$163+ Cheap flights from Detroit Metropolitan Wayne County Airport to Panama City, FL (DTW - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/17. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — ECP
Aug 27 — Sep 31
Round-trip
1 adult, Economy
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Find cheap flights from Detroit to Panama City with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to Panama City
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Cheapest flights from Detroit to Panama CityExplore the most affordable flight options available from Detroit to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2026.
Explore the most affordable flight options available from Detroit to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2026.
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:43 pm
DTW
- ECP
1 stop4h 57m
American Airlines
Mon 8/245:48 pm
ECP
- DTW
1 stop4h 44m
American Airlines
Deal found 7/23![American Airlines logo]()
$303
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:00 am
DTW
- ECP
1 stop4h 40m
Southwest
Sat 8/291:40 pm
ECP
- DTW
1 stop4h 15m
Southwest
Deal found 7/26![Southwest logo]()
$313
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2912:01 pm
DTW
- ECP
1 stop6h 15m
American Airlines
Mon 8/315:48 pm
ECP
- DTW
1 stop4h 44m
American Airlines
Deal found 7/26![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:30 am
DTW
- ECP
1 stop6h 36m
United Airlines
Wed 8/266:30 am
ECP
- DTW
2 stops12h 59m
United Airlines
Deal found 7/26![United Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1611:01 am
DTW
- ECP
1 stop7h 31m
American Airlines
Sun 9/206:43 pm
ECP
- DTW
1 stop4h 43m
American Airlines
Deal found 7/24![American Airlines logo]()
$328
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/21:30 pm
DTW
- ECP
2 stops8h 00m
Southwest
Thu 11/127:55 am
ECP
- DTW
1 stop3h 50m
Southwest
Deal found 7/27![Southwest logo]()
$330
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:45 am
DTW
- ECP
2 stops7h 55m
Southwest
Sun 9/62:10 pm
ECP
- DTW
1 stop5h 25m
Southwest
Deal found 7/26![Southwest logo]()
$331
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:50 am
DTW
- ECP
2 stops8h 35m
Southwest
Tue 12/158:00 am
ECP
- DTW
1 stop4h 15m
Southwest
Deal found 7/24![Southwest logo]()
$333
Best flights from Detroit to Panama CityDiscover carefully curated flight deals from Detroit to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 28, 2026.
Discover carefully curated flight deals from Detroit to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 28, 2026.
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:30 am
DTW
- ECP
1 stop6h 36m
United Airlines
Wed 8/266:30 am
ECP
- DTW
2 stops12h 59m
United Airlines
Deal found 7/26![United Airlines logo]()
$324
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/21:30 pm
DTW
- ECP
2 stops8h 00m
Southwest
Thu 11/127:55 am
ECP
- DTW
1 stop3h 50m
Southwest
Deal found 7/27![Southwest logo]()
$330
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:45 am
DTW
- ECP
2 stops7h 55m
Southwest
Sun 9/62:10 pm
ECP
- DTW
1 stop5h 25m
Southwest
Deal found 7/26![Southwest logo]()
$331
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:30 am
DTW
- ECP
2 stops6h 35m
Southwest
Tue 9/299:10 am
ECP
- DTW
2 stops10h 25m
Southwest
Deal found 7/27![Southwest logo]()
$336
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/297:34 am
DTW
- ECP
1 stop6h 32m
United Airlines
Tue 9/11:47 pm
ECP
- DTW
1 stop7h 38m
United Airlines
Deal found 7/27![United Airlines logo]()
$393
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/98:45 am
DTW
- ECP
2 stops7h 55m
Southwest
Mon 9/146:00 am
ECP
- DTW
2 stops11h 35m
Southwest
Deal found 7/23![Southwest logo]()
$358
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:25 am
DTW
- ECP
1 stop10h 15m
Southwest
Mon 9/211:30 pm
ECP
- DTW
1 stop4h 05m
Southwest
Deal found 7/26![Southwest logo]()
$372
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:10 am
DTW
- ECP
2 stops10h 55m
Southwest
Tue 9/299:10 am
ECP
- DTW
2 stops10h 25m
Southwest
Deal found 7/26![Southwest logo]()
$394
Last-minute flights from Detroit to Panama CityDiscover last-minute flight deals from Detroit to Panama City. Data last updated July 28, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to Panama City. Data last updated July 28, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:30 am
DTW
- ECP
1 stop6h 36m
United Airlines
