$400+ Cheap flights from Medford (MFR) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/11. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — CHS
Oct 27 — Nov 31
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Medford to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Medford to South Carolina
Cheapest
Best
Last-minute
One-way
Cheapest flights from Medford to South CarolinaExplore the most affordable flight options available from Medford to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 27, 2026.
Explore the most affordable flight options available from Medford to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 27, 2026.
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:15 am -
2 stops12h 06m
Sat 11/145:40 am -
2 stops10h 11m
Deal found 9/22![Delta logo]()
$403
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:25 pm -
2 stops13h 45m
Wed 10/145:30 am -
2 stops10h 10m
Deal found 9/24![Delta logo]()
$509
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:00 am -
2 stops13h 21m
Wed 10/144:13 pm -
1 stop8h 01m
Deal found 9/24![United Airlines logo]()
$521
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:01 am -
1 stop7h 02m
Sat 11/144:29 pm -
1 stop7h 49m
Deal found 9/22![United Airlines logo]()
$523
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:13 am -
2 stops12h 28m
Fri 10/211:32 am -
2 stops14h 45m
Deal found 9/23![Delta logo]()
$577
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:45 pm -
2 stops11h 17m
Sun 11/84:29 pm -
1 stop7h 49m
Deal found 9/27![United Airlines logo]()
$588
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:11 am -
2 stops12h 16m
Sun 11/85:40 am -
2 stops10h 00m
Deal found 9/27![Delta logo]()
$619
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:29 pm -
2 stops13h 38m
Sat 10/33:56 pm -
2 stops8h 58m
Deal found 9/23![Delta logo]()
$627
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:00 am -
1 stop7h 02m
Sat 10/34:00 pm -
1 stop8h 14m
Deal found 9/23![United Airlines logo]()
$685
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:00 am -
1 stop7h 02m
Wed 9/3010:38 am -
2 stops13h 36m
Deal found 9/23![United Airlines logo]()
$690
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:00 am -
1 stop7h 02m
Thu 10/110:38 am -
2 stops13h 36m
Deal found 9/23![United Airlines logo]()
$702
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/262:08 pm -
3 stops16h 36m
Fri 10/210:23 am -
2 stops15h 24m
Deal found 9/23![United Airlines logo]()
$713
Best flights from Medford to South CarolinaDiscover carefully curated flight deals from Medford to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 27, 2026.
Discover carefully curated flight deals from Medford to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 27, 2026.
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:11 am -
2 stops13h 40m
Sat 11/145:40 am -
2 stops9h 10m
Deal found 9/26![Delta logo]()
$403
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:00 am -
2 stops13h 21m
Wed 10/144:13 pm -
1 stop8h 01m
Deal found 9/24![United Airlines logo]()
$521
This Alaska Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/216:14 pm -
1 stop20h 04m
Sun 3/286:14 pm -
1 stop9h 19m
Deal found 9/23![Alaska Airlines logo]()
$693
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:01 am -
1 stop7h 02m
Sat 11/144:29 pm -
1 stop7h 49m
Deal found 9/24![United Airlines logo]()
$523
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/306:00 am -
2 stops9h 50m
Wed 2/37:00 am -
2 stops15h 55m
Deal found 9/26![United Airlines logo]()
$527
This Alaska Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1010:33 am -
1 stop28h 22m
Wed 10/146:59 pm -
1 stop17h 57m
Deal found 9/24![Alaska Airlines logo]()
$786
This Priceline deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:37 pm -
2 stops13h 08m
Tue 10/1311:55 am -
2 stops13h 53m
Deal found 9/23![Alaska Airlines logo]()
$1,251
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:28 pm -
3 stops12h 16m
Tue 10/1310:38 am -
2 stops13h 36m
Deal found 9/23![United Airlines logo]()
$1,395
Last-minute flights from Medford to South CarolinaDiscover last-minute flight deals from Medford to South Carolina. Data last updated September 27, 2026 and is based on user searches.
Discover last-minute flight deals from Medford to South Carolina. Data last updated September 27, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:28 pm -
2 stops12h 16m
Sat 10/34:00 pm -
1 stop8h 14m
Deal found 9/23![United Airlines logo]()
$742
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:13 am -
2 stops14h 15m
Fri 10/211:32 am -
2 stops14h 45m
Deal found 9/23![Delta logo]()
$743
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:00 am -
1 stop7h 09m
Mon 9/284:13 pm -
1 stop8h 01m
Deal found 9/23![United Airlines logo]()
$761
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:13 am -
2 stops12h 28m
Fri 10/211:32 am -
2 stops14h 45m
Deal found 9/23![Delta logo]()
$577
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:29 pm -
2 stops13h 38m
Sat 10/33:56 pm -
2 stops8h 58m
Deal found 9/23![Delta logo]()
$627
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:00 am -
1 stop7h 02m
Sat 10/34:00 pm -
1 stop8h 14m
Deal found 9/23![United Airlines logo]()
$685
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:00 am -
1 stop7h 02m
Fri 10/210:23 am -
2 stops15h 24m
Deal found 9/23![United Airlines logo]()
$702
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:13 am -
2 stops12h 28m
Wed 9/306:00 am -
2 stops20h 17m
Deal found 9/23![Delta logo]()
$728
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:13 am -
2 stops12h 28m
Thu 10/12:20 pm -
2 stops25h 26m
Deal found 9/23![Delta logo]()
$751
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:25 pm -
2 stops13h 45m
Wed 10/145:30 am -
2 stops10h 10m
Deal found 9/24![Delta logo]()
$509
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:00 am -
2 stops13h 21m
Wed 10/144:13 pm -
1 stop8h 01m
Deal found 9/24![United Airlines logo]()
$521
This Alaska Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1010:33 am -
1 stop28h 22m
Wed 10/146:59 pm -
1 stop17h 57m
Deal found 9/24![Alaska Airlines logo]()
$786
One-way flights from Medford to South CarolinaSearch for one-way flight options from Medford to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 27, 2026.
