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$109+ Cheap flights from Key Largo, FL to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — TYS
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to Knoxville McGhee Tyson are usually found in July or October, booked 62 days in advance, depart on a Tuesday or Wednesday and return on a Saturday

Cheap flight deals from Key Largo to Knoxville

Keep the following information in mind while searching for Key Largo to Knoxville flight deals. Data was last updated September 16, 2025.

Round-trip from

$163
(American Airlines)

One-way from

$109
(Kiwi.com)

Popular in

March

Cheapest in

July

Average price

$430
From Key Largo to Knoxville McGhee Tyson
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One-way flight from Key Largo to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 1% potential increase in price ($4 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Key Largo to Knoxville

Cheapest flights from Key Largo to Knoxville
Explore the most affordable flight options available from Key Largo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/112:21 pmMIA - TYS
Nonstop2h 16mAmerican Airlines
Tue 11/185:07 pmTYS - MIA
Nonstop2h 12mAmerican Airlines
Deal found 9/13$163
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/69:40 pmMIA - TYS
Nonstop2h 19mAmerican Airlines
Mon 11/105:07 pmTYS - MIA
Nonstop2h 12mAmerican Airlines
Deal found 9/15$165
This Frontier deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/96:00 amMIA - TYS
1 stop12h 22mFrontier
Thu 11/137:17 pmTYS - MIA
1 stop11h 02mFrontier
Deal found 9/14$182
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/68:11 amMIA - TYS
1 stop6h 40mDelta
Mon 11/103:51 pmTYS - MIA
1 stop4h 55mDelta
Deal found 9/14$183
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/177:37 pmMIA - TYS
1 stop4h 09mDelta
Tue 10/216:12 amTYS - MIA
1 stop7h 51mDelta
Deal found 9/15$221
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/39:35 pmMIA - TYS
Nonstop2h 15mAmerican Airlines
Mon 10/68:37 pmTYS - MIA
1 stop3h 52mAmerican Airlines
Deal found 9/15$243
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/65:56 pmMIA - TYS
2 stops28h 30mMultiple Airlines
Mon 11/107:20 amTYS - MIA
1 stop25h 50mMultiple Airlines
Deal found 9/15$248
This Frontier deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:00 amMIA - TYS
1 stop12h 22mFrontier
Sun 11/167:17 pmTYS - MIA
1 stop11h 02mFrontier
Deal found 9/15$252
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/177:10 amMIA - TYS
1 stop6h 32mDelta
Mon 10/208:10 pmTYS - MIA
1 stop4h 19mDelta
Deal found 9/16$259

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Key Largo to Knoxville that are best for you.

Fly from

Key Largo

Fly to

Knoxville

Route

Depart

Return

Price

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 11/6

8:11 am-2:51 pm

1 stop6h 40m

Knoxville McGhee Tyson

Mon 11/10

3:51 pm-8:46 pm

1 stop4h 55m

$183

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 12/5

8:05 am-2:51 pm

1 stop6h 46m

Knoxville McGhee Tyson

Mon 12/8

7:59 pm-12:46 am

1 stop4h 47m

$221

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 10/4

9:35 pm-11:50 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Sat 10/11

4:18 pm-11:32 pm

1 stop7h 14m

$243

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 11/12

8:05 am-2:46 pm

1 stop6h 41m

Knoxville McGhee Tyson

Sat 11/15

3:51 pm-8:46 pm

1 stop4h 55m

$261

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 10/8

7:23 pm-12:28 pm

1 stop17h 05m

Knoxville McGhee Tyson

Thu 10/16

4:23 pm-11:42 pm

1 stop7h 19m

$295

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 10/24

9:24 pm-11:39 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Tue 10/28

6:15 am-8:22 am

Nonstop2h 07m

$298

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Tue 9/23

6:00 am-9:44 am

1 stop3h 44m

Knoxville McGhee Tyson

Tue 9/30

5:45 am-11:01 am

1 stop5h 16m

$303

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 12/5

2:14 pm-4:33 pm

Nonstop2h 19m

Knoxville McGhee Tyson

Sun 12/7

5:05 am-9:16 am

1 stop4h 11m

$308

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 10/24

11:34 am-10:13 pm

1 stop10h 39m

Knoxville McGhee Tyson

Tue 10/28

11:23 am-6:11 pm

2 stops30h 48m

$313

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 10/23

7:39 pm-11:46 pm

1 stop4h 07m

Knoxville McGhee Tyson

Tue 10/28

5:16 pm-8:51 pm

1 stop3h 35m

$318

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 21 results
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Best time to book a flight from Key Largo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Knoxville

How far ahead should I book a flight from Key Largo to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Knoxville. Price data was last updated on September 12, 2025.

Booking 62 days in advance of your planned departure date is, on average, the best time to get cheap flights from Key Largo to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Key Largo to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Key Largo to Knoxville (average of $295). Flying from Key Largo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to TYS?

Find hourly flight availability from Key Largo to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

When flying from Key Largo to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Key Largo to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to Knoxville flight should consider departing on Sunday mornings when fares are most often at their lowest. Monday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to Knoxville

Explore weekly flight availability from Key Largo to Knoxville. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 16, 2025.

The most flights from KE9 to TYS are scheduled on a Monday (2 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 16, 2025.
Read through reviews of airlines operating flights from Key Largo to Knoxville, such as Delta, American Airlines, and Allegiant Air. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Boarding

8.2

Overall

8.0

Crew

8.5

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Boarding

8.2

Overall

8.0

Crew

8.5

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Boarding

8.2

Overall

8.0

Crew

8.5

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Allegiant Air
7.2
Good
699 reviews
Delta
8.0
Very good
7,957 reviews

Boarding

8.2

Overall

8.0

Crew

8.5

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Key Largo?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Key Largo. On average, McGhee Tyson has 2 inbound flights from Key Largo per day from 3 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Key Largo to Knoxville?

    Airlines like Delta and American Airlines fly from Key Largo to Knoxville in about 2h 15m. The time it takes to get you to your destination can typically vary by up to 4h 25m. The distance from Key Largo to Knoxville is about 725 mi. This flight may include one or multiple stops.

  • What are the most reliable airlines from Key Largo to Knoxville?

    Consider Envoy Air (85%), American Airlines (51%) or Republic Airways (33%) when booking your flight. These represent the most reliable airlines when flying from Key Largo to Knoxville.

  • What are the cheapest flights from Key Largo to Knoxville?

    The cheapest flight price from Key Largo to Knoxville is $159. On average you can expect to pay $273. The most popular route, (Miami - Knoxville McGhee Tyson), can usually be booked for $183.

  • Can I find deals for flights from Key Largo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Key Largo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Knoxville.

  • Can I find deals for business class flights from Key Largo to Knoxville?

    Yes. Cheapflights offers flight deals from Key Largo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Key Largo to Knoxville (average of $295). Flying from Key Largo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Key Largo to Knoxville

Discover the top 3 airlines that operate flights from Key Largo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$91Average$192FlexibilityNo cancel feeOn-time88%
DeltaCheapest$188Average$341FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$192Average$380FlexibilityNo cancel feeOn-time71%

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