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Key West

$157+ Cheap flights from Missouri to Key West (EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
Dec 2 — Dec 91
Tue 12/2
Tue 12/9
1 adult, Economy
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Cheap flight deals from Missouri to Key West

Keep the following information in mind while searching for Missouri to Key West flight deals. Data was last updated November 2, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$189
(Kiwi.com)

One-way from

$157
(Kiwi.com)

Popular in

March

Cheapest in

August

Average price

$438
Provider with most accurate pricing for Lambert-St Louis-Key West flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Key West flights.
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From Missouri to Key West
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One-way flight from Missouri to Key West
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Highest demand for flights based on searches. 5% potential increase in price ($25 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Missouri to Key West

Cheapest flights from Missouri to Key West
Explore the most affordable flight options available from Missouri to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2025.

This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/34:36 pmSTL - EYW
1 stop5h 31mAmerican Airlines
Sat 12/64:59 pmEYW - STL
1 stop6h 48mAmerican Airlines
Deal found 11/1$223
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/149:30 amSTL - EYW
1 stop6h 45mDelta
Sat 12/206:20 pmEYW - STL
1 stop6h 22mDelta
Deal found 10/31$241
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:00 amMCI - EYW
1 stop25h 15mMultiple Airlines
Sat 11/225:28 pmEYW - MCI
1 stop15h 37mMultiple Airlines
Deal found 11/1$243
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/152:04 pmSTL - EYW
2 stops8h 03mAmerican Airlines
Sat 12/2011:57 amEYW - STL
1 stop6h 54mAmerican Airlines
Deal found 11/1$246
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/33:30 pmSTL - EYW
1 stop15h 45mMultiple Airlines
Sun 12/78:55 amEYW - STL
1 stop14h 38mMultiple Airlines
Deal found 10/31$255
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/238:55 amMCI - EYW
1 stop11h 41mMultiple Airlines
Thu 11/278:55 amEYW - MCI
1 stop28h 08mMultiple Airlines
Deal found 11/1$255
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/810:47 amSTL - EYW
2 stops23h 18mMultiple Airlines
Fri 12/128:55 amEYW - STL
1 stop14h 38mMultiple Airlines
Deal found 10/31$262
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1610:35 amMCI - EYW
1 stop22h 16mMultiple Airlines
Thu 11/208:55 amEYW - MCI
1 stop28h 08mMultiple Airlines
Deal found 11/1$264
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1012:47 pmMCI - EYW
1 stop6h 19mDelta
Sat 12/136:10 pmEYW - MCI
1 stop6h 37mDelta
Deal found 11/1$269
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:05 amSTL - EYW
1 stop6h 09mUnited Airlines
Sat 12/275:43 pmEYW - STL
1 stop6h 50mUnited Airlines
Deal found 10/31$272
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/281:45 pmMCI - EYW
2 stops9h 05mAmerican Airlines
Fri 12/58:05 pmEYW - MCI
1 stop5h 20mAmerican Airlines
Deal found 10/31$274
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/111:44 pmMCI - EYW
2 stops8h 23mAmerican Airlines
Mon 12/154:10 pmEYW - MCI
2 stops8h 35mAmerican Airlines
Deal found 11/1$279

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
Use the filters below to find and compare flights from Missouri to Key West that are best for you.

Fly from

Missouri

Fly to

Key West

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 12/3

2:11 pm-11:07 pm

2 stops7h 56m

Key West

Sat 12/6

7:00 am-1:18 pm

2 stops7h 18m

$233

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Mon 12/15

9:30 am-4:07 pm

1 stop5h 37m

Key West

Sat 12/20

11:57 am-5:51 pm

1 stop6h 54m

$241

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Wed 11/19

6:00 am-8:15 am

1 stop25h 15m

Key West

Sat 11/22

5:28 pm-8:05 am

1 stop15h 37m

$243

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Fri 1/2

5:00 am-12:08 pm

1 stop6h 08m

Key West

Wed 1/7

7:08 am-2:50 pm

2 stops8h 42m

$246

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 1/24

8:13 am-6:52 pm

2 stops9h 39m

Key West

Thu 1/29

6:06 am-1:03 pm

2 stops7h 57m

$251

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Thu 1/29

9:59 am-5:13 pm

1 stop6h 14m

Key West

Mon 2/2

6:08 pm-11:39 pm

1 stop6h 31m

$259

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 1/6

11:51 am-1:30 pm

1 stop24h 39m

Key West

Sat 1/10

10:49 am-9:47 am

2 stops23h 58m

$262

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Sun 11/16

10:35 am-9:51 am

1 stop22h 16m

Key West

Thu 11/20

8:55 am-12:03 pm

1 stop28h 08m

$264

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Thu 1/29

3:54 pm-9:47 pm

1 stop4h 53m

Key West

Mon 2/2

6:06 am-3:04 pm

2 stops9h 58m

$264

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Tue 2/10

1:22 pm-7:42 pm

1 stop5h 20m

Key West

Wed 2/18

6:00 pm-12:01 am

1 stop7h 01m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/31

Showing 1-10 of 35 results
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Best time to book a flight from Missouri to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Key West

What is the cheapest month to book a flight from Missouri to Key West?

Currently, April is the cheapest month in which you can book a flight from Missouri to Key West (average of $189). Flying from Missouri to Key West in August is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Missouri to Key West?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from Missouri?

    Key West (EYW) is the airport you will fly into if you book a flight from Missouri to Key West. It is only a 2.6 mi journey from Key West (EYW) to Key West’s city center.

  • How long is the flight from Missouri to Key West?

    There are many flights that can get you from Missouri to Key West in 5h 20m. Fly via American Airlines, Delta, or United Airlines to get the fastest option. There are 1267 mi between Missouri and Key West. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Missouri to Key West?

    When deciding which route to take from Missouri to Key West consider Lambert-St Louis - Key West, Kansas City - Key West or Springfield-Branson - Key West as they are the most popular.

  • Can I find deals for flights from Missouri to Key West that include hotel bookings?

    Yes. In addition to deals on Missouri to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Key West.

  • Can I find deals for business class flights from Missouri to Key West?

    Yes. Cheapflights offers flight deals from Missouri to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Key West?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Key West (average of $189). Flying from Missouri to Key West in August is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Key West

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Key West

Discover the top 3 airlines that operate flights from Missouri to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$189Average$388FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$239Average$486FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$245Average$457FlexibilityNo cancel feeOn-time69%

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