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$102+ Cheap flights from Durham, NC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — TYS
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
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Cheap flight deals from Durham to Knoxville

Keep the following information in mind while searching for Durham to Knoxville flight deals. Data was last updated July 31, 2025.

Round-trip from

$219
(American Airlines)

One-way from

$102
(Mytrip)

Popular in

May

Cheapest in

January

Average price

$265
From Durham to Knoxville McGhee Tyson
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One-way flight from Durham to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 9% potential increase in price ($35 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Durham to Knoxville

Cheapest flights from Durham to Knoxville
Explore the most affordable flight options available from Durham to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/305:20 amRDU - TYS
1 stop5h 36mDelta
Mon 10/68:10 pmTYS - RDU
1 stop3h 52mDelta
Deal found 7/31$219
This Mytrip deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/217:56 pmRDU - TYS
1 stop14h 38mMultiple Airlines
Sun 8/249:12 pmTYS - RDU
2 stops16h 35mMultiple Airlines
Deal found 7/31$224
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:40 pmRDU - TYS
1 stop4h 19mUnited Airlines
Sat 12/275:45 amTYS - RDU
1 stop3h 54mUnited Airlines
Deal found 7/31$256
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/305:00 amRDU - TYS
1 stop3h 34mAmerican Airlines
Sat 8/25:05 amTYS - RDU
1 stop2h 54mAmerican Airlines
Deal found 7/30$259

Cheapflights Fare Finder

 
Customize your flight search to find flights from Durham to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Durham to Knoxville that are best for you.

Fly from

Durham

Fly to

Knoxville

Route

Depart

Return

Price

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Tue 9/30

5:20 am-10:56 am

1 stop5h 36m

Knoxville McGhee Tyson

Mon 10/6

8:10 pm-12:02 am

1 stop3h 52m

$219

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Thu 8/21

7:56 pm-10:34 am

1 stop14h 38m

Knoxville McGhee Tyson

Sun 8/24

9:12 pm-1:47 pm

2 stops16h 35m

$224

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Mon 12/22

7:40 pm-11:59 pm

1 stop4h 19m

Knoxville McGhee Tyson

Sat 12/27

5:45 am-9:39 am

1 stop3h 54m

$256

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Fri 10/3

7:16 pm-11:03 pm

1 stop3h 47m

Knoxville McGhee Tyson

Wed 10/8

8:15 am-11:19 am

1 stop3h 04m

$279

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Thu 9/25

9:23 am-5:05 pm

1 stop7h 42m

$102

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Best time to book a flight from Durham to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Knoxville

What is the cheapest month to book a flight from Durham to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Durham to Knoxville (average of $294). Flying from Durham to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to TYS?

Find hourly flight availability from Durham to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Durham to Knoxville as you normally would.

What is the cheapest day to fly from Durham to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Durham to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Durham to Knoxville flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 31, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Durham to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Food

7.3

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,900 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Durham to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Durham?

    If you book a flight to Knoxville from Durham, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Durham to McGhee Tyson per day from 3 different airlines.

  • Can I find deals for flights from Durham to Knoxville that include hotel bookings?

    Yes. In addition to deals on Durham to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Knoxville.

  • Can I find deals for business class flights from Durham to Knoxville?

    Yes. Cheapflights offers flight deals from Durham to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Durham to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Durham to Knoxville (average of $294). Flying from Durham to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Durham to Knoxville

Discover the top 3 airlines that operate flights from Durham to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$419FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$323FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$223Average$328FlexibilityNo cancel feeOn-time69%

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