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$225+ Cheap flights from South Carolina to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/16. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — NAP
feb. 14 — feb. 211
sáb. 2/14
sáb. 2/21
1 adult, Economy
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Cheap flight deals from South Carolina to Italy

Keep the following information in mind while searching for South Carolina to Italy flight deals. Data was last updated enero 15, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$417
(oojo)

One-way from

$225
(oojo)

Popular in

June

Cheapest in

January

Average price

$519
Provider with most accurate pricing for Myrtle Beach Intl-Rome (ROM) flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Rome (ROM) flights.
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From South Carolina to Italy
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One-way flight from South Carolina to Italy
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Highest demand for flights based on searches. 28% potential increase in price ($424 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($67 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from South Carolina to Italy

Cheapest flights from South Carolina to Italy
Explore the most affordable flight options available from South Carolina to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 15, 2026.

This oojo deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/97:05 pm
CLT
-
MXP
2 stops19h 45m
British Airways
mar. 3/1710:25 am
MXP
-
CLT
1 stop15h 35m
British Airways
Deal found 1/13$417
This Air Canada deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/247:50 am
CLT
-
MXP
2 stops20h 05m
Air Canada
mar. 3/31:05 pm
MXP
-
CLT
2 stops37h 56m
Air Canada
Deal found 1/15$425
This American Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 2/98:25 pm
CLT
-
MXP
1 stop17h 25m
American Airlines
mié. 2/2510:25 am
MXP
-
CLT
1 stop29h 14m
American Airlines
Deal found 1/15$429
This United Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/95:30 pm
CLT
-
MXP
2 stops34h 25m
United Airlines
mar. 3/1712:05 pm
MXP
-
CLT
2 stops34h 17m
United Airlines
Deal found 1/14$430
This oojo deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/103:45 pm
CLT
-
VCE
2 stops23h 40m
British Airways
mar. 2/176:55 am
VCE
-
CLT
2 stops22h 30m
British Airways
Deal found 1/13$431
This oojo deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/97:05 pm
CLT
-
LIN
2 stops15h 35m
British Airways
mar. 3/174:30 pm
LIN
-
CLT
2 stops25h 34m
British Airways
Deal found 1/13$433
This American Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/246:25 pm
CLT
-
MXP
1 stop19h 20m
American Airlines
mar. 3/310:25 am
MXP
-
CLT
1 stop17h 11m
American Airlines
Deal found 1/15$433
This oojo deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 2/95:25 pm
CLT
-
LIN
2 stops16h 55m
British Airways
lun. 2/165:15 pm
LIN
-
CLT
2 stops49h 55m
British Airways
Deal found 1/13$438
This oojo deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 3/87:05 pm
CLT
-
MXP
2 stops34h 40m
British Airways
lun. 3/168:50 pm
MXP
-
CLT
2 stops30h 01m
British Airways
Deal found 1/13$438
This British Airways deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 2/84:48 pm
CLT
-
MXP
2 stops21h 12m
British Airways
mié. 2/1810:25 am
MXP
-
CLT
1 stop32h 39m
British Airways
Deal found 1/14$439
This American Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 1/258:25 pm
CLT
-
VCE
1 stop14h 30m
Multiple Airlines
mar. 2/106:20 am
VCE
-
CLT
1 stop15h 45m
Multiple Airlines
Deal found 1/15$439
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/183:25 pm
CLT
-
VCE
2 stops15h 55m
American Airlines
vie. 2/276:20 am
VCE
-
CLT
1 stop16h 00m
American Airlines
Deal found 1/14$443

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 15, 2026.
Use the filters below to find and compare flights from South Carolina to Italy that are best for you.

