$49+ Cheap flights from Des Moines (DSM) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PHX
Apr 4 — Apr 111
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to Mesa are usually found in October or August, booked 53 days in advance, depart on a Wednesday or Saturday and return on a Tuesday
Cheap flight deals from Des Moines to Mesa
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to MesaExplore the most affordable flight options available from Des Moines to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 5, 2026.
Explore the most affordable flight options available from Des Moines to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 5, 2026.
This Frontier deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:14 pm
DSM
- PHX
1 stop5h 43m
Frontier
Fri 4/1012:50 pm
PHX
- DSM
1 stop4h 24m
Frontier
Deal found 3/1![Frontier logo]()
$236
This Delta deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:44 pm
DSM
- PHX
1 stop10h 00m
Delta
Tue 5/1212:57 am
PHX
- DSM
1 stop7h 19m
Delta
Deal found 3/1![Delta logo]()
$239
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:40 am
DSM
- PHX
1 stop5h 45m
Southwest
Wed 5/61:40 pm
PHX
- DSM
1 stop5h 35m
Southwest
Deal found 3/1![Southwest logo]()
$240
This Frontier deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:00 am
DSM
- PHX
1 stop14h 44m
Frontier
Sat 3/149:30 am
PHX
- DSM
Nonstop2h 41m
Frontier
Deal found 2/28![Frontier logo]()
$241
This Frontier deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:27 pm
DSM
- PHX
1 stop6h 14m
Frontier
Sat 3/149:30 am
PHX
- DSM
Nonstop2h 41m
Frontier
Deal found 2/28![Frontier logo]()
$242
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:38 pm
DSM
- PHX
Nonstop3h 09m
American Airlines
Wed 5/138:54 am
PHX
- DSM
Nonstop2h 53m
American Airlines
Deal found 2/28![American Airlines logo]()
$244
This Trip.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:04 pm
DSM
- PHX
1 stop8h 12m
Frontier
Fri 4/246:50 am
PHX
- DSM
1 stop4h 19m
Frontier
Deal found 3/3![Frontier logo]()
$247
This Super.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/98:21 pm
DSM
- PHX
1 stop5h 30m
Frontier
Sat 3/149:30 am
PHX
- DSM
Nonstop2h 41m
Frontier
Deal found 3/4![Frontier logo]()
$248
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:23 pm
DSM
- PHX
Nonstop3h 12m
American Airlines
Wed 4/88:54 am
PHX
- DSM
Nonstop2h 53m
American Airlines
Deal found 3/3![American Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:30 am
DSM
- PHX
2 stops42h 38m
Multiple Airlines
Wed 3/256:50 am
PHX
- DSM
1 stop10h 26m
Multiple Airlines
Deal found 3/2![Multiple Airlines logo]()
$250
Best flights from Des Moines to MesaDiscover carefully curated flight deals from Des Moines to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 5, 2026.
Discover carefully curated flight deals from Des Moines to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 5, 2026.
This Southwest deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:05 pm
DSM
- PHX
1 stop6h 55m
Southwest
Wed 5/611:35 am
PHX
- DSM
2 stops7h 40m
Southwest
Deal found 2/28![Southwest logo]()
$245
This United Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:17 pm
DSM
- PHX
1 stop5h 02m
United Airlines
Tue 4/211:30 pm
PHX
- DSM
2 stops8h 12m
United Airlines
Deal found 3/1![United Airlines logo]()
$294
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/95:35 am
DSM
- PHX
1 stop9h 55m
Delta
Tue 4/1411:05 pm
PHX
- DSM
1 stop8h 49m
Delta
Deal found 3/4![Delta logo]()
$334
This Southwest deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/287:55 pm
DSM
- PHX
Nonstop3h 05m
Southwest
Sat 4/42:35 pm
PHX
- DSM
Nonstop2h 40m
Southwest
Deal found 2/28![Southwest logo]()
$250
This Southwest deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/11:45 pm
DSM
- PHX
Nonstop2h 55m
Southwest
Tue 5/510:20 am
PHX
- DSM
1 stop5h 35m
Southwest
Deal found 2/28![Southwest logo]()
$289
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:55 am
DSM
- PHX
1 stop4h 40m
Southwest
Wed 4/222:35 pm
PHX
- DSM
1 stop4h 40m
Southwest
Deal found 3/1![Southwest logo]()
$289
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/84:25 pm
DSM
- PHX
1 stop7h 27m
Delta
Fri 4/1011:55 pm
PHX
- DSM
1 stop8h 53m
Delta
Deal found 3/4![Delta logo]()
$381
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2512:15 pm
DSM
- PHX
1 stop6h 30m
Southwest
Sat 3/282:35 pm
PHX
- DSM
Nonstop2h 40m
Southwest
Deal found 3/3![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/241:45 pm
DSM
- PHX
Nonstop2h 55m
Southwest
Mon 5/41:55 pm
PHX
- DSM
Nonstop2h 40m
