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Key West

$124+ Cheap flights from Missouri to Key West (EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/20. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — EYW
Jan 20 — Jan 271
Tue 1/20
Tue 1/27
1 adult, Economy
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Cheap flight deals from Missouri to Key West

Cheapest flights from Missouri to Key West
Explore the most affordable flight options available from Missouri to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 21, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:47 pmMCI - EYW
1 stop15h 28mMultiple Airlines
Wed 1/74:06 pmEYW - MCI
1 stop17h 03mMultiple Airlines
Deal found 12/20$309
This United Airlines deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/258:05 amSTL - EYW
1 stop6h 07mUnited Airlines
Sat 12/2712:22 pmEYW - STL
1 stop6h 32mUnited Airlines
Deal found 12/19$322
This United Airlines deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:00 amMCI - EYW
1 stop8h 14mUnited Airlines
Thu 12/254:29 pmEYW - MCI
1 stop7h 01mUnited Airlines
Deal found 12/19$336
This United Airlines deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:15 amSGF - EYW
1 stop8h 33mUnited Airlines
Sun 12/284:29 pmEYW - SGF
1 stop6h 30mUnited Airlines
Deal found 12/19$341
This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:47 pmMCI - EYW
1 stop15h 28mMultiple Airlines
Thu 1/810:06 amEYW - MCI
1 stop7h 03mMultiple Airlines
Deal found 12/20$355
This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:47 pmMCI - EYW
1 stop15h 28mMultiple Airlines
Mon 1/52:30 pmEYW - MCI
1 stop27h 40mMultiple Airlines
Deal found 12/20$358
This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:47 pmMCI - EYW
1 stop15h 28mMultiple Airlines
Tue 1/612:20 pmEYW - MCI
2 stops11h 39mMultiple Airlines
Deal found 12/20$378
This American Airlines deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:00 amSTL - EYW
1 stop6h 08mAmerican Airlines
Thu 1/18:00 amEYW - STL
1 stop6h 14mAmerican Airlines
Deal found 12/19$400
This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:57 amSGF - EYW
1 stop11h 45mAllegiant Air
Sat 12/2710:35 pmEYW - SGF
1 stop9h 56mAllegiant Air
Deal found 12/20$411
This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:32 amSGF - EYW
1 stop5h 07mAllegiant Air
Tue 12/3010:32 pmEYW - SGF
1 stop10h 10mAllegiant Air
Deal found 12/20$413
This Delta deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2410:59 amMCI - EYW
1 stop7h 44mDelta
Sat 12/276:20 pmEYW - MCI
1 stop6h 36mDelta
Deal found 12/19$414
This Delta deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2410:59 amMCI - EYW
1 stop7h 44mDelta
Mon 12/294:25 pmEYW - MCI
1 stop5h 43mDelta
Deal found 12/19$424

Find flight deals from Missouri to Key West

Keep the following information in mind while searching for Missouri to Key West flight deals. Data was last updated December 21, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$171
(Kiwi.com)

One-way from

$124
(Kiwi.com)

Popular in

March

Cheapest in

December

Average price

$345
Provider with most accurate pricing for Lambert-St Louis-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Key West flights.
Search Deals
From Missouri to Key West
Search Deals
One-way flight from Missouri to Key West
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($30 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 21, 2025.
Use the filters below to find and compare flights from Missouri to Key West that are best for you.

Fly from

Missouri

Fly to

Key West

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 1/7

5:11 pm-9:26 am

1 stop15h 15m

Key West

Fri 1/30

1:06 pm-11:33 pm

1 stop11h 27m

$171

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sun 1/18

5:11 pm-12:26 pm

1 stop18h 15m

Key West

Sun 1/25

10:06 am-9:21 am

1 stop24h 15m

$198

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 1/20

6:00 am-12:35 pm

1 stop5h 35m

Key West

Sat 1/24

2:04 pm-10:44 pm

1 stop9h 40m

$220

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/18

6:00 am-1:45 pm

1 stop6h 45m

Key West

Wed 3/25

11:29 am-5:40 pm

1 stop7h 11m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 1/24

6:30 am-4:22 pm

2 stops8h 52m

Key West

Wed 1/28

4:15 pm-10:58 pm

1 stop7h 43m

$228

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Thu 1/15

8:59 am-9:37 pm

1 stop11h 38m

Key West

Mon 1/19

2:25 pm-4:09 pm

2 stops26h 44m

$259

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Fri 1/9

11:26 am-10:09 am

2 stops21h 43m

Key West

Mon 1/12

1:06 pm-4:09 pm

1 stop28h 03m

$272

SpringfieldKey West

SGF - EYW

SGFEYW

Springfield-Branson

Fri 1/9

8:00 am-4:24 pm

1 stop7h 24m

Key West

Fri 1/16

1:16 pm-8:25 pm

1 stop8h 09m

$279

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Fri 1/9

10:58 am-6:01 pm

1 stop6h 03m

Key West

Mon 1/12

6:43 pm-11:35 pm

1 stop5h 52m

$289

SpringfieldKey West

SGF - EYW

SGFEYW

Springfield-Branson

Fri 1/23

12:26 pm-9:47 pm

2 stops8h 21m

Key West

Fri 1/30

7:08 am-4:14 pm

2 stops10h 06m

$289

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/20

Showing 1-10 of 33 results
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Best time to book a flight from Missouri to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Key West

What is the cheapest month to book a flight from Missouri to Key West?

Currently, April is the cheapest month in which you can book a flight from Missouri to Key West (average of $189). Flying from Missouri to Key West in August is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from Missouri?

    Key West (EYW) is the airport you will fly into if you book a flight from Missouri to Key West. It is only a 2.6 mi journey from Key West (EYW) to Key West’s city center.

  • How long is the flight from Missouri to Key West?

    There are many flights that can get you from Missouri to Key West in 5h 35m. Fly via American Airlines or United Airlines to get the fastest option. There are 1102 mi between Missouri and Key West. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Missouri to Key West?

    When deciding which route to take from Missouri to Key West consider Lambert-St Louis - Key West, Kansas City - Key West or Springfield-Branson - Key West as they are the most popular.

  • Can I find deals for flights from Missouri to Key West that include hotel bookings?

    Yes. In addition to deals on Missouri to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Key West.

  • Can I find deals for business class flights from Missouri to Key West?

    Yes. Cheapflights offers flight deals from Missouri to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Key West?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Key West (average of $189). Flying from Missouri to Key West in August is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Key West

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Key West

Discover the top 3 airlines that operate flights from Missouri to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$189Average$394FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$224Average$496FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$245Average$456FlexibilityNo cancel feeOn-time69%

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