$92+ Cheap flights from Des Moines (DSM) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PHX
Sep 7 — Sep 141
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to Mesa are usually found in October or January, booked 53 days in advance, depart on a Wednesday or Saturday and return on a Wednesday
Cheap flight deals from Des Moines to Mesa
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to MesaExplore the most affordable flight options available from Des Moines to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 8, 2026.
Explore the most affordable flight options available from Des Moines to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
1 stop16h 28m
Tue 9/298:39 pm -
1 stop15h 13m
Deal found 8/7![Multiple Airlines logo]()
$163
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
1 stop16h 28m
Tue 10/68:39 pm -
1 stop15h 13m
Deal found 8/5![Multiple Airlines logo]()
$169
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:38 pm -
1 stop18h 21m
Thu 8/2710:30 pm -
1 stop18h 18m
Deal found 8/5![Multiple Airlines logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
1 stop16h 28m
Thu 10/810:40 pm -
1 stop10h 17m
Deal found 8/5![Multiple Airlines logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:54 pm -
1 stop18h 05m
Thu 9/39:03 am -
1 stop24h 07m
Deal found 8/3![Multiple Airlines logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:50 pm -
1 stop16h 58m
Thu 8/2710:30 pm -
1 stop18h 18m
Deal found 8/3![Multiple Airlines logo]()
$192
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
1 stop16h 28m
Wed 9/308:39 pm -
1 stop20h 47m
Deal found 8/7![Multiple Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:42 pm -
1 stop23h 40m
Tue 10/68:39 pm -
1 stop15h 13m
Deal found 8/5![Multiple Airlines logo]()
$196
Best flights from Des Moines to MesaDiscover carefully curated flight deals from Des Moines to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 8, 2026.
Discover carefully curated flight deals from Des Moines to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 8, 2026.
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/12:00 pm -
Nonstop3h 05m
Mon 10/51:50 pm -
Nonstop2h 40m
Deal found 8/4![Southwest logo]()
$377
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:22 pm -
1 stop8h 15m
Sat 9/266:00 am -
1 stop4h 31m
Deal found 8/3![United Airlines logo]()
$397
This Delta deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1811:00 am -
1 stop7h 39m
Mon 11/236:00 am -
1 stop7h 13m
Deal found 8/8![Delta logo]()
$397
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:00 pm -
Nonstop3h 05m
Mon 10/261:50 pm -
Nonstop2h 40m
Deal found 8/5![Southwest logo]()
$390
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:51 pm -
1 stop5h 35m
Fri 10/2312:03 pm -
1 stop5h 08m
Deal found 8/3![Delta logo]()
$410
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:10 pm -
1 stop5h 45m
Sat 10/177:45 am -
2 stops7h 30m
Deal found 8/7![Southwest logo]()
$402
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2110:15 am -
1 stop9h 43m
Fri 12/2512:30 pm -
1 stop7h 22m
Deal found 8/7![Delta logo]()
$414
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:10 am -
2 stops8h 20m
Sat 9/2610:00 am -
2 stops8h 50m
Deal found 8/3![Southwest logo]()
$407
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:30 am -
1 stop7h 28m
Sun 12/612:59 am -
1 stop8h 20m
Deal found 8/7![Delta logo]()
$420
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/812:15 pm -
1 stop5h 30m
Fri 1/152:35 pm -
Nonstop2h 35m
Deal found 8/5![Southwest logo]()
$413
Last-minute flights from Des Moines to MesaDiscover last-minute flight deals from Des Moines to Mesa. Data last updated August 8, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mesa. Data last updated August 8, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:50 pm -
1 stop16h 58m
Thu 8/2710:30 pm -
1 stop18h 18m
Deal found 8/3![Multiple Airlines logo]()
$192
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:38 pm -
1 stop18h 21m
Thu 8/2710:30 pm -
1 stop18h 18m
Deal found 8/5![Multiple Airlines logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:54 pm -
1 stop18h 05m
Thu 9/39:03 am -
1 stop24h 07m
Deal found 8/3![Multiple Airlines logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
1 stop16h 28m
Tue 9/298:39 pm -
1 stop15h 13m
Deal found 8/7![Multiple Airlines logo]()
$163
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
1 stop16h 28m
Tue 10/68:39 pm -
1 stop15h 13m
Deal found 8/5![Multiple Airlines logo]()
$169
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
1 stop16h 28m
Thu 10/810:40 pm -
1 stop10h 17m
Deal found 8/5![Multiple Airlines logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
1 stop16h 28m
Wed 9/308:39 pm -
1 stop20h 47m
Deal found 8/7![Multiple Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:42 pm -
1 stop23h 40m
Tue 10/68:39 pm -
1 stop15h 13m
Deal found 8/5![Multiple Airlines logo]()
$196
One-way flights from Des Moines to MesaSearch for one-way flight options from Des Moines to Mesa. Find affordable one-way fares based on user searches. Data last updated August 8, 2026.
Search for one-way flight options from Des Moines to Mesa. Find affordable one-way fares based on user searches. Data last updated August 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:54 pm -
1 stop28h 30m
Deal found 8/7![Multiple Airlines logo]()
$92
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:04 pm -
1 stop16h 45m
Deal found 8/7![Multiple Airlines logo]()
$96
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:42 pm -
1 stop28h 08m
Deal found 8/5![Multiple Airlines logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/610:25 pm -
1 stop20h 25m
Deal found 8/7![Multiple Airlines logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/51:02 pm -
1 stop11h 45m
Deal found 8/5![Multiple Airlines logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:00 am -
1 stop29h 54m
Deal found 8/6![Multiple Airlines logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/81:42 pm -
1 stop28h 09m
Deal found 8/6![Multiple Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:00 pm -
1 stop25h 35m
Deal found 8/4![Multiple Airlines logo]()
$109
Find flight deals from Des Moines to Mesa
Keep the following information in mind while searching for Des Moines to Mesa flight deals. Data was last updated August 8, 2026.
