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$363+ Cheap flights from Central America to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/5. Fares are subject to change and may not be available on all flights or dates of travel.
SJO — FLO
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Central America to Florence

One-way flights from Central America to Florence
Search for one-way flight options from Central America to Florence. Find affordable one-way fares based on user searches. Data last updated December 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/54:05 pmPTY - FLO
2 stops31h 53mAmerican Airlines
Deal found 12/16$363
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:50 pmPTY - FLO
2 stops26h 33mAmerican Airlines
Deal found 12/16$368
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/83:13 pmPTY - FLO
2 stops49h 08mAmerican Airlines
Deal found 12/16$396
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/22:39 pmPTY - FLO
2 stops32h 33mAmerican Airlines
Deal found 12/16$407
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/62:39 pmPTY - FLO
2 stops27h 06mAmerican Airlines
Deal found 12/16$423
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/72:50 pmPTY - FLO
2 stops49h 56mAmerican Airlines
Deal found 12/16$489

Cheapflights Fare Finder

 
Customize your flight search to find flights from Central America to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Central America to Florence that are best for you.

Fly from

Central America

Fly to

Florence

Route

Depart

Return

Price

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Thu 3/5

4:05 pm-11:58 pm

2 stops31h 53m

$363

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Tue 3/3

2:50 pm-5:23 pm

2 stops26h 33m

$368

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Sun 3/8

3:13 pm-5:21 pm

2 stops49h 08m

$396

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Mon 3/2

2:39 pm-11:12 pm

2 stops32h 33m

$407

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Fri 3/6

2:39 pm-5:45 pm

2 stops27h 06m

$423

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Sat 3/7

2:50 pm-4:46 pm

2 stops49h 56m

$489

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Best time to book a flight from Central America to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Central America with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Central America to Florence

What is the cheapest month to book a flight from Central America to Florence, South Carolina?

Currently, December is the cheapest month in which you can book a flight from Central America to Florence, South Carolina (average of $148). Flying from Central America to Florence, South Carolina in July is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Central America to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Central America?

    For a flight from Central America to Florence, you will be flying into Florence. Florence (FLO) is just 2.3 mi from the center of the city.

  • Can I find deals for flights from Central America to Florence that include hotel bookings?

    Yes. In addition to deals on Central America to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Central America to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Central America to Florence.

  • Can I find deals for business class flights from Central America to Florence?

    Yes. Cheapflights offers flight deals from Central America to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Central America to Florence, South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Central America to Florence, South Carolina (average of $148). Flying from Central America to Florence, South Carolina in July is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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