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$539+ Cheap flights from San Diego to Florence, SC (SAN - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/9. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — FLO
Feb 21 — Feb 281
Sat 2/21
Sat 2/28
1 adult, Economy
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Cheap flight deals from San Diego to Florence

Cheapest flights from San Diego to Florence
Explore the most affordable flight options available from San Diego to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 22, 2026.

This American Airlines deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/91:36 pm
SAN
-
FLO
1 stop7h 17m
American Airlines
Thu 4/235:24 am
FLO
-
SAN
1 stop8h 50m
American Airlines
Deal found 1/22$539
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/77:00 am
SAN
-
FLO
1 stop7h 09m
American Airlines
Sat 2/145:16 am
FLO
-
SAN
1 stop9h 01m
American Airlines
Deal found 1/19$699
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/612:40 pm
SAN
-
FLO
1 stop7h 03m
American Airlines
Sat 2/145:16 am
FLO
-
SAN
1 stop9h 01m
American Airlines
Deal found 1/19$741

Find flight deals from San Diego to Florence

Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 22, 2026.

Most accurate provider

Expedia
2 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$539
(American Airlines)
Provider with most accurate pricing for San Diego-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Diego-Florence flights.
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From San Diego to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 22, 2026.
Use the filters below to find and compare flights from San Diego to Florence that are best for you.

Fly from

San Diego

Fly to

Florence

Route

Depart

Return

Price

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Thu 4/9

1:36 pm-11:53 pm

1 stop7h 17m

Florence

Thu 4/23

4:16 pm-8:52 pm

1 stop7h 36m

$539

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Sat 2/7

7:00 am-5:09 pm

1 stop7h 09m

Florence

Sat 2/14

5:16 am-11:17 am

1 stop9h 01m

$699

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Sat 2/7

12:40 pm-11:11 pm

1 stop7h 31m

Florence

Sun 2/15

5:16 am-11:17 am

1 stop9h 01m

$741

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Fri 2/6

12:40 pm-10:43 pm

1 stop7h 03m

Florence

Sat 2/14

5:16 am-11:17 am

1 stop9h 01m

$741

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/21

  • Most accurate provider: When it comes to deals on San Diego-Florence, South Carolina flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on San Diego-Florence, South Carolina flight deals on Cheapflights vs. Expedia 90-95% of the time. Price accuracy is based on data collected from San Diego-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Diego-Florence, South Carolina flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Diego to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Florence

What is the cheapest month to book a flight from San Diego to Florence, South Carolina?

Currently, December is the cheapest month in which you can book a flight from San Diego to Florence, South Carolina (average of $111). Flying from San Diego to Florence, South Carolina in March is currently the most expensive (average of $275). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from San Diego to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Diego to Florence, South Carolina?

    Airlines like American Airlines fly from San Diego to Florence, South Carolina in about 7h 17m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 2149 mi.

  • Can I find deals for flights from San Diego to Florence that include hotel bookings?

    Yes. In addition to deals on San Diego to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Florence.

  • Can I find deals for business class flights from San Diego to Florence?

    Yes. Cheapflights offers flight deals from San Diego to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to Florence, South Carolina?

    Currently, December is the cheapest month in which you can book a flight from San Diego to Florence, South Carolina (average of $111). Flying from San Diego to Florence, South Carolina in March is currently the most expensive (average of $275). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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