$157+ Cheap flights from Detroit to Panama City, FL (DTT - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — ECP
Sep 4 — Sep 111
Round-trip
1 adult, Economy
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Find cheap flights from Detroit to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to Panama City
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Cheapest flights from Detroit to Panama CityExplore the most affordable flight options available from Detroit to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 5, 2026.
Explore the most affordable flight options available from Detroit to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 5, 2026.
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/51:20 pm -
1 stop5h 50m
Sat 9/123:40 pm -
1 stop4h 50m
Deal found 8/4![Southwest logo]()
$313
This American Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/112:15 pm -
1 stop6h 01m
Tue 9/85:48 pm -
1 stop4h 44m
Deal found 8/4![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:43 pm -
1 stop4h 57m
Sat 8/295:48 pm -
1 stop4h 49m
Deal found 7/31![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/77:15 am -
1 stop4h 57m
Tue 9/151:32 pm -
1 stop7h 06m
Deal found 8/5![American Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:20 am -
1 stop6h 28m
Sun 9/66:00 am -
1 stop4h 15m
Deal found 8/2![Delta logo]()
$332
This United Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:30 am -
2 stops9h 43m
Thu 10/293:00 pm -
1 stop6h 27m
Deal found 8/4![United Airlines logo]()
$333
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/307:15 am -
1 stop7h 35m
Sun 9/62:20 pm -
1 stop7h 13m
Deal found 7/31![American Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/199:15 am -
1 stop4h 51m
Thu 8/271:47 pm -
1 stop7h 38m
Deal found 8/1![United Airlines logo]()
$338
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:20 am -
1 stop3h 54m
Sat 10/179:19 am -
1 stop6h 51m
Deal found 8/5![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:15 pm -
1 stop5h 25m
Sat 9/59:27 am -
1 stop5h 37m
Deal found 8/2![Delta logo]()
$340
Best flights from Detroit to Panama CityDiscover carefully curated flight deals from Detroit to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 5, 2026.
Discover carefully curated flight deals from Detroit to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 5, 2026.
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:00 am -
1 stop4h 28m
Sat 10/316:43 pm -
1 stop4h 52m
Deal found 7/31![American Airlines logo]()
$313
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
1 stop4h 00m
Tue 9/297:45 am -
1 stop4h 10m
Deal found 7/31![Southwest logo]()
$313
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2610:25 am -
1 stop5h 49m
Tue 9/292:08 pm -
1 stop5h 32m
Deal found 7/31![United Airlines logo]()
$313
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:40 pm -
1 stop6h 38m
Sat 10/179:19 am -
1 stop5h 35m
Deal found 8/3![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/612:35 pm -
2 stops8h 31m
Sat 1/96:30 am -
1 stop8h 13m
Deal found 8/4![United Airlines logo]()
$318
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:20 am -
1 stop3h 50m
Sat 10/316:10 am -
2 stops10h 20m
Deal found 7/31![Southwest logo]()
$341
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:10 am -
1 stop4h 30m
Sat 10/316:10 am -
2 stops8h 40m
Deal found 7/31![Southwest logo]()
$341
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:30 am -
1 stop6h 36m
Thu 8/272:27 pm -
1 stop7h 03m
Deal found 8/3![United Airlines logo]()
$351
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:55 am -
1 stop7h 50m
Thu 9/244:10 pm -
1 stop5h 30m
Deal found 8/2![Southwest logo]()
$348
Last-minute flights from Detroit to Panama CityDiscover last-minute flight deals from Detroit to Panama City. Data last updated August 5, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to Panama City. Data last updated August 5, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/199:15 am -
1 stop4h 51m
Thu 8/271:47 pm -
1 stop7h 38m
Deal found 8/1![United Airlines logo]()
$338
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:43 pm -
1 stop4h 57m
Sat 8/295:48 pm -
1 stop4h 49m
Deal found 7/31![American Airlines logo]()
$325
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:20 pm -
1 stop4h 20m
Sun 9/66:00 am -
1 stop4h 15m
Deal found 8/2![Delta logo]()
$340
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/307:15 am -
1 stop7h 35m
Sun 9/62:20 pm -
1 stop7h 13m
Deal found 7/31![American Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/309:15 am -
1 stop4h 51m
Sun 9/66:30 am -
2 stops9h 30m
Deal found 7/31![United Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/112:15 pm -
1 stop6h 01m
Tue 9/85:48 pm -
1 stop4h 44m
Deal found 8/4![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:20 am -
1 stop6h 28m
Sun 9/66:00 am -
1 stop4h 15m
Deal found 8/2![Delta logo]()
$332
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/51:20 pm -
1 stop5h 50m
Sat 9/123:40 pm -
1 stop4h 50m
Deal found 8/4![Southwest logo]()
$313
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/77:15 am -
1 stop4h 57m
Tue 9/151:32 pm -
1 stop7h 06m
Deal found 8/5![American Airlines logo]()
$328
One-way flights from Detroit to Panama CitySearch for one-way flight options from Detroit to Panama City. Find affordable one-way fares based on user searches. Data last updated August 5, 2026.
Search for one-way flight options from Detroit to Panama City. Find affordable one-way fares based on user searches. Data last updated August 5, 2026.
