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$634+ Cheap flights from Moline to Florence, SC (MLI - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/15. Fares are subject to change and may not be available on all flights or dates of travel.
MLI — FLO
Apr 15 — Apr 221
Wed 4/15
Wed 4/22
1 adult, Economy
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Cheap flight deals from Moline to Florence

Cheapest flights from Moline to Florence
Explore the most affordable flight options available from Moline to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.

This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/154:24 pm
MLI
-
FLO
1 stop4h 36m
American Airlines
Mon 6/222:35 pm
FLO
-
MLI
2 stops9h 55m
American Airlines
Deal found 3/13$634
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/3012:40 pm
MLI
-
FLO
1 stop4h 10m
American Airlines
Fri 4/36:20 pm
FLO
-
MLI
1 stop4h 38m
American Airlines
Deal found 3/15$705
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/127:00 am
MLI
-
FLO
1 stop6h 10m
American Airlines
Sun 7/192:35 pm
FLO
-
MLI
2 stops10h 16m
American Airlines
Deal found 3/14$813

Find flight deals from Moline to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Moline (MLI) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 16, 2026.

Most accurate provider

Expedia
1 star

Most trusted provider

Expedia
3 stars

Round-trip from

$634
(American Airlines)
Provider with most accurate pricing for Moline Quad-City-Florence flight deals.
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Provider most trusted by Cheapflights users for Moline Quad-City-Florence flights.
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From Moline Quad-City to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Moline to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from Moline to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Mon 6/15

4:24 pm-10:00 pm

1 stop4h 36m

Florence

Mon 6/22

2:35 pm-11:30 pm

2 stops9h 55m

$634
Quickest round-trip

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Mon 3/30

12:40 pm-5:50 pm

1 stop4h 10m

Florence

Fri 4/3

6:20 pm-9:58 pm

1 stop4h 38m

$705

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Sun 7/12

7:00 am-2:10 pm

1 stop6h 10m

Florence

Sun 7/19

2:35 pm-11:51 pm

2 stops10h 16m

$813

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/13

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Moline-Florence, South Carolina flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Moline-Florence, South Carolina flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Moline-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Moline-Florence, South Carolina flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Moline-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Moline to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Moline with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Moline to Florence

What is the cheapest month to book a flight from Moline to Florence, South Carolina?

Currently, April is the cheapest month in which you can book a flight from Moline to Florence, South Carolina (average of $124). Flying from Moline to Florence, South Carolina in December is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Moline to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Moline to Florence, South Carolina?

    For as low as $634, American Airlines can have you in Florence, South Carolina from Moline in 4h 36m. The distance between Moline and Florence, South Carolina is about 772 mi.

  • Can I find deals for flights from Moline to Florence that include hotel bookings?

    Yes. In addition to deals on Moline to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Moline to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Moline to Florence.

  • Can I find deals for business class flights from Moline to Florence?

    Yes. Cheapflights offers flight deals from Moline to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Moline to Florence, South Carolina?

    Currently, April is the cheapest month in which you can book a flight from Moline to Florence, South Carolina (average of $124). Flying from Moline to Florence, South Carolina in December is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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