What are the cheapest airlines flying from St. Louis to Knoxville round-trip?

According to our current data, Delta ($229), American Airlines ($234), and United Airlines ($374) offers the cheapest pricing from St. Louis to Knoxville. Delta is priced at 32% lower than the current average price of a flight leaving 3 months from now.

What are the cheapest airlines to fly from St. Louis to Knoxville one-way?

For one-way options, check prices for Delta. According to our data, you can fly for as low as $100. Users have also found prices from $185 and $194 on American Airlines and Frontier, respectively.

What are the most popular airlines that fly from St. Louis to Knoxville?

American Airlines, Delta and United Airlines are the most popular airlines when flying from St. Louis to Knoxville.

What is the cheapest day to fly round-trip from St. Louis to Knoxville?

Wednesday is generally a great day to depart. Flying on this day could help you save up to 88%.

What is the cheapest month to fly from St. Louis to Knoxville?

July is one of the best times of the year to fly to Knoxville from St. Louis. Prices for July average $340 per person but you can even find prices for as low as $172. The most expensive prices can be found in the month of December. Opting for a July flight can save you 52% on your journey compared to booking in December

Can I find deals for flights from St. Louis to Knoxville that include hotel bookings?

Yes. In addition to deals on St. Louis to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from St. Louis to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Knoxville.

Can I find deals for business class flights from St. Louis to Knoxville?

Yes. Cheapflights offers flight deals from St. Louis to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$100+ Flights from St. Louis to Knoxville

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1. Tell us where you want to go

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2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

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Cheapflights Tip: The best prices from Lambert-St Louis to Knoxville McGhee Tyson are usually found in July or November, booked 46 days in advance, depart on a Thursday or Wednesday and return on a Wednesday

Cheap flight deals from St. Louis to Knoxville

Round-trip from	$229 (Delta)
One-way from	$100 (Delta)
Popular in	December
Cheapest in	July
Average price	$264

From Lambert-St Louis to Knoxville McGhee Tyson

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One-way flight from Lambert-St Louis to Knoxville McGhee Tyson

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Highest demand for flights based on searches. 11% potential increase in price ($45 potential increase over avg. RT price).

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Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Find flight deals from St. Louis to Knoxville

Cheapest flights from St. Louis to Knoxville
Explore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Tue 7/89:27 amSTL - TYS

1 stop4h 40mDelta

Sat 7/125:30 amTYS - STL

1 stop4h 31mDelta

Deal found 6/10

$229

Tue 7/85:27 pmSTL - TYS

1 stop5h 25mAmerican Airlines

Sat 7/128:22 pmTYS - STL

1 stop4h 37mAmerican Airlines

Deal found 6/10

$234

Thu 7/175:26 pmSTL - TYS

1 stop13h 36mMultiple Airlines

Mon 7/216:00 amTYS - STL

2 stops35h 31mMultiple Airlines

Deal found 6/10

$270

Fri 8/155:30 pmSTL - TYS

1 stop4h 07mUnited Airlines

Fri 8/227:25 pmTYS - STL

2 stops16h 15mUnited Airlines

Deal found 6/11

$374

Best flights from St. Louis to Knoxville
Discover carefully curated flight deals from St. Louis to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2025.

Tue 7/81:29 pmSTL - TYS

1 stop4h 32mDelta

Tue 7/155:12 pmTYS - STL

1 stop4h 24mDelta

Deal found 6/10

$229

Tue 7/85:27 pmSTL - TYS

1 stop5h 25mAmerican Airlines

Sat 7/128:22 pmTYS - STL

1 stop4h 37mAmerican Airlines

Deal found 6/10

$234

Thu 7/175:26 pmSTL - TYS

1 stop13h 36mMultiple Airlines

Mon 7/216:00 amTYS - STL

2 stops35h 31mMultiple Airlines

Deal found 6/10

$270

Fri 8/155:30 pmSTL - TYS

1 stop4h 07mUnited Airlines

Fri 8/227:25 pmTYS - STL

2 stops16h 15mUnited Airlines

Deal found 6/11

$374

Last-minute flights from St. Louis to Knoxville
Discover last-minute flight deals from St. Louis to Knoxville. Data last updated June 12, 2025 and is based on user searches.

Wed 6/1811:47 amSTL - TYS

1 stop5h 14mAmerican Airlines

Wed 6/187:53 pmTYS - STL

1 stop5h 06mAmerican Airlines

Deal found 6/10

$637

Wed 6/186:30 amSTL - TYS

1 stop5h 51mUnited Airlines

Wed 6/182:25 pmTYS - STL

2 stops9h 20mUnited Airlines

Deal found 6/10

$978

Sun 6/226:36 pmSTL - TYS

2 stops20h 35mMultiple Airlines

Thu 6/269:04 pmTYS - STL

1 stop14h 29mMultiple Airlines

Deal found 6/9

$431

Sun 6/225:30 pmSTL - TYS

1 stop5h 29mDelta

Thu 6/2612:03 pmTYS - STL

1 stop5h 22mDelta

Deal found 6/9

$590

Tue 7/89:27 amSTL - TYS

1 stop4h 40mDelta

Sat 7/125:30 amTYS - STL

1 stop4h 31mDelta

Deal found 6/10

$229

Tue 7/85:27 pmSTL - TYS

1 stop5h 25mAmerican Airlines

Sat 7/128:22 pmTYS - STL

1 stop4h 37mAmerican Airlines

Deal found 6/10

$234

Tue 7/85:31 pmSTL - TYS

1 stop4h 04mUnited Airlines

Tue 7/159:55 amTYS - STL

2 stops12h 40mUnited Airlines

Deal found 6/10

$418

Thu 7/175:26 pmSTL - TYS

1 stop13h 36mMultiple Airlines

Mon 7/216:00 amTYS - STL

2 stops35h 31mMultiple Airlines

Deal found 6/10

$270

One-way flights from St. Louis to Knoxville
Search for one-way flight options from St. Louis to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 12, 2025.

