$154+ Cheap flights from Des Moines to Louisville (DSM - SDF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/7. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDF
May 22 — May 291
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to LouisvilleExplore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2026.
Explore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2026.
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:00 am
DSM
- SDF
1 stop6h 35m
United Airlines
Mon 5/257:10 am
SDF
- DSM
1 stop4h 17m
United Airlines
Deal found 4/20![United Airlines logo]()
$273
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:35 am
DSM
- SDF
1 stop3h 30m
Southwest
Fri 6/58:05 pm
SDF
- DSM
1 stop4h 25m
Southwest
Deal found 4/21![Southwest logo]()
$295
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:34 pm
DSM
- SDF
1 stop4h 33m
American Airlines
Fri 9/184:50 pm
SDF
- DSM
1 stop8h 15m
American Airlines
Deal found 4/21![American Airlines logo]()
$307
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2110:56 am
DSM
- SDF
1 stop3h 47m
Delta
Sat 5/2310:39 am
SDF
- DSM
1 stop7h 09m
Delta
Deal found 4/21![Delta logo]()
$310
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/301:48 pm
DSM
- SDF
2 stops7h 39m
American Airlines
Thu 6/47:45 pm
SDF
- DSM
1 stop5h 13m
American Airlines
Deal found 4/21![American Airlines logo]()
$315
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:25 am
DSM
- SDF
1 stop5h 28m
Delta
Fri 7/35:59 pm
SDF
- DSM
1 stop4h 00m
Delta
Deal found 4/18![Delta logo]()
$317
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:00 am
DSM
- SDF
1 stop6h 09m
United Airlines
Wed 5/207:15 am
SDF
- DSM
1 stop4h 22m
United Airlines
Deal found 4/20![United Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/301:48 pm
DSM
- SDF
2 stops7h 39m
American Airlines
Fri 6/58:08 pm
SDF
- DSM
1 stop5h 02m
American Airlines
Deal found 4/21![American Airlines logo]()
$322
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:01 am
DSM
- SDF
1 stop3h 58m
Delta
Sat 5/96:05 am
SDF
- DSM
1 stop5h 11m
Delta
Deal found 4/17![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:35 am
DSM
- SDF
1 stop3h 30m
Southwest
Mon 5/255:25 pm
SDF
- DSM
2 stops6h 40m
Southwest
Deal found 4/20![Southwest logo]()
$343
Best flights from Des Moines to LouisvilleDiscover carefully curated flight deals from Des Moines to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 22, 2026.
Discover carefully curated flight deals from Des Moines to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 22, 2026.
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:25 am
DSM
- SDF
1 stop5h 28m
Delta
Fri 7/35:59 pm
SDF
- DSM
1 stop4h 00m
Delta
Deal found 4/18![Delta logo]()
$317
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:00 am
DSM
- SDF
1 stop6h 09m
United Airlines
Wed 5/207:15 am
SDF
- DSM
1 stop4h 22m
United Airlines
Deal found 4/20![United Airlines logo]()
$321
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:20 am
DSM
- SDF
1 stop3h 45m
Southwest
Mon 6/298:05 pm
SDF
- DSM
1 stop4h 25m
Southwest
Deal found 4/20![Southwest logo]()
$347
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/121:04 pm
DSM
- SDF
1 stop5h 04m
Delta
Sun 5/176:05 am
SDF
- DSM
1 stop5h 11m
Delta
Deal found 4/18![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/44:40 pm
DSM
- SDF
2 stops6h 45m
Southwest
Thu 6/118:05 pm
SDF
- DSM
1 stop4h 25m
Southwest
Deal found 4/20![Southwest logo]()
$372
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:50 pm
DSM
- SDF
1 stop3h 59m
United Airlines
Mon 6/15:46 pm
SDF
- DSM
1 stop4h 54m
United Airlines
Deal found 4/17![United Airlines logo]()
$381
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:15 am
DSM
- SDF
1 stop6h 36m
Delta
Sun 5/176:05 am
SDF
- DSM
1 stop5h 11m
Delta
Deal found 4/18![Delta logo]()
$387
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:55 am
DSM
- SDF
2 stops7h 10m
Southwest
Sat 5/98:40 am
SDF
- DSM
1 stop3h 50m
Southwest
Deal found 4/17![Southwest logo]()
$394
Last-minute flights from Des Moines to LouisvilleDiscover last-minute flight deals from Des Moines to Louisville. Data last updated April 22, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Louisville. Data last updated April 22, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/610:56 am
DSM
- SDF
1 stop6h 19m
Delta
Sat 5/96:05 am
SDF
- DSM
1 stop5h 11m
Delta
Deal found 4/18![Delta logo]()
$375
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:01 am
DSM
- SDF
1 stop3h 58m
Delta
Sat 5/96:05 am
SDF
- DSM
1 stop5h 11m
Delta
Deal found 4/17![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:05 pm
DSM
- SDF
1 stop3h 51m
United Airlines
Thu 5/145:40 am
SDF
- DSM
1 stop5h 57m
United Airlines
Deal found 4/22![United Airlines logo]()
$372
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:00 am
DSM
- SDF
1 stop6h 09m
United Airlines
Wed 5/207:15 am
SDF
- DSM
1 stop4h 22m
United Airlines
Deal found 4/20![United Airlines logo]()
$321
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2110:56 am
DSM
- SDF
1 stop3h 47m
Delta
Sat 5/2310:39 am
SDF
- DSM
1 stop7h 09m
Delta
Deal found 4/21![Delta logo]()
$310
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:16 am
DSM
- SDF
1 stop4h 01m
American Airlines
Sat 5/235:43 pm
SDF
- DSM
2 stops7h 29m
American Airlines
Deal found 4/21![American Airlines logo]()
$357
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:00 am
DSM
- SDF
1 stop6h 35m
United Airlines
