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Knoxville

$124+ Cheap flights from St. Louis to Knoxville (STL - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/1. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Nov 26 — Dec 31
Wed 11/26
Wed 12/3
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Knoxville McGhee Tyson are usually found in July or April, booked 16 days in advance, depart on a Thursday or Wednesday and return on a Wednesday

Cheap flight deals from St. Louis to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 27, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(Delta)

One-way from

$124
(Mytrip)

Popular in

December

Cheapest in

July

Average price

$381
Provider with most accurate pricing for Lambert-St Louis-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Knoxville McGhee Tyson flights.
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From Lambert-St Louis to Knoxville McGhee Tyson
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One-way flight from Lambert-St Louis to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 9% potential increase in price ($35 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from St. Louis to Knoxville

Cheapest flights from St. Louis to Knoxville
Explore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2025.

This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:00 amSTL - TYS
1 stop5h 42mAmerican Airlines
Tue 12/25:52 pmTYS - STL
1 stop7h 04mAmerican Airlines
Deal found 10/26$249
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:47 pmSTL - TYS
1 stop16h 46mMultiple Airlines
Sun 12/144:52 pmTYS - STL
1 stop18h 22mMultiple Airlines
Deal found 10/26$257
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/169:30 amSTL - TYS
1 stop6h 57mAmerican Airlines
Sun 12/215:42 amTYS - STL
1 stop7h 47mAmerican Airlines
Deal found 10/25$274
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/72:05 pmSTL - TYS
1 stop6h 12mAmerican Airlines
Mon 11/105:03 pmTYS - STL
1 stop5h 16mAmerican Airlines
Deal found 10/25$284
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/96:21 pmSTL - TYS
1 stop22h 00mMultiple Airlines
Thu 11/139:54 amTYS - STL
1 stop9h 03mMultiple Airlines
Deal found 10/25$285
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/510:42 amSTL - TYS
2 stops24h 21mMultiple Airlines
Mon 12/86:30 amTYS - STL
1 stop17h 03mMultiple Airlines
Deal found 10/24$290
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/37:05 amSTL - TYS
1 stop5h 37mDelta
Mon 11/108:07 pmTYS - STL
1 stop4h 37mDelta
Deal found 10/26$294
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/215:00 amSTL - TYS
1 stop4h 19mAmerican Airlines
Sun 11/235:05 amTYS - STL
1 stop4h 22mAmerican Airlines
Deal found 10/25$298
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/145:56 pmSTL - TYS
1 stop3h 55mAmerican Airlines
Tue 11/185:10 amTYS - STL
1 stop6h 29mAmerican Airlines
Deal found 10/25$304
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/144:56 pmSTL - TYS
2 stops23h 26mMultiple Airlines
Tue 11/184:04 pmTYS - STL
1 stop19h 01mMultiple Airlines
Deal found 10/25$305

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 27, 2025.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

St. Louis

Fly to

Knoxville

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 11/27

6:00 am-12:42 pm

1 stop5h 42m

Knoxville McGhee Tyson

Tue 12/2

5:52 pm-11:56 pm

1 stop7h 04m

$249

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 12/5

2:38 pm-8:00 pm

1 stop4h 22m

Knoxville McGhee Tyson

Mon 12/8

7:59 pm-11:42 pm

1 stop4h 43m

$249

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 2/18

6:45 am-11:47 am

1 stop4h 02m

Knoxville McGhee Tyson

Sat 2/21

12:30 pm-4:55 pm

1 stop5h 25m

$249

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 12/11

2:47 pm-8:33 am

1 stop16h 46m

Knoxville McGhee Tyson

Sun 12/14

4:52 pm-10:14 am

1 stop18h 22m

$257

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 12/16

9:30 am-5:27 pm

1 stop6h 57m

Knoxville McGhee Tyson

Sun 12/21

5:42 am-12:29 pm

1 stop7h 47m

$274

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 1/9

11:55 am-5:42 pm

1 stop4h 47m

Knoxville McGhee Tyson

Mon 1/12

10:11 am-3:04 pm

1 stop5h 53m

$279

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 12/4

7:02 pm-11:28 pm

1 stop3h 26m

Knoxville McGhee Tyson

Sun 12/7

7:59 pm-11:42 pm

1 stop4h 43m

$284

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 11/7

2:05 pm-9:17 pm

1 stop6h 12m

Knoxville McGhee Tyson

Mon 11/10

5:03 pm-9:19 pm

1 stop5h 16m

$284

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 12/5

10:42 am-12:03 pm

2 stops24h 21m

Knoxville McGhee Tyson

Mon 12/8

6:30 am-10:33 pm

1 stop17h 03m

$290

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 11/1

8:40 pm-7:07 pm

1 stop21h 27m

$124

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/26

Showing 1-10 of 16 results
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Compare providers for flights from St. Louis to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Knoxville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on St. Louis-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from St. Louis-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Knoxville

How far ahead should I book a flight from St. Louis to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Knoxville. Price data was last updated on October 24, 2025.

The price you pay for your flight from St. Louis to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 16 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from St. Louis to Knoxville?

Currently, August is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $149). Flying from St. Louis to Knoxville in March is currently the most expensive (average of $239). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to TYS?

Find hourly flight availability from St. Louis to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 27, 2025.

When flying from St. Louis to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 27% versus a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 27, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from St. Louis to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,996 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Overall

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,996 reviews
Delta
7.9
Good
7,996 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Overall

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,997 reviews
Delta
7.9
Good
7,996 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Overall

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,033 reviews
Delta
7.9
Good
7,996 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Overall

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Knoxville?

    Departing from St. Louis to Knoxville will take you 4h 22m. St. Louis and Knoxville are separated by a distance of 405 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from St. Louis to Knoxville round-trip?

    According to our current data, United Airlines ($213), American Airlines ($218), and Delta ($228) offers the cheapest pricing from St. Louis to Knoxville. United Airlines is priced at 35% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from St. Louis to Knoxville that include hotel bookings?

    Yes. In addition to deals on St. Louis to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Knoxville.

  • Can I find deals for business class flights from St. Louis to Knoxville?

    Yes. Cheapflights offers flight deals from St. Louis to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $149). Flying from St. Louis to Knoxville in March is currently the most expensive (average of $239). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from St. Louis to Knoxville

Discover the top 3 airlines that operate flights from St. Louis to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 27, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$213Average$378FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$299FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$295FlexibilityNo cancel feeOn-timeN/A

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