$443+ Cheap flights from Panama City, FL to Key West (ECP - EYW)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/19. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — EYW
Nov 29 — Dec 61
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Key West with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Key West
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Best
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One-way
Cheapest flights from Panama City to Key WestExplore the most affordable flight options available from Panama City to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from Panama City to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:00 am -
1 stop3h 48m
Wed 11/256:08 pm -
1 stop6h 16m
Deal found 10/26![Delta logo]()
$532
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:00 am -
1 stop3h 48m
Thu 11/196:08 pm -
1 stop6h 16m
Deal found 10/26![Delta logo]()
$552
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1612:00 pm -
1 stop4h 56m
Wed 11/185:50 pm -
1 stop6h 02m
Deal found 10/26![American Airlines logo]()
$625
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/279:19 am -
1 stop6h 56m
Mon 11/22:00 pm -
1 stop6h 53m
Deal found 10/27![Delta logo]()
$663
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:00 am -
1 stop3h 48m
Sat 11/147:30 am -
1 stop6h 12m
Deal found 10/26![Delta logo]()
$683
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:10 am -
1 stop7h 52m
Thu 11/194:53 pm -
1 stop7h 54m
Deal found 10/26![American Airlines logo]()
$686
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:05 am -
2 stops7h 53m
Mon 11/23:41 pm -
1 stop8h 11m
Deal found 10/27![American Airlines logo]()
$697
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:25 am -
1 stop7h 39m
Wed 11/254:43 pm -
2 stops8h 04m
Deal found 10/26![American Airlines logo]()
$736
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:15 am -
1 stop4h 44m
Mon 11/167:30 am -
1 stop6h 12m
Deal found 10/27![Delta logo]()
$779
Best flights from Panama City to Key WestDiscover carefully curated flight deals from Panama City to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from Panama City to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:00 am -
1 stop3h 48m
Wed 11/256:08 pm -
1 stop6h 16m
Deal found 10/26![Delta logo]()
$532
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/112:02 pm -
1 stop4h 52m
Sat 2/69:58 am -
2 stops8h 28m
Deal found 10/29![American Airlines logo]()
$625
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:00 am -
1 stop3h 48m
Thu 11/196:08 pm -
1 stop6h 16m
Deal found 10/26![Delta logo]()
$552
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/11:57 pm -
1 stop5h 51m
Sat 2/67:30 am -
1 stop6h 54m
Deal found 10/29![Delta logo]()
$643
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:25 am -
1 stop7h 39m
Wed 11/254:43 pm -
2 stops8h 04m
Deal found 10/26![American Airlines logo]()
$736
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/168:19 am -
2 stops9h 43m
Wed 11/183:41 pm -
1 stop8h 11m
Deal found 10/26![American Airlines logo]()
$740
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:00 am -
1 stop3h 48m
Sat 11/147:30 am -
1 stop6h 12m
Deal found 10/26![Delta logo]()
$683
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:15 am -
1 stop4h 44m
Mon 11/167:30 am -
1 stop6h 12m
Deal found 10/27![Delta logo]()
$779
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/812:02 pm -
2 stops22h 00m
Sun 1/107:50 pm -
2 stops22h 36m
Deal found 10/29![American Airlines logo]()
$868
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/82:40 pm -
1 stop5h 09m
Sun 1/1011:48 am -
1 stop4h 37m
Deal found 10/29![Delta logo]()
$783
Last-minute flights from Panama City to Key WestDiscover last-minute flight deals from Panama City to Key West. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Key West. Data last updated October 30, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:00 am -
1 stop3h 48m
Sat 11/147:30 am -
1 stop6h 12m
Deal found 10/26![Delta logo]()
$683
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:00 am -
1 stop3h 48m
Thu 11/196:08 pm -
1 stop6h 16m
Deal found 10/26![Delta logo]()
$552
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:10 am -
1 stop7h 52m
Thu 11/194:53 pm -
1 stop7h 54m
Deal found 10/26![American Airlines logo]()
$686
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:15 am -
1 stop4h 44m
Mon 11/167:30 am -
1 stop6h 12m
Deal found 10/27![Delta logo]()
$779
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1612:00 pm -
1 stop4h 56m
Wed 11/185:50 pm -
1 stop6h 02m
Deal found 10/26![American Airlines logo]()
$625
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:00 am -
1 stop3h 48m
Wed 11/256:08 pm -
1 stop6h 16m
Deal found 10/26![Delta logo]()
$532
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:25 am -
1 stop7h 39m
Wed 11/254:43 pm -
2 stops8h 04m
Deal found 10/26![American Airlines logo]()
$736
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/247:25 am -
2 stops11h 51m
Sat 11/287:16 pm -
1 stop5h 31m
Deal found 10/25![American Airlines logo]()
$791
