HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Greenville

$197+ Cheap flights from Santa Ana, CA to Greenville (SNA - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/11. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — GSP
Feb 19 — Feb 261
Thu 2/19
Thu 2/26
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Santa Ana to Greenville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Santa Ana to Greenville

Cheapest flights from Santa Ana to Greenville
Explore the most affordable flight options available from Santa Ana to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.

This United Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2410:51 am
SNA
-
GSP
1 stop6h 50m
United Airlines
Tue 3/1012:07 pm
GSP
-
SNA
1 stop10h 47m
United Airlines
Deal found 1/18$385
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/49:45 pm
SNA
-
GSP
1 stop8h 17m
Delta
Wed 5/135:45 am
GSP
-
SNA
1 stop8h 10m
Delta
Deal found 1/19$393
This Southwest deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:45 am
SNA
-
GSP
2 stops7h 55m
Southwest
Tue 3/106:20 am
GSP
-
SNA
2 stops10h 15m
Southwest
Deal found 1/18$396
This Southwest deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/77:05 am
SNA
-
GSP
2 stops7h 20m
Southwest
Thu 3/121:55 pm
GSP
-
SNA
2 stops11h 00m
Southwest
Deal found 1/19$404
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/19:45 pm
SNA
-
GSP
1 stop8h 17m
Delta
Wed 5/136:45 am
GSP
-
SNA
1 stop7h 10m
Delta
Deal found 1/19$420
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:45 am
SNA
-
GSP
1 stop6h 56m
Delta
Sat 5/95:45 am
GSP
-
SNA
1 stop8h 10m
Delta
Deal found 1/19$436
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/59:54 am
SNA
-
GSP
2 stops11h 02m
Delta
Wed 5/136:45 am
GSP
-
SNA
1 stop7h 10m
Delta
Deal found 1/19$441
This American Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/2611:41 am
SNA
-
GSP
1 stop9h 01m
American Airlines
Wed 4/17:40 am
GSP
-
SNA
1 stop9h 43m
American Airlines
Deal found 1/18$446
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:58 pm
SNA
-
GSP
2 stops11h 04m
Delta
Sat 5/911:10 am
GSP
-
SNA
2 stops12h 23m
Delta
Deal found 1/19$447

Find flight deals from Santa Ana to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$385
(United Airlines)

One-way from

$197
(American Airlines)

Popular in

December

Cheapest in

July

Average price

$491
Provider with most accurate pricing for Santa Ana J. Wayne/Orange Cnty-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santa Ana J. Wayne/Orange Cnty-Greenville flights.
Search Deals
From Santa Ana J. Wayne/Orange Cnty to Greenville
Search Deals
One-way flight from Santa Ana J. Wayne/Orange Cnty to Greenville
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($53 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Ana to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
Use the filters below to find and compare flights from Santa Ana to Greenville that are best for you.

Fly from

Santa Ana

Fly to

Greenville

Route

Depart

Return

Price

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 2/24

10:51 am-8:41 pm

1 stop6h 50m

Greenville

Tue 3/10

12:07 pm-7:54 pm

1 stop10h 47m

$385

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 3/7

11:41 am-10:14 pm

1 stop7h 33m

Greenville

Thu 3/12

7:40 am-2:23 pm

1 stop9h 43m

$393

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 2/24

6:45 am-5:40 pm

2 stops7h 55m

Greenville

Tue 3/10

6:20 am-1:35 pm

2 stops10h 15m

$396

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 3/7

7:05 am-5:25 pm

2 stops7h 20m

Greenville

Thu 3/12

1:55 pm-9:55 pm

2 stops11h 00m

$404

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Mon 5/4

9:45 pm-9:02 am

1 stop8h 17m

Greenville

Fri 5/15

3:42 pm-10:18 pm

1 stop9h 36m

$420

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 5/5

1:05 pm-10:46 pm

1 stop6h 41m

Greenville

Fri 5/15

3:42 pm-10:18 pm

1 stop9h 36m

$420

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Fri 5/1

9:45 pm-9:02 am

1 stop8h 17m

Greenville

Sat 5/9

6:45 am-10:55 am

1 stop7h 10m

$420

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 3/19

11:41 am-11:42 pm

1 stop9h 01m

Greenville

Mon 3/23

4:26 pm-10:45 pm

1 stop9h 19m

$436

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 5/2

6:45 am-4:41 pm

1 stop6h 56m

Greenville

Sat 5/9

5:45 am-10:55 am

1 stop8h 10m

$436

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 4/11

6:45 am-8:40 pm

2 stops10h 55m

$202

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/19

Showing 1-10 of 20 results
1
2

Compare providers for flights from Santa Ana to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Greenville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santa Ana, California-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Ana, California-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Ana, California-Greenville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Ana to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Santa Ana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Greenville

What is the cheapest month to book a flight from Santa Ana, California to Greenville?

