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Italy

$300+ Cheap flights from South Carolina to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/11. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — NAP
Apr 23 — Apr 301
Thu 4/23
Thu 4/30
1 adult, Economy
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Cheap flight deals from South Carolina to Italy

Cheapest flights from South Carolina to Italy
Explore the most affordable flight options available from South Carolina to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 24, 2026.

This Cheapflightsfares deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:40 pm
CLT
-
VCE
1 stop12h 05m
Lufthansa
Wed 8/196:30 am
VCE
-
CLT
1 stop16h 15m
Lufthansa
Deal found 3/23$628
This Cheapflightsfares deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/111:05 pm
CLT
-
VCE
2 stops21h 30m
Lufthansa
Fri 8/216:30 am
VCE
-
CLT
1 stop16h 15m
Lufthansa
Deal found 3/21$632
This Trip.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/149:18 am
CLT
-
MXP
2 stops28h 32m
Multiple Airlines
Wed 4/229:20 am
MXP
-
CLT
2 stops19h 48m
Multiple Airlines
Deal found 3/19$639
This Cheapflightsfares deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:50 pm
CLT
-
MXP
1 stop15h 50m
Lufthansa
Fri 11/66:05 am
MXP
-
CLT
1 stop16h 50m
Lufthansa
Deal found 3/24$640
This Cheapflightsfares deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:50 pm
CLT
-
LIN
1 stop18h 00m
Lufthansa
Fri 11/69:30 am
LIN
-
CLT
1 stop13h 25m
Lufthansa
Deal found 3/24$643
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:40 pm
CLT
-
MXP
1 stop16h 00m
Lufthansa
Wed 4/2912:55 pm
MXP
-
CLT
2 stops16h 56m
Lufthansa
Deal found 3/23$647
This Trip.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:12 am
CLT
-
MXP
2 stops27h 13m
Multiple Airlines
Wed 5/135:50 am
MXP
-
CLT
2 stops23h 14m
Multiple Airlines
Deal found 3/19$649
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:40 pm
CLT
-
LIN
1 stop17h 05m
Lufthansa
Wed 4/291:40 pm
LIN
-
CLT
2 stops16h 11m
Lufthansa
Deal found 3/23$651
This Cheapflightsfares deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1210:23 am
CLT
-
MXP
2 stops18h 12m
Lufthansa
Wed 8/196:20 am
MXP
-
CLT
1 stop16h 25m
Lufthansa
Deal found 3/23$655
This Cheapflightsfares deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/128:05 am
CLT
-
VCE
2 stops28h 45m
SWISS
Wed 8/197:40 pm
VCE
-
CLT
2 stops27h 05m
SWISS
Deal found 3/23$655
This United Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1611:05 am
CLT
-
MXP
1 stop14h 25m
United Airlines
Fri 11/201:05 pm
MXP
-
CLT
2 stops32h 48m
United Airlines
Deal found 3/19$657
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:40 pm
CLT
-
LIN
1 stop12h 20m
Lufthansa
Tue 4/288:45 am
LIN
-
CLT
1 stop14h 00m
Lufthansa
Deal found 3/22$659

Find flight deals from South Carolina to Italy

Keep the following information in mind while searching for South Carolina to Italy flight deals. Data was last updated March 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$628
(Cheapflightsfares)

One-way from

$300
(Mytrip)

Popular in

June

Cheapest in

January

Average price

$916
Provider with most accurate pricing for Myrtle Beach Intl-Rome (ROM) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Rome (ROM) flights.
Search Deals
From South Carolina to Italy
Search Deals
One-way flight from South Carolina to Italy
Search Deals
Highest demand for flights based on searches. 29% potential increase in price ($464 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($102 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from South Carolina to Italy that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Sat 8/1