Wed 8/266:30 am
ECP
- DTW
2 stops12h 59m
United Airlines
Deal found 7/26![United Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:43 pm
DTW
- ECP
1 stop4h 57m
American Airlines
Mon 8/245:48 pm
ECP
- DTW
1 stop4h 44m
American Airlines
Deal found 7/23![American Airlines logo]()
$303
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2112:15 pm
DTW
- ECP
1 stop6h 01m
American Airlines
Tue 8/256:40 am
ECP
- DTW
1 stop6h 30m
American Airlines
Deal found 7/26![American Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:00 am
DTW
- ECP
1 stop4h 40m
Southwest
Sat 8/291:40 pm
ECP
- DTW
1 stop4h 15m
Southwest
Deal found 7/26![Southwest logo]()
$313
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2812:15 pm
DTW
- ECP
1 stop6h 01m
American Airlines
Mon 8/315:48 pm
ECP
- DTW
1 stop4h 44m
American Airlines
Deal found 7/26![American Airlines logo]()
$334
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:40 pm
DTW
- ECP
2 stops5h 20m
Southwest
Mon 8/317:05 am
ECP
- DTW
1 stop4h 30m
Southwest
Deal found 7/26![Southwest logo]()
$339
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2912:01 pm
DTW
- ECP
1 stop6h 15m
American Airlines
Mon 8/315:48 pm
ECP
- DTW
1 stop4h 44m
American Airlines
Deal found 7/26![American Airlines logo]()
$319
One-way flights from Detroit to Panama CitySearch for one-way flight options from Detroit to Panama City. Find affordable one-way fares based on user searches. Data last updated July 28, 2026.
Search for one-way flight options from Detroit to Panama City. Find affordable one-way fares based on user searches. Data last updated July 28, 2026.
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:00 am
DTW
- ECP
1 stop6h 12m
American Airlines
Deal found 7/26![American Airlines logo]()
$163
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:00 am
DTW
- ECP
2 stops8h 06m
United Airlines
Deal found 7/27![United Airlines logo]()
$168
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:15 am
DTW
- ECP
1 stop5h 49m
United Airlines
Deal found 7/24![United Airlines logo]()
$181
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:55 am
DTW
- ECP
2 stops10h 50m
Southwest
Deal found 7/24![Southwest logo]()
$214
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:00 am
DTW
- ECP
1 stop4h 40m
Southwest
Deal found 7/25![Southwest logo]()
$242
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:15 am
DTW
- ECP
1 stop8h 37m
United Airlines
Deal found 7/27![United Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:55 am
DTW
- ECP
2 stops10h 50m
Southwest
Deal found 7/26![Southwest logo]()
$254
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/35:30 am
DTW
- ECP
1 stop5h 14m
United Airlines
Deal found 7/25![United Airlines logo]()
$286
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/71:20 pm
DTW
- ECP
2 stops6h 40m
Southwest
Deal found 7/26![Southwest logo]()
$291
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/35:50 am
DTW
- ECP
2 stops9h 25m
Southwest
Deal found 7/25![Southwest logo]()
$332
Find flight deals from Detroit to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTW) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $303 (American Airlines) |
One-way from | $163 (American Airlines) |
Popular in | March |
Cheapest in | September |
Average price | $443 |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Wed 8/19
7:30 am-1:06 pm
1 stop6h 36m
Panama City NW Florida Beaches
Wed 8/26
6:30 am-8:29 pm
2 stops12h 59m
$324
Quickest round-trip
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Mon 11/2
1:30 pm-8:30 pm
2 stops8h 00m
Panama City NW Florida Beaches
Thu 11/12
7:55 am-12:45 pm
1 stop3h 50m
$330
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Wed 9/2
8:45 am-3:40 pm
2 stops7h 55m
Panama City NW Florida Beaches
Sun 9/6
2:10 pm-8:35 pm
1 stop5h 25m
$331
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Sat 9/26
8:30 am-2:05 pm
2 stops6h 35m
Panama City NW Florida Beaches
Tue 9/29
9:10 am-8:35 pm
2 stops10h 25m
$336
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Wed 9/9
8:45 am-3:40 pm
2 stops7h 55m
Panama City NW Florida Beaches
Mon 9/14
6:00 am-6:35 pm
2 stops11h 35m
$358
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Wed 9/16
6:25 am-3:40 pm
1 stop10h 15m
Panama City NW Florida Beaches
Mon 9/21
1:30 pm-6:35 pm
1 stop4h 05m
$372
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Sat 8/29
7:34 am-1:06 pm
1 stop6h 32m
Panama City NW Florida Beaches
Tue 9/1
