$158+ Cheap flights from Detroit Metropolitan Wayne County Airport to Panama City, FL (DTW - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — ECP
May 26 — Jun 21
Round-trip
1 adult, Economy
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Cheapest flights from Detroit to Panama CityExplore the most affordable flight options available from Detroit to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 26, 2026.
Explore the most affordable flight options available from Detroit to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 26, 2026.
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:00 am
DTW
- ECP
1 stop5h 03m
American Airlines
Wed 5/273:22 pm
ECP
- DTW
1 stop7h 20m
American Airlines
Deal found 4/22![American Airlines logo]()
$223
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:00 am
DTW
- ECP
1 stop5h 04m
American Airlines
Tue 6/167:05 am
ECP
- DTW
1 stop7h 23m
American Airlines
Deal found 4/23![American Airlines logo]()
$265
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:49 pm
DTW
- ECP
1 stop4h 57m
American Airlines
Sat 5/236:45 pm
ECP
- DTW
1 stop4h 48m
American Airlines
Deal found 4/22![American Airlines logo]()
$266
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/201:40 pm
DTW
- ECP
2 stops6h 15m
Southwest
Wed 5/277:15 am
ECP
- DTW
1 stop4h 25m
Southwest
Deal found 4/21![Southwest logo]()
$286
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:50 am
DTW
- ECP
1 stop4h 49m
United Airlines
Wed 9/210:25 am
ECP
- DTW
1 stop6h 54m
United Airlines
Deal found 4/22![United Airlines logo]()
$291
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:23 pm
DTW
- ECP
2 stops8h 17m
American Airlines
Thu 5/2811:00 am
ECP
- DTW
2 stops8h 25m
American Airlines
Deal found 4/21![American Airlines logo]()
$292
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:49 pm
DTW
- ECP
1 stop4h 57m
American Airlines
Tue 5/194:40 pm
ECP
- DTW
1 stop5h 52m
American Airlines
Deal found 4/21![American Airlines logo]()
$306
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/64:53 pm
DTW
- ECP
2 stops7h 47m
American Airlines
Sat 6/133:48 pm
ECP
- DTW
1 stop5h 37m
American Airlines
Deal found 4/22![American Airlines logo]()
$310
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/51:27 pm
DTW
- ECP
1 stop5h 46m
American Airlines
Mon 9/143:29 pm
ECP
- DTW
1 stop5h 33m
American Airlines
Deal found 4/22![American Airlines logo]()
$314
Best flights from Detroit to Panama CityDiscover carefully curated flight deals from Detroit to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 26, 2026.
Discover carefully curated flight deals from Detroit to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 26, 2026.
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/317:29 am
DTW
- ECP
1 stop6h 21m
Delta
Sat 6/65:29 pm
ECP
- DTW
1 stop6h 28m
Delta
Deal found 4/21![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:30 am
DTW
- ECP
1 stop4h 05m
Southwest
Sun 7/267:20 am
ECP
- DTW
1 stop5h 40m
Southwest
Deal found 4/23![Southwest logo]()
$417
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:45 pm
DTW
- ECP
1 stop4h 16m
Delta
Tue 6/21:50 pm
ECP
- DTW
1 stop4h 05m
Delta
Deal found 4/25![Delta logo]()
$319
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/155:20 am
DTW
- ECP
1 stop4h 00m
Delta
Wed 7/226:00 am
ECP
- DTW
1 stop4h 10m
Delta
Deal found 4/24![Delta logo]()
$319
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:17 am
DTW
- ECP
1 stop5h 37m
Delta
Tue 6/165:08 pm
ECP
- DTW
1 stop4h 46m
Delta
Deal found 4/26![Delta logo]()
$319
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:38 pm
DTW
- ECP
1 stop6h 06m
Delta
Mon 7/66:41 pm
ECP
- DTW
1 stop4h 17m
Delta
