$90+ Cheap flights from Buffalo (BUF) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/4. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
Jul 15 — Jul 221
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/27:00 am
BUF
- CHS
1 stop5h 07m
Delta
Tue 9/86:00 pm
CHS
- BUF
1 stop5h 00m
Delta
Deal found 6/11![Delta logo]()
$197
This JetBlue deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:25 am
BUF
- CHS
1 stop7h 21m
JetBlue
Wed 9/211:00 am
CHS
- BUF
1 stop7h 54m
JetBlue
Deal found 6/14![JetBlue logo]()
$202
This Justfly.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:00 am
BUF
- CHS
1 stop6h 10m
JetBlue
Wed 9/211:00 am
CHS
- BUF
1 stop7h 54m
JetBlue
Deal found 6/13![JetBlue logo]()
$206
This Expedia deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/57:57 pm
BUF
- CLT
1 stop21h 01m
Frontier
Wed 8/1212:24 pm
CLT
- BUF
1 stop28h 08m
Frontier
Deal found 6/13![Frontier logo]()
$210
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2512:56 pm
BUF
- MYR
1 stop3h 29m
American Airlines
Wed 9/26:15 am
MYR
- BUF
1 stop5h 51m
American Airlines
Deal found 6/11![American Airlines logo]()
$213
This Priceline deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/159:15 am
BUF
- SAV
1 stop8h 40m
JetBlue
Tue 7/216:51 pm
SAV
- BUF
1 stop5h 34m
JetBlue
Deal found 6/14![JetBlue logo]()
$217
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:55 am
BUF
- MYR
1 stop4h 55m
Southwest
Wed 9/27:50 am
MYR
- BUF
2 stops9h 55m
Southwest
Deal found 6/11![Southwest logo]()
$219
This Cheapflightsfares deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2910:25 am
BUF
- CHS
1 stop5h 58m
JetBlue
Tue 8/410:58 am
CHS
- BUF
1 stop7h 27m
JetBlue
Deal found 6/11![JetBlue logo]()
$221
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am
BUF
- MYR
2 stops10h 05m
Southwest
Tue 10/67:10 am
MYR
- BUF
2 stops11h 10m
Southwest
Deal found 6/10![Southwest logo]()
$230
This Justfly.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:00 am
BUF
- CHS
1 stop6h 10m
JetBlue
Wed 9/211:00 am
CHS
- BUF
1 stop7h 54m
JetBlue
Deal found 6/13![JetBlue logo]()
$230
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2210:00 am
BUF
- CHS
1 stop4h 39m
Delta
Sun 9/276:42 pm
CHS
- BUF
1 stop5h 12m
Delta
Deal found 6/11![Delta logo]()
$232
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/134:49 pm
BUF
- MYR
1 stop4h 10m
American Airlines
Tue 8/186:00 am
MYR
- BUF
1 stop4h 18m
American Airlines
Deal found 6/10![American Airlines logo]()
$234
Best flights from Buffalo to South CarolinaDiscover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
This JetBlue deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am
BUF
- CHS
1 stop6h 10m
JetBlue
Sat 9/511:00 am
CHS
- BUF
1 stop8h 03m
JetBlue
Deal found 6/11![JetBlue logo]()
$202
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2210:00 am
BUF
- CHS
1 stop4h 39m
Delta
Sun 9/276:42 pm
CHS
- BUF
1 stop5h 12m
Delta
Deal found 6/11![Delta logo]()
$232
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:01 am
BUF
- CHS
1 stop4h 06m
American Airlines
Mon 7/136:17 pm
CHS
- BUF
1 stop4h 34m
American Airlines
Deal found 6/10![American Airlines logo]()
$267
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:55 am
BUF
- CHS
1 stop7h 03m
United Airlines
Sat 9/56:30 am
CHS
- BUF
2 stops7h 48m
United Airlines
Deal found 6/10![United Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/223:30 pm
BUF
- MYR
1 stop3h 30m
Southwest
Sat 8/2911:55 am
MYR
- BUF
2 stops9h 10m
Southwest
Deal found 6/10![Southwest logo]()
$328
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/136:16 am
BUF
- CHS
1 stop4h 29m
Delta
Sat 9/196:00 am
CHS
- BUF
1 stop4h 26m
Delta
Deal found 6/11![Delta logo]()
$266
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:05 am
BUF
- CHS
1 stop4h 37m
Delta
Thu 7/96:43 pm
CHS
- BUF
1 stop5h 15m
Delta
Deal found 6/13![Delta logo]()
$267
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:00 am
BUF
- CAE
1 stop4h 09m
American Airlines
Tue 7/145:00 am
CAE
- BUF
1 stop4h 03m
American Airlines
Deal found 6/11![American Airlines logo]()
$297
This JetBlue deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/136:00 am
BUF
- SAV
1 stop7h 18m
JetBlue
Sat 9/192:20 pm
SAV
- BUF
1 stop4h 41m
JetBlue
Deal found 6/11![JetBlue logo]()
