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Knoxville

$140+ Cheap flights from St. Louis to Knoxville (STL - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/6. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from St. Louis to Knoxville

Cheapest flights from St. Louis to Knoxville
Explore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amSTL - TYS
1 stop5h 14mDelta
Mon 12/296:59 pmTYS - STL
1 stop3h 44mDelta
Deal found 12/10$369
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1810:42 amSTL - TYS
2 stops10h 14mMultiple Airlines
Mon 12/229:15 pmTYS - STL
1 stop14h 41mMultiple Airlines
Deal found 12/10$384
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:43 pmSTL - TYS
2 stops24h 48mMultiple Airlines
Sun 1/46:30 amTYS - STL
1 stop28h 32mMultiple Airlines
Deal found 12/11$390
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/254:27 pmSTL - TYS
1 stop16h 48mMultiple Airlines
Mon 12/296:00 amTYS - STL
2 stops28h 40mMultiple Airlines
Deal found 12/10$423
This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:00 amSTL - TYS
1 stop6h 30mDelta
Thu 1/18:35 amTYS - STL
1 stop4h 49mDelta
Deal found 12/10$448
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/285:00 amSTL - TYS
1 stop6h 52mAmerican Airlines
Thu 1/15:40 pmTYS - STL
1 stop7h 15mAmerican Airlines
Deal found 12/10$453
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/201:59 pmSTL - TYS
1 stop5h 44mAmerican Airlines
Mon 1/55:08 pmTYS - STL
1 stop7h 36mAmerican Airlines
Deal found 12/10$457
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2910:40 amSTL - TYS
1 stop10h 08mMultiple Airlines
Thu 1/112:50 pmTYS - STL
1 stop10h 43mMultiple Airlines
Deal found 12/10$462
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/159:54 amSTL - TYS
1 stop6h 26mMultiple Airlines
Thu 12/186:30 amTYS - STL
2 stops26h 42mMultiple Airlines
Deal found 12/10$499

Find flight deals from St. Louis to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$265
(American Airlines)

One-way from

$140
(Delta)

Popular in

January

Cheapest in

July

Average price

$337
Provider with most accurate pricing for Lambert-St Louis-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Knoxville McGhee Tyson flights.
Search Deals
From Lambert-St Louis to Knoxville McGhee Tyson
Search Deals
One-way flight from Lambert-St Louis to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($22 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

St. Louis

Fly to

Knoxville

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 1/14

6:52 am-11:47 am

1 stop3h 55m

Knoxville McGhee Tyson

Fri 1/16

12:19 pm-7:29 pm

1 stop8h 10m

$265

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 2/1

6:30 am-1:24 pm

1 stop5h 54m

Knoxville McGhee Tyson

Sat 2/7

6:45 am-12:29 pm

1 stop6h 44m

$265

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 1/24

6:00 am-11:08 am

1 stop4h 08m

Knoxville McGhee Tyson

Sun 1/25

5:40 am-8:53 am

1 stop4h 13m

$265

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 1/15

3:37 pm-10:47 pm

1 stop6h 10m

Knoxville McGhee Tyson

Sun 1/18

6:51 pm-10:59 pm

1 stop5h 08m

$278

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 3/31

10:02 am-4:06 pm

1 stop5h 04m

Knoxville McGhee Tyson

Tue 4/7

5:30 am-8:52 am

1 stop4h 22m

$279

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 3/31

5:00 pm-11:51 pm

1 stop5h 51m

Knoxville McGhee Tyson

Wed 4/8

5:30 am-8:52 am

1 stop4h 22m

$279

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 3/27

6:59 pm-11:51 pm

1 stop3h 52m

Knoxville McGhee Tyson

Thu 4/2

5:01 pm-9:10 pm

1 stop5h 09m

$279

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 3/30

10:02 am-4:06 pm

1 stop5h 04m

Knoxville McGhee Tyson

Tue 4/7

5:30 am-8:52 am

1 stop4h 22m

$279

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 4/1

6:00 am-11:18 am

1 stop4h 18m

Knoxville McGhee Tyson

Fri 4/3

5:01 pm-9:10 pm

1 stop5h 09m

$279

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 4/1

6:00 am-11:18 am

1 stop4h 18m

Knoxville McGhee Tyson

Sat 4/4

5:30 am-8:52 am

1 stop4h 22m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/8

Showing 1-10 of 20 results
1
2

Compare providers for flights from St. Louis to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Knoxville in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on St. Louis-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from St. Louis-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Knoxville

What is the cheapest month to book a flight from St. Louis to Knoxville?

Currently, August is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $149). Flying from St. Louis to Knoxville in November is currently the most expensive (average of $250). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to TYS?

Find hourly flight availability from St. Louis to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

When flying from St. Louis to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 27% versus a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 12, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from St. Louis to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Overall

7.9

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Overall

7.9

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,095 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Overall

7.9

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Overall

7.9

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Knoxville?

    Departing from St. Louis to Knoxville will take you 3h 55m. St. Louis and Knoxville are separated by a distance of 405 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from St. Louis to Knoxville round-trip?

    According to our current data, American Airlines ($213), United Airlines ($213), and Delta ($222) offers the cheapest pricing from St. Louis to Knoxville. American Airlines is priced at 34% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from St. Louis to Knoxville that include hotel bookings?

    Yes. In addition to deals on St. Louis to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Knoxville.

  • Can I find deals for business class flights from St. Louis to Knoxville?

    Yes. Cheapflights offers flight deals from St. Louis to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $149). Flying from St. Louis to Knoxville in November is currently the most expensive (average of $250). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from St. Louis to Knoxville

Discover the top 3 airlines that operate flights from St. Louis to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$213Average$315FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$213Average$298FlexibilityNo cancel feeOn-time71%
DeltaCheapest$222Average$298FlexibilityNo cancel feeOn-timeN/A

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