$152+ Cheap flights from Iowa to Greenville (GSP)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GSP
Dec 4 — Dec 111
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to Greenville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to Greenville
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Cheapest flights from Iowa to GreenvilleExplore the most affordable flight options available from Iowa to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
Explore the most affordable flight options available from Iowa to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/42:05 pm -
1 stop6h 51m
Mon 12/77:40 pm -
1 stop4h 50m
Deal found 11/2![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/511:27 am -
2 stops11h 13m
Mon 12/75:34 pm -
1 stop4h 51m
Deal found 11/2![United Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:00 am -
1 stop5h 07m
Mon 11/238:35 pm -
1 stop4h 23m
Deal found 11/2![American Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:53 pm -
1 stop3h 54m
Sun 12/1310:57 am -
1 stop6h 52m
Deal found 11/3![Delta logo]()
$359
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/188:03 am -
2 stops9h 58m
Tue 12/15:34 pm -
1 stop5h 14m
Deal found 11/3![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1812:20 pm -
1 stop4h 46m
Tue 12/16:50 am -
1 stop6h 36m
Deal found 11/3![American Airlines logo]()
$363
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:00 am -
2 stops7h 16m
Mon 11/2311:58 am -
2 stops11h 58m
Deal found 11/2![United Airlines logo]()
$364
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:27 am -
2 stops11h 13m
Mon 12/75:34 pm -
1 stop4h 51m
Deal found 11/2![United Airlines logo]()
$365
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1710:55 am -
1 stop6h 11m
Sat 11/218:35 pm -
1 stop4h 23m
Deal found 11/1![American Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/188:03 am -
2 stops9h 58m
Mon 11/2311:58 am -
2 stops10h 37m
Deal found 11/2![United Airlines logo]()
$372
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1710:00 am -
2 stops12h 47m
Sat 11/215:37 pm -
1 stop6h 19m
Deal found 11/1![United Airlines logo]()
$374
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:20 am -
2 stops5h 55m
Mon 12/72:50 pm -
2 stops8h 15m
Deal found 11/2![Southwest logo]()
$379
Best flights from Iowa to GreenvilleDiscover carefully curated flight deals from Iowa to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
Discover carefully curated flight deals from Iowa to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/195:10 am -
1 stop4h 56m
Mon 1/257:22 pm -
1 stop4h 09m
Deal found 11/2![Delta logo]()
$315
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/169:25 am -
2 stops8h 42m
Sat 1/2312:35 pm -
2 stops9h 53m
Deal found 11/3![United Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Sat 12/55:20 am -
2 stops5h 55m
Mon 12/72:50 pm -
2 stops8h 15m
Deal found 11/2![Southwest logo]()
$379
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/243:59 pm -
1 stop5h 34m
Mon 12/288:28 pm -
1 stop4h 21m
Deal found 11/4![American Airlines logo]()
$394
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:15 am -
1 stop4h 52m
Mon 11/237:20 am -
2 stops9h 48m
Deal found 11/2![Delta logo]()
$359
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/188:03 am -
1 stop4h 27m
Mon 11/2311:58 am -
2 stops10h 37m
Deal found 11/2![United Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:15 am -
1 stop4h 52m
Mon 11/237:20 am -
2 stops9h 48m
Deal found 11/2![Delta logo]()
$359
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:00 am -
2 stops7h 16m
Mon 11/2311:58 am -
2 stops11h 58m
Deal found 11/2![United Airlines logo]()
$364
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:27 am -
2 stops11h 13m
Mon 12/75:34 pm -
1 stop4h 51m
Deal found 11/2![United Airlines logo]()
$365
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1710:00 am -
2 stops12h 47m
Sat 11/215:37 pm -
1 stop6h 19m
Deal found 11/1![United Airlines logo]()
$374
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/176:10 am -
2 stops7h 05m
Sat 2/276:00 am -
2 stops9h 27m
Deal found 11/1![United Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3011:00 am -
1 stop4h 54m
Wed 2/36:30 am -
1 stop4h 53m
Deal found 10/31![United Airlines logo]()
$391
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/71:15 pm -
1 stop6h 44m
Wed 12/96:30 am -
1 stop5h 07m
Deal found 11/3![United Airlines logo]()
$425
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/308:00 am -
1 stop7h 18m
Wed 2/36:30 am -
1 stop5h 11m
Deal found 10/31![United Airlines logo]()
$425
Last-minute flights from Iowa to GreenvilleDiscover last-minute flight deals from Iowa to Greenville. Data last updated November 4, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to Greenville. Data last updated November 4, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1710:55 am -
1 stop6h 11m
Sat 11/218:35 pm -
1 stop4h 23m
Deal found 11/1![American Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1710:00 am -
2 stops12h 47m
Sat 11/215:37 pm -
1 stop6h 19m
Deal found 11/1![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:00 am -
1 stop5h 07m
Mon 11/238:35 pm -
1 stop4h 23m
Deal found 11/2![American Airlines logo]()
$354
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/188:03 am -
2 stops9h 58m
Tue 12/15:34 pm -
1 stop5h 14m
Deal found 11/3![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1812:20 pm -
1 stop4h 46m
Tue 12/16:50 am -
1 stop6h 36m
Deal found 11/3![American Airlines logo]()
$363
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/188:03 am -
2 stops9h 58m
Mon 11/2311:58 am -
2 stops10h 37m
Deal found 11/2![United Airlines logo]()
$372
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:00 am -
2 stops7h 16m
Mon 11/2311:58 am -
2 stops11h 58m
Deal found 11/2![United Airlines logo]()
$364
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/42:05 pm -
1 stop6h 51m
Mon 12/77:40 pm -
1 stop4h 50m
Deal found 11/2![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:27 am -