$297
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/412:30 pm
BUF
- CHS
1 stop6h 50m
Southwest
Fri 7/101:55 pm
CHS
- BUF
2 stops10h 20m
Southwest
Deal found 6/10![Southwest logo]()
$328
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/910:34 am
BUF
- CAE
2 stops10h 42m
United Airlines
Mon 7/207:45 pm
CAE
- BUF
1 stop4h 14m
United Airlines
Deal found 6/14![United Airlines logo]()
$346
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/204:59 pm
BUF
- CHS
1 stop4h 47m
Delta
Thu 11/2610:30 am
CHS
- BUF
1 stop4h 59m
Delta
Deal found 6/12![Delta logo]()
$293
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/118:00 am
BUF
- HHH
1 stop6h 15m
American Airlines
Sat 7/182:45 pm
HHH
- BUF
1 stop6h 19m
American Airlines
Deal found 6/11![American Airlines logo]()
$323
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/112:35 pm
BUF
- MYR
2 stops6h 45m
Southwest
Sun 9/66:20 pm
MYR
- BUF
1 stop4h 20m
Southwest
Deal found 6/14![Southwest logo]()
$333
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:55 am
BUF
- SAV
1 stop8h 09m
United Airlines
Wed 8/1912:59 pm
SAV
- BUF
1 stop8h 08m
United Airlines
Deal found 6/10![United Airlines logo]()
$355
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/296:25 am
BUF
- CHS
2 stops9h 45m
Southwest
Tue 8/46:45 am
CHS
- BUF
2 stops7h 35m
Southwest
Deal found 6/11![Southwest logo]()
$348
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/204:59 pm
BUF
- CHS
1 stop4h 47m
Delta
Fri 11/276:00 am
CHS
- BUF
1 stop6h 33m
Delta
Deal found 6/14![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:01 am
BUF
- CAE
1 stop4h 43m
American Airlines
Thu 7/166:01 am
CAE
- BUF
1 stop4h 39m
American Airlines
Deal found 6/10![American Airlines logo]()
$372
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:30 am
BUF
- GSP
1 stop6h 32m
United Airlines
Wed 9/22:18 pm
GSP
- BUF
1 stop6h 49m
United Airlines
Deal found 6/12![United Airlines logo]()
$383
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/512:00 pm
BUF
- CLT
2 stops9h 25m
Southwest
Wed 8/128:05 am
CLT
- BUF
2 stops9h 40m
Southwest
Deal found 6/13![Southwest logo]()
$349
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/910:21 am
BUF
- CAE
1 stop5h 01m
Delta
Thu 7/167:05 am
CAE
- BUF
1 stop6h 42m
Delta
Deal found 6/11![Delta logo]()
$322
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:00 am
BUF
- GSP
1 stop4h 15m
American Airlines
Sun 8/27:17 pm
GSP
- BUF
1 stop4h 42m
American Airlines
Deal found 6/11![American Airlines logo]()
$387
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:55 am
BUF
- HHH
1 stop7h 08m
United Airlines
Wed 9/22:48 pm
HHH
- BUF
1 stop6h 19m
United Airlines
Deal found 6/12![United Airlines logo]()
$389
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/136:16 am
BUF
- HHH
1 stop5h 07m
Delta
Sat 9/194:10 pm
HHH
- BUF
1 stop5h 10m
Delta
Deal found 6/11![Delta logo]()
$325
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/75:40 am
BUF
- MYR
2 stops9h 05m
Southwest
Mon 9/141:55 pm
MYR
- BUF
2 stops7h 55m
Southwest
Deal found 6/14![Southwest logo]()
$364
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2510:30 am
BUF
- SAV
2 stops10h 49m
United Airlines
Sat 8/298:10 am
SAV
- BUF
2 stops10h 50m
United Airlines
Deal found 6/10![United Airlines logo]()
$394
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:24 pm
BUF
- MYR
1 stop4h 31m
Delta
Mon 8/37:02 pm
MYR
- BUF
1 stop4h 57m
Delta
Deal found 6/13![Delta logo]()
$328
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/611:45 am
BUF
- GSP
2 stops8h 30m
Southwest
Tue 8/117:00 am
GSP
- BUF
2 stops7h 20m
Southwest
Deal found 6/11![Southwest logo]()
$366
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:00 am
BUF
- SAV
2 stops8h 16m
United Airlines
Fri 9/187:30 pm
SAV
- BUF
1 stop4h 14m
United Airlines
Deal found 6/11![United Airlines logo]()
$394
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/312:30 pm
BUF
- CLT
2 stops9h 20m
Southwest
Wed 9/96:50 am
CLT
- BUF
2 stops7h 30m
Southwest
Deal found 6/13![Southwest logo]()
$369
Last-minute flights from Buffalo to South CarolinaDiscover last-minute flight deals from Buffalo to South Carolina. Data last updated June 15, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated June 15, 2026 and is based on user searches.