Mon 5/257:10 am
SDF
- DSM
1 stop4h 17m
United Airlines
Deal found 4/20![United Airlines logo]()
$273
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:35 am
DSM
- SDF
1 stop3h 30m
Southwest
Mon 5/255:25 pm
SDF
- DSM
2 stops6h 40m
Southwest
Deal found 4/20![Southwest logo]()
$343
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:35 am
DSM
- SDF
1 stop3h 30m
Southwest
Fri 6/58:05 pm
SDF
- DSM
1 stop4h 25m
Southwest
Deal found 4/21![Southwest logo]()
$295
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/301:48 pm
DSM
- SDF
2 stops7h 39m
American Airlines
Thu 6/47:45 pm
SDF
- DSM
1 stop5h 13m
American Airlines
Deal found 4/21![American Airlines logo]()
$315
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/301:48 pm
DSM
- SDF
2 stops7h 39m
American Airlines
Fri 6/58:08 pm
SDF
- DSM
1 stop5h 02m
American Airlines
Deal found 4/21![American Airlines logo]()
$322
One-way flights from Des Moines to LouisvilleSearch for one-way flight options from Des Moines to Louisville. Find affordable one-way fares based on user searches. Data last updated April 22, 2026.
Search for one-way flight options from Des Moines to Louisville. Find affordable one-way fares based on user searches. Data last updated April 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:45 am
DSM
- SDF
1 stop24h 43m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$154
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:31 pm
DSM
- SDF
1 stop4h 28m
Delta
Deal found 4/20![Delta logo]()
$230
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:55 am
DSM
- SDF
2 stops7h 10m
Southwest
Deal found 4/20![Southwest logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/610:30 am
DSM
- SDF
3 stops46h 56m
Allegiant Air
Deal found 4/20![Allegiant Air logo]()
$391
Find flight deals from Des Moines to Louisville
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $273 (United Airlines) |
One-way from | $154 (Kiwi.com) |
Popular in | December |
Cheapest in | January |
Average price | $356 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Tue 6/30
5:25 am-11:53 am
1 stop5h 28m
Louisville Intl
Fri 7/3
5:59 pm-8:59 pm
1 stop4h 00m
$317
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Sat 5/16
8:00 am-3:09 pm
1 stop6h 09m
Louisville Intl
Wed 5/20
7:15 am-10:37 am
1 stop4h 22m
$321
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Tue 5/12
1:04 pm-7:08 pm
1 stop5h 04m
Louisville Intl
Sun 5/17
6:05 am-10:16 am
1 stop5h 11m
$339
Quickest round-trip
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Wed 6/24
5:20 am-10:05 am
1 stop3h 45m
Louisville Intl
Mon 6/29
8:05 pm-11:30 pm
1 stop4h 25m
$347
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Thu 6/4
4:40 pm-12:25 am
2 stops6h 45m
Louisville Intl
Thu 6/11
8:05 pm-11:30 pm
1 stop4h 25m
$372
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Thu 5/28
6:50 pm-11:49 pm
1 stop3h 59m
Louisville Intl
Mon 6/1
5:46 pm-9:40 pm
1 stop4h 54m
$381
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Fri 5/15
6:15 am-1:51 pm
1 stop6h 36m
Louisville Intl
Sun 5/17
6:05 am-10:16 am
1 stop5h 11m
$387
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Wed 5/6
6:55 am-3:05 pm
2 stops7h 10m
Louisville Intl
Sat 5/9
8:40 am-11:30 am
1 stop3h 50m
$394
Cheapest one-way
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Thu 5/7
7:45 am-9:28 am
1 stop24h 43m
$154
Quickest one-way
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Wed 5/6
6:31 pm-11:59 pm
1 stop4h 28m
$230
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Louisville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Louisville in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Louisville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Louisville
Have a flexible travel schedule? Discover the best time to fly to Louisville from Des Moines with our price prediction graph.
DSM-SDF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Louisville
What is the cheapest month to book a flight from Des Moines to Louisville?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Louisville (average of $260). Flying from Des Moines to Louisville in December is currently the most expensive (average of $626). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Louisville?
Reviews of airlines servicing Louisville
Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated April 22, 2026.
Read through reviews of airlines operating flights from Des Moines to Louisville, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Louisville?
Book flights to Louisville if you plan to visit one of these locationsShepherdsville
Elizabethtown
Corydon
Jeffersonville
Bardstown
Browse thousands of different options on Cheapflights for your next trip
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Other flights to Louisville
Explore flights to Louisville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 22, 2026.
Des Moines and Louisville flights
Browse other Des Moines and Louisville flight options. Last updated on April 22, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on April 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Louisville
Discover the top 3 airlines that operate flights from Des Moines to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$129 | Average$298 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$148 | Average$400 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$260 | Average$366 | FlexibilityNo cancel fee | On-time71% |