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Key West

$182+ Cheap flights from Missouri to Key West (EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Missouri to Key West

Keep the following information in mind while searching for Missouri to Key West flight deals. Data was last updated September 16, 2025.

Round-trip from

$223
(American Airlines)

One-way from

$182
(Kiwi.com)

Popular in

May

Cheapest in

July

Average price

$337
From Missouri to Key West
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One-way flight from Missouri to Key West
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Highest demand for flights based on searches. 6% potential increase in price ($27 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Missouri to Key West

Cheapest flights from Missouri to Key West
Explore the most affordable flight options available from Missouri to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/118:13 amSTL - EYW
1 stop5h 42mAmerican Airlines
Tue 11/184:10 pmEYW - STL
1 stop7h 17mAmerican Airlines
Deal found 9/14$223
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:52 amSTL - EYW
2 stops9h 05mAmerican Airlines
Sat 12/61:57 pmEYW - STL
2 stops8h 31mAmerican Airlines
Deal found 9/14$233
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/188:13 amSTL - EYW
1 stop5h 42mAmerican Airlines
Mon 11/246:33 pmEYW - STL
1 stop5h 34mAmerican Airlines
Deal found 9/14$241
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:00 amSTL - EYW
1 stop5h 15mDelta
Mon 12/296:00 pmEYW - STL
1 stop6h 39mDelta
Deal found 9/14$256
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/233:35 pmSTL - EYW
1 stop4h 21mDelta
Tue 12/306:00 pmEYW - STL
1 stop6h 39mDelta
Deal found 9/14$259
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/410:15 amSTL - EYW
1 stop6h 36mAmerican Airlines
Sat 11/88:00 amEYW - STL
1 stop6h 17mAmerican Airlines
Deal found 9/14$266
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/269:25 amMCI - EYW
1 stop5h 39mMultiple Airlines
Sat 11/110:47 amEYW - MCI
2 stops25h 30mMultiple Airlines
Deal found 9/14$268
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/268:00 amMCI - EYW
1 stop6h 19mUnited Airlines
Sat 11/14:00 pmEYW - MCI
1 stop6h 50mUnited Airlines
Deal found 9/14$269
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/118:17 amSGF - EYW
1 stop8h 34mAmerican Airlines
Sat 11/154:18 pmEYW - SGF
1 stop7h 02mAmerican Airlines
Deal found 9/14$271
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/233:35 pmSTL - EYW
1 stop4h 21mDelta
Mon 12/296:00 pmEYW - STL
1 stop6h 39mDelta
Deal found 9/14$274
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/47:00 amMCI - EYW
2 stops9h 51mAmerican Airlines
Sat 11/812:40 pmEYW - MCI
1 stop6h 26mAmerican Airlines
Deal found 9/14$274
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/410:21 amSGF - EYW
2 stops10h 27mAmerican Airlines
Sat 11/81:57 pmEYW - SGF
2 stops9h 36mAmerican Airlines
Deal found 9/13$281

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Missouri to Key West that are best for you.

Fly from

Missouri

Fly to

Key West

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 12/6

2:09 pm-9:50 pm

1 stop6h 41m

Key West

Wed 12/10

7:00 am-3:29 pm

2 stops9h 29m

$228

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Mon 12/8

9:30 am-5:10 pm

1 stop6h 40m

Key West

Tue 12/16

6:05 pm-9:58 pm

1 stop4h 53m

$241

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 11/18

8:13 am-2:55 pm

1 stop5h 42m

Key West

Mon 11/24

6:33 pm-11:07 pm

1 stop5h 34m

$241

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Mon 12/8

2:04 pm-11:07 pm

2 stops8h 03m

Key West

Tue 12/16

7:00 am-3:27 pm

2 stops9h 27m

$251

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Mon 11/3

11:36 am-5:21 pm

1 stop4h 45m

Key West

Thu 11/13

12:26 pm-4:07 pm

1 stop4h 41m

$259

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 10/22

10:22 am-4:07 pm

1 stop4h 45m

Key West

Tue 10/28

7:52 pm-11:56 pm

1 stop5h 04m

$266

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 11/4

10:15 am-5:51 pm

1 stop6h 36m

Key West

Sat 11/8

8:00 am-1:17 pm

1 stop6h 17m

$266

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Sun 10/26

8:00 am-3:19 pm

1 stop6h 19m

Key West

Sat 11/1

4:00 pm-9:50 pm

1 stop6h 50m

$269

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Wed 2/18

12:30 pm-7:44 pm

1 stop6h 14m

Key West

Thu 2/26

7:00 am-11:35 am

1 stop5h 35m

$269

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Sun 10/26

5:55 am-11:27 am

1 stop4h 32m

Key West

Sat 11/1

6:17 pm-11:52 pm

1 stop6h 35m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 34 results
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Best time to book a flight from Missouri to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Key West

What is the cheapest month to book a flight from Missouri to Key West?

Currently, August is the cheapest month in which you can book a flight from Missouri to Key West (average of $328). Flying from Missouri to Key West in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to EYW?

Find hourly flight availability from Missouri to Key West. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

When flying from Missouri to Key West, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from Missouri?

    Key West (EYW) is the airport you will fly into if you book a flight from Missouri to Key West. It is only a 2.6 mi journey from Key West (EYW) to Key West’s city center.

  • How long is the flight from Missouri to Key West?

    There are many flights that can get you from Missouri to Key West in 6h 19m. Fly via American Airlines, Delta, or United Airlines to get the fastest option. There are 1149 mi between Missouri and Key West. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Missouri to Key West one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $222. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from Missouri to Key West for a low price.

  • What are the most popular routes from Missouri to Key West?

    When deciding which route to take from Missouri to Key West consider Lambert-St Louis - Key West, Kansas City - Key West or Springfield-Branson - Key West as they are the most popular.

  • Can I find deals for flights from Missouri to Key West that include hotel bookings?

    Yes. In addition to deals on Missouri to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Key West.

  • Can I find deals for business class flights from Missouri to Key West?

    Yes. Cheapflights offers flight deals from Missouri to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Key West?

    Currently, August is the cheapest month in which you can book a flight from Missouri to Key West (average of $328). Flying from Missouri to Key West in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Key West

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Key West

Discover the top 3 airlines that operate flights from Missouri to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$189Average$395FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$245Average$483FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$246Average$488FlexibilityNo cancel feeOn-time71%

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