How long is the flight from South Dakota to Knoxville?

American Airlines and United Airlines can get you from South Dakota to Knoxville in just under 4h 54m. Your travel time can differ by up to 41m. The distance between South Dakota and Knoxville is about 863 mi. This flight may include one or multiple stops.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

What are the most popular airlines that fly from South Dakota to Knoxville?

Consider American Airlines, United Airlines or Delta when booking your flight. These represent the most popular airlines when flying from South Dakota to Knoxville.

What is the cheapest time of day to fly from SD to TYS?

When flying from South Dakota to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What airport do you fly into for flights to Knoxville from South Dakota?

Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from South Dakota.

Can I find deals for flights from South Dakota to Knoxville that include hotel bookings?

Yes. In addition to deals on South Dakota to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from South Dakota to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Dakota to Knoxville.

Can I find deals for business class flights from South Dakota to Knoxville?

Yes. Cheapflights offers flight deals from South Dakota to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$196+ Flights from South Dakota to Knoxville

Q: How much does it cost to fly round-trip from South Dakota to Knoxville?

Airfare is below average for this route at the moment. South Dakota to Knoxville flights typically cost between $285 and $577 in January. The cheapest round-trip price found within the last 3 days was $269 on United Airlines (Jan 6-Jan 14).

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Cheap flight deals from South Dakota to Knoxville

Cheapest flights from South Dakota to Knoxville
Explore the most affordable flight options available from South Dakota to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

Sun 12/213:08 pmFSD - TYS

1 stop6h 31mUnited Airlines

Tue 1/611:10 amTYS - FSD

1 stop7h 08mUnited Airlines

Deal found 12/15

$389

Thu 12/187:11 amFSD - TYS

1 stop6h 21mAmerican Airlines

Tue 12/305:23 amTYS - FSD

1 stop8h 05mAmerican Airlines

Deal found 12/15

$402

Sat 12/2011:27 amFSD - TYS

1 stop4h 33mUnited Airlines

Wed 12/244:04 pmTYS - FSD

1 stop8h 51mUnited Airlines

Deal found 12/13

$424

Tue 12/163:42 pmFSD - TYS

1 stop4h 58mAmerican Airlines

Mon 12/295:08 pmTYS - FSD

1 stop7h 51mAmerican Airlines

Deal found 12/15

$452

Sun 12/2110:36 amFSD - TYS

1 stop22h 55mMultiple Airlines

Sun 1/44:26 pmTYS - FSD

1 stop28h 29mMultiple Airlines

Deal found 12/15

$476

Tue 12/231:52 pmFSD - TYS

1 stop7h 37mUnited Airlines

Tue 1/611:10 amTYS - FSD

1 stop7h 08mUnited Airlines

Deal found 12/15

$484

Thu 12/187:30 amFSD - TYS

2 stops11h 20mUnited Airlines

Tue 12/306:45 amTYS - FSD

1 stop5h 07mUnited Airlines

Deal found 12/15

$487

Sun 12/213:08 pmFSD - TYS

1 stop6h 31mUnited Airlines

Wed 12/316:45 amTYS - FSD

1 stop5h 07mUnited Airlines

Deal found 12/15

$489

Fri 12/1911:11 amRAP - TYS

2 stops9h 28mUnited Airlines

Mon 12/224:04 pmTYS - RAP

1 stop7h 55mUnited Airlines

Deal found 12/15

$555

Best flights from South Dakota to Knoxville
Discover carefully curated flight deals from South Dakota to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 15, 2025.

