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$126+ Cheap flights from St. Louis to Knoxville (STL - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Aug 2 — Aug 91
Sat 8/2
Sat 8/9
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Knoxville McGhee Tyson are usually found in July or November, booked 16 days in advance, depart on a Thursday or Wednesday and return on a Wednesday

Cheap flight deals from St. Louis to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 28, 2025.

Round-trip from

$199
(Delta)

One-way from

$126
(Delta)

Popular in

December

Cheapest in

July

Average price

$255
From Lambert-St Louis to Knoxville McGhee Tyson
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One-way flight from Lambert-St Louis to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 11% potential increase in price ($45 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from St. Louis to Knoxville

Cheapest flights from St. Louis to Knoxville
Explore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2025.

This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/306:00 amSTL - TYS
1 stop6h 08mDelta
Sun 8/316:14 pmTYS - STL
1 stop4h 48mDelta
Deal found 7/26$199
This FlightHub deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/307:54 pmSTL - TYS
1 stop22h 47mFrontier
Mon 9/17:10 pmTYS - STL
1 stop15h 01mFrontier
Deal found 7/26$215
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/111:15 pmSTL - TYS
1 stop6h 40mAmerican Airlines
Mon 8/186:00 amTYS - STL
1 stop8h 44mAmerican Airlines
Deal found 7/28$234
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1610:35 amSTL - TYS
1 stop8h 36mMultiple Airlines
Sun 10/199:01 pmTYS - STL
3 stops22h 35mMultiple Airlines
Deal found 7/28$313
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/55:30 pmSTL - TYS
1 stop4h 06mUnited Airlines
Mon 9/87:25 pmTYS - STL
2 stops21h 19mUnited Airlines
Deal found 7/25$367

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2025.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

St. Louis

Fly to

Knoxville

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 8/30

6:00 am-1:08 pm

1 stop6h 08m

Knoxville McGhee Tyson

Sun 8/31

6:14 pm-10:02 pm

1 stop4h 48m

$199

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 8/30

7:54 pm-7:41 pm

1 stop22h 47m

Knoxville McGhee Tyson

Mon 9/1

7:10 pm-9:11 am

1 stop15h 01m

$215

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 8/11

1:15 pm-8:55 pm

1 stop6h 40m

Knoxville McGhee Tyson

Mon 8/18

6:00 am-1:44 pm

1 stop8h 44m

$234

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 10/16

10:35 am-8:11 pm

1 stop8h 36m

Knoxville McGhee Tyson

Sun 10/19

9:01 pm-6:36 pm

3 stops22h 35m

$313

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 9/5

5:30 pm-10:36 pm

1 stop4h 06m

Knoxville McGhee Tyson

Mon 9/8

7:25 pm-3:44 pm

2 stops21h 19m

$367

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 10/15

5:15 pm-11:07 pm

1 stop4h 52m

$126

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 8/7

10:47 am-10:11 am

2 stops22h 24m

$167

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 8/1

5:00 am-10:17 am

1 stop4h 17m

$369

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Best time to book a flight from St. Louis to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Knoxville

How far ahead should I book a flight from St. Louis to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Knoxville. Price data was last updated on July 25, 2025.

The price you pay for your flight from St. Louis to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 16 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from St. Louis to Knoxville?

Currently, January is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $295). Flying from St. Louis to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to TYS?

Find hourly flight availability from St. Louis to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 28, 2025.

When flying from St. Louis to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 28% versus a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 28, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from St. Louis to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,971 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,971 reviews
Delta
8.0
Very good
7,971 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,893 reviews
Delta
8.0
Very good
7,971 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,971 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Frontier
5.9
Fair
3,238 reviews
Delta
8.0
Very good
7,971 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from St. Louis to Knoxville round-trip?

    According to our current data, Delta ($199), Frontier ($215), and American Airlines ($234) offers the cheapest pricing from St. Louis to Knoxville. Delta is priced at 41% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from St. Louis to Knoxville that include hotel bookings?

    Yes. In addition to deals on St. Louis to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Knoxville.

  • Can I find deals for business class flights from St. Louis to Knoxville?

    Yes. Cheapflights offers flight deals from St. Louis to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $295). Flying from St. Louis to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Corbin
Cherokee
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from St. Louis to Knoxville

Discover the top 3 airlines that operate flights from St. Louis to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$213Average$378FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$213Average$313FlexibilityNo cancel feeOn-time71%
DeltaCheapest$222Average$291FlexibilityNo cancel feeOn-timeN/A

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