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$261+ Cheap flights from Medford to Greenville (MFR - GSP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/24. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — GSP
Jul 5 — Jul 121
Sat 7/5
Sat 7/12
1 adult, Economy
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Cheap flight deals from Medford to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 30, 2025.

Round-trip from

$261
(Delta)

Popular in

November

Cheapest in

January

Average price

$513
From Medford to Greenville
Search Deals
Highest demand for flights based on searches. 29% potential increase in price ($222 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 11% potential price decrease ($56 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2025
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Find flight deals from Medford to Greenville

Cheapest flights from Medford to Greenville
Explore the most affordable flight options available from Medford to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 30, 2025.

This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/246:15 amMFR - GSP
2 stops11h 52mDelta
Wed 10/12:33 pmGSP - MFR
2 stops11h 17mDelta
Deal found 6/30$261
This United Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/235:00 amMFR - GSP
1 stop6h 58mUnited Airlines
Tue 8/264:30 pmGSP - MFR
1 stop7h 34mUnited Airlines
Deal found 6/29$351
This American Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/245:30 amMFR - GSP
2 stops14h 00mAmerican Airlines
Wed 10/19:00 amGSP - MFR
2 stops13h 16mAmerican Airlines
Deal found 6/29$355

Cheapflights Fare Finder

Customize your flight search to find flights from Medford to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 30, 2025.
Use the filters below to find and compare flights from Medford to Greenville that are best for you.

Fly from

Medford

Fly to

Greenville

Route

Depart

Return

Price

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Wed 9/24

6:15 am-9:07 pm

2 stops11h 52m

Greenville

Wed 10/1

2:33 pm-10:50 pm

2 stops11h 17m

$261

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Sat 8/23

5:00 am-2:58 pm

1 stop6h 58m

Greenville

Tue 8/26

4:30 pm-9:04 pm

1 stop7h 34m

$351

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Wed 9/24

5:30 am-10:30 pm

2 stops14h 00m

Greenville

Wed 10/1

9:00 am-7:16 pm

2 stops13h 16m

$355

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Best time to book a flight from Medford to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to Greenville

What is the cheapest month to book a flight from Medford to Greenville?

Currently, January is the cheapest month in which you can book a flight from Medford to Greenville (average of $329). Flying from Medford to Greenville in March is currently the most expensive (average of $385). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated June 30, 2025.
Read through reviews of airlines operating flights from Medford to Greenville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,973 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,973 reviews
Delta
8.0
Very good
7,973 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,852 reviews
Delta
8.0
Very good
7,973 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,973 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Medford to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Medford to Greenville round-trip?

    Our cheapest airline available from Medford to Greenville is Delta. Our recent data shows that you can find tickets from as low as $261 on this airline. Additional options worth looking into are United Airlines and American Airlines, starting at $351 and $355 round-trip. Delta is 50% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Medford to Greenville that include hotel bookings?

    Yes. In addition to deals on Medford to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to Greenville.

  • Can I find deals for business class flights from Medford to Greenville?

    Yes. Cheapflights offers flight deals from Medford to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Medford to Greenville?

    Currently, January is the cheapest month in which you can book a flight from Medford to Greenville (average of $329). Flying from Medford to Greenville in March is currently the most expensive (average of $385). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Medford?

Book flights to Medford if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

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Top 2 airlines flying from Medford to Greenville

Discover the top 2 airlines that operate flights from Medford to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$254Average$574FlexibilityNo cancel feeOn-time69%
DeltaCheapest$274Average$369FlexibilityNo cancel feeOn-timeN/A

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