$85+ Cheap flights from Des Moines (DSM) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PHX
May 25 — Jun 11
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to Mesa are usually found in October or August, booked 53 days in advance, depart on a Wednesday or Saturday and return on a Tuesday
Cheap flight deals from Des Moines to Mesa
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Best
Last-minute
One-way
Cheapest flights from Des Moines to MesaExplore the most affordable flight options available from Des Moines to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 25, 2026.
Explore the most affordable flight options available from Des Moines to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 25, 2026.
This Expedia deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- PHX
1 stop27h 39m
Frontier
Sun 5/106:51 pm
PHX
- DSM
1 stop16h 40m
Frontier
Deal found 4/21![Frontier logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- PHX
1 stop22h 00m
Frontier
Tue 6/1610:27 pm
PHX
- DSM
2 stops13h 04m
Frontier
Deal found 4/21![Frontier logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3110:26 pm
DSM
- PHX
2 stops21h 26m
Multiple Airlines
Wed 6/310:27 pm
PHX
- DSM
1 stop19h 44m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$263
This Frontier deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- PHX
1 stop11h 38m
Frontier
Mon 5/115:15 am
PHX
- DSM
1 stop6h 16m
Frontier
Deal found 4/20![Frontier logo]()
$266
This Super.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:04 pm
DSM
- PHX
1 stop11h 38m
Frontier
Thu 5/284:17 pm
PHX
- DSM
1 stop19h 14m
Frontier
Deal found 4/22![Frontier logo]()
$268
This Frontier deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/272:16 pm
DSM
- PHX
1 stop11h 18m
Frontier
Fri 7/315:15 am
PHX
- DSM
1 stop6h 16m
Frontier
Deal found 4/22![Frontier logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:45 am
DSM
- PHX
2 stops38h 48m
Multiple Airlines
Tue 5/2610:27 pm
PHX
- DSM
1 stop12h 32m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3110:26 pm
DSM
- PHX
1 stop14h 57m
Multiple Airlines
Tue 6/210:27 pm
PHX
- DSM
1 stop12h 28m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- PHX
1 stop22h 00m
Multiple Airlines
Wed 6/1711:32 am
PHX
- DSM
2 stops32h 15m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$274
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1612:30 pm
DSM
- PHX
1 stop7h 05m
Southwest
Sat 9/265:25 am
PHX
- DSM
1 stop8h 45m
Southwest
Deal found 4/20![Southwest logo]()
$277
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/222:16 pm
DSM
- PHX
1 stop19h 28m
Multiple Airlines
Tue 5/2610:27 pm
PHX
- DSM
1 stop12h 32m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$279
Best flights from Des Moines to MesaDiscover carefully curated flight deals from Des Moines to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 25, 2026.
Discover carefully curated flight deals from Des Moines to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 25, 2026.
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:30 am
DSM
- PHX
1 stop7h 30m
Southwest
Sun 5/3111:00 am
PHX
- DSM
Nonstop2h 40m
Southwest
Deal found 4/20![Southwest logo]()
$348
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:44 pm
DSM
- PHX
1 stop8h 27m
Delta
Sat 5/910:55 pm
PHX
- DSM
1 stop8h 51m
Delta
Deal found 4/20![Delta logo]()
$451
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/910:02 am
DSM
- PHX
2 stops9h 06m
United Airlines
Wed 5/134:39 pm
PHX
- DSM
1 stop5h 05m
United Airlines
Deal found 4/21![United Airlines logo]()
$453
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/184:40 pm
DSM
- PHX
1 stop7h 35m
Southwest
Mon 6/222:35 pm
PHX
- DSM
1 stop6h 55m
Southwest
Deal found 4/23![Southwest logo]()
$407
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:23 pm
DSM
- PHX
1 stop5h 27m
Delta
Tue 5/1211:46 pm
PHX
- DSM
1 stop9h 22m
Delta
Deal found 4/21![Delta logo]()
$466
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:20 am
DSM
- PHX
1 stop9h 10m
United Airlines
Mon 7/611:50 pm
PHX
- DSM
1 stop8h 37m
United Airlines
Deal found 4/24![United Airlines logo]()
$468
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/21:30 pm
DSM
- PHX
2 stops8h 15m
Southwest
Mon 7/1311:20 am
PHX
- DSM
2 stops9h 00m
Southwest
Deal found 4/22![Southwest logo]()
$434
This Southwest deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:10 am
DSM
- PHX
2 stops8h 05m
Southwest
Fri 6/51:45 pm
