HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Mesa

$79+ Cheap flights from Des Moines (DSM) to Mesa, AZ

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/20. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PHX
jul. 8 — jul. 151
mar. 7/8
mar. 7/15
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Mesa with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Des Moines to Mesa are usually found in January or November, booked 50 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from Des Moines to Mesa

Keep the following information in mind while searching for Des Moines to Mesa flight deals. Data was last updated julio 3, 2025.

Round-trip from

$201
(Priceline)

One-way from

$82
(Trip.com)

Popular in

March

Cheapest in

January

Average price

$332
From Des Moines to Mesa
Search Deals
One-way flight from Des Moines to Mesa
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($45 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Des Moines to Mesa

Cheapest flights from Des Moines to Mesa
Explore the most affordable flight options available from Des Moines to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 3, 2025.

This Priceline deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/217:33 pmDSM - PHX
1 stop5h 51mFrontier
lun. 7/289:32 amPHX - DSM
1 stop7h 16mFrontier
Deal found 7/1$201
This Southwest deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/306:25 amDSM - PHX
1 stop7h 45mSouthwest
mié. 8/61:00 pmPHX - DSM
1 stop7h 20mSouthwest
Deal found 7/2$216
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/225:23 pmDSM - PHX
1 stop7h 44mDelta
sáb. 7/266:40 amPHX - DSM
1 stop5h 35mDelta
Deal found 7/1$237
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/235:35 amDSM - PHX
Nonstop3h 02mAmerican Airlines
lun. 7/287:09 pmPHX - DSM
Nonstop2h 50mAmerican Airlines
Deal found 7/2$239
This Mytrip deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/157:30 amDSM - PHX
1 stop5h 47mMultiple Airlines
mié. 10/2212:12 pmPHX - DSM
3 stops31h 31mMultiple Airlines
Deal found 7/2$262

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 3, 2025.
Use the filters below to find and compare flights from Des Moines to Mesa that are best for you.

Fly from

Des Moines

Fly to

Mesa

Route

Depart

Return

Price

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

lun. 7/21

7:33 pm-11:24 pm

1 stop5h 51m

Phoenix Sky Harbor Intl

lun. 7/28

9:32 am-6:48 pm

1 stop7h 16m

$201

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

mié. 7/30

6:25 am-12:10 pm

1 stop7h 45m

Phoenix Sky Harbor Intl

mié. 8/6

1:00 pm-10:20 pm

1 stop7h 20m

$216

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

mar. 7/22

5:23 pm-11:07 pm

1 stop7h 44m

Phoenix Sky Harbor Intl

sáb. 7/26

6:40 am-2:15 pm

1 stop5h 35m

$237

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

mié. 7/23

5:35 am-6:37 am

Nonstop3h 02m

Phoenix Sky Harbor Intl

lun. 7/28

7:09 pm-11:59 pm

Nonstop2h 50m

$239

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

mié. 10/15

7:30 am-11:17 am

1 stop5h 47m

Phoenix Sky Harbor Intl

mié. 10/22

12:12 pm-9:43 pm

3 stops31h 31m

$262

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

lun. 10/20

4:35 pm-5:35 pm

Nonstop3h 00m

$79

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

lun. 9/8

2:25 pm-11:42 am

1 stop23h 17m

$82

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

dom. 8/3

10:31 pm-9:19 pm

1 stop24h 48m

$122

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

sáb. 8/30

3:30 pm-8:34 pm

1 stop7h 04m

$136

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

mar. 9/9

5:15 pm-12:15 am

2 stops9h 00m

$141

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/3

Showing 1-10 of 12 results
1
2

Best time to book a flight from Des Moines to Mesa

Have a flexible travel schedule? Discover the best time to fly to Mesa from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mesa

How far ahead should I book a flight from Des Moines to Mesa?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Mesa. Price data was last updated on June 27, 2025.

To ensure you get the cheapest price possible for a flight from Des Moines to Mesa, you should look to book at least 50 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Des Moines to Mesa?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Mesa (average of $258). Flying from Des Moines to Mesa in March is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to MS9?

