HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Italy

$242+ Cheap flights from South Carolina to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/4. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — NAP
Apr 9 — Apr 161
Thu 4/9
Thu 4/16
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from South Carolina to Italy with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from South Carolina to Italy

Cheapest flights from South Carolina to Italy
Explore the most affordable flight options available from South Carolina to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.

This FlightHub deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/97:50 pm
CLT
-
MXP
1 stop11h 45m
Lufthansa
Tue 3/179:50 am
MXP
-
CLT
1 stop13h 05m
Lufthansa
Deal found 3/9$509
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/112:59 pm
CLT
-
VCE
1 stop10h 56m
United Airlines
Thu 8/2012:20 pm
VCE
-
CLT
2 stops37h 54m
United Airlines
Deal found 3/9$543
This Air Canada deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:00 am
CLT
-
VCE
2 stops21h 10m
Air Canada
Thu 8/2012:20 pm
VCE
-
CLT
2 stops35h 24m
Air Canada
Deal found 3/9$546
This oojo deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/113:23 pm
CLT
-
VCE
2 stops20h 17m
British Airways
Fri 8/2112:15 pm
VCE
-
CLT
1 stop16h 19m
British Airways
Deal found 3/7$553
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1111:50 pm
CLT
-
VCE
1 stop14h 15m
American Airlines
Thu 8/2012:15 pm
VCE
-
CLT
1 stop18h 04m
American Airlines
Deal found 3/9$555
This Trip.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/139:20 am
CLT
-
MXP
2 stops19h 00m
Air Canada
Tue 1/191:05 pm
MXP
-
CLT
2 stops33h 14m
Air Canada
Deal found 3/8$558
This Air Canada deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/310:27 am
CLT
-
MXP
2 stops17h 53m
Air Canada
Thu 8/2012:20 pm
MXP
-
CLT
2 stops35h 24m
Air Canada
Deal found 3/7$560
This Air Canada deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/23:40 pm
CLT
-
MXP
2 stops36h 40m
Air Canada
Thu 8/2012:20 pm
MXP
-
CLT
2 stops42h 44m
Air Canada
Deal found 3/7$561
This FlightHub deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/296:50 pm
CLT
-
VCE
1 stop11h 55m
Lufthansa
Wed 12/92:50 pm
VCE
-
CLT
2 stops16h 00m
Lufthansa
Deal found 3/6$562
This Mytrip deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:50 pm
CLT
-
LIN
1 stop18h 00m
Multiple Airlines
Tue 1/2610:45 am
LIN
-
CLT
2 stops16h 14m
Multiple Airlines
Deal found 3/8$563
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1211:50 pm
CLT
-
VCE
1 stop13h 35m
American Airlines
Wed 8/199:05 pm
VCE
-
CLT
1 stop25h 00m
American Airlines
Deal found 3/5$563
This lol.travel deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lol.travel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:35 pm
CLT
-
LIN
2 stops15h 25m
Multiple Airlines
Tue 1/196:10 am
LIN
-
CLT
2 stops20h 49m
Multiple Airlines
Deal found 3/8$564

Find flight deals from South Carolina to Italy

Keep the following information in mind while searching for South Carolina to Italy flight deals. Data was last updated March 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$522
(Delta)

One-way from

$242
(Kiwi.com)

Popular in

June

Cheapest in

January

Average price

$916
Provider with most accurate pricing for Myrtle Beach Intl-Rome (ROM) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Rome (ROM) flights.
Search Deals
From South Carolina to Italy
Search Deals
One-way flight from South Carolina to Italy
Search Deals
Highest demand for flights based on searches. 29% potential increase in price ($467 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($102 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from South Carolina to Italy that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Tue 4/7

