HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$91+ Cheap flights from Key Largo, FL to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — TYS
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Key Largo to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Key Largo to Knoxville McGhee Tyson are usually found in July or October, booked 36 days in advance, depart on a Tuesday or Wednesday and return on a Monday

Cheap flight deals from Key Largo to Knoxville

Keep the following information in mind while searching for Key Largo to Knoxville flight deals. Data was last updated June 12, 2025.

Round-trip from

$159
(American Airlines)

One-way from

$91
(Mytrip)

Popular in

March

Cheapest in

July

Average price

$331
From Key Largo to Knoxville McGhee Tyson
Search Deals
One-way flight from Key Largo to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($10 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2025
Search Deals

Find flight deals from Key Largo to Knoxville

Cheapest flights from Key Largo to Knoxville
Explore the most affordable flight options available from Key Largo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1010:05 pmMIA - TYS
Nonstop1h 54mAmerican Airlines
Mon 7/146:05 amTYS - MIA
Nonstop2h 10mAmerican Airlines
Deal found 6/10$159
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/107:23 pmMIA - TYS
1 stop4h 36mDelta
Mon 7/147:43 pmTYS - MIA
1 stop5h 12mDelta
Deal found 6/11$189
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1012:46 pmMIA - TYS
1 stop28h 01mMultiple Airlines
Fri 7/255:02 pmTYS - MIA
1 stop27h 02mMultiple Airlines
Deal found 6/10$197
This Frontier deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/126:00 amMIA - TYS
1 stop10h 29mFrontier
Sun 6/155:25 pmTYS - MIA
1 stop13h 05mFrontier
Deal found 6/12$435
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1612:06 pmMIA - TYS
1 stop7h 55mUnited Airlines
Tue 8/197:00 amTYS - MIA
2 stops28h 20mUnited Airlines
Deal found 6/12$446

Cheapflights Fare Finder

Customize your flight search to find flights from Key Largo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Key Largo to Knoxville that are best for you.

Fly from

Key Largo

Fly to

Knoxville

Route

Depart

Return

Price

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 7/11

10:05 pm-11:59 pm

Nonstop1h 54m

Knoxville McGhee Tyson

Mon 7/14

6:05 am-8:15 am

Nonstop2h 10m

$159

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 7/9

5:30 am-11:08 am

1 stop5h 38m

Knoxville McGhee Tyson

Wed 7/16

5:30 am-9:28 am

1 stop3h 58m

$189

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 7/10

12:46 pm-4:47 pm

1 stop28h 01m

Knoxville McGhee Tyson

Fri 7/25

5:02 pm-8:04 pm

1 stop27h 02m

$197

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 7/10

7:45 am-8:57 pm

2 stops13h 12m

Knoxville McGhee Tyson

Fri 7/25

7:00 am-3:10 pm

1 stop8h 10m

$458

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 6/26

6:00 am-4:29 pm

1 stop10h 29m

Knoxville McGhee Tyson

Sun 6/29

5:25 pm-11:28 am

2 stops18h 03m

$542

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 7/10

11:11 am-4:12 pm

2 stops29h 01m

$140

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 7/9

6:55 am-11:08 am

1 stop4h 13m

$179

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sun 6/15

6:00 am-4:29 pm

1 stop10h 29m

$183

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 7/3

1:35 pm-2:58 pm

1 stop25h 23m

$245

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 7/9

10:05 pm-11:59 pm

Nonstop1h 54m

$305

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Best time to book a flight from Key Largo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Knoxville

How far ahead should I book a flight from Key Largo to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Knoxville. Price data was last updated on June 9, 2025.

Booking 36 days in advance of your planned departure date is, on average, the best time to get cheap flights from Key Largo to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Key Largo to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Key Largo to Knoxville (average of $296). Flying from Key Largo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to TYS?

Find hourly flight availability from Key Largo to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

When flying from Key Largo to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Key Largo to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to Knoxville flight should consider departing on Sunday mornings when fares are most often at their lowest. Monday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated June 12, 2025.
See what other customers who have flown with Delta, United Airlines and American Airlines from Key Largo to Knoxville have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,946 reviews

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,946 reviews
Delta
8.0
Very good
7,946 reviews

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,946 reviews

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,946 reviews

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Frontier
6.0
Okay
3,295 reviews
Delta
8.0
Very good
7,946 reviews

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Key Largo?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Key Largo. On average, McGhee Tyson has 0 inbound flights from Key Largo per day from 3 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • What are the cheapest airlines to fly from Key Largo to Knoxville one-way?

    $167 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $179 and $245, respectively.

  • What are the most reliable airlines from Key Largo to Knoxville?

    Consider Qatar Airways (53%), American Airlines (39%) or Envoy Air (36%) when booking your flight. These represent the most reliable airlines when flying from Key Largo to Knoxville.

  • What are the cheapest flights from Key Largo to Knoxville?

    The cheapest flight price from Key Largo to Knoxville is $159. On average you can expect to pay $315. The most popular route, (Miami - Knoxville McGhee Tyson), can usually be booked for $179.

  • Can I find deals for flights from Key Largo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Key Largo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Knoxville.

  • Can I find deals for business class flights from Key Largo to Knoxville?

    Yes. Cheapflights offers flight deals from Key Largo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Key Largo to Knoxville (average of $296). Flying from Key Largo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Key Largo?

Book flights to Key Largo if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Key Largo to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Fort Lauderdale to Nashville flights
Orlando to Nashville flights
Tampa to Nashville flights
Miami to Nashville flights
West Palm Beach to Nashville flights
Fort Myers to Nashville flights
Jacksonville to Nashville flights
Fort Lauderdale to Knoxville flights
Orlando to Memphis flights
Sarasota to Nashville flights
Miami to Knoxville flights
Tampa to Knoxville flights
Tampa to Chattanooga flights
Panama City to Nashville flights
West Palm Beach to Knoxville flights
St Petersburg to Knoxville flights
Orlando to Knoxville flights
Orlando Sanford Intl to Knoxville flights
Tampa to Memphis flights
Pensacola to Nashville flights
Miami to Memphis flights
Fort Myers to Knoxville flights
Fort Lauderdale to Memphis flights
Jacksonville to Memphis flights
Punta Gorda to Nashville flights
Jacksonville to Knoxville flights
Valparaiso to Nashville flights
Miami to Chattanooga flights
Sarasota to Knoxville flights
Fort Myers to Chattanooga flights
Gainesville to Nashville flights
Pensacola to Memphis flights
Pensacola to Knoxville flights
West Palm Beach to Memphis flights
Fort Lauderdale to Chattanooga flights
Tallahassee to Nashville flights
Key West to Nashville flights
Fort Myers to Memphis flights
Sarasota to Chattanooga flights
Jacksonville to Blountville flights
Tampa to Blountville flights
Melbourne to Nashville flights
Daytona Beach to Nashville flights
Orlando to Chattanooga flights
Panama City to Knoxville flights
Orlando to Blountville flights
Sarasota to Memphis flights
West Palm Beach to Blountville flights
Sarasota to Blountville flights
Tallahassee to Knoxville flights

Top 3 airlines flying from Key Largo to Knoxville

Discover the top 3 airlines that operate flights from Key Largo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$91Average$184FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$183Average$379FlexibilityNo cancel feeOn-time71%
DeltaCheapest$191Average$318FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.