How long is the flight from St. Louis to Florida Keys?

Departing from St. Louis to Florida Keys will take you 2h 40m. St. Louis and Florida Keys are separated by a distance of 1069 mi. This flight may include one or multiple stops.

In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.

If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

What are the most popular airlines that fly from St. Louis to Florida Keys?

Before booking your flight from St. Louis to Florida Keys check out the most popular airlines for this route: American Airlines, Delta or United Airlines.

What is the cheapest time of day to fly from STL to EOA?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from St. Louis to Florida Keys as you normally would.

What airport do you fly from for flights from St. Louis to Florida Keys?

Located just 12.7 mi from the city center, Lambert-St Louis (STL) is the airport most travelers will use when flying to Florida Keys from St. Louis.

Can I find deals for flights from St. Louis to Florida Keys that include hotel bookings?

Yes. In addition to deals on St. Louis to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from St. Louis to Florida Keys?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Florida Keys.

Can I find deals for business class flights from St. Louis to Florida Keys?

Yes. Cheapflights offers flight deals from St. Louis to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$80+ Cheap Flights from St. Louis to Florida Keys

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Cheap flight deals from St. Louis to Florida Keys

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$163 (American Airlines)
One-way from	$80 (American Airlines)
Popular in	March
Cheapest in	October
Average price	$344

Provider with most accurate pricing for Lambert-St Louis-Miami flight deals.

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Provider most trusted by Cheapflights users for Lambert-St Louis-Miami flights.

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From Lambert-St Louis to Florida Keys

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One-way flight from Lambert-St Louis to Florida Keys

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Highest demand for flights based on searches. 10% potential increase in price ($46 potential increase over avg. RT price).

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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in September 2025

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Find flight deals from St. Louis to Florida Keys

Cheapest flights from St. Louis to Florida Keys
Explore the most affordable flight options available from St. Louis to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2025.

Tue 10/215:23 amSTL - MIA

Nonstop2h 47mAmerican Airlines

Tue 10/2810:01 pmMIA - STL

Nonstop2h 55mAmerican Airlines

Deal found 9/21

$163

Thu 10/2310:17 amSTL - MIA

1 stop6h 16mFrontier

Sun 10/266:43 pmMIA - STL

1 stop15h 49mFrontier

Deal found 9/22

$164

Sun 10/2610:17 amSTL - MIA

1 stop6h 16mFrontier

Fri 10/316:00 amMIA - STL

1 stop28h 07mFrontier

Deal found 9/22

$168

Tue 10/145:23 amSTL - MIA

Nonstop2h 47mAmerican Airlines

Tue 10/2110:01 pmMIA - STL

Nonstop2h 55mAmerican Airlines

Deal found 9/21

$169

Mon 10/64:00 pmSTL - MIA

1 stop7h 12mFrontier

Sat 10/115:47 pmMIA - STL

2 stops16h 35mFrontier

Deal found 9/21

$173

Wed 10/227:52 pmSTL - MIA

1 stop9h 27mFrontier

Mon 10/276:00 amMIA - STL

1 stop28h 07mFrontier

Deal found 9/21

$175

Fri 11/147:45 pmSTL - MIA

2 stops16h 03mFrontier

Sun 11/165:01 amMIA - STL

1 stop6h 11mFrontier

Deal found 9/22

$177

Sun 10/54:00 pmSTL - MIA

1 stop17h 40mFrontier

Sun 10/125:15 amMIA - STL

1 stop6h 22mFrontier

Deal found 9/21

$180

Fri 10/247:52 pmSTL - MIA

1 stop9h 27mFrontier

Fri 10/315:05 amMIA - STL

1 stop11h 52mFrontier

Deal found 9/22

$182

Thu 10/911:32 amSTL - MIA

1 stop12h 02mFrontier

Wed 10/154:05 pmMIA - STL

1 stop19h 32mFrontier

Deal found 9/21

$183

Thu 11/611:07 amSTL - MIA

2 stops21h 05mFrontier

Sun 11/95:01 amMIA - STL

1 stop6h 11mFrontier

Deal found 9/22

$185

Tue 11/119:33 amSTL - EYW

1 stop6h 50mDelta

Tue 11/186:18 pmEYW - STL

1 stop4h 40mDelta

Deal found 9/22

$223

Best flights from St. Louis to Florida Keys
Discover carefully curated flight deals from St. Louis to Florida Keys that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2025.

