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$163+ Cheap flights from Durham, NC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — TYS
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Durham to Knoxville

Keep the following information in mind while searching for Durham to Knoxville flight deals. Data was last updated May 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$219
(United Airlines)

One-way from

$163
(Trip.com)

Popular in

May

Cheapest in

July

Average price

$529
Provider with most accurate pricing for Raleigh-Durham-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Raleigh-Durham-Knoxville McGhee Tyson flights.
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From Durham to Knoxville McGhee Tyson
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One-way flight from Durham to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 7% potential increase in price ($29 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from Durham to Knoxville

Cheapest flights from Durham to Knoxville
Explore the most affordable flight options available from Durham to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1011:08 amRDU - TYS
1 stop4h 07mDelta
Tue 6/175:57 pmTYS - RDU
1 stop5h 25mDelta
Deal found 4/29$219
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/145:34 amRDU - TYS
1 stop2h 59mAmerican Airlines
Sat 6/218:13 pmTYS - RDU
1 stop3h 46mAmerican Airlines
Deal found 4/30$220
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/306:00 amRDU - TYS
1 stop4h 27mUnited Airlines
Fri 6/65:45 amTYS - RDU
1 stop3h 43mUnited Airlines
Deal found 4/30$222
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/138:00 amRDU - TYS
2 stops38h 41mMultiple Airlines
Fri 6/207:15 amTYS - RDU
1 stop10h 26mMultiple Airlines
Deal found 4/29$261

Cheapflights Fare Finder

Customize your flight search to find flights from Durham to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Durham to Knoxville that are best for you.

Fly from

Durham

Fly to

Knoxville

Route

Depart

Return

Price

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Tue 6/10

11:08 am-3:15 pm

1 stop4h 07m

Knoxville McGhee Tyson

Tue 6/17

5:57 pm-11:22 pm

1 stop5h 25m

$219

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Sat 6/14

5:34 am-8:33 am

1 stop2h 59m

Knoxville McGhee Tyson

Sat 6/21

8:13 pm-11:59 pm

1 stop3h 46m

$220

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Fri 5/30

6:00 am-10:27 am

1 stop4h 27m

Knoxville McGhee Tyson

Fri 6/6

5:45 am-9:28 am

1 stop3h 43m

$222

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Fri 6/13

8:00 am-10:41 pm

2 stops38h 41m

Knoxville McGhee Tyson

Fri 6/20

7:15 am-5:41 pm

1 stop10h 26m

$261

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Thu 5/8

12:17 pm-11:39 pm

1 stop11h 22m

$163

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Wed 5/14

5:00 am-8:24 am

1 stop3h 24m

$265

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Wed 5/14

6:00 am-4:54 pm

2 stops10h 54m

$270

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Tue 5/6

6:25 am-11:09 am

1 stop4h 44m

$341

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Best time to book a flight from Durham to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Knoxville

What is the cheapest month to book a flight from Durham to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Durham to Knoxville (average of $296). Flying from Durham to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to TYS?

Find hourly flight availability from Durham to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Durham to Knoxville as you normally would.

What is the cheapest day to fly from Durham to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Durham to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Durham to Knoxville flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated May 1, 2025.
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Durham to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Durham?

    If you book a flight to Knoxville from Durham, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Durham to McGhee Tyson per day from 3 different airlines.

  • What are the cheapest airlines to fly from Durham to Knoxville one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $265. However, be on the lookout for offers from United Airlines and Delta, as they are both options that can get you from Durham to Knoxville for a low price.

  • Can I find deals for flights from Durham to Knoxville that include hotel bookings?

    Yes. In addition to deals on Durham to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Knoxville.

  • Can I find deals for business class flights from Durham to Knoxville?

    Yes. Cheapflights offers flight deals from Durham to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Durham to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Durham to Knoxville (average of $296). Flying from Durham to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Durham?

Book flights to Durham if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Top 3 airlines flying from Durham to Knoxville

Discover the top 3 airlines that operate flights from Durham to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$409FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$223Average$328FlexibilityNo cancel feeOn-time69%
DeltaCheapest$228Average$303FlexibilityNo cancel feeOn-timeN/A

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