Southwest
Deal found 3/3![Southwest logo]()
$339
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/304:20 pm
DSM
- PHX
1 stop7h 45m
Southwest
Thu 4/211:00 am
PHX
- DSM
Nonstop2h 40m
Southwest
Deal found 3/1![Southwest logo]()
$339
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/141:45 pm
DSM
- PHX
Nonstop2h 55m
Southwest
Sun 5/1711:55 pm
PHX
- DSM
1 stop9h 50m
Southwest
Deal found 3/3![Southwest logo]()
$366
Last-minute flights from Des Moines to MesaDiscover last-minute flight deals from Des Moines to Mesa. Data last updated March 5, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mesa. Data last updated March 5, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- PHX
1 stop19h 40m
Frontier
Sat 3/149:30 am
PHX
- DSM
Nonstop2h 41m
Frontier
Deal found 3/2![Frontier logo]()
$240
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/98:21 pm
DSM
- PHX
1 stop5h 30m
Frontier
Mon 3/1611:17 am
PHX
- DSM
Nonstop2h 41m
Frontier
Deal found 3/3![Frontier logo]()
$244
This Frontier deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/98:21 pm
DSM
- PHX
1 stop5h 30m
Frontier
Sat 3/149:30 am
PHX
- DSM
Nonstop2h 41m
Frontier
Deal found 3/4![Frontier logo]()
$248
This Expedia deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:00 am
DSM
- PHX
1 stop14h 44m
Frontier
Sat 3/149:30 am
PHX
- DSM
Nonstop2h 41m
Frontier
Deal found 2/28![Frontier logo]()
$241
This Frontier deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/118:21 pm
DSM
- PHX
1 stop5h 30m
Frontier
Sat 3/149:30 am
PHX
- DSM
Nonstop2h 41m
Frontier
Deal found 3/1![Frontier logo]()
$242
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/118:21 pm
DSM
- PHX
1 stop5h 30m
Frontier
Mon 3/1611:17 am
PHX
- DSM
Nonstop2h 41m
Frontier
Deal found 3/3![Frontier logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:30 am
DSM
- PHX
2 stops42h 38m
Multiple Airlines
Wed 3/256:50 am
PHX
- DSM
1 stop10h 26m
Multiple Airlines
Deal found 3/2![Multiple Airlines logo]()
$250
This Frontier deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:43 pm
DSM
- PHX
Nonstop3h 20m
Frontier
Mon 3/306:50 am
PHX
- DSM
1 stop10h 26m
Frontier
Deal found 3/2![Frontier logo]()
$239
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:23 pm
DSM
- PHX
Nonstop3h 12m
American Airlines
Wed 4/88:54 am
PHX
- DSM
Nonstop2h 53m
American Airlines
Deal found 3/3![American Airlines logo]()
$249
This Frontier deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:14 pm
DSM
- PHX
1 stop5h 43m
Frontier
Fri 4/1012:50 pm
PHX
- DSM
1 stop4h 24m
Frontier
Deal found 3/1![Frontier logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/108:14 pm
DSM
- PHX
2 stops17h 09m
Frontier
Sun 4/129:24 pm
PHX
- DSM
1 stop19h 50m
Frontier
Deal found 3/3![Frontier logo]()
$252
This Trip.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:04 pm
DSM
- PHX
1 stop8h 12m
Frontier
Fri 4/246:50 am
PHX
- DSM
1 stop4h 19m
Frontier
Deal found 3/3![Frontier logo]()
$247
One-way flights from Des Moines to MesaSearch for one-way flight options from Des Moines to Mesa. Find affordable one-way fares based on user searches. Data last updated March 5, 2026.
Search for one-way flight options from Des Moines to Mesa. Find affordable one-way fares based on user searches. Data last updated March 5, 2026.
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/212:56 pm
DSM
- PHX
Nonstop3h 20m
Frontier
Deal found 3/3![Frontier logo]()
$49
This Super.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/185:41 pm
DSM
- PHX
Nonstop3h 20m
Frontier
Deal found 3/3![Frontier logo]()
$64
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- PHX
1 stop29h 43m
Frontier
Deal found 3/3![Frontier logo]()
$78
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/38:14 pm
DSM
- PHX
1 stop23h 33m
Frontier
Deal found 3/3![Frontier logo]()
$82
This Super.com deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/108:14 pm
DSM
- PHX
1 stop5h 33m
Frontier
Deal found 2/28![Frontier logo]()
$89
This Frontier deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
- PHX
1 stop5h 19m
Frontier
Deal found 3/4![Frontier logo]()
$90
This CheapOair deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/38:21 pm
DSM
- PHX
1 stop23h 02m
Frontier
Deal found 3/4![Frontier logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/32:51 pm
DSM
- PHX
1 stop22h 12m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$105
Find flight deals from Des Moines to Mesa
Keep the following information in mind while searching for Des Moines to Mesa flight deals. Data was last updated March 5, 2026.
