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Knoxville

$108+ Cheap flights from Durham, NC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — TYS
out 11 — out 181
sáb 10/11
sáb 10/18
1 adult, Economy
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Cheap flight deals from Durham to Knoxville

Keep the following information in mind while searching for Durham to Knoxville flight deals. Data was last updated setembro 11, 2025.

Round-trip from

$241
(Kiwi.com)

One-way from

$112
(Kiwi.com)

Popular in

May

Cheapest in

October

Average price

$358
From Durham to Knoxville McGhee Tyson
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One-way flight from Durham to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 12% potential increase in price ($48 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Durham to Knoxville

Cheapest flights from Durham to Knoxville
Explore the most affordable flight options available from Durham to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on setembro 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 10/283:40 pmRDU - TYS
1 stop3h 21mAmerican Airlines
sáb 11/14:18 pmTYS - RDU
1 stop5h 48mAmerican Airlines
Deal found 9/11$183
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 10/146:00 amRDU - TYS
1 stop4h 29mUnited Airlines
sáb 10/187:26 pmTYS - RDU
1 stop4h 33mUnited Airlines
Deal found 9/11$217
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 10/138:15 pmRDU - TYS
1 stop3h 35mAmerican Airlines
sáb 10/257:00 amTYS - RDU
1 stop3h 29mAmerican Airlines
Deal found 9/11$236
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 9/259:23 amRDU - TYS
1 stop7h 42mMultiple Airlines
dom 9/283:19 pmTYS - RDU
1 stop3h 53mMultiple Airlines
Deal found 9/10$241
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 10/131:05 pmRDU - TYS
2 stops10h 11mMultiple Airlines
sáb 10/184:26 pmTYS - RDU
1 stop21h 54mMultiple Airlines
Deal found 9/11$246
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 11/146:10 amRDU - TYS
2 stops16h 46mMultiple Airlines
dom 11/166:30 amTYS - RDU
1 stop14h 41mMultiple Airlines
Deal found 9/9$251
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 10/29:49 pmRDU - TYS
1 stop14h 06mMultiple Airlines
dom 10/55:44 pmTYS - RDU
1 stop20h 39mMultiple Airlines
Deal found 9/10$252
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 10/248:01 amRDU - TYS
1 stop9h 53mMultiple Airlines
dom 10/265:34 pmTYS - RDU
1 stop20h 49mMultiple Airlines
Deal found 9/8$260
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 10/169:06 amRDU - TYS
1 stop7h 38mMultiple Airlines
dom 10/195:34 pmTYS - RDU
1 stop20h 49mMultiple Airlines
Deal found 9/8$273
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 11/65:00 amRDU - TYS
1 stop3h 34mAmerican Airlines
sáb 11/86:30 amTYS - RDU
1 stop6h 07mAmerican Airlines
Deal found 9/9$282

Cheapflights Fare Finder

 
Customize your flight search to find flights from Durham to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated setembro 11, 2025.
Use the filters below to find and compare flights from Durham to Knoxville that are best for you.

Fly from

Durham

Fly to

Knoxville

Route

Depart

Return

Price

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

ter 10/14

6:00 am-10:29 am

1 stop4h 29m

Knoxville McGhee Tyson

sáb 10/18

7:26 pm-11:59 pm

1 stop4h 33m

$217

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

qui 9/25

9:23 am-5:05 pm

1 stop7h 42m

Knoxville McGhee Tyson

dom 9/28

3:19 pm-7:12 pm

1 stop3h 53m

$241

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

qui 10/2

9:49 pm-11:55 am

1 stop14h 06m

Knoxville McGhee Tyson

dom 10/5

5:44 pm-2:23 pm

1 stop20h 39m

$252

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

seg 10/13

1:05 pm-11:16 pm

2 stops10h 11m

Knoxville McGhee Tyson

sáb 10/25

8:00 am-10:21 am

1 stop26h 21m

$287

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

sex 9/26

12:21 pm-5:34 pm

1 stop5h 13m

Knoxville McGhee Tyson

ter 9/30

8:00 am-6:03 pm

2 stops34h 03m

$294

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

qua 10/15

6:15 am-1:25 pm

1 stop7h 10m

Knoxville McGhee Tyson

dom 10/19

8:50 am-2:01 pm

1 stop5h 11m

$296

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

qui 10/9

5:24 am-9:32 am

1 stop4h 08m

Knoxville McGhee Tyson

qui 10/16

7:00 am-10:31 am

1 stop3h 31m

$338

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

sex 9/26

5:04 pm-11:43 pm

1 stop6h 39m

Knoxville McGhee Tyson

ter 9/30

10:51 am-5:06 pm

1 stop6h 15m

$345

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

sex 10/17

7:59 pm-11:46 pm

1 stop3h 47m

Knoxville McGhee Tyson

seg 10/20

8:10 pm-12:17 am

1 stop4h 07m

$354

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

qui 9/25

9:23 am-5:05 pm

1 stop7h 42m

Knoxville McGhee Tyson

ter 9/30

8:00 am-6:03 pm

2 stops34h 03m

$358

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Showing 1-10 of 15 results
1
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Best time to book a flight from Durham to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Knoxville

What is the cheapest month to book a flight from Durham to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Durham to Knoxville (average of $294). Flying from Durham to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to TYS?

Find hourly flight availability from Durham to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated setembro 11, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Durham to Knoxville as you normally would.

What is the cheapest day to fly from Durham to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Durham to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Durham to Knoxville flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated setembro 11, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Durham to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Durham to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Durham?

    If you book a flight to Knoxville from Durham, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Durham to McGhee Tyson per day from 3 different airlines.

  • How long is the flight from Durham to Knoxville?

    A quick flight from Durham to Knoxville can take about 4h 29m. United Airlines provides one of the quickest options available for as low as $217. The distance from Durham to Knoxville is about 291 mi.

  • Can I find deals for flights from Durham to Knoxville that include hotel bookings?

    Yes. In addition to deals on Durham to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Knoxville.

  • Can I find deals for business class flights from Durham to Knoxville?

    Yes. Cheapflights offers flight deals from Durham to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Durham to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Durham to Knoxville (average of $294). Flying from Durham to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Durham to Knoxville

Discover the top 3 airlines that operate flights from Durham to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated setembro 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$218Average$328FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$411FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$303FlexibilityNo cancel feeOn-timeN/A

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