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$110+ Cheap flights from Durham, NC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/14. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — TYS
nov 30 — dic 71
dom 11/30
dom 12/7
1 adult, Economy
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Cheap flight deals from Durham to Knoxville

Keep the following information in mind while searching for Durham to Knoxville flight deals. Data was last updated ottobre 31, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$228
(Kiwi.com)

One-way from

$110
(Kiwi.com)

Popular in

May

Cheapest in

August

Average price

$396
Provider with most accurate pricing for Raleigh-Durham-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Raleigh-Durham-Knoxville McGhee Tyson flights.
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From Durham to Knoxville McGhee Tyson
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One-way flight from Durham to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 8% potential increase in price ($32 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Durham to Knoxville

Cheapest flights from Durham to Knoxville
Explore the most affordable flight options available from Durham to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on ottobre 31, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven 11/149:28 amRDU - TYS
1 stop27h 33mMultiple Airlines
lun 11/1710:15 amTYS - RDU
1 stop5h 07mMultiple Airlines
Deal found 10/29$228
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 11/209:06 amRDU - TYS
1 stop13h 20mMultiple Airlines
ven 11/2110:32 amTYS - RDU
1 stop10h 04mMultiple Airlines
Deal found 10/29$250
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom 12/149:06 amRDU - TYS
1 stop13h 36mMultiple Airlines
dom 12/219:08 amTYS - RDU
1 stop7h 47mMultiple Airlines
Deal found 10/30$252
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven 11/144:13 pmRDU - TYS
1 stop17h 14mMultiple Airlines
dom 11/166:30 amTYS - RDU
1 stop14h 41mMultiple Airlines
Deal found 10/30$266
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 11/137:05 pmRDU - TYS
2 stops18h 07mMultiple Airlines
lun 11/1710:15 amTYS - RDU
1 stop5h 07mMultiple Airlines
Deal found 10/29$270
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven 12/125:50 pmRDU - TYS
1 stop18h 13mMultiple Airlines
dom 12/146:30 amTYS - RDU
1 stop11h 01mMultiple Airlines
Deal found 10/28$286
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun 11/39:37 pmRDU - TYS
1 stop17h 29mMultiple Airlines
ven 11/78:40 amTYS - RDU
1 stop6h 42mMultiple Airlines
Deal found 10/30$287
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 11/137:05 pmRDU - TYS
2 stops22h 47mMultiple Airlines
dom 11/166:30 amTYS - RDU
1 stop14h 41mMultiple Airlines
Deal found 10/29$291

Cheapflights Fare Finder

 
Customize your flight search to find flights from Durham to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated ottobre 31, 2025.
Use the filters below to find and compare flights from Durham to Knoxville that are best for you.

Fly from

Durham

Fly to

Knoxville

Route

Depart

Return

Price

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

ven 11/14

9:28 am-1:01 pm

1 stop27h 33m

Knoxville McGhee Tyson

lun 11/17

10:15 am-3:22 pm

1 stop5h 07m

$228

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

gio 2/19

9:09 am-9:21 pm

1 stop12h 12m

Knoxville McGhee Tyson

dom 2/22

11:50 am-7:24 pm

1 stop7h 34m

$241

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

gio 11/20

9:06 am-10:26 pm

1 stop13h 20m

Knoxville McGhee Tyson

ven 11/21

10:32 am-8:36 pm

1 stop10h 04m

$250

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

dom 12/14

9:06 am-10:42 pm

1 stop13h 36m

Knoxville McGhee Tyson

dom 12/21

9:08 am-4:55 pm

1 stop7h 47m

$252

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

gio 11/27

6:42 pm-7:19 pm

1 stop24h 37m

Knoxville McGhee Tyson

gio 12/4

1:22 pm-7:12 pm

1 stop5h 50m

$257

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

ven 11/14

4:13 pm-9:27 am

1 stop17h 14m

Knoxville McGhee Tyson

dom 11/16

6:30 am-9:11 pm

1 stop14h 41m

$266

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

ven 12/12

5:50 pm-12:03 pm

1 stop18h 13m

Knoxville McGhee Tyson

dom 12/14

6:30 am-5:31 pm

1 stop11h 01m

$286

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

gio 11/13

7:05 pm-5:52 pm

2 stops22h 47m

Knoxville McGhee Tyson

dom 11/16

6:30 am-9:11 pm

1 stop14h 41m

$291

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

dom 12/14

9:06 am-10:42 pm

1 stop13h 36m

$110

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

ven 11/14

4:13 pm-5:22 pm

1 stop25h 09m

$121

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 17 results
1
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Best time to book a flight from Durham to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Knoxville

What is the cheapest month to book a flight from Durham to Knoxville?

Currently, November is the cheapest month in which you can book a flight from Durham to Knoxville (average of $133). Flying from Durham to Knoxville in September is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to TYS?

Find hourly flight availability from Durham to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated ottobre 31, 2025.

A simple way to save on the total cost of your ticket is to fly from Durham to Knoxville in the afternoon. If you’re flexible enough to do this you can expect to save up to 30% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated ottobre 31, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Durham to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,998 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Durham to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Durham?

    If you book a flight to Knoxville from Durham, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Durham to McGhee Tyson per day from 3 different airlines.

  • Can I find deals for flights from Durham to Knoxville that include hotel bookings?

    Yes. In addition to deals on Durham to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Knoxville.

  • Can I find deals for business class flights from Durham to Knoxville?

    Yes. Cheapflights offers flight deals from Durham to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Durham to Knoxville?

    Currently, November is the cheapest month in which you can book a flight from Durham to Knoxville (average of $133). Flying from Durham to Knoxville in September is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Durham to Knoxville

Discover the top 3 airlines that operate flights from Durham to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated ottobre 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$218Average$328FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$426FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$366FlexibilityNo cancel feeOn-timeN/A

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