$106+ Cheap flights from Buffalo (BUF) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
Aug 31 — Sep 71
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to South Carolina with Cheapflights
1. Tell us where you want to go
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to South Carolina
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Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 1, 2026.
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 1, 2026.
This Frontier deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/189:29 pm
BUF
- CLT
1 stop10h 32m
Frontier
Sat 8/229:52 pm
CLT
- BUF
1 stop11h 31m
Frontier
Deal found 7/27![Frontier logo]()
$200
This CheapOair deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:54 pm
BUF
- CLT
1 stop13h 07m
Frontier
Wed 9/28:56 am
CLT
- BUF
1 stop9h 13m
Frontier
Deal found 7/29![Frontier logo]()
$210
This Frontier deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/209:29 pm
BUF
- CLT
1 stop10h 32m
Frontier
Sat 8/229:52 pm
CLT
- BUF
1 stop11h 31m
Frontier
Deal found 7/29![Frontier logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:36 am
BUF
- CHS
2 stops21h 02m
Multiple Airlines
Tue 9/13:13 pm
CHS
- BUF
1 stop26h 56m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$219
This Frontier deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/259:29 pm
BUF
- CLT
1 stop10h 32m
Frontier
Mon 9/79:52 pm
CLT
- BUF
1 stop11h 31m
Frontier
Deal found 7/29![Frontier logo]()
$225
This Frontier deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/209:29 pm
BUF
- CLT
1 stop10h 32m
Frontier
Mon 8/249:52 pm
CLT
- BUF
1 stop11h 31m
Frontier
Deal found 7/30![Frontier logo]()
$228
This CheapOair deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:54 pm
BUF
- CLT
1 stop22h 04m
Frontier
Tue 8/259:52 pm
CLT
- BUF
1 stop20h 17m
Frontier
Deal found 7/29![Frontier logo]()
$230
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:21 am
BUF
- CLT
Nonstop1h 59m
American Airlines
Sun 9/69:20 am
CLT
- BUF
1 stop7h 50m
American Airlines
Deal found 8/1![American Airlines logo]()
$233
This CheapOair deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/279:29 pm
BUF
- CLT
1 stop16h 21m
Frontier
Tue 9/19:52 pm
CLT
- BUF
1 stop20h 17m
Frontier
Deal found 7/27![Frontier logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:29 pm
BUF
- CHS
1 stop11h 39m
Multiple Airlines
Sat 9/58:56 pm
CHS
- BUF
2 stops37h 33m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2211:36 am
BUF
- CHS
2 stops21h 02m
Multiple Airlines
Tue 9/13:13 pm
CHS
- BUF
1 stop26h 56m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/259:29 pm
BUF
- CHS
1 stop11h 39m
Multiple Airlines
Sat 8/298:56 pm
CHS
- BUF
2 stops37h 33m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$239
Best flights from Buffalo to South CarolinaDiscover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 1, 2026.
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 1, 2026.
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:59 pm
BUF
- CHS
1 stop5h 00m
Delta
Mon 10/56:40 am
CHS
- BUF
1 stop4h 30m
Delta
Deal found 7/27![Delta logo]()
$249
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:30 am
BUF
- CHS
1 stop4h 40m
United Airlines
Sat 9/510:14 am
CHS
- BUF
1 stop4h 04m
United Airlines
Deal found 7/29![United Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:00 am
BUF
- CHS
1 stop6h 35m
Southwest
Wed 9/27:35 am
CHS
- BUF
2 stops10h 10m
Southwest
Deal found 7/29![Southwest logo]()
$254
This JetBlue deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:10 pm
BUF
- SAV
1 stop8h 47m
JetBlue
Thu 10/158:45 am
SAV
- BUF
1 stop5h 30m
JetBlue
Deal found 7/28![JetBlue logo]()
$273
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2311:08 am
BUF
- CHS