Currently, May is the cheapest month in which you can book a flight from Santa Ana, California to Greenville (average of $116). Flying from Santa Ana, California to Greenville in January is currently the most expensive (average of $247). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated January 20, 2026.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Santa Ana to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,077 reviews

Food

7.2

Crew

8.5

Entertainment

7.8

Overall

7.9

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Delta
7.9
Good
8,077 reviews
Delta
7.9
Good
8,077 reviews

Food

7.2

Crew

8.5

Entertainment

7.8

Overall

7.9

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
United Airlines
7.4
Good
9,180 reviews
Delta
7.9
Good
8,077 reviews

Food

7.2

Crew

8.5

Entertainment

7.8

Overall

7.9

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
American Airlines
7.2
Good
11,164 reviews
Delta
7.9
Good
8,077 reviews

Food

7.2

Crew

8.5

Entertainment

7.8

Overall

7.9

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Ana, California to Greenville?

    A quick flight from Santa Ana, California to Greenville can take about 6h 50m. United Airlines provides one of the quickest options available for as low as $385. The distance from Santa Ana, California to Greenville is about 2025 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Santa Ana, California to Greenville round-trip?

    According to our current data, American Airlines ($324), Delta ($337), and United Airlines ($434) offers the cheapest pricing from Santa Ana, California to Greenville. American Airlines is priced at 35% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Santa Ana to Greenville that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Greenville.

  • Can I find deals for business class flights from Santa Ana to Greenville?

    Yes. Cheapflights offers flight deals from Santa Ana to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana, California to Greenville?

    Currently, May is the cheapest month in which you can book a flight from Santa Ana, California to Greenville (average of $116). Flying from Santa Ana, California to Greenville in January is currently the most expensive (average of $247). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santa Ana to Greenville

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to Charlotte flights
San Francisco to Charlotte flights
Los Angeles to Charleston flights
San Diego to Charlotte flights
San Francisco to Savannah flights
San Francisco to Charleston flights
Los Angeles to Savannah flights
Ontario to Charlotte flights
Las Vegas to Charlotte flights
Santa Ana to Charlotte flights
Ontario to Charleston flights
Los Angeles to Myrtle Beach flights
San Diego to Charleston flights
Los Angeles to Greenville flights
Los Angeles to Columbia flights
Ontario to Savannah flights
Sacramento to Charlotte flights
Sacramento to Charleston flights
Santa Ana to Charleston flights
San Francisco to Myrtle Beach flights
Burbank to Charlotte flights
Ontario to Columbia flights
San Jose to Charlotte flights
Oakland to Charlotte flights
San Jose to Savannah flights
San Diego to Savannah flights
Santa Ana to Savannah flights
San Jose to Charleston flights
San Diego to Myrtle Beach flights
Las Vegas to Charleston flights
Ontario to Myrtle Beach flights
Ontario to Greenville flights
Sacramento to Myrtle Beach flights
Reno to Charlotte flights
San Francisco to Greenville flights
Sacramento to Greenville flights
Reno to Charleston flights
Santa Barbara to Charlotte flights
Las Vegas to Myrtle Beach flights
Las Vegas to Savannah flights
Fresno to Charlotte flights
San Jose to Myrtle Beach flights
Oakland to Charleston flights
Burbank to Savannah flights
San Diego to Columbia flights
San Francisco to Columbia flights
Palm Springs to Charlotte flights
Burbank to Charleston flights
Sacramento to Savannah flights
Santa Ana to Augusta flights

Top 3 airlines flying from Santa Ana to Greenville

Discover the top 3 airlines that operate flights from Santa Ana to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$324Average$455FlexibilityNo cancel feeOn-time71%
DeltaCheapest$337Average$459FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$434Average$559FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.