$90+ Cheap flights from South Carolina to Buffalo (BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BUF
Jun 5 — Jun 121
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Buffalo with Cheapflights
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Cheapest flights from South Carolina to BuffaloExplore the most affordable flight options available from South Carolina to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 6, 2026.
Explore the most affordable flight options available from South Carolina to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:58 pm
CLT
- BUF
1 stop23h 14m
Frontier
Tue 6/1611:50 am
BUF
- CLT
2 stops21h 26m
Frontier
Deal found 5/1![Frontier logo]()
$224
This Trip.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:58 pm
CLT
- BUF
1 stop23h 01m
Frontier
Fri 5/227:52 pm
BUF
- CLT
1 stop16h 13m
Frontier
Deal found 5/1![Frontier logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/126:33 pm
CLT
- BUF
2 stops40h 07m
Frontier
Tue 6/239:02 pm
BUF
- CLT
1 stop19h 51m
Frontier
Deal found 5/2![Frontier logo]()
$251
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:14 pm
SAV
- BUF
1 stop6h 24m
Delta
Sun 6/146:00 am
BUF
- SAV
1 stop7h 12m
Delta
Deal found 5/5![Delta logo]()
$251
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/283:14 pm
SAV
- BUF
2 stops8h 45m
United Airlines
Mon 6/17:00 pm
BUF
- SAV
1 stop4h 52m
United Airlines
Deal found 5/1![United Airlines logo]()
$256
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:38 pm
CHS
- BUF
1 stop5h 21m
Delta
Tue 6/24:55 pm
BUF
- CHS
1 stop4h 57m
Delta
Deal found 5/2![Delta logo]()
$257
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:45 pm
CAE
- BUF
1 stop4h 14m
United Airlines
Wed 8/127:00 am
BUF
- CAE
1 stop7h 12m
United Airlines
Deal found 5/2![United Airlines logo]()
$261
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2711:31 am
CHS
- BUF
2 stops11h 00m
United Airlines
Sat 5/306:09 am
BUF
- CHS
1 stop4h 07m
United Airlines
Deal found 5/5![United Airlines logo]()
$262
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:00 am
CHS
- BUF
1 stop6h 11m
American Airlines
Tue 5/267:31 pm
BUF
- CHS
1 stop4h 17m
American Airlines
Deal found 5/5![American Airlines logo]()
$264
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/17:45 pm
CAE
- BUF
1 stop4h 14m
United Airlines
Wed 8/56:00 am
BUF
- CAE
2 stops8h 16m
United Airlines
Deal found 5/3![United Airlines logo]()
$266
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:07 pm
GSP
- BUF
1 stop4h 51m
Delta
Wed 8/194:13 pm
BUF
- GSP
1 stop4h 19m
Delta
Deal found 5/4![Delta logo]()
$271
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/191:19 pm
CHS
- BUF
1 stop7h 42m
United Airlines
Wed 5/206:04 am
BUF
- CHS
1 stop4h 09m
United Airlines
Deal found 5/4![United Airlines logo]()
$272
Best flights from South Carolina to BuffaloDiscover carefully curated flight deals from South Carolina to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 6, 2026.
Discover carefully curated flight deals from South Carolina to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 6, 2026.
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:10 pm
SAV
- BUF
1 stop5h 49m
Delta
Sun 6/145:12 pm
BUF
- SAV
1 stop6h 55m
Delta
Deal found 5/2![Delta logo]()
$251
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/283:14 pm
SAV
- BUF
2 stops8h 45m
United Airlines
Mon 6/17:00 pm
BUF
- SAV
1 stop4h 52m
United Airlines
Deal found 5/1![United Airlines logo]()
$256
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Wed 5/205:30 am
BUF
- SAV
1 stop5h 19m
American Airlines
Deal found 5/1![American Airlines logo]()
$283
This JetBlue deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/910:42 am
SAV
- BUF
1 stop8h 23m
JetBlue
Wed 6/109:54 am
BUF
- SAV
1 stop8h 24m
JetBlue
Deal found 5/4![JetBlue logo]()
$313
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:35 pm
CHS
- BUF
1 stop4h 35m
Southwest
Sun 6/216:10 am
BUF
- CHS
1 stop4h 00m
Southwest
Deal found 5/5![Southwest logo]()
$318
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/15:31 pm
SAV
- BUF
1 stop6h 11m
Delta
Mon 8/316:00 am
BUF
- SAV
1 stop5h 20m
Delta
Deal found 5/4![Delta logo]()
$251
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:47 pm
CHS
- BUF
1 stop4h 12m
United Airlines
Sat 5/306:09 am
BUF
- CHS
1 stop4h 07m
United Airlines
Deal found 5/5![United Airlines logo]()
$257
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/56:24 pm
CHS
- BUF
1 stop5h 35m
Delta
Sat 7/116:10 am
BUF
- CHS
1 stop4h 29m