2 stops11h 13m
Mon 12/75:34 pm -
1 stop4h 51m
Deal found 11/2![United Airlines logo]()
$365
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/511:27 am -
2 stops11h 13m
Mon 12/75:34 pm -
1 stop4h 51m
Deal found 11/2![United Airlines logo]()
$330
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:20 am -
2 stops5h 55m
Mon 12/72:50 pm -
2 stops8h 15m
Deal found 11/2![Southwest logo]()
$379
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:53 pm -
1 stop3h 54m
Sun 12/1310:57 am -
1 stop6h 52m
Deal found 11/3![Delta logo]()
$359
One-way flights from Iowa to GreenvilleSearch for one-way flight options from Iowa to Greenville. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
Search for one-way flight options from Iowa to Greenville. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/69:07 am -
1 stop22h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Multiple Airlines logo]()
$152
This Southwest deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/66:40 am -
2 stops15h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Southwest logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1811:53 am -
1 stop25h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![Allegiant Air logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/26:19 pm -
1 stop19h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![Allegiant Air logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:53 pm -
3 stops59h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/155:58 pm -
1 stop19h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Allegiant Air logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1811:53 am -
2 stops30h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![Multiple Airlines logo]()
$360
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/161:20 pm -
3 stops53h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Multiple Airlines logo]()
$425
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/26:50 am -
2 stops11h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![United Airlines logo]()
$506
Find flight deals from Iowa to Greenville
Keep the following information in mind while searching for Iowa to Greenville flight deals. Data was last updated November 4, 2026.
Round-trip from | $291 (Delta) |
|---|---|
One-way from | $152 (Kiwi.com) |
Popular in | August |
Cheapest in | October |
Average price | $712 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
Use the filters below to find and compare flights from Iowa to Greenville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Sun 12/6
9:07 am-8:13 am
1 stop22h 06m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$152
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Sun 12/6
6:40 am-11:00 pm
2 stops15h 20m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$208
Cedar RapidsGreenville
CID Cedar Rapids - GSP Greenville
CIDGSP
Cedar Rapids
Wed 11/18
11:53 am-2:52 pm
1 stop25h 59m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$243
Cedar RapidsGreenville
CID Cedar Rapids - GSP Greenville
CIDGSP
Cedar Rapids
Fri 11/13
7:53 pm-8:13 am
3 stops59h 20m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$259
Cedar RapidsGreenville
CID Cedar Rapids - GSP Greenville
CIDGSP
Cedar Rapids
Sun 11/15
5:58 pm-2:40 pm
1 stop19h 42m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$260
Quickest round-trip
Cedar RapidsGreenville
CID Cedar Rapids - GSP Greenville
CIDGSP
Cedar Rapids
Tue 1/19
5:10 am-11:06 am
1 stop4h 56m
Greenville
Mon 1/25
7:22 pm-10:31 pm
1 stop4h 09m
$315
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Sat 1/16
9:25 am-7:07 pm
2 stops8h 42m
Greenville
Sat 1/23
12:35 pm-9:28 pm
2 stops9h 53m
$335
Cedar RapidsGreenville
CID Cedar Rapids - GSP Greenville
CIDGSP
Cedar Rapids
Thu 11/19
5:15 am-11:07 am
1 stop4h 52m
Greenville
Mon 11/23
7:20 am-4:08 pm
2 stops9h 48m
$359
Cedar RapidsGreenville
CID Cedar Rapids - GSP Greenville
CIDGSP
Cedar Rapids
Wed 11/18
8:03 am-1:30 pm
1 stop4h 27m
Greenville
Mon 11/23
11:58 am-9:35 pm
2 stops10h 37m
$359
Cedar RapidsGreenville
CID Cedar Rapids - GSP Greenville
CIDGSP
Cedar Rapids
Wed 11/18
5:15 am-11:07 am
1 stop4h 52m
Greenville
Mon 11/23
7:20 am-4:08 pm
2 stops9h 48m
$359
Showing 1-10 of 23 resultsSorted by cheapest first
Best time to book a flight from Iowa to Greenville
Have a flexible travel schedule? Discover the best time to fly to Greenville from Iowa with our price prediction graph.
DSM-GSP
CID-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to Greenville
USIA-GSP
DSM-GSP
CID-GSP
What is the cheapest month to book a flight from Iowa to Greenville?
Currently, February is the cheapest month in which you can book a flight from Iowa to Greenville (average of $269). Flying from Iowa to Greenville in April is currently the most expensive (average of $566). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Iowa to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Greenville?
Book flights to Greenville if you plan to visit one of these locationsGreer
Simpsonville
Greenwood
Duncan
Anderson
Seneca
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Iowa to Greenville
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Complete your trip
Complete your trip to Greenville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to Greenville by cabin class
Find flights from Iowa to Greenville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Greenville
Explore flights to Greenville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 4, 2026.
Iowa and Greenville flights
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Iowa to Greenville flights
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Top 3 airlines flying from Iowa to Greenville
Discover the top 3 airlines that operate flights from Iowa to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$260 | Average$521 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$268 | Average$364 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$367 | FlexibilityNo cancel fee | On-timeN/A |