$122+ Cheap flights from Missouri to Key West (EYW)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
Mar 3 — Mar 101
1 adult, Economy
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Find cheap flights from Missouri to Key West with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Key West
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Cheapest flights from Missouri to Key WestExplore the most affordable flight options available from Missouri to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 1, 2026.
Explore the most affordable flight options available from Missouri to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 1, 2026.
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/42:06 pm
STL
- EYW
1 stop7h 16m
American Airlines
Tue 3/107:42 pm
EYW
- STL
1 stop5h 16m
American Airlines
Deal found 1/30![American Airlines logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:26 am
MCI
- EYW
1 stop25h 04m
Spirit Airlines
Thu 3/52:25 pm
EYW
- MCI
1 stop21h 05m
Spirit Airlines
Deal found 1/31![Spirit Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/74:21 pm
STL
- EYW
1 stop14h 45m
Multiple Airlines
Wed 3/1111:51 am
EYW
- STL
1 stop12h 28m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$239
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/51:34 pm
STL
- EYW
1 stop8h 03m
American Airlines
Tue 3/108:04 am
EYW
- STL
1 stop6h 12m
American Airlines
Deal found 1/29![American Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/98:12 pm
STL
- EYW
2 stops15h 09m
Multiple Airlines
Thu 3/129:46 am
EYW
- STL
1 stop22h 36m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:26 am
MCI
- EYW
2 stops24h 00m
Multiple Airlines
Thu 3/52:25 pm
EYW
- MCI
1 stop21h 05m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/85:42 pm
STL
- EYW
1 stop17h 44m
Multiple Airlines
Thu 2/129:46 am
EYW
- STL
1 stop15h 13m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/43:49 pm
STL
- EYW
1 stop16h 17m
Multiple Airlines
Tue 3/101:01 pm
EYW
- STL
2 stops22h 36m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/43:49 pm
STL
- EYW
1 stop16h 17m
Multiple Airlines
Sun 3/89:46 am
EYW
- STL
2 stops28h 33m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$264
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:04 pm
STL
- EYW
1 stop4h 26m
Delta
Wed 4/17:30 am
EYW
- STL
1 stop4h 39m
Delta
Deal found 1/31![Delta logo]()
$266
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:06 am
STL
- EYW
1 stop8h 15m
American Airlines
Mon 3/97:42 pm
EYW
- STL
1 stop5h 16m
American Airlines
Deal found 1/31![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:26 am
MCI
- EYW
1 stop25h 04m
Multiple Airlines
Sun 3/14:13 pm
EYW
- MCI
1 stop24h 16m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$279
Best flights from Missouri to Key WestDiscover carefully curated flight deals from Missouri to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 1, 2026.
Discover carefully curated flight deals from Missouri to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 1, 2026.
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2512:04 pm
STL
- EYW
1 stop6h 37m
Delta
Tue 4/76:25 pm
EYW
- STL
1 stop6h 33m
Delta
Deal found 1/31![Delta logo]()
$223
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/42:06 pm
STL
- EYW
1 stop7h 16m
American Airlines
Tue 3/107:42 pm
EYW
- STL
1 stop5h 16m
American Airlines
Deal found 1/30![American Airlines logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:26 am
MCI
- EYW
1 stop25h 04m
Spirit Airlines
Thu 3/52:25 pm
EYW
- MCI
1 stop21h 05m
Spirit Airlines
Deal found 1/31![Spirit Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/98:12 pm
STL
- EYW
2 stops15h 09m
Multiple Airlines
