$116+ Cheap flights from Panama City, FL to Detroit Metropolitan Wayne County Airport (ECP - DTW)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/21. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — DTW
Nov 26 — Dec 31
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Detroit with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Detroit
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Best
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Cheapest flights from Panama City to DetroitExplore the most affordable flight options available from Panama City to Detroit. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2026.
Explore the most affordable flight options available from Panama City to Detroit. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2026.
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/123:05 pm -
1 stop6h 22m
Wed 11/1810:59 am -
1 stop6h 19m
Deal found 10/22![United Airlines logo]()
$231
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:55 pm -
1 stop4h 00m
Wed 11/186:00 am -
2 stops10h 35m
Deal found 10/21![Southwest logo]()
$236
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:30 am -
2 stops9h 30m
Thu 12/106:55 am -
2 stops9h 15m
Deal found 10/23![Southwest logo]()
$241
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:35 pm -
1 stop4h 05m
Mon 11/95:50 am -
1 stop4h 45m
Deal found 10/23![Southwest logo]()
$307
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:30 am -
2 stops9h 30m
Wed 12/96:55 am -
2 stops9h 15m
Deal found 10/23![Southwest logo]()
$317
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:25 am -
1 stop4h 30m
Fri 11/276:00 am -
1 stop5h 39m
Deal found 10/26![American Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:50 am -
2 stops8h 40m
Thu 11/198:50 am -
2 stops10h 25m
Deal found 10/23![Southwest logo]()
$370
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:41 pm -
1 stop4h 47m
Sat 11/145:52 am -
1 stop6h 32m
Deal found 10/26![American Airlines logo]()
$383
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:50 pm -
1 stop5h 40m
Wed 11/117:26 am -
2 stops9h 52m
Deal found 10/23![United Airlines logo]()
$388
Best flights from Panama City to DetroitDiscover carefully curated flight deals from Panama City to Detroit that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 27, 2026.
Discover carefully curated flight deals from Panama City to Detroit that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 27, 2026.
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/123:05 pm -
1 stop6h 22m
Wed 11/1810:59 am -
1 stop6h 19m
Deal found 10/22![United Airlines logo]()
$231
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:55 pm -
1 stop4h 00m
Wed 11/186:00 am -
2 stops10h 35m
Deal found 10/21![Southwest logo]()
$236
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:25 am -
1 stop4h 30m
Fri 11/276:00 am -
1 stop5h 39m
Deal found 10/26![American Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:50 am -
2 stops8h 40m
Mon 11/95:50 am -
1 stop4h 45m
Deal found 10/23![Southwest logo]()
$312
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:30 am -
2 stops9h 30m
Wed 12/96:55 am -
2 stops9h 15m
Deal found 10/23![Southwest logo]()
$317
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:41 pm -
1 stop4h 47m
Sat 11/145:52 am -
1 stop6h 32m
Deal found 10/26![American Airlines logo]()
$383
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:06 am -
2 stops10h 24m
Wed 11/116:15 am -
2 stops11h 03m
Deal found 10/23![United Airlines logo]()
$393
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:10 am -
1 stop4h 43m
Wed 11/184:05 pm -
2 stops7h 47m
Deal found 10/22![American Airlines logo]()
$393
Last-minute flights from Panama City to DetroitDiscover last-minute flight deals from Panama City to Detroit. Data last updated October 27, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Detroit. Data last updated October 27, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:35 pm -
1 stop4h 05m
Mon 11/95:50 am -
1 stop4h 45m
Deal found 10/23![Southwest logo]()
$307
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:50 pm -
1 stop5h 40m
Wed 11/117:26 am -
2 stops9h 52m
Deal found 10/23![United Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:41 pm -
1 stop4h 47m
Sat 11/145:52 am -
1 stop6h 32m
Deal found 10/26![American Airlines logo]()
$383
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/123:05 pm -
1 stop6h 22m
Wed 11/1810:59 am -
1 stop6h 19m
Deal found 10/22![United Airlines logo]()
$231
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:55 pm -
1 stop4h 00m
Wed 11/186:00 am -
2 stops10h 35m
Deal found 10/21![Southwest logo]()
$236
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:50 am -
2 stops8h 40m
Thu 11/198:50 am -
2 stops10h 25m
Deal found 10/23![Southwest logo]()
$370
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:25 am -
1 stop4h 30m
Fri 11/276:00 am -
1 stop5h 39m
Deal found 10/26![American Airlines logo]()
$339
One-way flights from Panama City to DetroitSearch for one-way flight options from Panama City to Detroit. Find affordable one-way fares based on user searches. Data last updated October 27, 2026.
Search for one-way flight options from Panama City to Detroit. Find affordable one-way fares based on user searches. Data last updated October 27, 2026.
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/216:25 pm -
1 stop4h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Southwest logo]()
$116
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:55 am -
1 stop4h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Southwest logo]()
$170
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/511:46 am -
1 stop6h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![American Airlines logo]()
$177
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/291:59 pm -
1 stop7h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Delta logo]()
$188
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/34:06 pm -
1 stop6h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Delta logo]()
$190
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/39:05 am -
2 stops12h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![United Airlines logo]()
$225
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:49 pm -
1 stop4h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![American Airlines logo]()
$229
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:55 am -
1 stop4h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Southwest logo]()
$262
Find flight deals from Panama City to Detroit
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Detroit (DTW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $231 (United Airlines) |
One-way from | $116 (Southwest) |
Popular in | November |
Cheapest in | January |
Average price | $350 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Detroit that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 27, 2026.
