$160+ Cheap flights from Medford (MFR) to Key Largo, FL
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/16. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — MIA
Sep 21 — Sep 281
Round-trip
1 adult, Economy
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Find cheap flights from Medford to Key Largo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Medford to Key Largo
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Best
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One-way
Cheapest flights from Medford to Key LargoExplore the most affordable flight options available from Medford to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 22, 2026.
Explore the most affordable flight options available from Medford to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 22, 2026.
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:05 am -
1 stop8h 22m
Wed 1/136:50 am -
1 stop8h 46m
Deal found 8/21![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:15 am -
2 stops13h 01m
Sat 11/147:00 am -
2 stops12h 47m
Deal found 8/18![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/257:45 pm -
1 stop9h 05m
Mon 11/28:45 am -
2 stops12h 24m
Deal found 8/18![United Airlines logo]()
$338
This Alaska Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/315:43 pm -
1 stop9h 27m
Tue 1/124:47 pm -
1 stop8h 50m
Deal found 8/18![Alaska Airlines logo]()
$359
This Expedia deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:58 pm -
2 stops12h 02m
Mon 9/146:16 pm -
1 stop8h 43m
Deal found 8/17![Alaska Airlines logo]()
$369
This Alaska Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:29 am -
1 stop27h 44m
Mon 9/216:16 pm -
1 stop8h 43m
Deal found 8/17![Alaska Airlines logo]()
$374
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:45 pm -
2 stops12h 48m
Fri 11/63:42 pm -
1 stop8h 36m
Deal found 8/19![United Airlines logo]()
$378
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1512:22 pm -
2 stops14h 27m
Tue 9/296:00 am -
2 stops13h 47m
Deal found 8/19![Delta logo]()
$385
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:00 am -
1 stop7h 56m
Wed 9/2311:30 am -
2 stops12h 38m
Deal found 8/20![United Airlines logo]()
$393
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/155:00 am -
2 stops12h 59m
Tue 9/297:35 am -
1 stop8h 22m
Deal found 8/18![American Airlines logo]()
$398
Best flights from Medford to Key LargoDiscover carefully curated flight deals from Medford to Key Largo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 22, 2026.
Discover carefully curated flight deals from Medford to Key Largo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 22, 2026.
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:45 pm -
1 stop9h 05m
Sat 11/149:15 am -
1 stop11h 54m
Deal found 8/18![United Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/76:05 am -
1 stop8h 22m
Wed 2/176:50 am -
1 stop8h 46m
Deal found 8/17![Delta logo]()
$309
This Alaska Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:29 am -
1 stop27h 44m
Mon 9/216:16 pm -
1 stop8h 43m
Deal found 8/17![Alaska Airlines logo]()
$374
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:05 am -
1 stop8h 22m
Wed 1/1312:01 pm -
2 stops14h 11m
Deal found 8/22![Delta logo]()
$314
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:15 am -
2 stops13h 01m
Sat 11/147:00 am -
2 stops12h 47m
Deal found 8/18![Delta logo]()
$319
This Alaska Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/105:02 am -
1 stop7h 42m
Thu 2/185:00 pm -
1 stop8h 55m
Deal found 8/17![Alaska Airlines logo]()
$399
This Alaska Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:58 pm -
1 stop19h 15m
Tue 9/296:16 pm -
1 stop8h 43m
Deal found 8/21![Alaska Airlines logo]()
$416
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1512:22 pm -
2 stops14h 27m
Tue 9/296:00 am -
2 stops13h 47m
Deal found 8/19![Delta logo]()
$385
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:15 am -
2 stops10h 43m
Wed 9/97:05 am -
1 stop7h 37m
Deal found 8/21![Delta logo]()
$418
Last-minute flights from Medford to Key LargoDiscover last-minute flight deals from Medford to Key Largo. Data last updated August 22, 2026 and is based on user searches.
