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$126+ Cheap flights from Des Moines to Louisville (DSM - SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDF
feb. 20 — feb. 271
vie. 2/20
vie. 2/27
1 adult, Economy
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Cheap flight deals from Des Moines to Louisville

Cheapest flights from Des Moines to Louisville
Explore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 21, 2026.

This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/105:16 pm
DSM
-
SDF
1 stop5h 34m
Delta
sáb. 2/1410:46 am
SDF
-
DSM
1 stop7h 11m
Delta
Deal found 1/20$251
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/107:10 am
DSM
-
SDF
2 stops10h 20m
American Airlines
mié. 2/116:32 pm
SDF
-
DSM
1 stop5h 51m
American Airlines
Deal found 1/20$256
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/1011:35 am
DSM
-
SDF
2 stops9h 30m
American Airlines
sáb. 2/145:00 am
SDF
-
DSM
2 stops9h 05m
American Airlines
Deal found 1/20$262
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/1112:25 pm
DSM
-
SDF
1 stop4h 48m
Delta
jue. 2/1210:46 am
SDF
-
DSM
1 stop7h 11m
Delta
Deal found 1/21$270
This Southwest deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/183:20 pm
DSM
-
SDF
2 stops5h 50m
Southwest
mié. 2/2512:50 pm
SDF
-
DSM
2 stops9h 20m
Southwest
Deal found 1/21$281
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/183:26 pm
DSM
-
SDF
1 stop7h 47m
American Airlines
mié. 2/257:35 am
SDF
-
DSM
2 stops6h 30m
American Airlines
Deal found 1/21$284
This Southwest deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/113:20 pm
DSM
-
SDF
2 stops5h 50m
Southwest
jue. 2/125:30 am
SDF
-
DSM
2 stops19h 05m
Southwest
Deal found 1/21$302
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 2/141:29 pm
DSM
-
SDF
1 stop8h 08m
United Airlines
mié. 2/183:30 pm
SDF
-
DSM
1 stop7h 50m
United Airlines
Deal found 1/19$311
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 6/233:15 pm
DSM
-
SDF
1 stop3h 59m
United Airlines
dom. 6/286:00 pm
SDF
-
DSM
1 stop5h 52m
United Airlines
Deal found 1/21$317
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/213:15 pm
DSM
-
SDF
1 stop5h 54m
United Airlines
mar. 5/2611:00 am
SDF
-
DSM
1 stop4h 11m
United Airlines
Deal found 1/19$326
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/36:34 pm
DSM
-
SDF
1 stop4h 33m
American Airlines
lun. 10/56:36 pm
SDF
-
DSM
1 stop5h 00m
American Airlines
Deal found 1/20$327
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/105:16 pm
DSM
-
SDF
1 stop5h 34m
Delta
mié. 2/116:23 am
SDF
-
DSM
1 stop5h 28m
Delta
Deal found 1/21$329

Find flight deals from Des Moines to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated enero 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$251
(Delta)

One-way from

$126
(United Airlines)

Popular in

December

Cheapest in

March

Average price

$276
Provider with most accurate pricing for Des Moines-Louisville Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Louisville Intl flights.
Search Deals
From Des Moines to Louisville Intl
Search Deals
One-way flight from Des Moines to Louisville Intl
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($86 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 21, 2026.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.

Fly from

Des Moines

Fly to

Louisville

Route

Depart

Return

Price

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

mar. 2/10

3:35 pm-10:30 pm

1 stop5h 55m

Louisville Intl

mié. 2/11

8:29 am-2:33 pm

1 stop7h 04m

$251

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

mar. 2/10

5:16 pm-11:50 pm

1 stop5h 34m

Louisville Intl

sáb. 2/14

10:46 am-4:57 pm

1 stop7h 11m

$251

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

mar. 2/10

3:35 pm-10:30 pm

1 stop5h 55m

Louisville Intl

sáb. 2/14

9:00 am-2:27 pm

1 stop6h 27m

$251

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

mar. 2/10

7:10 am-6:30 pm

2 stops10h 20m

Louisville Intl

mié. 2/11

6:32 pm-11:23 pm

1 stop5h 51m

$256

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

mar. 2/10

11:35 am-10:05 pm

2 stops9h 30m

Louisville Intl

sáb. 2/14

5:00 am-1:05 pm

2 stops9h 05m

$262

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

mié. 2/11

12:25 pm-6:13 pm

1 stop4h 48m

Louisville Intl

jue. 2/12

10:46 am-4:57 pm

1 stop7h 11m

$270

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

mié. 2/18

3:20 pm-10:10 pm

2 stops5h 50m

Louisville Intl

mié. 2/25

12:50 pm-9:10 pm

2 stops9h 20m

$281

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

mié. 2/11

3:20 pm-10:10 pm

2 stops5h 50m

Louisville Intl

jue. 2/12

5:30 am-11:35 pm

2 stops19h 05m

$302

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

sáb. 2/14

1:29 pm-10:37 pm

1 stop8h 08m

Louisville Intl

mié. 2/18

3:30 pm-10:20 pm

1 stop7h 50m

$311

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

mar. 6/23

3:15 pm-8:14 pm

1 stop3h 59m

Louisville Intl

dom. 6/28

6:00 pm-10:52 pm

1 stop5h 52m

$317

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Showing 1-10 of 16 results
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Compare providers for flights from Des Moines to Louisville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Louisville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Louisville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Louisville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Louisville

What is the cheapest month to book a flight from Des Moines to Louisville?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Louisville (average of $118). Flying from Des Moines to Louisville in December is currently the most expensive (average of $301). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated enero 21, 2026.
Read through reviews of airlines operating flights from Des Moines to Louisville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,089 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,089 reviews
Delta
7.9
Good
8,089 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,191 reviews
Delta
7.9
Good
8,089 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,174 reviews
Delta
7.9
Good
8,089 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Louisville?

    United Airlines, Delta, and American Airlines can get you from Des Moines to Louisville in just under 5h 34m. Your travel time can differ by up to 4h 46m. The distance from Des Moines to Louisville is about 480 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Louisville round-trip?

    Delta, at $129, was found to be the cheapest airline from Des Moines to Louisville.Alternate airlines to your destination round-trip include United Airlines and American Airlines. Delta is priced at 66% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Louisville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Louisville.

  • Can I find deals for business class flights from Des Moines to Louisville?

    Yes. Cheapflights offers flight deals from Des Moines to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Louisville?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Louisville (average of $118). Flying from Des Moines to Louisville in December is currently the most expensive (average of $301). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

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Alternative routes for Des Moines to Louisville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Des Moines to Louisville

Discover the top 3 airlines that operate flights from Des Moines to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$129Average$298FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$148Average$400FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$260Average$329FlexibilityNo cancel feeOn-time71%

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