$109+ Cheap flights from Durham, NC to Knoxville (TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/23. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — TYS
Apr 16 — Apr 231
Round-trip
1 adult, Economy
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Best
Last-minute
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Cheapest flights from Durham to KnoxvilleExplore the most affordable flight options available from Durham to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 17, 2026.
Explore the most affordable flight options available from Durham to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2410:38 pm
RDU
- TYS
1 stop14h 13m
Multiple Airlines
Thu 3/266:55 pm
TYS
- RDU
1 stop12h 57m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/179:37 pm
RDU
- TYS
1 stop14h 29m
Multiple Airlines
Mon 4/201:15 pm
TYS
- RDU
1 stop19h 45m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:05 am
RDU
- TYS
1 stop15h 15m
Multiple Airlines
Mon 5/111:15 pm
TYS
- RDU
1 stop20h 06m
Multiple Airlines
Deal found 3/14![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:32 pm
RDU
- TYS
1 stop9h 05m
Multiple Airlines
Mon 6/157:22 pm
TYS
- RDU
1 stop12h 58m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:46 pm
RDU
- TYS
2 stops19h 55m
Multiple Airlines
Sun 4/124:31 pm
TYS
- RDU
1 stop18h 43m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/289:40 am
RDU
- TYS
2 stops32h 09m
Multiple Airlines
Wed 4/18:30 am
TYS
- RDU
1 stop24h 30m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:03 pm
RDU
- TYS
1 stop17h 03m
Multiple Airlines
Sun 5/1712:55 pm
TYS
- RDU
1 stop9h 48m
Multiple Airlines
Deal found 3/14![Multiple Airlines logo]()
$267
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/83:50 pm
RDU
- TYS
1 stop5h 00m
Southwest
Tue 4/145:50 pm
TYS
- RDU
1 stop3h 45m
Southwest
Deal found 3/16![Southwest logo]()
$279
Best flights from Durham to KnoxvilleDiscover carefully curated flight deals from Durham to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 17, 2026.
Discover carefully curated flight deals from Durham to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 17, 2026.
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/89:50 am
RDU
- TYS
2 stops9h 50m
Southwest
Tue 4/147:05 am
TYS
- RDU
2 stops9h 25m
Southwest
Deal found 3/16![Southwest logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/274:07 pm
RDU
- TYS
2 stops28h 44m
Multiple Airlines
Tue 4/72:56 pm
TYS
- RDU
1 stop27h 48m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/99:56 am
RDU
- TYS
1 stop5h 09m
Delta
Mon 5/117:33 pm
TYS
- RDU
1 stop4h 43m
Delta
Deal found 3/17![Delta logo]()
$331
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:10 am
RDU
- TYS
1 stop5h 30m
Southwest
Sun 6/147:00 pm
TYS
- RDU
1 stop4h 20m
Southwest
Deal found 3/15![Southwest logo]()
$337
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/210:10 am
RDU
- TYS
2 stops11h 05m
Southwest
Sun 4/56:35 am
TYS
- RDU
2 stops6h 30m
Southwest
Deal found 3/13![Southwest logo]()
$423
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:00 am
RDU
- TYS
2 stops15h 05m
Southwest
Wed 4/16:35 am
TYS
- RDU
2 stops10h 40m
Southwest
Deal found 3/13![Southwest logo]()
$493
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:10 am
RDU
- TYS
2 stops10h 10m
Southwest
Sun 5/36:40 am
TYS
- RDU
2 stops6h 25m
Southwest
Deal found 3/14![Southwest logo]()
$503
Last-minute flights from Durham to KnoxvilleDiscover last-minute flight deals from Durham to Knoxville. Data last updated March 17, 2026 and is based on user searches.
Discover last-minute flight deals from Durham to Knoxville. Data last updated March 17, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/189:40 am
RDU
- TYS
2 stops31h 42m
Multiple Airlines
Mon 3/232:06 pm
TYS
- RDU
1 stop18h 31m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2410:38 pm
RDU
- TYS
1 stop14h 13m
Multiple Airlines
Thu 3/266:55 pm
TYS
- RDU
1 stop12h 57m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/289:40 am
RDU
- TYS
2 stops32h 09m
Multiple Airlines
Wed 4/18:30 am
TYS
- RDU
1 stop24h 30m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/308:10 pm
RDU
- TYS
1 stop15h 02m
Multiple Airlines
Wed 4/111:26 am
TYS
- RDU
2 stops12h 17m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$289
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/83:50 pm
RDU
- TYS
1 stop5h 00m
Southwest
Tue 4/148:15 am
TYS
- RDU
1 stop4h 35m
Southwest
Deal found 3/12![Southwest logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/179:37 pm
RDU
- TYS
1 stop14h 29m
Multiple Airlines
Mon 4/201:15 pm
TYS
- RDU
1 stop19h 45m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$228
One-way flights from Durham to KnoxvilleSearch for one-way flight options from Durham to Knoxville. Find affordable one-way fares based on user searches. Data last updated March 17, 2026.
