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$506+ Cheap flights from Minneapolis to Florence, SC (MSP - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/22. Fares are subject to change and may not be available on all flights or dates of travel.
MSP — FLO
oct. 15 — oct. 221
mié. 10/15
mié. 10/22
1 adult, Economy
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Cheap flight deals from Minneapolis to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Minneapolis (MSP) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 15, 2025.

Round-trip from

$506
(American Airlines)
From Minneapolis St Paul to Florence
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Find flight deals from Minneapolis to Florence

Cheapest flights from Minneapolis to Florence
Explore the most affordable flight options available from Minneapolis to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/2210:49 amMSP - FLO
2 stops11h 52mAmerican Airlines
mié. 11/266:33 pmFLO - MSP
1 stop5h 35mAmerican Airlines
Deal found 9/14$506
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/2212:51 pmMSP - FLO
2 stops9h 50mAmerican Airlines
jue. 11/277:00 amFLO - MSP
1 stop5h 48mAmerican Airlines
Deal found 9/14$533
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/235:45 pmMSP - FLO
1 stop4h 56mAmerican Airlines
jue. 11/277:00 amFLO - MSP
1 stop5h 48mAmerican Airlines
Deal found 9/14$555

Cheapflights Fare Finder

 
Customize your flight search to find flights from Minneapolis to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 15, 2025.
Use the filters below to find and compare flights from Minneapolis to Florence that are best for you.

Fly from

Minneapolis

Fly to

Florence

Route

Depart

Return

Price

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

sáb. 11/22

10:49 am-11:41 pm

2 stops11h 52m

Florence

mié. 11/26

6:33 pm-11:08 pm

1 stop5h 35m

$506

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

sáb. 11/22

12:51 pm-11:41 pm

2 stops9h 50m

Florence

jue. 11/27

7:00 am-11:48 am

1 stop5h 48m

$533

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

dom. 11/23

5:45 pm-11:41 pm

1 stop4h 56m

Florence

jue. 11/27

7:00 am-11:48 am

1 stop5h 48m

$555

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Best time to book a flight from Minneapolis to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Minneapolis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Minneapolis to Florence

What is the cheapest month to book a flight from Minneapolis to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Minneapolis to Florence, South Carolina (average of $366). Flying from Minneapolis to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Minneapolis to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Minneapolis to Florence, South Carolina?

    There are many flights that can get you from Minneapolis to Florence, South Carolina in 11h 52m. Fly via American Airlines to get the fastest option. The distance from Minneapolis to Florence, South Carolina is about 1027 mi.

  • Can I find deals for flights from Minneapolis to Florence that include hotel bookings?

    Yes. In addition to deals on Minneapolis to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Minneapolis to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Minneapolis to Florence.

  • Can I find deals for business class flights from Minneapolis to Florence?

    Yes. Cheapflights offers flight deals from Minneapolis to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Minneapolis to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Minneapolis to Florence, South Carolina (average of $366). Flying from Minneapolis to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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