$138+ Cheap flights from Des Moines to Louisville (DSM - SDF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDF
Jun 17 — Jun 241
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to LouisvilleExplore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 18, 2026.
Explore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 18, 2026.
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:51 pm
DSM
- SDF
1 stop3h 57m
American Airlines
Tue 7/78:05 pm
SDF
- DSM
1 stop5h 04m
American Airlines
Deal found 5/15![American Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:35 am
DSM
- SDF
1 stop5h 18m
Delta
Wed 6/2412:38 pm
SDF
- DSM
1 stop5h 16m
Delta
Deal found 5/14![Delta logo]()
$307
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:15 am
DSM
- SDF
2 stops12h 20m
Southwest
Tue 9/18:45 am
SDF
- DSM
1 stop4h 05m
Southwest
Deal found 5/15![Southwest logo]()
$312
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:20 am
DSM
- SDF
1 stop3h 45m
Southwest
Tue 7/77:25 am
SDF
- DSM
2 stops16h 20m
Southwest
Deal found 5/15![Southwest logo]()
$323
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:35 am
DSM
- SDF
1 stop5h 18m
Delta
Fri 7/35:59 pm
SDF
- DSM
1 stop4h 09m
Delta
Deal found 5/18![Delta logo]()
$327
This American Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:51 pm
DSM
- SDF
2 stops7h 36m
American Airlines
Fri 7/37:37 am
SDF
- DSM
1 stop5h 57m
American Airlines
Deal found 5/17![American Airlines logo]()
$332
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/253:35 pm
DSM
- SDF
1 stop3h 25m
Southwest
Wed 7/297:45 pm
SDF
- DSM
1 stop4h 00m
Southwest
Deal found 5/15![Southwest logo]()
$337
This Southwest deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/173:45 pm
DSM
- SDF
1 stop3h 40m
Southwest
Wed 6/247:25 am
SDF
- DSM
2 stops16h 20m
Southwest
Deal found 5/14![Southwest logo]()
$343
This Southwest deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:10 am
DSM
- SDF
1 stop3h 55m
Southwest
Tue 6/167:45 pm
SDF
- DSM
1 stop4h 00m
Southwest
Deal found 5/18![Southwest logo]()
$347
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:10 am
DSM
- SDF
2 stops5h 50m
Southwest
Tue 6/305:35 am
SDF
- DSM
2 stops18h 10m
Southwest
Deal found 5/15![Southwest logo]()
$349
Best flights from Des Moines to LouisvilleDiscover carefully curated flight deals from Des Moines to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 18, 2026.
Discover carefully curated flight deals from Des Moines to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 18, 2026.
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:10 am
DSM
- SDF
1 stop4h 05m
Southwest
Tue 9/16:45 pm
SDF
- DSM
1 stop4h 10m
Southwest
Deal found 5/15![Southwest logo]()
$307
This Delta deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:08 am
DSM
- SDF
1 stop6h 31m
Delta
Tue 6/305:26 pm
SDF
- DSM
1 stop4h 15m
Delta
Deal found 5/15![Delta logo]()
$327
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/235:30 am
DSM
- SDF
1 stop6h 11m
American Airlines
Sun 6/287:18 pm
SDF
- DSM
1 stop6h 17m
American Airlines
Deal found 5/13![American Airlines logo]()
$327
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:35 am
DSM
- SDF
1 stop5h 18m
Delta
Fri 7/35:59 pm
SDF
- DSM
1 stop4h 09m
Delta
Deal found 5/18![Delta logo]()
$327
This American Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:51 pm
DSM
- SDF
2 stops7h 36m
American Airlines
Fri 7/37:37 am
SDF
- DSM
1 stop5h 57m
American Airlines
Deal found 5/17![American Airlines logo]()
$332
This Southwest deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/173:45 pm
DSM
- SDF
1 stop3h 40m
Southwest
Wed 6/247:25 am
SDF
- DSM
2 stops16h 20m
Southwest
Deal found 5/14![Southwest logo]()
$343
Last-minute flights from Des Moines to LouisvilleDiscover last-minute flight deals from Des Moines to Louisville. Data last updated May 18, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Louisville. Data last updated May 18, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:10 am
DSM
- SDF
1 stop3h 55m
Southwest
Tue 6/167:45 pm
SDF
- DSM
1 stop4h 00m
Southwest
Deal found 5/18![Southwest logo]()
$347
This Southwest deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/133:35 pm
DSM
- SDF
1 stop3h 25m
Southwest
Sat 6/207:15 pm
SDF
- DSM
1 stop4h 35m
Southwest
Deal found 5/16![Southwest logo]()
$367
This Delta deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:35 am
DSM
- SDF
1 stop5h 18m
Delta
Wed 6/2412:38 pm
SDF
- DSM
1 stop5h 16m
Delta
Deal found 5/14![Delta logo]()
$307
This Southwest deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/173:45 pm
DSM
- SDF
1 stop3h 40m
Southwest
Wed 6/247:25 am
SDF
- DSM
2 stops16h 20m
Southwest
Deal found 5/14![Southwest logo]()
$343
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:10 am
DSM
- SDF
2 stops5h 50m
Southwest
Tue 6/305:35 am
SDF
- DSM
2 stops18h 10m
Southwest
Deal found 5/15![Southwest logo]()
$349
This American Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/251:37 pm
DSM
- SDF
1 stop4h 46m
American Airlines
Sun 6/287:18 pm
SDF
- DSM
1 stop6h 17m
American Airlines
Deal found 5/16![American Airlines logo]()
$357
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:51 pm
DSM
- SDF
1 stop3h 57m
American Airlines
Tue 7/78:05 pm
SDF
- DSM
1 stop5h 04m
American Airlines
Deal found 5/15![American Airlines logo]()
$304
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:20 am
DSM
- SDF
1 stop3h 45m
Southwest
Tue 7/77:25 am
SDF
- DSM
2 stops16h 20m
Southwest
Deal found 5/15![Southwest logo]()
$323
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:35 am
DSM
- SDF
1 stop5h 18m
Delta
Fri 7/35:59 pm
SDF
- DSM
1 stop4h 09m
Delta
Deal found 5/18![Delta logo]()
$327
This American Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:51 pm
DSM
- SDF
2 stops7h 36m
American Airlines
Fri 7/37:37 am
SDF
- DSM
1 stop5h 57m
American Airlines
Deal found 5/17![American Airlines logo]()
$332
One-way flights from Des Moines to LouisvilleSearch for one-way flight options from Des Moines to Louisville. Find affordable one-way fares based on user searches. Data last updated May 18, 2026.
