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$67+ Cheap flights from Des Moines (DSM) to Mesa, AZ

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PHX
Apr 25 — May 21
Sat 4/25
Sat 5/2
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Mesa are usually found in October or August, booked 53 days in advance, depart on a Wednesday or Saturday and return on a Tuesday

Cheap flight deals from Des Moines to Mesa

Cheapest flights from Des Moines to Mesa
Explore the most affordable flight options available from Des Moines to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2026.

This Frontier deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:04 pm
DSM
-
PHX
1 stop11h 38m
Frontier
Mon 5/46:50 am
PHX
-
DSM
1 stop10h 48m
Frontier
Deal found 3/23$245
This Frontier deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/288:21 pm
DSM
-
PHX
1 stop5h 30m
Frontier
Mon 4/66:50 am
PHX
-
DSM
1 stop10h 24m
Frontier
Deal found 3/23$250
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:04 pm
DSM
-
PHX
1 stop20h 34m
Multiple Airlines
Wed 4/292:05 pm
PHX
-
DSM
1 stop25h 56m
Multiple Airlines
Deal found 3/25$252
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/271:45 pm
DSM
-
PHX
Nonstop2h 55m
Southwest
Wed 4/292:35 pm
PHX
-
DSM
1 stop4h 40m
Southwest
Deal found 3/25$253
This Super.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/288:21 pm
DSM
-
PHX
1 stop5h 30m
Frontier
Sun 3/299:24 pm
PHX
-
DSM
1 stop19h 52m
Frontier
Deal found 3/21$256
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2010:00 am
DSM
-
PHX
1 stop8h 08m
Multiple Airlines
Tue 4/286:51 pm
PHX
-
DSM
2 stops47h 22m
Multiple Airlines
Deal found 3/23$257
This Priceline deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:21 pm
DSM
-
PHX
1 stop5h 30m
Frontier
Mon 3/308:52 am
PHX
-
DSM
1 stop8h 24m
Frontier
Deal found 3/21$260
This CheapOair deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/38:14 pm
DSM
-
PHX
1 stop17h 31m
Frontier
Sun 4/59:24 pm
PHX
-
DSM
1 stop19h 50m
Frontier
Deal found 3/24$261
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/142:38 pm
DSM
-
PHX
Nonstop3h 09m
American Airlines
Wed 4/158:54 am
PHX
-
DSM
Nonstop2h 53m
American Airlines
Deal found 3/23$263
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
-
PHX
1 stop13h 38m
Frontier
Mon 5/1811:26 am
PHX
-
DSM
2 stops48h 05m
Frontier
Deal found 3/22$264
This Expedia deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:16 pm
DSM
-
PHX
1 stop11h 15m
Frontier
Fri 5/225:15 am
PHX
-
DSM
1 stop6h 16m
Frontier
Deal found 3/25$266

Find flight deals from Des Moines to Mesa

Keep the following information in mind while searching for Des Moines to Mesa flight deals. Data was last updated March 26, 2026.

Round-trip from

$245
(Frontier)

One-way from

$67
(Kiwi.com)

Popular in

March

Cheapest in

October

Average price

$384
From Des Moines to Mesa
Search Deals
One-way flight from Des Moines to Mesa
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($38 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Des Moines to Mesa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Tue 5/5

