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Italy

$328+ Cheap flights from South Carolina to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/24. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — NAP
May 10 — May 171
Sun 5/10
Sun 5/17
1 adult, Economy
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Cheap flight deals from South Carolina to Italy

Cheapest flights from South Carolina to Italy
Explore the most affordable flight options available from South Carolina to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 10, 2026.

This lol.travel deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lol.travel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/198:10 am
CLT
-
MXP
1 stop18h 55m
Finnair
Tue 5/511:00 am
MXP
-
CLT
1 stop16h 52m
Finnair
Deal found 4/6$670
This Cheapflightsfares deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:40 pm
CLT
-
VCE
1 stop12h 05m
Lufthansa
Wed 8/196:30 am
VCE
-
CLT
1 stop16h 15m
Lufthansa
Deal found 4/6$674
This Cheapflightsfares deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1810:23 am
CLT
-
VCE
2 stops24h 12m
Lufthansa
Tue 8/256:30 am
VCE
-
CLT
1 stop16h 15m
Lufthansa
Deal found 4/5$678
This eDestinos deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/611:26 am
CLT
-
MXP
1 stop15h 39m
Iberia
Wed 5/1311:00 am
MXP
-
CLT
1 stop16h 52m
Iberia
Deal found 4/6$686
This Cheapflightsfares deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:50 pm
CLT
-
LIN
1 stop18h 00m
Lufthansa
Thu 11/129:45 am
LIN
-
CLT
1 stop13h 10m
Lufthansa
Deal found 4/5$689
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3011:55 am
CHS
-
MXP
1 stop19h 10m
United Airlines
Sun 12/131:05 pm
MXP
-
CHS
2 stops32h 19m
United Airlines
Deal found 4/5$692
This Cheapflightsfares deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:50 pm
CLT
-
MXP
1 stop15h 50m
Lufthansa
Thu 11/122:40 pm
MXP
-
CLT
2 stops16h 10m
Lufthansa
Deal found 4/5$693
This Air Canada deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:00 am
CHS
-
MXP
2 stops21h 55m
Air Canada
Fri 12/111:05 pm
MXP
-
CHS
2 stops32h 19m
Air Canada
Deal found 4/5$695
This Air Canada deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/111:55 am
CHS
-
MXP
2 stops16h 00m
Air Canada
Sun 12/131:05 pm
MXP
-
CHS
3 stops32h 19m
Air Canada
Deal found 4/5$700
This Cheapflightsfares deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/128:05 am
CLT
-
VCE
2 stops19h 30m
SWISS
Wed 8/197:40 pm
VCE
-
CLT
2 stops27h 05m
SWISS
Deal found 4/6$701
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:25 pm
CLT
-
VCE
1 stop19h 05m
American Airlines
Wed 11/116:20 am
VCE
-
CLT
1 stop15h 50m
American Airlines
Deal found 4/8$702
This British Airways deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/111:04 pm
CLT
-
FLR
2 stops16h 31m
Multiple Airlines
Fri 8/217:05 am
FLR
-
CLT
2 stops18h 03m
Multiple Airlines
Deal found 4/9$709

Find flight deals from South Carolina to Italy

Keep the following information in mind while searching for South Carolina to Italy flight deals. Data was last updated April 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$674
(Cheapflightsfares)

One-way from

$328
(British Airways)

Popular in

June

Cheapest in

January

Average price

$1,216
Provider with most accurate pricing for Myrtle Beach Intl-Rome (ROM) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Rome (ROM) flights.
Search Deals
From South Carolina to Italy
Search Deals
One-way flight from South Carolina to Italy
Search Deals
Highest demand for flights based on searches. 28% potential increase in price ($459 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($98 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
Use the filters below to find and compare flights from South Carolina to Italy that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteVenice

