HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Louisville

$176+ Cheap flights from Des Moines to Louisville (DSM - SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDF
nov. 29 — dic. 61
sáb. 11/29
sáb. 12/6
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Louisville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated octubre 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$251
(Delta)

One-way from

$176
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$360
Provider with most accurate pricing for Des Moines-Louisville Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Louisville Intl flights.
Search Deals
From Des Moines to Louisville Intl
Search Deals
One-way flight from Des Moines to Louisville Intl
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($38 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Find flight deals from Des Moines to Louisville

Cheapest flights from Des Moines to Louisville
Explore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 30, 2025.

This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/102:59 pmDSM - SDF
1 stop7h 09mDelta
vie. 12/126:35 amSDF - DSM
1 stop4h 46mDelta
Deal found 10/29$274
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/101:17 pmDSM - SDF
2 stops7h 32mAmerican Airlines
vie. 12/127:38 amSDF - DSM
1 stop5h 04mAmerican Airlines
Deal found 10/29$279
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/16:53 pmDSM - SDF
1 stop22h 00mMultiple Airlines
jue. 12/411:55 amSDF - DSM
1 stop11h 26mMultiple Airlines
Deal found 10/28$284
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/64:05 pmDSM - SDF
1 stop4h 43mAmerican Airlines
dom. 12/215:49 pmSDF - DSM
1 stop6h 41mAmerican Airlines
Deal found 10/29$289
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/53:18 pmDSM - SDF
1 stop7h 36mAmerican Airlines
dom. 12/211:50 pmSDF - DSM
1 stop5h 15mAmerican Airlines
Deal found 10/29$312
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/58:00 amDSM - SDF
2 stops50h 00mMultiple Airlines
dom. 12/219:21 pmSDF - DSM
1 stop24h 52mMultiple Airlines
Deal found 10/29$313
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/65:25 amDSM - SDF
2 stops9h 45mSouthwest
dom. 12/215:05 amSDF - DSM
2 stops6h 55mSouthwest
Deal found 10/29$326
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/122:16 pmDSM - SDF
1 stop5h 36mDelta
vie. 12/196:35 amSDF - DSM
1 stop4h 46mDelta
Deal found 10/28$327
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/209:19 amDSM - SDF
1 stop22h 29mMultiple Airlines
dom. 11/238:05 pmSDF - DSM
1 stop26h 04mMultiple Airlines
Deal found 10/29$330
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/205:42 amDSM - SDF
2 stops8h 15mAmerican Airlines
dom. 11/236:24 pmSDF - DSM
1 stop5h 29mAmerican Airlines
Deal found 10/29$352

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.

Fly from

Des Moines

Fly to

Louisville

Route

Depart

Return

Price

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

mar. 3/3

10:55 am-3:49 pm

1 stop3h 54m

Louisville Intl

mié. 3/4

6:36 am-10:22 am

1 stop4h 46m

$251

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

vie. 1/16

11:42 am-6:39 pm

1 stop5h 57m

Louisville Intl

lun. 1/19

6:32 pm-11:23 pm

1 stop5h 51m

$274

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

mié. 12/10

1:17 pm-9:49 pm

2 stops7h 32m

Louisville Intl

vie. 12/12

7:38 am-11:42 am

1 stop5h 04m

$279

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

lun. 12/1

6:53 pm-5:53 pm

1 stop22h 00m

Louisville Intl

jue. 12/4

11:55 am-10:21 pm

1 stop11h 26m

$284

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

sáb. 12/6

4:05 pm-9:48 pm

1 stop4h 43m

Louisville Intl

dom. 12/21

5:49 pm-11:30 pm

1 stop6h 41m

$289

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

vie. 12/5

3:18 pm-11:54 pm

1 stop7h 36m

Louisville Intl

dom. 12/21

1:50 pm-6:05 pm

1 stop5h 15m

$312

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

vie. 12/5

8:00 am-11:00 am

2 stops50h 00m

Louisville Intl

dom. 12/21

9:21 pm-9:13 pm

1 stop24h 52m

$313

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

mar. 3/3

11:26 am-8:03 pm

1 stop7h 37m

Louisville Intl

mié. 3/4

11:16 am-5:48 pm

2 stops7h 32m

$316

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

jue. 11/13

10:50 am-6:16 pm

1 stop30h 26m

$176

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Compare providers for flights from Des Moines to Louisville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Louisville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Louisville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Louisville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Louisville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Louisville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Louisville

What is the cheapest month to book a flight from Des Moines to Louisville?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Louisville (average of $118). Flying from Des Moines to Louisville in December is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated octubre 30, 2025.
Read through reviews of airlines operating flights from Des Moines to Louisville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,998 reviews
Delta
7.9
Good
7,998 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Louisville?

    Delta and American Airlines can get you from Des Moines to Louisville in just under 3h 54m. Your travel time can differ by up to 2h 03m. The distance from Des Moines to Louisville is about 480 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Louisville round-trip?

    United Airlines, at $148, was found to be the cheapest airline from Des Moines to Louisville.Alternate airlines to your destination round-trip include Delta and American Airlines. United Airlines is priced at 61% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Louisville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Louisville.

  • Can I find deals for business class flights from Des Moines to Louisville?

    Yes. Cheapflights offers flight deals from Des Moines to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Louisville?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Louisville (average of $118). Flying from Des Moines to Louisville in December is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Louisville

See prices for flight routes from nearby airports that may be better suited for you.
Cedar Rapids to Nashville flights
Omaha to Nashville flights
Des Moines to Nashville flights
Moline to Nashville flights
Des Moines to Knoxville flights
Cedar Rapids to Knoxville flights
Omaha to Knoxville flights
Omaha to Cincinnati flights
Des Moines to Cincinnati flights
Cedar Rapids to Louisville flights
Omaha to Louisville flights
Cedar Rapids to Lexington flights
Moline to Knoxville flights
Cedar Rapids to Cincinnati flights
Des Moines to Lexington flights
Omaha to Lexington flights
Des Moines to Blountville flights
Moline to Louisville flights
Moline to Lexington flights
Dubuque to Nashville flights
La Crosse to Nashville flights
Omaha to Blountville flights
Moline to Cincinnati flights
Sioux City to Nashville flights
Sioux City to Knoxville flights
La Crosse to Louisville flights
Omaha to Evansville flights
Omaha to Huntington flights
Cedar Rapids to Blountville flights
Sioux City to Louisville flights
La Crosse to Cincinnati flights
Waterloo to Nashville flights
Dubuque to Knoxville flights
Dubuque to Louisville flights
Dubuque to Lexington flights
Dubuque to Cincinnati flights

Top 3 airlines flying from Des Moines to Louisville

Discover the top 3 airlines that operate flights from Des Moines to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$148Average$402FlexibilityNo cancel feeOn-time69%
DeltaCheapest$196Average$308FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$264Average$336FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.