$59+ Cheap flights from St. Louis (STL) to Florida Keys
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
Feb 28 — Mar 71
1 adult, Economy
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Cheapest flights from St. Louis to Florida KeysExplore the most affordable flight options available from St. Louis to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.
Explore the most affordable flight options available from St. Louis to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/75:42 pm
STL
- EYW
1 stop14h 24m
Multiple Airlines
Thu 2/129:46 am
EYW
- STL
1 stop15h 13m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/223:49 pm
STL
- EYW
1 stop19h 37m
Multiple Airlines
Thu 3/59:46 am
EYW
- STL
1 stop22h 16m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$219
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1811:22 am
STL
- EYW
1 stop6h 50m
American Airlines
Wed 3/257:42 pm
EYW
- STL
1 stop5h 16m
American Airlines
Deal found 1/27![American Airlines logo]()
$223
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:00 am
STL
- EYW
2 stops9h 30m
American Airlines
Wed 4/222:01 pm
EYW
- STL
1 stop6h 29m
American Airlines
Deal found 1/27![American Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/153:49 pm
STL
- EYW
1 stop19h 37m
Multiple Airlines
Thu 2/1911:01 am
EYW
- STL
2 stops20h 50m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$241
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:27 am
STL
- EYW
1 stop6h 22m
American Airlines
Tue 5/196:45 am
EYW
- STL
1 stop4h 31m
American Airlines
Deal found 1/28![American Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/283:49 pm
STL
- EYW
1 stop16h 17m
Multiple Airlines
Wed 3/412:40 pm
EYW
- STL
2 stops46h 09m
Multiple Airlines
Deal found 1/27![Multiple Airlines logo]()
$258
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:00 am
STL
- EYW
1 stop8h 57m
United Airlines
Wed 4/153:47 pm
EYW
- STL
1 stop7h 10m
United Airlines
Deal found 1/27![United Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/118:36 am
STL
- EYW
1 stop23h 30m
Multiple Airlines
Wed 4/1511:51 am
EYW
- STL
2 stops23h 39m
Multiple Airlines
Deal found 1/27![Multiple Airlines logo]()
$260
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/411:55 am
STL
- EYW
1 stop6h 47m
Delta
Tue 3/106:25 pm
EYW
- STL
1 stop6h 33m
Delta
Deal found 1/26![Delta logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2012:16 pm
STL
- MIA
1 stop11h 31m
Multiple Airlines
Sun 3/223:12 pm
MIA
- STL
1 stop23h 22m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/61:09 pm
STL
- MIA
1 stop10h 38m
Frontier
Sun 3/87:04 pm
MIA
- STL
1 stop19h 15m
Frontier
Deal found 1/28![Frontier logo]()
$290
Find flight deals from St. Louis to Florida Keys
Keep the following information in mind while searching for St. Louis to Florida Keys flight deals. Data was last updated January 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $219 (Kiwi.com) |
One-way from | $59 (Trip.com) |
Popular in | March |
Cheapest in | September |
Average price | $409 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from St. Louis to Florida Keys that are best for you.
Fly from
St. Louis
Fly to
Florida Keys
Route
Depart
Return
Price
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Sat 2/7
5:42 pm-9:06 am
1 stop14h 24m
Key West
Thu 2/12
9:46 am-11:59 pm
1 stop15h 13m
$199
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Sat 4/18
11:43 am-7:40 pm
1 stop6h 57m
Key West
Wed 4/22
6:19 pm-11:34 pm
1 stop6h 15m
$223
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Sat 4/11
6:00 am-3:57 pm
1 stop8h 57m
Key West
Wed 4/15
3:47 pm-9:57 pm
1 stop7h 10m
$259
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Wed 3/4
11:55 am-7:42 pm
1 stop6h 47m
Key West
Tue 3/10
6:25 pm-11:58 pm
1 stop6h 33m
$266
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Wed 3/4
3:49 pm-9:06 am
1 stop16h 17m
Key West
Tue 3/10
1:01 pm-9:49 am
2 stops21h 48m
$273
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Tue 2/17
6:00 am-2:40 pm
2 stops7h 40m
Key West
Tue 2/24
6:54 pm-11:48 pm
1 stop5h 54m
$284
St. LouisMiami
STL - MIA
STLMIA
Lambert-St Louis
Wed 4/1
4:25 pm-8:05 pm
Nonstop2h 40m
Miami
Tue 4/7
5:45 pm-10:35 pm
1 stop5h 50m
$289
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Sat 4/18
12:11 pm-10:36 pm
2 stops9h 25m
Key West
Tue 4/21
3:58 pm-10:24 pm
1 stop7h 26m
$291
St. LouisKey West
STL - EYW
STLEYW
Lambert-St Louis
Wed 3/4
3:49 pm-9:06 am
1 stop16h 17m
Key West
Mon 3/9
1:06 pm-11:19 pm
1 stop11h 13m
$300
St. LouisMiami
STL - MIA
STLMIA
Lambert-St Louis
Wed 5/13
11:35 am-9:55 pm
2 stops9h 20m
Miami
Wed 5/20
7:00 am-3:15 pm
2 stops9h 15m
$309
Showing 1-10 of 31 results
Best time to book a flight from St. Louis to Florida Keys
Have a flexible travel schedule? Discover the best time to fly to Florida Keys from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Florida Keys
What is the cheapest month to book a flight from St. Louis to Florida Keys?
Currently, May is the cheapest month in which you can book a flight from St. Louis to Florida Keys (average of $198). Flying from St. Louis to Florida Keys in August is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Florida Keys
Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated January 29, 2026.
See what other customers who have flown with Southwest, Delta, and American Airlines from St. Louis to Florida Keys have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for St. Louis to Florida Keys
See prices for flight routes from nearby airports that may be better suited for you.
Top 3 airlines flying from St. Louis to Florida Keys
Discover the top 3 airlines that operate flights from St. Louis to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$216 | Average$441 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$222 | Average$404 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$245 | Average$492 | FlexibilityNo cancel fee | On-time69% |