Discover last-minute flight deals from Medford to Key Largo. Data last updated August 22, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/410:28 am -
1 stop27h 51m
Wed 9/96:16 pm -
1 stop8h 43m
Deal found 8/17![Alaska Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:15 am -
2 stops10h 43m
Wed 9/97:05 am -
1 stop7h 37m
Deal found 8/21![Delta logo]()
$418
This Priceline deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:00 am -
1 stop8h 19m
Thu 9/106:16 pm -
1 stop8h 43m
Deal found 8/22![Alaska Airlines logo]()
$413
This Expedia deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:58 pm -
2 stops12h 02m
Mon 9/146:16 pm -
1 stop8h 43m
Deal found 8/17![Alaska Airlines logo]()
$369
This Alaska Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:29 am -
1 stop27h 44m
Mon 9/216:16 pm -
1 stop8h 43m
Deal found 8/17![Alaska Airlines logo]()
$374
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1512:22 pm -
2 stops14h 27m
Tue 9/296:00 am -
2 stops13h 47m
Deal found 8/19![Delta logo]()
$385
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/155:00 am -
2 stops12h 59m
Tue 9/297:35 am -
1 stop8h 22m
Deal found 8/18![American Airlines logo]()
$398
This Alaska Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:58 pm -
1 stop19h 15m
Tue 9/296:16 pm -
1 stop8h 43m
Deal found 8/18![Alaska Airlines logo]()
$416
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1612:22 pm -
2 stops14h 27m
Tue 9/227:05 am -
2 stops12h 42m
Deal found 8/21![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:00 am -
1 stop7h 56m
Wed 9/2311:30 am -
2 stops12h 38m
Deal found 8/20![United Airlines logo]()
$393
One-way flights from Medford to Key LargoSearch for one-way flight options from Medford to Key Largo. Find affordable one-way fares based on user searches. Data last updated August 22, 2026.
Search for one-way flight options from Medford to Key Largo. Find affordable one-way fares based on user searches. Data last updated August 22, 2026.
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1612:22 pm -
2 stops14h 27m
Deal found 8/18![Delta logo]()
$160
This Alaska Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:00 am -
1 stop8h 13m
Deal found 8/18![Alaska Airlines logo]()
$180
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:13 am -
2 stops15h 42m
Deal found 8/18![Delta logo]()
$185
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:29 pm -
2 stops12h 56m
Deal found 8/18![Delta logo]()
$200
This Priceline deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:00 am -
1 stop8h 19m
Deal found 8/20![Alaska Airlines logo]()
$207
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:00 am -
1 stop8h 35m
Deal found 8/18![United Airlines logo]()
$210
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/512:20 pm -
2 stops14h 40m
Deal found 8/20![Delta logo]()
$212
This Alaska Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:58 pm -
2 stops12h 02m
Deal found 8/19![Alaska Airlines logo]()
$215
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1512:22 pm -
2 stops14h 27m
Deal found 8/19![Delta logo]()
$225
This Priceline deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/15:14 am -
1 stop7h 46m
Deal found 8/19![Alaska Airlines logo]()
$262
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/305:00 am -
1 stop7h 56m
Deal found 8/18![United Airlines logo]()
$280
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/305:20 am -
2 stops10h 30m
Deal found 8/18![American Airlines logo]()
$285
Find flight deals from Medford to Key Largo
Keep the following information in mind while searching for Medford to Key Largo flight deals. Data was last updated August 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $309 (Delta) |
One-way from | $160 (Delta) |
Popular in | December |
Cheapest in | October |
Average price | $576 |
Cheapflights Fare Finder
Customize your flight search to find flights from Medford to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 22, 2026.
