HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Louisville

$251+ Cheap flights from Des Moines to Louisville (DSM - SDF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/17. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDF
Mar 23 — Mar 301
Mon 3/23
Mon 3/30
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Louisville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Louisville

Cheapest flights from Des Moines to Louisville
Explore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 21, 2026.

This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/174:25 pm
DSM
-
SDF
1 stop5h 44m
Delta
Tue 3/246:15 am
SDF
-
DSM
1 stop4h 54m
Delta
Deal found 2/17$251
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/251:37 pm
DSM
-
SDF
1 stop6h 49m
American Airlines
Sat 3/286:00 am
SDF
-
DSM
1 stop5h 44m
American Airlines
Deal found 2/20$254
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/171:37 pm
DSM
-
SDF
2 stops8h 26m
American Airlines
Tue 3/247:30 am
SDF
-
DSM
1 stop6h 35m
American Airlines
Deal found 2/17$256
This Southwest deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:30 am
DSM
-
SDF
2 stops8h 15m
Southwest
Wed 4/153:45 pm
SDF
-
DSM
2 stops7h 25m
Southwest
Deal found 2/17$261
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:40 am
DSM
-
SDF
1 stop3h 50m
American Airlines
Mon 4/136:00 am
SDF
-
DSM
1 stop5h 26m
American Airlines
Deal found 2/19$276
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/243:00 pm
DSM
-
SDF
1 stop6h 08m
American Airlines
Sun 4/266:00 am
SDF
-
DSM
1 stop5h 26m
American Airlines
Deal found 2/19$277
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:35 am
DSM
-
SDF
1 stop3h 20m
Southwest
Mon 4/134:45 pm
SDF
-
DSM
2 stops7h 20m
Southwest
Deal found 2/19$282
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1810:04 am
DSM
-
SDF
2 stops8h 03m
American Airlines
Wed 3/257:00 am
SDF
-
DSM
2 stops7h 05m
American Airlines
Deal found 2/18$289
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:09 am
DSM
-
SDF
1 stop3h 56m
American Airlines
Sun 4/196:00 am
SDF
-
DSM
1 stop5h 26m
American Airlines
Deal found 2/17$302

Find flight deals from Des Moines to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$251
(Delta)

Popular in

March

Cheapest in

January

Average price

$544
Provider with most accurate pricing for Des Moines-Louisville Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Louisville Intl flights.
Search Deals
From Des Moines to Louisville Intl
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($99 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2026.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.

Fly from

Des Moines

Fly to

Louisville

Route

Depart

Return

Price

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 4/14

3:15 pm-8:35 pm

1 stop4h 20m

Louisville Intl

Wed 4/15

8:55 am-11:25 am

1 stop3h 30m

$251

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 3/17

4:25 pm-11:09 pm

1 stop5h 44m

Louisville Intl

Tue 3/24

6:15 am-10:09 am

1 stop4h 54m

$251

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 3/18

3:28 pm-8:14 pm

1 stop3h 46m

Louisville Intl

Wed 3/25

9:00 am-1:23 pm

1 stop5h 23m

$251

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 3/18

3:40 pm-11:30 pm

2 stops6h 50m

Louisville Intl

Wed 3/25

1:30 pm-8:50 pm

1 stop8h 20m

$256

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 3/25

10:04 am-7:07 pm

2 stops8h 03m

Louisville Intl

Sat 3/28

6:00 am-10:44 am

1 stop5h 44m

$269

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Mon 4/6

6:40 am-11:30 am

1 stop3h 50m

Louisville Intl

Mon 4/13

6:00 am-10:26 am

1 stop5h 26m

$276

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 4/17

6:31 pm-11:59 pm

1 stop4h 28m

Louisville Intl

Sun 4/19

6:04 am-10:16 am

1 stop5h 12m

$277

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 4/24

11:09 am-6:30 pm

1 stop6h 21m

Louisville Intl

Sun 4/26

6:00 am-10:26 am

1 stop5h 26m

$277

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Mon 4/6

5:35 am-9:55 am

1 stop3h 20m

Louisville Intl

Mon 4/13

4:45 pm-11:05 pm

2 stops7h 20m

$282

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 3/18

10:04 am-7:07 pm

2 stops8h 03m

Louisville Intl

Wed 3/25

7:00 am-1:05 pm

2 stops7h 05m

$289

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/19

Showing 1-10 of 13 results
1
2

Compare providers for flights from Des Moines to Louisville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Louisville in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Louisville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Louisville

What is the cheapest month to book a flight from Des Moines to Louisville?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Louisville (average of $118). Flying from Des Moines to Louisville in March is currently the most expensive (average of $301). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated February 21, 2026.
Read through reviews of airlines operating flights from Des Moines to Louisville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,228 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,228 reviews
Delta
7.9
Good
8,228 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,335 reviews
Delta
7.9
Good
8,228 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,334 reviews
Delta
7.9
Good
8,228 reviews

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Louisville?

    Southwest, Delta, and United Airlines can get you from Des Moines to Louisville in just under 3h 46m. Your travel time can differ by up to 1h 58m. The distance from Des Moines to Louisville is about 480 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Louisville round-trip?

    Delta, at $129, was found to be the cheapest airline from Des Moines to Louisville.Alternate airlines to your destination round-trip include United Airlines and American Airlines. Delta is priced at 70% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Louisville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Louisville.

  • Can I find deals for business class flights from Des Moines to Louisville?

    Yes. Cheapflights offers flight deals from Des Moines to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Louisville?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Louisville (average of $118). Flying from Des Moines to Louisville in March is currently the most expensive (average of $301). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Des Moines to Louisville

Discover the top 3 airlines that operate flights from Des Moines to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$129Average$298FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$148Average$400FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$260Average$366FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.