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$73+ Cheap flights from Des Moines (DSM) to Mesa, AZ

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/19. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PHX
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Mesa are usually found in January or November, booked 83 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from Des Moines to Mesa

Keep the following information in mind while searching for Des Moines to Mesa flight deals. Data was last updated August 14, 2025.

Round-trip from

$197
(Priceline)

One-way from

$73
(Priceline)

Popular in

March

Cheapest in

January

Average price

$313
From Des Moines to Mesa
Search Deals
One-way flight from Des Moines to Mesa
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Highest demand for flights based on searches. 11% potential increase in price ($42 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Des Moines to Mesa

Cheapest flights from Des Moines to Mesa
Explore the most affordable flight options available from Des Moines to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This Priceline deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/222:25 pmDSM - PHX
1 stop7h 00mFrontier
Mon 9/297:00 amPHX - DSM
1 stop4h 40mFrontier
Deal found 8/12$197
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/118:06 amDSM - PHX
Nonstop3h 28mAmerican Airlines
Sat 11/158:12 pmPHX - DSM
Nonstop2h 47mAmerican Airlines
Deal found 8/14$201
This FlightHub deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/262:25 pmDSM - PHX
1 stop23h 07mFrontier
Mon 9/297:00 amPHX - DSM
1 stop4h 40mFrontier
Deal found 8/13$202
This Priceline deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/68:44 pmDSM - PHX
1 stop4h 45mFrontier
Mon 11/1012:59 pmPHX - DSM
1 stop6h 00mFrontier
Deal found 8/11$203
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/222:28 pmDSM - PHX
Nonstop3h 07mAmerican Airlines
Wed 10/294:20 pmPHX - DSM
Nonstop2h 56mAmerican Airlines
Deal found 8/14$204
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/155:30 amDSM - PHX
Nonstop3h 13mAmerican Airlines
Wed 10/158:47 amPHX - DSM
Nonstop3h 00mAmerican Airlines
Deal found 8/13$207
This Frontier deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/152:25 pmDSM - PHX
1 stop11h 32mFrontier
Sun 9/218:40 pmPHX - DSM
2 stops15h 00mFrontier
Deal found 8/14$210
This FlightHub deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/152:37 pmDSM - PHX
1 stop9h 18mFrontier
Tue 10/214:14 pmPHX - DSM
1 stop19h 38mFrontier
Deal found 8/12$211
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/262:17 pmDSM - PHX
Nonstop3h 18mAmerican Airlines
Mon 9/297:22 pmPHX - DSM
Nonstop2h 56mAmerican Airlines
Deal found 8/13$212
This FlightHub deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/252:25 pmDSM - PHX
1 stop4h 48mFrontier
Mon 9/297:00 amPHX - DSM
1 stop4h 40mFrontier
Deal found 8/12$213
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/74:10 pmDSM - PHX
Nonstop3h 05mSouthwest
Wed 11/125:45 amPHX - DSM
1 stop4h 40mSouthwest
Deal found 8/13$214

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Des Moines to Mesa that are best for you.