Fri 7/45:23 pmSTL - TYS

1 stop3h 48mDelta

Deal found 6/10

$100

Sat 7/263:34 pmSTL - TYS

1 stop27h 30mMultiple Airlines

Deal found 6/11

$114

Fri 7/46:00 amSTL - TYS

2 stops7h 20mAmerican Airlines

Deal found 6/10

$185

Wed 7/167:29 pmSTL - TYS

1 stop20h 00mFrontier

Deal found 6/10

$194

Fri 8/155:30 pmSTL - TYS

2 stops15h 57mUnited Airlines

Deal found 6/11

$280

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 7/8

1:29 pm-7:01 pm

1 stop4h 32m

Knoxville McGhee Tyson

Tue 7/15

5:12 pm-8:36 pm

1 stop4h 24m

$229

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 7/8

5:27 pm-11:52 pm

1 stop5h 25m

Knoxville McGhee Tyson

Sat 7/12

8:22 pm-11:59 pm

1 stop4h 37m

$234

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 7/17

5:26 pm-8:02 am

1 stop13h 36m

Knoxville McGhee Tyson

Mon 7/21

6:00 am-4:31 pm

2 stops35h 31m

$270

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 8/15

5:30 pm-10:37 pm

1 stop4h 07m

Knoxville McGhee Tyson

Fri 8/22

7:25 pm-10:40 am

2 stops16h 15m

$374

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 7/4

5:23 pm-10:11 pm

1 stop3h 48m

$100

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 7/26

3:34 pm-8:04 pm

1 stop27h 30m

$114

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 7/4

6:00 am-2:20 pm

2 stops7h 20m

$185

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 7/16

7:29 pm-4:29 pm

1 stop20h 00m

$194

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 8/15

5:30 pm-10:27 am

2 stops15h 57m

$280

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from St. Louis to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from St. Louis with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Knoxville

What is the cheapest month to book a flight from St. Louis to Knoxville?

Currently, January is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $296). Flying from St. Louis to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to TYS?

When flying from St. Louis to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 28% versus a flight at noon.

What is the cheapest day to fly from St. Louis to Knoxville?

Travelers seeking maximum savings on their St. Louis to Knoxville flight should consider departing on Thursday evenings when fares are most often at their lowest. Thursday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in Knoxville by month

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

To help decide which airline to fly from St. Louis to Knoxville, see what other customers have to say about Delta, United Airlines and American Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,950 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,790 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Frontier

5.9

Fair

3,295 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from St. Louis to Knoxville round-trip?
According to our current data, Delta ($229), American Airlines ($234), and United Airlines ($374) offers the cheapest pricing from St. Louis to Knoxville. Delta is priced at 32% lower than the current average price of a flight leaving 3 months from now.
What are the cheapest airlines to fly from St. Louis to Knoxville one-way?
For one-way options, check prices for Delta. According to our data, you can fly for as low as $100. Users have also found prices from $185 and $194 on American Airlines and Frontier, respectively.
Can I find deals for flights from St. Louis to Knoxville that include hotel bookings?
Yes. In addition to deals on St. Louis to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from St. Louis to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Knoxville.
Can I find deals for business class flights from St. Louis to Knoxville?
Yes. Cheapflights offers flight deals from St. Louis to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from St. Louis to Knoxville?
Currently, January is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $296). Flying from St. Louis to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Morristown

Cherokee

Corbin

Maryville

Oak Ridge

Alcoa

Murphy

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from St. Louis to Knoxville

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$213	Average$378	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$213	Average$323	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$222	Average$292	FlexibilityNo cancel fee	On-timeN/A

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$100+ Cheap flights from St. Louis to Knoxville (STL - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/4. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from St. Louis to Knoxville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Lambert-St Louis to Knoxville McGhee Tyson are usually found in July or November, booked 46 days in advance, depart on a Thursday or Wednesday and return on a Wednesday

Cheap flight deals from St. Louis to Knoxville

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from St. Louis to Knoxville

Cheapest flights from St. Louis to KnoxvilleExplore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Explore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Best time to book a flight from St. Louis to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from St. Louis with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Knoxville

What is the cheapest month to book a flight from St. Louis to Knoxville?

What is the cheapest time of day to fly from STL to TYS?

Find hourly flight availability from St. Louis to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

What is the cheapest day to fly from St. Louis to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from St. Louis to Knoxville. Price data was last updated on December 16, 2024.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

Reviews of airlines servicing Knoxville

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from St. Louis to Knoxville round-trip?

What are the cheapest airlines to fly from St. Louis to Knoxville one-way?

Can I find deals for flights from St. Louis to Knoxville that include hotel bookings?

How can I find direct flights from St. Louis to Knoxville?

Can I find deals for business class flights from St. Louis to Knoxville?

What is the cheapest month to book a flight from St. Louis to Knoxville?

Traveling to a place near St. Louis?

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Alternative routes for St. Louis to Knoxville

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Top 3 airlines flying from St. Louis to Knoxville

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Cheapest flights from St. Louis to Knoxville
Explore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.