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$61+ Cheap flights from Des Moines (DSM) to Mesa, AZ

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PHX
Mar 2 — Mar 91
Mon 3/2
Mon 3/9
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Mesa are usually found in October or August, booked 54 days in advance, depart on a Wednesday or Saturday and return on a Tuesday

Cheap flight deals from Des Moines to Mesa

Cheapest flights from Des Moines to Mesa
Explore the most affordable flight options available from Des Moines to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 31, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:59 pm
DSM
-
PHX
1 stop13h 13m
Frontier
Mon 3/25:05 am
PHX
-
DSM
2 stops12h 27m
Frontier
Deal found 1/29$229
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:27 pm
DSM
-
PHX
1 stop13h 45m
Frontier
Sat 3/79:52 am
PHX
-
DSM
1 stop8h 24m
Frontier
Deal found 1/29$231
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:27 pm
DSM
-
PHX
1 stop6h 14m
Frontier
Mon 3/96:50 am
PHX
-
DSM
1 stop10h 26m
Frontier
Deal found 1/30$232
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/84:30 pm
DSM
-
PHX
2 stops43h 00m
Multiple Airlines
Wed 2/186:51 pm
PHX
-
DSM
1 stop22h 56m
Multiple Airlines
Deal found 1/29$233
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/118:21 pm
DSM
-
PHX
2 stops29h 08m
Frontier
Mon 3/166:50 am
PHX
-
DSM
1 stop10h 26m
Frontier
Deal found 1/29$234
This Priceline deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:20 pm
DSM
-
PHX
1 stop7h 50m
Frontier
Mon 4/276:50 am
PHX
-
DSM
1 stop4h 39m
Frontier
Deal found 1/29$235
This Expedia deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/108:14 pm
DSM
-
PHX
1 stop5h 33m
Frontier
Mon 4/136:50 am
PHX
-
DSM
1 stop10h 24m
Frontier
Deal found 1/30$236
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/188:21 pm
DSM
-
PHX
1 stop13h 21m
Frontier
Wed 3/256:50 am
PHX
-
DSM
1 stop10h 26m
Frontier
Deal found 1/30$238
This Delta deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/175:20 pm
DSM
-
PHX
1 stop7h 29m
Delta
Tue 3/2411:59 pm
PHX
-
DSM
1 stop8h 10m
Delta
Deal found 1/30$239

Find flight deals from Des Moines to Mesa

Keep the following information in mind while searching for Des Moines to Mesa flight deals. Data was last updated January 31, 2026.

Round-trip from

$229
(Kiwi.com)

One-way from

$61
(Frontier)

Popular in

March

Cheapest in

October

Average price

$320
From Des Moines to Mesa
Search Deals
One-way flight from Des Moines to Mesa
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($37 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 31, 2026.
Use the filters below to find and compare flights from Des Moines to Mesa that are best for you.