Fly from

Des Moines

Fly to

Mesa

Route

Depart

Return

Price

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Mon 9/22

2:25 pm-7:25 pm

1 stop7h 00m

Phoenix Sky Harbor Intl

Mon 9/29

7:00 am-1:40 pm

1 stop4h 40m

$197

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Wed 10/15

2:28 pm-3:35 pm

Nonstop3h 07m

Phoenix Sky Harbor Intl

Tue 10/21

8:47 am-1:47 pm

Nonstop3h 00m

$201

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Sat 10/4

12:55 pm-2:00 pm

Nonstop3h 05m

Phoenix Sky Harbor Intl

Tue 10/7

11:20 am-4:00 pm

Nonstop2h 40m

$201

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Tue 11/11

8:06 am-10:34 am

Nonstop3h 28m

Phoenix Sky Harbor Intl

Sat 11/15

8:12 pm-11:59 pm

Nonstop2h 47m

$201

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Wed 10/22

2:28 pm-3:35 pm

Nonstop3h 07m

Phoenix Sky Harbor Intl

Wed 10/29

8:47 am-1:47 pm

Nonstop3h 00m

$201

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Fri 10/31

2:28 pm-3:35 pm

Nonstop3h 07m

Phoenix Sky Harbor Intl

Tue 11/4

8:12 pm-11:59 pm

Nonstop2h 47m

$201

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Wed 9/10

2:17 pm-3:35 pm

Nonstop3h 18m

Phoenix Sky Harbor Intl

Wed 9/17

7:22 pm-12:18 am

Nonstop2h 56m

$201

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Fri 9/26

2:25 pm-11:32 am

1 stop23h 07m

Phoenix Sky Harbor Intl

Mon 9/29

7:00 am-1:40 pm

1 stop4h 40m

$202

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Thu 11/6

8:44 pm-12:29 am

1 stop4h 45m

Phoenix Sky Harbor Intl

Mon 11/10

12:59 pm-7:59 pm

1 stop6h 00m

$203

Des MoinesPhoenix

DSM - PHX

DSMPHX

Des Moines

Wed 9/17

2:17 pm-3:35 pm

Nonstop3h 18m

Phoenix Sky Harbor Intl

Wed 9/24

7:22 pm-12:18 am

Nonstop2h 56m

$204

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 22 results
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2
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Best time to book a flight from Des Moines to Mesa

Have a flexible travel schedule? Discover the best time to fly to Mesa from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mesa

How far ahead should I book a flight from Des Moines to Mesa?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Mesa. Price data was last updated on August 8, 2025.

To ensure you get the cheapest price possible for a flight from Des Moines to Mesa, you should look to book at least 83 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Des Moines to Mesa?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Mesa (average of $258). Flying from Des Moines to Mesa in March is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to MS9?

Find hourly flight availability from Des Moines to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Mesa as you normally would.

What is the cheapest day to fly from Des Moines to Mesa?

Use this chart to determine the cheapest time to fly round-trip from Des Moines to Mesa. Price data was last updated on August 10, 2025.

Travelers seeking maximum savings on their Des Moines to Mesa flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Des Moines to Mesa

Explore weekly flight availability from Des Moines to Mesa. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 14, 2025.

The most flights from DSM to MS9 are scheduled on a Thursday (6 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (4 on average).

Reviews of airlines servicing Mesa

Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated August 14, 2025.
Read reviews from past customers who have flown Southwest, United Airlines, and American Airlines from Des Moines to Mesa. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,244 reviews
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,916 reviews
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Allegiant Air
7.2
Good
701 reviews
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Frontier
5.8
Fair
3,219 reviews
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mesa?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Mesa from Des Moines. Booking flights from Des Moines (DSM) to Mesa should be relatively easy as there are 4 daily outbound flights to Mesa from 6 different airlines.

  • What are the most reliable airlines from Des Moines to Mesa?

    Before booking your flight to Mesa from Des Moines, check out the most reliable airlines to get you to your destination on time: Envoy Air (100%), Alaska Airlines (95%), American Airlines( 95%).

  • What are the cheapest flights from Des Moines to Mesa?

    Looking at all options, your cheapest flight can be booked for $100. While the most popular route (Des Moines - Phoenix Sky Harbor Intl) can be booked for $209 on average our data indicates $501 when flying from Des Moines to Mesa.

  • Can I find deals for flights from Des Moines to Mesa that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mesa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mesa.

  • Can I find deals for business class flights from Des Moines to Mesa?

    Yes. Cheapflights offers flight deals from Des Moines to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mesa?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Mesa (average of $258). Flying from Des Moines to Mesa in March is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 6 airlines flying from Des Moines to Mesa

Discover the top 6 airlines that operate flights from Des Moines to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$106Average$248FlexibilityNo cancel feeOn-time62%
Allegiant AirCheapest$120Average$224FlexibilityNo cancel feeOn-time88%
SouthwestCheapest$198Average$330FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$200Average$350FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$216Average$408FlexibilityNo cancel feeOn-time69%
DeltaCheapest$236Average$317FlexibilityNo cancel feeOn-timeN/A

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