Round-trip from | $236 (Frontier) |
|---|---|
One-way from | $49 (Frontier) |
Popular in | March |
Cheapest in | October |
Average price | $385 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 5, 2026.
Use the filters below to find and compare flights from Des Moines to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Sat 5/2
12:05 pm-5:00 pm
1 stop6h 55m
Phoenix Sky Harbor Intl
Wed 5/6
11:35 am-9:15 pm
2 stops7h 40m
$245
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Sat 3/28
7:55 pm-9:00 pm
Nonstop3h 05m
Phoenix Sky Harbor Intl
Sat 4/4
2:35 pm-7:15 pm
Nonstop2h 40m
$250
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Fri 5/1
1:45 pm-2:40 pm
Nonstop2h 55m
Phoenix Sky Harbor Intl
Tue 5/5
10:20 am-5:55 pm
1 stop5h 35m
$289
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Wed 4/15
6:55 am-9:35 am
1 stop4h 40m
Phoenix Sky Harbor Intl
Wed 4/22
2:35 pm-9:15 pm
1 stop4h 40m
$289
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Wed 4/15
5:17 pm-8:19 pm
1 stop5h 02m
Phoenix Sky Harbor Intl
Tue 4/21
1:30 pm-11:42 pm
2 stops8h 12m
$294
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Wed 3/25
12:15 pm-4:45 pm
1 stop6h 30m
Phoenix Sky Harbor Intl
Sat 3/28
2:35 pm-7:15 pm
Nonstop2h 40m
$299
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Thu 4/9
5:35 am-1:30 pm
1 stop9h 55m
Phoenix Sky Harbor Intl
Tue 4/14
11:05 pm-9:54 am
1 stop8h 49m
$334
Quickest round-trip
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Fri 4/24
1:45 pm-2:40 pm
Nonstop2h 55m
Phoenix Sky Harbor Intl
Mon 5/4
1:55 pm-6:35 pm
Nonstop2h 40m
$339
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Mon 3/30
4:20 pm-10:05 pm
1 stop7h 45m
Phoenix Sky Harbor Intl
Thu 4/2
11:00 am-3:40 pm
Nonstop2h 40m
$339
Des MoinesPhoenix
DSM - PHX
DSMPHX
Des Moines
Thu 5/14
1:45 pm-2:40 pm
Nonstop2h 55m
Phoenix Sky Harbor Intl
Sun 5/17
11:55 pm-11:45 am
1 stop9h 50m
$366
Showing 1-10 of 20 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Des Moines with our price prediction graph.
DSM-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mesa
DSM-MS9
DSM-PHX
How far ahead should I book a flight from Des Moines to Mesa?
Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Mesa. Price data was last updated on February 27, 2026.
To ensure you get the cheapest price possible for a flight from Des Moines to Mesa, you should look to book at least 53 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Des Moines to Mesa?
Currently, December is the cheapest month in which you can book a flight from Des Moines to Mesa (average of $54). Flying from Des Moines to Mesa in February is currently the most expensive (average of $162). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DSM to MS9?
Find hourly flight availability from Des Moines to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 5, 2026.
One of the essential ways to save on airfare from Des Moines to Mesa is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight at noon could potentially save you up to 44% on airfare.
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated March 5, 2026.
Read reviews from past customers who have flown Southwest, United Airlines, and Allegiant Air from Des Moines to Mesa. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.0
Entertainment
7.5
Crew
8.6
Comfort
8.0
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Food
7.0
Entertainment
7.5
Crew
8.6
Comfort
8.0
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Food
7.0
Entertainment
7.5
Crew
8.6
Comfort
8.0
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Food
7.0
Entertainment
7.5
Crew
8.6
Comfort
8.0
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Food
7.0
Entertainment
7.5
Crew
8.6
Comfort
8.0
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Food
7.0
Entertainment
7.5
Crew
8.6
Comfort
8.0
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Top 7 airlines flying from Des Moines to Mesa
Discover the top 7 airlines that operate flights from Des Moines to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$111 | Average$227 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$148 | Average$272 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$187 | Average$346 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$190 | Average$337 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$212 | Average$390 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$216 | Average$287 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$219 | Average$328 | FlexibilityNo cancel fee | On-time62% |