What are the cheapest airlines flying from Panama City to Indianapolis round-trip?

Currently priced at $312, Delta will fly you from Panama City to Indianapolis and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from United Airlines and American Airlines - these airlines can fly you to your destination from $481 and $496, respectively. Delta is currently priced 47% below the average price you’ll pay for this route.

What is the cheapest day to fly from Panama City to Indianapolis?

Travelers seeking maximum savings on their Panama City to Indianapolis flight should consider departing on Friday afternoons when fares are most often at their lowest. Wednesday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Indianapolis ranges from 2.3 - 5.1 inches per month. May is typically the wettest month, when rainfall can reach 5.1 in. February is typically the driest time to visit Indianapolis when rainfall is around 2.3 in.

If weather is an important factor for your trip to Indianapolis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 75.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

What are the most popular airlines that fly from Panama City to Indianapolis?

American Airlines, Delta and United Airlines are the most popular airlines when flying from Panama City to Indianapolis.

What is the cheapest day to fly round-trip from Panama City to Indianapolis?

Thursday is generally a great day to depart. Flying on this day could help you save up to 21%.

What is the cheapest month to fly from Panama City to Indianapolis?

Flights from Panama City to Indianapolis lean towards being more expensive in August. Prices are generally better when you fly from Panama City to Indianapolis in December, with the cheapest ticket starting at $312.

Can I find deals for flights from Panama City to Indianapolis that include hotel bookings?

Yes. In addition to deals on Panama City to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to Indianapolis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Indianapolis.

Can I find deals for business class flights from Panama City to Indianapolis?

Yes. Cheapflights offers flight deals from Panama City to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$303+ Cheap Flights from Panama City to Indianapolis

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Cheap flight deals from Panama City to Indianapolis

Round-trip from	$505 (Delta)
One-way from	$303 (Kiwi.com)
Popular in	August
Cheapest in	December
Average price	$654

From Panama City Tocumen Intl to Indianapolis

Search Deals

One-way flight from Panama City Tocumen Intl to Indianapolis

Search Deals

Highest demand for flights based on searches. 3% potential increase in price ($22 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in August 2025

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Find flight deals from Panama City to Indianapolis

Cheapest flights from Panama City to Indianapolis
Explore the most affordable flight options available from Panama City to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Thu 10/92:21 pmPTY - IND

1 stop9h 01mDelta

Mon 10/136:00 amIND - PTY

1 stop7h 56mDelta

Deal found 8/12

$505

Thu 10/93:15 pmPTY - IND

1 stop8h 20mAmerican Airlines

Tue 10/146:30 amIND - PTY

1 stop8h 33mAmerican Airlines

Deal found 8/12

$514

Thu 10/93:15 pmPTY - IND

1 stop8h 20mAmerican Airlines

Mon 10/136:56 pmIND - PTY

2 stops20h 07mAmerican Airlines

Deal found 8/12

$518

Thu 10/910:00 amPTY - IND

1 stop12h 30mUnited Airlines

Sun 10/266:00 amIND - PTY

2 stops13h 38mUnited Airlines

Deal found 8/12

$526

Wed 10/83:15 pmPTY - IND

2 stops20h 04mAmerican Airlines

Sun 10/126:56 pmIND - PTY

2 stops20h 07mAmerican Airlines

Deal found 8/13

$540

Tue 12/3011:55 pmPTY - IND

2 stops15h 27mUnited Airlines

Fri 1/910:00 amIND - PTY

1 stop10h 02mUnited Airlines

Deal found 8/12

$566

Wed 8/203:30 pmPTY - IND

1 stop18h 32mUnited Airlines

Wed 10/157:00 amIND - PTY

1 stop8h 14mUnited Airlines

Deal found 8/13

$570

Fri 9/123:31 pmPTY - IND

2 stops20h 05mAmerican Airlines

Fri 9/196:55 pmIND - PTY

1 stop20h 36mAmerican Airlines

Deal found 8/13

$582

Thu 9/113:20 amPTY - IND

2 stops18h 51mMultiple Airlines

Fri 9/1911:10 amIND - PTY

2 stops14h 35mMultiple Airlines

Deal found 8/13

$588

Fri 9/123:30 pmPTY - IND

2 stops20h 47mUnited Airlines

Fri 9/199:10 amIND - PTY

1 stop10h 27mUnited Airlines

Deal found 8/13

$590

Best flights from Panama City to Indianapolis
Discover carefully curated flight deals from Panama City to Indianapolis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2025.

