How long is the flight from South Carolina to Italy?

For as low as $458, Brussels Airlines can have you in Italy from South Carolina in 12h 17m. The distance from South Carolina to Italy is about 4941 mi. This flight may include one or multiple stops.

In terms of precipitation, rainfall in Italy ranges from 0.6 - 4.4 inches per month. November is typically the wettest month, when rainfall can reach 4.4 in. June is typically the driest time to visit Italy when rainfall is around 0.6 in.

If weather is an important factor for your trip to Italy, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 75.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 46.4 F).

Can I find deals for flights from South Carolina to Italy that include hotel bookings?

Yes. In addition to deals on South Carolina to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from South Carolina to Italy?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Italy.

Can I find deals for business class flights from South Carolina to Italy?

Yes. Cheapflights offers flight deals from South Carolina to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$226+ Flights from South Carolina to Italy

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Cheap flight deals from South Carolina to Italy

Cheapest flights from South Carolina to Italy
Explore the most affordable flight options available from South Carolina to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 2, 2026.

Wed 12/317:05 amCLT - MXP

1 stop20h 00mMultiple Airlines

Fri 1/912:35 pmMXP - CLT

2 stops16h 31mMultiple Airlines

Deal found 12/31

$663

Wed 12/314:05 pmCLT - MXP

2 stops16h 50mDelta

Fri 1/911:35 amMXP - CLT

2 stops17h 31mDelta

Deal found 12/31

$667

Wed 12/312:54 pmCLT - MXP

2 stops13h 56mUnited Airlines

Fri 1/91:05 pmMXP - CLT

2 stops34h 19mUnited Airlines

Deal found 12/31

$704

Wed 12/312:54 pmCLT - FCO

1 stop11h 36mBrussels Airlines

Wed 1/76:00 pmFCO - CLT

2 stops30h 59mBrussels Airlines

Deal found 12/30

$1,039

Wed 12/312:54 pmCLT - FCO

1 stop11h 36mMultiple Airlines

Wed 1/77:05 amFCO - CLT

2 stops19h 52mMultiple Airlines

Deal found 12/30

$1,058

Wed 12/314:15 pmCLT - FCO

1 stop10h 45mBritish Airways

Wed 1/78:30 pmFCO - CLT

1 stop25h 35mBritish Airways

Deal found 12/30

$1,074

Best flights from South Carolina to Italy
Discover carefully curated flight deals from South Carolina to Italy that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated January 2, 2026.

