$163+ Cheap flights from Detroit Metropolitan Wayne County Airport to Panama City, FL (DTW - ECP)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — ECP
Oct 11 — Oct 181
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to Panama City
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Cheapest flights from Detroit to Panama CityExplore the most affordable flight options available from Detroit to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
Explore the most affordable flight options available from Detroit to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:49 pm -
1 stop5h 53m
Wed 11/45:41 pm -
1 stop4h 47m
Deal found 9/11![American Airlines logo]()
$312
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:50 pm -
1 stop4h 28m
Sat 10/176:00 am -
1 stop4h 30m
Deal found 9/10![Delta logo]()
$313
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:20 am -
1 stop3h 54m
Tue 10/205:34 pm -
1 stop6h 24m
Deal found 9/8![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:10 am -
1 stop5h 18m
Sat 10/176:42 pm -
1 stop4h 53m
Deal found 9/10![American Airlines logo]()
$328
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:15 am -
1 stop7h 54m
Sat 11/213:05 pm -
1 stop6h 22m
Deal found 9/8![United Airlines logo]()
$329
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:30 am -
2 stops9h 43m
Tue 10/62:50 pm -
1 stop6h 40m
Deal found 9/8![United Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:55 pm -
1 stop4h 58m
Thu 10/87:15 am -
1 stop4h 51m
Deal found 9/8![American Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:15 am -
2 stops11h 03m
Wed 11/119:06 am -
2 stops10h 24m
Deal found 9/8![United Airlines logo]()
$335
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:15 am -
1 stop8h 48m
Sat 10/246:20 am -
2 stops11h 00m
Deal found 9/7![United Airlines logo]()
$338
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:43 pm -
1 stop5h 04m
Sun 11/226:49 pm -
1 stop4h 45m
Deal found 9/8![American Airlines logo]()
$343
Best flights from Detroit to Panama CityDiscover carefully curated flight deals from Detroit to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
Discover carefully curated flight deals from Detroit to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:46 pm -
1 stop5h 32m
Tue 10/206:00 am -
1 stop4h 30m
Deal found 9/10![Delta logo]()
$313
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/310:25 am -
1 stop5h 49m
Tue 10/611:41 am -
2 stops11h 18m
Deal found 9/9![United Airlines logo]()
$330
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:25 pm -
1 stop4h 05m
Tue 10/611:30 am -
2 stops10h 05m
Deal found 9/11![Southwest logo]()
$400
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:20 pm -
1 stop4h 45m
Tue 10/69:19 am -
1 stop6h 58m
Deal found 9/9![Delta logo]()
$325
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/143:55 pm -
1 stop4h 41m
Sun 1/247:05 pm -
1 stop4h 39m
Deal found 9/8![Delta logo]()
$344
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/94:43 pm -
1 stop6h 00m
Wed 1/132:08 pm -
1 stop7h 19m
Deal found 9/10![United Airlines logo]()
$393
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/66:50 am -
2 stops8h 35m
Sun 12/137:55 am -
1 stop3h 50m
Deal found 9/6![Southwest logo]()
$404
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/163:55 pm -
1 stop4h 41m
Sun 2/217:05 pm -
1 stop4h 39m
Deal found 9/7![Delta logo]()
$348
Last-minute flights from Detroit to Panama CityDiscover last-minute flight deals from Detroit to Panama City. Data last updated September 11, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to Panama City. Data last updated September 11, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:30 am -
2 stops9h 43m
Tue 10/62:50 pm -
1 stop6h 40m
Deal found 9/8![United Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:55 pm -
1 stop4h 58m
Thu 10/87:15 am -
1 stop4h 51m
Deal found 9/8![American Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:50 pm -
1 stop4h 28m
Sat 10/176:00 am -
1 stop4h 30m
Deal found 9/10![Delta logo]()
$313
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:55 pm -
1 stop4h 58m
Sat 10/176:42 pm -
1 stop4h 53m
Deal found 9/11![American Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:10 am -
1 stop5h 18m
Sat 10/176:42 pm -
1 stop4h 53m
Deal found 9/10![American Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/117:25 am -
1 stop6h 25m
Wed 10/146:20 pm -
1 stop5h 38m
Deal found 9/8![Delta logo]()
$344
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:20 am -
1 stop3h 54m
Tue 10/205:34 pm -
1 stop6h 24m
Deal found 9/8![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:15 am -
1 stop8h 48m
Sat 10/246:20 am -
2 stops11h 00m
Deal found 9/7![United Airlines logo]()
$338
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:49 pm -
1 stop5h 53m
Wed 11/45:41 pm -
1 stop4h 47m
Deal found 9/11![American Airlines logo]()
$312
One-way flights from Detroit to Panama CitySearch for one-way flight options from Detroit to Panama City. Find affordable one-way fares based on user searches. Data last updated September 11, 2026.
