Florida Keys

$65+ Cheap flights from St. Louis (STL) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
May 9 — May 161
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Cheap flight deals from St. Louis to Florida Keys

Cheapest flights from St. Louis to Florida Keys
Explore the most affordable flight options available from St. Louis to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/24:59 pm
STL
-
EYW
1 stop15h 07m
Multiple Airlines
Fri 5/81:11 pm
EYW
-
STL
2 stops20h 44m
Multiple Airlines
Deal found 4/7$225
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/34:19 pm
STL
-
EYW
1 stop19h 57m
Multiple Airlines
Sun 6/79:16 pm
EYW
-
STL
1 stop27h 41m
Multiple Airlines
Deal found 4/7$251
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/69:59 am
STL
-
EYW
1 stop6h 24m
Delta
Wed 5/136:19 pm
EYW
-
STL
1 stop6h 40m
Delta
Deal found 4/6$253
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:12 pm
STL
-
EYW
2 stops7h 46m
American Airlines
Wed 5/136:46 pm
EYW
-
STL
1 stop6h 10m
American Airlines
Deal found 4/6$258
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/104:19 pm
STL
-
EYW
1 stop18h 08m
Multiple Airlines
Fri 5/1512:07 pm
EYW
-
STL
2 stops30h 57m
Multiple Airlines
Deal found 4/7$263
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:23 pm
STL
-
EYW
2 stops35h 43m
Multiple Airlines
Thu 5/712:05 pm
EYW
-
STL
1 stop13h 16m
Multiple Airlines
Deal found 4/6$269
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:20 am
STL
-
EYW
1 stop4h 49m
Delta
Tue 8/187:00 am
EYW
-
STL
1 stop4h 41m
Delta
Deal found 4/8$273
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/104:19 pm
STL
-
EYW
1 stop18h 08m
Multiple Airlines
Thu 5/1412:34 pm
EYW
-
STL
2 stops45h 21m
Multiple Airlines
Deal found 4/7$275
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:15 am
STL
-
MIA
Nonstop2h 54m
American Airlines
Tue 6/98:33 am
MIA
-
STL
Nonstop3h 02m
American Airlines
Deal found 4/8$275
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:33 pm
STL
-
MIA
1 stop21h 58m
Frontier
Thu 7/166:00 am
MIA
-
STL
1 stop9h 48m
Frontier
Deal found 4/5$276
This CheapOair deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/48:08 pm
STL
-
MIA
1 stop8h 25m
Frontier
Mon 6/88:03 pm
MIA
-
STL
1 stop23h 05m
Frontier
Deal found 4/5$277
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:27 pm
STL
-
MIA
1 stop28h 20m
Frontier
Sun 5/315:22 pm
MIA
-
STL
1 stop16h 33m
Frontier
Deal found 4/7$278

Find flight deals from St. Louis to Florida Keys

Keep the following information in mind while searching for St. Louis to Florida Keys flight deals. Data was last updated April 9, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$220
(Kiwi.com)

One-way from

$65
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$395
Provider with most accurate pricing for Lambert-St Louis-Miami flight deals.
Provider most trusted by Cheapflights users for Lambert-St Louis-Miami flights.
From Lambert-St Louis to Florida Keys
One-way flight from Lambert-St Louis to Florida Keys
Highest demand for flights based on searches. 5% potential increase in price ($20 potential increase over avg. RT price).
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Average for round-trip flights in April 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
Use the filters below to find and compare flights from St. Louis to Florida Keys that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Fri 7/3

1:39 pm-7:53 pm

1 stop5h 14m

Key West

Thu 7/9

6:18 pm-10:12 pm

1 stop4h 54m

$339

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Wed 5/27

10:25 am-9:10 pm

2 stops9h 45m

Miami

Wed 6/10

11:45 am-10:25 pm

2 stops11h 40m

$367

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 5/2

11:42 am-7:40 pm

1 stop6h 58m

Key West

Sat 5/9

6:19 pm-11:59 pm

1 stop6h 40m

$369

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Mon 5/4

1:02 pm-7:40 pm

1 stop5h 38m

Key West

Sat 5/9

6:19 pm-11:59 pm

1 stop6h 40m

$374

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Sat 5/2

6:20 am-5:00 pm

2 stops9h 40m

Miami

Mon 5/11

5:30 am-2:55 pm

2 stops10h 25m

$375

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Sun 6/14

3:55 pm-7:40 pm

Nonstop2h 45m

Miami

Sun 6/21

5:50 am-7:40 am

Nonstop2h 50m

$390

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Wed 4/22

1:10 pm-4:50 pm

Nonstop2h 40m

Miami

Wed 4/29

3:00 pm-4:55 pm

Nonstop2h 55m

$401

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 5/6

9:59 am-5:23 pm

1 stop6h 24m

Key West

Sun 5/10

6:19 pm-11:59 pm

1 stop6h 40m

$406

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Sun 5/10

1:15 pm-10:00 pm

2 stops7h 45m

Miami

Wed 5/13

7:00 am-3:15 pm

2 stops9h 15m

$415

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Tue 5/5

10:25 am-11:37 am

1 stop24h 12m

Miami

Wed 5/6

7:40 pm-12:24 am

1 stop5h 44m

$432

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/5

Showing 1-10 of 40 resultsSorted by cheapest first
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Best time to book a flight from St. Louis to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Florida Keys

What is the cheapest month to book a flight from St. Louis to Florida Keys?

Currently, February is the cheapest month in which you can book a flight from St. Louis to Florida Keys (average of $222). Flying from St. Louis to Florida Keys in April is currently the most expensive (average of $296). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated April 9, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from St. Louis to Florida Keys have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Comfort

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Comfort

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Comfort

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Comfort

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Comfort

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Comfort

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from St. Louis to Florida Keys?

    Located just 12.7 mi from the city center, Lambert-St Louis (STL) is the airport most travelers will use when flying to Florida Keys from St. Louis.

  • How long is the flight from St. Louis to Florida Keys?

    Departing from St. Louis to Florida Keys will take you 5h 14m. St. Louis and Florida Keys are separated by a distance of 1102 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from St. Louis to Florida Keys one-way?

    The cheapest airlines for a one-way flight from St. Louis to Florida Keys are Spirit Airlines ($59), Frontier ($75), and American Airlines ($89).

  • Can I find deals for flights from St. Louis to Florida Keys that include hotel bookings?

    Yes. In addition to deals on St. Louis to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Florida Keys.

  • Can I find deals for business class flights from St. Louis to Florida Keys?

    Yes. Cheapflights offers flight deals from St. Louis to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Florida Keys?

    Currently, February is the cheapest month in which you can book a flight from St. Louis to Florida Keys (average of $222). Flying from St. Louis to Florida Keys in April is currently the most expensive (average of $296). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for St. Louis to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from St. Louis to Florida Keys

Discover the top 3 airlines that operate flights from St. Louis to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$222Average$379FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$222Average$396FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$262Average$463FlexibilityNo cancel feeOn-time69%

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