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$163+ Cheap flights from Santa Ana to Greenville (SNA - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/8. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — GSP
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheap flight deals from Santa Ana to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2025.

Round-trip from

$304
(American Airlines)

One-way from

$163
(American Airlines)

Popular in

December

Cheapest in

August

Average price

$381
From Santa Ana J. Wayne/Orange Cnty to Greenville
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One-way flight from Santa Ana J. Wayne/Orange Cnty to Greenville
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Highest demand for flights based on searches. 9% potential increase in price ($48 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Santa Ana to Greenville

Cheapest flights from Santa Ana to Greenville
Explore the most affordable flight options available from Santa Ana to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/912:47 pmSNA - GSP
1 stop6h 43mAmerican Airlines
Sat 9/137:15 amGSP - SNA
1 stop7h 42mAmerican Airlines
Deal found 8/12$304
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/97:00 pmSNA - GSP
2 stops10h 51mUnited Airlines
Sat 9/137:00 amGSP - SNA
1 stop7h 05mUnited Airlines
Deal found 8/12$309
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/279:20 pmSNA - GSP
1 stop8h 39mDelta
Sat 11/17:30 amGSP - SNA
2 stops12h 09mDelta
Deal found 8/14$330
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/251:52 pmSNA - GSP
1 stop7h 00mDelta
Sun 9/287:35 amGSP - SNA
1 stop6h 28mDelta
Deal found 8/13$331
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/75:05 pmSNA - GSP
2 stops13h 55mSouthwest
Sat 10/1110:30 amGSP - SNA
2 stops10h 30mSouthwest
Deal found 8/14$335
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/710:23 amSNA - GSP
1 stop8h 34mAmerican Airlines
Sat 10/117:19 amGSP - SNA
1 stop9h 42mAmerican Airlines
Deal found 8/14$350
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2712:43 pmSNA - GSP
1 stop6h 56mAmerican Airlines
Sat 11/17:20 amGSP - SNA
1 stop9h 49mAmerican Airlines
Deal found 8/14$371
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/239:20 pmSNA - GSP
1 stop8h 39mDelta
Mon 10/279:54 amGSP - SNA
2 stops13h 14mDelta
Deal found 8/14$377
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:35 pmSNA - GSP
2 stops12h 14mUnited Airlines
Wed 9/174:59 pmGSP - SNA
1 stop7h 34mUnited Airlines
Deal found 8/13$379

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Ana to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Santa Ana to Greenville that are best for you.

Fly from

Santa Ana

Fly to

Greenville

Route

Depart

Return

Price

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 9/9

12:47 pm-10:30 pm

1 stop6h 43m

Greenville

Sat 9/13

7:15 am-11:57 am

1 stop7h 42m

$304

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 9/9

7:00 pm-8:51 am

2 stops10h 51m

Greenville

Sat 9/13

7:00 am-11:05 am

1 stop7h 05m

$309

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Mon 10/27

9:20 pm-8:59 am

1 stop8h 39m

Greenville

Sat 11/1

7:30 am-4:39 pm

2 stops12h 09m

$330

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 9/25

1:52 pm-11:52 pm

1 stop7h 00m

Greenville

Sun 9/28

7:35 am-11:03 am

1 stop6h 28m

$331

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 10/7

5:05 pm-10:00 am

2 stops13h 55m

Greenville

Sat 10/11

10:30 am-6:00 pm

2 stops10h 30m

$335

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Mon 10/27

6:30 pm-10:00 am

2 stops12h 30m

Greenville

Sat 11/1

10:30 am-6:05 pm

2 stops10h 35m

$335

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 10/7

10:23 am-9:57 pm

1 stop8h 34m

Greenville

Sat 10/11

7:19 am-2:01 pm

1 stop9h 42m

$350

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Mon 10/27

12:43 pm-10:39 pm

1 stop6h 56m

Greenville

Sat 11/1

7:20 am-2:09 pm

1 stop9h 49m

$371

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 10/23

9:20 pm-8:59 am

1 stop8h 39m

Greenville

Mon 10/27

9:54 am-8:08 pm

2 stops13h 14m

$377

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 9/10

6:35 pm-9:49 am

2 stops12h 14m

Greenville

Wed 9/17

4:59 pm-9:33 pm

1 stop7h 34m

$379

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Showing 1-10 of 15 results
1
2

Best time to book a flight from Santa Ana to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Santa Ana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Greenville

What is the cheapest month to book a flight from Santa Ana to Greenville?

Currently, January is the cheapest month in which you can book a flight from Santa Ana to Greenville (average of $329). Flying from Santa Ana to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SNA to GSP?

Find hourly flight availability from Santa Ana to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

When flying from Santa Ana to Greenville, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 2% versus a flight in the afternoon.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated August 14, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Santa Ana to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,244 reviews
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
8.0
Very good
7,980 reviews
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,916 reviews
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Santa Ana to Greenville round-trip?

    Delta, at $332, was found to be the cheapest airline from Santa Ana to Greenville.Alternate airlines to your destination round-trip include American Airlines and United Airlines. These flights start at 27% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Santa Ana to Greenville one-way?

    $163 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Southwest and Delta, with prices starting from $214 and $215, respectively.

  • Can I find deals for flights from Santa Ana to Greenville that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Greenville.

  • Can I find deals for business class flights from Santa Ana to Greenville?

    Yes. Cheapflights offers flight deals from Santa Ana to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana to Greenville?

    Currently, January is the cheapest month in which you can book a flight from Santa Ana to Greenville (average of $329). Flying from Santa Ana to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

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Top 4 airlines flying from Santa Ana to Greenville

Discover the top 4 airlines that operate flights from Santa Ana to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$332Average$464FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$346Average$450FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$361Average$526FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$388Average$781FlexibilityNo cancel feeOn-time63%

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