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:55 am -
1 stop7h 00m
Deal found 7/31![Southwest logo]()
$157
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:30 am -
2 stops11h 43m
Deal found 7/31![United Airlines logo]()
$162
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/319:15 am -
1 stop4h 51m
Deal found 8/3![United Airlines logo]()
$176
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:20 am -
1 stop6h 22m
Deal found 8/3![Delta logo]()
$178
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:30 am -
1 stop5h 02m
Deal found 8/3![American Airlines logo]()
$182
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:20 am -
1 stop3h 56m
Deal found 8/4![Delta logo]()
$185
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/142:40 pm -
2 stops5h 25m
Deal found 8/3![Southwest logo]()
$214
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:10 am -
2 stops10h 55m
Deal found 8/4![Southwest logo]()
$271
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/181:06 pm -
2 stops10h 34m
Deal found 8/3![American Airlines logo]()
$290
This Southwest deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2712:50 pm -
1 stop9h 00m
Deal found 8/1![Southwest logo]()
$310
Find flight deals from Detroit to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTT) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $313 (Southwest) |
One-way from | $157 (Southwest) |
Popular in | March |
Cheapest in | January |
Average price | $310 |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 5, 2026.
Use the filters below to find and compare flights from Detroit to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Sat 10/24
7:00 am-10:28 am
1 stop4h 28m
Panama City NW Florida Beaches
Sat 10/31
6:43 pm-12:35 am
1 stop4h 52m
$313
Quickest round-trip
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Sat 9/26
6:00 am-9:00 am
1 stop4h 00m
Panama City NW Florida Beaches
Tue 9/29
7:45 am-12:55 pm
1 stop4h 10m
$313
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Sat 9/26
10:25 am-3:14 pm
1 stop5h 49m
Panama City NW Florida Beaches
Tue 9/29
2:08 pm-8:40 pm
1 stop5h 32m
$313
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Wed 1/6
12:35 pm-8:06 pm
2 stops8h 31m
Panama City NW Florida Beaches
Sat 1/9
6:30 am-3:43 pm
1 stop8h 13m
$318
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Sat 10/10
5:40 pm-11:18 pm
1 stop6h 38m
Panama City NW Florida Beaches
Sat 10/17
9:19 am-3:54 pm
1 stop5h 35m
$339
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Sat 10/24
6:20 am-9:10 am
1 stop3h 50m
Panama City NW Florida Beaches
Sat 10/31
6:10 am-5:30 pm
2 stops10h 20m
$341
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Wed 10/28
6:10 am-9:40 am
1 stop4h 30m
Panama City NW Florida Beaches
Sat 10/31
6:10 am-3:50 pm
2 stops8h 40m
$341
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Fri 9/18
8:55 am-3:45 pm
1 stop7h 50m
Panama City NW Florida Beaches
Thu 9/24
4:10 pm-10:40 pm
1 stop5h 30m
$348
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Mon 8/24
7:30 am-1:06 pm
1 stop6h 36m
Panama City NW Florida Beaches
Thu 8/27
2:27 pm-10:30 pm
1 stop7h 03m
$351
Cheapest one-way
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Sat 12/5
8:15 am-2:17 pm
1 stop7h 02m
$157
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Detroit to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Panama City in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Detroit-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Detroit with our price prediction graph.
DTT-ECP
DTW-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Detroit to Panama City
DTT-ECP
DTW-ECP
What is the cheapest month to book a flight from Detroit to Panama City, Florida?
Currently, September is the cheapest month in which you can book a flight from Detroit to Panama City, Florida (average of $278). Flying from Detroit to Panama City, Florida in March is currently the most expensive (average of $691). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Detroit to Panama City, Florida?
Airfare is typical for this route at the moment.
Detroit to Panama City, Florida flights typically cost between $228 and $318 in September.The cheapest round-trip price found within the last 5 days was $313 on Southwest (Sep 5-Sep 12).
What’s the top layover airport for flights from Detroit to Panama City, Florida?
Share of 1-stop round-trip flights from Detroit to Panama City, Florida chosen by Cheapflights users in the past 12 months, using the same layover each way.
Nashville (BNA) – chosen by Cheapflights users on 56% of 1-stop itineraries from Detroit to Panama City, Florida on Cheapflights.
What’s the cheapest layover airport for flights from Detroit to Panama City, Florida?
Average round-trip fare for 1-stop flights from Detroit to Panama City, Florida, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Charlotte (CLT) is the most affordable 1-stop option, with an average round-trip price of $318.
What’s the fastest layover option from Detroit to Panama City, Florida?
Shortest average travel time for 1-stop one-way flights from Detroit to Panama City, Florida, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Charlotte (CLT) have the shortest average one-way travel time for 1-stop routes: 4h 35m.
Which airport typically offers the quickest layover for flights from Detroit to Panama City, Florida?
Average layover duration for 1-stop one-way flights from Detroit to Panama City, Florida, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Charlotte (CLT) offer the fastest connection on this route, with an average layover time of 1h 03m.
How far ahead should I book a flight from Detroit to Panama City, Florida?
Booking 75 days in advance of your planned departure date is, on average, the best time to get cheap flights from Detroit to Panama City, Florida. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated August 5, 2026.
Read through reviews of airlines operating flights from Detroit to Panama City, such as Southwest,Delta, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Related info for your journey
Find useful and relevant information for your journey from Detroit to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
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Alternative routes for Detroit to Panama City
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Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Detroit to Panama City by cabin class
Find flights from Detroit to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Detroit and Panama City flights
Browse other Detroit and Panama City flight options. Last updated on August 5, 2026.
Other flights from Detroit
Browse through other flights departing from Detroit. Flights are based on user searches made on Cheapflights and were last updated on August 5, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Detroit to Panama City flights
Consider these flights traveling from Detroit to Panama City.
Top 4 airlines flying from Detroit to Panama City
Discover the top 4 airlines that operate flights from Detroit to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$238 | Average$436 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$238 | Average$389 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$238 | Average$400 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$239 | Average$394 | FlexibilityNo cancel fee | On-time71% |