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$114+ Cheap flights from Key Largo, FL to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/30. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — TYS
Aug 7 — Aug 141
Thu 8/7
Thu 8/14
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to Knoxville McGhee Tyson are usually found in July or October, booked 36 days in advance, depart on a Tuesday or Wednesday and return on a Monday

Cheap flight deals from Key Largo to Knoxville

Keep the following information in mind while searching for Key Largo to Knoxville flight deals. Data was last updated August 2, 2025.

Round-trip from

$159
(American Airlines)

One-way from

$114
(Delta)

Popular in

March

Cheapest in

July

Average price

$312
From Key Largo to Knoxville McGhee Tyson
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One-way flight from Key Largo to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 2% potential increase in price ($9 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Key Largo to Knoxville

Cheapest flights from Key Largo to Knoxville
Explore the most affordable flight options available from Key Largo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 2, 2025.

This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/279:35 pmMIA - TYS
Nonstop2h 15mAmerican Airlines
Tue 9/306:10 amTYS - MIA
Nonstop2h 08mAmerican Airlines
Deal found 8/1$159
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/306:00 amMIA - TYS
1 stop4h 27mDelta
Wed 9/35:45 amTYS - MIA
1 stop3h 38mDelta
Deal found 8/1$194
This Mytrip deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/28:04 pmMIA - TYS
1 stop15h 51mMultiple Airlines
Sun 10/57:20 amTYS - MIA
1 stop16h 39mMultiple Airlines
Deal found 8/1$238
This Frontier deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/216:00 amMIA - TYS
1 stop13h 41mFrontier
Sun 8/248:33 pmTYS - MIA
1 stop9h 57mFrontier
Deal found 8/1$257
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1411:09 amMIA - TYS
2 stops12h 50mUnited Airlines
Mon 11/175:45 amTYS - MIA
1 stop5h 29mUnited Airlines
Deal found 7/31$312

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 2, 2025.
Use the filters below to find and compare flights from Key Largo to Knoxville that are best for you.

Fly from

Key Largo

Fly to

Knoxville

Route

Depart

Return

Price

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 9/27

9:35 pm-11:50 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Tue 9/30

6:10 am-8:18 am

Nonstop2h 08m

$159

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 8/30

6:00 am-10:27 am

1 stop4h 27m

Knoxville McGhee Tyson

Wed 9/3

5:45 am-9:23 am

1 stop3h 38m

$194

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 10/2

8:04 pm-11:55 am

1 stop15h 51m

Knoxville McGhee Tyson

Sun 10/5

7:20 am-11:59 pm

1 stop16h 39m

$238

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 8/21

6:00 am-7:41 pm

1 stop13h 41m

Knoxville McGhee Tyson

Sun 8/24

8:33 pm-6:30 am

1 stop9h 57m

$257

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 11/14

11:09 am-11:59 pm

2 stops12h 50m

Knoxville McGhee Tyson

Mon 11/17

5:45 am-11:14 am

1 stop5h 29m

$312

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 8/30

6:00 am-10:27 am

1 stop4h 27m

$114

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Tue 8/19

7:53 pm-11:54 am

1 stop16h 01m

$124

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sun 9/28

6:00 am-4:18 pm

1 stop10h 18m

$129

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 9/27

4:17 pm-10:50 pm

1 stop6h 33m

$154

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 8/30

9:35 pm-12:17 pm

2 stops14h 42m

$229

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/31

Best time to book a flight from Key Largo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Knoxville

How far ahead should I book a flight from Key Largo to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to Knoxville. Price data was last updated on August 1, 2025.

Booking 36 days in advance of your planned departure date is, on average, the best time to get cheap flights from Key Largo to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Key Largo to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Key Largo to Knoxville (average of $294). Flying from Key Largo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to TYS?

Find hourly flight availability from Key Largo to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 2, 2025.

When flying from Key Largo to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Key Largo to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to Knoxville flight should consider departing on Sunday mornings when fares are most often at their lowest. Monday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 2, 2025.
Read through reviews of airlines operating flights from Key Largo to Knoxville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,983 reviews

Overall

8.0

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,983 reviews
Delta
8.0
Very good
7,983 reviews

Overall

8.0

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
8,904 reviews
Delta
8.0
Very good
7,983 reviews

Overall

8.0

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,983 reviews

Overall

8.0

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Frontier
5.9
Fair
3,241 reviews
Delta
8.0
Very good
7,983 reviews

Overall

8.0

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Key Largo?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Key Largo. On average, McGhee Tyson has 1 inbound flight from Key Largo per day from 3 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • What are the cheapest airlines to fly from Key Largo to Knoxville one-way?

    $114 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on Frontier and United Airlines, with prices starting from $129 and $154, respectively.

  • What are the most reliable airlines from Key Largo to Knoxville?

    Consider Republic Airways (50%), Qatar Airways (49%) or American Airlines (41%) when booking your flight. These represent the most reliable airlines when flying from Key Largo to Knoxville.

  • What are the cheapest flights from Key Largo to Knoxville?

    The cheapest flight price from Key Largo to Knoxville is $159. On average you can expect to pay $479. The most popular route, (Miami - Knoxville McGhee Tyson), can usually be booked for $194.

  • Can I find deals for flights from Key Largo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Key Largo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Knoxville.

  • Can I find deals for business class flights from Key Largo to Knoxville?

    Yes. Cheapflights offers flight deals from Key Largo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Key Largo to Knoxville (average of $294). Flying from Key Largo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Key Largo to Knoxville

Discover the top 3 airlines that operate flights from Key Largo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$91Average$196FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$197Average$378FlexibilityNo cancel feeOn-time71%
DeltaCheapest$198Average$320FlexibilityNo cancel feeOn-timeN/A

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