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Italy

$267+ Cheap flights from South Carolina to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/22. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — NAP
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from South Carolina to Italy

Cheapest flights from South Carolina to Italy
Explore the most affordable flight options available from South Carolina to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This Gotogate deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/119:20 am
CLT
-
VCE
2 stops17h 50m
Multiple Airlines
Thu 8/209:55 am
VCE
-
CLT
1 stop12h 50m
Multiple Airlines
Deal found 1/26$472
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/236:50 pm
CLT
-
MXP
1 stop11h 45m
Lufthansa
Mon 3/25:25 pm
MXP
-
CLT
1 stop29h 30m
Lufthansa
Deal found 1/26$473
This Cheapflightsfares deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:40 pm
CLT
-
VCE
1 stop15h 55m
Lufthansa
Thu 8/209:55 am
VCE
-
CLT
1 stop12h 50m
Lufthansa
Deal found 1/26$473
This Cheapflightsfares deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:40 pm
CLT
-
VCE
1 stop15h 55m
Lufthansa
Fri 8/216:30 am
VCE
-
CLT
1 stop16h 15m
Lufthansa
Deal found 1/27$474
This Gotogate deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:00 am
CHS
-
MXP
2 stops21h 55m
Air Canada
Tue 3/31:05 pm
MXP
-
CHS
2 stops31h 44m
Air Canada
Deal found 1/27$475
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:40 pm
CLT
-
VCE
1 stop15h 55m
United Airlines
Thu 8/2712:20 pm
VCE
-
CLT
2 stops41h 09m
United Airlines
Deal found 1/26$476
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:00 am
CLT
-
VCE
1 stop19h 55m
United Airlines
Fri 8/2112:20 pm
VCE
-
CLT
2 stops30h 13m
United Airlines
Deal found 1/27$478
This Cheapflightsfares deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/97:50 pm
CLT
-
MXP
1 stop15h 50m
Lufthansa
Tue 3/176:05 am
MXP
-
CLT
1 stop16h 50m
Lufthansa
Deal found 1/26$485
This Mytrip deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:50 am
CLT
-
MXP
2 stops20h 05m
Multiple Airlines
Thu 3/129:50 am
MXP
-
CLT
1 stop13h 05m
Multiple Airlines
Deal found 1/27$486
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/11:50 pm
CLT
-
MXP
1 stop11h 40m
United Airlines
Tue 2/101:05 pm
MXP
-
CLT
2 stops31h 08m
United Airlines
Deal found 1/27$487
This Mytrip deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/95:05 pm
CLT
-
MXP
2 stops18h 35m
Multiple Airlines
Tue 3/176:05 am
MXP
-
CLT
1 stop16h 50m
Multiple Airlines
Deal found 1/27$488
This Cheapflightsfares deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/97:50 pm
CLT
-
LIN
1 stop18h 00m
Lufthansa
Tue 3/179:45 am
LIN
-
CLT
1 stop13h 10m
Lufthansa
Deal found 1/27$489

Find flight deals from South Carolina to Italy

Keep the following information in mind while searching for South Carolina to Italy flight deals. Data was last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$473
(Kiwi.com)

One-way from

$267
(Kiwi.com)

Popular in

June

Cheapest in

January

Average price

$519
Provider with most accurate pricing for Myrtle Beach Intl-Rome (ROM) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Rome (ROM) flights.
Search Deals
From South Carolina to Italy
Search Deals
One-way flight from South Carolina to Italy
Search Deals
Highest demand for flights based on searches. 28% potential increase in price ($425 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($67 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from South Carolina to Italy that are best for you.

Fly from

South Carolina

Fly to

Italy

Route

Depart

Return

Price

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Tue 2/24

6:00 am-9:55 am

2 stops21h 55m

Milan Malpensa

Tue 3/3

1:05 pm-2:49 pm

2 stops31h 44m

$475

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Tue 2/24

1:04 pm-9:05 am

1 stop14h 01m

Milan Malpensa

Tue 3/3

11:05 am-9:02 pm

1 stop15h 57m

$492

CharlestonRome

CHS - FCO

CHSFCO

Charleston

Mon 2/23

2:48 pm-8:30 am

1 stop11h 42m

Rome Fiumicino

Mon 3/2

11:15 am-9:27 pm

2 stops40h 12m

$493

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Wed 2/25

6:00 am-9:55 am

2 stops21h 55m

Milan Malpensa

Sun 3/1

11:40 am-10:09 am

2 stops28h 29m

$497

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Mon 2/9

2:25 pm-9:05 am

1 stop12h 40m

Milan Malpensa

Wed 2/25

12:00 pm-10:30 pm

1 stop16h 30m

$503

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Tue 2/17

9:54 am-9:05 am

1 stop17h 11m

Milan Malpensa

Tue 2/24

11:05 am-7:09 pm

1 stop14h 04m

$507

GreenvilleRome

GSP - FCO

GSPFCO

Greenville

Wed 2/25

10:00 am-8:30 am

1 stop16h 30m

Rome Fiumicino

Sun 3/1

9:45 am-8:41 pm

1 stop16h 56m

$508

GreenvilleRome

GSP - FCO

GSPFCO

Greenville

Mon 3/9

8:30 am-9:30 am

1 stop20h 00m

Rome Fiumicino

Wed 3/18

9:05 am-9:52 pm

1 stop17h 47m

$508

GreenvilleRome

GSP - FCO

GSPFCO

Greenville

Mon 3/9

8:30 am-9:30 am

1 stop20h 00m

Rome Fiumicino

Wed 3/18

6:10 am-7:37 pm

2 stops18h 27m

$510

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Sat 3/7

4:55 pm-10:45 am

2 stops35h 50m

Milan Malpensa

Mon 3/16

9:10 am-2:54 pm

2 stops34h 44m

$515

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Italy

What is the cheapest month to book a flight from South Carolina to Italy?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $181). Flying from South Carolina to Italy in July is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IT?

Find hourly flight availability from South Carolina to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 28, 2026.

One of the essential ways to save on airfare from South Carolina to Italy is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 33% on airfare.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Italy?

    For as low as $493, Air Canada can have you in Italy from South Carolina in 11h 42m. The distance from South Carolina to Italy is about 4855 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to Italy one-way?

    $298 is the cheapest one-way deal found within the past few days, from Neos Air. You may also be able to find cheap deals on Air France and Aeromexico, with prices starting from $369 and $381, respectively.

  • Can I find deals for flights from South Carolina to Italy that include hotel bookings?

    Yes. In addition to deals on South Carolina to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Italy.

  • Can I find deals for business class flights from South Carolina to Italy?

    Yes. Cheapflights offers flight deals from South Carolina to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Italy?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $181). Flying from South Carolina to Italy in July is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Italy

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Heathrow flights
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Top 6 airlines flying from South Carolina to Italy

Discover the top 6 airlines that operate flights from South Carolina to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$307Average$1,103FlexibilityNo cancel feeOn-time69%
DeltaCheapest$457Average$1,375FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$507Average$1,012FlexibilityNo cancel feeOn-time75%
LufthansaCheapest$591Average$1,119FlexibilityNo cancel feeOn-time76%
British AirwaysCheapest$609Average$949FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$674Average$1,119FlexibilityNo cancel feeOn-time71%

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