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Knoxville

$140+ Cheap flights from St. Louis to Knoxville (STL - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/3. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Feb 23 — Mar 21
Mon 2/23
Mon 3/2
1 adult, Economy
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Cheap flight deals from St. Louis to Knoxville

Cheapest flights from St. Louis to Knoxville
Explore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 24, 2026.

This Delta deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:13 am
STL
-
TYS
1 stop4h 02m
Delta
Wed 3/115:10 pm
TYS
-
STL
1 stop4h 56m
Delta
Deal found 1/22$233
This Kiwi.com deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/33:49 pm
STL
-
TYS
1 stop25h 37m
Multiple Airlines
Sun 3/87:20 am
TYS
-
STL
2 stops30h 59m
Multiple Airlines
Deal found 1/23$250
This Southwest deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/52:35 pm
STL
-
TYS
1 stop5h 40m
Southwest
Fri 3/67:25 pm
TYS
-
STL
1 stop5h 40m
Southwest
Deal found 1/23$257
This Southwest deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/238:45 am
STL
-
TYS
1 stop9h 00m
Southwest
Sat 3/286:35 am
TYS
-
STL
2 stops8h 20m
Southwest
Deal found 1/21$268
This Delta deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:30 pm
STL
-
TYS
1 stop5h 17m
Delta
Tue 9/224:00 pm
TYS
-
STL
1 stop5h 50m
Delta
Deal found 1/22$279
This Southwest deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:55 pm
STL
-
TYS
1 stop3h 20m
Southwest
Fri 4/106:35 am
TYS
-
STL
2 stops8h 45m
Southwest
Deal found 1/23$284
This Southwest deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:35 am
STL
-
TYS
1 stop3h 05m
Southwest
Mon 6/16:35 am
TYS
-
STL
1 stop7h 40m
Southwest
Deal found 1/22$285
This American Airlines deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/275:12 am
STL
-
TYS
1 stop5h 19m
American Airlines
Mon 3/25:02 pm
TYS
-
STL
1 stop5h 35m
American Airlines
Deal found 1/22$287

Find flight deals from St. Louis to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$233
(Delta)

One-way from

$140
(United Airlines)

Popular in

January

Cheapest in

July

Average price

$416
Provider with most accurate pricing for Lambert-St Louis-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Knoxville McGhee Tyson flights.
Search Deals
From Lambert-St Louis to Knoxville McGhee Tyson
Search Deals
One-way flight from Lambert-St Louis to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($23 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 24, 2026.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

St. Louis

Fly to

Knoxville

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 3/4

10:13 am-3:15 pm

1 stop4h 02m

Knoxville McGhee Tyson

Wed 3/11

5:10 pm-9:06 pm

1 stop4h 56m

$233

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 3/23

6:59 pm-11:57 pm

1 stop3h 58m

Knoxville McGhee Tyson

Sat 3/28

5:40 am-9:02 am

1 stop4h 22m

$235

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 3/30

2:35 pm-9:15 pm

1 stop5h 40m

Knoxville McGhee Tyson

Thu 4/2

3:45 pm-10:10 pm

1 stop7h 25m

$257

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 3/5

2:15 pm-9:15 pm

2 stops6h 00m

Knoxville McGhee Tyson

Fri 3/6

7:25 pm-12:05 am

1 stop5h 40m

$262

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 3/26

10:25 am-6:45 pm

1 stop7h 20m

Knoxville McGhee Tyson

Sat 3/28

6:35 am-1:55 pm

2 stops8h 20m

$262

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 3/23

8:45 am-6:45 pm

1 stop9h 00m

Knoxville McGhee Tyson

Sat 3/28

6:35 am-1:55 pm

2 stops8h 20m

$268

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 4/6

6:59 pm-11:57 pm

1 stop3h 58m

Knoxville McGhee Tyson

Fri 4/10

6:38 pm-11:58 pm

1 stop6h 20m

$279

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 4/6

4:55 pm-9:15 pm

1 stop3h 20m

Knoxville McGhee Tyson

Fri 4/10

6:35 am-2:20 pm

2 stops8h 45m

$284

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 4/3

9:10 am-4:52 pm

1 stop6h 42m

$140

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 3/21

5:35 am-1:10 pm

2 stops6h 35m

$145

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/23

Showing 1-10 of 18 results
1
2

Compare providers for flights from St. Louis to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Knoxville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Knoxville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Knoxville

How far ahead should I book a flight from St. Louis to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Knoxville. Price data was last updated on January 16, 2026.

The price you pay for your flight from St. Louis to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 16 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from St. Louis to Knoxville?

Currently, June is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $177). Flying from St. Louis to Knoxville in November is currently the most expensive (average of $250). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 24, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from St. Louis to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,110 reviews

Overall

7.9

Food

7.2

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,110 reviews
Delta
7.9
Good
8,110 reviews

Overall

7.9

Food

7.2

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,194 reviews
Delta
7.9
Good
8,110 reviews

Overall

7.9

Food

7.2

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,192 reviews
Delta
7.9
Good
8,110 reviews

Overall

7.9

Food

7.2

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Knoxville?

    Departing from St. Louis to Knoxville will take you 4h 02m. St. Louis and Knoxville are separated by a distance of 405 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from St. Louis to Knoxville round-trip?

    According to our current data, American Airlines ($213), United Airlines ($213), and Delta ($222) offers the cheapest pricing from St. Louis to Knoxville. American Airlines is priced at 34% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from St. Louis to Knoxville that include hotel bookings?

    Yes. In addition to deals on St. Louis to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Knoxville.

  • Can I find deals for business class flights from St. Louis to Knoxville?

    Yes. Cheapflights offers flight deals from St. Louis to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Knoxville?

    Currently, June is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $177). Flying from St. Louis to Knoxville in November is currently the most expensive (average of $250). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from St. Louis to Knoxville

Discover the top 3 airlines that operate flights from St. Louis to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$213Average$315FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$213Average$298FlexibilityNo cancel feeOn-time71%
DeltaCheapest$222Average$310FlexibilityNo cancel feeOn-timeN/A

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