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South Carolina

$253+ Cheap flights from Medford (MFR) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/1. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — CHS
Jun 8 — Jun 151
Mon 6/8
Mon 6/15
1 adult, Economy
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Cheap flight deals from Medford to South Carolina

Cheapest flights from Medford to South Carolina
Explore the most affordable flight options available from Medford to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 9, 2026.

This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:26 pm
MFR
-
CLT
2 stops13h 09m
United Airlines
Mon 8/174:15 pm
CLT
-
MFR
1 stop8h 01m
United Airlines
Deal found 5/6$374
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:01 am
MFR
-
CLT
2 stops11h 24m
Delta
Mon 8/175:30 am
CLT
-
MFR
2 stops10h 28m
Delta
Deal found 5/6$389
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:15 am
MFR
-
CLT
1 stop8h 37m
Delta
Mon 6/86:00 am
CLT
-
MFR
2 stops10h 01m
Delta
Deal found 5/5$399
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:15 am
MFR
-
CLT
1 stop8h 12m
Delta
Sat 5/305:37 pm
CLT
-
MFR
1 stop7h 58m
Delta
Deal found 5/6$409
This Delta deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:15 am
MFR
-
CLT
1 stop8h 12m
Delta
Wed 5/276:02 pm
CLT
-
MFR
1 stop8h 40m
Delta
Deal found 5/8$484
This United Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:26 pm
MFR
-
CLT
2 stops12h 16m
United Airlines
Tue 9/2210:23 am
CLT
-
MFR
2 stops13h 53m
United Airlines
Deal found 5/7$499
This Alaska Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:08 am
MFR
-
GSP
2 stops12h 48m
Alaska Airlines
Tue 6/91:37 pm
GSP
-
MFR
2 stops13h 22m
Alaska Airlines
Deal found 5/5$629
This United Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:00 am
MFR
-
GSP
1 stop7h 19m
United Airlines
Tue 6/97:40 pm
GSP
-
MFR
2 stops19h 22m
United Airlines
Deal found 5/7$755
This Alaska Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:45 am
MFR
-
CAE
2 stops15h 10m
Alaska Airlines
Sun 5/241:45 pm
CAE
-
MFR
2 stops11h 54m
Alaska Airlines
Deal found 5/5$803
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/225:20 am
MFR
-
CAE
2 stops10h 31m
Delta
Fri 6/263:54 pm
CAE
-
MFR
2 stops11h 03m
Delta
Deal found 5/4$1,257
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:00 am
MFR
-
CAE
3 stops12h 56m
United Airlines
Sun 5/246:33 am
CAE
-
MFR
2 stops9h 27m
United Airlines
Deal found 5/5$1,443
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/225:00 am
MFR
-
CAE
3 stops13h 16m
United Airlines
Fri 6/262:18 pm
CAE
-
MFR
2 stops11h 41m
United Airlines
Deal found 5/4$2,068

Find flight deals from Medford to South Carolina

Keep the following information in mind while searching for Medford to South Carolina flight deals. Data was last updated May 9, 2026.

Round-trip from

$374
(United Airlines)

One-way from

$253
(Kiwi.com)
From Medford to South Carolina
Search Deals
One-way flight from Medford to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 9, 2026.
Use the filters below to find and compare flights from Medford to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Tue 8/11

6:01 am-8:25 pm

2 stops11h 24m

Charlotte Douglas

Mon 8/17

5:30 am-12:58 pm

2 stops10h 28m

$389
Quickest round-trip

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Fri 6/5

5:15 am-4:52 pm

1 stop8h 37m

Charlotte Douglas

Mon 6/8

6:00 am-1:01 pm

2 stops10h 01m

$399

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Sat 5/23

6:15 am-8:18 pm

2 stops11h 03m

Charlotte Douglas

Wed 5/27

6:02 pm-11:42 pm

1 stop8h 40m

$489

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Sat 9/19

1:08 pm-11:09 pm

1 stop7h 01m

Charlotte Douglas

Tue 9/22

10:23 am-9:16 pm

2 stops13h 53m

$494

MedfordCharlotte

MFR - CLT

MFRCLT

Medford

Sun 6/28

5:25 pm-10:22 am

2 stops13h 57m

Charlotte Douglas

Thu 7/9

6:10 pm-11:54 pm

1 stop8h 44m

$617

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Thu 6/4

7:08 am-10:56 pm

2 stops12h 48m

Greenville

Tue 6/9

1:37 pm-11:59 pm

2 stops13h 22m

$629

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Thu 6/4

5:00 am-3:19 pm

1 stop7h 19m

Greenville

Tue 6/9

7:40 pm-12:02 pm

2 stops19h 22m

$755

MedfordColumbia

MFR - CAE

MFRCAE

Medford

Wed 5/20

5:45 am-11:55 pm

2 stops15h 10m

Columbia Metropolitan

Sun 5/24

1:45 pm-10:39 pm

2 stops11h 54m

$803

MedfordColumbia

MFR - CAE

MFRCAE

Medford

Mon 6/22

5:20 am-6:51 pm

2 stops10h 31m

Columbia Metropolitan

Fri 6/26

3:54 pm-11:57 pm

2 stops11h 03m

$1,257

MedfordColumbia

MFR - CAE

MFRCAE

Medford

Wed 5/20

5:00 am-8:56 pm

3 stops12h 56m

Columbia Metropolitan

Sun 5/24

6:33 am-1:00 pm

2 stops9h 27m

$1,443

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/6

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Best time to book a flight from Medford to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to South Carolina
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated May 9, 2026.
Get a feel of what it's like to fly with United Airlines from Medford to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,692 reviews

Boarding

7.7

Comfort

7.3

Crew

8.1

Entertainment

7.1

Overall

7.4

Food

6.6

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.
United Airlines
7.4
Good
9,692 reviews
United Airlines
7.4
Good
9,692 reviews

Boarding

7.7

Comfort

7.3

Crew

8.1

Entertainment

7.1

Overall

7.4

Food

6.6

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.

Related info for your journey

Find useful and relevant information for your journey from Medford to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Medford to South Carolina?

    Medford (MFR), located 3.0 mi from the city center, is the airport you fly out of when you book flights from Medford to South Carolina.

  • How long is the flight from Medford to South Carolina?

    Airlines like Delta, Alaska Airlines, and United Airlines fly from Medford to South Carolina in about 7h 19m. The time it takes to get you to your destination can typically vary by up to 5h 29m. Airlines will cover a distance of 2230 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Medford to South Carolina one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $124. Aeromexico flights start at $126 while deals on Alaska Airlines start at $150 one-way.

  • What are the most popular routes from Medford to South Carolina?

    The most popular flight routes from Medford to South Carolina are Medford - Charlotte Douglas, Medford - Greenville and Medford - Columbia Metropolitan.

  • Can I find deals for flights from Medford to South Carolina that include hotel bookings?

    Yes. In addition to deals on Medford to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to South Carolina.

  • Can I find deals for business class flights from Medford to South Carolina?

    Yes. Cheapflights offers flight deals from Medford to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Medford to South Carolina

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Top airline flying from Medford to South Carolina

Discover the top airline that operate flights from Medford to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 9, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$360Average$698FlexibilityNo cancel feeOn-time69%

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