This Cheapflightsfares deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:30 am
BUF
- CHS
1 stop7h 37m
JetBlue
Wed 7/810:58 am
CHS
- BUF
1 stop7h 58m
JetBlue
Deal found 6/10![JetBlue logo]()
$261
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:26 pm
BUF
- CHS
1 stop4h 28m
American Airlines
Wed 7/87:51 pm
CHS
- BUF
1 stop4h 08m
American Airlines
Deal found 6/11![American Airlines logo]()
$267
This Expedia deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/410:25 am
BUF
- CHS
1 stop8h 40m
JetBlue
Fri 7/108:50 pm
CHS
- BUF
1 stop11h 02m
JetBlue
Deal found 6/10![JetBlue logo]()
$256
This CheapOair deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:57 pm
BUF
- CLT
1 stop21h 01m
Frontier
Sun 7/1210:59 pm
CLT
- BUF
1 stop20h 07m
Frontier
Deal found 6/11![Frontier logo]()
$260
This Priceline deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/119:33 am
BUF
- SAV
1 stop8h 49m
JetBlue
Sat 7/187:17 pm
SAV
- BUF
1 stop4h 56m
JetBlue
Deal found 6/12![JetBlue logo]()
$257
This CheapOair deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/149:09 pm
BUF
- CLT
1 stop14h 20m
Frontier
Tue 7/218:02 pm
CLT
- BUF
1 stop23h 04m
Frontier
Deal found 6/14![Frontier logo]()
$240
This Cheapflightsfares deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:00 am
BUF
- CHS
1 stop6h 15m
JetBlue
Sat 7/185:30 pm
CHS
- BUF
1 stop6h 13m
JetBlue
Deal found 6/14![JetBlue logo]()
$246
This Priceline deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/159:15 am
BUF
- SAV
1 stop8h 40m
JetBlue
Tue 7/216:51 pm
SAV
- BUF
1 stop5h 34m
JetBlue
Deal found 6/14![JetBlue logo]()
$217
This Super.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/219:09 pm
BUF
- CLT
1 stop14h 20m
Frontier
Tue 7/2812:24 pm
CLT
- BUF
1 stop6h 42m
Frontier
Deal found 6/14![Frontier logo]()
$238
This Trip.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/289:09 pm
BUF
- CLT
1 stop14h 20m
Frontier
Tue 8/48:02 pm
CLT
- BUF
1 stop23h 04m
Frontier
Deal found 6/13![Frontier logo]()
$239
This Cheapflightsfares deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2910:25 am
BUF
- CHS
1 stop5h 58m
JetBlue
Tue 8/410:58 am
CHS
- BUF
1 stop7h 27m
JetBlue
Deal found 6/11![JetBlue logo]()
$221
This CheapOair deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:57 pm
BUF
- CLT
1 stop15h 32m
Frontier
Tue 8/48:02 pm
CLT
- BUF
1 stop23h 04m
Frontier
Deal found 6/12![Frontier logo]()
$250
One-way flights from Buffalo to South CarolinaSearch for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
This Flysmarter deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flysmarter is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/410:20 am
BUF
- CHS
1 stop8h 45m
JetBlue
Deal found 6/14![JetBlue logo]()
$90
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:01 am
BUF
- CHS
1 stop4h 41m
Delta
Deal found 6/11![Delta logo]()
$99
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/102:27 pm
BUF
- CHS
1 stop7h 35m
Delta
Deal found 6/10![Delta logo]()
$107
This Frontier deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/57:57 pm
BUF
- CLT
1 stop11h 54m
Frontier
Deal found 6/10![Frontier logo]()
$111
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:30 am
BUF
- CLT
1 stop7h 00m
Southwest
Deal found 6/11![Southwest logo]()
$113
This Cheapflightsfares deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:25 am
BUF
- CHS
1 stop7h 21m
JetBlue
Deal found 6/12![JetBlue logo]()
$113
This Priceline deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/410:25 am
BUF
- SAV
1 stop7h 57m
JetBlue
Deal found 6/14![JetBlue logo]()
$114
This Trip.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/119:09 pm
BUF
- CLT
1 stop14h 20m
Frontier
Deal found 6/14![Frontier logo]()
$114
This JetBlue deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:00 am
BUF
- CHS
1 stop6h 10m
JetBlue
Deal found 6/14![JetBlue logo]()
$114
This Super.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:57 pm
