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$156+ Cheap flights from Des Moines to Louisville (DSM - SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDF
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Des Moines to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$251
(Delta)

One-way from

$156
(United Airlines)

Popular in

December

Cheapest in

August

Average price

$353
From Des Moines to Louisville Intl
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One-way flight from Des Moines to Louisville Intl
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Highest demand for flights based on searches. 10% potential increase in price ($47 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Louisville

Cheapest flights from Des Moines to Louisville
Explore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/216:39 pmDSM - SDF
1 stop4h 22mDelta
Sun 10/266:00 amSDF - DSM
1 stop5h 05mDelta
Deal found 9/15$282
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/222:37 pmDSM - SDF
2 stops31h 10mMultiple Airlines
Sun 10/268:45 pmSDF - DSM
1 stop12h 49mMultiple Airlines
Deal found 9/15$303
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1610:41 amDSM - SDF
1 stop21h 20mAllegiant Air
Sun 10/268:45 pmSDF - DSM
1 stop12h 49mAllegiant Air
Deal found 9/15$304
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/246:39 pmDSM - SDF
1 stop4h 22mDelta
Sun 10/266:00 amSDF - DSM
1 stop5h 05mDelta
Deal found 9/15$309
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2211:31 amDSM - SDF
1 stop6h 02mUnited Airlines
Sun 10/269:00 amSDF - DSM
1 stop4h 14mUnited Airlines
Deal found 9/15$314
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1610:41 amDSM - SDF
1 stop23h 11mMultiple Airlines
Sun 10/266:58 pmSDF - DSM
2 stops20h 52mMultiple Airlines
Deal found 9/15$357
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/3011:17 amDSM - SDF
1 stop4h 48mDelta
Sat 10/46:00 amSDF - DSM
1 stop5h 40mDelta
Deal found 9/15$387
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:00 amDSM - SDF
1 stop7h 36mAmerican Airlines
Sat 10/41:06 pmSDF - DSM
2 stops8h 15mAmerican Airlines
Deal found 9/15$392
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/36:35 amDSM - SDF
2 stops9h 00mSouthwest
Sun 10/51:45 pmSDF - DSM
2 stops11h 00mSouthwest
Deal found 9/15$435
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2110:15 amDSM - SDF
2 stops11h 30mSouthwest
Sun 10/261:45 pmSDF - DSM
2 stops11h 00mSouthwest
Deal found 9/15$465
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2510:20 amDSM - SDF
1 stop6h 33mDelta
Sat 9/277:10 amSDF - DSM
1 stop4h 30mDelta
Deal found 9/15$467

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.

Fly from

Des Moines

Fly to

Louisville

Route

Depart

Return

Price

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 3/3

4:00 pm-10:55 pm

1 stop5h 55m

Louisville Intl

Wed 3/4

6:36 am-10:22 am

1 stop4h 46m

$251

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 10/21

6:39 pm-12:01 am

1 stop4h 22m

Louisville Intl

Sun 10/26

6:00 am-10:05 am

1 stop5h 05m

$282

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 10/22

2:37 pm-10:47 pm

2 stops31h 10m

Louisville Intl

Sun 10/26

8:45 pm-8:34 am

1 stop12h 49m

$303

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Thu 10/16

10:41 am-9:01 am

1 stop21h 20m

Louisville Intl

Sun 10/26

8:45 pm-8:34 am

1 stop12h 49m

$304

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 10/24

6:39 pm-12:01 am

1 stop4h 22m

Louisville Intl

Sun 10/26

6:00 am-10:05 am

1 stop5h 05m

$309

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 10/22

11:31 am-6:33 pm

1 stop6h 02m

Louisville Intl

Sun 10/26

9:00 am-12:14 pm

1 stop4h 14m

$314

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 3/3

4:27 pm-12:39 am

2 stops7h 12m

Louisville Intl

Wed 3/4

6:57 am-12:30 pm

1 stop6h 33m

$316

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Thu 10/16

10:41 am-10:52 am

1 stop23h 11m

Louisville Intl

Sun 10/26

6:58 pm-2:50 pm

2 stops20h 52m

$357

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sat 11/1

9:01 am-10:29 pm

2 stops12h 28m

$333

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Best time to book a flight from Des Moines to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Louisville

What is the cheapest month to book a flight from Des Moines to Louisville?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Louisville (average of $299). Flying from Des Moines to Louisville in April is currently the most expensive (average of $369). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated September 17, 2025.
Read through reviews of airlines operating flights from Des Moines to Louisville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Louisville?

    Delta and Allegiant Air can get you from Des Moines to Louisville in just under 5h 55m. Your travel time can differ by up to 15h 25m. The distance from Des Moines to Louisville is about 480 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Louisville round-trip?

    Delta, at $196, was found to be the cheapest airline from Des Moines to Louisville.Alternate airlines to your destination round-trip include American Airlines and United Airlines. Delta is priced at 49% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Louisville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Louisville.

  • Can I find deals for business class flights from Des Moines to Louisville?

    Yes. Cheapflights offers flight deals from Des Moines to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Louisville?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Louisville (average of $299). Flying from Des Moines to Louisville in April is currently the most expensive (average of $369). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

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Top 3 airlines flying from Des Moines to Louisville

Discover the top 3 airlines that operate flights from Des Moines to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$196Average$308FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$264Average$426FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$306Average$468FlexibilityNo cancel feeOn-time69%

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