PHX
- DSM
2 stops7h 45m
Southwest
Deal found 4/24![Southwest logo]()
$450
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:45 pm
DSM
- PHX
Nonstop2h 55m
Southwest
Wed 5/131:40 pm
PHX
- DSM
1 stop5h 35m
Southwest
Deal found 4/20![Southwest logo]()
$453
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/912:05 pm
DSM
- PHX
2 stops10h 30m
Southwest
Wed 5/1311:35 am
PHX
- DSM
2 stops7h 40m
Southwest
Deal found 4/20![Southwest logo]()
$458
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:10 am
DSM
- PHX
2 stops8h 05m
Southwest
Thu 6/111:45 pm
PHX
- DSM
2 stops7h 45m
Southwest
Deal found 4/20![Southwest logo]()
$462
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/193:15 pm
DSM
- PHX
2 stops8h 15m
Southwest
Thu 5/212:05 pm
PHX
- DSM
2 stops7h 00m
Southwest
Deal found 4/23![Southwest logo]()
$467
Last-minute flights from Des Moines to MesaDiscover last-minute flight deals from Des Moines to Mesa. Data last updated April 25, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mesa. Data last updated April 25, 2026 and is based on user searches.
This Super.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:04 pm
DSM
- PHX
1 stop11h 38m
Frontier
Thu 5/284:17 pm
PHX
- DSM
1 stop19h 14m
Frontier
Deal found 4/22![Frontier logo]()
$268
This Frontier deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- PHX
1 stop11h 38m
Frontier
Mon 5/115:15 am
PHX
- DSM
1 stop6h 16m
Frontier
Deal found 4/20![Frontier logo]()
$266
This Expedia deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- PHX
1 stop27h 39m
Frontier
Sun 5/106:51 pm
PHX
- DSM
1 stop16h 40m
Frontier
Deal found 4/21![Frontier logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:45 am
DSM
- PHX
2 stops38h 48m
Multiple Airlines
Tue 5/2610:27 pm
PHX
- DSM
1 stop12h 32m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/222:16 pm
DSM
- PHX
1 stop19h 28m
Multiple Airlines
Tue 5/2610:27 pm
PHX
- DSM
1 stop12h 32m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:36 pm
DSM
- PHX
1 stop15h 47m
Multiple Airlines
Tue 6/210:27 pm
PHX
- DSM
1 stop12h 28m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:36 pm
DSM
- PHX
1 stop15h 47m
Multiple Airlines
Wed 6/310:27 pm
PHX
- DSM
1 stop19h 44m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:36 pm
DSM
- PHX
1 stop15h 47m
Multiple Airlines
Thu 6/47:40 am
PHX
- DSM
1 stop10h 31m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3110:26 pm
DSM
- PHX
2 stops21h 26m
Multiple Airlines
Wed 6/310:27 pm
PHX
- DSM
1 stop19h 44m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3110:26 pm
DSM
- PHX
1 stop14h 57m
Multiple Airlines
Tue 6/210:27 pm
PHX
- DSM
1 stop12h 28m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$273
One-way flights from Des Moines to MesaSearch for one-way flight options from Des Moines to Mesa. Find affordable one-way fares based on user searches. Data last updated April 25, 2026.
Search for one-way flight options from Des Moines to Mesa. Find affordable one-way fares based on user searches. Data last updated April 25, 2026.
This Super.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:16 pm
DSM
- PHX
1 stop8h 54m
Frontier
Deal found 4/24![Frontier logo]()
$85
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- PHX
2 stops27h 15m
Frontier
Deal found 4/24![Frontier logo]()
$98
This Super.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- PHX
1 stop27h 39m
Frontier
Deal found 4/21![Frontier logo]()
$104
This Frontier deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:16 pm
DSM
- PHX
1 stop8h 54m
Frontier
Deal found 4/21![Frontier logo]()
$106
This Frontier deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/222:16 pm
DSM
- PHX
1 stop11h 18m
Frontier
Deal found 4/21![Frontier logo]()
$111
This Super.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
- PHX
1 stop5h 19m
Frontier
Deal found 4/21![Frontier logo]()
$120
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:00 pm
DSM
- PHX
1 stop4h 55m
Southwest
Deal found 4/23![Southwest logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/152:16 pm
DSM
- PHX
1 stop22h 00m
Frontier
Deal found 4/23![Frontier logo]()
$126
This Frontier deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- PHX
1 stop11h 38m
Frontier
Deal found 4/21![Frontier logo]()
$127
Find flight deals from Des Moines to Mesa
Keep the following information in mind while searching for Des Moines to Mesa flight deals. Data was last updated April 25, 2026.