Wed 4/15:19 pmFSD - TYS

1 stop5h 35mAmerican Airlines

Tue 4/75:56 amTYS - FSD

1 stop7h 23mAmerican Airlines

Deal found 12/12

$269

Tue 1/67:30 amFSD - TYS

1 stop4h 54mUnited Airlines

Wed 1/1411:10 amTYS - FSD

2 stops10h 14mUnited Airlines

Deal found 12/15

$274

Sat 1/247:30 amFSD - TYS

1 stop4h 54mUnited Airlines

Wed 1/2811:10 amTYS - FSD

1 stop4h 26mUnited Airlines

Deal found 12/12

$339

Sat 1/245:10 amRAP - TYS

1 stop8h 04mUnited Airlines

Wed 1/288:45 amTYS - RAP

1 stop6h 27mUnited Airlines

Deal found 12/12

$359

Fri 4/1011:46 amRAP - TYS

1 stop5h 40mAmerican Airlines

Tue 4/145:17 amTYS - RAP

1 stop7h 57mAmerican Airlines

Deal found 12/14

$409

Last-minute flights from South Dakota to Knoxville
Discover last-minute flight deals from South Dakota to Knoxville. Data last updated December 15, 2025 and is based on user searches.

Thu 12/187:11 amFSD - TYS

1 stop6h 21mAmerican Airlines

Tue 12/305:23 amTYS - FSD

1 stop8h 05mAmerican Airlines

Deal found 12/15

$402

Fri 12/1911:11 amRAP - TYS

2 stops9h 28mUnited Airlines

Mon 12/224:04 pmTYS - RAP

1 stop7h 55mUnited Airlines

Deal found 12/15

$555

Sun 12/213:08 pmFSD - TYS

1 stop6h 31mUnited Airlines

Tue 1/611:10 amTYS - FSD

1 stop7h 08mUnited Airlines

Deal found 12/15

$389

Fri 1/27:29 pmFSD - TYS

1 stop14h 21mAmerican Airlines

Tue 1/65:15 pmTYS - FSD

1 stop19h 36mAmerican Airlines

Deal found 12/14

$382

Tue 1/67:30 amFSD - TYS

1 stop4h 54mUnited Airlines

Wed 1/141:59 pmTYS - FSD

1 stop4h 19mUnited Airlines

Deal found 12/15

$269

Mon 1/124:17 pmFSD - TYS

1 stop5h 52mDelta

Mon 1/196:30 amTYS - FSD

1 stop4h 52mDelta

Deal found 12/15

$354

Sat 1/241:40 pmFSD - TYS

1 stop7h 51mUnited Airlines

Wed 1/2811:10 amTYS - FSD

1 stop4h 26mUnited Airlines

Deal found 12/14

$339

Sat 1/242:40 pmRAP - TYS

1 stop5h 51mUnited Airlines

Wed 1/288:45 amTYS - RAP

1 stop6h 27mUnited Airlines

Deal found 12/13

$359

One-way flights from South Dakota to Knoxville
Search for one-way flight options from South Dakota to Knoxville. Find affordable one-way fares based on user searches. Data last updated December 15, 2025.

Sat 1/171:40 pmFSD - TYS

1 stop7h 51mUnited Airlines

Deal found 12/13

$196

Wed 1/213:11 pmFSD - TYS

1 stop4h 41mUnited Airlines

Deal found 12/15

$249

Sat 1/1710:50 amFSD - TYS

2 stops7h 34mDelta

Deal found 12/13

$295

Wed 1/214:37 pmFSD - TYS

3 stops52h 44mAllegiant Air

Deal found 12/15

$348

Sat 1/177:20 pmFSD - TYS

3 stops50h 01mAllegiant Air

Deal found 12/13

$398

Find flight deals from South Dakota to Knoxville

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$269 (United Airlines)
One-way from	$196 (United Airlines)
Popular in	June
Cheapest in	October
Average price	$354

Provider with most accurate pricing for Sioux Falls Joe Foss Field-Knoxville McGhee Tyson flight deals.

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From South Dakota to Knoxville McGhee Tyson

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One-way flight from South Dakota to Knoxville McGhee Tyson

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Highest demand for flights based on searches. 12% potential increase in price ($51 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).

