HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$263+ Cheap flights from Roanoke to Knoxville (ROA - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — TYS
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Roanoke to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Roanoke to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Roanoke (ROA) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$263
(Delta)
From Roanoke to Knoxville McGhee Tyson
Search Deals

Find flight deals from Roanoke to Knoxville

Cheapest flights from Roanoke to Knoxville
Explore the most affordable flight options available from Roanoke to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/28:09 pmROA - TYS
1 stop3h 58mAmerican Airlines
Mon 10/68:37 pmTYS - ROA
1 stop3h 22mAmerican Airlines
Deal found 9/17$284
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/210:30 amROA - TYS
1 stop4h 15mUnited Airlines
Mon 10/67:00 amTYS - ROA
2 stops7h 04mUnited Airlines
Deal found 9/17$407
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/17:03 pmROA - TYS
1 stop4h 00mAmerican Airlines
Sun 10/58:31 pmTYS - ROA
1 stop3h 40mAmerican Airlines
Deal found 9/16$437
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/243:00 pmROA - TYS
1 stop19h 29mUnited Airlines
Mon 10/277:20 pmTYS - ROA
1 stop4h 10mUnited Airlines
Deal found 9/17$442
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/13:00 pmROA - TYS
1 stop6h 11mUnited Airlines
Sun 10/57:00 amTYS - ROA
1 stop27h 17mUnited Airlines
Deal found 9/16$443

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Roanoke to Knoxville that are best for you.

Fly from

Roanoke

Fly to

Knoxville

Route

Depart

Return

Price

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Sat 2/21

7:50 pm-11:44 pm

1 stop3h 54m

Knoxville McGhee Tyson

Tue 2/24

10:05 am-2:39 pm

1 stop4h 34m

$263

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Sat 2/21

5:22 am-8:27 am

1 stop3h 05m

Knoxville McGhee Tyson

Tue 2/24

9:09 am-12:20 pm

1 stop3h 11m

$279

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Thu 10/2

8:09 pm-12:07 am

1 stop3h 58m

Knoxville McGhee Tyson

Mon 10/6

8:37 pm-11:59 pm

1 stop3h 22m

$284

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Thu 10/2

10:30 am-2:45 pm

1 stop4h 15m

Knoxville McGhee Tyson

Mon 10/6

7:00 am-2:04 pm

2 stops7h 04m

$407

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Wed 10/1

7:03 pm-11:03 pm

1 stop4h 00m

Knoxville McGhee Tyson

Sun 10/5

8:31 pm-12:11 am

1 stop3h 40m

$437

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Fri 10/24

3:00 pm-10:29 am

1 stop19h 29m

Knoxville McGhee Tyson

Mon 10/27

7:20 pm-11:30 pm

1 stop4h 10m

$442

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Wed 10/1

3:00 pm-9:11 pm

1 stop6h 11m

Knoxville McGhee Tyson

Sun 10/5

7:00 am-10:17 am

1 stop27h 17m

$443

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Best time to book a flight from Roanoke to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 17, 2025.
Read reviews from past customers who have flown American Airlines from Roanoke to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Crew

8.0

Food

6.4

Overall

7.2

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Crew

8.0

Food

6.4

Overall

7.2

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Roanoke to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Roanoke to Knoxville?

    Departing from Roanoke to Knoxville will take you 3h 05m. Airlines will cover a distance of 246 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Roanoke to Knoxville that include hotel bookings?

    Yes. In addition to deals on Roanoke to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to Knoxville.

  • Can I find deals for business class flights from Roanoke to Knoxville?

    Yes. Cheapflights offers flight deals from Roanoke to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Roanoke to Knoxville (average of $295). Flying from Roanoke to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Roanoke to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Reagan-National to Nashville flights
Dulles Intl to Nashville flights
Raleigh to Nashville flights
Reagan-National to Knoxville flights
Dulles Intl to Memphis flights
Dulles Intl to Knoxville flights
Reagan-National to Memphis flights
Richmond to Nashville flights
Roanoke to Nashville flights
Norfolk to Nashville flights
Reagan-National to Chattanooga flights
Dulles Intl to Chattanooga flights
Norfolk to Memphis flights
Greensboro to Nashville flights
Richmond to Memphis flights
Charlottesville to Nashville flights
Raleigh to Memphis flights
Greensboro to Memphis flights
Raleigh to Knoxville flights
Richmond to Chattanooga flights
Raleigh to Chattanooga flights
Richmond to Knoxville flights
Norfolk to Knoxville flights
Roanoke to Memphis flights
Blountville to Memphis flights
Charlottesville to Memphis flights
Dulles Intl to Blountville flights
Raleigh to Blountville flights
Greensboro to Chattanooga flights
Norfolk to Chattanooga flights
Reagan-National to Blountville flights
Newport News to Nashville flights
Lynchburg to Nashville flights
Blountville to Nashville flights
Roanoke to Chattanooga flights
Newport News to Memphis flights
Newport News to Chattanooga flights
Staunton to Nashville flights
Blountville to Knoxville flights
Newport News to Blountville flights
Lewisburg to Nashville flights

Top airline flying from Roanoke to Knoxville

Discover the top airline that operate flights from Roanoke to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$139Average$488FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2025 Cheapflights