Tue 11/43:21 pmPTY - IND

1 stop9h 01mDelta

Tue 11/117:10 amIND - PTY

1 stop6h 42mDelta

Deal found 8/13

$505

Thu 10/910:00 amPTY - IND

1 stop12h 30mUnited Airlines

Mon 10/135:24 pmIND - PTY

1 stop26h 13mUnited Airlines

Deal found 8/11

$505

Thu 10/93:15 pmPTY - IND

1 stop8h 20mAmerican Airlines

Tue 10/146:30 amIND - PTY

1 stop8h 33mAmerican Airlines

Deal found 8/12

$514

Wed 1/213:27 pmPTY - IND

1 stop8h 30mDelta

Tue 1/276:00 amIND - PTY

1 stop8h 02mDelta

Deal found 8/13

$505

Wed 1/214:40 pmPTY - IND

2 stops20h 17mUnited Airlines

Tue 1/279:00 amIND - PTY

2 stops10h 38mUnited Airlines

Deal found 8/13

$505

Tue 11/42:43 pmPTY - IND

2 stops20h 00mAmerican Airlines

Tue 11/119:27 pmIND - PTY

2 stops16h 09mAmerican Airlines

Deal found 8/13

$518

Thu 10/92:21 pmPTY - IND

1 stop9h 01mDelta

Mon 10/136:00 amIND - PTY

1 stop7h 56mDelta

Deal found 8/12

$505

Thu 10/910:00 amPTY - IND

1 stop12h 30mUnited Airlines

Sun 10/269:00 amIND - PTY

1 stop29h 45mUnited Airlines

Deal found 8/12

$505

Thu 10/910:00 amPTY - IND

1 stop12h 30mUnited Airlines

Tue 10/146:00 amIND - PTY

2 stops13h 37mUnited Airlines

Deal found 8/12

$505

Thu 10/92:21 pmPTY - IND

1 stop7h 48mDelta

Tue 10/147:00 amIND - PTY

1 stop6h 56mDelta

Deal found 8/12

$505

Last-minute flights from Panama City to Indianapolis
Discover last-minute flight deals from Panama City to Indianapolis. Data last updated August 14, 2025 and is based on user searches.

Wed 8/203:30 pmPTY - IND

1 stop18h 32mUnited Airlines

Wed 10/157:00 amIND - PTY

1 stop8h 14mUnited Airlines

Deal found 8/13

$570

Wed 8/203:30 pmPTY - IND

2 stops19h 25mAmerican Airlines

Wed 10/156:00 amIND - PTY

2 stops9h 03mAmerican Airlines

Deal found 8/13

$596

Wed 8/205:25 pmPTY - IND

3 stops27h 51mMultiple Airlines

Wed 10/155:15 amIND - PTY

3 stops20h 30mMultiple Airlines

Deal found 8/13

$677

Wed 8/203:30 pmPTY - IND

2 stops18h 39mUnited Airlines

Wed 10/155:24 pmIND - PTY

1 stop26h 13mUnited Airlines

Deal found 8/13

$570

Fri 8/293:30 pmPTY - IND

1 stop7h 46mAmerican Airlines

Sun 9/76:19 amIND - PTY

1 stop9h 12mAmerican Airlines

Deal found 8/12

$621

Thu 9/113:20 amPTY - IND

2 stops18h 51mMultiple Airlines

Fri 9/1911:10 amIND - PTY

2 stops14h 35mMultiple Airlines

Deal found 8/13

$588

Fri 9/123:31 pmPTY - IND

2 stops20h 05mAmerican Airlines

Fri 9/196:55 pmIND - PTY

1 stop20h 36mAmerican Airlines

Deal found 8/13

$582

Fri 9/122:10 pmPTY - IND

1 stop8h 55mDelta

Fri 9/197:05 amIND - PTY

1 stop6h 50mDelta

Deal found 8/13

$590

One-way flights from Panama City to Indianapolis
Search for one-way flight options from Panama City to Indianapolis. Find affordable one-way fares based on user searches. Data last updated August 14, 2025.

