$163+ Cheap flights from Iowa to Greenville (GSP)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/28. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GSP
Oct 6 — Oct 131
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Iowa to GreenvilleExplore the most affordable flight options available from Iowa to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
Explore the most affordable flight options available from Iowa to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:23 pm -
1 stop4h 45m
Wed 10/216:01 am -
1 stop6h 52m
Deal found 9/2![American Airlines logo]()
$271
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:00 am -
1 stop6h 41m
Sat 10/106:02 pm -
1 stop6h 56m
Deal found 9/5![American Airlines logo]()
$295
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:00 am -
1 stop5h 08m
Sat 10/178:33 pm -
1 stop4h 25m
Deal found 9/5![American Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:44 am -
1 stop6h 18m
Wed 12/27:02 am -
1 stop4h 48m
Deal found 9/2![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:40 am -
1 stop6h 10m
Sat 10/107:20 am -
2 stops10h 03m
Deal found 9/5![Delta logo]()
$320
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/71:50 pm -
1 stop6h 15m
Sat 10/105:35 pm -
1 stop5h 35m
Deal found 9/2![Southwest logo]()
$325
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:30 pm -
1 stop4h 29m
Tue 9/296:32 am -
1 stop6h 32m
Deal found 9/2![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/283:11 pm -
1 stop5h 06m
Wed 9/306:00 am -
2 stops9h 15m
Deal found 9/2![United Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:50 am -
1 stop5h 03m
Sat 9/266:11 am -
1 stop7h 54m
Deal found 9/4![American Airlines logo]()
$334
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/54:30 pm -
2 stops5h 20m
Thu 10/86:25 am -
2 stops5h 45m
Deal found 9/1![Southwest logo]()
$335
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:23 pm -
1 stop4h 45m
Mon 10/198:33 pm -
1 stop5h 05m
Deal found 9/1![American Airlines logo]()
$341
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:50 am -
2 stops12h 45m
Tue 10/131:25 pm -
2 stops9h 35m
Deal found 9/2![Southwest logo]()
$341
Best flights from Iowa to GreenvilleDiscover carefully curated flight deals from Iowa to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
Discover carefully curated flight deals from Iowa to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
1 stop4h 07m
Sat 11/141:37 pm -
1 stop6h 31m
Deal found 9/2![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:13 pm -
1 stop5h 40m
Sat 11/145:40 am -
1 stop5h 43m
Deal found 9/2![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/112:31 pm -
1 stop5h 27m
Sat 11/145:37 pm -
1 stop4h 45m
Deal found 9/2![United Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:50 am -
2 stops12h 45m
Tue 10/131:25 pm -
2 stops9h 35m
Deal found 9/1![Southwest logo]()
$341
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:22 am -
1 stop4h 10m
Wed 12/211:54 am -
1 stop4h 41m
Deal found 9/4![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:13 pm -
1 stop5h 40m
Sat 11/147:05 am -
1 stop4h 18m
Deal found 9/2![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/132:31 pm -
2 stops8h 16m
Sat 11/1410:26 am -
2 stops8h 16m
Deal found 9/2![United Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:40 am -
1 stop6h 10m
Sat 10/107:20 am -
2 stops10h 03m
Deal found 9/5![Delta logo]()
$320
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:40 am -
2 stops11h 40m
Wed 9/301:20 pm -
2 stops9h 40m
Deal found 9/2![Southwest logo]()
$361
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:27 am -
2 stops10h 46m
Tue 10/135:46 pm -
1 stop4h 37m
Deal found 9/1![United Airlines logo]()
$330
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/182:59 pm -
1 stop6h 13m
Mon 11/237:05 am -
1 stop4h 46m
Deal found 9/1![Delta logo]()
$325
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:46 pm -
2 stops9h 35m
Wed 10/218:33 pm -
1 stop4h 25m
Deal found 9/2![American Airlines logo]()
$361
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:40 pm -
1 stop4h 37m
