$131+ Cheap flights from Buffalo (BUF) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/17. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
Dec 5 — Dec 121
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2026.
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2026.
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:58 pm -
1 stop4h 28m
Sat 1/97:21 pm -
1 stop3h 55m
Deal found 11/2![American Airlines logo]()
$261
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/83:00 pm -
2 stops8h 59m
Thu 12/106:00 am -
1 stop7h 17m
Deal found 11/4![United Airlines logo]()
$266
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:00 am -
1 stop4h 13m
Sat 12/510:53 am -
1 stop5h 20m
Deal found 11/2![Delta logo]()
$271
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:00 am -
1 stop4h 13m
Sun 12/66:59 pm -
1 stop5h 05m
Deal found 11/2![Delta logo]()
$281
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am -
1 stop7h 20m
Sat 1/99:46 am -
2 stops9h 46m
Deal found 11/2![United Airlines logo]()
$304
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/25:19 am -
1 stop6h 03m
Wed 12/911:52 am -
1 stop6h 08m
Deal found 11/4![American Airlines logo]()
$308
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:00 am -
1 stop5h 07m
Tue 12/13:40 pm -
1 stop7h 16m
Deal found 11/3![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/812:11 pm -
1 stop5h 52m
Wed 12/166:59 pm -
1 stop5h 05m
Deal found 11/3![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:00 am -
1 stop4h 06m
Fri 11/2710:23 am -
1 stop3h 57m
Deal found 11/1![United Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:03 am -
1 stop6h 15m
Sat 12/126:40 pm -
1 stop4h 14m
Deal found 11/4![American Airlines logo]()
$311
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1810:35 am -
1 stop3h 53m
Tue 12/13:30 pm -
1 stop4h 54m
Deal found 11/3![United Airlines logo]()
$314
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:00 am -
1 stop5h 34m
Tue 12/82:04 pm -
2 stops9h 30m
Deal found 11/3![United Airlines logo]()
$321
Best flights from Buffalo to South CarolinaDiscover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 5, 2026.
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 5, 2026.
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/83:00 pm -
2 stops8h 59m
Thu 12/106:00 am -
1 stop7h 17m
Deal found 11/4![United Airlines logo]()
$266
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/76:00 am -
1 stop5h 18m
Sat 4/107:00 am -
1 stop4h 15m
Deal found 10/31![Delta logo]()
$311
This Southwest deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/28:25 am -
2 stops11h 00m
Wed 12/98:10 am -
2 stops9h 30m
Deal found 11/4![Southwest logo]()
$351
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:56 am -
1 stop4h 31m
Fri 11/275:52 pm -
1 stop5h 47m
Deal found 11/4![American Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/47:03 am -
2 stops8h 10m
Mon 2/82:42 pm -
2 stops8h 17m
Deal found 11/4![United Airlines logo]()
$292
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:10 am -
1 stop4h 31m
Tue 12/86:00 am -
2 stops8h 37m
Deal found 11/3![Delta logo]()
$314
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am -
1 stop7h 20m
Wed 12/910:22 am -
2 stops10h 02m
Deal found 11/2![United Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:00 am -
2 stops12h 03m
Tue 12/86:59 pm -
1 stop5h 05m
Deal found 11/1![Delta logo]()
$314
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/65:20 am -
2 stops7h 40m
Fri 12/117:35 pm -
1 stop4h 15m
Deal found 11/3![Southwest logo]()
$360
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am -
1 stop7h 20m
Sat 1/99:46 am -
2 stops9h 46m
Deal found 11/2![United Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2410:21 am -
2 stops7h 52m
Wed 3/311:24 am -
1 stop5h 40m
Deal found 11/3![Delta logo]()
$314
This Southwest deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/225:50 pm -
1 stop4h 45m
Sun 2/287:10 am -
2 stops7h 35m
Deal found 10/31![Southwest logo]()
$361
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/237:22 am -
1 stop4h 31m
Tue 3/303:34 pm -
1 stop5h 59m
Deal found 10/31![American Airlines logo]()
$419
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:05 am -
2 stops9h 20m
Wed 12/97:30 am -
2 stops7h 45m
Deal found 11/2![Southwest logo]()
$369
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/66:10 am -
1 stop4h 31m
Fri 12/1111:26 am -
1 stop3h 53m
