HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$78+ Cheap flights from Mesa, AZ to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/8. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Jul 1 — Jul 81
Tue 7/1
Tue 7/8
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Mesa to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in April or October, booked 85 days in advance, depart on a Tuesday or Saturday and return on a Tuesday

Cheap flight deals from Mesa to Des Moines

Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated June 26, 2025.

Round-trip from

$192
(Southwest)

One-way from

$78
(Frontier)

Popular in

January

Cheapest in

April

Average price

$368
From Mesa to Des Moines
Search Deals
One-way flight from Mesa to Des Moines
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($37 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2025
Search Deals

Find flight deals from Mesa to Des Moines

Cheapest flights from Mesa to Des Moines
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 26, 2025.

This Southwest deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2111:40 amPHX - DSM
2 stops8h 10mSouthwest
Wed 10/227:25 amDSM - PHX
Nonstop3h 10mSouthwest
Deal found 6/26$192
This Priceline deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/117:18 amPHX - DSM
1 stop9h 30mFrontier
Mon 8/187:33 pmDSM - PHX
1 stop5h 51mFrontier
Deal found 6/26$194
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/237:09 pmPHX - DSM
Nonstop2h 50mAmerican Airlines
Wed 7/305:35 amDSM - PHX
Nonstop3h 02mAmerican Airlines
Deal found 6/24$230
This Delta deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2212:45 amPHX - DSM
1 stop7h 31mDelta
Wed 7/305:30 amDSM - PHX
1 stop8h 57mDelta
Deal found 6/24$254
This United Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/104:28 pmPHX - DSM
1 stop5h 31mUnited Airlines
Thu 8/146:02 amDSM - PHX
1 stop7h 00mUnited Airlines
Deal found 6/26$271
This Mytrip deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1410:42 pmPHX - DSM
2 stops17h 06mMultiple Airlines
Thu 8/218:30 amDSM - PHX
2 stops15h 07mMultiple Airlines
Deal found 6/26$307
This Mytrip deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/182:24 pmPHX - DSM
2 stops28h 49mAllegiant Air
Sun 7/203:45 pmDSM - PHX
2 stops23h 49mAllegiant Air
Deal found 6/26$372
This Alaska Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/177:00 amPHX - DSM
2 stops24h 33mAlaska Airlines
Mon 10/204:02 pmDSM - PHX
2 stops20h 03mAlaska Airlines
Deal found 6/26$431

Cheapflights Fare Finder

Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 26, 2025.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.

Fly from

Mesa

Fly to

Des Moines

Route

Depart

Return

Price

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Tue 10/21

11:40 am-9:50 pm

2 stops8h 10m

Des Moines

Wed 10/22

7:25 am-8:35 am

Nonstop3h 10m

$192

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Mon 8/11

7:18 am-6:48 pm

1 stop9h 30m

Des Moines

Mon 8/18

7:33 pm-11:24 pm

1 stop5h 51m

$194

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 7/23

7:09 pm-11:59 pm

Nonstop2h 50m

Des Moines

Wed 7/30

5:35 am-6:37 am

Nonstop3h 02m

$230

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Tue 7/22

12:45 am-10:16 am

1 stop7h 31m

Des Moines

Wed 7/30

5:30 am-12:27 pm

1 stop8h 57m

$254

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Sun 8/10

4:28 pm-11:59 pm

1 stop5h 31m

Des Moines

Thu 8/14

6:02 am-11:02 am

1 stop7h 00m

$271

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 8/14

10:42 pm-5:48 pm

2 stops17h 06m

Des Moines

Thu 8/21

8:30 am-9:37 pm

2 stops15h 07m

$307

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Fri 7/18

2:24 pm-9:13 pm

2 stops28h 49m

Des Moines

Sun 7/20

3:45 pm-1:34 pm

2 stops23h 49m

$372

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Fri 10/17

7:00 am-9:33 am

2 stops24h 33m

Des Moines

Mon 10/20

4:02 pm-10:05 am

2 stops20h 03m

$431

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 10/8

6:33 am-2:43 pm

1 stop6h 10m

$78

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Mon 10/6

11:20 am-4:00 pm

Nonstop2h 40m

$79

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/26

Showing 1-10 of 15 results
1
2

Best time to book a flight from Mesa to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Des Moines

How far ahead should I book a flight from Mesa to Des Moines?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Des Moines. Price data was last updated on June 20, 2025.