Fly from

Des Moines

Fly to

Mesa

Route

Depart

Return

Price

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Wed 3/25

6:35 pm-9:35 pm

1 stop5h 00m

Phoenix Sky Harbor Intl

Tue 3/31

5:25 am-1:15 pm

1 stop5h 50m

$239

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Tue 3/10

4:25 pm-9:52 pm

1 stop7h 27m

Phoenix Sky Harbor Intl

Tue 3/17

11:59 pm-10:09 am

1 stop8h 10m

$239

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Sat 3/28

7:55 pm-9:00 pm

Nonstop3h 05m

Phoenix Sky Harbor Intl

Sat 4/4

2:35 pm-7:15 pm

Nonstop2h 40m

$250

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Tue 3/3

8:35 am-3:35 pm

1 stop8h 00m

Phoenix Sky Harbor Intl

Tue 3/10

10:10 am-2:55 pm

Nonstop2h 45m

$254

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Tue 4/7

10:51 am-4:24 pm

1 stop7h 33m

Phoenix Sky Harbor Intl

Sat 4/11

6:05 am-3:42 pm

1 stop7h 37m

$264

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Sat 6/13

5:12 pm-8:31 pm

1 stop5h 19m

Phoenix Sky Harbor Intl

Tue 6/16

4:21 pm-11:55 pm

1 stop5h 34m

$289

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Fri 3/6

7:10 pm-11:00 pm

1 stop4h 50m

Phoenix Sky Harbor Intl

Tue 3/10

10:10 am-2:55 pm

Nonstop2h 45m

$289

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Tue 3/3

8:00 am-3:29 pm

2 stops8h 29m

Phoenix Sky Harbor Intl

Tue 3/10

9:33 am-4:07 pm

1 stop4h 34m

$314

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Wed 2/25

4:20 pm-12:11 am

1 stop8h 51m

Phoenix Sky Harbor Intl

Tue 3/3

11:59 pm-9:56 am

1 stop8h 57m

$317

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Tue 2/24

5:15 pm-11:42 pm

1 stop7h 27m

Phoenix Sky Harbor Intl

Wed 3/4

7:10 am-3:40 pm

1 stop7h 30m

$317

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/29

Showing 1-10 of 19 results
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Best time to book a flight from Des Moines to Mesa

Have a flexible travel schedule? Discover the best time to fly to Mesa from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mesa

How far ahead should I book a flight from Des Moines to Mesa?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Mesa. Price data was last updated on January 30, 2026.

To ensure you get the cheapest price possible for a flight from Des Moines to Mesa, you should look to book at least 54 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Des Moines to Mesa?

Currently, December is the cheapest month in which you can book a flight from Des Moines to Mesa (average of $54). Flying from Des Moines to Mesa in February is currently the most expensive (average of $165). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to MS9?

Find hourly flight availability from Des Moines to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 31, 2026.

One of the essential ways to save on airfare from Des Moines to Mesa is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight at noon could potentially save you up to 39% on airfare.

Weekly flight availability from Des Moines to Mesa

Explore weekly flight availability from Des Moines to Mesa. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated January 31, 2026.

The most flights from DSM to MS9 are scheduled on a Thursday (6 on average). You will have fewer flight options on Wednesday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Mesa

Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated January 31, 2026.
Read reviews from past customers who have flown Southwest, United Airlines, and American Airlines from Des Moines to Mesa. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,267 reviews
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,219 reviews
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,213 reviews
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Allegiant Air
7.2
Good
707 reviews
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Frontier
5.7
Fair
3,054 reviews
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mesa?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Mesa from Des Moines. Booking flights from Des Moines (DSM) to Mesa should be relatively easy as there are 4 daily outbound flights to Mesa from 7 different airlines.

  • How long is the flight from Des Moines to Mesa?

    For as low as $239, Southwest can have you in Mesa from Des Moines in 5h. The distance between Des Moines and Mesa is about 1147 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Des Moines to Mesa one-way?

    $75 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on American Airlines and Southwest, with prices starting from $89 and $99, respectively.

  • What are the most reliable airlines from Des Moines to Mesa?

    Before booking your flight to Mesa from Des Moines, check out the most reliable airlines to get you to your destination on time: Envoy Air (100%), SkyWest Airlines (92%), American Airlines( 85%).

  • What are the cheapest flights from Des Moines to Mesa?

    Looking at all options, your cheapest flight can be booked for $148. While the most popular route (Des Moines - Phoenix Sky Harbor Intl) can be booked for $178 on average, our data indicates $1,066 when flying from Des Moines to Mesa.

  • Can I find deals for flights from Des Moines to Mesa that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mesa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mesa.

  • Can I find deals for business class flights from Des Moines to Mesa?

    Yes. Cheapflights offers flight deals from Des Moines to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mesa?

    Currently, December is the cheapest month in which you can book a flight from Des Moines to Mesa (average of $54). Flying from Des Moines to Mesa in February is currently the most expensive (average of $165). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Mesa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from Des Moines to Mesa

Discover the top 7 airlines that operate flights from Des Moines to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 31, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$112Average$208FlexibilityNo cancel feeOn-time88%
FrontierCheapest$125Average$258FlexibilityNo cancel feeOn-time62%
SouthwestCheapest$187Average$348FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$191Average$344FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$212Average$399FlexibilityNo cancel feeOn-time69%
DeltaCheapest$216Average$287FlexibilityNo cancel feeOn-timeN/A
JetBlueCheapest$219Average$310FlexibilityNo cancel feeOn-time62%

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