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$200+ Cheap flights from Knoxville (TYS) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RDU
May 5 — May 121
Mon 5/5
Mon 5/12
1 adult, Economy
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Cheap flight deals from Knoxville to Durham

Keep the following information in mind while searching for Knoxville to Durham flight deals. Data was last updated April 30, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$219
(American Airlines)

One-way from

$200
(American Airlines)

Popular in

June

Cheapest in

January

Average price

$323
Provider with most accurate pricing for Knoxville McGhee Tyson-Raleigh-Durham flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Raleigh-Durham flights.
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From Knoxville McGhee Tyson to Durham
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One-way flight from Knoxville McGhee Tyson to Durham
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Highest demand for flights based on searches. 19% potential increase in price ($77 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($22 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Knoxville to Durham

Cheapest flights from Knoxville to Durham
Explore the most affordable flight options available from Knoxville to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2025.

This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/137:54 pmTYS - RDU
1 stop4h 04mAmerican Airlines
Sat 5/1711:20 amRDU - TYS
1 stop6h 01mAmerican Airlines
Deal found 4/29$229
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/175:30 amTYS - RDU
1 stop4h 32mDelta
Sun 7/208:50 amRDU - TYS
1 stop6h 17mDelta
Deal found 4/29$239
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/145:02 pmTYS - RDU
2 stops21h 56mMultiple Airlines
Sun 5/183:55 pmRDU - TYS
2 stops20h 21mMultiple Airlines
Deal found 4/29$330
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/139:55 amTYS - RDU
1 stop4h 07mUnited Airlines
Sat 5/176:00 amRDU - TYS
2 stops17h 07mUnited Airlines
Deal found 4/29$398

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
Use the filters below to find and compare flights from Knoxville to Durham that are best for you.

Fly from

Knoxville

Fly to

Durham

Route

Depart

Return

Price

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 6/27

7:53 pm-11:59 pm

1 stop4h 06m

Raleigh-Durham

Mon 6/30

10:00 am-2:20 pm

1 stop4h 20m

$219

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Mon 5/26

5:45 am-8:50 am

1 stop3h 05m

Raleigh-Durham

Mon 6/2

5:25 am-9:40 am

1 stop4h 15m

$239

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Mon 5/12

7:15 am-2:58 pm

1 stop7h 43m

Raleigh-Durham

Thu 5/15

3:55 pm-12:16 pm

2 stops20h 21m

$263

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Tue 5/13

9:55 am-2:02 pm

1 stop4h 07m

Raleigh-Durham

Sat 5/17

6:00 am-11:07 pm

2 stops17h 07m

$398

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Sat 5/3

11:00 am-10:34 am

1 stop23h 34m

$226

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 5/2

6:05 pm-11:58 pm

1 stop5h 53m

$372

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Best time to book a flight from Knoxville to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Durham

What is the cheapest month to book a flight from Knoxville to Durham?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Durham (average of $206). Flying from Knoxville to Durham in March is currently the most expensive (average of $294). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to DU8?

Find hourly flight availability from Knoxville to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 30, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Durham as you normally would.

Rainfall in Durham by month

Plan your trip to Durham by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Durham ranges from 2.9 - 4.7 inches per month. July is typically the wettest month, when rainfall can reach 4.7 in. April is typically the driest time to visit Durham when rainfall is around 2.9 in.

Temperature in Durham by month

Plan your trip to Durham by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Durham, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated April 30, 2025.
Delta
8.0
Very good
7,936 reviews

Entertainment

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,936 reviews
Delta
8.0
Very good
7,936 reviews

Entertainment

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,936 reviews

Entertainment

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,936 reviews

Entertainment

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Durham?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Durham. You should not have trouble finding flights to Durham from McGhee Tyson; the airport handles an average of 0 outbound flights to Durham per day. You should also have plenty of airline options to choose from since 3 airlines have flights from the Knoxville airport to Durham. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • Can I find deals for flights from Knoxville to Durham that include hotel bookings?

    Yes. In addition to deals on Knoxville to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Durham.

  • Can I find deals for business class flights from Knoxville to Durham?

    Yes. Cheapflights offers flight deals from Knoxville to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Durham?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Durham (average of $206). Flying from Knoxville to Durham in March is currently the most expensive (average of $294). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Durham

Discover the top 3 airlines that operate flights from Knoxville to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$208Average$373FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$218Average$278FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$276FlexibilityNo cancel feeOn-time71%

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