$164+ Cheap flights from Santa Ana to Greenville (SNA - GSP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/21. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — GSP
Mar 30 — Apr 61
1 adult, Economy
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Find cheap flights from Santa Ana to Greenville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santa Ana to Greenville
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Best
Last-minute
One-way
Cheapest flights from Santa Ana to GreenvilleExplore the most affordable flight options available from Santa Ana to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 28, 2026.
Explore the most affordable flight options available from Santa Ana to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 28, 2026.
This Southwest deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:25 am
SNA
- GSP
2 stops11h 15m
Southwest
Mon 4/136:25 am
GSP
- SNA
2 stops8h 30m
Southwest
Deal found 2/26![Southwest logo]()
$422
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:45 am
SNA
- GSP
1 stop6h 36m
American Airlines
Mon 4/135:12 pm
GSP
- SNA
1 stop8h 33m
American Airlines
Deal found 2/25![American Airlines logo]()
$448
This Delta deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:15 pm
SNA
- GSP
2 stops12h 18m
Delta
Sat 10/1012:00 pm
GSP
- SNA
1 stop9h 38m
Delta
Deal found 2/27![Delta logo]()
$452
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2311:41 am
SNA
- GSP
1 stop9h 01m
American Airlines
Thu 3/266:01 am
GSP
- SNA
1 stop8h 56m
American Airlines
Deal found 2/25![American Airlines logo]()
$459
This Southwest deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/910:25 am
SNA
- GSP
2 stops8h 50m
Southwest
Sun 4/126:30 am
GSP
- SNA
2 stops8h 45m
Southwest
Deal found 2/26![Southwest logo]()
$474
This Southwest deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2011:40 am
SNA
- GSP
2 stops8h 05m
Southwest
Mon 3/231:55 pm
GSP
- SNA
2 stops11h 30m
Southwest
Deal found 2/25![Southwest logo]()
$490
This United Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:39 pm
SNA
- GSP
2 stops12h 16m
United Airlines
Mon 4/137:42 pm
GSP
- SNA
2 stops17h 02m
United Airlines
Deal found 2/25![United Airlines logo]()
$508
Best flights from Santa Ana to GreenvilleDiscover carefully curated flight deals from Santa Ana to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 28, 2026.
Discover carefully curated flight deals from Santa Ana to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 28, 2026.
This Southwest deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:25 am
SNA
- GSP
2 stops11h 15m
Southwest
Mon 4/136:25 am
GSP
- SNA
2 stops8h 30m
Southwest
Deal found 2/26![Southwest logo]()
$422
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:45 am
SNA
- GSP
1 stop6h 36m
American Airlines
Mon 4/135:12 pm
GSP
- SNA
1 stop8h 33m
American Airlines
Deal found 2/28![American Airlines logo]()
$457
This Delta deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2212:15 pm
SNA
- GSP
1 stop6h 45m
Delta
Sun 7/262:25 pm
GSP
- SNA
1 stop6h 55m
Delta
Deal found 2/25![Delta logo]()
$519
This United Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/256:26 pm
SNA
- GSP
2 stops12h 29m
United Airlines
Mon 6/294:15 pm
GSP
- SNA
1 stop8h 46m
United Airlines
Deal found 2/25![United Airlines logo]()
$552
This Southwest deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2011:40 am
SNA
- GSP
2 stops8h 05m
Southwest
Mon 3/231:55 pm
GSP
- SNA
2 stops11h 30m
Southwest
Deal found 2/25![Southwest logo]()
$490
This Delta deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/88:00 am
SNA
- GSP
2 stops11h 05m
Delta
Mon 4/135:23 pm
GSP
- SNA
1 stop7h 51m
Delta
Deal found 2/26![Delta logo]()
$524
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/2512:55 pm
SNA
- GSP
1 stop7h 02m
American Airlines
Mon 6/297:25 am
GSP
- SNA
1 stop9h 54m
American Airlines
Deal found 2/26![American Airlines logo]()
$555
Last-minute flights from Santa Ana to GreenvilleDiscover last-minute flight deals from Santa Ana to Greenville. Data last updated February 28, 2026 and is based on user searches.
