Florence

$228+ Cheap flights from Minneapolis to Florence, SC (MSP - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/22. Fares are subject to change and may not be available on all flights or dates of travel.
MSP — FLO
ago. 19 — ago. 261
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Cheap flight deals from Minneapolis to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Minneapolis (MSP) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated agosto 14, 2025.

Round-trip from

$475
(American Airlines)

One-way from

$228
(American Airlines)
From Minneapolis St Paul to Florence
One-way flight from Minneapolis St Paul to Florence

Find flight deals from Minneapolis to Florence

Cheapest flights from Minneapolis to Florence
Explore the most affordable flight options available from Minneapolis to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 14, 2025.

This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/126:00 amMSP - FLO
1 stop7h 04mAmerican Airlines
dom. 10/195:14 amFLO - MSP
1 stop4h 54mAmerican Airlines
Deal found 8/13$475
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/276:08 amMSP - FLO
1 stop4h 38mAmerican Airlines
dom. 8/3111:15 amFLO - MSP
1 stop6h 54mAmerican Airlines
Deal found 8/13$480
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/1211:01 amMSP - FLO
1 stop5h 11mAmerican Airlines
dom. 9/145:14 amFLO - MSP
1 stop4h 47mAmerican Airlines
Deal found 8/14$497
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/246:00 amMSP - FLO
1 stop7h 09mAmerican Airlines
sáb. 8/3011:15 amFLO - MSP
1 stop6h 53mAmerican Airlines
Deal found 8/13$500
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/164:09 pmMSP - FLO
1 stop6h 54mAmerican Airlines
sáb. 10/2511:11 amFLO - MSP
1 stop6h 59mAmerican Airlines
Deal found 8/13$528
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/175:00 amMSP - FLO
2 stops8h 04mAmerican Airlines
sáb. 10/2511:11 amFLO - MSP
2 stops8h 37mAmerican Airlines
Deal found 8/13$538
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/175:46 pmMSP - FLO
2 stops16h 00mAmerican Airlines
vie. 10/246:14 amFLO - MSP
2 stops12h 02mAmerican Airlines
Deal found 8/13$548

Cheapflights Fare Finder

 
Customize your flight search to find flights from Minneapolis to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
Use the filters below to find and compare flights from Minneapolis to Florence that are best for you.

Fly from

Minneapolis

Fly to

Florence

Route

Depart

Return

Price

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

dom. 10/12

6:00 am-2:04 pm

1 stop7h 04m

Florence

dom. 10/19

5:14 am-9:08 am

1 stop4h 54m

$475

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

mié. 8/27

6:08 am-11:46 am

1 stop4h 38m

Florence

dom. 8/31

11:15 am-5:09 pm

1 stop6h 54m

$480

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

vie. 9/12

11:01 am-5:12 pm

1 stop5h 11m

Florence

dom. 9/14

5:14 am-9:01 am

1 stop4h 47m

$497

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

dom. 8/24

6:00 am-2:09 pm

1 stop7h 09m

Florence

sáb. 8/30

11:15 am-5:08 pm

1 stop6h 53m

$500

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

jue. 10/16

4:09 pm-12:03 am

1 stop6h 54m

Florence

sáb. 10/25

11:11 am-5:10 pm

1 stop6h 59m

$528

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

mié. 10/22

7:10 pm-10:46 am

2 stops14h 36m

$228

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Best time to book a flight from Minneapolis to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Minneapolis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Minneapolis to Florence

What is the cheapest month to book a flight from Minneapolis to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Minneapolis to Florence, South Carolina (average of $366). Flying from Minneapolis to Florence, South Carolina in October is currently the most expensive (average of $489). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Minneapolis to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • Can I find deals for flights from Minneapolis to Florence that include hotel bookings?

    Yes. In addition to deals on Minneapolis to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Minneapolis to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Minneapolis to Florence.

  • Can I find deals for business class flights from Minneapolis to Florence?

    Yes. Cheapflights offers flight deals from Minneapolis to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Minneapolis to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Minneapolis to Florence, South Carolina (average of $366). Flying from Minneapolis to Florence, South Carolina in October is currently the most expensive (average of $489). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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