$490+ Cheap flights from San Diego to Florence, SC (SAN - FLO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — FLO
Dec 13 — Dec 201
1 adult, Economy
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Cheapest flights from San Diego to FlorenceExplore the most affordable flight options available from San Diego to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.
Explore the most affordable flight options available from San Diego to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/261:44 pmSAN - FLO
1 stop6h 57mAmerican Airlines
Mon 12/15:15 amFLO - SAN
1 stop8h 56mAmerican Airlines
Deal found 11/12![American Airlines logo]()
$785
Cheap flight deals from San Diego to Florence
Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 13, 2025.
Most accurate provider | Expedia 2 stars |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $632 (American Airlines) |
One-way from | $490 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from San Diego to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from San Diego to Florence that are best for you.
Fly from
San Diego
Fly to
Florence
Route
Depart
Return
Price
San DiegoFlorence
SAN - FLO
SANFLO
San Diego
Wed 3/25
11:00 pm-10:24 am
1 stop8h 24m
Florence
Sat 3/28
5:13 am-11:10 am
1 stop8h 57m
$632
San DiegoFlorence
SAN - FLO
SANFLO
San Diego
Wed 11/26
1:44 pm-11:41 pm
1 stop6h 57m
Florence
Mon 12/1
5:15 am-11:11 am
1 stop8h 56m
$785
San DiegoFlorence
SAN - FLO
SANFLO
San Diego
Tue 11/25
12:01 pm-11:41 pm
1 stop8h 40m
$490
- Most accurate provider: When it comes to deals on San Diego-Florence, South Carolina flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on San Diego-Florence, South Carolina flight deals on Cheapflights vs. Expedia 90-95% of the time. Price accuracy is based on data collected from San Diego-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Diego-Florence, South Carolina flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Diego to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Diego to Florence
What is the cheapest month to book a flight from San Diego to Florence, South Carolina?
Currently, May is the cheapest month in which you can book a flight from San Diego to Florence, South Carolina (average of $145). Flying from San Diego to Florence, South Carolina in March is currently the most expensive (average of $283). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SAN to FLO?
Find hourly flight availability from San Diego to Florence. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.
Unlike in the afternoon, when flights are generally more expensive, you can save up to 46% on flights from San Diego to Florence, South Carolina by exploring options for tickets at noon.
Reviews of airlines servicing Florence
Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated November 13, 2025.
Read reviews from past customers who have flown American Airlines from San Diego to Florence. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.0
Entertainment
6.9
Boarding
7.5
Comfort
7.2
Overall
7.2
Food
6.4
Reviews
1 / 20
8.0
ExcellentMonica,Nov 2025
JAC - DFW
Crew
8.0
Entertainment
6.9
Boarding
7.5
Comfort
7.2
Overall
7.2
Food
6.4
Reviews
1 / 20
8.0
ExcellentMonica,Nov 2025
JAC - DFW
Related info for your journey
Find useful and relevant information for your journey from San Diego to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Florence?
Book flights to Florence if you plan to visit one of these locationsSumter
Hartsville
Darlington
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Alternative routes for San Diego to Florence
See prices for flight routes from nearby airports that may be better suited for you.
Top airline flying from San Diego to Florence
Discover the top airline that operate flights from San Diego to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$351 | Average$475 | FlexibilityNo cancel fee | On-time71% |