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Knoxville

$83+ Cheap flights from St. Louis to Knoxville (STL - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Knoxville McGhee Tyson are usually found in July or November, booked 16 days in advance, depart on a Thursday or Wednesday and return on a Wednesday

Cheap flight deals from St. Louis to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$165
(American Airlines)

One-way from

$83
(American Airlines)

Popular in

December

Cheapest in

July

Average price

$464
From Lambert-St Louis to Knoxville McGhee Tyson
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One-way flight from Lambert-St Louis to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 10% potential increase in price ($41 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from St. Louis to Knoxville

Cheapest flights from St. Louis to Knoxville
Explore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/116:00 amSTL - TYS
1 stop5h 43mAmerican Airlines
Sat 11/155:10 amTYS - STL
1 stop6h 29mAmerican Airlines
Deal found 9/10$165
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/265:18 amSTL - TYS
1 stop6h 54mAmerican Airlines
Tue 9/307:45 pmTYS - STL
1 stop4h 22mAmerican Airlines
Deal found 9/11$212
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/212:31 pmSTL - TYS
1 stop7h 02mUnited Airlines
Tue 11/45:52 pmTYS - STL
1 stop5h 53mUnited Airlines
Deal found 9/10$226
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/85:20 amSTL - TYS
1 stop5h 25mAmerican Airlines
Wed 10/157:43 pmTYS - STL
1 stop4h 22mAmerican Airlines
Deal found 9/11$249
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/254:00 pmSTL - TYS
2 stops29h 21mMultiple Airlines
Mon 9/298:35 pmTYS - STL
1 stop13h 31mMultiple Airlines
Deal found 9/10$250
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/275:18 amSTL - TYS
1 stop6h 54mAmerican Airlines
Thu 10/25:05 amTYS - STL
1 stop4h 00mAmerican Airlines
Deal found 9/11$254
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/105:28 pmSTL - TYS
1 stop4h 22mUnited Airlines
Fri 10/177:00 amTYS - STL
1 stop4h 49mUnited Airlines
Deal found 9/10$255
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/246:29 amSTL - TYS
1 stop4h 21mAmerican Airlines
Sun 9/288:36 pmTYS - STL
1 stop4h 17mAmerican Airlines
Deal found 9/10$259
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/254:00 pmSTL - TYS
2 stops17h 33mMultiple Airlines
Sat 9/274:31 pmTYS - STL
1 stop18h 09mMultiple Airlines
Deal found 9/10$281
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:52 pmSTL - TYS
1 stop3h 54mDelta
Sun 10/198:35 pmTYS - STL
1 stop4h 06mDelta
Deal found 9/10$287
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/224:00 pmSTL - TYS
2 stops17h 35mMultiple Airlines
Thu 9/257:00 amTYS - STL
1 stop27h 06mMultiple Airlines
Deal found 9/11$293
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/265:18 amSTL - TYS
1 stop6h 54mAmerican Airlines
Sun 9/288:36 pmTYS - STL
1 stop4h 17mAmerican Airlines
Deal found 9/10$299

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

St. Louis

Fly to

Knoxville

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 9/26

5:18 am-1:12 pm

1 stop6h 54m

Knoxville McGhee Tyson

Tue 9/30

7:45 pm-11:07 pm

1 stop4h 22m

$212

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 12/2

6:40 am-11:45 am

1 stop4h 05m

Knoxville McGhee Tyson

Sun 12/7

7:59 pm-11:41 pm

1 stop4h 42m

$226

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 11/2

12:31 pm-8:33 pm

1 stop7h 02m

Knoxville McGhee Tyson

Tue 11/4

5:52 pm-10:45 pm

1 stop5h 53m

$226

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 10/8

5:20 am-11:45 am

1 stop5h 25m

Knoxville McGhee Tyson

Wed 10/15

7:43 pm-11:05 pm

1 stop4h 22m

$249

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 9/25

4:00 pm-10:21 pm

2 stops29h 21m

Knoxville McGhee Tyson

Mon 9/29

8:35 pm-9:06 am

1 stop13h 31m

$250

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 9/27

5:18 am-1:12 pm

1 stop6h 54m

Knoxville McGhee Tyson

Thu 10/2

5:05 am-8:05 am

1 stop4h 00m

$254

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 9/24

6:10 am-12:21 pm

1 stop5h 11m

Knoxville McGhee Tyson

Sat 9/27

4:49 pm-8:32 pm

1 stop4h 43m

$259

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 9/22

4:00 pm-10:35 am

2 stops17h 35m

Knoxville McGhee Tyson

Thu 9/25

7:00 am-9:06 am

1 stop27h 06m

$293

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 9/26

5:18 am-1:12 pm

1 stop6h 54m

Knoxville McGhee Tyson

Sun 9/28

8:36 pm-11:53 pm

1 stop4h 17m

$299

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 10/23

12:25 pm-5:18 pm

1 stop3h 53m

Knoxville McGhee Tyson

Mon 10/27

6:45 am-10:51 am

1 stop5h 06m

$315

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 18 results
1
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Best time to book a flight from St. Louis to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Knoxville

How far ahead should I book a flight from St. Louis to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Knoxville. Price data was last updated on August 29, 2025.

The price you pay for your flight from St. Louis to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 16 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from St. Louis to Knoxville?

Currently, January is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $294). Flying from St. Louis to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to TYS?

Find hourly flight availability from St. Louis to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from St. Louis to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 28% versus a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 11, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from St. Louis to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Knoxville?

    Departing from St. Louis to Knoxville will take you 4h 05m. St. Louis and Knoxville are separated by a distance of 405 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from St. Louis to Knoxville round-trip?

    According to our current data, American Airlines ($213), United Airlines ($213), and Delta ($222) offers the cheapest pricing from St. Louis to Knoxville. American Airlines is priced at 38% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from St. Louis to Knoxville that include hotel bookings?

    Yes. In addition to deals on St. Louis to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Knoxville.

  • Can I find deals for business class flights from St. Louis to Knoxville?

    Yes. Cheapflights offers flight deals from St. Louis to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $294). Flying from St. Louis to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from St. Louis to Knoxville

Discover the top 3 airlines that operate flights from St. Louis to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$213Average$378FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$213Average$300FlexibilityNo cancel feeOn-time71%
DeltaCheapest$222Average$288FlexibilityNo cancel feeOn-timeN/A

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