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$425+ Cheap flights from Buffalo to Florence, SC (BUF - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/13. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — FLO
May 18 — May 251
Mon 5/18
Mon 5/25
1 adult, Economy
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Cheap flight deals from Buffalo to Florence

Cheapest flights from Buffalo to Florence
Explore the most affordable flight options available from Buffalo to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 18, 2026.

This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:00 am
BUF
-
FLO
2 stops14h 47m
American Airlines
Wed 5/205:20 am
FLO
-
BUF
2 stops11h 22m
American Airlines
Deal found 4/15$425
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:00 am
BUF
-
FLO
2 stops14h 47m
American Airlines
Sat 5/232:35 pm
FLO
-
BUF
1 stop4h 04m
American Airlines
Deal found 4/18$449
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2111:52 am
BUF
-
FLO
2 stops12h 21m
American Airlines
Wed 9/305:31 am
FLO
-
BUF
2 stops11h 29m
American Airlines
Deal found 4/16$503
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:30 am
BUF
-
FLO
2 stops10h 20m
American Airlines
Fri 5/222:35 pm
FLO
-
BUF
1 stop4h 06m
American Airlines
Deal found 4/15$546
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:49 am
BUF
-
FLO
2 stops9h 58m
American Airlines
Sat 5/25:20 am
FLO
-
BUF
2 stops10h 47m
American Airlines
Deal found 4/14$571
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:25 am
BUF
-
FLO
2 stops14h 22m
American Airlines
Thu 5/212:35 pm
FLO
-
BUF
1 stop4h 06m
American Airlines
Deal found 4/16$598

Find flight deals from Buffalo to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$425
(American Airlines)
Provider with most accurate pricing for Buffalo-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Florence flights.
Search Deals
From Buffalo to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
Use the filters below to find and compare flights from Buffalo to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloFlorence

BUF - FLO

BUFFLO

Buffalo

Sat 5/16

7:00 am-9:47 pm

2 stops14h 47m

Florence

Sat 5/23

2:35 pm-6:39 pm

1 stop4h 04m

$449
Quickest round-trip

BuffaloFlorence

BUF - FLO

BUFFLO

Buffalo

Wed 7/15

6:03 am-2:10 pm

2 stops8h 07m

Florence

Mon 7/20

2:35 pm-6:44 pm

1 stop4h 09m

$512

BuffaloFlorence

BUF - FLO

BUFFLO

Buffalo

Fri 5/15

5:30 am-3:50 pm

2 stops10h 20m

Florence

Fri 5/22

2:35 pm-6:41 pm

1 stop4h 06m

$546

BuffaloFlorence

BUF - FLO

BUFFLO

Buffalo

Fri 4/24

11:49 am-9:47 pm

2 stops9h 58m

Florence

Sat 5/2

5:20 am-4:07 pm

2 stops10h 47m

$571

BuffaloFlorence

BUF - FLO

BUFFLO

Buffalo

Thu 5/14

7:25 am-9:47 pm

2 stops14h 22m

Florence

Thu 5/21

5:05 am-3:44 pm

2 stops10h 39m

$605

BuffaloFlorence

BUF - FLO

BUFFLO

Buffalo

Wed 5/13

6:00 am-3:50 pm

1 stop9h 50m

Florence

Wed 5/20

5:20 am-1:05 pm

1 stop7h 45m

$726

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/18

Sorted by cheapest first

Compare providers for flights from Buffalo to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Florence in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Buffalo-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Buffalo-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Florence, South Carolina?

    Airlines like American Airlines fly from Buffalo to Florence, South Carolina in about 14h 47m. The time it takes to get you to your destination can typically vary by up to . Buffalo and Florence, South Carolina are separated by a distance of 607 mi.

  • Can I find deals for flights from Buffalo to Florence that include hotel bookings?

    Yes. In addition to deals on Buffalo to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Florence.

  • Can I find deals for business class flights from Buffalo to Florence?

    Yes. Cheapflights offers flight deals from Buffalo to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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