$131+ Cheap flights from South Carolina to Buffalo (BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BUF
Dec 5 — Dec 121
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to BuffaloExplore the most affordable flight options available from South Carolina to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2026.
Explore the most affordable flight options available from South Carolina to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2026.
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:04 am -
1 stop5h 37m
Tue 12/86:52 pm -
1 stop3h 59m
Deal found 11/3![American Airlines logo]()
$261
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:00 am -
1 stop4h 35m
Mon 11/306:00 am -
1 stop4h 13m
Deal found 11/2![Delta logo]()
$271
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/292:55 pm -
1 stop7h 38m
Sat 1/26:00 am -
1 stop5h 20m
Deal found 11/4![Delta logo]()
$276
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1612:15 pm -
2 stops11h 19m
Tue 1/52:52 pm -
1 stop4h 16m
Deal found 11/3![United Airlines logo]()
$289
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:53 pm -
1 stop4h 35m
Thu 11/266:00 am -
1 stop7h 23m
Deal found 11/1![Delta logo]()
$290
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/286:47 pm -
1 stop5h 14m
Sun 1/36:59 pm -
1 stop4h 55m
Deal found 11/5![Delta logo]()
$291
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/198:10 pm -
1 stop4h 04m
Wed 12/237:47 pm -
1 stop4h 12m
Deal found 11/1![American Airlines logo]()
$300
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:00 am -
1 stop4h 05m
Fri 12/46:10 am -
1 stop4h 02m
Deal found 11/4![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/217:03 pm -
1 stop4h 52m
Mon 1/46:00 am -
1 stop5h 29m
Deal found 11/4![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:30 am -
2 stops7h 50m
Tue 12/810:30 am -
1 stop6h 23m
Deal found 11/1![United Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1911:19 am -
1 stop6h 12m
Tue 11/246:00 am -
1 stop4h 14m
Deal found 11/3![Delta logo]()
$314
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:30 am -
1 stop6h 40m
Mon 12/1410:00 am -
2 stops7h 34m
Deal found 11/3![United Airlines logo]()
$314
Best flights from South Carolina to BuffaloDiscover carefully curated flight deals from South Carolina to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 5, 2026.
Discover carefully curated flight deals from South Carolina to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 5, 2026.
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/296:40 am -
2 stops8h 20m
Mon 2/110:15 am -
1 stop6h 30m
Deal found 11/2![Southwest logo]()
$266
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:00 am -
1 stop4h 35m
Mon 11/306:00 am -
1 stop4h 13m
Deal found 11/2![Delta logo]()
$271
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:30 am -
2 stops7h 50m
Tue 12/810:30 am -
1 stop6h 23m
Deal found 11/1![United Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:54 pm -
1 stop4h 45m
Mon 12/77:03 am -
1 stop5h 00m
Deal found 11/4![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/286:47 pm -
1 stop5h 14m
Sun 1/36:59 pm -
1 stop4h 55m
Deal found 11/5![Delta logo]()
$291
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:30 am -
1 stop6h 40m
Mon 12/1410:00 am -
2 stops7h 34m
Deal found 11/3![United Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1911:19 am -
1 stop6h 12m
Tue 11/246:00 am -
1 stop4h 14m
Deal found 11/3![Delta logo]()
$314
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/56:15 am -
2 stops8h 02m
Tue 1/127:03 am -
1 stop4h 45m
Deal found 10/31![United Airlines logo]()
$316
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/286:10 am -
1 stop7h 10m
Sat 5/112:45 pm -
1 stop3h 25m
Deal found 11/2![Southwest logo]()
$353
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/162:18 pm -
2 stops9h 43m
Thu 12/316:00 am -
1 stop4h 39m
Deal found 11/5![Delta logo]()
$314
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/23:02 pm -
1 stop4h 17m
Wed 12/93:00 pm -
1 stop4h 23m
Deal found 11/4![United Airlines logo]()
$325
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/288:25 am -
1 stop3h 45m
Sun 5/23:50 pm -
1 stop3h 45m
Deal found 11/1![Southwest logo]()
$368
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/265:10 pm -
1 stop6h 00m
Sun 1/36:59 pm -
1 stop4h 55m
Deal found 11/5![Delta logo]()
$315
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:00 am -
2 stops8h 20m
Mon 12/1411:23 am -
2 stops9h 58m
Deal found 11/3![United Airlines logo]()
$372
