$89+ Cheap flights from South Carolina to Buffalo (BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/7. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BUF
Oct 18 — Oct 251
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to BuffaloExplore the most affordable flight options available from South Carolina to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
Explore the most affordable flight options available from South Carolina to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:08 pm -
1 stop3h 42m
Tue 10/136:08 am -
1 stop5h 06m
Deal found 9/15![American Airlines logo]()
$177
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1411:05 am -
1 stop4h 09m
Mon 10/2612:08 pm -
1 stop7h 24m
Deal found 9/15![JetBlue logo]()
$181
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1411:05 am -
1 stop4h 09m
Thu 10/2912:08 pm -
1 stop7h 24m
Deal found 9/15![JetBlue logo]()
$182
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1511:05 am -
1 stop4h 36m
Sat 10/247:00 am -
1 stop7h 12m
Deal found 9/15![JetBlue logo]()
$187
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1012:25 pm -
1 stop7h 34m
Sat 10/247:00 am -
1 stop7h 12m
Deal found 9/15![JetBlue logo]()
$188
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1511:05 am -
1 stop4h 36m
Mon 10/2612:08 pm -
1 stop7h 24m
Deal found 9/15![JetBlue logo]()
$191
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1012:25 pm -
1 stop7h 34m
Mon 10/2612:08 pm -
1 stop7h 24m
Deal found 9/15![JetBlue logo]()
$192
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1012:25 pm -
1 stop7h 34m
Thu 10/2912:08 pm -
1 stop7h 24m
Deal found 9/15![JetBlue logo]()
$193
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:10 pm -
1 stop4h 49m
Mon 10/262:10 pm -
1 stop6h 33m
Deal found 9/15![Delta logo]()
$197
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:05 pm -
1 stop3h 40m
Mon 10/195:45 pm -
1 stop4h 00m
Deal found 9/18![Southwest logo]()
$198
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/305:50 am -
1 stop3h 55m
Tue 1/57:00 am -
1 stop7h 25m
Deal found 9/14![United Airlines logo]()
$203
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:10 pm -
1 stop4h 49m
Fri 10/236:55 pm -
1 stop5h 04m
Deal found 9/15![Delta logo]()
$208
Best flights from South Carolina to BuffaloDiscover carefully curated flight deals from South Carolina to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
Discover carefully curated flight deals from South Carolina to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
This JetBlue deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1711:05 am -
1 stop4h 18m
Mon 10/197:00 am -
1 stop7h 12m
Deal found 9/17![JetBlue logo]()
$182
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:20 am -
1 stop5h 10m
Mon 11/98:05 am -
1 stop5h 15m
Deal found 9/17![Southwest logo]()
$187
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:05 am -
1 stop4h 33m
Fri 10/236:55 pm -
1 stop5h 04m
Deal found 9/15![Delta logo]()
$208
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:28 am -
1 stop5h 34m
Thu 10/296:00 am -
1 stop5h 00m
Deal found 9/14![United Airlines logo]()
$296
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/224:35 pm -
1 stop7h 04m
Tue 12/15:30 am -
2 stops8h 51m
Deal found 9/17![American Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/611:00 am -
2 stops10h 45m
Mon 1/115:50 am -
1 stop4h 25m
Deal found 9/13![Southwest logo]()
$193
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:05 pm -
1 stop3h 40m
Mon 10/195:45 pm -
1 stop4h 00m
Deal found 9/18![Southwest logo]()
$198
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1411:15 am -
1 stop6h 34m
Sun 10/186:00 am -
1 stop4h 33m
Deal found 9/15![Delta logo]()
$229
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:30 am -
1 stop4h 35m
Fri 11/133:05 pm -
1 stop4h 10m
Deal found 9/14![Southwest logo]()
$198
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:50 pm -
1 stop5h 09m
Sun 10/256:00 am -
1 stop4h 33m
Deal found 9/16![Delta logo]()
$240
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/71:25 pm -
1 stop3h 35m
Mon 1/115:50 am -
2 stops9h 00m
Deal found 9/13![Southwest logo]()
$203
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:30 am -
1 stop5h 41m
Wed 12/26:00 am -
1 stop5h 38m
Deal found 9/15![Delta logo]()
$255
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/182:19 pm -
1 stop6h 17m
Thu 11/266:30 am -
1 stop7h 10m
Deal found 9/18![United Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/88:00 am -
1 stop4h 00m
Mon 1/115:50 am -
2 stops9h 00m
Deal found 9/13![Southwest logo]()
$214
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/222:56 pm -
1 stop4h 07m
Sun 10/255:50 am -
1 stop5h 15m
Deal found 9/15![American Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:33 pm -
1 stop4h 17m
Mon 10/192:55 pm -
2 stops7h 01m
Deal found 9/15![American Airlines logo]()
$360
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:30 am -
1 stop6h 55m
Mon 11/94:00 pm -
2 stops7h 55m
Deal found 9/17![Southwest logo]()
$247