Delta
Deal found 5/4![Delta logo]()
$257
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/276:01 pm
CAE
- BUF
1 stop4h 01m
American Airlines
Wed 7/16:21 pm
BUF
- CAE
1 stop4h 49m
American Airlines
Deal found 4/30![American Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/42:25 pm
CHS
- BUF
1 stop4h 18m
Delta
Mon 9/77:40 pm
BUF
- CHS
1 stop4h 17m
Delta
Deal found 5/1![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/167:05 pm
MYR
- BUF
1 stop3h 35m
Southwest
Tue 6/2312:50 pm
BUF
- MYR
1 stop5h 35m
Southwest
Deal found 5/3![Southwest logo]()
$319
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:45 pm
CAE
- BUF
1 stop4h 14m
United Airlines
Wed 8/196:00 am
BUF
- CAE
2 stops8h 10m
United Airlines
Deal found 5/5![United Airlines logo]()
$301
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:55 pm
CHS
- BUF
1 stop4h 37m
Delta
Sun 6/76:00 am
BUF
- CHS
1 stop4h 18m
Delta
Deal found 5/1![Delta logo]()
$257
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1111:40 am
HHH
- BUF
2 stops9h 43m
American Airlines
Sun 6/146:26 am
BUF
- HHH
1 stop6h 00m
American Airlines
Deal found 5/4![American Airlines logo]()
$316
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/172:10 pm
MYR
- BUF
2 stops7h 15m
Southwest
Tue 6/2312:50 pm
BUF
- MYR
2 stops8h 55m
Southwest
Deal found 5/4![Southwest logo]()
$329
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:16 pm
GSP
- BUF
1 stop6h 43m
Delta
Wed 6/246:00 am
BUF
- GSP
1 stop6h 18m
Delta
Deal found 5/2![Delta logo]()
$271
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/812:55 pm
GSP
- BUF
2 stops9h 40m
Southwest
Wed 6/104:25 pm
BUF
- GSP
1 stop3h 50m
Southwest
Deal found 5/1![Southwest logo]()
$330
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:36 pm
MYR
- BUF
1 stop4h 26m
American Airlines
Tue 5/2611:03 am
BUF
- MYR
2 stops6h 36m
American Airlines
Deal found 5/2![American Airlines logo]()
$331
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:45 pm
CAE
- BUF
1 stop4h 14m
United Airlines
Sat 5/307:00 am
BUF
- CAE
1 stop6h 43m
United Airlines
Deal found 4/30![United Airlines logo]()
$341
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:53 pm
SAV
- BUF
1 stop5h 06m
Delta
Sat 6/61:29 pm
BUF
- SAV
1 stop5h 49m
Delta
Deal found 5/2![Delta logo]()
$275
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:45 pm
MYR
- BUF
1 stop6h 00m
Southwest
Mon 6/84:10 pm
BUF
- MYR
1 stop6h 35m
Southwest
Deal found 5/4![Southwest logo]()
$333
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2410:20 am
CAE
- BUF
1 stop6h 27m
United Airlines
Tue 10/277:00 am
BUF
- CAE
1 stop7h 12m
United Airlines
Deal found 5/4![United Airlines logo]()
$341
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:55 pm
SAV
- BUF
2 stops8h 15m
Southwest
Mon 6/84:10 pm
BUF
- SAV
1 stop4h 20m
Southwest
Deal found 5/4![Southwest logo]()
$336
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2811:31 am
CHS
- BUF
2 stops12h 28m
United Airlines
Sat 5/306:09 am
BUF
- CHS
1 stop4h 07m
United Airlines
Deal found 5/1![United Airlines logo]()
$342
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/177:06 am
CHS
- BUF
1 stop4h 16m
Delta
Sun 7/196:05 am
BUF
- CHS
1 stop4h 37m
Delta
Deal found 5/2![Delta logo]()
$308
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:50 am
CLT
- BUF
2 stops8h 25m
Southwest
Wed 8/1912:35 pm
BUF
- CLT
2 stops8h 50m
Southwest
Deal found 5/2![Southwest logo]()
$341
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2811:31 am
CHS
- BUF
2 stops12h 28m
United Airlines
Wed 6/37:00 pm
BUF
- CHS
1 stop4h 52m
United Airlines
Deal found 5/2![United Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2012:54 pm
AGS
- BUF
1 stop5h 44m
American Airlines
Wed 5/277:31 pm
BUF
- AGS
1 stop4h 28m
American Airlines
Deal found 5/2![American Airlines logo]()
$429
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:38 pm
CHS
- BUF
1 stop5h 21m
Delta
Thu 6/47:39 pm
BUF
- CHS
1 stop4h 20m
Delta
Deal found 5/2![Delta logo]()
$308
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/14:02 pm
CHS
- BUF
1 stop7h 16m
United Airlines
Wed 9/26:00 am
BUF
- CHS
2 stops8h 25m
United Airlines
Deal found 5/2![United Airlines logo]()
$342
Last-minute flights from South Carolina to BuffaloDiscover last-minute flight deals from South Carolina to Buffalo. Data last updated May 6, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Buffalo. Data last updated May 6, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/191:19 pm
CHS
- BUF
1 stop7h 42m
United Airlines