Thu 3/129:46 am
EYW
- STL
1 stop22h 36m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$253
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:00 am
SGF
- EYW
1 stop8h 53m
United Airlines
Wed 2/183:56 pm
EYW
- SGF
1 stop7h 03m
United Airlines
Deal found 1/30![United Airlines logo]()
$360
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2512:04 pm
STL
- EYW
1 stop6h 37m
Delta
Thu 4/27:30 am
EYW
- STL
1 stop4h 39m
Delta
Deal found 1/31![Delta logo]()
$251
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:04 pm
STL
- EYW
1 stop4h 26m
Delta
Thu 4/27:30 am
EYW
- STL
1 stop4h 39m
Delta
Deal found 1/31![Delta logo]()
$251
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:06 am
STL
- EYW
1 stop8h 15m
American Airlines
Mon 3/97:42 pm
EYW
- STL
1 stop5h 16m
American Airlines
Deal found 1/31![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/183:49 pm
STL
- EYW
1 stop16h 17m
Multiple Airlines
Tue 2/241:01 pm
EYW
- STL
2 stops18h 50m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1912:24 pm
MCI
- EYW
1 stop24h 13m
Spirit Airlines
Fri 3/272:35 pm
EYW
- MCI
1 stop21h 54m
Spirit Airlines
Deal found 1/30![Spirit Airlines logo]()
$303
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:04 pm
STL
- EYW
1 stop4h 26m
Delta
Wed 4/17:30 am
EYW
- STL
1 stop4h 39m
Delta
Deal found 1/31![Delta logo]()
$266
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1811:22 am
STL
- EYW
1 stop6h 53m
American Airlines
Tue 2/247:45 pm
EYW
- STL
1 stop5h 11m
American Airlines
Deal found 1/30![American Airlines logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/53:49 pm
STL
- EYW
1 stop19h 37m
Multiple Airlines
Tue 3/101:01 pm
EYW
- STL
2 stops22h 36m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/1511:26 am
MCI
- EYW
1 stop25h 04m
Spirit Airlines
Thu 2/192:25 pm
EYW
- MCI
1 stop21h 05m
Spirit Airlines
Deal found 1/30![Spirit Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/268:54 am
MCI
- EYW
1 stop11h 49m
Multiple Airlines
Sun 3/2912:25 pm
EYW
- MCI
2 stops12h 28m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$316
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/253:36 pm
SGF
- EYW
1 stop6h 00m
American Airlines
Wed 4/294:20 pm
EYW
- SGF
1 stop6h 34m
American Airlines
Deal found 1/30![American Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2512:04 pm
STL
- EYW
1 stop6h 37m
Delta
Sat 4/46:25 pm
EYW
- STL
1 stop6h 33m
Delta
Deal found 1/31![Delta logo]()
$326
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:52 am
STL
- EYW
1 stop27h 34m
Multiple Airlines
Sun 3/159:46 am
EYW
- STL
1 stop22h 16m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$328
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1410:32 am
SGF
- EYW
1 stop6h 47m
American Airlines
Wed 2/181:55 pm
EYW
- SGF
2 stops9h 40m
American Airlines
Deal found 1/30![American Airlines logo]()
$354
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/213:15 pm
SGF
- EYW
1 stop5h 54m
United Airlines
Mon 2/236:40 pm
EYW
- SGF
2 stops28h 19m
United Airlines
Deal found 1/31![United Airlines logo]()
$477
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1110:30 am
MCI
- EYW
1 stop6h 00m
Delta
Sat 4/187:33 am
EYW
- MCI
1 stop6h 28m
Delta
Deal found 1/31![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/107:00 am
MCI
- EYW
1 stop6h 18m
American Airlines
Sun 2/155:04 pm
EYW
- MCI
1 stop7h 29m
American Airlines
Deal found 1/30![American Airlines logo]()
$364
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/201:23 pm
MCI
- EYW
1 stop5h 19m
Delta
Wed 2/255:56 pm
EYW
- MCI
1 stop6h 44m
Delta
Deal found 1/31![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1712:25 pm
MCI
- EYW
1 stop6h 15m
Delta
Fri 4/246:19 pm
EYW
- MCI
1 stop6h 31m