3:15 pm-8:50 pm

2 stops7h 35m

Phoenix Sky Harbor Intl

Thu 5/7

1:55 pm-6:35 pm

Nonstop2h 40m

$274

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Fri 5/1

1:45 pm-2:40 pm

Nonstop2h 55m

Phoenix Sky Harbor Intl

Mon 5/4

2:05 pm-9:55 pm

1 stop5h 50m

$345

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Fri 5/22

4:20 pm-11:30 pm

1 stop9h 10m

Phoenix Sky Harbor Intl

Sat 5/30

1:25 pm-8:55 pm

1 stop5h 30m

$347

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Tue 6/9

6:43 am-10:50 am

1 stop6h 07m

Phoenix Sky Harbor Intl

Fri 6/12

12:41 am-10:14 am

1 stop7h 33m

$349

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Wed 5/6

3:15 pm-9:40 pm

2 stops8h 25m

Phoenix Sky Harbor Intl

Wed 5/13

2:35 pm-9:15 pm

1 stop4h 40m

$354

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Mon 4/27

2:44 pm-10:44 pm

1 stop10h 00m

Phoenix Sky Harbor Intl

Sat 5/2

5:30 pm-10:16 am

2 stops14h 46m

$375
Quickest round-trip

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Fri 4/17

1:45 pm-2:40 pm

Nonstop2h 55m

Phoenix Sky Harbor Intl

Mon 4/20

1:55 pm-6:35 pm

Nonstop2h 40m

$380

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Thu 4/30

7:05 pm-11:53 pm

1 stop6h 48m

Phoenix Sky Harbor Intl

Sat 5/2

9:50 am-4:15 pm

1 stop4h 25m

$384

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Thu 9/17

3:50 pm-7:55 pm

1 stop6h 05m

Phoenix Sky Harbor Intl

Sat 9/19

12:35 am-11:35 am

1 stop9h 00m

$424

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Fri 8/28

7:00 am-12:20 pm

2 stops7h 20m

Phoenix Sky Harbor Intl

Mon 8/31

8:05 am-3:10 pm

1 stop5h 05m

$424

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/25

Showing 1-10 of 21 resultsSorted by cheapest first
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Best time to book a flight from Des Moines to Mesa

Have a flexible travel schedule? Discover the best time to fly to Mesa from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mesa

How far ahead should I book a flight from Des Moines to Mesa?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Mesa. Price data was last updated on March 13, 2026.

To ensure you get the cheapest price possible for a flight from Des Moines to Mesa, you should look to book at least 53 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Des Moines to Mesa?

Currently, December is the cheapest month in which you can book a flight from Des Moines to Mesa (average of $54). Flying from Des Moines to Mesa in February is currently the most expensive (average of $207). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to MS9?

Find hourly flight availability from Des Moines to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 26, 2026.

One of the essential ways to save on airfare from Des Moines to Mesa is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight at noon could potentially save you up to 40% on airfare.

Weekly flight availability from Des Moines to Mesa

Explore weekly flight availability from Des Moines to Mesa. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated March 26, 2026.

The most flights from DSM to MS9 are scheduled on a Monday (7 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (4 on average).

How much does it cost to fly round-trip from Des Moines to Mesa?

Reviews of airlines servicing Mesa

Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated March 26, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAllegiant Air from Des Moines to Mesa. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,331 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,331 reviews
Southwest
8.0
Very good
4,331 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
United Airlines
7.4
Good
9,487 reviews
Southwest
8.0
Very good
4,331 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Allegiant Air
7.3
Good
710 reviews
Southwest
8.0
Very good
4,331 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,496 reviews
Southwest
8.0
Very good
4,331 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Frontier
5.7
Fair
3,015 reviews
Southwest
8.0
Very good
4,331 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mesa?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Mesa from Des Moines. Booking flights from Des Moines (DSM) to Mesa should be relatively easy as there are 5 daily outbound flights to Mesa from 7 different airlines.

  • How long is the flight from Des Moines to Mesa?

    For as low as $349, Southwest can have you in Mesa from Des Moines in 6h 07m. The distance between Des Moines and Mesa is about 1147 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Des Moines to Mesa one-way?

    $84 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on American Airlines and Southwest, with prices starting from $89 and $109, respectively.

  • What are the most reliable airlines from Des Moines to Mesa?

    Before booking your flight to Mesa from Des Moines, check out the most reliable airlines to get you to your destination on time: Frontier (100%), American Airlines (80%), Alaska Airlines( 79%).

  • What are the cheapest flights from Des Moines to Mesa?

    Looking at all options, your cheapest flight can be booked for $88. While the most popular route (Des Moines - Phoenix Sky Harbor Intl) can be booked for $200 on average, our data indicates $335 when flying from Des Moines to Mesa.

  • Can I find deals for flights from Des Moines to Mesa that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mesa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mesa.

  • Can I find deals for business class flights from Des Moines to Mesa?

    Yes. Cheapflights offers flight deals from Des Moines to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mesa?

    Currently, December is the cheapest month in which you can book a flight from Des Moines to Mesa (average of $54). Flying from Des Moines to Mesa in February is currently the most expensive (average of $207). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 7 airlines flying from Des Moines to Mesa

Discover the top 7 airlines that operate flights from Des Moines to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$112Average$234FlexibilityNo cancel feeOn-time88%
FrontierCheapest$160Average$288FlexibilityNo cancel feeOn-time62%
SouthwestCheapest$180Average$346FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$194Average$340FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$212Average$391FlexibilityNo cancel feeOn-time69%
DeltaCheapest$216Average$287FlexibilityNo cancel feeOn-timeN/A
JetBlueCheapest$219Average$328FlexibilityNo cancel feeOn-time62%

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