Wed 5/206:04 am
BUF
- CHS
1 stop4h 09m
United Airlines
Deal found 5/4![United Airlines logo]()
$272
This Trip.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:58 pm
CLT
- BUF
1 stop23h 01m
Frontier
Fri 5/227:52 pm
BUF
- CLT
1 stop16h 13m
Frontier
Deal found 5/1![Frontier logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/233:44 pm
CHS
- BUF
2 stops28h 20m
Multiple Airlines
Tue 5/267:52 pm
BUF
- CHS
1 stop13h 46m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$274
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:00 am
CHS
- BUF
1 stop6h 11m
American Airlines
Tue 5/267:31 pm
BUF
- CHS
1 stop4h 17m
American Airlines
Deal found 5/5![American Airlines logo]()
$264
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2711:31 am
CHS
- BUF
2 stops11h 00m
United Airlines
Sat 5/306:09 am
BUF
- CHS
1 stop4h 07m
United Airlines
Deal found 5/5![United Airlines logo]()
$262
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/283:14 pm
SAV
- BUF
2 stops8h 45m
United Airlines
Mon 6/17:00 pm
BUF
- SAV
1 stop4h 52m
United Airlines
Deal found 5/1![United Airlines logo]()
$256
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:38 pm
CHS
- BUF
1 stop5h 21m
Delta
Tue 6/24:55 pm
BUF
- CHS
1 stop4h 57m
Delta
Deal found 5/2![Delta logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:58 pm
CLT
- BUF
1 stop23h 14m
Frontier
Tue 6/1611:50 am
BUF
- CLT
2 stops21h 26m
Frontier
Deal found 5/1![Frontier logo]()
$224
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/910:55 am
GSP
- BUF
1 stop6h 35m
Delta
Wed 6/1010:20 am
BUF
- GSP
1 stop7h 07m
Delta
Deal found 5/4![Delta logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1012:29 pm
CLT
- BUF
1 stop6h 43m
Frontier
Wed 6/172:50 pm
BUF
- CLT
2 stops21h 24m
Frontier
Deal found 5/4![Frontier logo]()
$275
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:14 pm
SAV
- BUF
1 stop6h 24m
Delta
Sun 6/146:00 am
BUF
- SAV
1 stop7h 12m
Delta
Deal found 5/5![Delta logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/126:33 pm
CLT
- BUF
2 stops40h 07m
Frontier
Tue 6/239:02 pm
BUF
- CLT
1 stop19h 51m
Frontier
Deal found 5/2![Frontier logo]()
$251
One-way flights from South Carolina to BuffaloSearch for one-way flight options from South Carolina to Buffalo. Find affordable one-way fares based on user searches. Data last updated May 6, 2026.
Search for one-way flight options from South Carolina to Buffalo. Find affordable one-way fares based on user searches. Data last updated May 6, 2026.
This Frontier deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:00 pm
CLT
- BUF
1 stop5h 59m
Frontier
Deal found 5/2![Frontier logo]()
$90
This Frontier deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3012:29 pm
CLT
- BUF
1 stop6h 43m
Frontier
Deal found 5/1![Frontier logo]()
$95
This Frontier deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1612:29 pm
CLT
- BUF
1 stop6h 43m
Frontier
Deal found 5/2![Frontier logo]()
$96
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/113:55 pm
CHS
- BUF
2 stops45h 58m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:50 pm
CLT
- BUF
2 stops20h 04m
Frontier
Deal found 5/2![Frontier logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/258:33 pm
CHS
- BUF
2 stops39h 01m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$112
This Frontier deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/2812:29 pm
CLT
- BUF
1 stop6h 43m
Frontier
Deal found 5/4![Frontier logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:10 am
CLT
- BUF
2 stops25h 31m
Frontier
Deal found 5/5![Frontier logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/110:20 pm
CLT
- BUF
2 stops39h 35m
Frontier
Deal found 5/2![Frontier logo]()
$120
This Expedia deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/288:02 pm
CLT
- BUF
1 stop23h 04m
Frontier
Deal found 5/2![Frontier logo]()
$121
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:41 pm
CLT
- BUF
2 stops40h 00m
Frontier
Deal found 5/1![Frontier logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/271:22 pm
CLT
- BUF
2 stops21h 18m
Frontier
Deal found 5/2![Frontier logo]()
$124
Find flight deals from South Carolina to Buffalo
Keep the following information in mind while searching for South Carolina to Buffalo flight deals. Data was last updated May 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $224 (Kiwi.com) |
One-way from | $90 (Frontier) |
Popular in | March |
Cheapest in | January |
Average price | $380 |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 6, 2026.