Thu 1/292:13 pmSAV - FCO

1 stop12h 17mBrussels Airlines

Wed 2/118:25 amFCO - SAV

2 stops17h 00mBrussels Airlines

Deal found 12/31

$458

Sat 1/317:19 pmSAV - FCO

1 stop31h 11mUnited Airlines

Mon 2/911:15 amFCO - SAV

2 stops38h 10mUnited Airlines

Deal found 12/31

$488

Mon 3/95:30 pmCLT - LIN

2 stops22h 10mLufthansa

Tue 3/179:45 amLIN - CLT

1 stop13h 10mLufthansa

Deal found 12/30

$491

Fri 2/273:07 pmCHS - MXP

1 stop11h 58mDelta

Mon 3/98:30 amMXP - CHS

2 stops18h 54mDelta

Deal found 1/1

$496

Fri 1/306:40 amSAV - FCO

2 stops20h 45mAir Canada

Sun 2/812:45 pmFCO - SAV

2 stops40h 01mAir Canada

Deal found 1/1

$496

Thu 1/292:53 pmSAV - FCO

1 stop13h 37mKLM

Wed 2/1112:00 pmFCO - SAV

1 stop34h 23mKLM

Deal found 12/31

$498

Sat 2/146:00 amGSP - FCO

2 stops24h 10mBritish Airways

Sun 2/226:50 pmFCO - GSP

2 stops31h 56mBritish Airways

Deal found 1/1

$509

Wed 1/144:07 pmCLT - LIN

2 stops13h 23mAmerican Airlines

Mon 1/196:55 pmLIN - CLT

1 stop25h 20mAmerican Airlines

Deal found 12/31

$514

Wed 1/286:00 amCLT - FLR

3 stops25h 50mMultiple Airlines

Wed 2/43:10 pmFLR - CLT

2 stops14h 49mMultiple Airlines

Deal found 12/30

$529

Mon 3/306:00 amCLT - FLR

2 stops31h 05mScandinavian Airlines

Tue 4/77:55 pmFLR - CLT

2 stops32h 38mScandinavian Airlines

Deal found 12/31

$642

Sun 4/512:26 pmCHS - FCO

1 stop17h 39mFinnair

Tue 4/146:45 pmFCO - CHS

2 stops33h 16mFinnair

Deal found 12/31

$652

Mon 3/97:01 amCLT - MXP

2 stops20h 54mUnited Airlines

Tue 3/1712:05 pmMXP - CLT

2 stops30h 04mUnited Airlines

Deal found 1/1

$490

Sat 1/311:13 pmCHS - FCO

2 stops23h 02mLufthansa

Sat 2/77:05 amFCO - CHS

2 stops22h 39mLufthansa

Deal found 1/1

$494

Fri 1/307:00 amSAV - FCO

1 stop20h 45mKLM

Sun 2/812:40 pmFCO - SAV

1 stop17h 18mKLM

Deal found 12/31

$507

Mon 2/95:25 pmCLT - LIN

2 stops18h 20mBritish Airways

Mon 2/165:15 pmLIN - CLT

2 stops31h 06mBritish Airways

Deal found 1/1

$510

Tue 4/711:10 amCHS - MXP

2 stops17h 10mAir Canada

Thu 4/2312:20 pmMXP - CHS

2 stops41h 39mAir Canada

Deal found 1/2

$534

Mon 2/27:50 amCLT - VCE

2 stops24h 20mMultiple Airlines

Wed 2/116:55 amVCE - CLT

2 stops15h 22mMultiple Airlines

Deal found 12/31

$535

Sat 4/47:52 pmCLT - MXP

2 stops21h 08mDelta

Wed 4/159:00 amMXP - CLT

1 stop19h 49mDelta

Deal found 1/1

$538

Wed 3/116:15 amCLT - MXP

2 stops21h 40mUnited Airlines

Tue 3/2412:05 pmMXP - CLT

2 stops38h 26mUnited Airlines

Deal found 12/31

$490

Fri 1/302:05 pmSAV - FCO

2 stops21h 35mLufthansa

Fri 2/67:05 amFCO - SAV

2 stops18h 20mLufthansa

Deal found 1/1

$506

Sat 1/312:53 pmSAV - FCO

1 stop13h 37mKLM

Mon 2/912:40 pmFCO - SAV

1 stop17h 18mKLM

Deal found 12/31

$507

Wed 3/117:20 pmCLT - LIN

1 stop14h 10mAmerican Airlines

Sun 3/2910:50 amLIN - CLT

1 stop15h 55mAmerican Airlines

Deal found 12/31

$560

Thu 2/57:45 pmCHS - FCO

2 stops31h 40mUnited Airlines

Mon 2/911:15 amFCO - CHS

2 stops37h 49mUnited Airlines

Deal found 12/30

$491

Tue 3/3110:13 amCLT - MXP

2 stops18h 07mAir Canada

Wed 4/812:20 pmMXP - CLT

2 stops35h 04mAir Canada

Deal found 1/1

$544

Sun 4/56:00 amCLT - LIN

2 stops20h 50mDelta

Wed 4/1511:00 amLIN - CLT

2 stops17h 49mDelta

Deal found 1/1

$546

Mon 2/26:30 pmCLT - VCE

1 stop16h 20mBritish Airways

Wed 2/118:35 pmVCE - CLT

1 stop25h 15mBritish Airways

Deal found 12/31

$553

Mon 1/196:50 pmCLT - VCE

1 stop11h 30mMultiple Airlines

Tue 2/33:15 pmVCE - CLT

2 stops31h 24mMultiple Airlines

Deal found 1/1

$555

Sat 1/3110:31 amCHS - FCO

1 stop17h 59mKLM

Sat 2/712:00 pmFCO - CHS

1 stop16h 22mKLM

Deal found 1/1

$508

Mon 1/1911:15 pmCLT - VCE

1 stop15h 05mAmerican Airlines

Tue 2/36:20 amVCE - CLT

1 stop15h 45mAmerican Airlines

Deal found 1/1

$588

Wed 4/2910:34 amCLT - MXP

1 stop20h 46mLufthansa

Thu 5/72:40 pmMXP - CLT

2 stops14h 49mLufthansa

Deal found 12/31

$537

Last-minute flights from South Carolina to Italy
Discover last-minute flight deals from South Carolina to Italy. Data last updated January 2, 2026 and is based on user searches.

