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$513+ Cheap flights from Central America to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
SJO — FLO
Mar 14 — Mar 211
Sat 3/14
Sat 3/21
1 adult, Economy
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Cheap flight deals from Central America to Florence

Cheapest flights from Central America to Florence
Explore the most affordable flight options available from Central America to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.

This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:14 pm
PTY
-
FLO
2 stops23h 56m
American Airlines
Sat 5/302:35 pm
FLO
-
PTY
2 stops22h 39m
American Airlines
Deal found 2/9$513
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:14 pm
PTY
-
FLO
2 stops23h 56m
American Airlines
Fri 5/292:35 pm
FLO
-
PTY
2 stops22h 39m
American Airlines
Deal found 2/9$535
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/241:14 pm
PTY
-
FLO
2 stops23h 56m
American Airlines
Sat 5/302:35 pm
FLO
-
PTY
2 stops22h 39m
American Airlines
Deal found 2/9$562

Find flight deals from Central America to Florence

Keep the following information in mind while searching for Central America to Florence flight deals. Data was last updated February 12, 2026.

Round-trip from

$513
(American Airlines)
From Central America to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Central America to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Central America to Florence that are best for you.

Fly from

Central America

Fly to

Florence

Route

Depart

Return

Price

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Wed 5/27

1:14 pm-2:10 pm

2 stops23h 56m

Florence

Sat 5/30

2:35 pm-12:14 pm

2 stops22h 39m

$513

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Sat 5/23

1:14 pm-2:10 pm

2 stops23h 56m

Florence

Fri 5/29

2:35 pm-12:14 pm

2 stops22h 39m

$535

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Sun 5/24

1:14 pm-2:10 pm

2 stops23h 56m

Florence

Sat 5/30

2:35 pm-12:14 pm

2 stops22h 39m

$562

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/9

Best time to book a flight from Central America to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Central America with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Central America to Florence

What is the cheapest month to book a flight from Central America to Florence, South Carolina?

Currently, December is the cheapest month in which you can book a flight from Central America to Florence, South Carolina (average of $148). Flying from Central America to Florence, South Carolina in July is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Central America to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Central America?

    For a flight from Central America to Florence, you will be flying into Florence. Florence (FLO) is just 2.3 mi from the center of the city.

  • How long is the flight from Central America to Florence, South Carolina?

    American Airlines can get you from Central America to Florence, South Carolina in just under 23h 56m. Your travel time can differ by up to . The distance between Central America and Florence, South Carolina is about 1734 mi.

  • Can I find deals for flights from Central America to Florence that include hotel bookings?

    Yes. In addition to deals on Central America to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Central America to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Central America to Florence.

  • Can I find deals for business class flights from Central America to Florence?

    Yes. Cheapflights offers flight deals from Central America to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Central America to Florence, South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Central America to Florence, South Carolina (average of $148). Flying from Central America to Florence, South Carolina in July is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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