$144+ Cheap flights from Des Moines to Louisville (DSM - SDF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDF
May 4 — May 111
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Louisville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Louisville
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Best
Last-minute
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Cheapest flights from Des Moines to LouisvilleExplore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2026.
Explore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2026.
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/63:15 pm
DSM
- SDF
1 stop4h 20m
Southwest
Thu 5/78:40 am
SDF
- DSM
1 stop4h 05m
Southwest
Deal found 4/2![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/74:20 pm
DSM
- SDF
1 stop3h 40m
Southwest
Sat 5/98:40 am
SDF
- DSM
1 stop3h 50m
Southwest
Deal found 3/31![Southwest logo]()
$301
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:39 pm
DSM
- SDF
1 stop4h 53m
Delta
Fri 7/37:05 am
SDF
- DSM
1 stop4h 52m
Delta
Deal found 3/31![Delta logo]()
$317
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:48 pm
DSM
- SDF
2 stops7h 39m
American Airlines
Fri 7/38:19 pm
SDF
- DSM
1 stop4h 47m
American Airlines
Deal found 3/31![American Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/74:20 pm
DSM
- SDF
1 stop3h 40m
Southwest
Sun 5/108:20 pm
SDF
- DSM
1 stop4h 00m
Southwest
Deal found 3/31![Southwest logo]()
$329
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:25 am
DSM
- SDF
1 stop3h 30m
Southwest
Fri 5/85:25 pm
SDF
- DSM
2 stops6h 40m
Southwest
Deal found 4/1![Southwest logo]()
$334
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2211:57 am
DSM
- SDF
1 stop6h 06m
Delta
Mon 5/256:05 am
SDF
- DSM
1 stop5h 11m
Delta
Deal found 4/1![Delta logo]()
$347
This Southwest deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/194:40 pm
DSM
- SDF
2 stops6h 45m
Southwest
Wed 6/247:45 pm
SDF
- DSM
1 stop4h 00m
Southwest
Deal found 4/3![Southwest logo]()
$352
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/53:20 pm
DSM
- SDF
1 stop3h 57m
United Airlines
Wed 5/65:40 am
SDF
- DSM
1 stop5h 57m
United Airlines
Deal found 4/1![United Airlines logo]()
$357
Best flights from Des Moines to LouisvilleDiscover carefully curated flight deals from Des Moines to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 4, 2026.
Discover carefully curated flight deals from Des Moines to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 4, 2026.
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:30 am
DSM
- SDF
1 stop3h 20m
Southwest
Thu 5/75:25 pm
SDF
- DSM
2 stops6h 40m
Southwest
Deal found 4/2![Southwest logo]()
$304
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:39 pm
DSM
- SDF
1 stop4h 53m
Delta
Fri 7/37:05 am
SDF
- DSM
1 stop4h 52m
Delta
Deal found 3/31![Delta logo]()
$317
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:05 pm
DSM
- SDF
1 stop3h 51m
United Airlines
Wed 5/611:11 am
SDF
- DSM
1 stop4h 13m
United Airlines
Deal found 4/2![United Airlines logo]()
$357
This Southwest deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:55 am
DSM
- SDF
2 stops7h 10m
Southwest
Sun 5/108:20 pm
SDF
- DSM
1 stop4h 00m
Southwest
Deal found 4/3![Southwest logo]()
$322
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:20 am
DSM
- SDF
1 stop6h 18m
Delta
Sun 10/46:36 am
SDF
- DSM
1 stop4h 39m
Delta
Deal found 3/30![Delta logo]()
$347
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/74:20 pm
DSM
- SDF
1 stop3h 40m
Southwest
Fri 5/88:40 am
SDF
- DSM
1 stop4h 05m
Southwest
Deal found 4/1![Southwest logo]()
$329
This Southwest deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/194:40 pm
DSM
- SDF
2 stops6h 45m
Southwest
Wed 6/247:45 pm
SDF
- DSM
1 stop4h 00m
Southwest
Deal found 4/3![Southwest logo]()
$352
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:50 am
DSM
- SDF
2 stops13h 10m
Southwest
Sat 5/98:40 am
SDF
- DSM
1 stop3h 50m
Southwest
Deal found 3/31![Southwest logo]()
$360
Last-minute flights from Des Moines to LouisvilleDiscover last-minute flight deals from Des Moines to Louisville. Data last updated April 4, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Louisville. Data last updated April 4, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:30 am
DSM
- SDF
1 stop3h 20m
Southwest
Sun 5/108:20 pm
SDF
- DSM
1 stop4h 00m
Southwest
Deal found 4/3![Southwest logo]()
$317
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/53:20 pm
DSM
- SDF
1 stop3h 57m
United Airlines
Wed 5/65:40 am
SDF
- DSM
1 stop5h 57m
United Airlines
Deal found 4/1![United Airlines logo]()
$357
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/63:15 pm
DSM
- SDF
1 stop4h 20m
Southwest
Thu 5/78:40 am
SDF
- DSM
1 stop4h 05m
Southwest
Deal found 4/2![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/74:20 pm
DSM
- SDF
1 stop3h 40m
Southwest
Sat 5/98:40 am
SDF
- DSM
1 stop3h 50m
Southwest
Deal found 3/31![Southwest logo]()
$301
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/74:20 pm
DSM
- SDF
1 stop3h 40m
Southwest
Sun 5/108:20 pm
SDF
- DSM
1 stop4h 00m
Southwest
Deal found 3/31![Southwest logo]()
$329
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:25 am
DSM
- SDF
1 stop3h 30m
Southwest
Fri 5/85:25 pm
SDF
- DSM
2 stops6h 40m
Southwest
Deal found 4/1![Southwest logo]()
$334
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2211:57 am
DSM
- SDF
1 stop6h 06m
Delta
Mon 5/256:05 am
SDF
- DSM
1 stop5h 11m
Delta
Deal found 4/1![Delta logo]()
$347
One-way flights from Des Moines to LouisvilleSearch for one-way flight options from Des Moines to Louisville. Find affordable one-way fares based on user searches. Data last updated April 4, 2026.
