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$492+ Cheap flights from San Diego to Florence, SC (SAN - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/5. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — FLO
oct. 16 — oct. 231
jue. 10/16
jue. 10/23
1 adult, Economy
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Cheap flight deals from San Diego to Florence

Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 16, 2025.

Round-trip from

$492
(American Airlines)
From San Diego to Florence
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Find flight deals from San Diego to Florence

Cheapest flights from San Diego to Florence
Explore the most affordable flight options available from San Diego to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 16, 2025.

This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/1710:31 pmSAN - FLO
1 stop9h 15mAmerican Airlines
jue. 10/232:29 pmFLO - SAN
1 stop9h 04mAmerican Airlines
Deal found 9/16$519
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/297:00 amSAN - FLO
1 stop7h 12mAmerican Airlines
vie. 10/35:37 pmFLO - SAN
1 stop19h 43mAmerican Airlines
Deal found 9/14$915

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 16, 2025.
Use the filters below to find and compare flights from San Diego to Florence that are best for you.

Fly from

San Diego

Fly to

Florence

Route

Depart

Return

Price

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

lun. 1/5

10:01 pm-10:12 am

1 stop9h 11m

Florence

mar. 1/13

6:53 am-1:36 pm

1 stop9h 43m

$492

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

vie. 10/17

10:31 pm-10:46 am

1 stop9h 15m

Florence

jue. 10/23

2:29 pm-8:33 pm

1 stop9h 04m

$519

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

lun. 9/29

8:18 am-11:16 pm

2 stops11h 58m

Florence

vie. 10/3

5:37 pm-10:20 am

1 stop19h 43m

$920

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Best time to book a flight from San Diego to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Florence

What is the cheapest month to book a flight from San Diego to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from San Diego to Florence, South Carolina (average of $366). Flying from San Diego to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to FLO?

Find hourly flight availability from San Diego to Florence. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 16, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 35% on flights from San Diego to Florence, South Carolina by exploring options for tickets at noon.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated septiembre 16, 2025.
Read reviews from past customers who have flown American Airlines from San Diego to Florence. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Food

6.4

Comfort

7.2

Entertainment

6.9

Boarding

7.5

Overall

7.2

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Food

6.4

Comfort

7.2

Entertainment

6.9

Boarding

7.5

Overall

7.2

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from San Diego to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Diego to Florence, South Carolina?

    Airlines like American Airlines fly from San Diego to Florence, South Carolina in about 9h 11m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 2149 mi.

  • What is the cheapest airline to fly from San Diego to Florence, South Carolina round-trip?

    Cheapflights users have booked flights from San Diego to Florence, South Carolina round-trip from $351.

  • Can I find deals for flights from San Diego to Florence that include hotel bookings?

    Yes. In addition to deals on San Diego to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Florence.

  • Can I find deals for business class flights from San Diego to Florence?

    Yes. Cheapflights offers flight deals from San Diego to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from San Diego to Florence, South Carolina (average of $366). Flying from San Diego to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from San Diego to Florence

Discover the top airline that operate flights from San Diego to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$351Average$491FlexibilityNo cancel feeOn-time71%

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