$61+ Cheap flights from Des Moines (DSM) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/21. Fares are subject to change and may not be available on all flights or dates of travel.
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Mesa
Cheapest flights from Des Moines to MesaExplore the most affordable flight options available from Des Moines to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.
Explore the most affordable flight options available from Des Moines to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Southwest deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Trip.com deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Find flight deals from Des Moines to Mesa
Keep the following information in mind while searching for Des Moines to Mesa flight deals. Data was last updated January 20, 2026.
Round-trip from | $225 (Kiwi.com) |
|---|---|
One-way from | $61 (Frontier) |
Popular in | March |
Cheapest in | October |
Average price | $309 |
Cheapflights Fare Finder
Use the filters below to find and compare flights from Des Moines to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Wed 3/25
5:20 pm-10:49 pm
1 stop7h 29m
Phoenix Sky Harbor Intl
Tue 3/31
11:55 pm-10:48 am
1 stop8h 53m
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Tue 3/17
10:28 am-6:18 pm
1 stop9h 50m
Phoenix Sky Harbor Intl
Fri 3/27
11:05 pm-9:59 am
1 stop8h 54m
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Wed 4/8
4:25 pm-9:52 pm
1 stop7h 27m
Phoenix Sky Harbor Intl
Sun 4/12
11:59 pm-10:18 am
1 stop8h 19m
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Wed 2/25
3:20 pm-10:25 pm
1 stop8h 05m
Phoenix Sky Harbor Intl
Wed 3/4
8:55 am-7:20 pm
2 stops9h 25m
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Tue 3/3
5:15 pm-11:42 pm
1 stop7h 27m
Phoenix Sky Harbor Intl
Mon 3/9
11:05 pm-9:46 am
1 stop8h 41m
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Tue 3/3
5:24 am-12:29 pm
1 stop8h 05m
Phoenix Sky Harbor Intl
Sun 3/8
11:59 pm-10:09 am
1 stop8h 10m
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Wed 3/4
5:15 pm-11:42 pm
1 stop7h 27m
Phoenix Sky Harbor Intl
Mon 3/9
11:55 pm-10:48 am
1 stop8h 53m
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Tue 2/24
4:20 pm-9:17 pm
1 stop5h 57m
Phoenix Sky Harbor Intl
Fri 3/6
7:10 am-3:40 pm
1 stop7h 30m
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Fri 2/27
5:15 pm-11:42 pm
1 stop7h 27m
Phoenix Sky Harbor Intl
Mon 3/2
12:59 am-10:17 am
1 stop8h 18m
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Wed 2/18
5:15 pm-11:42 pm
1 stop7h 27m
Phoenix Sky Harbor Intl
Mon 2/23
11:59 pm-9:56 am
1 stop8h 57m
Best time to book a flight from Des Moines to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Des Moines with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mesa
How far ahead should I book a flight from Des Moines to Mesa?
Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Mesa. Price data was last updated on January 16, 2026.
To ensure you get the cheapest price possible for a flight from Des Moines to Mesa, you should look to book at least 54 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Des Moines to Mesa?
Currently, December is the cheapest month in which you can book a flight from Des Moines to Mesa (average of $54). Flying from Des Moines to Mesa in February is currently the most expensive (average of $163). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DSM to MS9?
Find hourly flight availability from Des Moines to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 20, 2026.
One of the essential ways to save on airfare from Des Moines to Mesa is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight at noon could potentially save you up to 39% on airfare.
Weekly flight availability from Des Moines to Mesa
Explore weekly flight availability from Des Moines to Mesa. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated January 20, 2026.
The most flights from DSM to MS9 are scheduled on a Monday (7 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (4 on average).
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated January 20, 2026.
Read reviews from past customers who have flown Southwest, United Airlines, and American Airlines from Des Moines to Mesa. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
Crew
Food
Overall
Comfort
Entertainment
Reviews
Thomas,Dec 2025
SEA - DEN
Boarding
Crew
Food
Overall
Comfort
Entertainment
Reviews
Thomas,Dec 2025
SEA - DEN
Boarding
Crew
Food
Overall
Comfort
Entertainment
Reviews
Thomas,Dec 2025
SEA - DEN
Boarding
Crew
Food
Overall
Comfort
Entertainment
Reviews
Thomas,Dec 2025
SEA - DEN
Boarding
Crew
Food
Overall
Comfort
Entertainment
Reviews
Thomas,Dec 2025
SEA - DEN
Boarding
Crew
Food
Overall
Comfort
Entertainment
Reviews
Thomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mesa
See prices for flight routes from nearby airports that may be better suited for you.
Top 7 airlines flying from Des Moines to Mesa
Discover the top 7 airlines that operate flights from Des Moines to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$112 | Average$210 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$125 | Average$252 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$187 | Average$352 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$190 | Average$343 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$213 | Average$404 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$216 | Average$287 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$219 | Average$310 | FlexibilityNo cancel fee | On-time62% |