Search for one-way flight options from Durham to Knoxville. Find affordable one-way fares based on user searches. Data last updated March 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/238:19 pm
RDU
- TYS
1 stop14h 53m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:46 pm
RDU
- TYS
1 stop14h 50m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:46 pm
RDU
- TYS
1 stop14h 50m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/59:05 pm
RDU
- TYS
1 stop21h 16m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$131
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/81:09 pm
RDU
- TYS
1 stop5h 04m
American Airlines
Deal found 3/12![American Airlines logo]()
$132
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/249:37 pm
RDU
- TYS
1 stop14h 29m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1110:16 pm
RDU
- TYS
1 stop25h 18m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$141
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/79:50 am
RDU
- TYS
2 stops9h 50m
Southwest
Deal found 3/16![Southwest logo]()
$145
Find flight deals from Durham to Knoxville
Keep the following information in mind while searching for Durham to Knoxville flight deals. Data was last updated March 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $228 (Kiwi.com) |
One-way from | $109 (Kiwi.com) |
Popular in | February |
Cheapest in | August |
Average price | $352 |
Cheapflights Fare Finder
Customize your flight search to find flights from Durham to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
Use the filters below to find and compare flights from Durham to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Wed 4/8
9:50 am-7:40 pm
2 stops9h 50m
Knoxville McGhee Tyson
Tue 4/14
7:05 am-4:30 pm
2 stops9h 25m
$289
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Fri 3/27
4:07 pm-8:51 pm
2 stops28h 44m
Knoxville McGhee Tyson
Tue 4/7
2:56 pm-6:44 pm
1 stop27h 48m
$317
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Sat 5/9
9:56 am-3:05 pm
1 stop5h 09m
Knoxville McGhee Tyson
Mon 5/11
7:33 pm-12:16 am
1 stop4h 43m
$331
Quickest round-trip
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Sat 5/30
6:10 am-11:40 am
1 stop5h 30m
Knoxville McGhee Tyson
Sun 6/14
7:00 pm-11:20 pm
1 stop4h 20m
$337
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Thu 4/2
10:10 am-9:15 pm
2 stops11h 05m
Knoxville McGhee Tyson
Sun 4/5
6:35 am-1:05 pm
2 stops6h 30m
$423
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Sat 3/28
6:00 am-9:05 pm
2 stops15h 05m
Knoxville McGhee Tyson
Wed 4/1
6:35 am-5:15 pm
2 stops10h 40m
$493
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Fri 5/1
10:10 am-8:20 pm
2 stops10h 10m
Knoxville McGhee Tyson
Sun 5/3
6:40 am-1:05 pm
2 stops6h 25m
$503
Cheapest one-way
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Wed 4/8
1:09 pm-6:13 pm
1 stop5h 04m
$132
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Tue 4/14
9:50 am-7:40 pm
2 stops9h 50m
$145
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Fri 4/24
9:37 pm-12:06 pm
1 stop14h 29m
$148
Showing 1-10 of 14 resultsSorted by cheapest first
Best time to book a flight from Durham to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Durham with our price prediction graph.
RDU-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Durham to Knoxville
DU8-TYS
RDU-TYS
What is the cheapest month to book a flight from Durham to Knoxville?
Currently, November is the cheapest month in which you can book a flight from Durham to Knoxville (average of $113). Flying from Durham to Knoxville in September is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated March 17, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Durham to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Comfort
7.9
Boarding
8.1
Overall
7.9
Food
7.2
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Comfort
7.9
Boarding
8.1
Overall
7.9
Food
7.2
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Comfort
7.9
Boarding
8.1
Overall
7.9
Food
7.2
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Durham to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge
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Other flights to Knoxville
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Durham and Knoxville flights
Browse other Durham and Knoxville flight options. Last updated on March 17, 2026.
Popular flight searches
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Durham to Knoxville flights
Consider these flights traveling from Durham to Knoxville.
Top 2 airlines flying from Durham to Knoxville
Discover the top 2 airlines that operate flights from Durham to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$218 | Average$407 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$218 | Average$391 | FlexibilityNo cancel fee | On-timeN/A |