$129+ Cheap flights from St. Louis to Knoxville (STL - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/2. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Apr 11 — Apr 181
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Knoxville
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Best
Last-minute
One-way
Cheapest flights from St. Louis to KnoxvilleExplore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.
Explore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/52:30 pm
STL
- TYS
1 stop4h 10m
Southwest
Tue 5/1212:50 pm
TYS
- STL
1 stop8h 05m
Southwest
Deal found 3/9![Southwest logo]()
$233
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:15 am
STL
- TYS
2 stops8h 05m
Southwest
Tue 4/75:50 pm
TYS
- STL
1 stop5h 10m
Southwest
Deal found 3/10![Southwest logo]()
$238
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:51 am
STL
- TYS
1 stop4h 27m
American Airlines
Sat 4/117:50 am
TYS
- STL
1 stop7h 13m
American Airlines
Deal found 3/10![American Airlines logo]()
$245
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:20 am
STL
- TYS
1 stop6h 00m
Southwest
Wed 4/297:05 am
TYS
- STL
2 stops8h 45m
Southwest
Deal found 3/11![Southwest logo]()
$250
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:10 am
STL
- TYS
1 stop6h 30m
Southwest
Fri 4/106:45 pm
TYS
- STL
1 stop3h 10m
Southwest
Deal found 3/9![Southwest logo]()
$256
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/252:25 pm
STL
- TYS
1 stop3h 05m
Southwest
Sat 5/26:40 am
TYS
- STL
2 stops10h 45m
Southwest
Deal found 3/11![Southwest logo]()
$262
Best flights from St. Louis to KnoxvilleDiscover carefully curated flight deals from St. Louis to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 12, 2026.
Discover carefully curated flight deals from St. Louis to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 12, 2026.
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/53:24 pm
STL
- TYS
1 stop5h 02m
American Airlines
Tue 5/127:53 am
TYS
- STL
1 stop4h 54m
American Airlines
Deal found 3/12![American Airlines logo]()
$233
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:15 am
STL
- TYS
2 stops8h 05m
Southwest
Wed 4/85:50 pm
TYS
- STL
1 stop5h 10m
Southwest
Deal found 3/10![Southwest logo]()
$238
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/119:21 am
STL
- TYS
1 stop6h 33m
United Airlines
Thu 5/146:01 pm
TYS
- STL
1 stop4h 12m
United Airlines
Deal found 3/11![United Airlines logo]()
$257
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:15 am
STL
- TYS
2 stops8h 05m
Southwest
Tue 4/75:50 pm
TYS
- STL
1 stop5h 10m
Southwest
Deal found 3/10![Southwest logo]()
$238
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:15 am
STL
- TYS
2 stops8h 25m
Southwest
Tue 5/127:05 am
TYS
- STL
2 stops6h 55m
Southwest
Deal found 3/9![Southwest logo]()
$243
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/28:45 am
STL
- TYS
1 stop5h 35m
Southwest
Mon 5/46:45 pm
TYS
- STL
1 stop3h 10m
Southwest
Deal found 3/9![Southwest logo]()
$257
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/252:25 pm
STL
- TYS
1 stop3h 05m
Southwest
Sat 5/26:40 am
TYS
- STL
2 stops10h 45m
Southwest
Deal found 3/11![Southwest logo]()
$262
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/252:10 pm
STL
- TYS
1 stop6h 00m
Southwest
Tue 6/302:45 pm
TYS
- STL
1 stop7h 55m
Southwest
Deal found 3/8![Southwest logo]()
$279
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:10 pm
STL
- TYS
2 stops6h 05m
Southwest
Thu 5/146:35 am
TYS
- STL
2 stops9h 20m
Southwest
Deal found 3/11![Southwest logo]()
$283
Last-minute flights from St. Louis to KnoxvilleDiscover last-minute flight deals from St. Louis to Knoxville. Data last updated March 12, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Knoxville. Data last updated March 12, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:10 am
STL
- TYS
1 stop6h 30m
Southwest
Fri 4/106:45 pm
TYS
- STL
1 stop3h 10m
Southwest
Deal found 3/9![Southwest logo]()
$256
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:00 am
STL
- TYS
1 stop4h 18m
American Airlines
Tue 4/76:54 pm
TYS
- STL
1 stop5h 05m
American Airlines
Deal found 3/10![American Airlines logo]()
$233
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:15 am
STL
- TYS
2 stops8h 05m
Southwest
Tue 4/75:50 pm
TYS
- STL
1 stop5h 10m
Southwest
Deal found 3/10![Southwest logo]()
$238
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:51 am
STL
- TYS
1 stop4h 27m
American Airlines
Sat 4/117:50 am
TYS
- STL
1 stop7h 13m
American Airlines
Deal found 3/10![American Airlines logo]()
$245
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:11 pm
STL
- TYS
1 stop4h 45m
American Airlines
Sun 4/197:00 am
TYS
- STL
1 stop6h 48m
American Airlines
Deal found 3/9![American Airlines logo]()
$268
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:20 am
STL
- TYS
1 stop6h 00m
Southwest
Wed 4/297:05 am
TYS
- STL
2 stops8h 45m
Southwest
Deal found 3/11![Southwest logo]()
$250
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/252:25 pm
STL
- TYS
1 stop3h 05m
Southwest
Sat 5/26:40 am
TYS
- STL
2 stops10h 45m
Southwest
Deal found 3/11![Southwest logo]()
$262
One-way flights from St. Louis to KnoxvilleSearch for one-way flight options from St. Louis to Knoxville. Find affordable one-way fares based on user searches. Data last updated March 12, 2026.