Delta
Deal found 1/30![Delta logo]()
$341
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/101:22 pm
MCI
- EYW
1 stop5h 18m
Delta
Sun 2/155:56 pm
EYW
- MCI
1 stop6h 44m
Delta
Deal found 1/31![Delta logo]()
$364
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2410:54 am
SGF
- EYW
1 stop5h 08m
American Airlines
Tue 4/288:20 am
EYW
- SGF
1 stop7h 27m
American Airlines
Deal found 1/30![American Airlines logo]()
$456
This Delta deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/271:23 pm
MCI
- EYW
1 stop5h 19m
Delta
Fri 3/65:56 pm
EYW
- MCI
1 stop6h 44m
Delta
Deal found 1/30![Delta logo]()
$366
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:54 am
SGF
- EYW
1 stop5h 08m
American Airlines
Tue 5/58:20 am
EYW
- SGF
1 stop7h 27m
American Airlines
Deal found 1/30![American Airlines logo]()
$489
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:00 am
SGF
- EYW
2 stops8h 40m
American Airlines
Wed 4/291:36 pm
EYW
- SGF
2 stops9h 18m
American Airlines
Deal found 1/30![American Airlines logo]()
$499
Last-minute flights from Missouri to Key WestDiscover last-minute flight deals from Missouri to Key West. Data last updated February 1, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Key West. Data last updated February 1, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3110:17 am
STL
- EYW
1 stop6h 49m
American Airlines
Sat 2/72:04 pm
EYW
- STL
1 stop9h 40m
American Airlines
Deal found 1/30![American Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/85:42 pm
STL
- EYW
1 stop17h 44m
Multiple Airlines
Thu 2/129:46 am
EYW
- STL
1 stop15h 13m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$255
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1410:32 am
SGF
- EYW
1 stop6h 47m
American Airlines
Wed 2/181:55 pm
EYW
- SGF
2 stops9h 40m
American Airlines
Deal found 1/30![American Airlines logo]()
$354
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/1511:26 am
MCI
- EYW
1 stop25h 04m
Multiple Airlines
Thu 2/199:46 am
EYW
- MCI
2 stops25h 44m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/1511:26 am
MCI
- EYW
1 stop25h 04m
Spirit Airlines
Thu 2/192:25 pm
EYW
- MCI
1 stop21h 05m
Spirit Airlines
Deal found 1/30![Spirit Airlines logo]()
$303
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/177:05 am
STL
- EYW
1 stop6h 35m
American Airlines
Tue 2/241:55 pm
EYW
- STL
2 stops10h 53m
American Airlines
Deal found 1/30![American Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/183:49 pm
STL
- EYW
1 stop16h 17m
Multiple Airlines
Tue 2/241:01 pm
EYW
- STL
2 stops18h 50m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$282
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/187:00 am
STL
- EYW
1 stop8h 24m
American Airlines
Tue 2/247:45 pm
EYW
- STL
1 stop5h 11m
American Airlines
Deal found 1/30![American Airlines logo]()
$294
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/201:23 pm
MCI
- EYW
1 stop5h 19m
Delta
Wed 2/255:56 pm
EYW
- MCI
1 stop6h 44m
Delta
Deal found 1/31![Delta logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:26 am
MCI
- EYW
1 stop25h 04m
Spirit Airlines
Thu 3/52:25 pm
EYW
- MCI
1 stop21h 05m
Spirit Airlines
Deal found 1/31![Spirit Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:26 am
MCI
- EYW
2 stops24h 00m
Multiple Airlines
Thu 3/52:25 pm
EYW
- MCI
1 stop21h 05m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:26 am
MCI
- EYW
1 stop25h 04m
Multiple Airlines
Sun 3/14:13 pm
EYW
- MCI
1 stop24h 16m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$279
One-way flights from Missouri to Key WestSearch for one-way flight options from Missouri to Key West. Find affordable one-way fares based on user searches. Data last updated February 1, 2026.
