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Key West

$223+ Cheap flights from Missouri to Key West (EYW)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/1. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Missouri to Key West

Keep the following information in mind while searching for Missouri to Key West flight deals. Data was last updated May 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$223
(Delta)

Popular in

May

Cheapest in

August

Average price

$530
Provider with most accurate pricing for Kansas City-Key West flight deals.
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Provider most trusted by Cheapflights users for Kansas City-Key West flights.
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From Missouri to Key West
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($82 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from Missouri to Key West

Cheapest flights from Missouri to Key West
Explore the most affordable flight options available from Missouri to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/111:51 amSTL - EYW
1 stop6h 53mDelta
Tue 10/72:35 pmEYW - STL
1 stop4h 27mDelta
Deal found 4/30$223
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:00 amSTL - EYW
2 stops7h 40mAmerican Airlines
Tue 10/75:16 pmEYW - STL
1 stop7h 13mAmerican Airlines
Deal found 4/30$228
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/167:00 amSGF - EYW
1 stop7h 19mAmerican Airlines
Sat 8/2312:50 pmEYW - SGF
1 stop5h 55mAmerican Airlines
Deal found 4/29$259
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/51:13 pmMCI - EYW
1 stop5h 26mDelta
Wed 7/96:27 pmEYW - MCI
1 stop6h 32mDelta
Deal found 4/30$269
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/95:12 amMCI - EYW
1 stop5h 00mAmerican Airlines
Tue 9/163:01 pmEYW - MCI
2 stops8h 19mAmerican Airlines
Deal found 5/1$274
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/148:25 amMCI - EYW
2 stops22h 35mUnited Airlines
Tue 6/172:12 pmEYW - MCI
1 stop8h 58mUnited Airlines
Deal found 4/30$374
This Mytrip deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/136:05 amMCI - EYW
1 stop6h 12mMultiple Airlines
Thu 6/198:53 amEYW - MCI
1 stop11h 18mMultiple Airlines
Deal found 5/1$378
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/13:20 pmSGF - EYW
2 stops20h 55mUnited Airlines
Wed 11/58:45 amEYW - SGF
2 stops13h 43mUnited Airlines
Deal found 5/1$425
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/248:25 amSTL - EYW
2 stops22h 35mUnited Airlines
Mon 6/306:45 pmEYW - STL
2 stops25h 08mUnited Airlines
Deal found 4/30$428
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/319:50 amSTL - EYW
3 stops23h 02mMultiple Airlines
Sat 6/73:53 pmEYW - STL
3 stops27h 48mMultiple Airlines
Deal found 4/30$429
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/157:59 amJLN - EYW
2 stops33h 06mUnited Airlines
Mon 5/198:45 amEYW - JLN
2 stops33h 13mUnited Airlines
Deal found 4/30$655

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Missouri to Key West that are best for you.

Fly from

Missouri

Fly to

Key West

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 10/1

11:51 am-7:44 pm

1 stop6h 53m

Key West

Tue 10/7

2:35 pm-6:02 pm

1 stop4h 27m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 10/1

6:00 am-2:40 pm

2 stops7h 40m

Key West

Tue 10/7

5:16 pm-11:29 pm

1 stop7h 13m

$228

SpringfieldKey West

SGF - EYW

SGFEYW

Springfield-Branson

Sat 8/16

7:00 am-3:19 pm

1 stop7h 19m

Key West

Sat 8/23

12:50 pm-5:45 pm

1 stop5h 55m

$259

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Sat 7/5

1:13 pm-7:39 pm

1 stop5h 26m

Key West

Wed 7/9

6:27 pm-11:59 pm

1 stop6h 32m

$269

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Tue 9/9

5:12 am-11:12 am

1 stop5h 00m

Key West

Tue 9/16

3:01 pm-10:20 pm

2 stops8h 19m

$274

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 5/31

10:10 am-9:52 am

2 stops22h 42m

Key West

Sat 6/7

3:53 pm-6:41 pm

3 stops27h 48m

$374

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Sat 6/14

8:25 am-8:00 am

2 stops22h 35m

Key West

Tue 6/17

2:12 pm-10:10 pm

1 stop8h 58m

$374

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Fri 6/13

6:05 am-1:17 pm

1 stop6h 12m

Key West

Thu 6/19

8:53 am-7:11 pm

1 stop11h 18m

$378

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 6/24

8:25 am-8:00 am

2 stops22h 35m

Key West

Mon 6/30

6:45 pm-6:53 pm

2 stops25h 08m

$428

JoplinKey West

JLN - EYW

JLNEYW

Joplin

Thu 5/15

7:59 am-6:05 pm

2 stops33h 06m

Key West

Mon 5/19

8:45 am-4:58 pm

2 stops33h 13m

$655

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 17 results
1
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Best time to book a flight from Missouri to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Key West

What is the cheapest month to book a flight from Missouri to Key West?

