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Florence

$413+ Cheap flights from Manchester, NH to Florence, SC (MHT - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/12. Fares are subject to change and may not be available on all flights or dates of travel.
MHT — FLO
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Manchester to Florence

Cheapest flights from Manchester to Florence
Explore the most affordable flight options available from Manchester to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/184:00 pm
MHT
-
FLO
2 stops25h 50m
American Airlines
Mon 3/26:20 pm
FLO
-
MHT
2 stops17h 15m
American Airlines
Deal found 1/25$498
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/185:02 pm
MHT
-
FLO
1 stop6h 55m
American Airlines
Tue 3/245:58 pm
FLO
-
MHT
2 stops17h 37m
American Airlines
Deal found 1/26$510
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/196:00 am
MHT
-
FLO
2 stops11h 50m
American Airlines
Mon 3/26:20 pm
FLO
-
MHT
2 stops17h 15m
American Airlines
Deal found 1/25$543
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/175:02 pm
MHT
-
FLO
1 stop6h 06m
American Airlines
Tue 3/35:58 pm
FLO
-
MHT
2 stops6h 01m
American Airlines
Deal found 1/25$556
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/195:02 pm
MHT
-
FLO
1 stop6h 55m
American Airlines
Tue 3/35:58 pm
FLO
-
MHT
2 stops6h 01m
American Airlines
Deal found 1/25$561
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2112:21 pm
MHT
-
FLO
2 stops11h 36m
American Airlines
Tue 3/35:58 pm
FLO
-
MHT
2 stops6h 01m
American Airlines
Deal found 1/25$562
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/224:12 pm
MHT
-
FLO
2 stops7h 45m
American Airlines
Tue 3/35:58 pm
FLO
-
MHT
2 stops6h 01m
American Airlines
Deal found 1/25$567
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:00 am
MHT
-
FLO
2 stops11h 50m
American Airlines
Mon 3/236:20 pm
FLO
-
MHT
1 stop5h 39m
American Airlines
Deal found 1/26$576
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/194:00 pm
MHT
-
FLO
2 stops7h 57m
American Airlines
Tue 3/245:58 pm
FLO
-
MHT
2 stops17h 37m
American Airlines
Deal found 1/26$582
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/195:02 pm
MHT
-
FLO
1 stop6h 55m
American Airlines
Mon 3/236:20 pm
FLO
-
MHT
2 stops17h 15m
American Airlines
Deal found 1/26$583

Find flight deals from Manchester to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Manchester (MHT) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$498
(American Airlines)

One-way from

$413
(American Airlines)

Popular in

April

Cheapest in

March
Provider with most accurate pricing for Manchester-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Manchester-Florence flights.
Search Deals
From Manchester to Florence
Search Deals
One-way flight from Manchester to Florence
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($15 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Manchester to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Manchester to Florence that are best for you.

Fly from

Manchester

Fly to

Florence

Route

Depart

Return

Price

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Fri 2/20

6:00 am-5:50 pm

2 stops11h 50m

Florence

Mon 3/2

6:20 pm-11:59 pm

2 stops29h 39m

$498

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Wed 2/18

4:00 pm-5:50 pm

2 stops25h 50m

Florence

Tue 3/3

6:15 am-11:35 am

2 stops29h 20m

$498

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Wed 2/18

4:00 pm-5:50 pm

2 stops25h 50m

Florence

Mon 3/2

6:20 pm-11:35 am

2 stops17h 15m

$498

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Wed 3/18

6:00 am-5:50 pm

2 stops11h 50m

Florence

Tue 3/24

5:58 pm-11:35 am

2 stops17h 37m

$498

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Fri 3/20

5:02 pm-11:57 pm

1 stop6h 55m

Florence

Tue 3/24

5:58 pm-11:35 am

2 stops17h 37m

$543

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Thu 3/19

5:02 pm-11:57 pm

1 stop6h 55m

Florence

Tue 3/24

5:58 pm-11:35 am

2 stops17h 37m

$543

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Wed 2/18

4:00 pm-5:50 pm

2 stops25h 50m

Florence

Wed 2/25

6:15 am-11:59 pm

2 stops17h 44m

$543

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Thu 2/19

6:00 am-5:50 pm

2 stops11h 50m

Florence

Mon 3/2

6:20 pm-11:35 am

2 stops17h 15m

$543

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 2/21

5:02 pm-11:57 pm

1 stop6h 55m

Florence

Tue 3/3

5:58 pm-11:59 pm

2 stops6h 01m

$556

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Thu 2/12

5:02 pm-11:57 pm

1 stop6h 55m

$413

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Compare providers for flights from Manchester to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Manchester to Florence in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Manchester, New Hampshire-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Manchester, New Hampshire-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Manchester, New Hampshire-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Manchester, New Hampshire-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Manchester, New Hampshire-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Manchester to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Manchester with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Manchester to Florence

What is the cheapest month to book a flight from Manchester, New Hampshire to Florence, South Carolina?

Currently, August is the cheapest month in which you can book a flight from Manchester, New Hampshire to Florence, South Carolina (average of $58). Flying from Manchester, New Hampshire to Florence, South Carolina in January is currently the most expensive (average of $83). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated January 27, 2026.
Read through reviews of airlines operating flights from Manchester to Florence, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,197 reviews

Food

6.4

Overall

7.2

Crew

8.0

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,197 reviews
American Airlines
7.2
Good
11,197 reviews

Food

6.4

Overall

7.2

Crew

8.0

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Manchester to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Manchester, New Hampshire to Florence, South Carolina?

    American Airlines can get you from Manchester, New Hampshire to Florence, South Carolina in just under 11h 50m. Your travel time can differ by up to . Manchester, New Hampshire and Florence, South Carolina are separated by a distance of 751 mi.

  • What is the cheapest airline to fly from Manchester, New Hampshire to Florence, South Carolina round-trip?

    According to our current data, American Airlines ($412), offers the cheapest pricing from Manchester, New Hampshire to Florence, South Carolina.

  • Can I find deals for flights from Manchester to Florence that include hotel bookings?

    Yes. In addition to deals on Manchester to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Manchester to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Manchester to Florence.

  • Can I find deals for business class flights from Manchester to Florence?

    Yes. Cheapflights offers flight deals from Manchester to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Manchester, New Hampshire to Florence, South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Manchester, New Hampshire to Florence, South Carolina (average of $58). Flying from Manchester, New Hampshire to Florence, South Carolina in January is currently the most expensive (average of $83). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from Manchester to Florence

Discover the top airline that operate flights from Manchester to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$412Average$424FlexibilityNo cancel feeOn-time71%

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