Mon 12/88:45 amSTL - MIA

Nonstop2h 40mSouthwest

Tue 12/164:55 pmMIA - STL

Nonstop3h 00mSouthwest

Deal found 9/21

$194

Tue 11/116:00 amSTL - MIA

1 stop4h 21mDelta

Wed 11/126:00 amMIA - STL

1 stop5h 42mDelta

Deal found 9/23

$197

Sat 2/212:32 pmSTL - EYW

2 stops8h 27mAmerican Airlines

Tue 2/247:59 pmEYW - STL

1 stop4h 47mAmerican Airlines

Deal found 9/23

$228

Tue 10/212:15 pmSTL - MIA

1 stop6h 12mDelta

Tue 10/284:35 pmMIA - STL

1 stop6h 29mDelta

Deal found 9/22

$198

Wed 10/226:55 amSTL - MIA

1 stop6h 35mSouthwest

Wed 10/2910:30 amMIA - STL

Nonstop3h 00mSouthwest

Deal found 9/22

$214

Tue 10/146:00 amSTL - MIA

1 stop4h 04mDelta

Tue 10/217:10 amMIA - STL

1 stop6h 25mDelta

Deal found 9/21

$198

Thu 1/299:38 amSTL - EYW

1 stop7h 57mAmerican Airlines

Tue 2/35:24 pmEYW - STL

1 stop7h 08mAmerican Airlines

Deal found 9/21

$241

Tue 2/1710:00 amSTL - EYW

1 stop6h 13mDelta

Wed 2/256:00 pmEYW - STL

1 stop6h 40mDelta

Deal found 9/23

$223

Tue 11/48:13 amSTL - EYW

2 stops7h 48mAmerican Airlines

Fri 11/141:23 pmEYW - STL

1 stop6h 18mAmerican Airlines

Deal found 9/23

$246

Tue 11/119:33 amSTL - EYW

1 stop6h 50mDelta

Tue 11/186:18 pmEYW - STL

1 stop4h 40mDelta

Deal found 9/22

$223

Sat 10/118:30 amSTL - MIA

1 stop7h 10mSouthwest

Sat 10/185:45 amMIA - STL

Nonstop2h 50mSouthwest

Deal found 9/21

$274

Tue 11/46:02 amSTL - EYW

1 stop8h 26mAmerican Airlines

Sat 11/88:00 amEYW - STL

1 stop6h 17mAmerican Airlines

Deal found 9/21

$266

Sat 10/115:25 pmSTL - MIA

1 stop6h 04mDelta

Sat 10/186:00 amMIA - STL

1 stop4h 15mDelta

Deal found 9/21

$224

Wed 3/182:36 pmSTL - EYW

2 stops8h 23mAmerican Airlines

Wed 3/254:00 pmEYW - STL

1 stop6h 48mAmerican Airlines

Deal found 9/22

$271

Mon 10/206:00 amSTL - MIA

1 stop6h 11mDelta

Sat 10/256:00 amMIA - STL

1 stop4h 15mDelta

Deal found 9/21

$233

Wed 11/56:52 amSTL - EYW

2 stops9h 09mAmerican Airlines

Wed 11/121:33 pmEYW - STL

2 stops10h 34mAmerican Airlines

Deal found 9/21

$275

Tue 11/118:13 amSTL - EYW

2 stops7h 48mAmerican Airlines

Tue 11/184:10 pmEYW - STL

2 stops7h 57mAmerican Airlines

Deal found 9/21

$276

Sun 11/25:00 amSTL - EYW

1 stop6h 02mDelta

Wed 11/126:18 pmEYW - STL

1 stop4h 40mDelta

Deal found 9/22

$256

Fri 11/145:17 pmSTL - MIA

1 stop6h 29mDelta

Tue 11/188:05 amMIA - STL

1 stop6h 46mDelta

Deal found 9/21

$258

Fri 10/246:00 amSTL - EYW

1 stop6h 52mAmerican Airlines

Tue 10/284:37 pmEYW - STL

1 stop7h 28mAmerican Airlines

Deal found 9/23

$284

Sat 10/255:15 pmSTL - MIA

1 stop6h 14mDelta

Sat 11/16:00 amMIA - STL

1 stop4h 15mDelta

Deal found 9/21

$258

Mon 11/37:05 amSTL - EYW

1 stop4h 57mDelta

Thu 11/137:40 amEYW - STL

1 stop6h 20mDelta

Deal found 9/23

$259

Last-minute flights from St. Louis to Florida Keys
Discover last-minute flight deals from St. Louis to Florida Keys. Data last updated September 23, 2025 and is based on user searches.