1:47 pm-10:25 pm
1 stop7h 38m
$393
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Thu 9/24
11:10 am-9:05 pm
2 stops10h 55m
Panama City NW Florida Beaches
Tue 9/29
9:10 am-8:35 pm
2 stops10h 25m
$394
Cheapest one-way
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Mon 8/17
6:00 am-1:06 pm
2 stops8h 06m
$168
DetroitPanama City
DTW - ECP
DTWECP
Detroit Metropolitan Wayne County
Mon 9/14
6:15 am-11:04 am
1 stop5h 49m
$181
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Detroit to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Panama City in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit Metropolitan Wayne County Airport-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Detroit with our price prediction graph.
DTW-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to Panama City
Prices
More
How far ahead should I book a flight from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
The price you pay for your flight from Detroit Metropolitan Wayne County Airport to Panama City, Florida may vary depending on when you book. For the best chance of a lower fare, look to book 29 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Currently, September is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Panama City, Florida (average of $278). Flying from Detroit Metropolitan Wayne County Airport to Panama City, Florida in March is currently the most expensive (average of $694). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Airfare is typical for this route at the moment.
Detroit Metropolitan Wayne County Airport to Panama City, Florida flights typically cost between $259 and $446 in August.The cheapest round-trip price found within the last 5 days was $303 on American Airlines (Aug 20-Aug 24).
What’s the top layover airport for flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Share of 1-stop round-trip flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida chosen by Cheapflights users in the past 12 months, using the same layover each way.
Nashville (BNA) – chosen by Cheapflights users on 71% of 1-stop itineraries from Detroit Metropolitan Wayne County Airport to Panama City, Florida on Cheapflights.
What’s the cheapest layover airport for flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Average round-trip fare for 1-stop flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Charlotte (CLT) is the most affordable 1-stop option, with an average round-trip price of $318.
What’s the fastest layover option from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Shortest average travel time for 1-stop one-way flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Charlotte (CLT) have the shortest average one-way travel time for 1-stop routes: 4h 35m.
Which airport typically offers the quickest layover for flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida?
Average layover duration for 1-stop one-way flights from Detroit Metropolitan Wayne County Airport to Panama City, Florida, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Charlotte (CLT) offer the fastest connection on this route, with an average layover time of 1h 03m.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated July 28, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Detroit Metropolitan Wayne County Airport to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Overall
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Comfort
8.0
Overall
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Comfort
8.0
Overall
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Comfort
8.0
Overall
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Comfort
8.0
Overall
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
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Find useful and relevant information for your journey from Detroit to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Detroit and Panama City flights
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Top 4 airlines flying from Detroit to Panama City
Discover the top 4 airlines that operate flights from Detroit to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$208 | Average$388 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$238 | Average$431 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$238 | Average$400 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$239 | Average$391 | FlexibilityNo cancel fee | On-time71% |