HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Key West

$140+ Cheap flights from Missouri to Key West (EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to Key West with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to Key West

Keep the following information in mind while searching for Missouri to Key West flight deals. Data was last updated July 31, 2025.

Round-trip from

$223
(Delta)

One-way from

$140
(Delta)

Popular in

May

Cheapest in

September

Average price

$348
From Missouri to Key West
Search Deals
One-way flight from Missouri to Key West
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($38 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Missouri to Key West

Cheapest flights from Missouri to Key West
Explore the most affordable flight options available from Missouri to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1310:15 amSTL - EYW
1 stop6h 00mDelta
Tue 9/167:00 amEYW - STL
1 stop6h 21mDelta
Deal found 7/29$223
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/228:49 amSTL - EYW
2 stops9h 33mAmerican Airlines
Tue 10/281:38 pmEYW - STL
1 stop8h 48mAmerican Airlines
Deal found 7/31$228
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/118:17 amSGF - EYW
1 stop8h 34mAmerican Airlines
Sat 11/154:26 pmEYW - SGF
1 stop6h 48mAmerican Airlines
Deal found 7/29$259
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/49:45 amMCI - EYW
1 stop5h 31mAmerican Airlines
Sat 11/88:00 pmEYW - MCI
1 stop4h 59mAmerican Airlines
Deal found 7/29$283
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/116:00 amSGF - EYW
1 stop6h 08mDelta
Sat 11/156:00 pmEYW - SGF
1 stop5h 32mDelta
Deal found 7/31$299
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2712:11 pmMCI - EYW
1 stop7h 01mDelta
Wed 9/37:00 amEYW - MCI
1 stop5h 06mDelta
Deal found 7/30$306
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:00 amMCI - EYW
1 stop8h 09mUnited Airlines
Wed 12/173:02 pmEYW - MCI
1 stop9h 42mUnited Airlines
Deal found 7/30$349
This Mytrip deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/16:00 amMCI - EYW
1 stop6h 07mMultiple Airlines
Fri 9/58:47 amEYW - MCI
1 stop15h 20mMultiple Airlines
Deal found 7/30$386
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:00 amMCI - EYW
3 stops29h 30mSpirit Airlines
Sun 11/162:25 pmEYW - MCI
3 stops35h 15mSpirit Airlines
Deal found 7/29$487
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/238:05 amJLN - EYW
2 stops28h 56mUnited Airlines
Tue 8/263:41 pmEYW - JLN
2 stops33h 02mUnited Airlines
Deal found 7/29$858
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/113:20 pmSGF - EYW
2 stops21h 49mUnited Airlines
Sat 11/153:05 pmEYW - SGF
3 stops20h 46mUnited Airlines
Deal found 7/29$880

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Missouri to Key West that are best for you.

Fly from

Missouri

Fly to

Key West

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 9/13

10:15 am-5:15 pm

1 stop6h 00m

Key West

Tue 9/16

7:00 am-12:21 pm

1 stop6h 21m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 10/22

8:49 am-7:22 pm

2 stops9h 33m

Key West

Tue 10/28

1:38 pm-9:26 pm

1 stop8h 48m

$228

SpringfieldKey West

SGF - EYW

SGFEYW

Springfield-Branson

Fri 8/15

9:15 am-4:22 pm

1 stop6h 07m

Key West

Tue 8/19

11:26 am-9:25 pm

2 stops10h 59m

$294

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Wed 8/27

12:11 pm-8:12 pm

1 stop7h 01m

Key West

Wed 9/3

7:00 am-11:06 am

1 stop5h 06m

$306

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Wed 8/27

6:00 am-7:07 pm

2 stops12h 07m

Key West

Wed 9/3

7:31 pm-11:59 pm

1 stop5h 28m

$312

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Mon 9/1

6:00 am-1:07 pm

1 stop6h 07m

Key West

Fri 9/5

8:47 am-11:07 pm

1 stop15h 20m

$386

SpringfieldKey West

SGF - EYW

SGFEYW

Springfield-Branson

Thu 8/14

11:38 am-8:12 pm

1 stop7h 34m

Key West

Mon 8/18

2:00 pm-5:53 pm

1 stop4h 53m

$588

JoplinKey West

JLN - EYW

JLNEYW

Joplin

Sat 8/23

8:05 am-2:01 pm

2 stops28h 56m

Key West

Tue 8/26

3:41 pm-11:43 pm

2 stops33h 02m

$858

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 10/15

1:30 pm-8:06 pm

1 stop5h 36m

$140

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Fri 8/8

6:16 am-12:32 pm

1 stop5h 16m

$239

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Showing 1-10 of 13 results
1
2

Best time to book a flight from Missouri to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Key West

What is the cheapest month to book a flight from Missouri to Key West?

Currently, August is the cheapest month in which you can book a flight from Missouri to Key West (average of $328). Flying from Missouri to Key West in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to EYW?

