HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Italy

$228+ Cheap flights from South Carolina to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — NAP
Jan 1 — Jan 81
Thu 1/1
Thu 1/8
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from South Carolina to Italy with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from South Carolina to Italy

Cheapest flights from South Carolina to Italy
Explore the most affordable flight options available from South Carolina to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 2, 2025.

This KLM deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:59 pmCLT - MXP
1 stop31h 06mKLM
Wed 1/1412:00 pmMXP - CLT
1 stop17h 06mKLM
Deal found 11/30$432
This American Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/96:25 pmCLT - LIN
1 stop15h 20mAmerican Airlines
Wed 12/244:35 pmLIN - CLT
1 stop27h 35mAmerican Airlines
Deal found 11/29$445
This KLM deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:59 pmCLT - MXP
1 stop31h 06mMultiple Airlines
Wed 1/1412:35 pmMXP - CLT
2 stops16h 31mMultiple Airlines
Deal found 11/30$457
This FlightHub deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/306:50 pmCLT - MXP
1 stop15h 50mMultiple Airlines
Fri 12/121:05 pmMXP - CLT
2 stops38h 34mMultiple Airlines
Deal found 11/30$481
This Cheapflightsfares deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/306:50 pmCLT - MXP
1 stop19h 55mLufthansa
Fri 12/126:05 amMXP - CLT
1 stop16h 50mLufthansa
Deal found 11/30$493
This Cheapflightsfares deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/306:50 pmCLT - LIN
1 stop18h 00mLufthansa
Fri 12/129:35 amLIN - CLT
1 stop13h 20mLufthansa
Deal found 11/30$497
This Cheapflightsfares deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/911:33 amCHS - FCO
1 stop14h 12mLufthansa
Sat 12/2010:30 amFCO - CHS
1 stop19h 14mLufthansa
Deal found 11/30$499
This oojo deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:30 pmCLT - MXP
2 stops21h 30mBritish Airways
Fri 1/912:45 pmMXP - CLT
2 stops30h 50mBritish Airways
Deal found 12/2$500
This Air Canada deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/305:05 pmCLT - MXP
2 stops34h 50mAir Canada
Fri 12/121:05 pmMXP - CLT
2 stops37h 52mAir Canada
Deal found 11/30$504
This Delta deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1012:51 pmCHS - FCO
1 stop15h 39mDelta
Sun 12/149:20 amFCO - CHS
1 stop17h 41mDelta
Deal found 11/29$506
This United Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1011:00 amCHS - FCO
2 stops15h 30mUnited Airlines
Sun 12/149:45 amFCO - CHS
1 stop15h 45mUnited Airlines
Deal found 11/30$511
This oojo deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:37 pmCLT - MXP
1 stop32h 28mBritish Airways
Thu 1/88:50 pmMXP - CLT
2 stops30h 52mBritish Airways
Deal found 12/2$521

Find flight deals from South Carolina to Italy

Keep the following information in mind while searching for South Carolina to Italy flight deals. Data was last updated December 2, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$417
(Mytrip)

One-way from

$228
(Kiwi.com)

Popular in

June

Cheapest in

January

Average price

$1,511
Provider with most accurate pricing for Myrtle Beach Intl-Rome (ROM) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Rome (ROM) flights.
Search Deals
From South Carolina to Italy
Search Deals
One-way flight from South Carolina to Italy
Search Deals
Highest demand for flights based on searches. 28% potential increase in price ($426 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($76 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 2, 2025.
Use the filters below to find and compare flights from South Carolina to Italy that are best for you.