Find hourly flight availability from Des Moines to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 3, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Mesa as you normally would.

What is the cheapest day to fly from Des Moines to Mesa?

Use this chart to determine the cheapest time to fly round-trip from Des Moines to Mesa. Price data was last updated on June 29, 2025.

Travelers seeking maximum savings on their Des Moines to Mesa flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Mesa

Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated julio 3, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to Mesa. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,266 reviews

Boarding

8.2

Entertainment

7.6

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,266 reviews
Southwest
8.0
Very good
4,266 reviews

Boarding

8.2

Entertainment

7.6

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,982 reviews
Southwest
8.0
Very good
4,266 reviews

Boarding

8.2

Entertainment

7.6

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,861 reviews
Southwest
8.0
Very good
4,266 reviews

Boarding

8.2

Entertainment

7.6

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Allegiant Air
7.3
Good
708 reviews
Southwest
8.0
Very good
4,266 reviews

Boarding

8.2

Entertainment

7.6

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,266 reviews

Boarding

8.2

Entertainment

7.6

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mesa?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Mesa from Des Moines. Booking flights from Des Moines (DSM) to Mesa should be relatively easy as there are 0 daily outbound flights to Mesa from 6 different airlines.

  • What are the cheapest airlines to fly from Des Moines to Mesa one-way?

    $82 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Southwest and Delta, with prices starting from $88 and $136, respectively.

  • What are the most reliable airlines from Des Moines to Mesa?

    Before booking your flight to Mesa from Des Moines, check out the most reliable airlines to get you to your destination on time: Alaska Airlines (86%), SkyWest Airlines (84%), American Airlines( 81%).

  • What are the cheapest flights from Des Moines to Mesa?

    Looking at all options, your cheapest flight can be booked for $94. While the most popular route (Des Moines - Phoenix Sky Harbor Intl) can be booked for $176 on average our data indicates $368 when flying from Des Moines to Mesa.

  • Can I find deals for flights from Des Moines to Mesa that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mesa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mesa.

  • Can I find deals for business class flights from Des Moines to Mesa?

    Yes. Cheapflights offers flight deals from Des Moines to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mesa?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Mesa (average of $258). Flying from Des Moines to Mesa in March is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Mesa

See prices for flight routes from nearby airports that may be better suited for you.
Omaha to Las Vegas flights
Des Moines to Las Vegas flights
Des Moines to Sky Harbor Intl flights
Cedar Rapids to Sky Harbor Intl flights
Omaha to Sky Harbor Intl flights
Cedar Rapids to Las Vegas flights
Moline to Las Vegas flights
Moline to Sky Harbor Intl flights
Cedar Rapids to Phoenix-Mesa Gateway flights
Des Moines to Phoenix-Mesa Gateway flights
Omaha to Tucson flights
Des Moines to Tucson flights
Omaha to Phoenix-Mesa Gateway flights
Moline to Tucson flights
Cedar Rapids to Tucson flights
Waterloo to Las Vegas flights
La Crosse to Las Vegas flights
Sioux City to Las Vegas flights
Fort Dodge to Las Vegas flights
La Crosse to Sky Harbor Intl flights
Waterloo to Sky Harbor Intl flights
Dubuque to Las Vegas flights
Des Moines to Flagstaff flights
Omaha to Flagstaff flights
Dubuque to Sky Harbor Intl flights
Cedar Rapids to Flagstaff flights
La Crosse to Tucson flights
Sioux City to Sky Harbor Intl flights
Dubuque to Tucson flights

Top 6 airlines flying from Des Moines to Mesa

Discover the top 6 airlines that operate flights from Des Moines to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$106Average$251FlexibilityNo cancel feeOn-time62%
Allegiant AirCheapest$117Average$223FlexibilityNo cancel feeOn-time88%
SouthwestCheapest$199Average$330FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$209Average$353FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$216Average$410FlexibilityNo cancel feeOn-time69%
DeltaCheapest$236Average$317FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.