Round-trip from | $255 (Expedia) |
|---|---|
One-way from | $85 (Super.com) |
Popular in | April |
Cheapest in | October |
Average price | $405 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 25, 2026.
Use the filters below to find and compare flights from Des Moines to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Wed 5/27
5:30 am-11:00 am
1 stop7h 30m
Phoenix Sky Harbor Intl
Sun 5/31
11:00 am-3:40 pm
Nonstop2h 40m
$348
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Thu 6/18
4:40 pm-10:15 pm
1 stop7h 35m
Phoenix Sky Harbor Intl
Mon 6/22
2:35 pm-11:30 pm
1 stop6h 55m
$407
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Thu 7/2
1:30 pm-7:45 pm
2 stops8h 15m
Phoenix Sky Harbor Intl
Mon 7/13
11:20 am-10:20 pm
2 stops9h 00m
$434
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Fri 6/5
6:10 am-12:15 pm
2 stops8h 05m
Phoenix Sky Harbor Intl
Fri 6/5
1:45 pm-11:30 pm
2 stops7h 45m
$450
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Sat 5/2
2:44 pm-9:11 pm
1 stop8h 27m
Phoenix Sky Harbor Intl
Sat 5/9
10:55 pm-9:46 am
1 stop8h 51m
$451
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Sat 5/9
10:02 am-5:08 pm
2 stops9h 06m
Phoenix Sky Harbor Intl
Wed 5/13
4:39 pm-11:44 pm
1 stop5h 05m
$453
Quickest round-trip
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Fri 5/8
1:45 pm-2:40 pm
Nonstop2h 55m
Phoenix Sky Harbor Intl
Wed 5/13
1:40 pm-9:15 pm
1 stop5h 35m
$453
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Sat 5/9
12:05 pm-8:35 pm
2 stops10h 30m
Phoenix Sky Harbor Intl
Wed 5/13
11:35 am-9:15 pm
2 stops7h 40m
$458
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Thu 6/4
6:10 am-12:15 pm
2 stops8h 05m
Phoenix Sky Harbor Intl
Thu 6/11
1:45 pm-11:30 pm
2 stops7h 45m
$462
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Fri 5/1
4:23 pm-7:50 pm
1 stop5h 27m
Phoenix Sky Harbor Intl
Tue 5/12
11:46 pm-11:08 am
1 stop9h 22m
$466
Showing 1-10 of 21 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Des Moines with our price prediction graph.
DSM-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mesa
DSM-MS9
DSM-PHX
What is the cheapest time of day to fly from DSM to MS9?
Find hourly flight availability from Des Moines to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 25, 2026.
One of the essential ways to save on airfare from Des Moines to Mesa is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight at noon could potentially save you up to 39% on airfare.
Weekly flight availability from Des Moines to Mesa
Explore weekly flight availability from Des Moines to Mesa. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated April 25, 2026.
The most flights from DSM to MS9 are scheduled on a Monday (7 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (4 on average).
How much does it cost to fly round-trip from Des Moines to Mesa?
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated April 25, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAllegiant Air from Des Moines to Mesa. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Des Moines and Mesa flights
Browse other Des Moines and Mesa flight options. Last updated on April 25, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on April 25, 2026.
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Des Moines to Mesa flights
Consider these flights traveling from Des Moines to Mesa.
Top 7 airlines flying from Des Moines to Mesa
Discover the top 7 airlines that operate flights from Des Moines to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$122 | Average$241 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$152 | Average$287 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$160 | Average$274 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$187 | Average$357 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$195 | Average$346 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$212 | Average$391 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$219 | Average$328 | FlexibilityNo cancel fee | On-time62% |