Discover last-minute flight deals from Santa Ana to Greenville. Data last updated February 28, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/127:30 am
SNA
- GSP
2 stops13h 24m
Delta
Mon 3/165:41 pm
GSP
- SNA
1 stop7h 31m
Delta
Deal found 2/25![Delta logo]()
$572
This Southwest deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1210:10 am
SNA
- GSP
2 stops9h 35m
Southwest
Mon 3/161:55 pm
GSP
- SNA
2 stops11h 30m
Southwest
Deal found 2/25![Southwest logo]()
$577
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1211:41 am
SNA
- GSP
1 stop9h 01m
American Airlines
Mon 3/164:30 pm
GSP
- SNA
1 stop9h 15m
American Airlines
Deal found 2/25![American Airlines logo]()
$600
This Delta deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/1412:34 pm
SNA
- GSP
1 stop8h 20m
Delta
Wed 3/185:40 am
GSP
- SNA
1 stop8h 44m
Delta
Deal found 2/27![Delta logo]()
$567
This Southwest deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1910:10 am
SNA
- GSP
2 stops9h 35m
Southwest
Sun 3/2212:30 pm
GSP
- SNA
2 stops10h 50m
Southwest
Deal found 2/27![Southwest logo]()
$637
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/197:45 am
SNA
- GSP
1 stop9h 01m
American Airlines
Sun 3/226:01 am
GSP
- SNA
1 stop8h 56m
American Airlines
Deal found 2/27![American Airlines logo]()
$638
This Southwest deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2011:40 am
SNA
- GSP
2 stops8h 05m
Southwest
Mon 3/231:55 pm
GSP
- SNA
2 stops11h 30m
Southwest
Deal found 2/25![Southwest logo]()
$490
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/207:48 pm
SNA
- GSP
2 stops9h 50m
American Airlines
Mon 3/234:30 pm
GSP
- SNA
1 stop9h 15m
American Airlines
Deal found 2/25![American Airlines logo]()
$611
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2311:41 am
SNA
- GSP
1 stop9h 01m
American Airlines
Thu 3/266:01 am
GSP
- SNA
1 stop8h 56m
American Airlines
Deal found 2/25![American Airlines logo]()
$459
This Southwest deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2311:40 am
SNA
- GSP
2 stops8h 05m
Southwest
Thu 3/261:55 pm
GSP
- SNA
2 stops11h 30m
Southwest
Deal found 2/25![Southwest logo]()
$530
One-way flights from Santa Ana to GreenvilleSearch for one-way flight options from Santa Ana to Greenville. Find affordable one-way fares based on user searches. Data last updated February 28, 2026.
Search for one-way flight options from Santa Ana to Greenville. Find affordable one-way fares based on user searches. Data last updated February 28, 2026.
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/211:23 pm
SNA
- GSP
1 stop6h 17m
American Airlines
Deal found 2/27![American Airlines logo]()
$164
This United Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:44 pm
SNA
- GSP
2 stops11h 02m
United Airlines
Deal found 2/27![United Airlines logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:45 am
SNA
- GSP
3 stops51h 27m
Multiple Airlines
Deal found 2/27![Multiple Airlines logo]()
$212
This Delta deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/275:05 pm
SNA
- GSP
2 stops13h 22m
Delta
Deal found 2/27![Delta logo]()
$229
This Southwest deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/299:10 pm
SNA
- GSP
2 stops11h 35m
Southwest
Deal found 2/27![Southwest logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/297:53 pm
SNA
- GSP
3 stops20h 45m
Multiple Airlines
Deal found 2/26![Multiple Airlines logo]()
$244
This United Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:28 pm
SNA
- GSP
2 stops13h 46m
United Airlines
Deal found 2/28![United Airlines logo]()
$245
This Delta deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/287:45 am
SNA
- GSP
1 stop9h 32m
Delta
Deal found 2/27![Delta logo]()
$255
This United Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/259:14 pm
SNA
- GSP
1 stop10h 23m
United Airlines
Deal found 2/27![United Airlines logo]()
$274
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:45 am
SNA
- GSP
1 stop9h 01m
American Airlines
Deal found 2/28![American Airlines logo]()
$288
Find flight deals from Santa Ana to Greenville
Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $422 (Southwest) |
One-way from | $164 (American Airlines) |
Popular in | February |
Cheapest in | July |
Average price | $645 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santa Ana to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 28, 2026.
