stop4h 30m
Deal found 9/14![Delta logo]()
$219
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:05 am -
2 stops5h 25m
Tue 11/37:55 am -
1 stop4h 25m
Deal found 9/17![Southwest logo]()
$224
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:55 pm -
1 stop4h 58m
Mon 10/196:42 pm -
1 stop4h 53m
Deal found 9/14![American Airlines logo]()
$232
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:40 pm -
1 stop6h 38m
Tue 10/205:34 pm -
1 stop6h 24m
Deal found 9/14![Delta logo]()
$233
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:20 am -
1 stop3h 54m
Tue 10/205:34 pm -
1 stop6h 24m
Deal found 9/14![Delta logo]()
$236
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:25 am -
1 stop6h 10m
Thu 10/156:00 am -
1 stop4h 30m
Deal found 9/14![Delta logo]()
$244
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:46 pm -
1 stop5h 32m
Tue 10/205:34 pm -
1 stop6h 24m
Deal found 9/14![Delta logo]()
$249
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:50 pm -
1 stop4h 28m
Wed 10/216:00 am -
1 stop6h 06m
Deal found 9/14![Delta logo]()
$259
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:46 pm -
1 stop5h 32m
Thu 10/159:19 am -
1 stop6h 58m
Deal found 9/14![Delta logo]()
$261
Best flights from Detroit to Panama CityDiscover carefully curated flight deals from Detroit to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
Discover carefully curated flight deals from Detroit to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am -
2 stops10h 35m
Tue 11/107:30 am -
2 stops9h 30m
Deal found 9/15![Southwest logo]()
$217
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:50 pm -
1 stop4h 28m
Sat 10/177:12 am -
1 stop4h 54m
Deal found 9/16![Delta logo]()
$306
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:30 am -
2 stops9h 33m
Sat 10/319:06 am -
2 stops10h 52m
Deal found 9/16![United Airlines logo]()
$392
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:50 am -
1 stop4h 45m
Mon 11/95:55 pm -
1 stop4h 00m
Deal found 9/15![Southwest logo]()
$513
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/245:20 am -
1 stop3h 56m
Mon 9/281:46 pm -
1 stop6h 23m
Deal found 9/13![Delta logo]()
$554
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:35 am -
2 stops9h 50m
Fri 10/231:50 pm -
2 stops8h 15m
Deal found 9/16![Southwest logo]()
$539
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:20 pm -
1 stop5h 05m
Sat 10/35:30 pm -
1 stop6h 24m
Deal found 9/14![Delta logo]()
$554
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/245:20 am -
1 stop3h 56m
Sun 9/276:00 am -
1 stop4h 15m
Deal found 9/13![Delta logo]()
$554
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/207:00 am -
1 stop3h 50m
Tue 9/2211:30 am -
2 stops9h 25m
Deal found 9/16![Southwest logo]()
$575
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2510:30 am -
1 stop6h 01m
Mon 9/286:19 pm -
1 stop5h 35m
Deal found 9/13![Delta logo]()
$554
Last-minute flights from Detroit to Panama CityDiscover last-minute flight deals from Detroit to Panama City. Data last updated September 18, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to Panama City. Data last updated September 18, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:55 pm -
1 stop4h 58m
Mon 10/196:42 pm -
1 stop4h 53m
Deal found 9/14![American Airlines logo]()
$232
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:46 pm -
1 stop5h 32m
Wed 10/212:45 pm -
1 stop5h 13m
Deal found 9/14![Delta logo]()
$249
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/125:20 am -
1 stop3h 54m
Thu 10/156:00 am -
1 stop4h 30m
Deal found 9/14![Delta logo]()
$274
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:20 am -
1 stop3h 54m
Tue 10/205:34 pm -
1 stop6h 24m
Deal found 9/14![Delta logo]()
$236
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:46 pm -
1 stop5h 32m
Thu 10/159:19 am -
1 stop6h 58m
Deal found 9/14![Delta logo]()
$261
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:50 pm -
1 stop4h 28m
Tue 10/205:34 pm -
1 stop6h 24m
Deal found 9/14![Delta logo]()
$219
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:25 am -
1 stop6h 10m
Thu 10/156:00 am -
1 stop4h 30m
Deal found 9/14![Delta logo]()
$244
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:50 pm -
1 stop4h 28m
Tue 10/205:34 pm -
1 stop5h 19m
Deal found 9/14![Delta logo]()
$259
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:40 pm -
1 stop6h 38m
Tue 10/205:34 pm -
1 stop6h 24m
Deal found 9/14![Delta logo]()
$233
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:20 am -
1 stop3h 54m
Sat 10/316:00 am -
1 stop4h 28m
Deal found 9/16![Delta logo]()
$273
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:05 am -
2 stops5h 25m
Tue 11/37:55 am -
1 stop4h 25m
Deal found 9/17![Southwest logo]()
$224
One-way flights from Detroit to Panama CitySearch for one-way flight options from Detroit to Panama City. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
Search for one-way flight options from Detroit to Panama City. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:20 pm -
1 stop4h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Delta logo]()
$127
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:20 am -
1 stop3h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Delta logo]()
$146
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:42 pm -
1 stop5h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![American Airlines logo]()
$181
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:20 am -
1 stop4h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Delta logo]()
$185
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/277:43 pm -