CLT - VCE

CLTVCE

Charlotte Douglas

Wed 8/12

11:45 am-8:55 am

1 stop15h 10m

Venice Marco Polo

Wed 8/19

11:05 am-8:23 pm

1 stop15h 18m

$713

CharlotteFlorence

CLT - FLR

CLTFLR

Charlotte Douglas

Sun 8/16

1:04 pm-11:50 am

2 stops16h 46m

Florence Peretola

Thu 8/27

7:05 am-7:17 pm

2 stops18h 12m

$726

CharlotteFlorence

CLT - FLR

CLTFLR

Charlotte Douglas

Tue 8/11

1:04 pm-11:35 am

2 stops16h 31m

Florence Peretola

Fri 8/21

7:05 am-7:08 pm

2 stops18h 03m

$726

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Mon 8/10

2:35 pm-7:30 am

1 stop10h 55m

Milan Malpensa

Tue 8/18

10:40 am-9:30 pm

2 stops40h 50m

$731

CharlestonRome

CHS - FCO

CHSFCO

Charleston

Wed 10/7

4:00 pm-9:20 am

2 stops35h 20m

Rome Fiumicino

Mon 10/12

11:00 am-11:25 am

2 stops30h 25m

$754

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Tue 5/5

5:28 pm-1:20 pm

1 stop13h 52m

Milan Malpensa

Wed 5/13

12:20 pm-1:42 pm

2 stops31h 22m

$761
Quickest round-trip

CharlotteFlorence

CLT - FLR

CLTFLR

Charlotte Douglas

Tue 8/11

6:40 pm-12:40 pm

1 stop12h 00m

Florence Peretola

Fri 8/21

9:50 am-4:45 pm

1 stop12h 55m

$770

CharlotteFlorence

CLT - FLR

CLTFLR

Charlotte Douglas

Mon 8/17

6:00 am-11:00 am

2 stops23h 00m

Florence Peretola

Fri 8/21

9:50 am-4:45 pm

1 stop12h 55m

$775

CharlotteFlorence

CLT - FLR

CLTFLR

Charlotte Douglas

Sun 8/16

10:23 am-12:40 pm

2 stops20h 17m

Florence Peretola

Thu 8/27

9:50 am-4:45 pm

1 stop12h 55m

$775

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Wed 5/6

11:26 am-9:05 am

1 stop15h 39m

Milan Malpensa

Wed 5/13

11:00 am-9:52 pm

1 stop16h 52m

$781

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/9

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from South Carolina to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Italy

What is the cheapest month to book a flight from South Carolina to Italy?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $192). Flying from South Carolina to Italy in July is currently the most expensive (average of $760). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IT?

Find hourly flight availability from South Carolina to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 10, 2026.

One of the essential ways to save on airfare from South Carolina to Italy is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 33% on airfare.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Italy?

    For as low as $713, KLM can have you in Italy from South Carolina in 15h 10m. The distance from South Carolina to Italy is about 4678 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to Italy one-way?

    $411 is the cheapest one-way deal found within the past few days, from United Airlines. You may also be able to find cheap deals on American Airlines and Delta, with prices starting from $442 and $518, respectively.

  • Can I find deals for flights from South Carolina to Italy that include hotel bookings?

    Yes. In addition to deals on South Carolina to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Italy.

  • Can I find deals for business class flights from South Carolina to Italy?

    Yes. Cheapflights offers flight deals from South Carolina to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Italy?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $192). Flying from South Carolina to Italy in July is currently the most expensive (average of $760). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Italy

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from South Carolina to Italy

Discover the top 6 airlines that operate flights from South Carolina to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$307Average$1,088FlexibilityNo cancel feeOn-time69%
British AirwaysCheapest$468Average$880FlexibilityNo cancel feeOn-time70%
DeltaCheapest$503Average$1,105FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$625Average$945FlexibilityNo cancel feeOn-time75%
American AirlinesCheapest$699Average$1,149FlexibilityNo cancel feeOn-time71%
LufthansaCheapest$745Average$1,380FlexibilityNo cancel feeOn-time76%

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