How long is the flight from South Dakota to Knoxville?

American Airlines and Delta can get you from South Dakota to Knoxville in just under 5h 41m. Your travel time can differ by up to 1h 31m. The distance between South Dakota and Knoxville is about 863 mi. This flight may include one or multiple stops.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

What are the most popular airlines that fly from South Dakota to Knoxville?

Consider American Airlines, United Airlines or Delta when booking your flight. These represent the most popular airlines when flying from South Dakota to Knoxville.

What airport do you fly into for flights to Knoxville from South Dakota?

Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from South Dakota.

Can I find deals for flights from South Dakota to Knoxville that include hotel bookings?

Yes. In addition to deals on South Dakota to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from South Dakota to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Dakota to Knoxville.

Can I find deals for business class flights from South Dakota to Knoxville?

Yes. Cheapflights offers flight deals from South Dakota to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$254+ Cheap Flights from South Dakota to Knoxville

Q: How much does it cost to fly round-trip from South Dakota to Knoxville?

Airfare is below average for this route at the moment. South Dakota to Knoxville flights typically cost between $272 and $381 in November. The cheapest round-trip price found within the last 3 days was $254 on American Airlines (Nov 8-Nov 12).

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Find flight deals from South Dakota to Knoxville

Cheapest flights from South Dakota to Knoxville
Explore the most affordable flight options available from South Dakota to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 23, 2025.

sáb. 11/85:27 pmFSD - TYS

1 stop5h 41mAmerican Airlines

mié. 11/126:16 pmTYS - FSD

1 stop5h 11mAmerican Airlines

Deal found 10/21

$254

sáb. 10/255:05 pmFSD - TYS

1 stop6h 18mAmerican Airlines

mar. 10/287:05 amTYS - FSD

1 stop6h 40mAmerican Airlines

Deal found 10/21

$329

jue. 12/1810:36 amFSD - TYS

1 stop22h 55mAllegiant Air

dom. 12/219:08 amTYS - FSD

1 stop25h 19mAllegiant Air

Deal found 10/23

$379

mié. 11/125:30 amFSD - TYS

1 stop6h 13mAmerican Airlines

dom. 11/235:10 amTYS - FSD

1 stop8h 26mAmerican Airlines

Deal found 10/21

$404

vie. 10/311:30 pmRAP - TYS

1 stop21h 47mUnited Airlines

dom. 11/24:55 pmTYS - RAP

1 stop5h 31mUnited Airlines

Deal found 10/21

$1,305

vie. 10/316:05 amRAP - TYS

2 stops11h 04mDelta

dom. 11/26:04 pmTYS - RAP

1 stop6h 32mDelta

Deal found 10/23

$2,442

Best flights from South Dakota to Knoxville
Discover carefully curated flight deals from South Dakota to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated octubre 23, 2025.

sáb. 11/85:27 pmFSD - TYS

1 stop5h 41mAmerican Airlines

mié. 11/126:16 pmTYS - FSD

1 stop5h 11mAmerican Airlines

Deal found 10/23

$259

mié. 2/251:20 pmFSD - TYS

2 stops7h 12mDelta

sáb. 2/287:30 amTYS - FSD

2 stops9h 03mDelta

Deal found 10/22

$349

mié. 3/45:20 amRAP - TYS

2 stops16h 24mUnited Airlines

sáb. 3/77:00 amTYS - RAP

2 stops15h 33mUnited Airlines

Deal found 10/21

$662

mié. 2/254:26 pmFSD - TYS

1 stop3h 57mAmerican Airlines

sáb. 2/288:13 amTYS - FSD

1 stop7h 37mAmerican Airlines

Deal found 10/21

$371

vie. 3/275:44 pmFSD - TYS

1 stop4h 57mAmerican Airlines

mié. 4/13:00 pmTYS - FSD

1 stop6h 55mAmerican Airlines

Deal found 10/22

$379

mié. 3/44:00 pmRAP - TYS

1 stop5h 00mDelta

sáb. 3/76:45 amTYS - RAP

1 stop17h 29mDelta

Deal found 10/20

$622

Last-minute flights from South Dakota to Knoxville
Discover last-minute flight deals from South Dakota to Knoxville. Data last updated octubre 23, 2025 and is based on user searches.

sáb. 10/255:05 pmFSD - TYS

1 stop6h 18mAmerican Airlines

mar. 10/287:05 amTYS - FSD

1 stop6h 40mAmerican Airlines

Deal found 10/21

$329

vie. 10/311:30 pmRAP - TYS

1 stop21h 47mUnited Airlines

dom. 11/24:55 pmTYS - RAP

1 stop5h 31mUnited Airlines

Deal found 10/21

$1,305

vie. 10/316:05 amRAP - TYS

2 stops11h 04mDelta

dom. 11/26:04 pmTYS - RAP

1 stop6h 32mDelta

Deal found 10/23

$2,442

sáb. 11/85:27 pmFSD - TYS

1 stop5h 41mAmerican Airlines

mié. 11/126:16 pmTYS - FSD

1 stop5h 11mAmerican Airlines

Deal found 10/22

$254

mié. 11/125:30 amFSD - TYS

1 stop6h 13mAmerican Airlines

dom. 11/235:10 amTYS - FSD

1 stop8h 26mAmerican Airlines

Deal found 10/21

$404

mié. 11/1210:59 amFSD - TYS

1 stop5h 47mAmerican Airlines

lun. 11/174:27 pmTYS - FSD

1 stop5h 43mAmerican Airlines

Deal found 10/20

$406

Cheap flight deals from South Dakota to Knoxville

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$254 (American Airlines)
Popular in	January
Cheapest in	September
Average price	$306

Provider with most accurate pricing for Sioux Falls Joe Foss Field-Knoxville McGhee Tyson flight deals.

