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Mesa

$78+ Cheap flights from Des Moines (DSM) to Mesa, AZ

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PHX
oct. 16 — oct. 231
jue. 10/16
jue. 10/23
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Mesa are usually found in October or January, booked 53 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from Des Moines to Mesa

Keep the following information in mind while searching for Des Moines to Mesa flight deals. Data was last updated septiembre 16, 2025.

Round-trip from

$177
(American Airlines)

One-way from

$78
(Trip.com)

Popular in

March

Cheapest in

October

Average price

$313
From Des Moines to Mesa
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One-way flight from Des Moines to Mesa
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Highest demand for flights based on searches. 11% potential increase in price ($44 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Mesa

Cheapest flights from Des Moines to Mesa
Explore the most affordable flight options available from Des Moines to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 16, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/35:00 amDSM - PHX
Nonstop3h 20mAmerican Airlines
mié. 12/108:12 pmPHX - DSM
Nonstop2h 47mAmerican Airlines
Deal found 9/15$177
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/135:00 amDSM - PHX
Nonstop3h 20mAmerican Airlines
sáb. 1/179:30 amPHX - DSM
Nonstop2h 51mAmerican Airlines
Deal found 9/14$178
This Priceline deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/262:25 pmDSM - PHX
1 stop7h 00mFrontier
lun. 9/297:00 amPHX - DSM
1 stop4h 40mFrontier
Deal found 9/14$179
This Frontier deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/222:37 pmDSM - PHX
1 stop5h 44mFrontier
vie. 10/316:36 amPHX - DSM
1 stop5h 11mFrontier
Deal found 9/15$180
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/82:37 pmDSM - PHX
1 stop5h 44mFrontier
mar. 10/144:14 pmPHX - DSM
1 stop19h 38mFrontier
Deal found 9/15$183
This Frontier deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/302:32 pmDSM - PHX
1 stop10h 23mFrontier
dom. 11/27:30 amPHX - DSM
1 stop5h 17mFrontier
Deal found 9/15$184
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/206:15 pmDSM - PHX
1 stop7h 20mSouthwest
sáb. 10/254:10 pmPHX - DSM
Nonstop2h 40mSouthwest
Deal found 9/15$187
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/133:35 pmDSM - PHX
Nonstop3h 10mSouthwest
sáb. 1/178:55 amPHX - DSM
1 stop5h 00mSouthwest
Deal found 9/14$188
This Priceline deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/202:39 pmDSM - PHX
1 stop9h 37mFrontier
mié. 10/226:33 amPHX - DSM
1 stop5h 19mFrontier
Deal found 9/14$189
This Priceline deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/262:25 pmDSM - PHX
1 stop4h 48mFrontier
dom. 9/286:00 amPHX - DSM
1 stop5h 40mFrontier
Deal found 9/15$192
This Frontier deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/252:25 pmDSM - PHX
1 stop11h 02mFrontier
lun. 9/297:00 amPHX - DSM
1 stop4h 40mFrontier
Deal found 9/14$195

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 16, 2025.
Use the filters below to find and compare flights from Des Moines to Mesa that are best for you.

