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$99+ Cheap flights from Des Moines to Louisville (DSM - SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDF
août 19 — août 261
mar. 8/19
mar. 8/26
1 adult, Economy
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Cheap flight deals from Des Moines to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated août 14, 2025.

Round-trip from

$197
(Delta)

One-way from

$99
(Delta)

Popular in

December

Cheapest in

February

Average price

$327
From Des Moines to Louisville Intl
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One-way flight from Des Moines to Louisville Intl
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Highest demand for flights based on searches. 7% potential increase in price ($32 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Des Moines to Louisville

Cheapest flights from Des Moines to Louisville
Explore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on août 14, 2025.

This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/156:30 pmDSM - SDF
1 stop4h 22mDelta
jeu. 9/186:00 amSDF - DSM
1 stop5h 14mDelta
Deal found 8/14$197
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 9/116:30 pmDSM - SDF
1 stop4h 22mDelta
dim. 9/146:00 amSDF - DSM
1 stop5h 14mDelta
Deal found 8/13$208
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven. 9/124:09 pmDSM - SDF
1 stop6h 31mAmerican Airlines
ven. 9/195:18 pmSDF - DSM
1 stop6h 48mAmerican Airlines
Deal found 8/13$219
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 9/114:04 pmDSM - SDF
1 stop6h 30mAmerican Airlines
lun. 9/156:44 pmSDF - DSM
1 stop5h 29mAmerican Airlines
Deal found 8/14$252
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sam. 9/273:25 pmDSM - SDF
1 stop4h 08mUnited Airlines
sam. 10/43:30 pmSDF - DSM
1 stop5h 41mUnited Airlines
Deal found 8/13$257
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 10/25:35 amDSM - SDF
2 stops5h 30mSouthwest
lun. 10/64:35 pmSDF - DSM
1 stop6h 00mSouthwest
Deal found 8/12$262
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 9/186:11 pmDSM - SDF
1 stop4h 48mAmerican Airlines
ven. 9/195:18 pmSDF - DSM
1 stop6h 48mAmerican Airlines
Deal found 8/14$263
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 9/108:25 amDSM - SDF
2 stops5h 50mSouthwest
mer. 9/173:20 pmSDF - DSM
2 stops8h 00mSouthwest
Deal found 8/13$267
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven. 10/35:35 amDSM - SDF
2 stops12h 50mSouthwest
lun. 10/64:35 pmSDF - DSM
1 stop6h 00mSouthwest
Deal found 8/12$269
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 10/236:05 amDSM - SDF
1 stop6h 48mDelta
dim. 10/267:00 amSDF - DSM
1 stop4h 26mDelta
Deal found 8/14$272
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven. 9/121:55 pmDSM - SDF
1 stop8h 45mSouthwest
ven. 9/196:25 amSDF - DSM
2 stops5h 40mSouthwest
Deal found 8/13$290
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/152:22 pmDSM - SDF
2 stops17h 57mMultiple Airlines
jeu. 9/1812:03 pmSDF - DSM
1 stop9h 37mMultiple Airlines
Deal found 8/14$300

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated août 14, 2025.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.

Fly from

Des Moines

Fly to

Louisville

Route

Depart

Return

Price

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

jeu. 10/2

5:00 am-9:24 am

1 stop3h 24m

Louisville Intl

lun. 10/6

5:53 pm-11:23 pm

1 stop6h 30m

$197

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

lun. 9/15

5:25 pm-10:58 pm

1 stop4h 33m

Louisville Intl

jeu. 9/18

6:00 am-10:14 am

1 stop5h 14m

$197

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

sam. 9/27

11:25 am-4:51 pm

1 stop4h 26m

Louisville Intl

sam. 10/4

6:00 am-10:14 am

1 stop5h 14m

$197

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

ven. 10/3

3:25 pm-10:30 pm

1 stop6h 05m

Louisville Intl

lun. 10/6

5:48 pm-9:50 pm

1 stop5h 02m

$208

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

jeu. 9/11

6:30 pm-11:52 pm

1 stop4h 22m

Louisville Intl

dim. 9/14

6:00 am-10:14 am

1 stop5h 14m

$208

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

ven. 9/12

4:09 pm-11:40 pm

1 stop6h 31m

Louisville Intl

ven. 9/19

5:18 pm-11:06 pm

1 stop6h 48m

$219

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

jeu. 9/11

4:04 pm-11:34 pm

1 stop6h 30m

Louisville Intl

lun. 9/15

6:44 pm-11:13 pm

1 stop5h 29m

$252

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

sam. 9/27

3:25 pm-8:33 pm

1 stop4h 08m

Louisville Intl

sam. 10/4

3:30 pm-8:11 pm

1 stop5h 41m

$257

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

sam. 9/27

4:09 pm-11:40 pm

1 stop6h 31m

Louisville Intl

sam. 10/4

1:06 pm-8:21 pm

2 stops8h 15m

$257

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

jeu. 10/2

5:35 am-12:05 pm

2 stops5h 30m

Louisville Intl

lun. 10/6

4:35 pm-9:35 pm

1 stop6h 00m

$262

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Showing 1-10 of 15 results
1
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Best time to book a flight from Des Moines to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Louisville

What is the cheapest month to book a flight from Des Moines to Louisville?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Louisville (average of $299). Flying from Des Moines to Louisville in April is currently the most expensive (average of $369). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Louisville?

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated août 14, 2025.
Read through reviews of airlines operating flights from Des Moines to Louisville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,916 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Louisville round-trip?

    Delta, at $196, was found to be the cheapest airline from Des Moines to Louisville.Alternate airlines to your destination round-trip include American Airlines and United Airlines. Delta is priced at 48% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Louisville one-way?

    $99 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on United Airlines and Southwest, with prices starting from $110 and $170, respectively.

  • Can I find deals for flights from Des Moines to Louisville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Louisville.

  • Can I find deals for business class flights from Des Moines to Louisville?

    Yes. Cheapflights offers flight deals from Des Moines to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Louisville?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Louisville (average of $299). Flying from Des Moines to Louisville in April is currently the most expensive (average of $369). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

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Alternative routes for Des Moines to Louisville

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Top 3 airlines flying from Des Moines to Louisville

Discover the top 3 airlines that operate flights from Des Moines to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated août 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$196Average$307FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$264Average$422FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$306Average$432FlexibilityNo cancel feeOn-time69%

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