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Knoxville

$118+ Cheap flights from Durham, NC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/17. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — TYS
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Durham to Knoxville

Cheapest flights from Durham to Knoxville
Explore the most affordable flight options available from Durham to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/89:56 pm
RDU
-
TYS
1 stop19h 32m
Multiple Airlines
Thu 2/126:30 am
TYS
-
RDU
1 stop5h 46m
Multiple Airlines
Deal found 1/28$251
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:08 pm
RDU
-
TYS
1 stop17h 52m
Multiple Airlines
Sun 3/86:30 am
TYS
-
RDU
1 stop8h 41m
Multiple Airlines
Deal found 1/27$272
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:10 am
RDU
-
TYS
2 stops15h 57m
Multiple Airlines
Sun 3/111:50 am
TYS
-
RDU
1 stop7h 34m
Multiple Airlines
Deal found 1/27$277
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/195:03 am
RDU
-
TYS
1 stop3h 39m
American Airlines
Thu 2/267:02 am
TYS
-
RDU
1 stop3h 31m
American Airlines
Deal found 1/27$281
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/74:50 pm
RDU
-
TYS
1 stop4h 25m
Southwest
Sat 5/96:40 am
TYS
-
RDU
2 stops12h 15m
Southwest
Deal found 1/27$292
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:45 am
RDU
-
TYS
1 stop5h 20m
Southwest
Wed 7/228:10 am
TYS
-
RDU
1 stop4h 40m
Southwest
Deal found 1/27$307
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:25 am
RDU
-
TYS
2 stops14h 50m
Southwest
Sun 3/87:25 pm
TYS
-
RDU
1 stop4h 25m
Southwest
Deal found 1/27$310
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/610:33 am
RDU
-
TYS
1 stop7h 54m
Multiple Airlines
Sun 3/86:30 am
TYS
-
RDU
1 stop8h 41m
Multiple Airlines
Deal found 1/27$312
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/311:20 am
RDU
-
TYS
1 stop7h 25m
Southwest
Sun 4/56:35 am
TYS
-
RDU
1 stop5h 35m
Southwest
Deal found 1/27$317

Find flight deals from Durham to Knoxville

Keep the following information in mind while searching for Durham to Knoxville flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$251
(Kiwi.com)

One-way from

$118
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$351
Provider with most accurate pricing for Raleigh-Durham-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Raleigh-Durham-Knoxville McGhee Tyson flights.
Search Deals
From Durham to Knoxville McGhee Tyson
Search Deals
One-way flight from Durham to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($60 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Durham to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Durham to Knoxville that are best for you.

Fly from

Durham

Fly to

Knoxville

Route

Depart

Return

Price

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Sun 2/8

9:56 pm-5:28 pm

1 stop19h 32m

Knoxville McGhee Tyson

Thu 2/12

6:30 am-12:16 pm

1 stop5h 46m

$251

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Thu 3/5

6:08 pm-12:00 pm

1 stop17h 52m

Knoxville McGhee Tyson

Sun 3/8

6:30 am-3:11 pm

1 stop8h 41m

$272

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Thu 2/19

5:03 am-8:42 am

1 stop3h 39m

Knoxville McGhee Tyson

Thu 2/26

7:02 am-10:33 am

1 stop3h 31m

$281

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Thu 3/5

6:25 am-9:15 pm

2 stops14h 50m

Knoxville McGhee Tyson

Sun 3/8

7:25 pm-11:50 pm

1 stop4h 25m

$310

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Fri 4/3

6:25 pm-11:57 pm

1 stop5h 32m

Knoxville McGhee Tyson

Sun 4/5

5:40 am-9:06 am

1 stop3h 26m

$317

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Fri 3/6

6:10 am-12:45 pm

1 stop6h 35m

Knoxville McGhee Tyson

Sun 3/8

7:25 pm-9:40 am

2 stops14h 15m

$328

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Fri 4/3

6:25 am-9:15 pm

2 stops14h 50m

Knoxville McGhee Tyson

Sun 4/5

7:25 pm-11:20 pm

1 stop3h 55m

$328

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Thu 2/5

9:09 am-11:10 pm

1 stop14h 01m

Knoxville McGhee Tyson

Sun 2/8

7:31 pm-12:11 am

2 stops28h 40m

$343

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Sat 3/28

7:59 pm-11:57 pm

1 stop3h 58m

Knoxville McGhee Tyson

Fri 4/3

5:40 am-9:06 am

1 stop3h 26m

$383

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Thu 2/26

8:00 pm-10:12 am

2 stops14h 12m

Knoxville McGhee Tyson

Sun 3/1

6:45 am-11:44 pm

2 stops16h 59m

$567

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/29

Showing 1-10 of 19 results
1
2

Best time to book a flight from Durham to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Knoxville

What is the cheapest month to book a flight from Durham to Knoxville?

Currently, November is the cheapest month in which you can book a flight from Durham to Knoxville (average of $113). Flying from Durham to Knoxville in September is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 29, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Durham to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Boarding

8.1

Food

7.2

Overall

7.9

Crew

8.5

Entertainment

7.8

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Boarding

8.1

Food

7.2

Overall

7.9

Crew

8.5

Entertainment

7.8

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,205 reviews
Delta
7.9
Good
8,128 reviews

Boarding

8.1

Food

7.2

Overall

7.9

Crew

8.5

Entertainment

7.8

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Durham to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Durham?

    If you book a flight to Knoxville from Durham, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Durham to McGhee Tyson per day from 2 different airlines.

  • How long is the flight from Durham to Knoxville?

    A quick flight from Durham to Knoxville can take about 3h 39m. American Airlines provides one of the quickest options available for as low as $281. The distance from Durham to Knoxville is about 291 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Durham to Knoxville that include hotel bookings?

    Yes. In addition to deals on Durham to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Knoxville.

  • Can I find deals for business class flights from Durham to Knoxville?

    Yes. Cheapflights offers flight deals from Durham to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Durham to Knoxville?

    Currently, November is the cheapest month in which you can book a flight from Durham to Knoxville (average of $113). Flying from Durham to Knoxville in September is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Durham to Knoxville

Discover the top 2 airlines that operate flights from Durham to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$366FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$223Average$420FlexibilityNo cancel feeOn-time71%

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