The price you pay for your flight from Mesa to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 85 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $336). Flying from Mesa to Des Moines in June is currently the most expensive (average of $406). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to DSM?

Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 26, 2025.

When flying from Mesa to Des Moines, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Mesa to Des Moines?

Use this chart to determine the cheapest time to fly round-trip from Mesa to Des Moines. Price data was last updated on June 22, 2025.

Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Tuesday evenings when fares are most often at their lowest. Wednesday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Mesa to Des Moines

Explore weekly flight availability from Mesa to Des Moines. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 26, 2025.

The most flights from MS9 to DSM are scheduled on a Monday (4 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (4 on average).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated June 26, 2025.
Read reviews from past customers who have flown Alaska Airlines, Southwest, and Delta from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Comfort

7.8

Food

7.1

Crew

8.5

Boarding

8.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Comfort

7.8

Food

7.1

Crew

8.5

Boarding

8.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Southwest
8.0
Very good
4,276 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Comfort

7.8

Food

7.1

Crew

8.5

Boarding

8.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,963 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Comfort

7.8

Food

7.1

Crew

8.5

Boarding

8.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,838 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Comfort

7.8

Food

7.1

Crew

8.5

Boarding

8.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Comfort

7.8

Food

7.1

Crew

8.5

Boarding

8.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mesa?

    For a flight from Mesa to Des Moines, you will be flying into Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 4 inbound flights from Mesa per day. 6 airlines have flights to Des Moines from Mesa on a regular basis.

  • What are the cheapest airlines to fly from Mesa to Des Moines one-way?

    One-way options have recently been found by users for as low as $78 on Frontier. Other airlines that offer cheap prices include Southwest from $79 and American Airlines from $101 one-way.

  • What are the most reliable airlines from Mesa to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mesa to Des Moines on time: Alaska Airlines (88%), SkyWest Airlines (88%), Southwest (88%).

  • What are the cheapest flights from Mesa to Des Moines?

    While on average a flight from Mesa to Des Moines is generally $294, our data shows the cheapest flight currently is $93. When looking at the most popular route, (Phoenix Sky Harbor Intl - Des Moines), you can expect to pay $176 for that flight.

  • Can I find deals for flights from Mesa to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mesa to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Des Moines.

  • Can I find deals for business class flights from Mesa to Des Moines?

    Yes. Cheapflights offers flight deals from Mesa to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $336). Flying from Mesa to Des Moines in June is currently the most expensive (average of $406). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Mesa?

Book flights to Mesa if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mesa to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
Sky Harbor Intl to Cedar Rapids flights
Sky Harbor Intl to Omaha flights
Sky Harbor Intl to Des Moines flights
Las Vegas to Omaha flights
Sky Harbor Intl to Moline flights
Tucson to Des Moines flights
Las Vegas to Des Moines flights
Tucson to Omaha flights
Tucson to Cedar Rapids flights
Sky Harbor Intl to La Crosse flights
Tucson to Moline flights
Las Vegas to Cedar Rapids flights
Phoenix-Mesa Gateway to Des Moines flights
Las Vegas to Moline flights
Flagstaff to Omaha flights
Sky Harbor Intl to Sioux City flights
Sky Harbor Intl to Dubuque flights
Sky Harbor Intl to Waterloo flights
Tucson to Sioux City flights
Flagstaff to Cedar Rapids flights
Tucson to Waterloo flights
Las Vegas to Burlington flights
Tucson to La Crosse flights
Sky Harbor Intl to Burlington flights
Yuma to Des Moines flights
Yuma to Omaha flights

Top 6 airlines flying from Mesa to Des Moines

Discover the top 6 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$100Average$202FlexibilityNo cancel feeOn-time88%
FrontierCheapest$104Average$201FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$203Average$367FlexibilityNo cancel feeOn-time71%
DeltaCheapest$216Average$307FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$216Average$462FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$218Average$376FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.