7:44 pm-4:40 pm

2 stops38h 56m

Milan Malpensa

Wed 8/26

12:20 pm-8:14 pm

2 stops37h 54m

$669

CharlotteFlorence

CLT - FLR

CLTFLR

Charlotte Douglas

Sun 8/16

1:04 pm-11:50 am

2 stops16h 46m

Florence Peretola

Thu 8/27

12:25 pm-11:59 pm

2 stops17h 34m

$684

CharlotteMilan

CLT - MXP

CLTMXP

Charlotte Douglas

Wed 4/8

11:09 am-1:20 pm

2 stops20h 11m

Milan Malpensa

Tue 4/14

12:20 pm-1:21 pm

2 stops31h 01m

$715

CharlotteMilan

CLT - LIN

CLTLIN

Charlotte Douglas

Wed 4/8

10:34 am-12:20 pm

2 stops19h 46m

Milan Linate

Wed 4/15

6:50 am-9:03 pm

2 stops20h 13m

$717

CharlotteMilan

CLT - LIN

CLTLIN

Charlotte Douglas

Mon 4/6

10:34 am-12:20 pm

2 stops19h 46m

Milan Linate

Wed 4/15

6:50 am-9:03 pm

2 stops20h 13m

$717

CharlotteMilan

CLT - LIN

CLTLIN

Charlotte Douglas

Wed 8/12

3:57 pm-12:00 pm

2 stops14h 03m

Milan Linate

Wed 8/19

6:50 am-4:45 pm

2 stops15h 55m

$726

CharlestonRome

CHS - FCO

CHSFCO

Charleston

Thu 4/16

11:18 am-2:10 pm

2 stops44h 52m

Rome Fiumicino

Mon 4/20

10:50 am-10:28 am

2 stops29h 38m

$754

CharlotteFlorence

CLT - FLR

CLTFLR

Charlotte Douglas

Mon 8/24

2:20 pm-7:05 pm

2 stops22h 45m

Florence Peretola

Thu 8/27

7:55 pm-10:02 pm

2 stops32h 07m

$778

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Fri 5/8

5:59 pm-11:45 pm

2 stops23h 46m

Milan Malpensa

Mon 5/25

6:50 am-6:12 pm

2 stops41h 22m

$779

CharlestonMilan

CHS - MXP

CHSMXP

Charleston

Sat 5/9

6:00 am-5:35 pm

2 stops29h 35m

Milan Malpensa

Mon 5/25

6:50 am-6:12 pm

2 stops41h 22m

$779

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/20

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from South Carolina to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Italy

What is the cheapest month to book a flight from South Carolina to Italy?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $192). Flying from South Carolina to Italy in July is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IT?

Find hourly flight availability from South Carolina to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 24, 2026.

One of the essential ways to save on airfare from South Carolina to Italy is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 33% on airfare.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Italy?

    For as low as $778, United Airlines can have you in Italy from South Carolina in 22h 45m. The distance from South Carolina to Italy is about 4684 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to Italy one-way?

    $192 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on United Airlines and Delta, with prices starting from $281 and $281, respectively.

  • Can I find deals for flights from South Carolina to Italy that include hotel bookings?

    Yes. In addition to deals on South Carolina to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Italy.

  • Can I find deals for business class flights from South Carolina to Italy?

    Yes. Cheapflights offers flight deals from South Carolina to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Italy?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Italy (average of $192). Flying from South Carolina to Italy in July is currently the most expensive (average of $772). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Italy

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from South Carolina to Italy

Discover the top 6 airlines that operate flights from South Carolina to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$307Average$1,113FlexibilityNo cancel feeOn-time69%
British AirwaysCheapest$468Average$894FlexibilityNo cancel feeOn-time70%
DeltaCheapest$503Average$1,104FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$507Average$1,012FlexibilityNo cancel feeOn-time75%
American AirlinesCheapest$699Average$1,145FlexibilityNo cancel feeOn-time71%
LufthansaCheapest$745Average$1,379FlexibilityNo cancel feeOn-time76%

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