Fly from

South Carolina

Fly to

Italy

Route

Depart

Return

Price

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

lun. 2/9

6:37 pm-7:50 pm

2 stops19h 13m

Milan Malpensa

mié. 2/25

10:25 am-9:00 pm

1 stop16h 35m

$430

CharlotteVenice

CLT - VCE

CLTVCE

Charlotte Douglas

mar. 2/10

3:45 pm-9:25 pm

2 stops23h 40m

Venice Marco Polo

mar. 2/17

6:55 am-11:25 pm

2 stops22h 30m

$431

CharlotteMilan

CLT - LIN

CLTLIN

Charlotte Douglas

lun. 3/9

7:05 pm-3:40 pm

2 stops15h 35m

Milan Linate

mar. 3/17

4:30 pm-1:04 pm

2 stops25h 34m

$433

CharlotteVenice

CLT - VCE

CLTVCE

Charlotte Douglas

dom. 1/25

8:25 pm-4:55 pm

1 stop14h 30m

Venice Marco Polo

mar. 2/10

6:20 am-4:05 pm

1 stop15h 45m

$439

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

dom. 2/8

4:48 pm-8:00 pm

2 stops21h 12m

Milan Malpensa

mié. 2/18

10:25 am-1:04 pm

1 stop32h 39m

$439

CharlotteMilan

CLT - LIN

CLTLIN

Charlotte Douglas

lun. 2/9

8:25 pm-3:40 pm

1 stop13h 15m

Milan Linate

lun. 2/16

5:15 pm-1:55 pm

1 stop26h 40m

$445

CharlotteMilan

CLT - LIN

CLTLIN

Charlotte Douglas

lun. 3/9

7:20 pm-4:20 pm

1 stop16h 00m

Milan Linate

mar. 3/17

6:55 pm-2:55 pm

1 stop25h 00m

$445

CharlotteMilan

CLT - LIN

CLTLIN

Charlotte Douglas

dom. 3/8

6:30 pm-4:20 pm

2 stops16h 50m

Milan Linate

lun. 3/16

4:35 pm-1:52 pm

2 stops50h 17m

$446

CharlotteVenice

CLT - VCE

CLTVCE

Charlotte Douglas

dom. 1/25

6:30 pm-1:20 pm

1 stop12h 50m

Venice Marco Polo

mar. 2/10

6:55 am-4:53 pm

2 stops15h 58m

$449

CharlestonRome

CHS - FCO

CHSFCO

Charleston

lun. 1/26

12:53 pm-9:45 am

2 stops14h 52m

Rome Fiumicino

mar. 2/10

12:40 pm-11:55 pm

1 stop17h 15m

$456

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/13

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Italy

What is the cheapest month to book a flight from South Carolina to Italy?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $169). Flying from South Carolina to Italy in July is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IT?

Find hourly flight availability from South Carolina to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated enero 15, 2026.

One of the essential ways to save on airfare from South Carolina to Italy is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 33% on airfare.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Italy?

    For as low as $445, British Airways can have you in Italy from South Carolina in 13h 15m. The distance from South Carolina to Italy is about 4548 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to Italy one-way?

    $192 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on United Airlines and Delta, with prices starting from $281 and $303, respectively.

  • Can I find deals for flights from South Carolina to Italy that include hotel bookings?

    Yes. In addition to deals on South Carolina to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Italy.

  • Can I find deals for business class flights from South Carolina to Italy?

    Yes. Cheapflights offers flight deals from South Carolina to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Italy?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $169). Flying from South Carolina to Italy in July is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Italy

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from South Carolina to Italy

Discover the top 7 airlines that operate flights from South Carolina to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$307Average$1,090FlexibilityNo cancel feeOn-time69%
KLMCheapest$507Average$1,053FlexibilityNo cancel feeOn-time75%
DeltaCheapest$507Average$1,194FlexibilityNo cancel feeOn-timeN/A
LufthansaCheapest$591Average$1,196FlexibilityNo cancel feeOn-time76%
British AirwaysCheapest$609Average$951FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$674Average$1,192FlexibilityNo cancel feeOn-time71%
Air FranceCheapest$957Average$1,308FlexibilityNo cancel feeOn-time77%

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