1 stop5h 45m
American Airlines
Mon 10/267:05 pm
CHS
- BUF
1 stop3h 45m
American Airlines
Deal found 7/31![American Airlines logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1510:02 pm
BUF
- MYR
1 stop10h 53m
Multiple Airlines
Sat 8/224:21 pm
MYR
- BUF
2 stops18h 08m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$409
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:00 am
BUF
- CHS
1 stop5h 10m
Delta
Tue 11/175:50 pm
CHS
- BUF
1 stop6h 09m
Delta
Deal found 7/27![Delta logo]()
$249
This JetBlue deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:00 am
BUF
- SAV
1 stop7h 45m
JetBlue
Sat 10/318:45 am
SAV
- BUF
1 stop4h 52m
JetBlue
Deal found 7/28![JetBlue logo]()
$275
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:15 am
BUF
- CHS
1 stop3h 55m
Southwest
Sat 10/246:15 am
CHS
- BUF
2 stops8h 20m
Southwest
Deal found 7/28![Southwest logo]()
$279
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:59 pm
BUF
- CHS
1 stop5h 00m
Delta
Mon 9/286:44 pm
CHS
- BUF
1 stop5h 09m
Delta
Deal found 7/30![Delta logo]()
$256
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:30 am
BUF
- CAE
2 stops10h 26m
United Airlines
Mon 10/267:54 pm
CAE
- BUF
1 stop3h 52m
United Airlines
Deal found 7/30![United Airlines logo]()
$300
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2911:50 am
BUF
- GSP
1 stop4h 20m
American Airlines
Wed 9/210:12 am
GSP
- BUF
1 stop5h 47m
American Airlines
Deal found 7/27![American Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/243:53 pm
BUF
- CHS
1 stop5h 27m
Delta
Thu 8/273:50 pm
CHS
- BUF
1 stop7h 39m
Delta
Deal found 7/31![Delta logo]()
$263
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/810:30 am
BUF
- GSP
1 stop6h 44m
United Airlines
Tue 9/156:30 am
GSP
- BUF
2 stops7h 48m
United Airlines
Deal found 7/27![United Airlines logo]()
$314
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/912:00 pm
BUF
- GSP
2 stops9h 00m
Southwest
Tue 9/158:15 am
GSP
- BUF
1 stop6h 05m
Southwest
Deal found 7/30![Southwest logo]()
$314
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:00 am
BUF
- CHS
1 stop6h 54m
Delta
Fri 12/2512:15 pm
CHS
- BUF
1 stop5h 34m
Delta
Deal found 7/28![Delta logo]()
$269
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am
BUF
- GSP
2 stops7h 33m
United Airlines
Mon 11/97:43 pm
GSP
- BUF
1 stop4h 03m
United Airlines
Deal found 7/28![United Airlines logo]()
$314
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/228:55 am
BUF
- MYR
1 stop4h 55m
Southwest
Tue 9/298:15 am
MYR
- BUF
2 stops7h 00m
Southwest
Deal found 7/30![Southwest logo]()
$314
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:00 am
BUF
- CAE
1 stop4h 50m
American Airlines
Sat 8/1510:15 am
CAE
- BUF
1 stop6h 09m
American Airlines
Deal found 7/27![American Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/153:00 pm
BUF
- MYR
1 stop4h 15m
Southwest
Thu 9/171:55 pm
MYR
- BUF
2 stops8h 00m
Southwest
Deal found 7/27![Southwest logo]()
$314
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:55 am
BUF
- HHH
1 stop7h 08m
United Airlines
Mon 8/242:58 pm
HHH
- BUF
1 stop6h 09m
United Airlines
Deal found 7/27![United Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:20 pm
BUF
- CAE
1 stop6h 27m
Delta
Sat 11/146:00 am
CAE
- BUF
1 stop5h 23m
Delta
Deal found 7/31![Delta logo]()
$295
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:30 am
BUF
- CAE
2 stops10h 58m
United Airlines
Wed 9/27:54 pm
CAE
- BUF
1 stop3h 50m
United Airlines
Deal found 7/29![United Airlines logo]()
$320
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:40 am
BUF
- SAV
2 stops9h 55m
Southwest
Sat 8/2912:50 pm
SAV
- BUF
2 stops8h 15m
Southwest
Deal found 7/27![Southwest logo]()
$328
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:23 pm
BUF
- CAE