Deal found 4/24![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/138:15 am
DTW
- ECP
2 stops9h 05m
Southwest
Sat 5/1612:40 pm
ECP
- DTW
1 stop7h 45m
Southwest
Deal found 4/23![Southwest logo]()
$429
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/135:25 pm
DTW
- ECP
1 stop4h 25m
Southwest
Sat 6/2010:30 am
ECP
- DTW
2 stops8h 35m
Southwest
Deal found 4/21![Southwest logo]()
$454
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/163:40 pm
DTW
- ECP
1 stop4h 20m
Southwest
Thu 5/219:55 am
ECP
- DTW
2 stops10h 15m
Southwest
Deal found 4/22![Southwest logo]()
$459
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1810:45 am
DTW
- ECP
2 stops7h 30m
Southwest
Mon 6/226:20 pm
ECP
- DTW
1 stop4h 45m
Southwest
Deal found 4/21![Southwest logo]()
$463
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:20 am
DTW
- ECP
1 stop4h 10m
Delta
Sun 6/141:31 pm
ECP
- DTW
1 stop8h 25m
Delta
Deal found 4/24![Delta logo]()
$458
Last-minute flights from Detroit to Panama CityDiscover last-minute flight deals from Detroit to Panama City. Data last updated April 26, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to Panama City. Data last updated April 26, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:50 pm
DTW
- ECP
2 stops9h 02m
American Airlines
Thu 5/1410:50 am
ECP
- DTW
2 stops9h 31m
American Airlines
Deal found 4/21![American Airlines logo]()
$291
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/123:42 pm
DTW
- ECP
1 stop7h 38m
American Airlines
Wed 5/134:40 pm
ECP
- DTW
1 stop4h 48m
American Airlines
Deal found 4/21![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:49 pm
DTW
- ECP
1 stop4h 57m
American Airlines
Tue 5/194:40 pm
ECP
- DTW
1 stop5h 52m
American Airlines
Deal found 4/21![American Airlines logo]()
$306
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:49 pm
DTW
- ECP
1 stop4h 57m
American Airlines
Sat 5/236:45 pm
ECP
- DTW
1 stop4h 48m
American Airlines
Deal found 4/22![American Airlines logo]()
$266
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:49 pm
DTW
- ECP
1 stop4h 57m
American Airlines
Thu 5/213:14 pm
ECP
- DTW
1 stop7h 23m
American Airlines
Deal found 4/22![American Airlines logo]()
$320
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/194:31 pm
DTW
- ECP
1 stop7h 21m
American Airlines
Tue 5/266:45 pm
ECP
- DTW
1 stop4h 48m
American Airlines
Deal found 4/21![American Airlines logo]()
$327
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:00 am
DTW
- ECP
1 stop5h 03m
American Airlines
Wed 5/273:22 pm
ECP
- DTW
1 stop7h 20m
American Airlines
Deal found 4/22![American Airlines logo]()
$223
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/201:40 pm
DTW
- ECP
2 stops6h 15m
Southwest
Wed 5/277:15 am
ECP
- DTW
1 stop4h 25m
Southwest
Deal found 4/21![Southwest logo]()
$286
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:23 pm
DTW
- ECP
2 stops8h 17m
American Airlines
Thu 5/2811:00 am
ECP
- DTW
2 stops8h 25m
American Airlines
Deal found 4/21![American Airlines logo]()
$292
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:45 pm
DTW
- ECP
1 stop4h 16m
Delta
Tue 6/21:50 pm
ECP
- DTW
1 stop4h 05m
Delta
Deal found 4/25![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:58 pm
DTW
- ECP
1 stop4h 42m
American Airlines
Tue 6/27:05 am
ECP
- DTW
2 stops7h 35m
American Airlines
Deal found 4/25![American Airlines logo]()
$324
One-way flights from Detroit to Panama CitySearch for one-way flight options from Detroit to Panama City. Find affordable one-way fares based on user searches. Data last updated April 26, 2026.
Search for one-way flight options from Detroit to Panama City. Find affordable one-way fares based on user searches. Data last updated April 26, 2026.