Wed 1/283:15 pmCLT - FCO

1 stop14h 30mMultiple Airlines

Wed 2/410:15 amFCO - CLT

1 stop15h 57mMultiple Airlines

Deal found 12/31

$487

Thu 1/292:58 pmCHS - FCO

1 stop11h 32mLufthansa

Wed 2/117:05 amFCO - CHS

2 stops16h 54mLufthansa

Deal found 1/1

$441

Thu 1/292:13 pmSAV - FCO

1 stop12h 17mBrussels Airlines

Wed 2/118:25 amFCO - SAV

2 stops17h 00mBrussels Airlines

Deal found 12/31

$458

Thu 1/297:00 pmCHS - MXP

1 stop30h 30mUnited Airlines

Wed 2/119:45 amMXP - CHS

2 stops15h 19mUnited Airlines

Deal found 12/31

$482

Thu 1/292:13 pmSAV - FCO

1 stop12h 17mLufthansa

Thu 2/57:05 amFCO - SAV

2 stops21h 41mLufthansa

Deal found 1/1

$487

Thu 1/293:15 pmCLT - FCO

2 stops26h 50mMultiple Airlines

Thu 2/56:00 amFCO - CLT

2 stops23h 59mMultiple Airlines

Deal found 12/31

$488

Thu 1/297:00 pmCHS - FCO

2 stops32h 25mMultiple Airlines

Wed 2/117:05 amFCO - CHS

2 stops17h 59mMultiple Airlines

Deal found 1/1

$492

Thu 1/292:53 pmSAV - FCO

1 stop13h 37mKLM

Wed 2/1112:00 pmFCO - SAV

1 stop34h 23mKLM

Deal found 12/31

$498

Fri 1/306:40 amSAV - FCO

2 stops20h 45mAir Canada

Sun 2/812:45 pmFCO - SAV

2 stops40h 01mAir Canada

Deal found 1/1

$496

Sat 1/312:05 pmSAV - FCO

1 stop11h 50mMultiple Airlines

Mon 2/911:00 amFCO - SAV

1 stop14h 25mMultiple Airlines

Deal found 1/1

$484

Sat 1/317:19 pmSAV - FCO

1 stop31h 11mUnited Airlines

Mon 2/911:15 amFCO - SAV

2 stops38h 10mUnited Airlines

Deal found 12/31

$488

Sat 1/311:13 pmCHS - FCO

2 stops23h 02mLufthansa

Sat 2/77:05 amFCO - CHS

2 stops22h 39mLufthansa

Deal found 1/1

$494

One-way flights from South Carolina to Italy
Search for one-way flight options from South Carolina to Italy. Find affordable one-way fares based on user searches. Data last updated January 2, 2026.

Tue 4/149:34 pmCLT - LIN

2 stops35h 31mBritish Airways

Deal found 12/31

$226

Mon 2/211:12 amCLT - FCO

3 stops51h 33mMultiple Airlines

Deal found 1/1

$235

Tue 4/147:54 pmCLT - MXP

1 stop31h 11mBritish Airways

Deal found 12/31

$236

Tue 3/37:00 amCLT - FCO

2 stops30h 00mMultiple Airlines

Deal found 12/31

$260

Tue 4/149:21 amCLT - MXP

2 stops47h 29mMultiple Airlines

Deal found 12/31

$264

Mon 2/93:21 pmCHS - FCO

3 stops47h 24mMultiple Airlines

Deal found 1/1

$267

Thu 1/297:00 amCLT - FCO

2 stops28h 50mMultiple Airlines

Deal found 1/1

$270

Tue 3/314:06 pmCLT - MXP

2 stops15h 19mBritish Airways

Deal found 12/31

$282

Tue 3/313:12 pmCLT - FCO

3 stops47h 33mMultiple Airlines

Deal found 12/31

$285

Tue 3/3111:50 pmCLT - MXP

1 stop17h 55mAmerican Airlines

Deal found 12/31

$285

Mon 3/302:37 pmCLT - FCO

3 stops48h 08mMultiple Airlines

Deal found 12/31

$298

Sun 3/16:50 pmCLT - MXP

2 stops17h 25mSWISS

Deal found 1/1

$300

Find flight deals from South Carolina to Italy

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$441 (Kiwi.com)
One-way from	$226 (oojo)
Popular in	June
Cheapest in	January
Average price	$519

Provider with most accurate pricing for Myrtle Beach Intl-Rome (ROM) flight deals.

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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Rome (ROM) flights.

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From South Carolina to Italy

Search Deals

One-way flight from South Carolina to Italy

Search Deals

Highest demand for flights based on searches. 27% potential increase in price ($402 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 6% potential price decrease ($68 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in January 2026

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Italy that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SavannahRome

