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$92+ Cheap flights from Knoxville (TYS) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/9. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RDU
Apr 12 — Apr 191
Sun 4/12
Sun 4/19
1 adult, Economy
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Cheap flight deals from Knoxville to Durham

Cheapest flights from Knoxville to Durham
Explore the most affordable flight options available from Knoxville to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 13, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/171:15 pm
TYS
-
RDU
1 stop6h 43m
Multiple Airlines
Sun 4/1910:38 pm
RDU
-
TYS
1 stop23h 46m
Multiple Airlines
Deal found 3/9$226
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/811:26 am
TYS
-
RDU
1 stop25h 40m
Multiple Airlines
Wed 4/154:00 pm
RDU
-
TYS
2 stops23h 41m
Multiple Airlines
Deal found 3/11$236
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/72:56 pm
TYS
-
RDU
1 stop27h 48m
Multiple Airlines
Tue 4/147:46 pm
RDU
-
TYS
1 stop14h 50m
Multiple Airlines
Deal found 3/8$241
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:30 am
TYS
-
RDU
1 stop24h 30m
Multiple Airlines
Wed 4/87:46 pm
RDU
-
TYS
1 stop26h 19m
Multiple Airlines
Deal found 3/10$242
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:48 pm
TYS
-
RDU
1 stop18h 11m
Multiple Airlines
Fri 4/248:45 pm
RDU
-
TYS
1 stop21h 18m
Multiple Airlines
Deal found 3/11$260
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/267:30 am
TYS
-
RDU
1 stop7h 41m
Multiple Airlines
Sat 3/289:40 am
RDU
-
TYS
2 stops32h 09m
Multiple Airlines
Deal found 3/8$266
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:35 am
TYS
-
RDU
2 stops10h 40m
Southwest
Wed 4/89:50 am
RDU
-
TYS
2 stops9h 50m
Southwest
Deal found 3/10$273
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/211:03 pm
TYS
-
RDU
1 stop6h 37m
Multiple Airlines
Sun 5/249:02 pm
RDU
-
TYS
1 stop26h 35m
Multiple Airlines
Deal found 3/9$282

Find flight deals from Knoxville to Durham

Keep the following information in mind while searching for Knoxville to Durham flight deals. Data was last updated March 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$226
(Kiwi.com)

One-way from

$92
(Kiwi.com)

Popular in

February

Cheapest in

June

Average price

$342
Provider with most accurate pricing for Knoxville McGhee Tyson-Raleigh-Durham flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Raleigh-Durham flights.
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From Knoxville McGhee Tyson to Durham
Search Deals
One-way flight from Knoxville McGhee Tyson to Durham
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($147 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($36 potential savings vs. average RT price).
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Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
Use the filters below to find and compare flights from Knoxville to Durham that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 3/26

7:30 am-3:11 pm

1 stop7h 41m

Raleigh-Durham

Sat 3/28

9:40 am-5:49 pm

2 stops32h 09m

$266

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Wed 4/8

7:05 am-4:30 pm

2 stops9h 25m

Raleigh-Durham

Wed 4/15

9:50 am-7:40 pm

2 stops9h 50m

$273

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Wed 4/1

6:35 am-5:15 pm

2 stops10h 40m

Raleigh-Durham

Wed 4/8

9:50 am-7:40 pm

2 stops9h 50m

$273

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Wed 4/8

7:05 am-12:45 pm

1 stop5h 40m

Raleigh-Durham

Fri 4/10

4:25 pm-8:20 pm

1 stop3h 55m

$300

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 4/17

1:15 pm-7:58 pm

1 stop6h 43m

Raleigh-Durham

Sun 4/19

6:10 am-9:57 pm

2 stops15h 47m

$304
Quickest round-trip

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 4/17

6:45 pm-10:15 pm

1 stop3h 30m

Raleigh-Durham

Sun 4/19

6:15 am-11:40 am

1 stop5h 25m

$317

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Sat 5/23

6:40 am-6:35 pm

2 stops11h 55m

Raleigh-Durham

Mon 5/25

4:50 pm-9:15 pm

1 stop4h 25m

$324

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 5/21

6:35 am-5:30 pm

2 stops10h 55m

Raleigh-Durham

Sun 5/24

4:45 pm-8:45 pm

1 stop4h 00m

$332

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 3/27

2:06 pm-9:53 pm

1 stop7h 47m

Raleigh-Durham

Sun 3/29

4:07 pm-8:08 am

2 stops16h 01m

$365

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 3/26

6:30 am-12:10 pm

1 stop5h 40m

Raleigh-Durham

Sat 3/28

5:30 pm-10:10 pm

1 stop4h 40m

$417

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/11

Showing 1-10 of 22 resultsSorted by cheapest first
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Best time to book a flight from Knoxville to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Durham

What is the cheapest month to book a flight from Knoxville to Durham?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Durham (average of $113). Flying from Knoxville to Durham in October is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated March 13, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Knoxville to Durham. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,285 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,285 reviews
Delta
7.9
Good
8,285 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,418 reviews
Delta
7.9
Good
8,285 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,446 reviews
Delta
7.9
Good
8,285 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Durham?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Durham. You should not have trouble finding flights to Durham from McGhee Tyson; the airport handles an average of 0 outbound flights to Durham per day. You should also have plenty of airline options to choose from since 3 airlines have flights from the Knoxville airport to Durham. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Durham?

    Departing from Knoxville to Durham will take you 9h 25m. The distance between Knoxville and Durham is about 291 mi.

  • Can I find deals for flights from Knoxville to Durham that include hotel bookings?

    Yes. In addition to deals on Knoxville to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Durham.

  • Can I find deals for business class flights from Knoxville to Durham?

    Yes. Cheapflights offers flight deals from Knoxville to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Durham?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Durham (average of $113). Flying from Knoxville to Durham in October is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Knoxville to Durham

Discover the top 3 airlines that operate flights from Knoxville to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$330FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$381FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$233Average$346FlexibilityNo cancel feeOn-time69%

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