Use the filters below to find and compare flights from South Carolina to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
SavannahBuffalo
SAV - BUF
SAVBUF
Savannah/Hilton Head
Thu 6/11
6:10 pm-11:59 pm
1 stop5h 49m
Buffalo
Sun 6/14
5:12 pm-12:07 am
1 stop6h 55m
$251
SavannahBuffalo
SAV - BUF
SAVBUF
Savannah/Hilton Head
Sat 8/1
5:31 pm-11:42 pm
1 stop6h 11m
Buffalo
Mon 8/31
6:00 am-11:20 am
1 stop5h 20m
$251
SavannahBuffalo
SAV - BUF
SAVBUF
Savannah/Hilton Head
Thu 5/28
3:14 pm-11:59 pm
2 stops8h 45m
Buffalo
Mon 6/1
7:00 pm-11:52 pm
1 stop4h 52m
$256
Quickest round-trip
CharlestonBuffalo
CHS - BUF
CHSBUF
Charleston
Wed 5/27
7:47 pm-11:59 pm
1 stop4h 12m
Buffalo
Sat 5/30
6:09 am-10:16 am
1 stop4h 07m
$257
CharlestonBuffalo
CHS - BUF
CHSBUF
Charleston
Sun 7/5
6:24 pm-11:59 pm
1 stop5h 35m
Buffalo
Sat 7/11
6:10 am-10:39 am
1 stop4h 29m
$257
CharlestonBuffalo
CHS - BUF
CHSBUF
Charleston
Fri 9/4
2:25 pm-6:43 pm
1 stop4h 18m
Buffalo
Mon 9/7
7:40 pm-11:57 pm
1 stop4h 17m
$257
CharlestonBuffalo
CHS - BUF
CHSBUF
Charleston
Thu 6/4
6:55 pm-11:32 pm
1 stop4h 37m
Buffalo
Sun 6/7
6:00 am-10:18 am
1 stop4h 18m
$257
GreenvilleBuffalo
GSP - BUF
GSPBUF
Greenville
Wed 6/17
5:16 pm-11:59 pm
1 stop6h 43m
Buffalo
Wed 6/24
6:00 am-12:18 pm
1 stop6h 18m
$271
SavannahBuffalo
SAV - BUF
SAVBUF
Savannah/Hilton Head
Tue 6/2
6:53 pm-11:59 pm
1 stop5h 06m
Buffalo
Sat 6/6
1:29 pm-7:18 pm
1 stop5h 49m
$275
SavannahBuffalo
SAV - BUF
SAVBUF
Savannah/Hilton Head
Sat 5/16
6:57 pm-11:49 pm
1 stop4h 52m
Buffalo
Wed 5/20
5:30 am-10:49 am
1 stop5h 19m
$283
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from South Carolina with our price prediction graph.
CLT-BUF
SAV-BUF
CHS-BUF
CAE-BUF
GSP-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Buffalo
USSC-BUF
CLT-BUF
SAV-BUF
CHS-BUF
CAE-BUF
How far ahead should I book a flight from South Carolina to Buffalo?
The best time to book flights from South Carolina to Buffalo is 27 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from South Carolina to Buffalo?
Currently, November is the cheapest month in which you can book a flight from South Carolina to Buffalo (average of $76). Flying from South Carolina to Buffalo in December is currently the most expensive (average of $241). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from South Carolina to Buffalo?
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Buffalo flight routes
Complete your trip
Flights by cabin class
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Top destinations
Alternative routes for South Carolina to Buffalo
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 6, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Buffalo by cabin class
Find flights from South Carolina to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Buffalo flights
Browse other South Carolina and Buffalo flight options. Last updated on May 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Buffalo flights
Consider these flights traveling from South Carolina to Buffalo.
Top 5 airlines flying from South Carolina to Buffalo
Discover the top 5 airlines that operate flights from South Carolina to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$80 | Average$200 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$118 | Average$324 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$195 | Average$361 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$397 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$248 | Average$344 | FlexibilityNo cancel fee | On-time69% |