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/292:38 pm -
2 stops8h 35m
Sun 1/3112:20 pm -
1 stop5h 56m
Deal found 11/2![Delta logo]()
$344
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:40 am -
2 stops7h 45m
Sun 11/225:30 pm -
1 stop4h 15m
Deal found 11/1![Southwest logo]()
$455
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:53 pm -
1 stop4h 35m
Mon 11/306:00 am -
1 stop4h 13m
Deal found 11/2![Delta logo]()
$350
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/144:07 pm -
2 stops5h 57m
Fri 2/196:00 am -
2 stops6h 36m
Deal found 11/4![American Airlines logo]()
$587
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/233:29 pm -
1 stop5h 07m
Sat 11/286:00 am -
1 stop4h 09m
Deal found 11/2![United Airlines logo]()
$402
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/281:05 pm -
1 stop5h 33m
Sat 5/19:00 am -
2 stops8h 55m
Deal found 11/2![Delta logo]()
$358
This Southwest deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/188:05 am -
2 stops9h 35m
Wed 11/254:30 pm -
1 stop6h 55m
Deal found 10/31![Southwest logo]()
$482
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:30 am -
1 stop6h 47m
Sat 12/121:53 pm -
1 stop7h 06m
Deal found 11/3![United Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/185:00 am -
2 stops7h 00m
Tue 1/56:03 am -
1 stop6h 42m
Deal found 11/1![American Airlines logo]()
$627
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/66:15 am -
1 stop7h 00m
Tue 2/95:43 pm -
1 stop7h 02m
Deal found 11/4![United Airlines logo]()
$421
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/188:05 pm -
1 stop3h 45m
Sun 12/2012:40 pm -
2 stops10h 45m
Deal found 11/2![Southwest logo]()
$512
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:19 pm -
1 stop4h 40m
Thu 11/263:30 pm -
1 stop6h 42m
Deal found 11/4![Delta logo]()
$418
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:00 am -
2 stops7h 20m
Tue 11/246:00 am -
2 stops12h 06m
Deal found 11/3![United Airlines logo]()
$434
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/172:52 pm -
1 stop4h 12m
Sat 11/211:53 pm -
1 stop7h 09m
Deal found 11/2![United Airlines logo]()
$469
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:57 pm -
1 stop14h 21m
Thu 11/263:30 pm -
1 stop4h 31m
Deal found 11/4![Delta logo]()
$504
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/122:29 pm -
2 stops9h 05m
Fri 1/85:45 am -
2 stops11h 13m
Deal found 11/1![United Airlines logo]()
$478
Last-minute flights from South Carolina to BuffaloDiscover last-minute flight deals from South Carolina to Buffalo. Data last updated November 5, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Buffalo. Data last updated November 5, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1911:19 am -
1 stop6h 12m
Tue 11/246:00 am -
1 stop4h 14m
Deal found 11/3![Delta logo]()
$314
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:00 am -
1 stop4h 35m
Mon 11/306:00 am -
1 stop4h 13m
Deal found 11/2![Delta logo]()
$271
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:53 pm -
1 stop4h 35m
Thu 11/266:00 am -
1 stop7h 23m
Deal found 11/1![Delta logo]()
$290
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:00 am -
1 stop4h 05m
Fri 12/46:10 am -
1 stop4h 02m
Deal found 11/4![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:30 am -
2 stops7h 50m
Tue 12/810:30 am -
1 stop6h 23m
Deal found 11/1![United Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:04 am -
1 stop5h 37m
Tue 12/86:52 pm -
1 stop3h 59m
Deal found 11/3![American Airlines logo]()
$261
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:30 am -
1 stop6h 40m
Mon 12/1410:00 am -
2 stops7h 34m
Deal found 11/3![United Airlines logo]()
$314
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1612:15 pm -
2 stops11h 19m
Tue 1/52:52 pm -
1 stop4h 16m
Deal found 11/3![United Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/198:10 pm -
1 stop4h 04m
Wed 12/237:47 pm -
1 stop4h 12m
Deal found 11/1![American Airlines logo]()
$300
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/217:03 pm -
1 stop4h 52m
Mon 1/46:00 am -
1 stop5h 29m
Deal found 11/4![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/286:47 pm -
1 stop5h 14m
Sun 1/36:59 pm -
1 stop4h 55m
Deal found 11/5![Delta logo]()
$291
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/292:55 pm -
1 stop7h 38m
Sat 1/26:00 am -
1 stop5h 20m
Deal found 11/4![Delta logo]()
$276
One-way flights from South Carolina to BuffaloSearch for one-way flight options from South Carolina to Buffalo. Find affordable one-way fares based on user searches. Data last updated November 5, 2026.