1 stop5h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![American Airlines logo]()
$212
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/11:30 pm -
2 stops9h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$224
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:26 am -
2 stops9h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![United Airlines logo]()
$227
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/712:30 pm -
2 stops10h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![United Airlines logo]()
$228
Find flight deals from Detroit to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTT) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $212 (Southwest) |
One-way from | $127 (Delta) |
Popular in | May |
Cheapest in | January |
Average price | $327 |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
Use the filters below to find and compare flights from Detroit to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Wed 10/14
5:20 am-8:14 am
1 stop3h 54m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$127
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Wed 10/7
4:20 pm-8:03 pm
1 stop4h 43m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$127
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Thu 11/26
2:48 pm-5:57 pm
1 stop4h 09m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$146
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Tue 11/3
6:00 am-3:35 pm
2 stops10h 35m
Panama City NW Florida Beaches
Tue 11/10
7:30 am-6:00 pm
2 stops9h 30m
$217
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Wed 10/7
1:49 pm-6:42 pm
1 stop5h 53m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$219
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Sun 11/1
1:30 pm-9:30 pm
2 stops9h 00m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$224
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Thu 11/26
7:26 am-4:18 pm
2 stops9h 52m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$227
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Tue 11/24
5:40 am-9:20 am
1 stop4h 40m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$252
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Tue 9/22
6:15 am-1:52 pm
1 stop8h 37m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$252
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Sat 10/10
7:50 pm-11:18 pm
1 stop4h 28m
Panama City NW Florida Beaches
Sat 10/17
7:12 am-1:06 pm
1 stop4h 54m
$306
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Detroit to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Panama City in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Detroit-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Detroit with our price prediction graph.
DTT-ECP
DTW-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Detroit to Panama City
DTT-ECP
DTW-ECP
What is the cheapest month to book a flight from Detroit to Panama City, Florida?
Currently, January is the cheapest month in which you can book a flight from Detroit to Panama City, Florida (average of $285). Flying from Detroit to Panama City, Florida in March is currently the most expensive (average of $703). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What’s the top layover airport for flights from Detroit to Panama City, Florida?
Share of 1-stop round-trip flights from Detroit to Panama City, Florida chosen by Cheapflights users in the past 12 months, using the same layover each way.
Charlotte (CLT) – chosen by Cheapflights users on 55% of 1-stop itineraries from Detroit to Panama City, Florida on Cheapflights.
What’s the cheapest layover airport for flights from Detroit to Panama City, Florida?
Average round-trip fare for 1-stop flights from Detroit to Panama City, Florida, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Charlotte (CLT) is the most affordable 1-stop option, with an average round-trip price of $314.
What’s the fastest layover option from Detroit to Panama City, Florida?
Shortest average travel time for 1-stop one-way flights from Detroit to Panama City, Florida, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Charlotte (CLT) have the shortest average one-way travel time for 1-stop routes: 4h 59m.
Which airport typically offers the quickest layover for flights from Detroit to Panama City, Florida?
Average layover duration for 1-stop one-way flights from Detroit to Panama City, Florida, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Charlotte (CLT) offer the fastest connection on this route, with an average layover time of 1h 12m.
How far ahead should I book a flight from Detroit to Panama City, Florida?
Booking 78 days in advance of your planned departure date is, on average, the best time to get cheap flights from Detroit to Panama City, Florida. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 18, 2026.
Read through reviews of airlines operating flights from Detroit to Panama City, such as Southwest,Delta, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Food
7.0
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Food
7.0
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Food
7.0
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
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Top 4 airlines flying from Detroit to Panama City
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$238 | Average$400 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$239 | Average$394 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$249 | Average$443 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$278 | Average$400 | FlexibilityNo cancel fee | On-time69% |