Search for one-way flight options from Missouri to Key West. Find affordable one-way fares based on user searches. Data last updated February 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:26 am
MCI
- EYW
1 stop25h 04m
Spirit Airlines
Deal found 1/31![Spirit Airlines logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:26 am
MCI
- EYW
2 stops24h 00m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/288:41 pm
MCI
- EYW
2 stops11h 25m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$160
This Mytrip deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:00 am
MCI
- EYW
3 stops27h 17m
Spirit Airlines
Deal found 1/29![Spirit Airlines logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:00 am
MCI
- EYW
1 stop26h 06m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:16 am
SGF
- EYW
3 stops47h 05m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:23 pm
SGF
- EYW
2 stops35h 45m
Allegiant Air
Deal found 1/30![Allegiant Air logo]()
$278
This Delta deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:42 am
SGF
- EYW
1 stop4h 41m
Delta
Deal found 1/30![Delta logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/158:40 pm
MCI
- EYW
3 stops38h 41m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$287
This Delta deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2810:30 am
MCI
- EYW
1 stop5h 31m
Delta
Deal found 1/30![Delta logo]()
$305
Find flight deals from Missouri to Key West
Keep the following information in mind while searching for Missouri to Key West flight deals. Data was last updated February 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $223 (American Airlines) |
One-way from | $122 (Kiwi.com) |
Popular in | March |
Cheapest in | December |
Average price | $398 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 1, 2026.
Use the filters below to find and compare flights from Missouri to Key West that are best for you.
Fly from
Missouri
Fly to
Key West
Route
Depart
Return
Price
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Wed 3/25
12:04 pm-7:41 pm
1 stop6h 37m
Key West
Tue 4/7
6:25 pm-11:58 pm
1 stop6h 33m
$223
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Wed 3/4
2:06 pm-10:22 pm
1 stop7h 16m
Key West
Tue 3/10
7:42 pm-11:58 pm
1 stop5h 16m
$223
Kansas CityKey West
MCI - EYW
MCIEYW
Kansas City
Thu 2/26
11:26 am-1:30 pm
1 stop25h 04m
Key West
Thu 3/5
2:25 pm-10:30 am
1 stop21h 05m
$237
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Wed 3/25
12:04 pm-7:41 pm
1 stop6h 37m
Key West
Thu 4/2
7:30 am-11:09 am
1 stop4h 39m
$251
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Tue 3/24
12:04 pm-5:30 pm
1 stop4h 26m
Key West
Thu 4/2
7:30 am-11:09 am
1 stop4h 39m
$251
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Mon 3/9
8:12 pm-12:21 pm
2 stops15h 09m
Key West
Thu 3/12
9:46 am-7:22 am
1 stop22h 36m
$253
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Tue 3/24
12:04 pm-5:30 pm
1 stop4h 26m
Key West
Wed 4/1
7:30 am-11:09 am
1 stop4h 39m
$266
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Mon 3/2
6:06 am-3:21 pm
1 stop8h 15m
Key West
Mon 3/9
7:42 pm-11:58 pm
1 stop5h 16m
$279
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Wed 2/18
3:49 pm-9:06 am
1 stop16h 17m
Key West
Tue 2/24
1:01 pm-6:51 am
2 stops18h 50m
$282
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Wed 2/18
11:22 am-7:15 pm
1 stop6h 53m
Key West
Tue 2/24
7:45 pm-11:56 pm
1 stop5h 11m
$294
Showing 1-10 of 38 results
Best time to book a flight from Missouri to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Missouri with our price prediction graph.
STL-EYW
MCI-EYW
SGF-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Key West
USMO-EYW
STL-EYW
MCI-EYW
SGF-EYW
What is the cheapest month to book a flight from Missouri to Key West?
Currently, April is the cheapest month in which you can book a flight from Missouri to Key West (average of $189). Flying from Missouri to Key West in August is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes for Missouri to Key West
See prices for flight routes from nearby airports that may be better suited for you.
Top 3 airlines flying from Missouri to Key West
Discover the top 3 airlines that operate flights from Missouri to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$189 | Average$425 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$222 | Average$490 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$245 | Average$432 | FlexibilityNo cancel fee | On-time69% |