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Provider most trusted by Cheapflights users for Sioux Falls Joe Foss Field-Knoxville McGhee Tyson flights.

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From South Dakota to Knoxville McGhee Tyson

Search Deals

Highest demand for flights based on searches. 13% potential increase in price ($58 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in October 2025

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Cheapflights Fare Finder

Use the filters below to find and compare flights from South Dakota to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

sáb. 11/8

5:27 pm-12:08 am

1 stop5h 41m

Knoxville McGhee Tyson

mié. 11/12

6:16 pm-10:27 pm

1 stop5h 11m

$259

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

mié. 2/25

1:20 pm-9:32 pm

2 stops7h 12m

Knoxville McGhee Tyson

sáb. 2/28

7:30 am-3:33 pm

2 stops9h 03m

$349

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

mié. 2/25

4:26 pm-9:23 pm

1 stop3h 57m

Knoxville McGhee Tyson

sáb. 2/28

8:13 am-2:50 pm

1 stop7h 37m

$371

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

vie. 3/27

5:44 pm-11:41 pm

1 stop4h 57m

Knoxville McGhee Tyson

mié. 4/1

3:00 pm-8:55 pm

1 stop6h 55m

$379

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

mié. 3/4

4:00 pm-11:00 pm

1 stop5h 00m

Knoxville McGhee Tyson

sáb. 3/7

6:45 am-10:14 pm

1 stop17h 29m

$622

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

mié. 3/4

5:20 am-11:44 pm

2 stops16h 24m

Knoxville McGhee Tyson

sáb. 3/7

7:00 am-8:33 pm

2 stops15h 33m

$662

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/23

Best time to book a flight from South Dakota to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Dakota with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Dakota to Knoxville

What is the cheapest month to book a flight from South Dakota to Knoxville?

Currently, July is the cheapest month in which you can book a flight from South Dakota to Knoxville (average of $248). Flying from South Dakota to Knoxville in January is currently the most expensive (average of $387). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SD to TYS?

It’s optimal to fly from South Dakota to Knoxville at noon. By choosing this option you can save up to 45% on the cost of your flight, compared to a flight in the afternoon.

How much does it cost to fly round-trip from South Dakota to Knoxville?

Related info for your journey

What airport do you fly into for flights to Knoxville from South Dakota?
Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from South Dakota.
How long is the flight from South Dakota to Knoxville?
American Airlines and Delta can get you from South Dakota to Knoxville in just under 5h 41m. Your travel time can differ by up to 1h 31m. The distance between South Dakota and Knoxville is about 863 mi. This flight may include one or multiple stops.
Can I find deals for flights from South Dakota to Knoxville that include hotel bookings?
Yes. In addition to deals on South Dakota to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from South Dakota to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Dakota to Knoxville.
Can I find deals for business class flights from South Dakota to Knoxville?
Yes. Cheapflights offers flight deals from South Dakota to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from South Dakota to Knoxville?
Currently, July is the cheapest month in which you can book a flight from South Dakota to Knoxville (average of $248). Flying from South Dakota to Knoxville in January is currently the most expensive (average of $387). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Morristown

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Crossville

Corbin

Bryson City

Alcoa

Oak Ridge

Murphy

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Top 3 airlines flying from South Dakota to Knoxville

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$248	Average$409	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$248	Average$323	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$268	Average$443	FlexibilityNo cancel fee	On-time69%

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$254+ Cheap flights from South Dakota to Knoxville (TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/8. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from South Dakota to Knoxville with Cheapflights

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2. Select your favorite providers

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Find flight deals from South Dakota to Knoxville

Cheapest flights from South Dakota to KnoxvilleExplore the most affordable flight options available from South Dakota to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 23, 2025.

Explore the most affordable flight options available from South Dakota to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 23, 2025.

Cheap flight deals from South Dakota to Knoxville

Keep the following information in mind while searching for South Dakota to Knoxville flight deals. Data was last updated octubre 23, 2025.

Most accurate provider

Most trusted provider

Round-trip from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Dakota to Knoxville that are best for you.

Best time to book a flight from South Dakota to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Dakota with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from South Dakota to Knoxville

What is the cheapest month to book a flight from South Dakota to Knoxville?

What is the cheapest time of day to fly from SD to TYS?

Find hourly flight availability from South Dakota to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 23, 2025.

How much does it cost to fly round-trip from South Dakota to Knoxville?

Related info for your journey

Find useful and relevant information for your journey from South Dakota to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Knoxville from South Dakota?

How long is the flight from South Dakota to Knoxville?

Can I find deals for flights from South Dakota to Knoxville that include hotel bookings?

How can I find direct flights from South Dakota to Knoxville?

Can I find deals for business class flights from South Dakota to Knoxville?

What is the cheapest month to book a flight from South Dakota to Knoxville?

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Alternative routes for South Dakota to Knoxville

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Top 3 airlines flying from South Dakota to Knoxville

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Cheapest flights from South Dakota to Knoxville
Explore the most affordable flight options available from South Dakota to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 23, 2025.