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$325+ Cheap flights from Panama City (PTY) to Indianapolis (IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/13. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — IND
Mar 24 — Mar 311
Tue 3/24
Tue 3/31
1 adult, Economy
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Cheap flight deals from Panama City to Indianapolis

Cheapest flights from Panama City to Indianapolis
Explore the most affordable flight options available from Panama City to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 22, 2026.

This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/113:40 pm
PTY
-
IND
2 stops20h 45m
American Airlines
Mon 9/148:08 pm
IND
-
PTY
2 stops19h 02m
American Airlines
Deal found 2/21$436
This American Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/161:49 pm
PTY
-
IND
1 stop9h 10m
American Airlines
Thu 5/214:35 pm
IND
-
PTY
2 stops20h 39m
American Airlines
Deal found 2/22$454
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:21 pm
PTY
-
IND
1 stop9h 13m
Delta
Mon 9/146:00 am
IND
-
PTY
1 stop7h 56m
Delta
Deal found 2/21$462
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/143:40 pm
PTY
-
IND
1 stop29h 44m
American Airlines
Thu 9/177:09 pm
IND
-
PTY
1 stop20h 01m
American Airlines
Deal found 2/21$471
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/71:49 pm
PTY
-
IND
2 stops22h 21m
American Airlines
Tue 4/147:43 pm
IND
-
PTY
2 stops18h 03m
American Airlines
Deal found 2/21$501
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/281:14 pm
PTY
-
IND
1 stop28h 18m
American Airlines
Thu 6/47:27 pm
IND
-
PTY
1 stop17h 47m
American Airlines
Deal found 2/20$525

Find flight deals from Panama City to Indianapolis

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Indianapolis (IND). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$454
(American Airlines)

One-way from

$325
(Mytrip)

Popular in

August

Cheapest in

March

Average price

$644
Provider with most accurate pricing for Panama City Tocumen Intl-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Indianapolis flights.
Search Deals
From Panama City Tocumen Intl to Indianapolis
Search Deals
One-way flight from Panama City Tocumen Intl to Indianapolis
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($85 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2026.
Use the filters below to find and compare flights from Panama City to Indianapolis that are best for you.

Fly from

Panama City

Fly to

Indianapolis

Route

Depart

Return

Price

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Thu 4/16

1:49 pm-11:59 pm

1 stop9h 10m

Indianapolis

Thu 5/21

7:27 pm-12:14 pm

1 stop17h 47m

$476

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Thu 5/28

1:14 pm-6:32 pm

1 stop28h 18m

Indianapolis

Thu 6/4

7:27 pm-12:14 pm

1 stop17h 47m

$525

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Tue 7/7

10:00 am-11:40 pm

2 stops12h 40m

Indianapolis

Tue 7/14

3:19 pm-4:04 am

2 stops13h 45m

$559

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Tue 5/5

9:45 am-8:22 pm

1 stop9h 37m

Indianapolis

Sun 5/10

9:10 pm-2:14 pm

2 stops18h 04m

$575

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Sat 5/23

1:14 pm-6:32 pm

1 stop28h 18m

Indianapolis

Sat 6/6

6:00 am-12:14 pm

1 stop7h 14m

$584

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Sat 5/23

1:14 pm-6:32 pm

1 stop28h 18m

Indianapolis

Sat 5/30

7:27 pm-12:14 pm

1 stop17h 47m

$584

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Fri 3/13

5:50 pm-11:15 pm

3 stops28h 25m

$325

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Tue 6/9

10:00 am-11:26 pm

1 stop12h 26m

$334

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Mon 6/8

10:00 am-11:26 pm

1 stop12h 26m

$334

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Thu 6/11

10:00 am-11:26 pm

1 stop12h 26m

$334

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/21

Showing 1-10 of 16 results
1
2

Compare providers for flights from Panama City to Indianapolis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Indianapolis in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Indianapolis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Indianapolis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Indianapolis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Indianapolis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Indianapolis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Indianapolis

What is the cheapest month to book a flight from Panama City to Indianapolis?

Currently, June is the cheapest month in which you can book a flight from Panama City to Indianapolis (average of $254). Flying from Panama City to Indianapolis in July is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Panama City to Indianapolis?

Reviews of airlines servicing Indianapolis

Get insights into the airlines that provide service to Indianapolis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indianapolis. Reviews last updated February 22, 2026.
See what other customers who have flown with Delta and United Airlines from Panama City to Indianapolis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,241 reviews

Food

7.2

Crew

8.5

Entertainment

7.8

Overall

7.9

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,241 reviews
Delta
7.9
Good
8,241 reviews

Food

7.2

Crew

8.5

Entertainment

7.8

Overall

7.9

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,341 reviews
Delta
7.9
Good
8,241 reviews

Food

7.2

Crew

8.5

Entertainment

7.8

Overall

7.9

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Indianapolis?

    There are many flights that can get you from Panama City to Indianapolis in 9h 10m. Fly via American Airlines to get the fastest option. The distance between Panama City and Indianapolis is about 2158 mi.

  • What are the cheapest airlines flying from Panama City to Indianapolis round-trip?

    Currently priced at $311, Delta will fly you from Panama City to Indianapolis and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on United Airlines for as low as $458. Delta is currently priced 49% below the average price you’ll pay for this route.

  • Can I find deals for flights from Panama City to Indianapolis that include hotel bookings?

    Yes. In addition to deals on Panama City to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Indianapolis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Indianapolis.

  • Can I find deals for business class flights from Panama City to Indianapolis?

    Yes. Cheapflights offers flight deals from Panama City to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Indianapolis?

    Currently, June is the cheapest month in which you can book a flight from Panama City to Indianapolis (average of $254). Flying from Panama City to Indianapolis in July is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Muncie
Terre Haute
Fishers
Noblesville
Greenwood
Plainfield
Kokomo
Mooresville
Franklin
Anderson
Carmel
Crawfordsville
Bloomington

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to Indianapolis

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to O'Hare Intl flights
Panama City to Louisville flights
Panama City to Cincinnati flights

Top 2 airlines flying from Panama City to Indianapolis

Discover the top 2 airlines that operate flights from Panama City to Indianapolis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$311Average$568FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$458Average$665FlexibilityNo cancel feeOn-time69%

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