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Panama City

$427+ Cheap flights from Key West to Panama City, FL (EYW - ECP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/28. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — ECP
May 17 — May 241
Sun 5/17
Sun 5/24
1 adult, Economy
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Cheap flight deals from Key West to Panama City

Cheapest flights from Key West to Panama City
Explore the most affordable flight options available from Key West to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2026.

This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:25 pm
EYW
-
ECP
1 stop6h 27m
American Airlines
Sat 5/24:40 pm
ECP
-
EYW
1 stop4h 56m
American Airlines
Deal found 4/13$427
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:23 pm
EYW
-
ECP
1 stop5h 49m
Delta
Sun 4/265:49 am
ECP
-
EYW
1 stop3h 57m
Delta
Deal found 4/17$567
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:23 pm
EYW
-
ECP
1 stop5h 49m
Delta
Fri 5/17:05 am
ECP
-
EYW
1 stop5h 39m
Delta
Deal found 4/13$635
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:45 am
EYW
-
ECP
2 stops10h 18m
American Airlines
Thu 4/304:40 pm
ECP
-
EYW
1 stop4h 56m
American Airlines
Deal found 4/13$640
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:58 pm
EYW
-
ECP
2 stops7h 54m
American Airlines
Fri 5/112:18 pm
ECP
-
EYW
2 stops9h 40m
American Airlines
Deal found 4/13$645
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/207:33 am
EYW
-
ECP
1 stop6h 08m
Delta
Thu 4/237:05 am
ECP
-
EYW
1 stop5h 39m
Delta
Deal found 4/14$835
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/203:58 pm
EYW
-
ECP
2 stops8h 48m
American Airlines
Thu 4/234:40 pm
ECP
-
EYW
1 stop4h 56m
American Airlines
Deal found 4/14$840
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/284:38 pm
EYW
-
ECP
3 stops21h 45m
United Airlines
Sat 5/23:35 pm
ECP
-
EYW
2 stops22h 32m
United Airlines
Deal found 4/13$1,024

Find flight deals from Key West to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 17, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$427
(American Airlines)
Provider with most accurate pricing for Key West-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Panama City NW Florida Beaches flights.
Search Deals
From Key West to Panama City NW Florida Beaches
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2026.
Use the filters below to find and compare flights from Key West to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Key WestPanama City

EYW - ECP

EYWECP

Key West

Tue 4/28

3:58 pm-10:52 pm

2 stops7h 54m

Panama City NW Florida Beaches

Sat 5/2

4:40 pm-10:36 pm

1 stop4h 56m

$432

Key WestPanama City

EYW - ECP

EYWECP

Key West

Tue 4/28

6:23 pm-11:12 pm

1 stop5h 49m

Panama City NW Florida Beaches

Fri 5/1

7:05 am-1:44 pm

1 stop5h 39m

$635
Quickest round-trip

Key WestPanama City

EYW - ECP

EYWECP

Key West

Mon 4/27

2:40 pm-7:36 pm

1 stop5h 56m

Panama City NW Florida Beaches

Thu 4/30

5:49 am-10:46 am

1 stop3h 57m

$635

Key WestPanama City

EYW - ECP

EYWECP

Key West

Mon 4/27

6:45 am-4:03 pm

2 stops10h 18m

Panama City NW Florida Beaches

Thu 4/30

4:40 pm-10:36 pm

1 stop4h 56m

$640

Key WestPanama City

EYW - ECP

EYWECP

Key West

Tue 4/28

4:38 pm-1:23 pm

3 stops21h 45m

Panama City NW Florida Beaches

Sat 5/2

3:35 pm-3:07 pm

2 stops22h 32m

$1,024

Key WestPanama City

EYW - ECP

EYWECP

Key West

Mon 4/27

6:22 pm-1:23 pm

3 stops20h 01m

Panama City NW Florida Beaches

Thu 4/30

11:20 am-3:07 pm

2 stops26h 47m

$1,209

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/13

Sorted by cheapest first

Compare providers for flights from Key West to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to Panama City in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Key West-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Key West-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Key West-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Key West-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Key West to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to Panama City, Florida?

    American Airlines, Delta, and United Airlines can get you from Key West to Panama City, Florida in just under 5h 49m. Your travel time can differ by up to 15h 56m. The distance between Key West and Panama City, Florida is about 471 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Key West to Panama City that include hotel bookings?

    Yes. In addition to deals on Key West to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to Panama City.

  • Can I find deals for business class flights from Key West to Panama City?

    Yes. Cheapflights offers flight deals from Key West to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

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