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:15 am
DTW
- ECP
1 stop7h 02m
United Airlines
Deal found 4/23![United Airlines logo]()
$158
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/231:43 pm
DTW
- ECP
1 stop5h 43m
American Airlines
Deal found 4/25![American Airlines logo]()
$160
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:55 am
DTW
- ECP
2 stops11h 57m
American Airlines
Deal found 4/23![American Airlines logo]()
$163
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/2310:13 am
DTW
- ECP
2 stops10h 48m
United Airlines
Deal found 4/24![United Airlines logo]()
$165
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:05 am
DTW
- ECP
1 stop7h 16m
United Airlines
Deal found 4/23![United Airlines logo]()
$166
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:58 pm
DTW
- ECP
1 stop4h 42m
American Airlines
Deal found 4/22![American Airlines logo]()
$171
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:22 am
DTW
- ECP
1 stop8h 01m
American Airlines
Deal found 4/23![American Airlines logo]()
$180
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/189:00 am
DTW
- ECP
1 stop5h 18m
United Airlines
Deal found 4/22![United Airlines logo]()
$181
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/241:25 pm
DTW
- ECP
2 stops8h 45m
Southwest
Deal found 4/26![Southwest logo]()
$185
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:00 am
DTW
- ECP
2 stops7h 48m
American Airlines
Deal found 4/22![American Airlines logo]()
$191
Find flight deals from Detroit to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTW) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $223 (American Airlines) |
One-way from | $158 (United Airlines) |
Popular in | March |
Cheapest in | September |
Average price | $359 |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 26, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Sun 5/31
7:29 am-12:50 pm
1 stop6h 21m
Panama City NW Florida Beaches
Sat 6/6
5:29 pm-12:57 am
1 stop6h 28m
$319
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Wed 5/27
7:45 pm-11:01 pm
1 stop4h 16m
Panama City NW Florida Beaches
Tue 6/2
1:50 pm-6:55 pm
1 stop4h 05m
$319
Quickest round-trip
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Wed 7/15
5:20 am-8:20 am
1 stop4h 00m
Panama City NW Florida Beaches
Wed 7/22
6:00 am-11:10 am
1 stop4h 10m
$319
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Tue 6/9
6:17 am-10:54 am
1 stop5h 37m
Panama City NW Florida Beaches
Tue 6/16
5:08 pm-10:54 pm
1 stop4h 46m
$319
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Fri 7/3
6:38 pm-11:44 pm
1 stop6h 06m
Panama City NW Florida Beaches
Mon 7/6
6:41 pm-11:58 pm
1 stop4h 17m
$319
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Thu 7/23
6:30 am-9:35 am
1 stop4h 05m
Panama City NW Florida Beaches
Sun 7/26
7:20 am-2:00 pm
1 stop5h 40m
$417
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Wed 5/13
8:15 am-4:20 pm
2 stops9h 05m
Panama City NW Florida Beaches
Sat 5/16
12:40 pm-9:25 pm
1 stop7h 45m
$429
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Sat 6/13
5:25 pm-8:50 pm
1 stop4h 25m
Panama City NW Florida Beaches
Sat 6/20
10:30 am-8:05 pm
2 stops8h 35m
$454
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Sat 6/6
5:20 am-8:30 am
1 stop4h 10m
Panama City NW Florida Beaches
Sun 6/14
1:31 pm-10:56 pm
1 stop8h 25m
$458
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Sat 5/16
3:40 pm-7:00 pm
1 stop4h 20m
Panama City NW Florida Beaches
Thu 5/21
9:55 am-9:10 pm
2 stops10h 15m
$459
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Detroit to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Panama City in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit Metropolitan Wayne County Airport-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Detroit with our price prediction graph.
DTW-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to Panama City
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How far ahead should I book a flight from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
The price you pay for your flight from Detroit Metropolitan Wayne County Airport to Panama City, Florida may vary depending on when you book. For the best chance of a lower fare, look to book 11 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Currently, September is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Panama City, Florida (average of $262). Flying from Detroit Metropolitan Wayne County Airport to Panama City, Florida in March is currently the most expensive (average of $494). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
What’s the top layover airport for flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Share of 1-stop round-trip flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida chosen by Cheapflights users in the past 12 months, using the same layover each way.
Nashville (BNA) – chosen by Cheapflights users on 67% of 1-stop itineraries from Detroit Metropolitan Wayne County Airport to Panama City, Florida on Cheapflights.
What’s the cheapest layover airport for flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Average round-trip fare for 1-stop flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Nashville (BNA) is the most affordable 1-stop option, with an average round-trip price of $324.
What’s the fastest layover option from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Shortest average travel time for 1-stop one-way flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Nashville (BNA) have the shortest average one-way travel time for 1-stop routes: 5h 24m.
Which airport typically offers the quickest layover for flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Average layover duration for 1-stop one-way flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Nashville (BNA) offer the fastest connection on this route, with an average layover time of 2h 20m.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated April 26, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Detroit Metropolitan Wayne County Airport to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Detroit to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
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Detroit and Panama City flights
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Top 4 airlines flying from Detroit to Panama City
Discover the top 4 airlines that operate flights from Detroit to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$196 | Average$319 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$228 | Average$382 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$237 | Average$337 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$238 | Average$400 | FlexibilityNo cancel fee | On-time69% |