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Durham

$119+ Cheap flights from Knoxville (TYS) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RDU
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Knoxville to Durham

Keep the following information in mind while searching for Knoxville to Durham flight deals. Data was last updated September 15, 2025.

Round-trip from

$228
(Kiwi.com)

One-way from

$119
(Kiwi.com)

Popular in

September

Cheapest in

November

Average price

$427
From Knoxville McGhee Tyson to Durham
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One-way flight from Knoxville McGhee Tyson to Durham
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Highest demand for flights based on searches. 4% potential increase in price ($15 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Durham

Cheapest flights from Knoxville to Durham
Explore the most affordable flight options available from Knoxville to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/248:40 amTYS - RDU
1 stop11h 59mMultiple Airlines
Mon 10/279:09 amRDU - TYS
1 stop25h 24mMultiple Airlines
Deal found 9/13$228
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/283:19 pmTYS - RDU
1 stop3h 53mMultiple Airlines
Thu 10/26:22 amRDU - TYS
2 stops10h 22mMultiple Airlines
Deal found 9/13$254
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/39:15 amTYS - RDU
1 stop11h 24mMultiple Airlines
Sat 11/86:00 amRDU - TYS
2 stops36h 22mMultiple Airlines
Deal found 9/13$270
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/217:35 pmTYS - RDU
1 stop18h 48mMultiple Airlines
Sun 9/288:57 pmRDU - TYS
1 stop20h 37mMultiple Airlines
Deal found 9/14$272
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/35:45 amTYS - RDU
1 stop3h 48mUnited Airlines
Sat 11/810:35 amRDU - TYS
1 stop4h 08mUnited Airlines
Deal found 9/13$317
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/186:19 pmTYS - RDU
1 stop23h 49mMultiple Airlines
Sat 9/2010:48 amRDU - TYS
1 stop9h 53mMultiple Airlines
Deal found 9/14$319
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/215:45 amTYS - RDU
1 stop3h 54mUnited Airlines
Mon 12/296:00 amRDU - TYS
1 stop4h 56mUnited Airlines
Deal found 9/14$332
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/272:50 pmTYS - RDU
1 stop4h 08mDelta
Mon 12/18:07 pmRDU - TYS
1 stop3h 45mDelta
Deal found 9/13$337
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/38:38 amTYS - RDU
1 stop12h 01mMultiple Airlines
Tue 10/73:57 pmRDU - TYS
1 stop27h 26mMultiple Airlines
Deal found 9/14$339

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Knoxville to Durham that are best for you.

Fly from

Knoxville

Fly to

Durham

Route

Depart

Return

Price

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 10/24

8:40 am-8:39 pm

1 stop11h 59m

Raleigh-Durham

Mon 10/27

9:09 am-10:33 am

1 stop25h 24m

$228

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Sun 9/28

3:19 pm-7:12 pm

1 stop3h 53m

Raleigh-Durham

Thu 10/2

6:22 am-4:44 pm

2 stops10h 22m

$254

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Mon 11/3

9:15 am-8:39 pm

1 stop11h 24m

Raleigh-Durham

Sat 11/8

6:00 am-6:22 pm

2 stops36h 22m

$270

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 11/27

5:25 am-10:00 am

1 stop4h 35m

Raleigh-Durham

Mon 12/1

8:07 pm-11:52 pm

1 stop3h 45m

$317

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Mon 12/22

5:45 am-9:39 am

1 stop3h 54m

Raleigh-Durham

Mon 12/29

6:00 am-10:56 am

1 stop4h 56m

$317

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Mon 11/3

5:45 am-9:33 am

1 stop3h 48m

Raleigh-Durham

Sat 11/8

10:35 am-2:43 pm

1 stop4h 08m

$317

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Sun 12/21

5:45 am-9:39 am

1 stop3h 54m

Raleigh-Durham

Mon 12/29

6:00 am-10:56 am

1 stop4h 56m

$332

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 10/3

8:38 am-8:39 pm

1 stop12h 01m

Raleigh-Durham

Tue 10/7

3:57 pm-7:23 pm

1 stop27h 26m

$339

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 11/14

6:42 pm-10:58 pm

2 stops28h 16m

$119

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Sat 9/20

8:55 pm-9:00 pm

2 stops24h 05m

$147

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 15 results
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Best time to book a flight from Knoxville to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Durham

What is the cheapest month to book a flight from Knoxville to Durham?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Durham (average of $206). Flying from Knoxville to Durham in March is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to DU8?

Find hourly flight availability from Knoxville to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Durham as you normally would.

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated September 15, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Durham. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,956 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,956 reviews
Delta
8.0
Very good
7,956 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,931 reviews
Delta
8.0
Very good
7,956 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,956 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Durham?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Durham. You should not have trouble finding flights to Durham from McGhee Tyson; the airport handles an average of 0 outbound flights to Durham per day. You should also have plenty of airline options to choose from since 3 airlines have flights from the Knoxville airport to Durham. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • Can I find deals for flights from Knoxville to Durham that include hotel bookings?

    Yes. In addition to deals on Knoxville to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Durham.

  • Can I find deals for business class flights from Knoxville to Durham?

    Yes. Cheapflights offers flight deals from Knoxville to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Durham?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Durham (average of $206). Flying from Knoxville to Durham in March is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Durham

Discover the top 3 airlines that operate flights from Knoxville to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$218Average$278FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$343FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$391FlexibilityNo cancel feeOn-timeN/A

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