7:00 am-10:20 am

2 stops21h 20m

Milan Malpensa

Thu 4/23

3:20 pm-12:45 am

1 stop15h 25m

$607

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Tue 5/5

10:55 am-12:05 pm

1 stop19h 10m

Milan Malpensa

Tue 5/26

11:35 am-10:06 pm

1 stop16h 31m

$631

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Mon 3/23

5:18 pm-2:55 pm

2 stops16h 37m

Milan Malpensa

Mon 3/30

6:45 am-4:26 pm

2 stops15h 41m

$641

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Tue 4/14

7:30 pm-1:20 pm

2 stops35h 50m

Milan Malpensa

Tue 4/21

12:20 pm-5:24 pm

2 stops35h 04m

$649

CharlotteVenice

CLT - VCE

CLTVCE

Charlotte Douglas

Mon 3/16

3:25 pm-10:20 am

1 stop13h 55m

Venice Marco Polo

Tue 3/31

1:20 pm-2:45 pm

1 stop31h 25m

$654

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Tue 4/7

10:03 am-9:25 am

1 stop17h 22m

Milan Malpensa

Thu 4/23

11:40 am-8:16 pm

1 stop14h 36m

$654

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Sun 4/5

2:30 pm-9:25 am

1 stop12h 55m

Milan Malpensa

Thu 4/16

2:15 pm-10:49 pm

1 stop14h 34m

$673

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Tue 5/5

6:00 am-12:05 pm

1 stop24h 05m

Milan Malpensa

Tue 5/19

9:00 am-5:12 pm

1 stop14h 12m

$685

CharlestonMilan

CHS - LIN

CHSLIN

Charleston

Tue 5/5

3:10 pm-11:20 am

2 stops14h 10m

Milan Linate

Tue 5/19

6:40 am-5:12 pm

2 stops16h 32m

$690

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Thu 5/14

6:00 am-6:45 am

1 stop18h 45m

Milan Malpensa

Thu 5/21

11:35 am-10:06 pm

1 stop16h 31m

$691

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/4

Showing 1-10 of 60 resultsSorted by cheapest first
1
2
3
...
6

Best time to book a flight from South Carolina to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Italy

What is the cheapest month to book a flight from South Carolina to Italy?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $192). Flying from South Carolina to Italy in July is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IT?

Find hourly flight availability from South Carolina to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 10, 2026.

One of the essential ways to save on airfare from South Carolina to Italy is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 33% on airfare.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Italy?

    For as low as $631, United Airlines can have you in Italy from South Carolina in 19h 10m. The distance from South Carolina to Italy is about 4519 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to Italy one-way?

    $298 is the cheapest one-way deal found within the past few days, from Neos Air. You may also be able to find cheap deals on Air France and Iberia, with prices starting from $454 and $483, respectively.

  • Can I find deals for flights from South Carolina to Italy that include hotel bookings?

    Yes. In addition to deals on South Carolina to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Italy.

  • Can I find deals for business class flights from South Carolina to Italy?

    Yes. Cheapflights offers flight deals from South Carolina to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Italy?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $192). Flying from South Carolina to Italy in July is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Italy

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Heathrow flights
Newark to Heathrow flights
John F Kennedy Intl to Charles de Gaulle flights
Newark to Charles de Gaulle flights
John F Kennedy Intl to Leonardo da Vinci/Fiumicino flights
Newark to Leonardo da Vinci/Fiumicino flights
John F Kennedy Intl to Gatwick flights
Boston to Heathrow flights
John F Kennedy Intl to Lisbon flights
LaGuardia to Heathrow flights
John F Kennedy Intl to Athens flights
John F Kennedy Intl to Madrid flights
John F Kennedy Intl to London City flights
Newark to Athens flights
John F Kennedy Intl to Barcelona-El Prat flights
Newark to Gatwick flights
Dulles Intl to Heathrow flights
John F Kennedy Intl to Orly flights
John F Kennedy Intl to Dublin flights
Newark to Madrid flights
Newark to Lisbon flights
Newark to Dublin flights
Newark to Orly flights
Newark to Barcelona-El Prat flights
Los Angeles to Heathrow flights
O'Hare Intl to Leonardo da Vinci/Fiumicino flights
Boston to Charles de Gaulle flights
John F Kennedy Intl to Malpensa flights
Boston to Leonardo da Vinci/Fiumicino flights
John F Kennedy Intl to Istanbul flights
Newark to Malpensa flights
O'Hare Intl to Heathrow flights
Miami to Madrid flights
Dallas/Fort Worth to Heathrow flights
San Francisco to Heathrow flights
Baltimore to Heathrow flights
Seattle to Heathrow flights
John F Kennedy Intl to Frederic Chopin flights
LaGuardia to Gatwick flights
O'Hare Intl to Charles de Gaulle flights
Dulles Intl to Charles de Gaulle flights
Los Angeles to Charles de Gaulle flights
Boston to Gatwick flights
Dulles Intl to Leonardo da Vinci/Fiumicino flights
Boston to Dublin flights

Top 6 airlines flying from South Carolina to Italy

Discover the top 6 airlines that operate flights from South Carolina to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$307Average$1,088FlexibilityNo cancel feeOn-time69%
British AirwaysCheapest$468Average$894FlexibilityNo cancel feeOn-time70%
DeltaCheapest$503Average$1,161FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$507Average$1,012FlexibilityNo cancel feeOn-time75%
LufthansaCheapest$591Average$950FlexibilityNo cancel feeOn-time76%
American AirlinesCheapest$674Average$1,151FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.