BUF
- CLT
1 stop15h 32m
Frontier
Deal found 6/10![Frontier logo]()
$121
This Trip.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:57 pm
BUF
- CLT
1 stop15h 32m
Frontier
Deal found 6/14![Frontier logo]()
$125
This Trip.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/219:09 pm
BUF
- CLT
1 stop14h 20m
Frontier
Deal found 6/13![Frontier logo]()
$126
Find flight deals from Buffalo to South Carolina
Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated June 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $197 (Delta) |
One-way from | $90 (Flysmarter) |
Popular in | March |
Cheapest in | September |
Average price | $393 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Tue 9/1
6:00 am-12:10 pm
1 stop6h 10m
Charleston
Sat 9/5
11:00 am-7:03 pm
1 stop8h 03m
$202
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Tue 9/22
10:00 am-2:39 pm
1 stop4h 39m
Charleston
Sun 9/27
6:42 pm-11:54 pm
1 stop5h 12m
$232
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sun 9/13
6:16 am-10:45 am
1 stop4h 29m
Charleston
Sat 9/19
6:00 am-10:26 am
1 stop4h 26m
$266
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 7/10
6:01 am-10:07 am
1 stop4h 06m
Charleston
Mon 7/13
6:17 pm-10:51 pm
1 stop4h 34m
$267
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Tue 7/7
6:05 am-10:42 am
1 stop4h 37m
Charleston
Thu 7/9
6:43 pm-11:58 pm
1 stop5h 15m
$267
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 11/20
4:59 pm-9:46 pm
1 stop4h 47m
Charleston
Thu 11/26
10:30 am-3:29 pm
1 stop4h 59m
$293
Quickest round-trip
BuffaloColumbia
BUF - CAE
BUFCAE
Buffalo
Thu 7/9
6:00 am-10:09 am
1 stop4h 09m
Columbia Metropolitan
Tue 7/14
5:00 am-9:03 am
1 stop4h 03m
$297
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Sun 9/13
6:00 am-1:18 pm
1 stop7h 18m
Savannah/Hilton Head
Sat 9/19
2:20 pm-7:01 pm
1 stop4h 41m
$297
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Tue 9/1
6:55 am-1:58 pm
1 stop7h 03m
Charleston
Sat 9/5
6:30 am-2:18 pm
2 stops7h 48m
$309
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 11/20
4:59 pm-9:46 pm
1 stop4h 47m
Charleston
Fri 11/27
6:00 am-12:33 pm
1 stop6h 33m
$319
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Buffalo to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
BUF-CHS
BUF-CLT
BUF-MYR
BUF-SAV
BUF-CAE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to South Carolina
BUF-USSC
BUF-CHS
BUF-CLT
BUF-MYR
BUF-SAV
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, March is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $98). Flying from Buffalo to South Carolina in January is currently the most expensive (average of $236). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Buffalo to South Carolina?
How far ahead should I book a flight from Buffalo to South Carolina?
The price you pay for your flight from Buffalo to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 87 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated June 15, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Buffalo to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Buffalo to South Carolina by cabin class
Find flights from Buffalo to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Buffalo and South Carolina flights
Browse other Buffalo and South Carolina flight options. Last updated on June 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Buffalo to South Carolina flights
Consider these flights traveling from Buffalo to South Carolina.
Top 5 airlines flying from Buffalo to South Carolina
Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$180 | Average$242 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$198 | Average$368 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$199 | Average$353 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$200 | Average$279 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$236 | Average$412 | FlexibilityNo cancel fee | On-time63% |