Use the filters below to find and compare flights from Panama City to Detroit Metropolitan Wayne County Airport that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityDetroit
ECP Panama City NW Florida Beaches - DTW Detroit Metropolitan Wayne County
ECPDTW
Panama City NW Florida Beaches
Mon 12/21
11:10 am-12:15 am
2 stops12h 05m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$127
Quickest round-trip
Panama CityDetroit
ECP Panama City NW Florida Beaches - DTW Detroit Metropolitan Wayne County
ECPDTW
Panama City NW Florida Beaches
Fri 12/4
7:55 am-1:20 pm
1 stop4h 25m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$170
Panama CityDetroit
ECP Panama City NW Florida Beaches - DTW Detroit Metropolitan Wayne County
ECPDTW
Panama City NW Florida Beaches
Sat 12/5
11:46 am-7:23 pm
1 stop6h 37m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$177
Panama CityDetroit
ECP Panama City NW Florida Beaches - DTW Detroit Metropolitan Wayne County
ECPDTW
Panama City NW Florida Beaches
Thu 12/3
4:06 pm-11:58 pm
1 stop6h 52m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$190
Panama CityDetroit
ECP Panama City NW Florida Beaches - DTW Detroit Metropolitan Wayne County
ECPDTW
Panama City NW Florida Beaches
Sat 12/5
1:30 pm-11:44 pm
2 stops9h 14m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$225
Panama CityDetroit
ECP Panama City NW Florida Beaches - DTW Detroit Metropolitan Wayne County
ECPDTW
Panama City NW Florida Beaches
Thu 11/12
3:05 pm-10:27 pm
1 stop6h 22m
Detroit Metropolitan Wayne County
Wed 11/18
10:59 am-4:18 pm
1 stop6h 19m
$231
Panama CityDetroit
ECP Panama City NW Florida Beaches - DTW Detroit Metropolitan Wayne County
ECPDTW
Panama City NW Florida Beaches
Thu 11/12
5:55 pm-10:55 pm
1 stop4h 00m
Detroit Metropolitan Wayne County
Wed 11/18
6:00 am-3:35 pm
2 stops10h 35m
$236
Panama CityDetroit
ECP Panama City NW Florida Beaches - DTW Detroit Metropolitan Wayne County
ECPDTW
Panama City NW Florida Beaches
Tue 12/29
1:59 pm-8:31 pm
1 stop5h 32m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$259
Panama CityDetroit
ECP Panama City NW Florida Beaches - DTW Detroit Metropolitan Wayne County
ECPDTW
Panama City NW Florida Beaches
Tue 11/3
7:55 am-1:20 pm
1 stop4h 25m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$262
Panama CityDetroit
ECP Panama City NW Florida Beaches - DTW Detroit Metropolitan Wayne County
ECPDTW
Panama City NW Florida Beaches
Sat 10/31
4:15 pm-10:15 pm
1 stop5h 00m
Detroit Metropolitan Wayne County
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$307
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Panama City to Detroit
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Detroit in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Detroit Metropolitan Wayne County Airport flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Detroit Metropolitan Wayne County Airport flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Detroit Metropolitan Wayne County Airport flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Detroit Metropolitan Wayne County Airport flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Detroit Metropolitan Wayne County Airport flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Detroit
Have a flexible travel schedule? Discover the best time to fly to Detroit from Panama City with our price prediction graph.
ECP-DTW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Detroit
Get insights into the airlines that provide service to Detroit. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Detroit. Reviews last updated October 27, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andAmerican Airlines from Panama City to Detroit Metropolitan Wayne County Airport to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Comfort
8.0
Entertainment
7.4
Overall
7.9
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Food
7.0
Comfort
8.0
Entertainment
7.4
Overall
7.9
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Food
7.0
Comfort
8.0
Entertainment
7.4
Overall
7.9
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Food
7.0
Comfort
8.0
Entertainment
7.4
Overall
7.9
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Related info for your journey
Find useful and relevant information for your journey from Panama City to Detroit. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Detroit Metropolitan Wayne County Airport?
Book flights to Detroit Metropolitan Wayne County Airport if you plan to visit one of these locationsDearborn
Sterling Heights
Southfield
Troy
Pontiac
Warren
Auburn Hills
Rochester Hills
Livonia
Southgate
Roseville
Romulus
Allen Park
Put-in-Bay
Ypsilanti
Plymouth
Fremont
Port Huron
Waterford
Utica
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
Complete your trip to Detroit by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Detroit
Explore flights to Detroit departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 27, 2026.
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Find flights from Panama City to Detroit, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama City and Detroit flights
Browse other Panama City and Detroit flight options. Last updated on October 27, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on October 27, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Panama City to Detroit
Discover the top 3 airlines that operate flights from Panama City to Detroit. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$238 | Average$528 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$238 | Average$389 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$297 | Average$360 | FlexibilityNo cancel fee | On-time71% |