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$184+ Cheap flights from Des Moines to Louisville (DSM - SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDF
Dec 17 — Dec 241
Wed 12/17
Wed 12/24
1 adult, Economy
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Cheap flight deals from Des Moines to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 17, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$251
(Delta)

One-way from

$184
(Delta)

Popular in

November

Cheapest in

October

Average price

$575
Provider with most accurate pricing for Des Moines-Louisville Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Louisville Intl flights.
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From Des Moines to Louisville Intl
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One-way flight from Des Moines to Louisville Intl
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Highest demand for flights based on searches. 6% potential increase in price ($28 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($18 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Des Moines to Louisville

Cheapest flights from Des Moines to Louisville
Explore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 17, 2025.

This Delta deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/211:23 amDSM - SDF
1 stop6h 49mDelta
Sat 12/66:11 pmSDF - DSM
1 stop5h 23mDelta
Deal found 11/16$251
This American Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/21:06 pmDSM - SDF
2 stops7h 33mAmerican Airlines
Sat 12/610:47 amSDF - DSM
1 stop7h 08mAmerican Airlines
Deal found 11/16$256
This American Airlines deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:07 amDSM - SDF
1 stop7h 09mAmerican Airlines
Tue 1/61:32 pmSDF - DSM
1 stop3h 52mAmerican Airlines
Deal found 11/14$280
This Delta deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/306:50 amDSM - SDF
1 stop4h 07mDelta
Thu 12/46:16 pmSDF - DSM
1 stop5h 18mDelta
Deal found 11/15$407
This Delta deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2111:28 amDSM - SDF
1 stop4h 48mDelta
Mon 11/246:00 amSDF - DSM
1 stop5h 42mDelta
Deal found 11/16$424
This American Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/211:06 pmDSM - SDF
2 stops7h 41mAmerican Airlines
Mon 11/249:22 amSDF - DSM
1 stop6h 09mAmerican Airlines
Deal found 11/16$429
This Mytrip deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/303:45 pmDSM - SDF
1 stop15h 39mMultiple Airlines
Thu 12/411:55 amSDF - DSM
2 stops21h 46mMultiple Airlines
Deal found 11/15$447
This American Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/211:53 pmDSM - SDF
1 stop6h 36mAmerican Airlines
Sat 11/298:10 amSDF - DSM
1 stop6h 19mAmerican Airlines
Deal found 11/16$517
This Kiwi.com deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/282:53 pmDSM - SDF
1 stop16h 20mAllegiant Air
Sun 11/303:24 pmSDF - DSM
1 stop23h 14mAllegiant Air
Deal found 11/15$518
This United Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/201:35 pmDSM - SDF
1 stop7h 55mUnited Airlines
Sat 11/229:00 amSDF - DSM
1 stop6h 19mUnited Airlines
Deal found 11/16$537

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 17, 2025.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.

Fly from

Des Moines

Fly to

Louisville

Route

Depart

Return

Price

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 3/3

4:21 pm-11:07 pm

1 stop5h 46m

Louisville Intl

Wed 3/4

6:23 am-10:17 am

1 stop4h 54m

$251

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 12/2

11:23 am-7:12 pm

1 stop6h 49m

Louisville Intl

Sat 12/6

6:11 pm-10:34 pm

1 stop5h 23m

$251

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 12/2

1:06 pm-9:39 pm

2 stops7h 33m

Louisville Intl

Sat 12/6

10:47 am-4:55 pm

1 stop7h 08m

$256

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 3/3

6:33 am-6:00 pm

2 stops10h 27m

Louisville Intl

Wed 3/4

6:38 pm-11:42 pm

1 stop6h 04m

$316

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sun 11/30

6:50 am-11:57 am

1 stop4h 07m

Louisville Intl

Thu 12/4

6:16 pm-10:34 pm

1 stop5h 18m

$407

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sat 12/27

6:15 am-1:12 pm

1 stop5h 57m

$184

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sun 12/28

6:30 am-1:30 pm

1 stop6h 00m

$194

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sat 12/27

5:40 am-5:55 pm

2 stops11h 15m

$293

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sun 12/28

3:44 pm-11:59 pm

2 stops31h 15m

$414

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sat 12/27

8:29 pm-11:59 pm

3 stops50h 30m

$418

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/15

Compare providers for flights from Des Moines to Louisville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Louisville in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Louisville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Louisville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Louisville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Louisville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Louisville

What is the cheapest month to book a flight from Des Moines to Louisville?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Louisville (average of $118). Flying from Des Moines to Louisville in November is currently the most expensive (average of $291). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated November 17, 2025.
Read through reviews of airlines operating flights from Des Moines to Louisville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Crew

8.5

Food

7.3

Boarding

8.1

Entertainment

7.9

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Food

7.3

Boarding

8.1

Entertainment

7.9

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,013 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Food

7.3

Boarding

8.1

Entertainment

7.9

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Food

7.3

Boarding

8.1

Entertainment

7.9

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Louisville?

    Delta and American Airlines can get you from Des Moines to Louisville in just under 5h 46m. Your travel time can differ by up to 1h 47m. The distance from Des Moines to Louisville is about 480 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Louisville round-trip?

    United Airlines, at $148, was found to be the cheapest airline from Des Moines to Louisville.Alternate airlines to your destination round-trip include Delta and American Airlines. United Airlines is priced at 60% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Louisville one-way?

    $184 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and Southwest, with prices starting from $194 and $293, respectively.

  • Can I find deals for flights from Des Moines to Louisville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Louisville.

  • Can I find deals for business class flights from Des Moines to Louisville?

    Yes. Cheapflights offers flight deals from Des Moines to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Louisville?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Louisville (average of $118). Flying from Des Moines to Louisville in November is currently the most expensive (average of $291). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

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Top 3 airlines flying from Des Moines to Louisville

Discover the top 3 airlines that operate flights from Des Moines to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$148Average$402FlexibilityNo cancel feeOn-time69%
DeltaCheapest$196Average$308FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$264Average$336FlexibilityNo cancel feeOn-time71%

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