Search for one-way flight options from Medford to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 27, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/112:39 pm -
2 stops17h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Multiple Airlines logo]()
$400
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/115:00 am -
1 stop7h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![United Airlines logo]()
$449
Find flight deals from Medford to South Carolina
Keep the following information in mind while searching for Medford to South Carolina flight deals. Data was last updated September 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $403 (Delta) |
One-way from | $400 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Medford to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 27, 2026.
Use the filters below to find and compare flights from Medford to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
MedfordGreenville
MFR Medford - GSP Greenville
MFRGSP
Medford
Sun 10/11
2:39 pm-11:31 am
2 stops17h 52m
Greenville
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$400
MedfordGreenville
MFR Medford - GSP Greenville
MFRGSP
Medford
Sun 11/1
6:11 am-10:51 pm
2 stops13h 40m
Greenville
Sat 11/14
5:40 am-11:50 am
2 stops9h 10m
$403
Quickest round-trip
MedfordGreenville
MFR Medford - GSP Greenville
MFRGSP
Medford
Sun 10/11
5:00 am-3:08 pm
1 stop7h 08m
Greenville
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$449
MedfordCharleston
MFR Medford - CHS Charleston
MFRCHS
Medford
Sat 10/10
6:00 am-10:21 pm
2 stops13h 21m
Charleston
Wed 10/14
4:13 pm-9:14 pm
1 stop8h 01m
$521
MedfordGreenville
MFR Medford - GSP Greenville
MFRGSP
Medford
Sun 11/1
5:01 am-3:03 pm
1 stop7h 02m
Greenville
Sat 11/14
4:29 pm-9:18 pm
1 stop7h 49m
$523
MedfordGreenville
MFR Medford - GSP Greenville
MFRGSP
Medford
Sat 1/30
6:00 am-6:50 pm
2 stops9h 50m
Greenville
Wed 2/3
7:00 am-7:55 pm
2 stops15h 55m
$527
MedfordCharleston
MFR Medford - CHS Charleston
MFRCHS
Medford
Sun 3/21
6:14 pm-5:18 pm
1 stop20h 04m
Charleston
Sun 3/28
6:14 pm-12:33 am
1 stop9h 19m
$693
MedfordCharleston
MFR Medford - CHS Charleston
MFRCHS
Medford
Sat 10/10
10:33 am-5:55 pm
1 stop28h 22m
Charleston
Wed 10/14
6:59 pm-9:56 am
1 stop17h 57m
$786
MedfordMyrtle Beach
MFR Medford - MYR Myrtle Beach Intl
MFRMYR
Medford
Fri 10/9
6:37 pm-10:45 am
2 stops13h 08m
Myrtle Beach Intl
Tue 10/13
11:55 am-10:48 pm
2 stops13h 53m
$1,251
MedfordMyrtle Beach
MFR Medford - MYR Myrtle Beach Intl
MFRMYR
Medford
Fri 10/9
6:28 pm-9:44 am
3 stops12h 16m
Myrtle Beach Intl
Tue 10/13
10:38 am-9:14 pm
2 stops13h 36m
$1,395
Sorted by cheapest first
Best time to book a flight from Medford to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Medford with our price prediction graph.
MFR-GSP
MFR-CHS
MFR-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Medford to South Carolina
MFR-USSC
MFR-GSP
MFR-CHS
MFR-MYR
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 27, 2026.
Get a feel of what it's like to fly with United Airlines from Medford to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.3
Entertainment
7.1
Food
6.7
Overall
7.4
Crew
8.1
Boarding
7.7
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Comfort
7.3
Entertainment
7.1
Food
6.7
Overall
7.4
Crew
8.1
Boarding
7.7
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Related info for your journey
Find useful and relevant information for your journey from Medford to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Medford to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Medford to South Carolina by cabin class
Find flights from Medford to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Medford and South Carolina flights
Browse other Medford and South Carolina flight options. Last updated on September 27, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Medford to South Carolina flights
Consider these flights traveling from Medford to South Carolina.
Top airline flying from Medford to South Carolina
Discover the top airline that operate flights from Medford to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$384 | Average$669 | FlexibilityNo cancel fee | On-time69% |