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$108+ Cheap flights from Knoxville (TYS) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/2. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RDU
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Knoxville to Durham

Cheapest flights from Knoxville to Durham
Explore the most affordable flight options available from Knoxville to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:00 amTYS - RDU
1 stop6h 08mMultiple Airlines
Sat 11/229:37 amRDU - TYS
2 stops36h 26mMultiple Airlines
Deal found 10/29$200
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/124:32 pmTYS - RDU
1 stop27h 00mMultiple Airlines
Sun 11/169:35 pmRDU - TYS
1 stop16h 22mMultiple Airlines
Deal found 10/28$240
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/59:54 pmTYS - RDU
1 stop14h 04mMultiple Airlines
Sun 11/99:35 pmRDU - TYS
1 stop25h 39mMultiple Airlines
Deal found 10/29$259
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/148:40 amTYS - RDU
1 stop6h 42mMultiple Airlines
Tue 11/186:10 amRDU - TYS
2 stops30h 47mMultiple Airlines
Deal found 10/30$269
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:09 pmTYS - RDU
1 stop16h 22mMultiple Airlines
Sat 12/138:14 pmRDU - TYS
1 stop16h 18mMultiple Airlines
Deal found 10/28$290
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/57:59 pmTYS - RDU
1 stop3h 16mDelta
Sun 12/75:15 amRDU - TYS
1 stop4h 23mDelta
Deal found 10/29$317
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/267:00 amTYS - RDU
2 stops34h 47mMultiple Airlines
Wed 12/38:39 pmRDU - TYS
1 stop15h 14mMultiple Airlines
Deal found 10/27$319
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/255:28 pmTYS - RDU
1 stop15h 11mMultiple Airlines
Sun 11/308:45 pmRDU - TYS
1 stop25h 55mMultiple Airlines
Deal found 10/28$326

Cheap flight deals from Knoxville to Durham

Keep the following information in mind while searching for Knoxville to Durham flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$200
(Kiwi.com)

One-way from

$108
(Mytrip)

Popular in

September

Cheapest in

January

Average price

$317
Provider with most accurate pricing for Knoxville McGhee Tyson-Raleigh-Durham flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Raleigh-Durham flights.
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From Knoxville McGhee Tyson to Durham
Search Deals
One-way flight from Knoxville McGhee Tyson to Durham
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($18 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Knoxville to Durham that are best for you.

Fly from

Knoxville

Fly to

Durham

Route

Depart

Return

Price

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 11/20

6:00 am-12:08 pm

1 stop6h 08m

Raleigh-Durham

Sat 11/22

8:20 am-11:34 am

1 stop27h 14m

$213

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Wed 11/12

4:32 pm-7:32 pm

1 stop27h 00m

Raleigh-Durham

Sun 11/16

9:35 pm-1:57 pm

1 stop16h 22m

$240

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Wed 11/5

9:54 pm-11:58 am

1 stop14h 04m

Raleigh-Durham

Sun 11/9

9:35 pm-11:14 pm

1 stop25h 39m

$259

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Wed 12/10

6:09 pm-10:31 am

1 stop16h 22m

Raleigh-Durham

Sat 12/13

8:14 pm-12:32 pm

1 stop16h 18m

$290

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 12/5

7:59 pm-11:15 pm

1 stop3h 16m

Raleigh-Durham

Sun 12/7

5:15 am-9:38 am

1 stop4h 23m

$317

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Tue 12/9

5:40 am-8:57 am

1 stop3h 17m

Raleigh-Durham

Tue 12/9

2:12 pm-6:58 pm

1 stop4h 46m

$317

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Wed 11/26

7:00 am-5:47 pm

2 stops34h 47m

Raleigh-Durham

Wed 12/3

8:39 pm-11:53 am

1 stop15h 14m

$319

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Tue 11/25

5:28 pm-8:39 am

1 stop15h 11m

Raleigh-Durham

Sun 11/30

8:45 pm-10:40 pm

1 stop25h 55m

$326

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Wed 11/26

8:04 pm-12:04 am

1 stop4h 00m

Raleigh-Durham

Wed 12/3

6:00 am-11:32 am

1 stop5h 32m

$342

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Mon 11/17

3:53 pm-9:12 pm

1 stop5h 19m

Raleigh-Durham

Mon 11/24

5:41 pm-11:41 pm

1 stop6h 00m

$377

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 17 results
1
2

Best time to book a flight from Knoxville to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Durham

What is the cheapest month to book a flight from Knoxville to Durham?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Durham (average of $113). Flying from Knoxville to Durham in February is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to DU8?

Find hourly flight availability from Knoxville to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 38% on flights from Knoxville to Durham by exploring options for tickets at noon.

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated October 30, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Durham. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,998 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Durham?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Durham. You should not have trouble finding flights to Durham from McGhee Tyson; the airport handles an average of 0 outbound flights to Durham per day. You should also have plenty of airline options to choose from since 3 airlines have flights from the Knoxville airport to Durham. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • Can I find deals for flights from Knoxville to Durham that include hotel bookings?

    Yes. In addition to deals on Knoxville to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Durham.

  • Can I find deals for business class flights from Knoxville to Durham?

    Yes. Cheapflights offers flight deals from Knoxville to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Durham?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Durham (average of $113). Flying from Knoxville to Durham in February is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Durham

Discover the top 3 airlines that operate flights from Knoxville to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$354FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$328FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$233Average$346FlexibilityNo cancel feeOn-time69%

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