Florida Keys

$59+ Cheap flights from St. Louis (STL) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
Feb 28 — Mar 71
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Cheap flight deals from St. Louis to Florida Keys

Cheapest flights from St. Louis to Florida Keys
Explore the most affordable flight options available from St. Louis to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/75:42 pm
STL
-
EYW
1 stop14h 24m
Multiple Airlines
Thu 2/129:46 am
EYW
-
STL
1 stop15h 13m
Multiple Airlines
Deal found 1/28$199
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/223:49 pm
STL
-
EYW
1 stop19h 37m
Multiple Airlines
Thu 3/59:46 am
EYW
-
STL
1 stop22h 16m
Multiple Airlines
Deal found 1/28$219
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1811:22 am
STL
-
EYW
1 stop6h 50m
American Airlines
Wed 3/257:42 pm
EYW
-
STL
1 stop5h 16m
American Airlines
Deal found 1/27$223
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:00 am
STL
-
EYW
2 stops9h 30m
American Airlines
Wed 4/222:01 pm
EYW
-
STL
1 stop6h 29m
American Airlines
Deal found 1/27$228
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/153:49 pm
STL
-
EYW
1 stop19h 37m
Multiple Airlines
Thu 2/1911:01 am
EYW
-
STL
2 stops20h 50m
Multiple Airlines
Deal found 1/28$241
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:27 am
STL
-
EYW
1 stop6h 22m
American Airlines
Tue 5/196:45 am
EYW
-
STL
1 stop4h 31m
American Airlines
Deal found 1/28$251
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/283:49 pm
STL
-
EYW
1 stop16h 17m
Multiple Airlines
Wed 3/412:40 pm
EYW
-
STL
2 stops46h 09m
Multiple Airlines
Deal found 1/27$258
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:00 am
STL
-
EYW
1 stop8h 57m
United Airlines
Wed 4/153:47 pm
EYW
-
STL
1 stop7h 10m
United Airlines
Deal found 1/27$259
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/118:36 am
STL
-
EYW
1 stop23h 30m
Multiple Airlines
Wed 4/1511:51 am
EYW
-
STL
2 stops23h 39m
Multiple Airlines
Deal found 1/27$260
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/411:55 am
STL
-
EYW
1 stop6h 47m
Delta
Tue 3/106:25 pm
EYW
-
STL
1 stop6h 33m
Delta
Deal found 1/26$266
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2012:16 pm
STL
-
MIA
1 stop11h 31m
Multiple Airlines
Sun 3/223:12 pm
MIA
-
STL
1 stop23h 22m
Multiple Airlines
Deal found 1/28$289
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/61:09 pm
STL
-
MIA
1 stop10h 38m
Frontier
Sun 3/87:04 pm
MIA
-
STL
1 stop19h 15m
Frontier
Deal found 1/28$290

Find flight deals from St. Louis to Florida Keys

Keep the following information in mind while searching for St. Louis to Florida Keys flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$219
(Kiwi.com)

One-way from

$59
(Trip.com)

Popular in

March

Cheapest in

September

Average price

$409
Provider with most accurate pricing for Lambert-St Louis-Miami flight deals.
Provider most trusted by Cheapflights users for Lambert-St Louis-Miami flights.
From Lambert-St Louis to Florida Keys
One-way flight from Lambert-St Louis to Florida Keys
Highest demand for flights based on searches. 6% potential increase in price ($26 potential increase over avg. RT price).
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Average for round-trip flights in January 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from St. Louis to Florida Keys that are best for you.

Fly from

St. Louis

Fly to

Florida Keys

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 2/7

5:42 pm-9:06 am

1 stop14h 24m

Key West

Thu 2/12

9:46 am-11:59 pm

1 stop15h 13m

$199

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 4/18

11:43 am-7:40 pm

1 stop6h 57m

Key West

Wed 4/22

6:19 pm-11:34 pm

1 stop6h 15m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 4/11

6:00 am-3:57 pm

1 stop8h 57m

Key West

Wed 4/15

3:47 pm-9:57 pm

1 stop7h 10m

$259

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/4

11:55 am-7:42 pm

1 stop6h 47m

Key West

Tue 3/10

6:25 pm-11:58 pm

1 stop6h 33m

$266

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/4

3:49 pm-9:06 am

1 stop16h 17m

Key West

Tue 3/10

1:01 pm-9:49 am

2 stops21h 48m

$273

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 2/17

6:00 am-2:40 pm

2 stops7h 40m

Key West

Tue 2/24

6:54 pm-11:48 pm

1 stop5h 54m

$284

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Wed 4/1

4:25 pm-8:05 pm

Nonstop2h 40m

Miami

Tue 4/7

5:45 pm-10:35 pm

1 stop5h 50m

$289

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 4/18

12:11 pm-10:36 pm

2 stops9h 25m

Key West

Tue 4/21

3:58 pm-10:24 pm

1 stop7h 26m

$291

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/4

3:49 pm-9:06 am

1 stop16h 17m

Key West

Mon 3/9

1:06 pm-11:19 pm

1 stop11h 13m

$300

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Wed 5/13

11:35 am-9:55 pm

2 stops9h 20m

Miami

Wed 5/20

7:00 am-3:15 pm

2 stops9h 15m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Showing 1-10 of 31 results
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Best time to book a flight from St. Louis to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Florida Keys

What is the cheapest month to book a flight from St. Louis to Florida Keys?

Currently, May is the cheapest month in which you can book a flight from St. Louis to Florida Keys (average of $198). Flying from St. Louis to Florida Keys in August is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated January 29, 2026.
See what other customers who have flown with Southwest, Delta, and American Airlines from St. Louis to Florida Keys have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from St. Louis to Florida Keys?

    Located just 12.7 mi from the city center, Lambert-St Louis (STL) is the airport most travelers will use when flying to Florida Keys from St. Louis.

  • How long is the flight from St. Louis to Florida Keys?

    Departing from St. Louis to Florida Keys will take you 2h 40m. St. Louis and Florida Keys are separated by a distance of 1069 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from St. Louis to Florida Keys one-way?

    The cheapest airlines for a one-way flight from St. Louis to Florida Keys are Spirit Airlines ($55), Frontier ($75), and American Airlines ($89).

  • Can I find deals for flights from St. Louis to Florida Keys that include hotel bookings?

    Yes. In addition to deals on St. Louis to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Florida Keys.

  • Can I find deals for business class flights from St. Louis to Florida Keys?

    Yes. Cheapflights offers flight deals from St. Louis to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Florida Keys?

    Currently, May is the cheapest month in which you can book a flight from St. Louis to Florida Keys (average of $198). Flying from St. Louis to Florida Keys in August is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for St. Louis to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from St. Louis to Florida Keys

Discover the top 3 airlines that operate flights from St. Louis to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$441FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$222Average$404FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$245Average$492FlexibilityNo cancel feeOn-time69%

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