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$143+ Cheap flights from Santa Ana, CA to Greenville (SNA - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — GSP
Nov 21 — Nov 281
Fri 11/21
Fri 11/28
1 adult, Economy
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Cheap flight deals from Santa Ana to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$377
(Delta)

One-way from

$143
(United Airlines)

Popular in

December

Cheapest in

July

Average price

$544
Provider with most accurate pricing for Santa Ana J. Wayne/Orange Cnty-Greenville flight deals.
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Provider most trusted by Cheapflights users for Santa Ana J. Wayne/Orange Cnty-Greenville flights.
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From Santa Ana J. Wayne/Orange Cnty to Greenville
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One-way flight from Santa Ana J. Wayne/Orange Cnty to Greenville
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Highest demand for flights based on searches. 9% potential increase in price ($49 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Santa Ana to Greenville

Cheapest flights from Santa Ana to Greenville
Explore the most affordable flight options available from Santa Ana to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2025.

This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/239:20 pmSNA - GSP
1 stop8h 42mDelta
Wed 12/35:35 amGSP - SNA
2 stops10h 25mDelta
Deal found 10/22$377
This Mytrip deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/265:46 pmSNA - GSP
3 stops18h 56mMultiple Airlines
Mon 12/13:33 pmGSP - SNA
3 stops23h 59mMultiple Airlines
Deal found 10/21$451
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/167:25 pmSNA - GSP
2 stops11h 35mSouthwest
Sat 12/2012:20 pmGSP - SNA
2 stops11h 55mSouthwest
Deal found 10/21$458
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/177:34 pmSNA - GSP
2 stops13h 13mUnited Airlines
Wed 11/2612:23 pmGSP - SNA
1 stop9h 24mUnited Airlines
Deal found 10/20$488
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/207:50 pmSNA - GSP
2 stops11h 15mSouthwest
Thu 12/253:05 pmGSP - SNA
2 stops9h 10mSouthwest
Deal found 10/21$503
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/222:47 pmSNA - GSP
1 stop6h 05mAmerican Airlines
Tue 1/63:44 pmGSP - SNA
1 stop7h 18mAmerican Airlines
Deal found 10/22$507
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2312:27 pmSNA - GSP
2 stops8h 31mAmerican Airlines
Wed 12/36:01 amGSP - SNA
2 stops9h 37mAmerican Airlines
Deal found 10/20$512
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2412:14 pmSNA - GSP
1 stop6h 45mUnited Airlines
Fri 11/286:45 amGSP - SNA
1 stop7h 32mUnited Airlines
Deal found 10/21$518
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/163:01 pmSNA - GSP
1 stop6h 17mAmerican Airlines
Sat 12/208:01 pmGSP - SNA
1 stop16h 31mAmerican Airlines
Deal found 10/21$525
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:55 pmSNA - GSP
2 stops11h 10mSouthwest
Tue 1/611:15 amGSP - SNA
2 stops9h 40mSouthwest
Deal found 10/22$529

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Ana to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 22, 2025.
Use the filters below to find and compare flights from Santa Ana to Greenville that are best for you.

Fly from

Santa Ana

Fly to

Greenville

Route

Depart

Return

Price

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 3/3

12:52 pm-9:41 pm

1 stop5h 49m

Greenville

Wed 3/4

2:32 pm-8:24 pm

1 stop8h 52m

$387

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 12/16

7:25 pm-10:00 am

2 stops11h 35m

Greenville

Sat 12/20

12:20 pm-9:15 pm

2 stops11h 55m

$458

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 12/20

7:50 pm-10:05 am

2 stops11h 15m

Greenville

Thu 12/25

3:05 pm-9:15 pm

2 stops9h 10m

$503

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Mon 12/22

2:47 pm-11:52 pm

1 stop6h 05m

Greenville

Tue 1/6

3:44 pm-8:02 pm

1 stop7h 18m

$507

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sun 11/23

12:27 pm-11:58 pm

2 stops8h 31m

Greenville

Wed 12/3

6:01 am-12:38 pm

2 stops9h 37m

$512

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Mon 12/22

7:55 pm-10:05 am

2 stops11h 10m

Greenville

Tue 1/6

11:15 am-5:55 pm

2 stops9h 40m

$529

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 12/16

9:30 am-11:08 pm

2 stops10h 38m

Greenville

Sat 12/20

8:01 pm-9:32 am

1 stop16h 31m

$530

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sun 11/23

9:20 pm-9:02 am

1 stop8h 42m

Greenville

Wed 11/26

5:16 pm-10:19 pm

1 stop8h 03m

$542

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 11/4

12:26 pm-10:18 pm

1 stop6h 52m

Greenville

Sat 11/8

6:00 am-11:16 am

1 stop8h 16m

$547

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Fri 10/31

12:14 pm-9:59 pm

1 stop6h 45m

$143

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/20

Showing 1-10 of 14 results
1
2

Compare providers for flights from Santa Ana to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Greenville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santa Ana, California-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Ana, California-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Ana, California-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Ana to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Santa Ana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Greenville

What is the cheapest month to book a flight from Santa Ana, California to Greenville?

Currently, January is the cheapest month in which you can book a flight from Santa Ana, California to Greenville (average of $42). Flying from Santa Ana, California to Greenville in March is currently the most expensive (average of $227). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SNA to GSP?

Find hourly flight availability from Santa Ana to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 22, 2025.

When flying from Santa Ana, California to Greenville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 4% versus a flight in the evening.

How much does it cost to fly round-trip from Santa Ana, California to Greenville?

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated October 22, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Santa Ana to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,981 reviews

Overall

7.9

Boarding

8.2

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Delta
7.9
Good
7,981 reviews
Delta
7.9
Good
7,981 reviews

Overall

7.9

Boarding

8.2

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
United Airlines
7.4
Good
8,990 reviews
Delta
7.9
Good
7,981 reviews

Overall

7.9

Boarding

8.2

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
American Airlines
7.2
Good
11,028 reviews
Delta
7.9
Good
7,981 reviews

Overall

7.9

Boarding

8.2

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Ana, California to Greenville?

    A quick flight from Santa Ana, California to Greenville can take about 5h 49m. American Airlines provides one of the quickest options available for as low as $387. The distance from Santa Ana, California to Greenville is about 2025 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Santa Ana, California to Greenville round-trip?

    According to our current data, American Airlines ($336), Delta ($337), and United Airlines ($426) offers the cheapest pricing from Santa Ana, California to Greenville. American Airlines is priced at 29% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Santa Ana, California to Greenville one-way?

    The cheapest airline one-way is United Airlines, with whom users have recently found tickets for as low as $143. However, be on the lookout for offers from Southwest and American Airlines, as they are both options that can get you from Santa Ana, California to Greenville for a low price.

  • Can I find deals for flights from Santa Ana to Greenville that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Greenville.

  • Can I find deals for business class flights from Santa Ana to Greenville?

    Yes. Cheapflights offers flight deals from Santa Ana to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana, California to Greenville?

    Currently, January is the cheapest month in which you can book a flight from Santa Ana, California to Greenville (average of $42). Flying from Santa Ana, California to Greenville in March is currently the most expensive (average of $227). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

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Top 3 airlines flying from Santa Ana to Greenville

Discover the top 3 airlines that operate flights from Santa Ana to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$336Average$456FlexibilityNo cancel feeOn-time71%
DeltaCheapest$337Average$460FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$426Average$559FlexibilityNo cancel feeOn-time69%

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