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$109+ Cheap flights from New Orleans to Knoxville (MSY - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/22. Fares are subject to change and may not be available on all flights or dates of travel.
MSY — TYS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from New Orleans Louis Armstrong to Knoxville McGhee Tyson are usually found in July or January, booked 70 days in advance, depart on a Wednesday or Tuesday and return on a Saturday

Cheap flight deals from New Orleans to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from New Orleans (MSY) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$217
(United Airlines)

One-way from

$109
(Delta)

Popular in

December

Cheapest in

July

Average price

$307
From New Orleans Louis Armstrong to Knoxville McGhee Tyson
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One-way flight from New Orleans Louis Armstrong to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 4% potential increase in price ($15 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from New Orleans to Knoxville

Cheapest flights from New Orleans to Knoxville
Explore the most affordable flight options available from New Orleans to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/83:58 pmMSY - TYS
1 stop5h 52mUnited Airlines
Wed 10/155:53 pmTYS - MSY
1 stop5h 28mUnited Airlines
Deal found 9/10$217
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/177:28 pmMSY - TYS
1 stop11h 22mMultiple Airlines
Mon 10/206:00 amTYS - MSY
1 stop15h 34mMultiple Airlines
Deal found 9/11$237
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2011:12 amMSY - TYS
1 stop10h 14mMultiple Airlines
Sun 11/235:49 pmTYS - MSY
1 stop19h 06mMultiple Airlines
Deal found 9/11$250
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1611:02 amMSY - TYS
1 stop4h 42mMultiple Airlines
Mon 10/206:00 amTYS - MSY
1 stop15h 34mMultiple Airlines
Deal found 9/11$255
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/17:45 amMSY - TYS
1 stop4h 57mDelta
Sun 11/98:05 pmTYS - MSY
1 stop4h 30mDelta
Deal found 9/10$262
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:39 pmMSY - TYS
1 stop4h 12mAmerican Airlines
Sun 11/236:30 amTYS - MSY
1 stop6h 43mAmerican Airlines
Deal found 9/10$269
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/29:10 amMSY - TYS
1 stop10h 15mMultiple Airlines
Sun 10/57:20 amTYS - MSY
1 stop27h 55mMultiple Airlines
Deal found 9/11$271
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/217:00 amMSY - TYS
1 stop5h 17mUnited Airlines
Mon 11/245:52 pmTYS - MSY
1 stop5h 34mUnited Airlines
Deal found 9/10$273
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/259:10 amMSY - TYS
1 stop6h 55mMultiple Airlines
Mon 9/291:22 pmTYS - MSY
1 stop19h 33mMultiple Airlines
Deal found 9/10$278
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/276:34 amMSY - TYS
1 stop6h 09mAmerican Airlines
Mon 9/296:00 amTYS - MSY
1 stop5h 04mAmerican Airlines
Deal found 9/10$279
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/268:19 pmMSY - TYS
1 stop12h 59mMultiple Airlines
Sun 9/283:19 pmTYS - MSY
2 stops30h 12mMultiple Airlines
Deal found 9/11$283

Cheapflights Fare Finder

 
Customize your flight search to find flights from New Orleans to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from New Orleans to Knoxville that are best for you.

Fly from

New Orleans

Fly to

Knoxville

Route

Depart

Return

Price

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 2/21

7:10 pm-11:44 pm

1 stop3h 34m

Knoxville McGhee Tyson

Tue 2/24

7:20 pm-11:27 pm

1 stop5h 07m

$217

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Wed 10/8

3:58 pm-10:50 pm

1 stop5h 52m

Knoxville McGhee Tyson

Wed 10/15

5:53 pm-10:21 pm

1 stop5h 28m

$217

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 10/17

7:28 pm-7:50 am

1 stop11h 22m

Knoxville McGhee Tyson

Mon 10/20

6:00 am-8:34 pm

1 stop15h 34m

$237

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 10/16

11:02 am-4:44 pm

1 stop4h 42m

Knoxville McGhee Tyson

Mon 10/20

6:00 am-8:34 pm

1 stop15h 34m

$255

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 11/1

7:45 am-1:42 pm

1 stop4h 57m

Knoxville McGhee Tyson

Sun 11/9

8:05 pm-11:35 pm

1 stop4h 30m

$262

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 2/12

7:23 am-3:23 pm

1 stop7h 00m

Knoxville McGhee Tyson

Sun 2/15

4:33 pm-10:07 pm

1 stop6h 34m

$269

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 11/20

3:29 pm-10:54 pm

1 stop6h 25m

Knoxville McGhee Tyson

Sun 11/23

6:18 pm-10:51 pm

1 stop5h 33m

$269

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 11/21

7:00 am-1:17 pm

1 stop5h 17m

Knoxville McGhee Tyson

Mon 11/24

5:52 pm-10:26 pm

1 stop5h 34m

$273

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 9/27

6:34 am-1:43 pm

1 stop6h 09m

Knoxville McGhee Tyson

Mon 9/29

6:00 am-10:04 am

1 stop5h 04m

$279

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 9/26

8:19 pm-10:18 am

1 stop12h 59m

Knoxville McGhee Tyson

Sun 9/28

3:19 pm-8:31 pm

2 stops30h 12m

$283

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 19 results
1
2

Best time to book a flight from New Orleans to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from New Orleans with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from New Orleans to Knoxville

How far ahead should I book a flight from New Orleans to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from New Orleans to Knoxville. Price data was last updated on August 29, 2025.

To ensure you get the cheapest price possible for a flight from New Orleans to Knoxville, you should look to book at least 52 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from New Orleans to Knoxville?

Currently, January is the cheapest month in which you can book a flight from New Orleans to Knoxville (average of $294). Flying from New Orleans to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MSY to TYS?

Find hourly flight availability from New Orleans to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

One of the essential ways to save on airfare from New Orleans to Knoxville is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 13% on airfare.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 11, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from New Orleans to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Food

7.3

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from New Orleans to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from New Orleans to Knoxville?

    For as low as $217, Delta can have you in Knoxville from New Orleans in 3h 34m. New Orleans and Knoxville are separated by a distance of 541 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from New Orleans to Knoxville round-trip?

    According to our current data, United Airlines ($198), American Airlines ($248), and Delta ($248) offers the cheapest pricing from New Orleans to Knoxville. You may be able to fly from New Orleans to Knoxville for 40% less than the average price by searching for these airlines.

  • Can I find deals for flights from New Orleans to Knoxville that include hotel bookings?

    Yes. In addition to deals on New Orleans to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from New Orleans to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from New Orleans to Knoxville.

  • Can I find deals for business class flights from New Orleans to Knoxville?

    Yes. Cheapflights offers flight deals from New Orleans to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from New Orleans to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from New Orleans to Knoxville (average of $294). Flying from New Orleans to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from New Orleans to Knoxville

Discover the top 3 airlines that operate flights from New Orleans to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$400FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$338FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$336FlexibilityNo cancel feeOn-timeN/A

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