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$281+ Cheap flights from Minneapolis to Florence, SC (MSP - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel.
MSP — FLO
Feb 14 — Feb 211
Sat 2/14
Sat 2/21
1 adult, Economy
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Cheap flight deals from Minneapolis to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Minneapolis (MSP) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 15, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$447
(American Airlines)

One-way from

$281
(American Airlines)
Provider with most accurate pricing for Minneapolis St Paul-Florence flight deals.
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Provider most trusted by Cheapflights users for Minneapolis St Paul-Florence flights.
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From Minneapolis St Paul to Florence
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One-way flight from Minneapolis St Paul to Florence
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Find flight deals from Minneapolis to Florence

Cheapest flights from Minneapolis to Florence
Explore the most affordable flight options available from Minneapolis to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 15, 2026.

This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:05 pm
MSP
-
FLO
1 stop5h 52m
American Airlines
Wed 2/186:15 am
FLO
-
MSP
1 stop4h 56m
American Airlines
Deal found 1/12$295
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/15:25 pm
MSP
-
FLO
1 stop5h 31m
American Airlines
Sat 8/811:15 am
FLO
-
MSP
1 stop6h 54m
American Airlines
Deal found 1/13$435
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/294:00 pm
MSP
-
FLO
1 stop5h 43m
American Airlines
Mon 2/25:36 pm
FLO
-
MSP
1 stop4h 50m
American Airlines
Deal found 1/14$447
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2911:05 am
MSP
-
FLO
1 stop5h 04m
American Airlines
Thu 2/56:15 am
FLO
-
MSP
2 stops11h 45m
American Airlines
Deal found 1/13$452
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/83:51 pm
MSP
-
FLO
1 stop7h 02m
American Airlines
Mon 5/114:16 pm
FLO
-
MSP
2 stops8h 43m
American Airlines
Deal found 1/14$524

Cheapflights Fare Finder

 
Customize your flight search to find flights from Minneapolis to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
Use the filters below to find and compare flights from Minneapolis to Florence that are best for you.

Fly from

Minneapolis

Fly to

Florence

Route

Depart

Return

Price

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Sat 2/14

5:05 pm-11:57 pm

1 stop5h 52m

Florence

Wed 2/18

6:15 am-10:11 am

1 stop4h 56m

$295

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Thu 1/29

4:00 pm-10:43 pm

1 stop5h 43m

Florence

Mon 2/2

5:36 pm-9:26 pm

1 stop4h 50m

$447

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Thu 1/29

4:47 pm-10:43 pm

1 stop4h 56m

Florence

Thu 2/5

5:36 pm-9:26 pm

1 stop4h 50m

$447

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Wed 4/1

5:00 am-11:57 pm

2 stops17h 57m

$281

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Tue 3/31

5:00 am-11:08 pm

2 stops17h 08m

$281

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Mon 3/30

6:14 pm-11:08 pm

2 stops27h 54m

$410

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Sat 3/28

7:40 am-11:57 pm

2 stops15h 17m

$470

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Sun 3/29

10:47 am-11:57 pm

2 stops12h 10m

$493

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/14

Compare providers for flights from Minneapolis to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Minneapolis to Florence in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Minneapolis-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Minneapolis-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Minneapolis-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Minneapolis-Florence, South Carolina flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Minneapolis-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Minneapolis to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Minneapolis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Minneapolis to Florence

What is the cheapest month to book a flight from Minneapolis to Florence, South Carolina?

Currently, May is the cheapest month in which you can book a flight from Minneapolis to Florence, South Carolina (average of $69). Flying from Minneapolis to Florence, South Carolina in December is currently the most expensive (average of $229). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Minneapolis to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Minneapolis to Florence, South Carolina?

    There are many flights that can get you from Minneapolis to Florence, South Carolina in 5h 52m. Fly via American Airlines to get the fastest option. The distance from Minneapolis to Florence, South Carolina is about 1027 mi.

  • Can I find deals for flights from Minneapolis to Florence that include hotel bookings?

    Yes. In addition to deals on Minneapolis to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Minneapolis to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Minneapolis to Florence.

  • Can I find deals for business class flights from Minneapolis to Florence?

    Yes. Cheapflights offers flight deals from Minneapolis to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Minneapolis to Florence, South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Minneapolis to Florence, South Carolina (average of $69). Flying from Minneapolis to Florence, South Carolina in December is currently the most expensive (average of $229). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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