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$131+ Cheap flights from Knoxville (TYS) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RDU
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
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Cheap flight deals from Knoxville to Durham

Cheapest flights from Knoxville to Durham
Explore the most affordable flight options available from Knoxville to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:00 amTYS - RDU
1 stop26h 14mMultiple Airlines
Fri 1/25:50 pmRDU - TYS
1 stop14h 28mMultiple Airlines
Deal found 12/13$313
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:33 pmTYS - RDU
1 stop22h 22mMultiple Airlines
Sat 1/311:51 amRDU - TYS
1 stop20h 27mMultiple Airlines
Deal found 12/15$334
This Kiwi.com deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2812:31 pmTYS - RDU
1 stop25h 10mMultiple Airlines
Fri 1/25:50 pmRDU - TYS
1 stop14h 28mMultiple Airlines
Deal found 12/12$363
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:38 pmTYS - RDU
1 stop15h 10mMultiple Airlines
Mon 12/228:14 pmRDU - TYS
2 stops44h 01mMultiple Airlines
Deal found 12/14$383
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:23 pmTYS - RDU
1 stop19h 32mMultiple Airlines
Sat 12/278:14 pmRDU - TYS
2 stops21h 33mMultiple Airlines
Deal found 12/15$409
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:23 pmTYS - RDU
1 stop19h 32mMultiple Airlines
Wed 12/247:20 pmRDU - TYS
1 stop16h 40mMultiple Airlines
Deal found 12/14$411
This Delta deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/204:31 pmTYS - RDU
1 stop4h 23mDelta
Sat 12/2712:51 pmRDU - TYS
1 stop6h 36mDelta
Deal found 12/15$449

Find flight deals from Knoxville to Durham

Keep the following information in mind while searching for Knoxville to Durham flight deals. Data was last updated December 15, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$225
(Kiwi.com)

One-way from

$131
(Kiwi.com)

Popular in

September

Cheapest in

June

Average price

$418
Provider with most accurate pricing for Knoxville McGhee Tyson-Raleigh-Durham flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Raleigh-Durham flights.
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From Knoxville McGhee Tyson to Durham
Search Deals
One-way flight from Knoxville McGhee Tyson to Durham
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($15 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Knoxville to Durham that are best for you.

Fly from

Knoxville

Fly to

Durham

Route

Depart

Return

Price

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Mon 3/16

7:50 am-1:20 pm

1 stop5h 30m

Raleigh-Durham

Mon 3/23

5:50 pm-10:10 pm

1 stop4h 20m

$317

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 2/6

6:41 pm-12:15 am

1 stop5h 34m

Raleigh-Durham

Sun 2/8

5:15 am-11:08 am

1 stop5h 53m

$317

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Tue 1/13

12:15 pm-4:24 pm

1 stop4h 09m

Raleigh-Durham

Wed 1/14

5:14 pm-10:54 pm

1 stop5h 40m

$337

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Sun 12/28

12:31 pm-1:41 pm

1 stop25h 10m

Raleigh-Durham

Fri 1/2

5:50 pm-8:18 am

1 stop14h 28m

$363

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Mon 12/29

6:00 am-4:55 pm

3 stops34h 55m

Raleigh-Durham

Fri 1/2

5:50 pm-8:18 am

1 stop14h 28m

$389

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Tue 12/30

6:33 pm-4:55 pm

1 stop22h 22m

Raleigh-Durham

Sat 1/3

2:06 pm-8:18 am

2 stops18h 12m

$401

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Sun 12/28

5:00 am-8:04 am

1 stop3h 04m

Raleigh-Durham

Fri 1/2

6:37 pm-9:58 pm

1 stop3h 21m

$478

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Mon 12/29

5:45 am-11:44 pm

1 stop17h 59m

Raleigh-Durham

Fri 1/2

7:40 pm-10:56 am

1 stop15h 16m

$537

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 2/6

6:45 am-6:52 pm

2 stops12h 07m

Raleigh-Durham

Sun 2/8

10:20 am-7:27 pm

1 stop9h 07m

$546

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Mon 12/22

5:38 pm-8:14 am

1 stop14h 36m

$131

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/13

Showing 1-10 of 11 results
1
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Best time to book a flight from Knoxville to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Durham

What is the cheapest month to book a flight from Knoxville to Durham?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Durham (average of $113). Flying from Knoxville to Durham in October is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to DU8?

Find hourly flight availability from Knoxville to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 15, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 38% on flights from Knoxville to Durham by exploring options for tickets at noon.

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated December 15, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Durham. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,092 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,052 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Durham?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Durham. You should not have trouble finding flights to Durham from McGhee Tyson; the airport handles an average of 0 outbound flights to Durham per day. You should also have plenty of airline options to choose from since 3 airlines have flights from the Knoxville airport to Durham. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Durham?

    Departing from Knoxville to Durham will take you 4h 09m. The distance between Knoxville and Durham is about 291 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Knoxville to Durham that include hotel bookings?

    Yes. In addition to deals on Knoxville to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Durham.

  • Can I find deals for business class flights from Knoxville to Durham?

    Yes. Cheapflights offers flight deals from Knoxville to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Durham?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Durham (average of $113). Flying from Knoxville to Durham in October is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Durham

Discover the top 3 airlines that operate flights from Knoxville to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$331FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$353FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$233Average$346FlexibilityNo cancel feeOn-time69%

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