Search for one-way flight options from Detroit to Panama City. Find affordable one-way fares based on user searches. Data last updated September 11, 2026.
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:20 am -
1 stop3h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Delta logo]()
$163
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/261:49 pm -
1 stop5h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![American Airlines logo]()
$171
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:26 am -
2 stops9h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![United Airlines logo]()
$224
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/262:45 pm -
2 stops7h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Southwest logo]()
$234
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:00 am -
1 stop4h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Southwest logo]()
$242
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2910:25 am -
2 stops12h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![United Airlines logo]()
$247
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:30 am -
2 stops9h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$283
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/711:11 am -
2 stops8h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$301
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/295:35 am -
1 stop9h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Southwest logo]()
$305
Find flight deals from Detroit to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTW) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $312 (American Airlines) |
One-way from | $163 (Delta) |
Popular in | March |
Cheapest in | January |
Average price | $318 |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Thu 11/26
2:48 pm-5:57 pm
1 stop4h 09m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$163
Quickest round-trip
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Wed 10/7
5:20 am-8:14 am
1 stop3h 54m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$163
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Wed 11/4
7:26 am-4:18 pm
2 stops9h 52m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$224
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Mon 10/26
2:45 pm-8:55 pm
2 stops7h 10m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$234
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Tue 9/29
10:25 am-10:18 pm
2 stops12h 53m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$247
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Wed 10/7
5:30 am-2:02 pm
2 stops9h 32m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$283
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Tue 10/13
6:46 pm-11:18 pm
1 stop5h 32m
Panama City NW Florida Beaches
Tue 10/20
6:00 am-11:30 am
1 stop4h 30m
$313
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Sat 10/3
7:20 pm-11:05 pm
1 stop4h 45m
Panama City NW Florida Beaches
Tue 10/6
9:19 am-5:17 pm
1 stop6h 58m
$325
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Sat 10/3
10:25 am-3:14 pm
1 stop5h 49m
Panama City NW Florida Beaches
Tue 10/6
11:41 am-11:59 pm
2 stops11h 18m
$330
DetroitPanama City
DTW Detroit Metropolitan Wayne County - ECP Panama City NW Florida Beaches
DTWECP
Detroit Metropolitan Wayne County
Thu 1/14
3:55 pm-7:36 pm
1 stop4h 41m
Panama City NW Florida Beaches
Sun 1/24
7:05 pm-12:44 am
1 stop4h 39m
$344
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Detroit to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Panama City in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit Metropolitan Wayne County Airport-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Detroit with our price prediction graph.
DTW-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to Panama City
Prices
More
How far ahead should I book a flight from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
The price you pay for your flight from Detroit Metropolitan Wayne County Airport to Panama City, Florida may vary depending on when you book. For the best chance of a lower fare, look to book 87 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Currently, January is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Panama City, Florida (average of $285). Flying from Detroit Metropolitan Wayne County Airport to Panama City, Florida in March is currently the most expensive (average of $776). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Airfare is typical for this route at the moment.
Detroit Metropolitan Wayne County Airport to Panama City, Florida flights typically cost between $266 and $327 in October.The cheapest round-trip price found within the last 5 days was $312 on American Airlines (Oct 31-Nov 4).
What’s the top layover airport for flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Share of 1-stop round-trip flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida chosen by Cheapflights users in the past 12 months, using the same layover each way.
Nashville (BNA) – chosen by Cheapflights users on 44% of 1-stop itineraries from Detroit Metropolitan Wayne County Airport to Panama City, Florida on Cheapflights.
What’s the cheapest layover airport for flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Average round-trip fare for 1-stop flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Charlotte (CLT) is the most affordable 1-stop option, with an average round-trip price of $314.
What’s the fastest layover option from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Shortest average travel time for 1-stop one-way flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Charlotte (CLT) have the shortest average one-way travel time for 1-stop routes: 4h 59m.
Which airport typically offers the quickest layover for flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Average layover duration for 1-stop one-way flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Charlotte (CLT) offer the fastest connection on this route, with an average layover time of 1h 12m.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 11, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Detroit Metropolitan Wayne County Airport to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Comfort
8.0
Overall
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Crew
8.6
Comfort
8.0
Overall
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Crew
8.6
Comfort
8.0
Overall
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Crew
8.6
Comfort
8.0
Overall
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Crew
8.6
Comfort
8.0
Overall
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Related info for your journey
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Detroit and Panama City flights
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Top 4 airlines flying from Detroit to Panama City
Discover the top 4 airlines that operate flights from Detroit to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$238 | Average$400 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$238 | Average$398 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$239 | Average$394 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$249 | Average$440 | FlexibilityNo cancel fee | On-time63% |