Use the filters below to find and compare flights from Santa Ana to Greenville that are best for you.
Fly from
Fly to
Route
Depart
Return
Santa AnaGreenville
SNA - GSP
SNAGSP
Santa Ana J. Wayne/Orange Cnty
Wed 4/8
7:25 am-9:40 pm
2 stops11h 15m
Greenville
Mon 4/13
6:25 am-11:55 am
2 stops8h 30m
$422
Santa AnaGreenville
SNA - GSP
SNAGSP
Santa Ana J. Wayne/Orange Cnty
Wed 4/8
6:45 am-4:21 pm
1 stop6h 36m
Greenville
Mon 4/13
5:12 pm-10:45 pm
1 stop8h 33m
$457
Santa AnaGreenville
SNA - GSP
SNAGSP
Santa Ana J. Wayne/Orange Cnty
Fri 3/20
11:40 am-10:45 pm
2 stops8h 05m
Greenville
Mon 3/23
1:55 pm-10:25 pm
2 stops11h 30m
$490
Santa AnaGreenville
SNA - GSP
SNAGSP
Santa Ana J. Wayne/Orange Cnty
Wed 7/22
12:15 pm-10:00 pm
1 stop6h 45m
Greenville
Sun 7/26
2:25 pm-6:20 pm
1 stop6h 55m
$519
Santa AnaGreenville
SNA - GSP
SNAGSP
Santa Ana J. Wayne/Orange Cnty
Wed 4/8
8:00 am-10:05 pm
2 stops11h 05m
Greenville
Mon 4/13
5:23 pm-10:14 pm
1 stop7h 51m
$524
Santa AnaGreenville
SNA - GSP
SNAGSP
Santa Ana J. Wayne/Orange Cnty
Thu 6/25
6:26 pm-9:55 am
2 stops12h 29m
Greenville
Mon 6/29
4:15 pm-10:01 pm
1 stop8h 46m
$552
Santa AnaGreenville
SNA - GSP
SNAGSP
Santa Ana J. Wayne/Orange Cnty
Thu 6/25
12:55 pm-10:57 pm
1 stop7h 02m
Greenville
Mon 6/29
7:25 am-2:19 pm
1 stop9h 54m
$555
Santa AnaGreenville
SNA - GSP
SNAGSP
Santa Ana J. Wayne/Orange Cnty
Tue 4/21
7:44 pm-9:46 am
2 stops11h 02m
$194
Santa AnaGreenville
SNA - GSP
SNAGSP
Santa Ana J. Wayne/Orange Cnty
Mon 7/27
5:05 pm-9:27 am
2 stops13h 22m
$229
Santa AnaGreenville
SNA - GSP
SNAGSP
Santa Ana J. Wayne/Orange Cnty
Sun 3/29
9:10 pm-11:45 am
2 stops11h 35m
$235
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Santa Ana to Greenville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Greenville in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Santa Ana-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Ana-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Ana-Greenville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santa Ana-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santa Ana to Greenville
Have a flexible travel schedule? Discover the best time to fly to Greenville from Santa Ana with our price prediction graph.
SNA-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santa Ana to Greenville
Reviews of airlines servicing Greenville
Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated February 28, 2026.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Santa Ana to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Food
7.2
Crew
8.5
Boarding
8.1
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Comfort
7.9
Food
7.2
Crew
8.5
Boarding
8.1
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Comfort
7.9
Food
7.2
Crew
8.5
Boarding
8.1
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Comfort
7.9
Food
7.2
Crew
8.5
Boarding
8.1
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Related info for your journey
Find useful and relevant information for your journey from Santa Ana to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Greenville?
Book flights to Greenville if you plan to visit one of these locationsSimpsonville
Duncan
Greer
Seneca
Anderson
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Other flights to Greenville
Explore flights to Greenville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 28, 2026.
Santa Ana and Greenville flights
Browse other Santa Ana and Greenville flight options. Last updated on February 28, 2026.
Other flights from Santa Ana
Browse through other flights departing from Santa Ana. Flights are based on user searches made on Cheapflights and were last updated on February 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Santa Ana to Greenville
Discover the top 3 airlines that operate flights from Santa Ana to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$324 | Average$453 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$337 | Average$459 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$434 | Average$559 | FlexibilityNo cancel fee | On-time69% |