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:35 pm -
1 stop5h 24m
Sun 11/12:10 pm -
1 stop7h 48m
Deal found 9/17![Delta logo]()
$299
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:43 pm -
1 stop4h 03m
Tue 11/36:00 am -
1 stop3h 51m
Deal found 9/15![United Airlines logo]()
$372
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/303:24 pm -
2 stops7h 35m
Tue 1/56:40 am -
2 stops7h 38m
Deal found 9/13![American Airlines logo]()
$360
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:55 am -
1 stop6h 40m
Tue 10/2012:35 pm -
2 stops8h 35m
Deal found 9/17![Southwest logo]()
$260
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/210:23 am -
1 stop4h 00m
Tue 10/66:30 am -
1 stop5h 08m
Deal found 9/17![United Airlines logo]()
$393
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:28 pm -
1 stop6h 36m
Mon 11/26:21 pm -
1 stop4h 36m
Deal found 9/13![American Airlines logo]()
$390
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1412:23 pm -
1 stop5h 26m
Tue 10/276:00 am -
1 stop5h 43m
Deal found 9/15![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/141:10 pm -
1 stop5h 10m
Tue 10/2011:05 am -
1 stop6h 20m
Deal found 9/16![Southwest logo]()
$274
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:54 pm -
1 stop5h 05m
Wed 11/1110:51 am -
1 stop6h 20m
Deal found 9/15![United Airlines logo]()
$418
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:51 pm -
1 stop5h 08m
Sun 11/156:00 am -
1 stop5h 37m
Deal found 9/17![Delta logo]()
$357
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:15 am -
2 stops8h 08m
Sat 10/1710:10 am -
1 stop4h 16m
Deal found 9/15![United Airlines logo]()
$428
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/222:10 pm -
1 stop4h 30m
Mon 10/2612:35 pm -
2 stops7h 25m
Deal found 9/16![Southwest logo]()
$298
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:00 am -
1 stop5h 10m
Mon 1/46:59 pm -
1 stop5h 00m
Deal found 9/13![Delta logo]()
$363
Last-minute flights from South Carolina to BuffaloDiscover last-minute flight deals from South Carolina to Buffalo. Data last updated September 18, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Buffalo. Data last updated September 18, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/104:52 pm -
1 stop5h 58m
Tue 10/2012:55 pm -
1 stop3h 49m
Deal found 9/15![American Airlines logo]()
$177
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1012:25 pm -
1 stop7h 34m
Sat 10/247:00 am -
1 stop7h 12m
Deal found 9/15![JetBlue logo]()
$188
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1012:25 pm -
1 stop7h 34m
Mon 10/2612:08 pm -
1 stop7h 24m
Deal found 9/15![JetBlue logo]()
$192
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1012:25 pm -
1 stop7h 34m
Thu 10/2912:08 pm -
1 stop7h 24m
Deal found 9/15![JetBlue logo]()
$193
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:10 pm -
1 stop4h 49m
Mon 10/262:10 pm -
1 stop6h 33m
Deal found 9/15![Delta logo]()
$197
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:10 pm -
1 stop4h 49m
Fri 10/236:55 pm -
1 stop5h 04m
Deal found 9/15![Delta logo]()
$208
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1411:05 am -
1 stop4h 09m
Mon 10/2612:08 pm -
1 stop7h 24m
Deal found 9/15![JetBlue logo]()
$181
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1411:05 am -
1 stop4h 09m
Thu 10/2912:08 pm -
1 stop7h 24m
Deal found 9/15![JetBlue logo]()
$182
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1511:05 am -
1 stop4h 36m
Sat 10/247:00 am -
1 stop7h 12m
Deal found 9/15![JetBlue logo]()
$187
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1511:05 am -
1 stop4h 36m
Mon 10/2612:08 pm -
1 stop7h 24m
Deal found 9/15![JetBlue logo]()
$191
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:05 pm -
1 stop3h 40m
Mon 10/195:45 pm -
1 stop4h 00m
Deal found 9/18![Southwest logo]()
$198
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:33 pm -
1 stop4h 17m
Tue 10/206:51 pm -
1 stop3h 59m
Deal found 9/16![American Airlines logo]()
$216
One-way flights from South Carolina to BuffaloSearch for one-way flight options from South Carolina to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
Search for one-way flight options from South Carolina to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:20 am -
1 stop5h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$89
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:30 am -
1 stop6h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$102
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:05 pm -
1 stop3h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Southwest logo]()
$110
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:45 am -
1 stop5h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![American Airlines logo]()
$114
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:26 pm -
1 stop5h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Delta logo]()
$115
This Super.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/149:42 pm -
1 stop20h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Frontier logo]()
$120