Fly from

Des Moines

Fly to

Mesa

Route

Depart

Return

Price

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

sáb. 10/25

3:30 pm-8:01 pm

1 stop6h 31m

Phoenix Sky Harbor Intl

mié. 10/29

10:40 pm-9:20 am

1 stop8h 40m

$237

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

mar. 2/24

5:15 pm-12:16 am

1 stop8h 01m

Phoenix Sky Harbor Intl

mar. 3/3

11:55 pm-9:30 am

1 stop8h 35m

$237

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

mar. 10/21

5:32 pm-11:04 pm

1 stop7h 32m

Phoenix Sky Harbor Intl

vie. 10/31

10:40 pm-9:19 am

1 stop8h 39m

$254

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

vie. 11/14

4:59 pm-11:59 pm

1 stop8h 00m

Phoenix Sky Harbor Intl

mié. 11/26

7:05 am-2:05 pm

1 stop6h 00m

$254

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

mar. 10/21

5:32 pm-11:04 pm

1 stop7h 32m

Phoenix Sky Harbor Intl

mié. 10/29

7:05 am-1:59 pm

1 stop4h 54m

$254

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

mar. 11/11

10:21 am-7:17 pm

1 stop9h 56m

Phoenix Sky Harbor Intl

vie. 11/14

12:59 am-10:20 am

1 stop8h 21m

$254

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

dom. 2/22

10:15 am-7:09 pm

1 stop9h 54m

Phoenix Sky Harbor Intl

mar. 3/3

11:55 pm-9:30 am

1 stop8h 35m

$289

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

jue. 10/23

4:35 pm-5:35 pm

Nonstop3h 00m

Phoenix Sky Harbor Intl

mar. 10/28

1:30 pm-8:55 pm

1 stop5h 25m

$294

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

mar. 11/18

4:59 pm-9:14 pm

1 stop5h 15m

Phoenix Sky Harbor Intl

jue. 11/27

12:59 am-10:20 am

1 stop8h 21m

$306

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

vie. 10/3

5:25 pm-8:53 pm

1 stop5h 28m

Phoenix Sky Harbor Intl

lun. 10/6

12:40 am-10:26 am

1 stop7h 46m

$312

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 23 results
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Best time to book a flight from Des Moines to Mesa

Have a flexible travel schedule? Discover the best time to fly to Mesa from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mesa

How far ahead should I book a flight from Des Moines to Mesa?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Mesa. Price data was last updated on September 12, 2025.

To ensure you get the cheapest price possible for a flight from Des Moines to Mesa, you should look to book at least 53 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Des Moines to Mesa?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Mesa (average of $258). Flying from Des Moines to Mesa in March is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to MS9?

Find hourly flight availability from Des Moines to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 16, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Mesa as you normally would.

What is the cheapest day to fly from Des Moines to Mesa?

Use this chart to determine the cheapest time to fly round-trip from Des Moines to Mesa. Price data was last updated on September 14, 2025.

Travelers seeking maximum savings on their Des Moines to Mesa flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Des Moines to Mesa

Explore weekly flight availability from Des Moines to Mesa. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated septiembre 16, 2025.

The most flights from DSM to MS9 are scheduled on a Thursday (6 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Mesa

Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated septiembre 16, 2025.
Read reviews from past customers who have flown Southwest, United Airlines, and American Airlines from Des Moines to Mesa. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,924 reviews
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Allegiant Air
7.2
Good
699 reviews
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Frontier
5.8
Fair
3,174 reviews
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mesa?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Mesa from Des Moines. Booking flights from Des Moines (DSM) to Mesa should be relatively easy as there are 4 daily outbound flights to Mesa from 6 different airlines.

  • How long is the flight from Des Moines to Mesa?

    For as low as $237, Delta can have you in Mesa from Des Moines in 6h 31m. The distance between Des Moines and Mesa is about 1147 mi.

  • What are the most reliable airlines from Des Moines to Mesa?

    Before booking your flight to Mesa from Des Moines, check out the most reliable airlines to get you to your destination on time: American Airlines (86%), SkyWest Airlines (84%), Alaska Airlines( 83%).

  • What are the cheapest flights from Des Moines to Mesa?

    Looking at all options, your cheapest flight can be booked for $88. While the most popular route (Des Moines - Phoenix Sky Harbor Intl) can be booked for $187 on average, our data indicates $293 when flying from Des Moines to Mesa.

  • Can I find deals for flights from Des Moines to Mesa that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mesa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mesa.

  • Can I find deals for business class flights from Des Moines to Mesa?

    Yes. Cheapflights offers flight deals from Des Moines to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mesa?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Mesa (average of $258). Flying from Des Moines to Mesa in March is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Mesa

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Top 6 airlines flying from Des Moines to Mesa

Discover the top 6 airlines that operate flights from Des Moines to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$106Average$263FlexibilityNo cancel feeOn-time62%
Allegiant AirCheapest$119Average$213FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$197Average$344FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$201Average$332FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$216Average$390FlexibilityNo cancel feeOn-time69%
DeltaCheapest$236Average$302FlexibilityNo cancel feeOn-timeN/A

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