Search for one-way flight options from St. Louis to Knoxville. Find affordable one-way fares based on user searches. Data last updated March 12, 2026.
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/25:12 am
STL
- TYS
1 stop5h 18m
American Airlines
Deal found 3/9![American Airlines logo]()
$129
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/910:50 am
STL
- TYS
2 stops8h 30m
Southwest
Deal found 3/9![Southwest logo]()
$134
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:00 am
STL
- TYS
1 stop3h 59m
American Airlines
Deal found 3/8![American Airlines logo]()
$140
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/25:30 am
STL
- TYS
2 stops6h 15m
Southwest
Deal found 3/9![Southwest logo]()
$174
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/158:23 pm
STL
- TYS
3 stops39h 53m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/99:50 am
STL
- TYS
3 stops34h 58m
Multiple Airlines
Deal found 3/7![Multiple Airlines logo]()
$228
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:41 pm
STL
- TYS
1 stop5h 49m
United Airlines
Deal found 3/6![United Airlines logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/210:12 pm
STL
- TYS
3 stops33h 24m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:44 pm
STL
- TYS
3 stops22h 56m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/233:48 pm
STL
- TYS
3 stops43h 58m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$288
Find flight deals from St. Louis to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $233 (Southwest) |
One-way from | $129 (American Airlines) |
Popular in | January |
Cheapest in | July |
Average price | $356 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Tue 5/5
3:24 pm-9:26 pm
1 stop5h 02m
Knoxville McGhee Tyson
Tue 5/12
7:53 am-11:47 am
1 stop4h 54m
$233
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Wed 4/8
5:15 am-2:20 pm
2 stops8h 05m
Knoxville McGhee Tyson
Wed 4/8
5:50 pm-10:00 pm
1 stop5h 10m
$238
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Tue 4/7
5:15 am-2:20 pm
2 stops8h 05m
Knoxville McGhee Tyson
Tue 4/7
5:50 pm-10:00 pm
1 stop5h 10m
$238
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Tue 5/5
10:15 am-7:40 pm
2 stops8h 25m
Knoxville McGhee Tyson
Tue 5/12
7:05 am-1:00 pm
2 stops6h 55m
$243
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Mon 5/11
9:21 am-4:54 pm
1 stop6h 33m
Knoxville McGhee Tyson
Thu 5/14
6:01 pm-9:13 pm
1 stop4h 12m
$257
Quickest round-trip
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Sat 5/2
8:45 am-3:20 pm
1 stop5h 35m
Knoxville McGhee Tyson
Mon 5/4
6:45 pm-8:55 pm
1 stop3h 10m
$257
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Sat 4/25
2:25 pm-6:30 pm
1 stop3h 05m
Knoxville McGhee Tyson
Sat 5/2
6:40 am-4:25 pm
2 stops10h 45m
$262
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Thu 6/25
2:10 pm-9:10 pm
1 stop6h 00m
Knoxville McGhee Tyson
Tue 6/30
2:45 pm-9:40 pm
1 stop7h 55m
$279
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Mon 5/11
2:10 pm-9:15 pm
2 stops6h 05m
Knoxville McGhee Tyson
Thu 5/14
6:35 am-2:55 pm
2 stops9h 20m
$283
Cheapest one-way
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Sat 5/23
9:23 am-4:51 pm
1 stop6h 28m
$129
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Knoxville in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from St. Louis with our price prediction graph.
STL-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Knoxville
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated March 12, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from St. Louis to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Overall
7.9
Crew
8.5
Food
7.2
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Overall
7.9
Crew
8.5
Food
7.2
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Overall
7.9
Crew
8.5
Food
7.2
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Overall
7.9
Crew
8.5
Food
7.2
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 12, 2026.
St. Louis and Knoxville flights
Browse other St. Louis and Knoxville flight options. Last updated on March 12, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on March 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from St. Louis to Knoxville
Discover the top 3 airlines that operate flights from St. Louis to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$213 | Average$315 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$213 | Average$297 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$222 | Average$313 | FlexibilityNo cancel fee | On-timeN/A |