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:20 pm -
2 stops9h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Southwest logo]()
$121
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:33 pm -
1 stop4h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![American Airlines logo]()
$127
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:55 am -
1 stop6h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$128
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:20 am -
1 stop4h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![JetBlue logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/179:32 am -
2 stops27h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Frontier logo]()
$132
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:40 am -
2 stops8h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Southwest logo]()
$133
Find flight deals from South Carolina to Buffalo
Keep the following information in mind while searching for South Carolina to Buffalo flight deals. Data was last updated September 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $177 (American Airlines) |
One-way from | $89 (Southwest) |
Popular in | July |
Cheapest in | January |
Average price | $375 |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
Use the filters below to find and compare flights from South Carolina to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonBuffalo
CHS Charleston - BUF Buffalo
CHSBUF
Charleston
Sat 11/7
8:20 am-1:30 pm
1 stop5h 10m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$89
SavannahBuffalo
SAV Savannah/Hilton Head - BUF Buffalo
SAVBUF
Savannah/Hilton Head
Sat 10/17
6:30 am-2:35 pm
2 stops8h 05m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$108
SavannahBuffalo
SAV Savannah/Hilton Head - BUF Buffalo
SAVBUF
Savannah/Hilton Head
Thu 12/17
6:26 pm-12:05 am
1 stop5h 39m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$115
CharlotteBuffalo
CLT Charlotte Douglas - BUF Buffalo
CLTBUF
Charlotte Douglas
Sat 10/17
7:55 am-2:35 pm
1 stop6h 40m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$128
CharlotteBuffalo
CLT Charlotte Douglas - BUF Buffalo
CLTBUF
Charlotte Douglas
Wed 11/4
8:05 am-12:05 pm
1 stop4h 00m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$128
CharlestonBuffalo
CHS Charleston - BUF Buffalo
CHSBUF
Charleston
Wed 11/25
8:14 pm-12:05 am
1 stop3h 51m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$131
CharlestonBuffalo
CHS Charleston - BUF Buffalo
CHSBUF
Charleston
Wed 11/25
7:20 am-11:59 am
1 stop4h 39m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$131
CharlotteBuffalo
CLT Charlotte Douglas - BUF Buffalo
CLTBUF
Charlotte Douglas
Wed 10/14
6:40 am-3:20 pm
2 stops8h 40m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$133
SavannahBuffalo
SAV Savannah/Hilton Head - BUF Buffalo
SAVBUF
Savannah/Hilton Head
Fri 10/23
1:20 pm-9:10 pm
2 stops7h 50m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$133
GreenvilleBuffalo
GSP Greenville - BUF Buffalo
GSPBUF
Greenville
Mon 10/12
3:38 pm-10:59 pm
1 stop7h 21m
Buffalo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$147
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from South Carolina with our price prediction graph.
CHS-BUF
SAV-BUF
GSP-BUF
HHH-BUF
CLT-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Buffalo
USSC-BUF
CHS-BUF
SAV-BUF
GSP-BUF
HHH-BUF
What is the cheapest month to book a flight from South Carolina to Buffalo?
Currently, February is the cheapest month in which you can book a flight from South Carolina to Buffalo (average of $304). Flying from South Carolina to Buffalo in March is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from South Carolina to Buffalo?
Airfare is below average for this route at the moment.
South Carolina to Buffalo flights typically cost between $260 and $379 in October.The cheapest round-trip price found within the last 5 days was $177 on American Airlines (Oct 10-Oct 20).
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Buffalo flight routes
Complete your trip
Flights by cabin class
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Alternative routes for South Carolina to Buffalo
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 18, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Buffalo by cabin class
Find flights from South Carolina to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Buffalo flights
Browse other South Carolina and Buffalo flight options. Last updated on September 18, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Buffalo flights
Consider these flights traveling from South Carolina to Buffalo.
Top 4 airlines flying from South Carolina to Buffalo
Discover the top 4 airlines that operate flights from South Carolina to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$76 | Average$189 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$128 | Average$340 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$200 | Average$379 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$436 | FlexibilityNo cancel fee | On-time63% |