Search for one-way flight options from South Carolina to Buffalo. Find affordable one-way fares based on user searches. Data last updated November 5, 2026.
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:00 am -
1 stop4h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Delta logo]()
$131
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2312:18 pm -
2 stops10h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![United Airlines logo]()
$139
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/276:47 pm -
1 stop5h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![Delta logo]()
$146
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:25 pm -
1 stop4h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Delta logo]()
$155
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:30 am -
2 stops7h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![United Airlines logo]()
$160
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:51 am -
1 stop3h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![American Airlines logo]()
$170
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:14 pm -
1 stop3h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![American Airlines logo]()
$171
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/227:00 am -
1 stop3h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![American Airlines logo]()
$177
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/172:40 pm -
1 stop7h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![American Airlines logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/173:00 pm -
2 stops22h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Multiple Airlines logo]()
$187
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:20 am -
1 stop5h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![Delta logo]()
$189
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/171:00 pm -
2 stops10h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Southwest logo]()
$190
Find flight deals from South Carolina to Buffalo
Keep the following information in mind while searching for South Carolina to Buffalo flight deals. Data was last updated November 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $261 (Delta) |
One-way from | $131 (Delta) |
Popular in | July |
Cheapest in | January |
Average price | $396 |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 5, 2026.
Use the filters below to find and compare flights from South Carolina to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonBuffalo
CHS Charleston - BUF Buffalo
CHSBUF
Charleston
Mon 11/23
6:00 am-10:35 am
1 stop4h 35m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$131
CharlestonBuffalo
CHS Charleston - BUF Buffalo
CHSBUF
Charleston
Sun 12/27
6:47 pm-12:01 am
1 stop5h 14m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$146
Quickest round-trip
GreenvilleBuffalo
GSP Greenville - BUF Buffalo
GSPBUF
Greenville
Wed 12/23
8:05 pm-11:50 pm
1 stop3h 45m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$155
GreenvilleBuffalo
GSP Greenville - BUF Buffalo
GSPBUF
Greenville
Thu 12/17
7:25 pm-12:04 am
1 stop4h 39m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$155
CharlestonBuffalo
CHS Charleston - BUF Buffalo
CHSBUF
Charleston
Mon 11/23
12:18 pm-10:59 pm
2 stops10h 41m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$159
GreenvilleBuffalo
GSP Greenville - BUF Buffalo
GSPBUF
Greenville
Wed 12/16
6:30 am-2:20 pm
2 stops7h 50m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$160
ColumbiaBuffalo
CAE Columbia Metropolitan - BUF Buffalo
CAEBUF
Columbia Metropolitan
Fri 12/25
6:51 am-10:40 am
1 stop3h 49m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$170
CharlestonBuffalo
CHS Charleston - BUF Buffalo
CHSBUF
Charleston
Tue 11/24
7:20 am-11:59 am
1 stop4h 39m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$184
CharlestonBuffalo
CHS Charleston - BUF Buffalo
CHSBUF
Charleston
Sat 11/21
5:20 am-11:06 am
1 stop5h 46m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$184
CharlestonBuffalo
CHS Charleston - BUF Buffalo
CHSBUF
Charleston
Tue 11/24
5:20 am-11:06 am
1 stop5h 46m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$189
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from South Carolina with our price prediction graph.
CHS-BUF
GSP-BUF
CAE-BUF
MYR-BUF
HHH-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Buffalo
USSC-BUF
CHS-BUF
GSP-BUF
CAE-BUF
MYR-BUF
What is the cheapest month to book a flight from South Carolina to Buffalo?
Currently, January is the cheapest month in which you can book a flight from South Carolina to Buffalo (average of $290). Flying from South Carolina to Buffalo in March is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from South Carolina to Buffalo?
Airfare is typical for this route at the moment.
South Carolina to Buffalo flights typically cost between $260 and $361 in January.The cheapest round-trip price found within the last 5 days was $261 on Delta (Jan 8-Jan 11).
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Buffalo flight routes
Complete your trip
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Alternative routes for South Carolina to Buffalo
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 5, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Buffalo by cabin class
Find flights from South Carolina to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Buffalo flights
Browse other South Carolina and Buffalo flight options. Last updated on November 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Buffalo flights
Consider these flights traveling from South Carolina to Buffalo.
Top 3 airlines flying from South Carolina to Buffalo
Discover the top 3 airlines that operate flights from South Carolina to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$128 | Average$335 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$200 | Average$354 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$211 | Average$431 | FlexibilityNo cancel fee | On-time63% |