Round-trip from | $163 (Kiwi.com) |
|---|---|
One-way from | $91 (Kiwi.com) |
Popular in | June |
Cheapest in | October |
Average price | $349 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 8, 2026.
Use the filters below to find and compare flights from Des Moines to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesPhoenix
DSM Des Moines - PHX Phoenix Sky Harbor Intl
DSMPHX
Des Moines
Thu 10/1
2:00 pm-3:05 pm
Nonstop3h 05m
Phoenix Sky Harbor Intl
Mon 10/5
1:50 pm-6:30 pm
Nonstop2h 40m
$377
Des MoinesPhoenix
DSM Des Moines - PHX Phoenix Sky Harbor Intl
DSMPHX
Des Moines
Fri 10/23
2:00 pm-3:05 pm
Nonstop3h 05m
Phoenix Sky Harbor Intl
Mon 10/26
1:50 pm-6:30 pm
Nonstop2h 40m
$390
Des MoinesPhoenix
DSM Des Moines - PHX Phoenix Sky Harbor Intl
DSMPHX
Des Moines
Wed 9/23
3:22 pm-9:37 pm
1 stop8h 15m
Phoenix Sky Harbor Intl
Sat 9/26
6:00 am-12:31 pm
1 stop4h 31m
$397
Des MoinesPhoenix
DSM Des Moines - PHX Phoenix Sky Harbor Intl
DSMPHX
Des Moines
Wed 11/18
11:00 am-5:39 pm
1 stop7h 39m
Phoenix Sky Harbor Intl
Mon 11/23
6:00 am-2:13 pm
1 stop7h 13m
$397
Des MoinesPhoenix
DSM Des Moines - PHX Phoenix Sky Harbor Intl
DSMPHX
Des Moines
Thu 10/15
7:10 pm-10:55 pm
1 stop5h 45m
Phoenix Sky Harbor Intl
Sat 10/17
7:45 am-5:15 pm
2 stops7h 30m
$402
Des MoinesPhoenix
DSM Des Moines - PHX Phoenix Sky Harbor Intl
DSMPHX
Des Moines
Wed 9/23
6:10 am-12:30 pm
2 stops8h 20m
Phoenix Sky Harbor Intl
Sat 9/26
10:00 am-8:50 pm
2 stops8h 50m
$407
Des MoinesPhoenix
DSM Des Moines - PHX Phoenix Sky Harbor Intl
DSMPHX
Des Moines
Tue 10/20
7:51 pm-11:26 pm
1 stop5h 35m
Phoenix Sky Harbor Intl
Fri 10/23
12:03 pm-7:11 pm
1 stop5h 08m
$410
Des MoinesPhoenix
DSM Des Moines - PHX Phoenix Sky Harbor Intl
DSMPHX
Des Moines
Fri 1/8
12:15 pm-4:45 pm
1 stop5h 30m
Phoenix Sky Harbor Intl
Fri 1/15
2:35 pm-6:10 pm
Nonstop2h 35m
$413
Des MoinesPhoenix
DSM Des Moines - PHX Phoenix Sky Harbor Intl
DSMPHX
Des Moines
Mon 12/21
10:15 am-6:58 pm
1 stop9h 43m
Phoenix Sky Harbor Intl
Fri 12/25
12:30 pm-8:52 pm
1 stop7h 22m
$414
Des MoinesPhoenix
DSM Des Moines - PHX Phoenix Sky Harbor Intl
DSMPHX
Des Moines
Fri 12/4
5:30 am-11:58 am
1 stop7h 28m
Phoenix Sky Harbor Intl
Sun 12/6
12:59 am-10:19 am
1 stop8h 20m
$420
Showing 1-10 of 18 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Des Moines with our price prediction graph.
DSM-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mesa
DSM-MS9
DSM-PHX
What is the cheapest time of day to fly from DSM to MS9?
Find hourly flight availability from Des Moines to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 8, 2026.
One of the essential ways to save on airfare from Des Moines to Mesa is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 35% on airfare.
Weekly flight availability from Des Moines to Mesa
Explore weekly flight availability from Des Moines to Mesa. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 8, 2026.
The most flights from DSM to MS9 are scheduled on a Thursday (4 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).
How much does it cost to fly round-trip from Des Moines to Mesa?
Airfare is below average for this route at the moment.
Des Moines to Mesa flights typically cost between $288 and $402 in September.The cheapest round-trip price found within the last 5 days was $163 on Multiple Airlines (Sep 28-Sep 29).
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated August 8, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAllegiant Air from Des Moines to Mesa. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Des Moines and Mesa flights
Browse other Des Moines and Mesa flight options. Last updated on August 8, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on August 8, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to Mesa flights
Consider these flights traveling from Des Moines to Mesa.
Top 7 airlines flying from Des Moines to Mesa
Discover the top 7 airlines that operate flights from Des Moines to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$133 | Average$264 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$152 | Average$340 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$160 | Average$303 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$187 | Average$359 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$200 | Average$363 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$212 | Average$391 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$219 | Average$328 | FlexibilityNo cancel fee | On-time62% |