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Italy

$251+ Cheap flights from South Carolina to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/30. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — NAP
Mar 5 — Mar 121
Thu 3/5
Thu 3/12
1 adult, Economy
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Cheap flight deals from South Carolina to Italy

Cheapest flights from South Carolina to Italy
Explore the most affordable flight options available from South Carolina to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/36:50 pm
CLT
-
MXP
1 stop11h 45m
Lufthansa
Tue 3/106:05 am
MXP
-
CLT
1 stop16h 50m
Lufthansa
Deal found 2/2$458
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/119:20 am
CLT
-
VCE
2 stops17h 50m
Multiple Airlines
Wed 8/196:30 am
VCE
-
CLT
1 stop16h 15m
Multiple Airlines
Deal found 2/2$473
This Flighttix deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1811:10 am
CHS
-
MXP
2 stops40h 45m
Multiple Airlines
Wed 3/259:45 am
MXP
-
CHS
1 stop18h 45m
Multiple Airlines
Deal found 2/1$475
This Cheapflightsfares deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:40 pm
CLT
-
VCE
1 stop15h 55m
Lufthansa
Wed 8/196:30 am
VCE
-
CLT
1 stop16h 15m
Lufthansa
Deal found 2/2$475
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:40 pm
CLT
-
VCE
1 stop12h 05m
United Airlines
Thu 8/2712:20 pm
VCE
-
CLT
2 stops34h 47m
United Airlines
Deal found 2/1$478
This Cheapflightsfares deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:47 pm
CLT
-
VCE
2 stops14h 48m
Lufthansa
Thu 8/206:30 am
VCE
-
CLT
1 stop16h 15m
Lufthansa
Deal found 2/1$479
This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/37:50 am
CLT
-
MXP
2 stops22h 45m
Multiple Airlines
Tue 3/109:50 am
MXP
-
CLT
1 stop13h 05m
Multiple Airlines
Deal found 2/1$482
This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:50 am
CLT
-
MXP
2 stops20h 05m
Multiple Airlines
Tue 3/106:05 am
MXP
-
CLT
1 stop16h 50m
Multiple Airlines
Deal found 2/1$484
This Cheapflightsfares deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/97:50 pm
CLT
-
MXP
1 stop15h 50m
Lufthansa
Tue 3/179:50 am
MXP
-
CLT
1 stop13h 05m
Lufthansa
Deal found 2/1$486
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/42:20 pm
CLT
-
MXP
1 stop11h 10m
United Airlines
Tue 2/101:05 pm
MXP
-
CLT
2 stops34h 19m
United Airlines
Deal found 2/1$487
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1210:40 am
CLT
-
MXP
1 stop20h 40m
United Airlines
Fri 8/2812:20 pm
MXP
-
CLT
2 stops37h 59m
United Airlines
Deal found 2/2$488
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/411:15 am
CHS
-
MXP
2 stops16h 40m
Multiple Airlines
Wed 3/116:55 am
MXP
-
CHS
2 stops19h 02m
Multiple Airlines
Deal found 2/2$490

Find flight deals from South Carolina to Italy

Keep the following information in mind while searching for South Carolina to Italy flight deals. Data was last updated February 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$458
(Kiwi.com)

One-way from

$251
(Kiwi.com)

Popular in

June

Cheapest in

January

Average price

$844
Provider with most accurate pricing for Myrtle Beach Intl-Rome (ROM) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Rome (ROM) flights.
Search Deals
From South Carolina to Italy
Search Deals
One-way flight from South Carolina to Italy
Search Deals
Highest demand for flights based on searches. 28% potential increase in price ($428 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($67 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from South Carolina to Italy that are best for you.

Fly from

South Carolina

Fly to

Italy

Route

Depart

Return

Price

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Mon 3/9

7:50 pm-4:40 pm

1 stop15h 50m

Milan Malpensa

Tue 3/17

9:50 am-5:55 pm

1 stop13h 05m

$486

GreenvilleRome

GSP - FCO

GSPFCO

Greenville

Mon 3/2

2:51 pm-8:30 am

1 stop11h 39m

Rome Fiumicino

Mon 3/9

10:15 am-8:51 pm

2 stops39h 36m

$494

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Wed 3/4

12:02 pm-10:35 am

2 stops16h 33m

Milan Malpensa

Wed 3/11

10:05 am-7:34 pm

1 stop14h 29m

$497

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Thu 3/19

12:44 pm-10:35 am

2 stops16h 51m

Milan Malpensa

Thu 3/26

10:05 am-12:16 am

1 stop19h 11m

$497

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Thu 3/19

12:44 pm-10:35 am

2 stops16h 51m

Milan Malpensa

Tue 3/24

11:00 am-9:24 pm

1 stop15h 24m

$497

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Sun 2/8

7:01 am-7:30 am

1 stop18h 29m

Milan Malpensa

Tue 2/24

9:45 am-4:29 pm

1 stop12h 44m

$498

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Mon 3/16

12:29 pm-8:05 am

1 stop14h 36m

Milan Malpensa

Wed 3/25

6:55 am-9:24 pm

2 stops19h 29m

$504

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Wed 3/4

9:54 am-9:05 am

1 stop17h 11m

Milan Malpensa

Tue 3/10

11:00 am-10:38 pm

1 stop16h 38m

$507

CharlestonRome

CHS - FCO

CHSFCO

Charleston

Mon 3/9

7:47 pm-8:30 am

1 stop31h 43m

Rome Fiumicino

Wed 3/18

7:05 am-8:57 pm

2 stops18h 52m

$508

CharlestonRome

CHS - FCO

CHSFCO

Charleston

Mon 3/9

12:46 pm-7:45 am

1 stop13h 59m

Rome Fiumicino

Tue 3/17

7:05 am-7:00 pm

2 stops16h 55m

$508

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/31

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Italy

What is the cheapest month to book a flight from South Carolina to Italy?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $181). Flying from South Carolina to Italy in July is currently the most expensive (average of $775). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IT?

Find hourly flight availability from South Carolina to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 3, 2026.

One of the essential ways to save on airfare from South Carolina to Italy is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 33% on airfare.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Italy?

    For as low as $494, Lufthansa can have you in Italy from South Carolina in 11h 39m. The distance from South Carolina to Italy is about 4869 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from South Carolina to Italy that include hotel bookings?

    Yes. In addition to deals on South Carolina to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Italy.

  • Can I find deals for business class flights from South Carolina to Italy?

    Yes. Cheapflights offers flight deals from South Carolina to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Italy?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $181). Flying from South Carolina to Italy in July is currently the most expensive (average of $775). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Italy

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from South Carolina to Italy

Discover the top 6 airlines that operate flights from South Carolina to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$307Average$1,096FlexibilityNo cancel feeOn-time69%
DeltaCheapest$457Average$1,122FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$507Average$1,012FlexibilityNo cancel feeOn-time75%
LufthansaCheapest$591Average$1,119FlexibilityNo cancel feeOn-time76%
British AirwaysCheapest$609Average$931FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$674Average$1,119FlexibilityNo cancel feeOn-time71%

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