Use the filters below to find and compare flights from Medford to Key Largo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
MedfordMiami
MFR Medford - MIA Miami
MFRMIA
Medford
Sun 11/1
7:45 pm-7:50 am
1 stop9h 05m
Miami
Sat 11/14
9:15 am-6:09 pm
1 stop11h 54m
$309
MedfordMiami
MFR Medford - MIA Miami
MFRMIA
Medford
Sun 2/7
6:05 am-5:27 pm
1 stop8h 22m
Miami
Wed 2/17
6:50 am-12:36 pm
1 stop8h 46m
$309
MedfordMiami
MFR Medford - MIA Miami
MFRMIA
Medford
Wed 12/30
6:05 am-5:27 pm
1 stop8h 22m
Miami
Wed 1/13
12:01 pm-11:12 pm
2 stops14h 11m
$314
MedfordMiami
MFR Medford - MIA Miami
MFRMIA
Medford
Sun 11/1
5:15 am-9:16 pm
2 stops13h 01m
Miami
Sat 11/14
7:00 am-4:47 pm
2 stops12h 47m
$319
MedfordMiami
MFR Medford - MIA Miami
MFRMIA
Medford
Tue 9/15
10:29 am-5:13 pm
1 stop27h 44m
Miami
Mon 9/21
6:16 pm-11:59 pm
1 stop8h 43m
$374
MedfordMiami
MFR Medford - MIA Miami
MFRMIA
Medford
Tue 9/15
12:22 pm-5:49 am
2 stops14h 27m
Miami
Tue 9/29
6:00 am-4:47 pm
2 stops13h 47m
$385
Quickest round-trip
MedfordMiami
MFR Medford - MIA Miami
MFRMIA
Medford
Wed 2/10
5:02 am-3:44 pm
1 stop7h 42m
Miami
Thu 2/18
5:00 pm-10:55 pm
1 stop8h 55m
$399
MedfordMiami
MFR Medford - MIA Miami
MFRMIA
Medford
Tue 9/15
6:58 pm-5:13 pm
1 stop19h 15m
Miami
Tue 9/29
6:16 pm-11:59 pm
1 stop8h 43m
$416
MedfordMiami
MFR Medford - MIA Miami
MFRMIA
Medford
Sat 9/5
7:15 am-8:58 pm
2 stops10h 43m
Miami
Wed 9/9
7:05 am-11:42 am
1 stop7h 37m
$418
Cheapest one-way
MedfordMiami
MFR Medford - MIA Miami
MFRMIA
Medford
Wed 9/16
12:22 pm-5:49 am
2 stops14h 27m
$160
Showing 1-10 of 17 resultsSorted by cheapest first
Best time to book a flight from Medford to Key Largo
Have a flexible travel schedule? Discover the best time to fly to Key Largo from Medford with our price prediction graph.
MFR-MIA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Medford to Key Largo
MFR-KE9
MFR-MIA
How much does it cost to fly round-trip from Medford to Key Largo?
Airfare is below average for this route at the moment.
Medford to Key Largo flights typically cost between $424 and $618 in December.The cheapest round-trip price found within the last 5 days was $309 on Delta (Dec 30-Jan 13).
Reviews of airlines servicing Key Largo
Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated August 22, 2026.
See what other customers who have flown with Alaska Airlines,United Airlines, andAmerican Airlines from Medford to Key Largo have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Overall
7.9
Food
7.0
Entertainment
7.0
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentEugene,Mar 2026
MFR - SEA
Crew
8.5
Overall
7.9
Food
7.0
Entertainment
7.0
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentEugene,Mar 2026
MFR - SEA
Crew
8.5
Overall
7.9
Food
7.0
Entertainment
7.0
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentEugene,Mar 2026
MFR - SEA
Crew
8.5
Overall
7.9
Food
7.0
Entertainment
7.0
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentEugene,Mar 2026
MFR - SEA
Related info for your journey
Find useful and relevant information for your journey from Medford to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Medford to Key Largo
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Complete your trip
Complete your trip to Key Largo by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Medford to Key Largo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Medford and Key Largo flights
Browse other Medford and Key Largo flight options. Last updated on August 22, 2026.
Other flights from Medford
Browse through other flights departing from Medford. Flights are based on user searches made on Cheapflights and were last updated on August 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Medford to Key Largo flights
Consider these flights traveling from Medford to Key Largo.
Top 4 airlines flying from Medford to Key Largo
Discover the top 4 airlines that operate flights from Medford to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$267 | Average$417 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$286 | Average$485 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$344 | Average$501 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$448 | Average$586 | FlexibilityNo cancel fee | On-time71% |