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$651+ Cheap flights from Des Moines (DSM) to Guayaquil (GYE)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GYE
out 11 — out 181
sáb 10/11
sáb 10/18
1 adult, Economy
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Cheap flight deals from Des Moines to Guayaquil

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated setembro 11, 2025.

Round-trip from

$651
(American Airlines)
From Des Moines to Guayaquil Jose Joaquin de Olmedo
Search Deals

Find flight deals from Des Moines to Guayaquil

Cheapest flights from Des Moines to Guayaquil
Explore the most affordable flight options available from Des Moines to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on setembro 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb 10/116:22 pmDSM - GYE
2 stops24h 48mAmerican Airlines
sex 11/216:00 amGYE - DSM
2 stops27h 21mAmerican Airlines
Deal found 9/11$651
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 12/256:00 amDSM - GYE
1 stop16h 49mAmerican Airlines
sáb 1/36:04 amGYE - DSM
2 stops29h 43mAmerican Airlines
Deal found 9/11$1,725
This Priceline deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 12/258:00 amDSM - GYE
2 stops32h 45mAvianca
sex 1/24:40 amGYE - DSM
2 stops42h 00mAvianca
Deal found 9/11$3,798

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated setembro 11, 2025.
Use the filters below to find and compare flights from Des Moines to Guayaquil that are best for you.

Fly from

Des Moines

Fly to

Guayaquil

Route

Depart

Return

Price

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

sáb 10/11

6:00 am-7:10 pm

2 stops13h 10m

Guayaquil Jose Joaquin de Olmedo

sex 11/21

6:00 am-11:33 pm

1 stop18h 33m

$932

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

qui 12/25

5:07 am-11:49 pm

2 stops17h 42m

Guayaquil Jose Joaquin de Olmedo

sáb 1/3

6:04 am-10:47 am

2 stops29h 43m

$1,725

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

qui 12/25

8:00 am-5:45 pm

2 stops32h 45m

Guayaquil Jose Joaquin de Olmedo

sex 1/2

4:40 am-9:40 pm

2 stops42h 00m

$3,798

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Best time to book a flight from Des Moines to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Guayaquil

Get insights into the airlines that provide service to Guayaquil. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guayaquil. Reviews last updated setembro 11, 2025.
Get a feel of what it's like to fly with American Airlines from Des Moines to Guayaquil by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Crew

8.0

Food

6.4

Overall

7.2

Boarding

7.5

Comfort

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Crew

8.0

Food

6.4

Overall

7.2

Boarding

7.5

Comfort

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Guayaquil?

    Departing from Des Moines to Guayaquil will take you 13h 10m. The distance from Des Moines to Guayaquil is about 3138 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Des Moines to Guayaquil round-trip?

    According to our current data, American Airlines ($609), offers the cheapest pricing from Des Moines to Guayaquil.

  • Can I find deals for flights from Des Moines to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Des Moines to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Guayaquil.

  • Can I find deals for business class flights from Des Moines to Guayaquil?

    Yes. Cheapflights offers flight deals from Des Moines to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Guayaquil?

    Currently, April is the cheapest month in which you can book a flight from Des Moines to Guayaquil (average of $440). Flying from Des Moines to Guayaquil in December is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Des Moines to Guayaquil

Discover the top airline that operate flights from Des Moines to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated setembro 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$609Average$967FlexibilityNo cancel feeOn-time71%

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