Sun 10/54:00 pmSTL - MIA

1 stop17h 40mFrontier

Sun 10/125:15 amMIA - STL

1 stop6h 22mFrontier

Deal found 9/21

$180

Mon 10/64:00 pmSTL - MIA

1 stop7h 12mFrontier

Sat 10/115:47 pmMIA - STL

2 stops16h 35mFrontier

Deal found 9/21

$173

Mon 10/67:55 pmSTL - MIA

2 stops17h 37mFrontier

Thu 10/95:15 amMIA - STL

1 stop6h 22mFrontier

Deal found 9/22

$177

Mon 10/64:00 pmSTL - MIA

1 stop7h 12mFrontier

Fri 10/105:15 amMIA - STL

1 stop6h 22mFrontier

Deal found 9/23

$193

Thu 10/911:32 amSTL - MIA

1 stop12h 02mFrontier

Wed 10/154:05 pmMIA - STL

1 stop19h 32mFrontier

Deal found 9/21

$183

Tue 10/145:23 amSTL - MIA

Nonstop2h 47mAmerican Airlines

Tue 10/2110:01 pmMIA - STL

Nonstop2h 55mAmerican Airlines

Deal found 9/21

$169

Tue 10/215:23 amSTL - MIA

Nonstop2h 47mAmerican Airlines

Tue 10/2810:01 pmMIA - STL

Nonstop2h 55mAmerican Airlines

Deal found 9/21

$163

Wed 10/227:52 pmSTL - MIA

1 stop9h 27mFrontier

Mon 10/276:00 amMIA - STL

1 stop28h 07mFrontier

Deal found 9/21

$175

Wed 10/226:00 amSTL - EYW

1 stop6h 52mAmerican Airlines

Wed 10/295:47 pmEYW - STL

1 stop7h 09mAmerican Airlines

Deal found 9/23

$241

Thu 10/2310:17 amSTL - MIA

1 stop6h 16mFrontier

Sun 10/266:43 pmMIA - STL

1 stop15h 49mFrontier

Deal found 9/22

$164

Fri 10/247:52 pmSTL - MIA

1 stop9h 27mFrontier

Fri 10/315:05 amMIA - STL

1 stop11h 52mFrontier

Deal found 9/21

$182

Sun 10/2610:17 amSTL - MIA

1 stop6h 16mFrontier

Fri 10/316:00 amMIA - STL

1 stop28h 07mFrontier

Deal found 9/22

$168

One-way flights from St. Louis to Florida Keys
Search for one-way flight options from St. Louis to Florida Keys. Find affordable one-way fares based on user searches. Data last updated September 23, 2025.

Tue 11/44:41 pmSTL - MIA

Nonstop2h 44mAmerican Airlines

Deal found 9/22

$80

Fri 11/74:56 pmSTL - MIA

1 stop23h 29mFrontier

Deal found 9/21

$83

Fri 10/314:52 pmSTL - MIA

1 stop6h 42mFrontier

Deal found 9/23

$84

Wed 10/155:23 amSTL - MIA

Nonstop2h 47mAmerican Airlines

Deal found 9/21

$90

Sat 11/18:40 pmSTL - MIA

1 stop8h 39mFrontier

Deal found 9/21

$91

Wed 10/298:40 pmSTL - MIA

1 stop8h 39mFrontier

Deal found 9/21

$92

Mon 10/2710:18 amSTL - MIA

1 stop13h 32mFrontier

Deal found 9/21

$94

Mon 10/64:00 pmSTL - MIA

1 stop21h 32mFrontier

Deal found 9/23

$96

Thu 10/210:49 amSTL - MIA

1 stop11h 38mFrontier

Deal found 9/21

$97

Tue 11/411:36 amSTL - MIA

1 stop4h 34mDelta

Deal found 9/22

$99

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to Florida Keys that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Mon 12/8

