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Italy

$222+ Cheap flights from South Carolina to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/13. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — NAP
Dec 12 — Dec 191
Fri 12/12
Fri 12/19
1 adult, Economy
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Find flight deals from South Carolina to Italy

Cheapest flights from South Carolina to Italy
Explore the most affordable flight options available from South Carolina to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:50 pmCLT - MXP
1 stop15h 50mLufthansa
Thu 12/46:55 amMXP - CLT
2 stops17h 55mLufthansa
Deal found 11/11$447
This lastminute.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lastminute.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:00 amCLT - MXP
2 stops21h 55mAir Canada
Thu 12/251:05 pmMXP - CLT
2 stops38h 15mAir Canada
Deal found 11/11$458
This Mytrip deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:25 pmCLT - FCO
2 stops14h 00mBritish Airways
Tue 12/911:00 amFCO - CLT
1 stop14h 38mBritish Airways
Deal found 11/11$469
This Mytrip deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/249:30 amCLT - MXP
2 stops18h 25mMultiple Airlines
Thu 12/46:55 amMXP - CLT
2 stops20h 02mMultiple Airlines
Deal found 11/10$475
This Mytrip deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/235:05 pmCLT - MXP
2 stops34h 50mAir Canada
Tue 12/910:40 amMXP - CLT
2 stops16h 17mAir Canada
Deal found 11/11$476
This Booking.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/235:05 pmCLT - MXP
2 stops34h 50mMultiple Airlines
Tue 12/99:50 amMXP - CLT
1 stop13h 05mMultiple Airlines
Deal found 11/11$478
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:45 amCHS - MXP
1 stop18h 45mUnited Airlines
Mon 1/129:45 amMXP - CHS
1 stop30h 05mUnited Airlines
Deal found 11/10$483
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/247:04 amCLT - MXP
2 stops20h 51mUnited Airlines
Thu 12/41:05 pmMXP - CLT
2 stops38h 34mUnited Airlines
Deal found 11/10$483
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:50 pmCLT - MXP
1 stop15h 50mUnited Airlines
Tue 12/161:05 pmMXP - CLT
2 stops31h 06mUnited Airlines
Deal found 11/11$484
This Air Canada deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/75:05 pmCLT - MXP
2 stops34h 50mAir Canada
Tue 12/161:05 pmMXP - CLT
2 stops31h 06mAir Canada
Deal found 11/11$485
This Mytrip deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:50 pmCLT - LIN
1 stop18h 00mMultiple Airlines
Thu 12/46:00 amLIN - CLT
2 stops20h 57mMultiple Airlines
Deal found 11/10$488
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/82:51 pmCHS - FCO
1 stop11h 39mUnited Airlines
Mon 12/1510:55 amFCO - CHS
2 stops38h 35mUnited Airlines
Deal found 11/9$489

Cheap flight deals from South Carolina to Italy

Keep the following information in mind while searching for South Carolina to Italy flight deals. Data was last updated November 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$447
(Kiwi.com)

One-way from

$222
(Kiwi.com)

Popular in

June

Cheapest in

November

Average price

$720
Provider with most accurate pricing for Myrtle Beach Intl-Rome (ROM) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Rome (ROM) flights.
Search Deals
From South Carolina to Italy
Search Deals
One-way flight from South Carolina to Italy
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($408 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($74 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
Use the filters below to find and compare flights from South Carolina to Italy that are best for you.

Fly from

South Carolina

Fly to

Italy

Route

Depart

Return

Price

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Mon 12/29

6:45 am-7:30 am

1 stop18h 45m

Milan Malpensa

Mon 1/12

9:45 am-7:04 pm

2 stops15h 19m

$483

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Mon 12/8

6:30 am-9:55 am

2 stops21h 25m

Milan Malpensa

Tue 12/16

1:05 pm-2:11 pm

2 stops31h 06m

$483

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Mon 11/24

7:04 am-9:55 am

2 stops20h 51m

Milan Malpensa

Thu 12/4

1:05 pm-9:39 pm

2 stops38h 34m

$483

SavannahRome

SAV - FCO

SAVFCO

Savannah/Hilton Head

Sat 1/31

2:05 pm-7:55 am

1 stop11h 50m

Rome Fiumicino

Mon 2/9

11:15 am-7:25 pm

2 stops38h 10m

$483

CharlestonRome

CHS - FCO

CHSFCO

Charleston

Mon 12/8

2:51 pm-8:30 am

1 stop11h 39m

Rome Fiumicino

Mon 12/15

10:55 am-7:30 pm

2 stops38h 35m

$489

SavannahRome

SAV - FCO

SAVFCO

Savannah/Hilton Head

Fri 1/30

7:19 pm-8:30 am

1 stop31h 11m

Rome Fiumicino

Sun 2/8

12:45 pm-10:46 pm

2 stops40h 01m

$490

CharlestonRome

CHS - FCO

CHSFCO

Charleston

Thu 1/15

2:58 pm-9:25 am

2 stops36h 27m

Rome Fiumicino

Tue 1/20

7:05 am-5:59 pm

2 stops16h 54m

$494

CharlestonRome

CHS - FCO

CHSFCO

Charleston

Thu 1/15

7:45 pm-9:25 am

2 stops31h 40m

Rome Fiumicino

Mon 1/19

1:30 pm-7:04 pm

2 stops35h 34m

$495

CharlotteMilan

CLT - LIN

CLTLIN

Charlotte Douglas

Mon 11/24

6:50 pm-6:50 pm

1 stop18h 00m

Milan Linate

Thu 12/4

9:45 am-4:55 pm

1 stop13h 10m

$497

CharlestonRome

CHS - FCO

CHSFCO

Charleston

Thu 1/15

7:00 pm-10:30 am

1 stop33h 30m

Rome Fiumicino

Tue 1/20

12:40 pm-11:58 pm

1 stop17h 18m

$498

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/10

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Italy

What is the cheapest month to book a flight from South Carolina to Italy?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $181). Flying from South Carolina to Italy in July is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IT?

Find hourly flight availability from South Carolina to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 12, 2025.

One of the essential ways to save on airfare from South Carolina to Italy is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 11% on airfare.

What is the cheapest day to fly from South Carolina to Italy?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Italy. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to Italy flight should consider departing on Sunday mornings when fares are most often at their lowest. Saturday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Italy?

    For as low as $497, United Airlines can have you in Italy from South Carolina in 18h. The distance from South Carolina to Italy is about 4548 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to Italy one-way?

    $300 is the cheapest one-way deal found within the past few days, from KLM. You may also be able to find cheap deals on United Airlines and Lufthansa, with prices starting from $317 and $348, respectively.

  • Can I find deals for flights from South Carolina to Italy that include hotel bookings?

    Yes. In addition to deals on South Carolina to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Italy.

  • Can I find deals for business class flights from South Carolina to Italy?

    Yes. Cheapflights offers flight deals from South Carolina to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Italy?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $181). Flying from South Carolina to Italy in July is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 7 airlines flying from South Carolina to Italy

Discover the top 7 airlines that operate flights from South Carolina to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$307Average$1,062FlexibilityNo cancel feeOn-time69%
DeltaCheapest$547Average$1,197FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$555Average$1,075FlexibilityNo cancel feeOn-time75%
American AirlinesCheapest$628Average$1,193FlexibilityNo cancel feeOn-time71%
LufthansaCheapest$635Average$1,212FlexibilityNo cancel feeOn-time76%
British AirwaysCheapest$674Average$1,038FlexibilityNo cancel feeOn-time70%
Air FranceCheapest$957Average$1,308FlexibilityNo cancel feeOn-time77%

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