2 stops6h 37m
American Airlines
Wed 9/165:20 am
CAE
- BUF
1 stop5h 58m
American Airlines
Deal found 7/29![American Airlines logo]()
$407
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:01 am
BUF
- SAV
1 stop5h 24m
Delta
Sun 9/66:37 pm
SAV
- BUF
1 stop5h 22m
Delta
Deal found 7/31![Delta logo]()
$307
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am
BUF
- CHS
2 stops8h 28m
United Airlines
Sat 11/1412:30 pm
CHS
- BUF
1 stop8h 21m
United Airlines
Deal found 7/27![United Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:05 am
BUF
- GSP
1 stop6h 45m
Delta
Tue 9/158:05 am
GSP
- BUF
1 stop6h 46m
Delta
Deal found 7/27![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/212:35 pm
BUF
- MYR
2 stops9h 05m
Southwest
Tue 10/67:50 am
MYR
- BUF
2 stops10h 30m
Southwest
Deal found 7/29![Southwest logo]()
$345
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:30 am
BUF
- CHS
2 stops8h 30m
United Airlines
Wed 10/289:55 am
CHS
- BUF
2 stops13h 04m
United Airlines
Deal found 7/27![United Airlines logo]()
$339
Last-minute flights from Buffalo to South CarolinaDiscover last-minute flight deals from Buffalo to South Carolina. Data last updated August 1, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated August 1, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/189:29 pm
BUF
- CLT
1 stop10h 32m
Frontier
Sat 8/229:52 pm
CLT
- BUF
1 stop11h 31m
Frontier
Deal found 7/27![Frontier logo]()
$200
This CheapOair deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/189:29 pm
BUF
- CLT
1 stop19h 29m
Frontier
Thu 8/202:45 pm
CLT
- BUF
1 stop27h 24m
Frontier
Deal found 7/30![Frontier logo]()
$244
This CheapOair deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:54 pm
BUF
- CLT
1 stop22h 04m
Frontier
Tue 8/259:52 pm
CLT
- BUF
1 stop20h 17m
Frontier
Deal found 7/29![Frontier logo]()
$230
This Frontier deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/209:29 pm
BUF
- CLT
1 stop10h 32m
Frontier
Sat 8/229:52 pm
CLT
- BUF
1 stop11h 31m
Frontier
Deal found 7/29![Frontier logo]()
$214
This Frontier deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/209:29 pm
BUF
- CLT
1 stop10h 32m
Frontier
Mon 8/249:52 pm
CLT
- BUF
1 stop11h 31m
Frontier
Deal found 7/30![Frontier logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2211:36 am
BUF
- CHS
2 stops21h 02m
Multiple Airlines
Tue 9/13:13 pm
CHS
- BUF
1 stop26h 56m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:36 am
BUF
- CHS
2 stops21h 02m
Multiple Airlines
Tue 9/13:13 pm
CHS
- BUF
1 stop26h 56m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$219
This Frontier deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/259:29 pm
BUF
- CLT
1 stop10h 32m
Frontier
Mon 9/79:52 pm
CLT
- BUF
1 stop11h 31m
Frontier
Deal found 7/29![Frontier logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/259:29 pm
BUF
- CHS
1 stop11h 39m
Multiple Airlines
Sat 8/298:56 pm
CHS
- BUF
2 stops37h 33m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$239
This CheapOair deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:54 pm
BUF
- CLT
1 stop13h 07m
Frontier
Wed 9/28:56 am
CLT
- BUF
1 stop9h 13m
Frontier
Deal found 7/29![Frontier logo]()
$210
This CheapOair deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/279:29 pm
BUF
- CLT
1 stop16h 21m
Frontier
Tue 9/19:52 pm
CLT
- BUF
1 stop20h 17m
Frontier
Deal found 7/27![Frontier logo]()
$235
This CheapOair deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:54 pm
BUF
- CLT
1 stop13h 07m
Frontier
Sat 8/299:52 pm
CLT
- BUF
1 stop11h 31m
Frontier
Deal found 7/30![Frontier logo]()
$240
One-way flights from Buffalo to South CarolinaSearch for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 1, 2026.
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 1, 2026.