8:45 am-12:25 pm

Nonstop2h 40m

Miami

Tue 12/16

4:55 pm-6:55 pm

Nonstop3h 00m

$194

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Tue 11/11

6:00 am-11:21 am

1 stop4h 21m

Miami

Wed 11/12

6:00 am-10:42 am

1 stop5h 42m

$197

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Tue 10/21

2:15 pm-9:27 pm

1 stop6h 12m

Miami

Tue 10/28

4:35 pm-10:04 pm

1 stop6h 29m

$198

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Tue 10/14

6:00 am-11:04 am

1 stop4h 04m

Miami

Tue 10/21

7:10 am-12:35 pm

1 stop6h 25m

$198

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Wed 10/22

6:55 am-2:30 pm

1 stop6h 35m

Miami

Wed 10/29

10:30 am-12:30 pm

Nonstop3h 00m

$214

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 2/17

10:00 am-5:13 pm

1 stop6h 13m

Key West

Wed 2/25

6:00 pm-11:40 pm

1 stop6h 40m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 11/11

9:33 am-5:23 pm

1 stop6h 50m

Key West

Tue 11/18

6:18 pm-9:58 pm

1 stop4h 40m

$223

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Sat 10/11

5:25 pm-12:29 am

1 stop6h 04m

Miami

Sat 10/18

6:00 am-9:15 am

1 stop4h 15m

$224

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 2/21

2:32 pm-11:59 pm

2 stops8h 27m

Key West

Tue 2/24

7:59 pm-11:46 pm

1 stop4h 47m

$228

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Mon 10/20

6:00 am-1:11 pm

1 stop6h 11m

Miami

Sat 10/25

6:00 am-9:15 am

1 stop4h 15m

$233

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/21

Showing 1-10 of 30 results

Best time to book a flight from St. Louis to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from St. Louis with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Florida Keys

What is the cheapest month to book a flight from St. Louis to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from St. Louis to Florida Keys (average of $328). Flying from St. Louis to Florida Keys in March is currently the most expensive (average of $489). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

See what other customers who have flown with Southwest, Delta, and American Airlines from St. Louis to Florida Keys have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,244 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Southwest

8.0

Very good

4,244 reviews

Southwest

8.0

Very good

4,244 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Delta

8.0

Very good

7,973 reviews

Southwest

8.0

Very good

4,244 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,244 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Spirit Airlines

6.3

Okay

8,041 reviews

Southwest

8.0

Very good

4,244 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Frontier

5.8

Fair

3,165 reviews

Southwest

8.0

Very good

4,244 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

What airport do you fly from for flights from St. Louis to Florida Keys?
Located just 12.7 mi from the city center, Lambert-St Louis (STL) is the airport most travelers will use when flying to Florida Keys from St. Louis.
How long is the flight from St. Louis to Florida Keys?
Departing from St. Louis to Florida Keys will take you 2h 40m. St. Louis and Florida Keys are separated by a distance of 1069 mi. This flight may include one or multiple stops.
Can I find deals for flights from St. Louis to Florida Keys that include hotel bookings?
Yes. In addition to deals on St. Louis to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from St. Louis to Florida Keys?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Florida Keys.
Can I find deals for business class flights from St. Louis to Florida Keys?
Yes. Cheapflights offers flight deals from St. Louis to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from St. Louis to Florida Keys?
Currently, August is the cheapest month in which you can book a flight from St. Louis to Florida Keys (average of $328). Flying from St. Louis to Florida Keys in March is currently the most expensive (average of $489). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from St. Louis to Florida Keys

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$217	Average$456	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$245	Average$536	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$246	Average$426	FlexibilityNo cancel fee	On-time71%

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$80+ Cheap flights from St. Louis (STL) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from St. Louis to Florida Keys with Cheapflights

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Cheap flight deals from St. Louis to Florida Keys

Keep the following information in mind while searching for St. Louis to Florida Keys flight deals. Data was last updated September 23, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from St. Louis to Florida Keys

Cheapest flights from St. Louis to Florida KeysExplore the most affordable flight options available from St. Louis to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2025.

Explore the most affordable flight options available from St. Louis to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to Florida Keys that are best for you.

Best time to book a flight from St. Louis to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from St. Louis with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Florida Keys

What is the cheapest month to book a flight from St. Louis to Florida Keys?

Reviews of airlines servicing Florida Keys

See what other customers who have flown with Southwest, Delta, and American Airlines from St. Louis to Florida Keys have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from St. Louis to Florida Keys?

How long is the flight from St. Louis to Florida Keys?

Can I find deals for flights from St. Louis to Florida Keys that include hotel bookings?

How can I find direct flights from St. Louis to Florida Keys?

Can I find deals for business class flights from St. Louis to Florida Keys?

What is the cheapest month to book a flight from St. Louis to Florida Keys?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for St. Louis to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from St. Louis to Florida Keys

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Cheapest flights from St. Louis to Florida Keys
Explore the most affordable flight options available from St. Louis to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2025.