$473+ Cheap flights from Des Moines (DSM) to Guayaquil (GYE)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GYE
Nov 27 — Dec 41
1 adult, Economy
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Cheapest flights from Des Moines to GuayaquilExplore the most affordable flight options available from Des Moines to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.
Explore the most affordable flight options available from Des Moines to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:56 pmDSM - GYE
1 stop31h 47mMultiple Airlines
Wed 12/1712:49 amGYE - DSM
1 stop22h 47mMultiple Airlines
Deal found 10/27![Multiple Airlines logo]()
$473
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:28 pmDSM - GYE
3 stops27h 15mMultiple Airlines
Thu 12/1812:49 amGYE - DSM
3 stops21h 24mMultiple Airlines
Deal found 10/28![Multiple Airlines logo]()
$642
Cheap flight deals from Des Moines to Guayaquil
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $473 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Des Moines to Guayaquil that are best for you.
Fly from
Des Moines
Fly to
Guayaquil
Route
Depart
Return
Price
Des MoinesGuayaquil
DSM - GYE
DSMGYE
Des Moines
Thu 12/11
2:56 pm-11:43 pm
1 stop31h 47m
Guayaquil Jose Joaquin de Olmedo
Wed 12/17
12:49 am-10:36 pm
1 stop22h 47m
$473
Des MoinesGuayaquil
DSM - GYE
DSMGYE
Des Moines
Tue 1/13
7:39 am-11:22 pm
2 stops14h 43m
Guayaquil Jose Joaquin de Olmedo
Tue 3/17
2:33 pm-4:17 pm
2 stops25h 44m
$621
Des MoinesGuayaquil
DSM - GYE
DSMGYE
Des Moines
Fri 12/12
7:28 pm-11:43 pm
3 stops27h 15m
Guayaquil Jose Joaquin de Olmedo
Thu 12/18
12:49 am-9:13 pm
3 stops21h 24m
$642
Compare providers for flights from Des Moines to Guayaquil
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Guayaquil in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*1 star | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Guayaquil flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Guayaquil flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Guayaquil flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Guayaquil flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Guayaquil flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Guayaquil
Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.