Sat 9/262:51 pm -
2 stops8h 56m
Deal found 9/4![United Airlines logo]()
$351
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/63:35 pm -
1 stop3h 35m
Sun 11/86:40 am -
2 stops7h 25m
Deal found 9/1![Southwest logo]()
$396
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3010:00 am -
1 stop5h 54m
Wed 2/35:31 pm -
1 stop7h 00m
Deal found 9/1![United Airlines logo]()
$351
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/282:29 pm -
1 stop6h 25m
Wed 9/3011:33 am -
1 stop6h 53m
Deal found 9/4![American Airlines logo]()
$387
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:30 am -
2 stops11h 05m
Mon 10/192:10 pm -
2 stops10h 25m
Deal found 9/1![Southwest logo]()
$421
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/307:00 am -
1 stop3h 59m
Fri 1/18:00 am -
1 stop7h 11m
Deal found 9/1![Delta logo]()
$391
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:15 am -
2 stops6h 25m
Sat 10/176:40 am -
2 stops6h 20m
Deal found 9/5![Southwest logo]()
$425
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/283:11 pm -
1 stop5h 06m
Wed 9/306:00 am -
2 stops9h 15m
Deal found 9/4![United Airlines logo]()
$392
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:30 pm -
1 stop4h 25m
Sun 9/275:45 am -
1 stop4h 58m
Deal found 9/4![Delta logo]()
$434
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/93:09 pm -
1 stop4h 37m
Wed 2/105:31 pm -
1 stop7h 01m
Deal found 9/2![United Airlines logo]()
$405
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/301:02 pm -
1 stop6h 44m
Wed 2/35:31 pm -
1 stop5h 10m
Deal found 9/2![United Airlines logo]()
$405
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1412:23 pm -
1 stop4h 45m
Sun 10/188:00 am -
2 stops11h 20m
Deal found 9/4![American Airlines logo]()
$546
Last-minute flights from Iowa to GreenvilleDiscover last-minute flight deals from Iowa to Greenville. Data last updated September 6, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to Greenville. Data last updated September 6, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:30 pm -
1 stop4h 29m
Tue 9/296:32 am -
1 stop6h 32m
Deal found 9/2![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:50 am -
1 stop5h 03m
Sat 9/266:11 am -
1 stop7h 54m
Deal found 9/4![American Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:40 pm -
1 stop4h 37m
Sat 9/262:51 pm -
2 stops8h 56m
Deal found 9/4![United Airlines logo]()
$351
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/283:11 pm -
1 stop5h 06m
Wed 9/306:00 am -
2 stops9h 15m
Deal found 9/2![United Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:00 am -
1 stop6h 41m
Sat 10/106:02 pm -
1 stop6h 56m
Deal found 9/5![American Airlines logo]()
$295
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:40 am -
1 stop6h 10m
Sat 10/107:20 am -
2 stops10h 03m
Deal found 9/5![Delta logo]()
$320
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/54:30 pm -
2 stops5h 20m
Thu 10/86:25 am -
2 stops5h 45m
Deal found 9/1![Southwest logo]()
$335
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/71:50 pm -
1 stop6h 15m
Sat 10/105:35 pm -
1 stop5h 35m
Deal found 9/2![Southwest logo]()
$325
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:00 am -
1 stop5h 08m
Sat 10/178:33 pm -
1 stop4h 25m
Deal found 9/5![American Airlines logo]()
$314
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:50 am -
2 stops12h 45m
Tue 10/131:25 pm -
2 stops9h 35m
Deal found 9/2![Southwest logo]()
$341
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:23 pm -
1 stop4h 45m
Wed 10/216:01 am -
1 stop6h 52m
Deal found 9/2![American Airlines logo]()
$271
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:23 pm -
1 stop4h 45m
Mon 10/198:33 pm -
1 stop5h 05m
Deal found 9/1![American Airlines logo]()
$341
One-way flights from Iowa to GreenvilleSearch for one-way flight options from Iowa to Greenville. Find affordable one-way fares based on user searches. Data last updated September 6, 2026.
Search for one-way flight options from Iowa to Greenville. Find affordable one-way fares based on user searches. Data last updated September 6, 2026.