Find hourly flight availability from Missouri to Key West. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

When flying from Missouri to Key West, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated July 31, 2025.
Read through reviews of airlines operating flights from Missouri to Key West, such as Delta, United Airlines, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Mark,Jun 2024

SGF - ATL

One of the worst flights ever. I got to the airport early for my 6:48 pm flight and tried to get on the 4:30 ish flight. The gate agent was one of the worst customer service people in my 20 yrs of flying Delta. Very rude and wouldn’t even talk to me about riding standby. Then flight took off 3 hrs late and when Landed in Atlanta, the gate people wouldn’t even try to get me on the plane. It was still there but door was closed. For all of my almost 2 million miles, the worst experience from Delta. I am highly disappointed as it was not my fault I have to sleep in Atlanta and not Jacksonville Florida
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Mark,Jun 2024

SGF - ATL

One of the worst flights ever. I got to the airport early for my 6:48 pm flight and tried to get on the 4:30 ish flight. The gate agent was one of the worst customer service people in my 20 yrs of flying Delta. Very rude and wouldn’t even talk to me about riding standby. Then flight took off 3 hrs late and when Landed in Atlanta, the gate people wouldn’t even try to get me on the plane. It was still there but door was closed. For all of my almost 2 million miles, the worst experience from Delta. I am highly disappointed as it was not my fault I have to sleep in Atlanta and not Jacksonville Florida
United Airlines
7.4
Good
8,900 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Mark,Jun 2024

SGF - ATL

One of the worst flights ever. I got to the airport early for my 6:48 pm flight and tried to get on the 4:30 ish flight. The gate agent was one of the worst customer service people in my 20 yrs of flying Delta. Very rude and wouldn’t even talk to me about riding standby. Then flight took off 3 hrs late and when Landed in Atlanta, the gate people wouldn’t even try to get me on the plane. It was still there but door was closed. For all of my almost 2 million miles, the worst experience from Delta. I am highly disappointed as it was not my fault I have to sleep in Atlanta and not Jacksonville Florida
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Mark,Jun 2024

SGF - ATL

One of the worst flights ever. I got to the airport early for my 6:48 pm flight and tried to get on the 4:30 ish flight. The gate agent was one of the worst customer service people in my 20 yrs of flying Delta. Very rude and wouldn’t even talk to me about riding standby. Then flight took off 3 hrs late and when Landed in Atlanta, the gate people wouldn’t even try to get me on the plane. It was still there but door was closed. For all of my almost 2 million miles, the worst experience from Delta. I am highly disappointed as it was not my fault I have to sleep in Atlanta and not Jacksonville Florida
Allegiant Air
7.2
Good
702 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Mark,Jun 2024

SGF - ATL

One of the worst flights ever. I got to the airport early for my 6:48 pm flight and tried to get on the 4:30 ish flight. The gate agent was one of the worst customer service people in my 20 yrs of flying Delta. Very rude and wouldn’t even talk to me about riding standby. Then flight took off 3 hrs late and when Landed in Atlanta, the gate people wouldn’t even try to get me on the plane. It was still there but door was closed. For all of my almost 2 million miles, the worst experience from Delta. I am highly disappointed as it was not my fault I have to sleep in Atlanta and not Jacksonville Florida

Related info for your journey

Find useful and relevant information for your journey from Missouri to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from Missouri?

    Key West (EYW) is the airport you will fly into if you book a flight from Missouri to Key West. It is only a 2.6 mi journey from Key West (EYW) to Key West’s city center.

  • What are the cheapest airlines to fly from Missouri to Key West one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $140. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Missouri to Key West for a low price.

  • What are the most popular routes from Missouri to Key West?

    When deciding which route to take from Missouri to Key West consider Lambert-St Louis - Key West, Kansas City - Key West or Springfield-Branson - Key West as they are the most popular.

  • Can I find deals for flights from Missouri to Key West that include hotel bookings?

    Yes. In addition to deals on Missouri to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Key West.

  • Can I find deals for business class flights from Missouri to Key West?

    Yes. Cheapflights offers flight deals from Missouri to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Key West?

    Currently, August is the cheapest month in which you can book a flight from Missouri to Key West (average of $328). Flying from Missouri to Key West in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Key West

See prices for flight routes from nearby airports that may be better suited for you.
Newark to Fort Lauderdale flights
LaGuardia to Fort Lauderdale flights
John F Kennedy Intl to Orlando flights
John F Kennedy Intl to Miami flights
Newark to Orlando flights
Newark to Miami flights
LaGuardia to Miami flights
John F Kennedy Intl to Fort Lauderdale flights
LaGuardia to Orlando flights
Dulles Intl to Miami flights
John F Kennedy Intl to West Palm Beach flights
Baltimore to Fort Lauderdale flights
Philadelphia to Orlando flights
Los Angeles to Miami flights
Los Angeles to Orlando flights
Newark to Tampa flights
Dallas/Fort Worth to Miami flights
Dallas/Fort Worth to Orlando flights
Philadelphia to Fort Lauderdale flights
Atlanta to Miami flights
O'Hare Intl to Orlando flights
John F Kennedy Intl to Tampa flights
Boston to Orlando flights
Atlanta to Fort Lauderdale flights
Baltimore to Miami flights
Boston to Fort Lauderdale flights
Reagan-National to Miami flights
Hartford to Orlando flights
Los Angeles to Fort Lauderdale flights
O'Hare Intl to Fort Lauderdale flights
Baltimore to Orlando flights
Dulles Intl to Orlando flights
Denver to Orlando flights
Dallas/Fort Worth to Fort Lauderdale flights
O'Hare Intl to Miami flights
Minneapolis to Orlando flights
Cleveland to Orlando flights
White Plains to Orlando flights
Dulles Intl to Fort Lauderdale flights
Boston to Miami flights
LaGuardia to West Palm Beach flights
LaGuardia to Tampa flights
Newark to West Palm Beach flights
Reagan-National to Orlando flights
Philadelphia to Miami flights
Reagan-National to Fort Lauderdale flights
Detroit to Orlando flights
Cincinnati to Orlando flights
Dulles Intl to Tampa flights
Providence to Orlando flights

Top 3 airlines flying from Missouri to Key West

Discover the top 3 airlines that operate flights from Missouri to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$189Average$391FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$213Average$449FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$245Average$487FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.