One-way flights from Panama City to Key WestSearch for one-way flight options from Panama City to Key West. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
Search for one-way flight options from Panama City to Key West. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/199:23 am -
1 stop7h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Delta logo]()
$443
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/192:58 pm -
2 stops25h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![United Airlines logo]()
$491
Find flight deals from Panama City to Key West
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $532 (Delta) |
One-way from | $443 (Delta) |
Popular in | September |
Cheapest in | February |
Average price | $446 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from Panama City to Key West that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Panama CityKey West
ECP Panama City NW Florida Beaches - EYW Key West
ECPEYW
Panama City NW Florida Beaches
Sat 12/19
9:23 am-5:23 pm
1 stop7h 00m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$443
Panama CityKey West
ECP Panama City NW Florida Beaches - EYW Key West
ECPEYW
Panama City NW Florida Beaches
Sat 12/19
2:58 pm-5:11 pm
2 stops25h 13m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$491
Panama CityKey West
ECP Panama City NW Florida Beaches - EYW Key West
ECPEYW
Panama City NW Florida Beaches
Sun 11/22
6:00 am-10:48 am
1 stop3h 48m
Key West
Wed 11/25
6:08 pm-11:24 pm
1 stop6h 16m
$532
Panama CityKey West
ECP Panama City NW Florida Beaches - EYW Key West
ECPEYW
Panama City NW Florida Beaches
Thu 11/12
6:00 am-10:48 am
1 stop3h 48m
Key West
Thu 11/19
6:08 pm-11:24 pm
1 stop6h 16m
$552
Panama CityKey West
ECP Panama City NW Florida Beaches - EYW Key West
ECPEYW
Panama City NW Florida Beaches
Mon 2/1
12:02 pm-5:54 pm
1 stop4h 52m
Key West
Sat 2/6
9:58 am-5:26 pm
2 stops8h 28m
$625
Panama CityKey West
ECP Panama City NW Florida Beaches - EYW Key West
ECPEYW
Panama City NW Florida Beaches
Mon 2/1
1:57 pm-8:48 pm
1 stop5h 51m
Key West
Sat 2/6
7:30 am-1:24 pm
1 stop6h 54m
$643
Panama CityKey West
ECP Panama City NW Florida Beaches - EYW Key West
ECPEYW
Panama City NW Florida Beaches
Tue 11/10
6:00 am-10:48 am
1 stop3h 48m
Key West
Sat 11/14
7:30 am-12:42 pm
1 stop6h 12m
$683
Panama CityKey West
ECP Panama City NW Florida Beaches - EYW Key West
ECPEYW
Panama City NW Florida Beaches
Sun 11/22
7:25 am-4:04 pm
1 stop7h 39m
Key West
Wed 11/25
4:43 pm-11:47 pm
2 stops8h 04m
$736
Panama CityKey West
ECP Panama City NW Florida Beaches - EYW Key West
ECPEYW
Panama City NW Florida Beaches
Mon 11/16
8:19 am-7:02 pm
2 stops9h 43m
Key West
Wed 11/18
3:41 pm-10:52 pm
1 stop8h 11m
$740
Panama CityKey West
ECP Panama City NW Florida Beaches - EYW Key West
ECPEYW
Panama City NW Florida Beaches
Thu 11/12
7:15 am-12:59 pm
1 stop4h 44m
Key West
Mon 11/16
7:30 am-12:42 pm
1 stop6h 12m
$779
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Panama City to Key West
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Key West in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Key West flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Key West flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Panama City with our price prediction graph.
ECP-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Key West
What is the cheapest month to book a flight from Panama City, Florida to Key West?
Currently, February is the cheapest month in which you can book a flight from Panama City, Florida to Key West (average of $332). Flying from Panama City, Florida to Key West in September is currently the most expensive (average of $678). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Panama City, Florida to Key West?
Airfare is typical for this route at the moment.
Panama City, Florida to Key West flights typically cost between $383 and $577 in November.The cheapest round-trip price found within the last 5 days was $532 on Delta (Nov 22-Nov 25).
Reviews of airlines servicing Key West
Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated October 30, 2026.
Read through reviews of airlines operating flights from Panama City to Key West, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Crew
8.5
Comfort
7.8
Entertainment
7.8
Overall
7.8
Boarding
8.1
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Food
7.2
Crew
8.5
Comfort
7.8
Entertainment
7.8
Overall
7.8
Boarding
8.1
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Related info for your journey
Find useful and relevant information for your journey from Panama City to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Other flights to Key West
Explore flights to Key West departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Panama City and Key West flights
Browse other Panama City and Key West flight options. Last updated on October 30, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Panama City to Key West
Discover the top airline that operate flights from Panama City to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$340 | Average$452 | FlexibilityNo cancel fee | On-timeN/A |