Search for one-way flight options from Des Moines to Louisville. Find affordable one-way fares based on user searches. Data last updated May 18, 2026.
This Trip.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:00 am
DSM
- SDF
1 stop11h 28m
Allegiant Air
Deal found 5/16![Allegiant Air logo]()
$138
This Delta deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:27 am
DSM
- SDF
1 stop5h 41m
Delta
Deal found 5/16![Delta logo]()
$174
This American Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:48 pm
DSM
- SDF
2 stops7h 39m
American Airlines
Deal found 5/16![American Airlines logo]()
$179
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/253:35 pm
DSM
- SDF
1 stop3h 25m
Southwest
Deal found 5/15![Southwest logo]()
$184
This Delta deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:41 pm
DSM
- SDF
1 stop4h 44m
Delta
Deal found 5/13![Delta logo]()
$194
This Southwest deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:40 pm
DSM
- SDF
2 stops6h 45m
Southwest
Deal found 5/13![Southwest logo]()
$199
This Delta deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:41 pm
DSM
- SDF
1 stop4h 44m
Delta
Deal found 5/16![Delta logo]()
$230
This Southwest deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:30 am
DSM
- SDF
2 stops8h 15m
Southwest
Deal found 5/16![Southwest logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:40 am
DSM
- SDF
3 stops49h 15m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$278
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/258:45 am
DSM
- SDF
2 stops9h 46m
American Airlines
Deal found 5/15![American Airlines logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3110:01 pm
DSM
- SDF
3 stops57h 11m
Multiple Airlines
Deal found 5/14![Multiple Airlines logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/512:56 pm
DSM
- SDF
3 stops54h 48m
Allegiant Air
Deal found 5/13![Allegiant Air logo]()
$301
Find flight deals from Des Moines to Louisville
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $304 (American Airlines) |
One-way from | $138 (Trip.com) |
Popular in | December |
Cheapest in | January |
Average price | $391 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 18, 2026.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Tue 8/25
6:10 am-11:15 am
1 stop4h 05m
Louisville Intl
Tue 9/1
6:45 pm-9:55 pm
1 stop4h 10m
$307
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Thu 6/18
6:08 am-1:39 pm
1 stop6h 31m
Louisville Intl
Tue 6/30
5:26 pm-8:41 pm
1 stop4h 15m
$327
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Tue 6/23
5:30 am-12:41 pm
1 stop6h 11m
Louisville Intl
Sun 6/28
7:18 pm-12:35 am
1 stop6h 17m
$327
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Tue 6/30
5:35 am-11:53 am
1 stop5h 18m
Louisville Intl
Fri 7/3
5:59 pm-9:08 pm
1 stop4h 09m
$327
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Tue 6/30
1:51 pm-10:27 pm
2 stops7h 36m
Louisville Intl
Fri 7/3
7:37 am-12:34 pm
1 stop5h 57m
$332
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Wed 6/17
3:45 pm-8:25 pm
1 stop3h 40m
Louisville Intl
Wed 6/24
7:25 am-10:45 pm
2 stops16h 20m
$343
Cheapest one-way
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Mon 5/25
7:00 am-7:28 pm
1 stop11h 28m
$138
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Fri 7/31
7:05 am-12:00 pm
1 stop3h 55m
$174
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Wed 5/27
7:01 am-11:59 am
1 stop3h 58m
$174
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Thu 5/28
5:25 am-4:50 pm
2 stops10h 25m
$179
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Louisville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Louisville in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Louisville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Louisville
Have a flexible travel schedule? Discover the best time to fly to Louisville from Des Moines with our price prediction graph.
DSM-SDF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Louisville
What is the cheapest month to book a flight from Des Moines to Louisville?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Louisville (average of $260). Flying from Des Moines to Louisville in December is currently the most expensive (average of $626). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Louisville?
Reviews of airlines servicing Louisville
Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated May 18, 2026.
Read through reviews of airlines operating flights from Des Moines to Louisville, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Boarding
8.1
Comfort
7.8
Overall
7.9
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Boarding
8.1
Comfort
7.8
Overall
7.9
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Boarding
8.1
Comfort
7.8
Overall
7.9
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Boarding
8.1
Comfort
7.8
Overall
7.9
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Louisville?
Book flights to Louisville if you plan to visit one of these locationsShepherdsville
Elizabethtown
Corydon
Jeffersonville
Bardstown
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Other flights to Louisville
Explore flights to Louisville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 18, 2026.
Des Moines and Louisville flights
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Other flights from Des Moines
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Top 3 airlines flying from Des Moines to Louisville
Discover the top 3 airlines that operate flights from Des Moines to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$129 | Average$298 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$148 | Average$386 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$260 | Average$402 | FlexibilityNo cancel fee | On-time71% |