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/282:13 pm -
1 stop5h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![American Airlines logo]()
$163
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:40 am -
2 stops11h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Southwest logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
3 stops57h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$198
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/273:11 pm -
1 stop6h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![United Airlines logo]()
$219
This deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/283:11 pm -
1 stop5h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![United Airlines logo]()
$234
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/271:58 pm -
2 stops23h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$239
This Trip.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/119:59 am -
1 stop7h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![Allegiant Air logo]()
$263
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:40 am -
2 stops5h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![Southwest logo]()
$334
Find flight deals from Iowa to Greenville
Keep the following information in mind while searching for Iowa to Greenville flight deals. Data was last updated September 6, 2026.
Round-trip from | $271 (American Airlines) |
|---|---|
One-way from | $163 (American Airlines) |
Popular in | August |
Cheapest in | October |
Average price | $390 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 6, 2026.
Use the filters below to find and compare flights from Iowa to Greenville that are best for you.
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Route
Depart
Return
Cheapest round-trip
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Mon 9/28
5:40 am-6:20 pm
2 stops11h 40m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$194
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Mon 9/28
9:31 pm-7:49 am
3 stops57h 18m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$198
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Sun 9/27
3:11 pm-10:59 pm
1 stop6h 48m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$219
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Mon 9/28
2:13 pm-10:53 pm
2 stops7h 40m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$224
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Sun 9/27
1:58 pm-2:28 pm
2 stops23h 30m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$239
MolineGreenville
MLI Moline Quad-City - GSP Greenville
MLIGSP
Moline Quad-City
Wed 11/11
6:00 am-11:07 am
1 stop4h 07m
Greenville
Sat 11/14
1:37 pm-7:08 pm
1 stop6h 31m
$319
MolineGreenville
MLI Moline Quad-City - GSP Greenville
MLIGSP
Moline Quad-City
Fri 11/13
5:13 pm-11:53 pm
1 stop5h 40m
Greenville
Sat 11/14
5:40 am-10:23 am
1 stop5h 43m
$319
MolineGreenville
MLI Moline Quad-City - GSP Greenville
MLIGSP
Moline Quad-City
Wed 11/11
2:31 pm-8:58 pm
1 stop5h 27m
Greenville
Sat 11/14
5:37 pm-9:22 pm
1 stop4h 45m
$319
MolineGreenville
MLI Moline Quad-City - GSP Greenville
MLIGSP
Moline Quad-City
Thu 11/26
11:22 am-4:32 pm
1 stop4h 10m
Greenville
Wed 12/2
11:54 am-3:35 pm
1 stop4h 41m
$319
MolineGreenville
MLI Moline Quad-City - GSP Greenville
MLIGSP
Moline Quad-City
Mon 11/9
5:13 pm-11:53 pm
1 stop5h 40m
Greenville
Sat 11/14
7:05 am-10:23 am
1 stop4h 18m
$319
Showing 1-10 of 31 resultsSorted by cheapest first
Best time to book a flight from Iowa to Greenville
Have a flexible travel schedule? Discover the best time to fly to Greenville from Iowa with our price prediction graph.
DSM-GSP
CID-GSP
MLI-GSP
OMA-GSP
LSE-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to Greenville
USIA-GSP
DSM-GSP
CID-GSP
MLI-GSP
OMA-GSP
What is the cheapest month to book a flight from Iowa to Greenville?
Currently, February is the cheapest month in which you can book a flight from Iowa to Greenville (average of $269). Flying from Iowa to Greenville in April is currently the most expensive (average of $566). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Iowa to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Greenville?
Book flights to Greenville if you plan to visit one of these locationsGreer
Simpsonville
Greenwood
Duncan
Anderson
Seneca
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Iowa to Greenville
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Complete your trip
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Search flights from Iowa to Greenville by cabin class
Find flights from Iowa to Greenville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Greenville
Explore flights to Greenville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 6, 2026.
Iowa and Greenville flights
Browse other Iowa and Greenville flight options. Last updated on September 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Iowa to Greenville flights
Consider these flights traveling from Iowa to Greenville.
Top 3 airlines flying from Iowa to Greenville
Discover the top 3 airlines that operate flights from Iowa to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$260 | Average$526 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$268 | Average$366 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$391 | FlexibilityNo cancel fee | On-timeN/A |