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$75+ Cheap flights from Key Largo, FL to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/4. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — TYS
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to Knoxville McGhee Tyson are usually found in July or February, booked 62 days in advance, depart on a Tuesday or Thursday and return on a Friday

Cheap flight deals from Key Largo to Knoxville

Keep the following information in mind while searching for Key Largo to Knoxville flight deals. Data was last updated October 30, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$159
(American Airlines)

One-way from

$75
(Priceline)

Popular in

September

Cheapest in

July

Average price

$370
Provider with most accurate pricing for Miami-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Miami-Knoxville McGhee Tyson flights.
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From Key Largo to Knoxville McGhee Tyson
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One-way flight from Key Largo to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 21% potential increase in price ($101 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($30 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Key Largo to Knoxville

Cheapest flights from Key Largo to Knoxville
Explore the most affordable flight options available from Key Largo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/49:34 pmMIA - TYS
Nonstop2h 23mAmerican Airlines
Sun 12/75:03 pmTYS - MIA
Nonstop2h 17mAmerican Airlines
Deal found 10/28$159
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:05 amMIA - TYS
1 stop12h 09mMultiple Airlines
Sun 12/145:23 pmTYS - MIA
1 stop25h 22mMultiple Airlines
Deal found 10/30$173
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/910:32 amMIA - TYS
1 stop4h 20mDelta
Mon 12/157:59 pmTYS - MIA
1 stop4h 47mDelta
Deal found 10/30$179
This Frontier deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/96:00 amMIA - TYS
1 stop12h 22mFrontier
Thu 11/137:17 pmTYS - MIA
1 stop11h 02mFrontier
Deal found 10/29$183
This Frontier deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:00 amMIA - TYS
1 stop9h 57mFrontier
Mon 12/154:52 pmTYS - MIA
1 stop12h 27mFrontier
Deal found 10/30$190
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2011:55 amMIA - TYS
2 stops10h 08mMultiple Airlines
Sun 11/235:49 pmTYS - MIA
1 stop21h 41mMultiple Airlines
Deal found 10/29$191
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/181:02 pmMIA - TYS
1 stop23h 55mMultiple Airlines
Sun 11/235:49 pmTYS - MIA
1 stop21h 41mMultiple Airlines
Deal found 10/29$194

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Key Largo to Knoxville that are best for you.

Fly from

Key Largo

Fly to

Knoxville

Route

Depart

Return

Price

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Tue 12/9

10:32 am-2:52 pm

1 stop4h 20m

Knoxville McGhee Tyson

Mon 12/15

7:59 pm-12:46 am

1 stop4h 47m

$179

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 12/10

6:00 am-9:38 am

1 stop3h 38m

Knoxville McGhee Tyson

Sun 12/14

7:59 pm-12:46 am

1 stop4h 47m

$179

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 1/8

12:00 pm-5:13 pm

1 stop5h 13m

Knoxville McGhee Tyson

Tue 1/13

5:30 am-10:40 am

1 stop5h 10m

$199

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 12/4

12:36 pm-6:52 pm

1 stop6h 16m

Knoxville McGhee Tyson

Sun 12/7

7:59 pm-12:46 am

1 stop4h 47m

$209

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 12/6

8:05 am-2:50 pm

1 stop6h 45m

Knoxville McGhee Tyson

Wed 12/10

6:10 am-12:24 pm

1 stop6h 14m

$209

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 11/13

12:00 pm-8:00 pm

1 stop8h 00m

Knoxville McGhee Tyson

Tue 12/2

7:59 pm-12:46 am

1 stop4h 47m

$226

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 12/12

8:05 am-2:52 pm

1 stop6h 47m

Knoxville McGhee Tyson

Tue 12/16

12:27 pm-6:50 pm

1 stop6h 23m

$247

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 11/13

12:00 pm-8:00 pm

1 stop8h 00m

Knoxville McGhee Tyson

Mon 11/17

8:07 pm-12:46 am

1 stop4h 39m

$269

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 11/13

12:00 pm-8:00 pm

1 stop8h 00m

Knoxville McGhee Tyson

Tue 11/18

2:41 pm-6:25 pm

1 stop3h 44m

$269

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 12/17

2:11 pm-6:58 pm

1 stop4h 47m

Knoxville McGhee Tyson

Wed 12/31

8:35 am-12:56 pm

1 stop4h 21m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 22 results
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Best time to book a flight from Key Largo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Knoxville

How far ahead should I book a flight from Key Largo to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Knoxville. Price data was last updated on October 24, 2025.

Booking 62 days in advance of your planned departure date is, on average, the best time to get cheap flights from Key Largo to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Key Largo to Knoxville?

Currently, April is the cheapest month in which you can book a flight from Key Largo to Knoxville (average of $62). Flying from Key Largo to Knoxville in March is currently the most expensive (average of $92). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to TYS?

Find hourly flight availability from Key Largo to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

When flying from Key Largo to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 39% versus a flight in the evening.

What is the cheapest day to fly from Key Largo to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Knoxville. Price data was last updated on October 26, 2025.

Travelers seeking maximum savings on their Key Largo to Knoxville flight should consider departing on Tuesday at noon when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 30, 2025.
Read through reviews of airlines operating flights from Key Largo to Knoxville, such as Delta, American Airlines, and Allegiant Air. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,993 reviews

Overall

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
7,993 reviews
Delta
7.9
Good
7,993 reviews

Overall

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,030 reviews
Delta
7.9
Good
7,993 reviews

Overall

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Allegiant Air
7.2
Good
695 reviews
Delta
7.9
Good
7,993 reviews

Overall

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Key Largo?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Key Largo. On average, McGhee Tyson has 1 inbound flight from Key Largo per day from 3 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Key Largo to Knoxville?

    Airlines like Delta fly from Key Largo to Knoxville in about 4h 20m. The time it takes to get you to your destination can typically vary by up to . The distance from Key Largo to Knoxville is about 725 mi.

  • What are the most reliable airlines from Key Largo to Knoxville?

    Consider American Airlines (88%), Qatar Airways (88%) or Envoy Air (88%) when booking your flight. These represent the most reliable airlines when flying from Key Largo to Knoxville.

  • What are the cheapest flights from Key Largo to Knoxville?

    The cheapest flight price from Key Largo to Knoxville is $264. On average you can expect to pay $526. The most popular route, (Miami - Knoxville McGhee Tyson), can usually be booked for $179.

  • Can I find deals for flights from Key Largo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Key Largo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Knoxville.

  • Can I find deals for business class flights from Key Largo to Knoxville?

    Yes. Cheapflights offers flight deals from Key Largo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Knoxville?

    Currently, April is the cheapest month in which you can book a flight from Key Largo to Knoxville (average of $62). Flying from Key Largo to Knoxville in March is currently the most expensive (average of $92). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Key Largo to Knoxville

Discover the top 3 airlines that operate flights from Key Largo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$92Average$198FlexibilityNo cancel feeOn-time88%
DeltaCheapest$182Average$358FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$192Average$383FlexibilityNo cancel feeOn-time71%

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