Search for one-way flight options from Des Moines to Louisville. Find affordable one-way fares based on user searches. Data last updated April 4, 2026.
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:30 am
DSM
- SDF
1 stop3h 20m
Southwest
Deal found 3/31![Southwest logo]()
$144
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:01 am
DSM
- SDF
1 stop3h 58m
Delta
Deal found 4/1![Delta logo]()
$146
This Southwest deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:25 am
DSM
- SDF
1 stop3h 30m
Southwest
Deal found 4/3![Southwest logo]()
$156
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:35 am
DSM
- SDF
2 stops17h 00m
Southwest
Deal found 4/1![Southwest logo]()
$162
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/13:20 pm
DSM
- SDF
1 stop3h 57m
United Airlines
Deal found 4/4![United Airlines logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- SDF
3 stops44h 26m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$200
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:20 am
DSM
- SDF
2 stops15h 20m
Southwest
Deal found 3/30![Southwest logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/110:59 am
DSM
- SDF
3 stops22h 33m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$265
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/912:00 pm
DSM
- SDF
1 stop5h 30m
American Airlines
Deal found 4/1![American Airlines logo]()
$289
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/95:25 am
DSM
- SDF
2 stops10h 25m
Southwest
Deal found 4/1![Southwest logo]()
$294
Find flight deals from Des Moines to Louisville
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $299 (Southwest) |
One-way from | $129 (Kiwi.com) |
Popular in | December |
Cheapest in | January |
Average price | $356 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2026.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Wed 5/6
5:30 am-9:50 am
1 stop3h 20m
Louisville Intl
Thu 5/7
5:25 pm-11:05 pm
2 stops6h 40m
$304
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Tue 6/30
6:39 pm-12:32 am
1 stop4h 53m
Louisville Intl
Fri 7/3
7:05 am-10:57 am
1 stop4h 52m
$317
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Tue 5/5
6:55 am-3:05 pm
2 stops7h 10m
Louisville Intl
Sun 5/10
8:20 pm-11:20 pm
1 stop4h 00m
$322
Quickest round-trip
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Thu 5/7
4:20 pm-9:00 pm
1 stop3h 40m
Louisville Intl
Fri 5/8
8:40 am-11:45 am
1 stop4h 05m
$329
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Wed 9/30
6:20 am-1:38 pm
1 stop6h 18m
Louisville Intl
Sun 10/4
6:36 am-10:15 am
1 stop4h 39m
$347
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Fri 6/19
4:40 pm-12:25 am
2 stops6h 45m
Louisville Intl
Wed 6/24
7:45 pm-10:45 pm
1 stop4h 00m
$352
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Tue 5/5
7:05 pm-11:56 pm
1 stop3h 51m
Louisville Intl
Wed 5/6
11:11 am-2:24 pm
1 stop4h 13m
$357
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Thu 5/7
6:50 am-9:00 pm
2 stops13h 10m
Louisville Intl
Sat 5/9
8:40 am-11:30 am
1 stop3h 50m
$360
Cheapest one-way
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Wed 7/1
3:45 pm-8:25 pm
1 stop3h 40m
$144
Quickest one-way
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Wed 4/29
5:30 am-9:50 am
1 stop3h 20m
$144
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Louisville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Louisville in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Louisville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Louisville
Have a flexible travel schedule? Discover the best time to fly to Louisville from Des Moines with our price prediction graph.
DSM-SDF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Louisville
What is the cheapest month to book a flight from Des Moines to Louisville?
Currently, August is the cheapest month in which you can book a flight from Des Moines to Louisville (average of $118). Flying from Des Moines to Louisville in March is currently the most expensive (average of $405). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Louisville?
Reviews of airlines servicing Louisville
Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated April 4, 2026.
Read through reviews of airlines operating flights from Des Moines to Louisville, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Crew
8.5
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Crew
8.5
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Crew
8.5
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Crew
8.5
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Louisville?
Book flights to Louisville if you plan to visit one of these locationsShepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Other flights to Louisville
Explore flights to Louisville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 4, 2026.
Des Moines and Louisville flights
Browse other Des Moines and Louisville flight options. Last updated on April 4, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on April 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Louisville
Discover the top 3 airlines that operate flights from Des Moines to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$129 | Average$298 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$148 | Average$400 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$260 | Average$366 | FlexibilityNo cancel fee | On-time71% |