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$324+ Cheap flights from Panama City (PTY) to Indianapolis (IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — IND
Mar 15 — Mar 221
Sun 3/15
Sun 3/22
1 adult, Economy
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Cheap flight deals from Panama City to Indianapolis

Cheapest flights from Panama City to Indianapolis
Explore the most affordable flight options available from Panama City to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.

This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/161:49 pm
PTY
-
IND
1 stop9h 10m
American Airlines
Thu 5/217:27 pm
IND
-
PTY
1 stop17h 47m
American Airlines
Deal found 2/10$432
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/141:49 pm
PTY
-
IND
1 stop20h 37m
American Airlines
Mon 5/186:36 pm
IND
-
PTY
2 stops19h 10m
American Airlines
Deal found 2/11$446
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/11:49 pm
PTY
-
IND
2 stops20h 57m
American Airlines
Fri 5/88:08 pm
IND
-
PTY
2 stops17h 38m
American Airlines
Deal found 2/10$465
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/11:49 pm
PTY
-
IND
2 stops22h 21m
American Airlines
Sun 5/105:34 pm
IND
-
PTY
2 stops20h 12m
American Airlines
Deal found 2/10$475
This Delta deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/33:15 pm
PTY
-
IND
1 stop8h 50m
Delta
Wed 3/186:00 am
IND
-
PTY
1 stop8h 03m
Delta
Deal found 2/13$487
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/172:40 pm
PTY
-
IND
2 stops22h 45m
American Airlines
Tue 3/35:38 pm
IND
-
PTY
2 stops20h 02m
American Airlines
Deal found 2/11$490
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/111:40 pm
PTY
-
IND
1 stop9h 19m
American Airlines
Sat 4/255:42 pm
IND
-
PTY
2 stops20h 04m
American Airlines
Deal found 2/9$492
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/191:49 pm
PTY
-
IND
1 stop9h 10m
American Airlines
Mon 6/17:27 pm
IND
-
PTY
1 stop17h 47m
American Airlines
Deal found 2/12$511

Find flight deals from Panama City to Indianapolis

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Indianapolis (IND). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$432
(American Airlines)

One-way from

$324
(United Airlines)

Popular in

August

Cheapest in

March

Average price

$644
Provider with most accurate pricing for Panama City Tocumen Intl-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Indianapolis flights.
Search Deals
From Panama City Tocumen Intl to Indianapolis
Search Deals
One-way flight from Panama City Tocumen Intl to Indianapolis
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($85 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from Panama City to Indianapolis that are best for you.

Fly from

Panama City

Fly to

Indianapolis

Route

Depart

Return

Price

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Thu 4/16

1:49 pm-11:59 pm

1 stop9h 10m

Indianapolis

Thu 5/21

7:27 pm-12:14 pm

1 stop17h 47m

$432

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Thu 5/14

1:49 pm-11:26 am

1 stop20h 37m

Indianapolis

Mon 5/18

6:36 pm-12:46 pm

2 stops19h 10m

$446

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Fri 5/1

1:49 pm-11:46 am

2 stops20h 57m

Indianapolis

Fri 5/8

8:08 pm-12:46 pm

2 stops17h 38m

$465

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Fri 5/1

1:49 pm-11:26 am

1 stop20h 37m

Indianapolis

Sun 5/10

5:31 pm-12:46 pm

2 stops20h 15m

$475

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Thu 4/30

1:49 pm-1:10 pm

2 stops22h 21m

Indianapolis

Sun 5/10

8:08 pm-12:46 pm

2 stops17h 38m

$475

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Tue 3/3

3:15 pm-12:05 am

1 stop8h 50m

Indianapolis

Wed 3/18

6:00 am-1:03 pm

1 stop8h 03m

$487

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Tue 5/19

1:49 pm-11:59 pm

1 stop9h 10m

Indianapolis

Mon 6/1

7:27 pm-12:14 pm

1 stop17h 47m

$511

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Thu 5/28

1:14 pm-11:59 pm

1 stop9h 45m

Indianapolis

Thu 6/4

7:27 pm-12:14 pm

1 stop17h 47m

$520

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Tue 6/9

3:30 pm-10:54 am

1 stop18h 24m

$324

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Mon 6/8

7:55 am-11:25 pm

1 stop14h 30m

$324

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/11

Showing 1-10 of 15 results
1
2

Compare providers for flights from Panama City to Indianapolis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Indianapolis in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Indianapolis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Indianapolis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Indianapolis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Indianapolis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Indianapolis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Indianapolis

What is the cheapest month to book a flight from Panama City to Indianapolis?

Currently, June is the cheapest month in which you can book a flight from Panama City to Indianapolis (average of $254). Flying from Panama City to Indianapolis in July is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Panama City to Indianapolis?

Reviews of airlines servicing Indianapolis

Get insights into the airlines that provide service to Indianapolis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indianapolis. Reviews last updated February 13, 2026.
See what other customers who have flown with Delta and United Airlines from Panama City to Indianapolis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,191 reviews

Entertainment

7.8

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,191 reviews
Delta
7.9
Good
8,191 reviews

Entertainment

7.8

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,286 reviews
Delta
7.9
Good
8,191 reviews

Entertainment

7.8

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Indianapolis?

    There are many flights that can get you from Panama City to Indianapolis in 9h 10m. Fly via American Airlines to get the fastest option. The distance between Panama City and Indianapolis is about 2158 mi.

  • What are the cheapest airlines flying from Panama City to Indianapolis round-trip?

    Currently priced at $311, Delta will fly you from Panama City to Indianapolis and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on United Airlines for as low as $458. Delta is currently priced 49% below the average price you’ll pay for this route.

  • Can I find deals for flights from Panama City to Indianapolis that include hotel bookings?

    Yes. In addition to deals on Panama City to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Indianapolis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Indianapolis.

  • Can I find deals for business class flights from Panama City to Indianapolis?

    Yes. Cheapflights offers flight deals from Panama City to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Indianapolis?

    Currently, June is the cheapest month in which you can book a flight from Panama City to Indianapolis (average of $254). Flying from Panama City to Indianapolis in July is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Muncie
Terre Haute
Fishers
Noblesville
Greenwood
Plainfield
Anderson
Kokomo
Mooresville
Franklin
Carmel
Crawfordsville
Bloomington

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to Indianapolis

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to O'Hare Intl flights
Panama City to Louisville flights
Panama City to Cincinnati flights

Top 2 airlines flying from Panama City to Indianapolis

Discover the top 2 airlines that operate flights from Panama City to Indianapolis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$311Average$568FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$458Average$665FlexibilityNo cancel feeOn-time69%

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