This Frontier deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/259:29 pm
BUF
- CLT
1 stop10h 32m
Frontier
Deal found 7/29![Frontier logo]()
$106
This Justfly.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:29 pm
BUF
- CLT
1 stop10h 32m
Frontier
Deal found 7/30![Frontier logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1012:49 pm
BUF
- GSP
1 stop7h 00m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/281:13 pm
BUF
- CLT
2 stops24h 38m
Frontier
Deal found 7/29![Frontier logo]()
$119
This Frontier deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/279:29 pm
BUF
- CLT
1 stop10h 32m
Frontier
Deal found 7/30![Frontier logo]()
$120
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:54 pm
BUF
- CLT
1 stop13h 07m
Frontier
Deal found 7/30![Frontier logo]()
$122
This Super.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1510:02 pm
BUF
- CLT
1 stop9h 49m
Frontier
Deal found 7/29![Frontier logo]()
$125
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:59 pm
BUF
- CHS
1 stop4h 01m
American Airlines
Deal found 7/27![American Airlines logo]()
$125
This JetBlue deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/212:10 pm
BUF
- CHS
1 stop7h 15m
JetBlue
Deal found 7/30![JetBlue logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/309:29 pm
BUF
- CLT
2 stops22h 42m
Frontier
Deal found 7/30![Frontier logo]()
$128
This Trip.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2811:36 am
BUF
- MYR
2 stops24h 07m
Frontier
Deal found 7/30![Frontier logo]()
$129
This Frontier deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/1312:49 pm
BUF
- CLT
1 stop5h 32m
Frontier
Deal found 7/29![Frontier logo]()
$130
Find flight deals from Buffalo to South Carolina
Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated August 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $200 (Frontier) |
One-way from | $106 (Frontier) |
Popular in | March |
Cheapest in | October |
Average price | $354 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 1, 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 10/2
6:59 pm-11:59 pm
1 stop5h 00m
Charleston
Mon 10/5
6:40 am-11:10 am
1 stop4h 30m
$249
Quickest round-trip
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Tue 9/1
10:30 am-3:10 pm
1 stop4h 40m
Charleston
Sat 9/5
10:14 am-2:18 pm
1 stop4h 04m
$249
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sat 11/14
6:00 am-11:10 am
1 stop5h 10m
Charleston
Tue 11/17
5:50 pm-11:59 pm
1 stop6h 09m
$249
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Wed 8/26
6:00 am-12:35 pm
1 stop6h 35m
Charleston
Wed 9/2
7:35 am-5:45 pm
2 stops10h 10m
$254
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 9/25
6:59 pm-11:59 pm
1 stop5h 00m
Charleston
Mon 9/28
6:44 pm-11:53 pm
1 stop5h 09m
$256
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Mon 8/24
3:53 pm-9:20 pm
1 stop5h 27m
Charleston
Thu 8/27
3:50 pm-11:29 pm
1 stop7h 39m
$263
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 12/18
6:00 am-12:54 pm
1 stop6h 54m
Charleston
Fri 12/25
12:15 pm-5:49 pm
1 stop5h 34m
$269
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Tue 10/13
3:10 pm-11:57 pm
1 stop8h 47m
Savannah/Hilton Head
Thu 10/15
8:45 am-2:15 pm
1 stop5h 30m
$273
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Tue 10/27
7:00 am-2:45 pm
1 stop7h 45m
Savannah/Hilton Head
Sat 10/31
8:45 am-1:37 pm
1 stop4h 52m
$275
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Wed 10/21
6:15 am-10:10 am
1 stop3h 55m
Charleston
Sat 10/24
6:15 am-2:35 pm
2 stops8h 20m
$279
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Buffalo to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
BUF-CLT
BUF-GSP
BUF-CHS
BUF-MYR
BUF-SAV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to South Carolina
BUF-USSC
BUF-CLT
BUF-GSP
BUF-CHS
BUF-MYR
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, September is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $281). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $433). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Buffalo to South Carolina?
Airfare is below average for this route at the moment.
Buffalo to South Carolina flights typically cost between $266 and $346 in August.The cheapest round-trip price found within the last 5 days was $219 on Multiple Airlines (Aug 24-Sep 1).
How far ahead should I book a flight from Buffalo to South Carolina?
The price you pay for your flight from Buffalo to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 85 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 1, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Buffalo to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Buffalo to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Buffalo and South Carolina flights
Browse other Buffalo and South Carolina flight options. Last updated on August 1, 2026.
Popular flight searches
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Buffalo to South Carolina flights
Consider these flights traveling from Buffalo to South Carolina.
Top 5 airlines flying from Buffalo to South Carolina
Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$180 | Average$250 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$198 | Average$377 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$199 | Average$358 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$200 | Average$279 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$236 | Average$421 | FlexibilityNo cancel fee | On-time63% |