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$82+ Cheap flights from Key Largo, FL to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/15. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — TYS
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to Knoxville McGhee Tyson are usually found in July or February, booked 32 days in advance, depart on a Wednesday or Thursday and return on a Friday

Cheap flight deals from Key Largo to Knoxville

Cheapest flights from Key Largo to Knoxville
Explore the most affordable flight options available from Key Largo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:30 amMIA - TYS
1 stop11h 07mMultiple Airlines
Wed 12/3112:01 pmTYS - MIA
2 stops33h 03mMultiple Airlines
Deal found 12/16$288
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:30 amMIA - TYS
2 stops10h 45mMultiple Airlines
Sat 1/37:15 amTYS - MIA
1 stop26h 20mMultiple Airlines
Deal found 12/16$325
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/309:59 pmMIA - TYS
2 stops18h 16mMultiple Airlines
Fri 1/27:15 amTYS - MIA
1 stop10h 39mMultiple Airlines
Deal found 12/16$365
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:30 amMIA - TYS
1 stop11h 07mMultiple Airlines
Fri 1/26:00 amTYS - MIA
2 stops31h 06mMultiple Airlines
Deal found 12/17$385
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/162:14 pmMIA - TYS
Nonstop2h 19mAmerican Airlines
Tue 12/237:01 pmTYS - MIA
Nonstop2h 12mAmerican Airlines
Deal found 12/15$455
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:30 amMIA - TYS
2 stops26h 48mMultiple Airlines
Fri 1/27:15 amTYS - MIA
1 stop10h 39mMultiple Airlines
Deal found 12/17$464
This Orbitz deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:05 amMIA - TYS
1 stop9h 26mFrontier
Mon 12/224:46 pmTYS - MIA
1 stop12h 14mFrontier
Deal found 12/16$472
This Delta deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1612:36 pmMIA - TYS
1 stop6h 22mDelta
Tue 12/2310:02 amTYS - MIA
1 stop5h 52mDelta
Deal found 12/15$475

Find flight deals from Key Largo to Knoxville

Keep the following information in mind while searching for Key Largo to Knoxville flight deals. Data was last updated December 18, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$153
(Kiwi.com)

One-way from

$82
(Kiwi.com)

Popular in

September

Cheapest in

July

Average price

$429
Provider with most accurate pricing for Miami-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Miami-Knoxville McGhee Tyson flights.
Search Deals
From Key Largo to Knoxville McGhee Tyson
Search Deals
One-way flight from Key Largo to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($104 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($29 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Key Largo to Knoxville that are best for you.

Fly from

Key Largo

Fly to

Knoxville

Route

Depart

Return

Price

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 2/6

2:37 pm-5:06 pm

Nonstop2h 29m

Knoxville McGhee Tyson

Sun 2/8

6:20 am-8:38 am

Nonstop2h 18m

$180

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 1/28

2:57 pm-8:39 am

2 stops17h 42m

Knoxville McGhee Tyson

Sun 2/1

1:39 pm-6:50 pm

1 stop29h 11m

$197

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 1/8

6:20 pm-11:45 pm

1 stop5h 25m

Knoxville McGhee Tyson

Mon 1/12

6:09 pm-10:48 pm

1 stop4h 39m

$219

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 1/8

6:20 pm-11:45 pm

1 stop5h 25m

Knoxville McGhee Tyson

Tue 1/13

5:40 am-12:14 pm

1 stop6h 34m

$219

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 1/8

6:20 pm-11:45 pm

1 stop5h 25m

Knoxville McGhee Tyson

Sun 1/11

5:40 am-10:40 am

1 stop5h 00m

$219

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 2/19

9:33 pm-11:55 pm

Nonstop2h 22m

Knoxville McGhee Tyson

Mon 2/23

2:50 pm-8:55 pm

1 stop6h 05m

$234

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 2/18

6:00 am-11:08 am

1 stop5h 08m

Knoxville McGhee Tyson

Sat 2/21

5:30 am-9:26 am

1 stop3h 56m

$239

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 1/28

8:15 am-1:50 pm

1 stop5h 35m

Knoxville McGhee Tyson

Sun 2/1

2:37 pm-8:44 pm

1 stop6h 07m

$249

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 1/14

10:29 am-3:19 pm

1 stop4h 50m

Knoxville McGhee Tyson

Tue 1/20

5:40 am-9:24 am

1 stop3h 44m

$249

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 2/19

7:05 am-10:10 pm

2 stops15h 05m

$110

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 20 results
1
2

Best time to book a flight from Key Largo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Knoxville

How far ahead should I book a flight from Key Largo to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Knoxville. Price data was last updated on December 12, 2025.

Booking 32 days in advance of your planned departure date is, on average, the best time to get cheap flights from Key Largo to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Key Largo to Knoxville?

Currently, April is the cheapest month in which you can book a flight from Key Largo to Knoxville (average of $62). Flying from Key Largo to Knoxville in March is currently the most expensive (average of $97). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to TYS?

Find hourly flight availability from Key Largo to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

When flying from Key Largo to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 39% versus a flight in the evening.

What is the cheapest day to fly from Key Largo to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Knoxville. Price data was last updated on December 13, 2025.

Travelers seeking maximum savings on their Key Largo to Knoxville flight should consider departing on Tuesday at noon when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 18, 2025.
Read through reviews of airlines operating flights from Key Largo to Knoxville, such as Delta, American Airlines, and Allegiant Air. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,055 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Allegiant Air
7.2
Good
700 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Key Largo?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Key Largo. On average, McGhee Tyson has 1 inbound flight from Key Largo per day from 3 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Key Largo to Knoxville?

    Airlines like American Airlines and Delta fly from Key Largo to Knoxville in about 2h 29m. The time it takes to get you to your destination can typically vary by up to 2h 56m. The distance from Key Largo to Knoxville is about 725 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Key Largo to Knoxville one-way?

    $57 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $89 and $149, respectively.

  • What are the most reliable airlines from Key Largo to Knoxville?

    Consider Envoy Air (76%), Finnair (75%) or Qatar Airways (70%) when booking your flight. These represent the most reliable airlines when flying from Key Largo to Knoxville.

  • What are the cheapest flights from Key Largo to Knoxville?

    The cheapest flight price from Key Largo to Knoxville is $179. On average you can expect to pay $428. The most popular route, (Miami - Knoxville McGhee Tyson), can usually be booked for $153.

  • Can I find deals for flights from Key Largo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Key Largo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Knoxville.

  • Can I find deals for business class flights from Key Largo to Knoxville?

    Yes. Cheapflights offers flight deals from Key Largo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Knoxville?

    Currently, April is the cheapest month in which you can book a flight from Key Largo to Knoxville (average of $62). Flying from Key Largo to Knoxville in March is currently the most expensive (average of $97). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Key Largo to Knoxville

Discover the top 3 airlines that operate flights from Key Largo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$92Average$185FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$179Average$380FlexibilityNo cancel feeOn-time71%
DeltaCheapest$182Average$425FlexibilityNo cancel feeOn-timeN/A

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