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Average for round-trip flights in December 2025

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Cheapflights Fare Finder

Use the filters below to find and compare flights from South Dakota to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 4/1

5:19 pm-11:54 pm

1 stop5h 35m

Knoxville McGhee Tyson

Tue 4/7

5:56 am-12:19 pm

1 stop7h 23m

$269

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 1/6

7:30 am-1:24 pm

1 stop4h 54m

Knoxville McGhee Tyson

Wed 1/14

11:10 am-8:24 pm

2 stops10h 14m

$274

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 1/24

7:30 am-1:24 pm

1 stop4h 54m

Knoxville McGhee Tyson

Wed 1/28

11:10 am-2:36 pm

1 stop4h 26m

$339

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Sat 1/24

5:10 am-3:14 pm

1 stop8h 04m

Knoxville McGhee Tyson

Wed 1/28

8:45 am-1:12 pm

1 stop6h 27m

$359

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Fri 4/10

11:46 am-7:26 pm

1 stop5h 40m

Knoxville McGhee Tyson

Tue 4/14

5:17 am-11:14 am

1 stop7h 57m

$409

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 1/17

1:40 pm-10:31 pm

1 stop7h 51m

$196

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 1/21

6:00 am-12:46 pm

1 stop5h 46m

$249

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 1/21

3:11 pm-8:52 pm

1 stop4h 41m

$249

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 1/17

10:50 am-7:24 pm

2 stops7h 34m

$295

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 1/21

4:37 pm-10:21 pm

3 stops52h 44m

$348

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/13

Showing 1-10 of 11 results

Best time to book a flight from South Dakota to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Dakota with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Dakota to Knoxville

What is the cheapest month to book a flight from South Dakota to Knoxville?

Currently, July is the cheapest month in which you can book a flight from South Dakota to Knoxville (average of $248). Flying from South Dakota to Knoxville in January is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from South Dakota to Knoxville?

Related info for your journey

What airport do you fly into for flights to Knoxville from South Dakota?
Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from South Dakota.
How long is the flight from South Dakota to Knoxville?
American Airlines and United Airlines can get you from South Dakota to Knoxville in just under 4h 54m. Your travel time can differ by up to 41m. The distance between South Dakota and Knoxville is about 863 mi. This flight may include one or multiple stops.
Can I find deals for flights from South Dakota to Knoxville that include hotel bookings?
Yes. In addition to deals on South Dakota to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from South Dakota to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Dakota to Knoxville.
Can I find deals for business class flights from South Dakota to Knoxville?
Yes. Cheapflights offers flight deals from South Dakota to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from South Dakota to Knoxville?
Currently, July is the cheapest month in which you can book a flight from South Dakota to Knoxville (average of $248). Flying from South Dakota to Knoxville in January is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from South Dakota to Knoxville

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$248	Average$406	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$248	Average$323	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$268	Average$410	FlexibilityNo cancel fee	On-time69%

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$196+ Cheap flights from South Dakota to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from South Dakota to Knoxville with Cheapflights

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Cheap flight deals from South Dakota to Knoxville

Cheapest flights from South Dakota to KnoxvilleExplore the most affordable flight options available from South Dakota to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

Explore the most affordable flight options available from South Dakota to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

Find flight deals from South Dakota to Knoxville

Keep the following information in mind while searching for South Dakota to Knoxville flight deals. Data was last updated December 15, 2025.

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Most trusted provider

Round-trip from

One-way from

Popular in

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Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Dakota to Knoxville that are best for you.

Best time to book a flight from South Dakota to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Dakota with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from South Dakota to Knoxville

What is the cheapest month to book a flight from South Dakota to Knoxville?

How much does it cost to fly round-trip from South Dakota to Knoxville?

Related info for your journey

Find useful and relevant information for your journey from South Dakota to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Knoxville from South Dakota?

How long is the flight from South Dakota to Knoxville?

Can I find deals for flights from South Dakota to Knoxville that include hotel bookings?

How can I find direct flights from South Dakota to Knoxville?

Can I find deals for business class flights from South Dakota to Knoxville?

What is the cheapest month to book a flight from South Dakota to Knoxville?

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Alternative routes for South Dakota to Knoxville

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Top 3 airlines flying from South Dakota to Knoxville

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Cheapest flights from South Dakota to Knoxville
Explore the most affordable flight options available from South Dakota to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.