SAV - FCO

SAVFCO

Savannah/Hilton Head

Thu 1/29

2:13 pm-8:30 am

1 stop12h 17m

Rome Fiumicino

Wed 2/11

8:25 am-7:25 pm

2 stops17h 00m

$458

SavannahRome

SAV - FCO

SAVFCO

Savannah/Hilton Head

Sat 1/31

7:19 pm-8:30 am

1 stop31h 11m

Rome Fiumicino

Mon 2/9

11:15 am-7:25 pm

2 stops38h 10m

$488

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Mon 3/9

7:01 am-8:55 am

2 stops20h 54m

Milan Malpensa

Tue 3/17

12:05 pm-1:09 pm

2 stops30h 04m

$490

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Wed 3/11

6:15 am-8:55 am

2 stops21h 40m

Milan Malpensa

Tue 3/24

12:05 pm-9:31 pm

2 stops38h 26m

$490

CharlotteMilan

CLT - LIN

CLTLIN

Charlotte Douglas

Mon 3/9

5:30 pm-8:40 pm

2 stops22h 10m

Milan Linate

Tue 3/17

9:45 am-5:55 pm

1 stop13h 10m

$491

CharlestonRome

CHS - FCO

CHSFCO

Charleston

Thu 2/5

7:45 pm-9:25 am

2 stops31h 40m

Rome Fiumicino

Mon 2/9

11:15 am-7:04 pm

2 stops37h 49m

$491

CharlestonRome

CHS - FCO

CHSFCO

Charleston

Sat 1/31

1:13 pm-6:15 pm

2 stops23h 02m

Rome Fiumicino

Sat 2/7

7:05 am-11:44 pm

2 stops22h 39m

$494

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Fri 2/27

3:07 pm-9:05 am

1 stop11h 58m

Milan Malpensa

Mon 3/9

8:30 am-10:24 pm

2 stops18h 54m

$496

SavannahRome

SAV - FCO

SAVFCO

Savannah/Hilton Head

Fri 1/30

6:40 am-9:25 am

2 stops20h 45m

Rome Fiumicino

Sun 2/8

12:45 pm-10:46 pm

2 stops40h 01m

$496

SavannahRome

SAV - FCO

SAVFCO

Savannah/Hilton Head

Thu 1/29

2:53 pm-10:30 am

1 stop13h 37m

Rome Fiumicino

Wed 2/11

12:00 pm-4:23 pm

1 stop34h 23m

$498

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/31

Showing 1-10 of 60 results

...

Best time to book a flight from South Carolina to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from South Carolina with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Italy

What is the cheapest month to book a flight from South Carolina to Italy?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $181). Flying from South Carolina to Italy in July is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IT?

One of the essential ways to save on airfare from South Carolina to Italy is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 33% on airfare.

Related info for your journey

How long is the flight from South Carolina to Italy?
For as low as $458, Brussels Airlines can have you in Italy from South Carolina in 12h 17m. The distance from South Carolina to Italy is about 4941 mi. This flight may include one or multiple stops.
Can I find deals for flights from South Carolina to Italy that include hotel bookings?
Yes. In addition to deals on South Carolina to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from South Carolina to Italy?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Italy.
Can I find deals for business class flights from South Carolina to Italy?
Yes. Cheapflights offers flight deals from South Carolina to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from South Carolina to Italy?
Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $181). Flying from South Carolina to Italy in July is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 7 airlines flying from South Carolina to Italy

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$307	Average$1,063	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$511	Average$1,180	FlexibilityNo cancel fee	On-timeN/A
KLM	Cheapest$555	Average$1,053	FlexibilityNo cancel fee	On-time75%
Lufthansa	Cheapest$591	Average$1,196	FlexibilityNo cancel fee	On-time76%
British Airways	Cheapest$609	Average$1,015	FlexibilityNo cancel fee	On-time70%
American Airlines	Cheapest$674	Average$1,189	FlexibilityNo cancel fee	On-time71%
Air France	Cheapest$957	Average$1,308	FlexibilityNo cancel fee	On-time77%

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$226+ Cheap flights from South Carolina to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/14. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from South Carolina to Italy with Cheapflights

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Cheap flight deals from South Carolina to Italy

Cheapest flights from South Carolina to ItalyExplore the most affordable flight options available from South Carolina to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 2, 2026.

Explore the most affordable flight options available from South Carolina to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 2, 2026.

Find flight deals from South Carolina to Italy

Keep the following information in mind while searching for South Carolina to Italy flight deals. Data was last updated January 2, 2026.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Italy that are best for you.

Best time to book a flight from South Carolina to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from South Carolina with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Italy

What is the cheapest month to book a flight from South Carolina to Italy?

What is the cheapest time of day to fly from SC to IT?

Find hourly flight availability from South Carolina to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 2, 2026.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from South Carolina to Italy?

Can I find deals for flights from South Carolina to Italy that include hotel bookings?

How can I find direct flights from South Carolina to Italy?

Can I find deals for business class flights from South Carolina to Italy?

What is the cheapest month to book a flight from South Carolina to Italy?

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Alternative routes for South Carolina to Italy

See prices for flight routes from nearby airports that may be better suited for you.

Top 7 airlines flying from South Carolina to Italy

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Cheapest flights from South Carolina to Italy
Explore the most affordable flight options available from South Carolina to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 2, 2026.