Deal found 11/3![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/266:30 am -
1 stop7h 19m
Tue 3/210:19 am -
2 stops11h 43m
Deal found 11/3![United Airlines logo]()
$366
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:27 pm -
1 stop6h 26m
Tue 11/246:05 pm -
1 stop5h 54m
Deal found 10/31![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/133:05 pm -
1 stop3h 50m
Sun 12/202:55 pm -
2 stops9h 00m
Deal found 11/4![Southwest logo]()
$374
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/36:00 am -
1 stop4h 28m
Sat 4/105:04 pm -
1 stop6h 46m
Deal found 11/3![American Airlines logo]()
$453
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:00 am -
1 stop4h 06m
Thu 11/1912:18 pm -
1 stop8h 18m
Deal found 10/31![United Airlines logo]()
$367
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/84:15 pm -
1 stop6h 10m
Mon 4/128:00 am -
1 stop4h 20m
Deal found 11/3![Southwest logo]()
$383
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1710:35 am -
2 stops7h 04m
Wed 11/183:35 pm -
1 stop4h 34m
Deal found 11/3![United Airlines logo]()
$372
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/167:03 am -
1 stop4h 50m
Fri 11/205:47 pm -
1 stop5h 52m
Deal found 11/1![American Airlines logo]()
$517
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/116:30 am -
1 stop7h 16m
Thu 1/149:45 am -
2 stops9h 47m
Deal found 11/3![United Airlines logo]()
$376
This Southwest deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/121:25 pm -
1 stop9h 10m
Mon 2/151:15 pm -
2 stops10h 00m
Deal found 10/31![Southwest logo]()
$414
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:01 am -
1 stop4h 37m
Tue 1/53:02 pm -
1 stop3h 58m
Deal found 11/4![American Airlines logo]()
$539
This Southwest deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2112:40 pm -
2 stops10h 45m
Mon 1/41:00 pm -
2 stops10h 25m
Deal found 11/4![Southwest logo]()
$442
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:01 am -
1 stop4h 37m
Mon 1/43:02 pm -
1 stop3h 48m
Deal found 11/4![American Airlines logo]()
$539
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/266:00 am -
2 stops9h 14m
Sat 2/2712:50 pm -
2 stops9h 12m
Deal found 11/3![United Airlines logo]()
$412
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:00 am -
2 stops9h 53m
Sat 12/510:27 am -
1 stop6h 30m
Deal found 11/3![United Airlines logo]()
$414
Last-minute flights from Buffalo to South CarolinaDiscover last-minute flight deals from Buffalo to South Carolina. Data last updated November 5, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated November 5, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1810:35 am -
1 stop3h 53m
Tue 12/13:30 pm -
1 stop4h 54m
Deal found 11/3![United Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:00 am -
1 stop5h 07m
Tue 12/13:40 pm -
1 stop7h 16m
Deal found 11/3![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:00 am -
1 stop4h 06m
Fri 11/2710:23 am -
1 stop3h 57m
Deal found 11/1![United Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:00 am -
1 stop4h 13m
Sat 12/510:53 am -
1 stop5h 20m
Deal found 11/2![Delta logo]()
$271
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:00 am -
1 stop4h 13m
Sun 12/66:59 pm -
1 stop5h 05m
Deal found 11/2![Delta logo]()
$281
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/25:19 am -
1 stop6h 03m
Wed 12/911:52 am -
1 stop6h 08m
Deal found 11/4![American Airlines logo]()
$308
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:58 pm -
1 stop4h 28m
Sat 1/97:21 pm -
1 stop3h 55m
Deal found 11/2![American Airlines logo]()
$261
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am -
1 stop7h 20m
Sat 1/99:46 am -
2 stops9h 46m
Deal found 11/2![United Airlines logo]()
$304
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:03 am -
1 stop6h 15m
Sat 12/126:40 pm -
1 stop4h 14m
Deal found 11/4![American Airlines logo]()
$311
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/83:00 pm -
2 stops8h 59m
Thu 12/106:00 am -
1 stop7h 17m
Deal found 11/4![United Airlines logo]()
$266
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/812:11 pm -
1 stop5h 52m
Wed 12/166:59 pm -
1 stop5h 05m
Deal found 11/3![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:00 am -
2 stops7h 33m
Thu 12/106:57 pm -
1 stop5h 07m
Deal found 11/4![Delta logo]()
$314
One-way flights from Buffalo to South CarolinaSearch for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated November 5, 2026.
