$407+ Cheap flights from Buffalo to Florence, SC (BUF - FLO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/13. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — FLO
Dec 8 — Dec 151
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to Florence with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Florence
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Cheapest flights from Buffalo to FlorenceExplore the most affordable flight options available from Buffalo to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 8, 2026.
Explore the most affordable flight options available from Buffalo to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 8, 2026.
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/137:36 pm -
1 stop4h 22m
Mon 12/215:09 am -
1 stop5h 31m
Deal found 11/5![American Airlines logo]()
$565
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:26 pm -
2 stops7h 33m
Sun 11/155:09 am -
1 stop5h 31m
Deal found 11/4![American Airlines logo]()
$586
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/125:47 am -
2 stops9h 26m
Mon 12/215:09 am -
1 stop5h 31m
Deal found 11/5![American Airlines logo]()
$591
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/137:36 pm -
1 stop4h 22m
Thu 12/242:35 pm -
2 stops21h 07m
Deal found 11/5![American Airlines logo]()
$600
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/155:19 am -
2 stops10h 00m
Thu 12/242:35 pm -
2 stops21h 07m
Deal found 11/5![American Airlines logo]()
$609
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:47 pm -
1 stop4h 10m
Sun 12/205:09 am -
1 stop5h 31m
Deal found 11/5![American Airlines logo]()
$614
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:00 am -
2 stops9h 13m
Thu 12/242:35 pm -
2 stops21h 07m
Deal found 11/5![American Airlines logo]()
$626
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/145:19 am -
2 stops17h 36m
Thu 12/242:35 pm -
2 stops21h 07m
Deal found 11/5![American Airlines logo]()
$635
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:47 pm -
1 stop4h 10m
Thu 12/242:35 pm -
2 stops21h 07m
Deal found 11/5![American Airlines logo]()
$649
Best flights from Buffalo to FlorenceDiscover carefully curated flight deals from Buffalo to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 8, 2026.
Discover carefully curated flight deals from Buffalo to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 8, 2026.
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/136:37 pm -
1 stop5h 20m
Wed 3/176:22 am -
1 stop5h 49m
Deal found 11/4![American Airlines logo]()
$407
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:00 am -
2 stops9h 13m
Mon 12/215:09 am -
2 stops6h 39m
Deal found 11/5![American Airlines logo]()
$674
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:00 am -
2 stops9h 19m
Tue 12/222:35 pm -
2 stops7h 23m
Deal found 11/5![American Airlines logo]()
$715
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/146:47 pm -
1 stop4h 08m
Sat 12/265:09 am -
1 stop5h 31m
Deal found 11/5![American Airlines logo]()
$724
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/146:00 am -
2 stops9h 12m
Tue 12/222:35 pm -
2 stops7h 23m
Deal found 11/5![American Airlines logo]()
$771
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:47 pm -
1 stop4h 10m
Sat 12/265:09 am -
1 stop5h 31m
Deal found 11/5![American Airlines logo]()
$773
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/187:01 pm -
2 stops19h 09m
Thu 12/242:35 pm -
2 stops21h 07m
Deal found 11/5![American Airlines logo]()
$820
Last-minute flights from Buffalo to FlorenceDiscover last-minute flight deals from Buffalo to Florence. Data last updated November 8, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Florence. Data last updated November 8, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:26 pm -
2 stops7h 33m
Sun 11/155:09 am -
1 stop5h 31m
Deal found 11/4![American Airlines logo]()
$586
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/125:47 am -
2 stops9h 26m
Mon 12/215:09 am -
1 stop5h 31m
Deal found 11/5![American Airlines logo]()
$591
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:00 am -
2 stops9h 13m
Thu 12/242:35 pm -
2 stops21h 07m
Deal found 11/5![American Airlines logo]()
$626
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/137:36 pm -
1 stop4h 22m
Mon 12/215:09 am -
1 stop5h 31m
Deal found 11/5![American Airlines logo]()
$565
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/137:36 pm -
1 stop4h 22m
Thu 12/242:35 pm -
2 stops21h 07m
Deal found 11/5![American Airlines logo]()
$600
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/145:19 am -
2 stops17h 36m
Thu 12/242:35 pm -
2 stops21h 07m
Deal found 11/5![American Airlines logo]()
$635
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/155:19 am -
2 stops10h 00m
Thu 12/242:35 pm -
2 stops21h 07m
Deal found 11/5![American Airlines logo]()
$609
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:47 pm -
1 stop4h 10m
Sun 12/205:09 am -
1 stop5h 31m
Deal found 11/5![American Airlines logo]()
$614
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:47 pm -
1 stop4h 10m
Thu 12/242:35 pm -
2 stops21h 07m
Deal found 11/5![American Airlines logo]()
$649
Find flight deals from Buffalo to Florence
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $407 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 8, 2026.
Use the filters below to find and compare flights from Buffalo to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloFlorence
BUF Buffalo - FLO Florence
BUFFLO
Buffalo
Sat 3/13
6:37 pm-11:57 pm
1 stop5h 20m
Florence
Wed 3/17
6:22 am-12:11 pm
1 stop5h 49m
$407
BuffaloFlorence
BUF Buffalo - FLO Florence
BUFFLO
Buffalo
Sat 12/12
6:00 am-3:13 pm
2 stops9h 13m
Florence
Mon 12/21
5:09 am-11:48 am
2 stops6h 39m
$674
BuffaloFlorence
BUF Buffalo - FLO Florence
BUFFLO
Buffalo
Tue 12/15
6:00 am-3:19 pm
2 stops9h 19m
Florence
Tue 12/22
2:35 pm-9:58 pm
2 stops7h 23m
$715
Quickest round-trip
BuffaloFlorence
BUF Buffalo - FLO Florence
BUFFLO
Buffalo
Mon 12/14
6:47 pm-10:55 pm
1 stop4h 08m
Florence
Sat 12/26
5:09 am-10:40 am
1 stop5h 31m
$724
BuffaloFlorence
BUF Buffalo - FLO Florence
BUFFLO
Buffalo
Mon 12/14
6:00 am-3:12 pm
2 stops9h 12m
Florence
Tue 12/22
2:35 pm-9:58 pm
2 stops7h 23m
$771
BuffaloFlorence
BUF Buffalo - FLO Florence
BUFFLO
Buffalo
Thu 12/17
7:47 pm-11:57 pm
1 stop4h 10m
Florence
Sat 12/26
5:09 am-10:40 am
1 stop5h 31m
$773
BuffaloFlorence
BUF Buffalo - FLO Florence
BUFFLO
Buffalo
Fri 12/18
7:01 pm-2:10 pm
2 stops19h 09m
Florence
Thu 12/24
2:35 pm-11:42 am
2 stops21h 07m
$820
Sorted by cheapest first
Compare providers for flights from Buffalo to Florence
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Florence in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from Buffalo with our price prediction graph.
BUF-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Book flights to Florence if you plan to visit one of these locationsSumter
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