Fly from

South Carolina

Fly to

Italy

Route

Depart

Return

Price

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Wed 1/14

6:10 am-9:55 am

2 stops21h 45m

Milan Malpensa

Wed 1/21

1:05 pm-1:34 pm

2 stops30h 29m

$417

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Mon 1/19

6:00 am-9:45 am

1 stop21h 45m

Milan Malpensa

Tue 2/3

11:05 am-11:55 pm

1 stop18h 50m

$432

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Mon 1/19

6:05 am-7:30 am

2 stops19h 25m

Milan Malpensa

Tue 2/3

9:45 am-5:59 pm

1 stop14h 14m

$432

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Tue 12/23

7:59 pm-9:05 am

1 stop31h 06m

Milan Malpensa

Wed 1/14

12:00 pm-11:06 pm

1 stop17h 06m

$432

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Wed 1/14

6:00 am-9:55 am

2 stops21h 55m

Milan Malpensa

Wed 1/28

9:45 am-11:44 pm

1 stop19h 59m

$440

CharlotteNaples

CLT - NAP

CLTNAP

Charlotte Douglas

Sun 1/18

6:50 pm-12:30 pm

1 stop11h 40m

Naples

Mon 2/2

1:15 pm-6:59 pm

2 stops35h 44m

$441

CharlotteMilan

CLT - LIN

CLTLIN

Charlotte Douglas

Wed 1/14

8:25 pm-2:30 pm

1 stop12h 05m

Milan Linate

Mon 1/19

6:55 pm-2:15 pm

1 stop25h 20m

$443

CharlotteVenice

CLT - VCE

CLTVCE

Charlotte Douglas

Wed 1/14

8:29 pm-7:30 pm

2 stops17h 01m

Venice Marco Polo

Wed 1/21

11:25 am-9:29 pm

2 stops16h 04m

$444

CharlotteVenice

CLT - VCE

CLTVCE

Charlotte Douglas

Wed 1/14

2:54 pm-1:05 pm

2 stops16h 11m

Venice Marco Polo

Wed 1/21

1:30 pm-4:55 pm

1 stop33h 25m

$444

CharlotteMilan

CLT - LIN

CLTLIN

Charlotte Douglas

Tue 12/9

6:25 pm-3:45 pm

1 stop15h 20m

Milan Linate

Wed 12/24

4:35 pm-2:10 pm

1 stop27h 35m

$445

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/30

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from South Carolina to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Italy

What is the cheapest month to book a flight from South Carolina to Italy?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $181). Flying from South Carolina to Italy in July is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IT?

Find hourly flight availability from South Carolina to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 2, 2025.

One of the essential ways to save on airfare from South Carolina to Italy is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 11% on airfare.

What is the cheapest day to fly from South Carolina to Italy?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Italy. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to Italy flight should consider departing on Wednesday evenings when fares are most often at their lowest. Saturday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Italy?

    For as low as $441, United Airlines can have you in Italy from South Carolina in 11h 40m. The distance from South Carolina to Italy is about 4921 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to Italy one-way?

    $298 is the cheapest one-way deal found within the past few days, from Neos Air. You may also be able to find cheap deals on Air France and Iberia, with prices starting from $369 and $372, respectively.

  • Can I find deals for flights from South Carolina to Italy that include hotel bookings?

    Yes. In addition to deals on South Carolina to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Italy.

  • Can I find deals for business class flights from South Carolina to Italy?

    Yes. Cheapflights offers flight deals from South Carolina to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Italy?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $181). Flying from South Carolina to Italy in July is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Italy

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Heathrow flights
Newark to Heathrow flights
John F Kennedy Intl to Charles de Gaulle flights
Newark to Charles de Gaulle flights
John F Kennedy Intl to Leonardo da Vinci/Fiumicino flights
Newark to Leonardo da Vinci/Fiumicino flights
LaGuardia to Heathrow flights
John F Kennedy Intl to London City flights
Boston to Heathrow flights
John F Kennedy Intl to Istanbul flights
John F Kennedy Intl to Gatwick flights
John F Kennedy Intl to Orly flights
Dulles Intl to Heathrow flights
Newark to Gatwick flights
Newark to Orly flights
Miami to Madrid flights
LaGuardia to Gatwick flights
John F Kennedy Intl to Stansted flights
Los Angeles to Heathrow flights
San Francisco to Heathrow flights
LaGuardia to Charles de Gaulle flights
John F Kennedy Intl to Dublin flights
Newark to Madrid flights
Newark to Malpensa flights
Los Angeles to Charles de Gaulle flights
John F Kennedy Intl to Lisbon flights
Boston to Charles de Gaulle flights
John F Kennedy Intl to Malpensa flights
John F Kennedy Intl to Barcelona-El Prat flights
Newark to Athens flights
Newark to Barcelona-El Prat flights
Newark to Dublin flights
Newark to Lisbon flights
O'Hare Intl to Charles de Gaulle flights
O'Hare Intl to Heathrow flights
John F Kennedy Intl to Madrid flights
Seattle to Heathrow flights
Baltimore to Heathrow flights
Dulles Intl to Charles de Gaulle flights
Dallas/Fort Worth to Heathrow flights
John F Kennedy Intl to Luton flights
O'Hare Intl to Leonardo da Vinci/Fiumicino flights
San Francisco to Charles de Gaulle flights
Dulles Intl to Leonardo da Vinci/Fiumicino flights
Newark to Frankfurt flights
John F Kennedy Intl to Amsterdam flights
Dallas/Fort Worth to Charles de Gaulle flights
Boston to Dublin flights
Boston to Leonardo da Vinci/Fiumicino flights
Newark to London City flights

Top 7 airlines flying from South Carolina to Italy

Discover the top 7 airlines that operate flights from South Carolina to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$307Average$1,063FlexibilityNo cancel feeOn-time69%
DeltaCheapest$547Average$1,219FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$555Average$1,061FlexibilityNo cancel feeOn-time75%
American AirlinesCheapest$628Average$1,180FlexibilityNo cancel feeOn-time71%
LufthansaCheapest$635Average$1,199FlexibilityNo cancel feeOn-time76%
British AirwaysCheapest$714Average$1,091FlexibilityNo cancel feeOn-time70%
Air FranceCheapest$957Average$1,308FlexibilityNo cancel feeOn-time77%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.