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated November 5, 2026.
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2312:16 pm -
1 stop4h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Delta logo]()
$131
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:00 am -
1 stop4h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![United Airlines logo]()
$141
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/611:32 am -
1 stop4h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![American Airlines logo]()
$146
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/56:07 pm -
1 stop5h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![American Airlines logo]()
$155
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:10 am -
1 stop4h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Delta logo]()
$155
This Southwest deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/191:40 pm -
1 stop9h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![Southwest logo]()
$160
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1612:45 pm -
2 stops6h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Southwest logo]()
$160
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:44 pm -
1 stop4h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![American Airlines logo]()
$165
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:00 am -
1 stop5h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![American Airlines logo]()
$170
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:12 am -
1 stop4h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![American Airlines logo]()
$170
This Southwest deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/195:40 pm -
1 stop4h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![Southwest logo]()
$171
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/316:01 am -
1 stop4h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![American Airlines logo]()
$171
Find flight deals from Buffalo to South Carolina
Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated November 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $261 (Delta) |
One-way from | $131 (Delta) |
Popular in | March |
Cheapest in | October |
Average price | $372 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 5, 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloCharleston
BUF Buffalo - CHS Charleston
BUFCHS
Buffalo
Thu 12/17
6:00 am-10:20 am
1 stop4h 20m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$131
BuffaloCharleston
BUF Buffalo - CHS Charleston
BUFCHS
Buffalo
Fri 12/18
6:00 am-12:59 pm
1 stop6h 59m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$131
BuffaloCharleston
BUF Buffalo - CHS Charleston
BUFCHS
Buffalo
Thu 12/3
4:50 pm-10:22 pm
1 stop5h 32m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$131
BuffaloCharleston
BUF Buffalo - CHS Charleston
BUFCHS
Buffalo
Tue 12/1
12:06 pm-6:02 pm
1 stop5h 56m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$131
Quickest round-trip
BuffaloCharleston
BUF Buffalo - CHS Charleston
BUFCHS
Buffalo
Mon 11/30
6:00 am-10:13 am
1 stop4h 13m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$141
BuffaloCharleston
BUF Buffalo - CHS Charleston
BUFCHS
Buffalo
Sun 12/6
11:32 am-4:20 pm
1 stop4h 48m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$146
BuffaloGreenville
BUF Buffalo - GSP Greenville
BUFGSP
Buffalo
Tue 1/5
6:07 pm-11:33 pm
1 stop5h 26m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$155
BuffaloGreenville
BUF Buffalo - GSP Greenville
BUFGSP
Buffalo
Mon 1/4
6:00 am-11:05 am
1 stop5h 05m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$155
BuffaloMyrtle Beach
BUF Buffalo - MYR Myrtle Beach Intl
BUFMYR
Buffalo
Wed 12/16
6:10 am-10:41 am
1 stop4h 31m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$155
BuffaloMyrtle Beach
BUF Buffalo - MYR Myrtle Beach Intl
BUFMYR
Buffalo
Tue 12/1
6:05 am-10:41 am
1 stop4h 36m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$155
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Buffalo to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
BUF-CHS
BUF-MYR
BUF-GSP
BUF-CAE
BUF-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to South Carolina
BUF-USSC
BUF-CHS
BUF-MYR
BUF-GSP
BUF-CAE
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, January is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $314). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $437). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Buffalo to South Carolina?
Airfare is below average for this route at the moment.
Buffalo to South Carolina flights typically cost between $280 and $504 in February.The cheapest round-trip price found within the last 5 days was $261 on Delta (Feb 26-Mar 2).
How far ahead should I book a flight from Buffalo to South Carolina?
The price you pay for your flight from Buffalo to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 36 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 5, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Food
7.0
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Food
7.0
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Food
7.0
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Food
7.0
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Related info for your journey
Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Buffalo to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Buffalo and South Carolina flights
Browse other Buffalo and South Carolina flight options. Last updated on November 5, 2026.
Popular flight searches
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Buffalo to South Carolina flights
Consider these flights traveling from Buffalo to South Carolina.
Top 4 airlines flying from Buffalo to South Carolina
Discover the top 4 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$188 | Average$279 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$196 | Average$369 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$200 | Average$385 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$266 | Average$445 | FlexibilityNo cancel fee | On-time63% |