Currently, August is the cheapest month in which you can book a flight from Missouri to Key West (average of $328). Flying from Missouri to Key West in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to EYW?

Find hourly flight availability from Missouri to Key West. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

When flying from Missouri to Key West, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Key West by month

Plan your trip to Key West by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Key West ranges from 1.5 - 6.7 inches per month. September is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Key West when rainfall is around 1.5 in.

Temperature in Key West by month

Plan your trip to Key West by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Key West, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 69.8 F).

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated May 1, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and American Airlines from Missouri to Key West by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
2.0
Mediocre

Mark,Jun 2024

SGF - ATL

One of the worst flights ever. I got to the airport early for my 6:48 pm flight and tried to get on the 4:30 ish flight. The gate agent was one of the worst customer service people in my 20 yrs of flying Delta. Very rude and wouldn’t even talk to me about riding standby. Then flight took off 3 hrs late and when Landed in Atlanta, the gate people wouldn’t even try to get me on the plane. It was still there but door was closed. For all of my almost 2 million miles, the worst experience from Delta. I am highly disappointed as it was not my fault I have to sleep in Atlanta and not Jacksonville Florida
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
2.0
Mediocre

Mark,Jun 2024

SGF - ATL

One of the worst flights ever. I got to the airport early for my 6:48 pm flight and tried to get on the 4:30 ish flight. The gate agent was one of the worst customer service people in my 20 yrs of flying Delta. Very rude and wouldn’t even talk to me about riding standby. Then flight took off 3 hrs late and when Landed in Atlanta, the gate people wouldn’t even try to get me on the plane. It was still there but door was closed. For all of my almost 2 million miles, the worst experience from Delta. I am highly disappointed as it was not my fault I have to sleep in Atlanta and not Jacksonville Florida
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
2.0
Mediocre

Mark,Jun 2024

SGF - ATL

One of the worst flights ever. I got to the airport early for my 6:48 pm flight and tried to get on the 4:30 ish flight. The gate agent was one of the worst customer service people in my 20 yrs of flying Delta. Very rude and wouldn’t even talk to me about riding standby. Then flight took off 3 hrs late and when Landed in Atlanta, the gate people wouldn’t even try to get me on the plane. It was still there but door was closed. For all of my almost 2 million miles, the worst experience from Delta. I am highly disappointed as it was not my fault I have to sleep in Atlanta and not Jacksonville Florida
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
2.0
Mediocre

Mark,Jun 2024

SGF - ATL

One of the worst flights ever. I got to the airport early for my 6:48 pm flight and tried to get on the 4:30 ish flight. The gate agent was one of the worst customer service people in my 20 yrs of flying Delta. Very rude and wouldn’t even talk to me about riding standby. Then flight took off 3 hrs late and when Landed in Atlanta, the gate people wouldn’t even try to get me on the plane. It was still there but door was closed. For all of my almost 2 million miles, the worst experience from Delta. I am highly disappointed as it was not my fault I have to sleep in Atlanta and not Jacksonville Florida

Related info for your journey

Find useful and relevant information for your journey from Missouri to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from Missouri?

    Key West (EYW) is the airport you will fly into if you book a flight from Missouri to Key West. It is only a 2.6 mi journey from Key West (EYW) to Key West’s city center.

  • What are the cheapest airlines to fly from Missouri to Key West one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $230. However, be on the lookout for offers from United Airlines and Delta, as they are both options that can get you from Missouri to Key West for a low price.

  • What are the most popular routes from Missouri to Key West?

    When deciding which route to take from Missouri to Key West consider Lambert-St Louis - Key West, Kansas City - Key West or Springfield-Branson - Key West as they are the most popular.

  • Can I find deals for flights from Missouri to Key West that include hotel bookings?

    Yes. In addition to deals on Missouri to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Key West.

  • Can I find deals for business class flights from Missouri to Key West?

    Yes. Cheapflights offers flight deals from Missouri to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Key West?

    Currently, August is the cheapest month in which you can book a flight from Missouri to Key West (average of $328). Flying from Missouri to Key West in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 3 airlines flying from Missouri to Key West

Discover the top 3 airlines that operate flights from Missouri to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$189Average$403FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$213Average$430FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$268Average$486FlexibilityNo cancel feeOn-time69%

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