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Knoxville

$93+ Cheap flights from South Dakota to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — TYS
fev 27 — mar 61
sex 2/27
sex 3/6
1 adult, Economy
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Cheap flight deals from South Dakota to Knoxville

Cheapest flights from South Dakota to Knoxville
Explore the most affordable flight options available from South Dakota to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on janeiro 28, 2026.

This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 4/295:28 pm
FSD
-
TYS
1 stop5h 28m
American Airlines
ter 5/55:44 am
TYS
-
FSD
1 stop8h 17m
American Airlines
Deal found 1/26$269
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 2/244:29 pm
RAP
-
TYS
1 stop4h 43m
Delta
ter 3/36:35 am
TYS
-
RAP
1 stop5h 34m
Delta
Deal found 1/26$279
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 8/36:27 am
FSD
-
TYS
1 stop5h 34m
American Airlines
seg 8/1012:20 pm
TYS
-
FSD
1 stop5h 15m
American Airlines
Deal found 1/27$320
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 4/911:44 am
RAP
-
TYS
1 stop7h 51m
American Airlines
ter 4/144:09 pm
TYS
-
RAP
1 stop7h 49m
American Airlines
Deal found 1/27$325
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 4/811:44 am
RAP
-
TYS
2 stops10h 11m
American Airlines
ter 4/145:00 am
TYS
-
RAP
2 stops8h 14m
American Airlines
Deal found 1/27$335
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb 3/75:19 pm
FSD
-
TYS
1 stop6h 09m
American Airlines
sáb 3/145:40 am
TYS
-
FSD
1 stop8h 01m
American Airlines
Deal found 1/26$352
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 4/12:21 pm
RAP
-
TYS
1 stop7h 30m
American Airlines
ter 4/75:44 am
TYS
-
RAP
1 stop8h 54m
American Airlines
Deal found 1/27$370
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 4/86:00 am
RAP
-
TYS
1 stop7h 19m
American Airlines
seg 4/135:06 pm
TYS
-
RAP
1 stop20h 08m
American Airlines
Deal found 1/27$377
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 3/67:42 pm
FSD
-
TYS
1 stop14h 03m
American Airlines
sex 3/135:40 am
TYS
-
FSD
1 stop8h 01m
American Airlines
Deal found 1/26$388
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 8/1310:58 am
FSD
-
TYS
1 stop4h 36m
Delta
dom 8/166:15 pm
TYS
-
FSD
1 stop5h 31m
Delta
Deal found 1/26$389
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 4/2410:45 am
FSD
-
TYS
1 stop10h 03m
Allegiant Air
dom 4/269:32 pm
TYS
-
FSD
1 stop20h 49m
Allegiant Air
Deal found 1/27$391
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 2/59:00 am
FSD
-
TYS
2 stops10h 52m
United Airlines
dom 2/86:45 am
TYS
-
FSD
1 stop5h 02m
United Airlines
Deal found 1/27$395

Find flight deals from South Dakota to Knoxville

Keep the following information in mind while searching for South Dakota to Knoxville flight deals. Data was last updated janeiro 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$269
(American Airlines)

One-way from

$93
(Kiwi.com)

Popular in

June

Cheapest in

October

Average price

$363
Provider with most accurate pricing for Sioux Falls Joe Foss Field-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Sioux Falls Joe Foss Field-Knoxville McGhee Tyson flights.
Search Deals
From South Dakota to Knoxville McGhee Tyson
Search Deals
One-way flight from South Dakota to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($61 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Dakota to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated janeiro 28, 2026.
Use the filters below to find and compare flights from South Dakota to Knoxville that are best for you.

Fly from

South Dakota

Fly to

Knoxville

Route

Depart

Return

Price

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

qua 4/29

5:28 pm-11:56 pm

1 stop5h 28m

Knoxville McGhee Tyson

ter 5/5

5:44 am-1:01 pm

1 stop8h 17m

$269

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

ter 2/24

4:29 pm-11:12 pm

1 stop4h 43m

Knoxville McGhee Tyson

ter 3/3

6:35 am-10:09 am

1 stop5h 34m

$279

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

qua 4/8

11:44 am-9:35 pm

1 stop7h 51m

Knoxville McGhee Tyson

ter 4/14

4:09 pm-9:58 pm

1 stop7h 49m

$279

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

qua 2/11

7:30 am-1:24 pm

1 stop4h 54m

Knoxville McGhee Tyson

dom 2/15

6:45 am-10:46 am

1 stop5h 01m

$320

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

sáb 3/7

5:19 pm-12:28 am

1 stop6h 09m

Knoxville McGhee Tyson

sáb 3/14

5:40 am-12:41 pm

1 stop8h 01m

$352

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

sex 3/6

7:42 pm-10:45 am

1 stop14h 03m

Knoxville McGhee Tyson

sex 3/13

5:40 am-12:41 pm

1 stop8h 01m

$388

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

sex 4/24

10:45 am-9:48 pm

1 stop10h 03m

Knoxville McGhee Tyson

dom 4/26

9:32 pm-5:21 pm

1 stop20h 49m

$391

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

qui 4/9

11:44 am-11:55 pm

2 stops10h 11m

Knoxville McGhee Tyson

ter 4/14

5:00 am-11:14 am

2 stops8h 14m

$391

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

qua 3/25

2:21 pm-11:51 pm

1 stop7h 30m

Knoxville McGhee Tyson

ter 3/31

4:29 pm-10:36 pm

1 stop8h 07m

$399

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

qua 2/11

6:00 am-4:49 pm

2 stops9h 49m

Knoxville McGhee Tyson

dom 2/15

5:40 am-12:41 pm

1 stop8h 01m

$411

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Showing 1-10 of 22 results
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Best time to book a flight from South Dakota to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Dakota with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Dakota to Knoxville

What is the cheapest month to book a flight from South Dakota to Knoxville?

Currently, July is the cheapest month in which you can book a flight from South Dakota to Knoxville (average of $248). Flying from South Dakota to Knoxville in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from South Dakota to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South Dakota?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from South Dakota.

  • How long is the flight from South Dakota to Knoxville?

    American Airlines, Delta, and United Airlines can get you from South Dakota to Knoxville in just under 4h 43m. Your travel time can differ by up to 45m. The distance between South Dakota and Knoxville is about 1155 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from South Dakota to Knoxville that include hotel bookings?

    Yes. In addition to deals on South Dakota to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Dakota to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Dakota to Knoxville.

  • Can I find deals for business class flights from South Dakota to Knoxville?

    Yes. Cheapflights offers flight deals from South Dakota to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Dakota to Knoxville?

    Currently, July is the cheapest month in which you can book a flight from South Dakota to Knoxville (average of $248). Flying from South Dakota to Knoxville in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

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See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Dakota to Knoxville

Discover the top 3 airlines that operate flights from South Dakota to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated janeiro 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$401FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$312FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$268Average$400FlexibilityNo cancel feeOn-time69%

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