Mon 9/2910:05 pmPTY - IND

2 stops20h 42mMultiple Airlines

Deal found 8/13

$303

Thu 10/910:00 amPTY - IND

1 stop12h 30mUnited Airlines

Deal found 8/11

$307

Fri 10/313:15 pmPTY - IND

1 stop26h 02mAmerican Airlines

Deal found 8/13

$311

Thu 10/93:15 pmPTY - IND

2 stops20h 55mAmerican Airlines

Deal found 8/11

$316

Thu 10/302:55 amPTY - IND

2 stops19h 16mMultiple Airlines

Deal found 8/13

$325

Sun 10/123:20 amPTY - IND

2 stops18h 51mMultiple Airlines

Deal found 8/13

$326

Thu 10/95:25 pmPTY - IND

3 stops26h 49mMultiple Airlines

Deal found 8/12

$338

Sun 9/710:00 amPTY - IND

1 stop12h 27mUnited Airlines

Deal found 8/14

$354

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Tue 11/4

3:21 pm-12:22 am

1 stop9h 01m

Indianapolis

Tue 11/11

7:10 am-1:52 pm

1 stop6h 42m

$505

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Thu 10/9

10:00 am-11:30 pm

1 stop12h 30m

Indianapolis

Mon 10/13

5:24 pm-6:37 pm

1 stop26h 13m

$505

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Wed 1/21

3:27 pm-11:57 pm

1 stop8h 30m

Indianapolis

Tue 1/27

6:00 am-2:02 pm

1 stop8h 02m

$505

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Wed 1/21

4:40 pm-12:57 pm

2 stops20h 17m

Indianapolis

Tue 1/27

9:00 am-7:38 pm

2 stops10h 38m

$505

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Thu 10/9

2:21 pm-12:22 am

1 stop9h 01m

Indianapolis

Mon 10/13

6:00 am-12:56 pm

1 stop7h 56m

$505

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Thu 10/9

10:00 am-11:30 pm

1 stop12h 30m

Indianapolis

Sun 10/26

9:00 am-1:45 pm

1 stop29h 45m

$505

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Thu 10/9

10:00 am-11:30 pm

1 stop12h 30m

Indianapolis

Tue 10/14

6:00 am-6:37 pm

2 stops13h 37m

$505

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Thu 10/9

2:21 pm-11:09 pm

1 stop7h 48m

Indianapolis

Tue 10/14

7:00 am-12:56 pm

1 stop6h 56m

$505

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Thu 10/9

3:15 pm-12:35 am

1 stop8h 20m

Indianapolis

Tue 10/14

6:30 am-2:03 pm

1 stop8h 33m

$514

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Tue 11/4

2:43 pm-10:43 am

2 stops20h 00m

Indianapolis

Tue 11/11

9:27 pm-1:36 pm

2 stops16h 09m

$518

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Showing 1-10 of 16 results

Best time to book a flight from Panama City to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Indianapolis

What is the cheapest month to book a flight from Panama City to Indianapolis?

Currently, August is the cheapest month in which you can book a flight from Panama City to Indianapolis (average of $297). Flying from Panama City to Indianapolis in March is currently the most expensive (average of $361). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to IND?

A simple way to save on the total cost of your ticket is to fly from Panama City to Indianapolis at noon. If you’re flexible enough to do this you can expect to save up to 18% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing Indianapolis

See what other customers who have flown with Delta, United Airlines, and American Airlines from Panama City to Indianapolis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

6.0

Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others

Delta

8.0

Very good

7,980 reviews

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

6.0

Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others

United Airlines

7.4

Good

8,916 reviews

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

6.0

Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

6.0

Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others

Related info for your journey

What are the cheapest airlines flying from Panama City to Indianapolis round-trip?
Currently priced at $312, Delta will fly you from Panama City to Indianapolis and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from United Airlines and American Airlines - these airlines can fly you to your destination from $481 and $496, respectively. Delta is currently priced 47% below the average price you’ll pay for this route.
Can I find deals for flights from Panama City to Indianapolis that include hotel bookings?
Yes. In addition to deals on Panama City to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Indianapolis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Indianapolis.
Can I find deals for business class flights from Panama City to Indianapolis?
Yes. Cheapflights offers flight deals from Panama City to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Indianapolis?
Currently, August is the cheapest month in which you can book a flight from Panama City to Indianapolis (average of $297). Flying from Panama City to Indianapolis in March is currently the most expensive (average of $361). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Greenwood

Bloomington

Muncie

Noblesville

Fishers

Terre Haute

Anderson

Kokomo

Franklin

Plainfield

Carmel

Crawfordsville

Shelbyville

Speedway

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Panama City to Indianapolis

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$312	Average$516	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$481	Average$642	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$496	Average$644	FlexibilityNo cancel fee	On-time71%

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$303+ Cheap flights from Panama City (PTY) to Indianapolis (IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Indianapolis with Cheapflights

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2. Select your favorite providers

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Cheap flight deals from Panama City to Indianapolis

Round-trip from

One-way from

Popular in

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Average price

Find flight deals from Panama City to Indianapolis

Cheapest flights from Panama City to IndianapolisExplore the most affordable flight options available from Panama City to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Explore the most affordable flight options available from Panama City to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Indianapolis that are best for you.

Best time to book a flight from Panama City to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Indianapolis

What is the cheapest month to book a flight from Panama City to Indianapolis?

What is the cheapest time of day to fly from PTY to IND?

Find hourly flight availability from Panama City to Indianapolis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

Reviews of airlines servicing Indianapolis

See what other customers who have flown with Delta, United Airlines, and American Airlines from Panama City to Indianapolis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Panama City to Indianapolis round-trip?

Can I find deals for flights from Panama City to Indianapolis that include hotel bookings?

How can I find direct flights from Panama City to Indianapolis?

Can I find deals for business class flights from Panama City to Indianapolis?

What is the cheapest month to book a flight from Panama City to Indianapolis?

Traveling to a place near Indianapolis?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Indianapolis

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Panama City to Indianapolis

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Cheapest flights from Panama City to Indianapolis
Explore the most affordable flight options available from Panama City to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.