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$149+ Cheap flights from Knoxville (TYS) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/21. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RDU
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Knoxville to Durham

Keep the following information in mind while searching for Knoxville to Durham flight deals. Data was last updated June 12, 2025.

Round-trip from

$204
(Mytrip)

One-way from

$149
(Mytrip)

Popular in

February

Cheapest in

January

Average price

$331
From Knoxville McGhee Tyson to Durham
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One-way flight from Knoxville McGhee Tyson to Durham
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Highest demand for flights based on searches. 4% potential increase in price ($13 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Knoxville to Durham

Cheapest flights from Knoxville to Durham
Explore the most affordable flight options available from Knoxville to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Mytrip deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/28:30 amTYS - RDU
1 stop25h 10mMultiple Airlines
Thu 7/33:22 pmRDU - TYS
1 stop25h 25mMultiple Airlines
Deal found 6/12$204
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/175:30 amTYS - RDU
1 stop4h 32mDelta
Sun 7/208:15 pmRDU - TYS
1 stop3h 44mDelta
Deal found 6/11$219
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/267:53 pmTYS - RDU
1 stop4h 06mAmerican Airlines
Mon 6/302:50 pmRDU - TYS
1 stop4h 11mAmerican Airlines
Deal found 6/11$229
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/119:55 amTYS - RDU
1 stop6h 49mUnited Airlines
Wed 6/186:00 amRDU - TYS
1 stop4h 27mUnited Airlines
Deal found 6/10$249

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Knoxville to Durham that are best for you.

Fly from

Knoxville

Fly to

Durham

Route

Depart

Return

Price

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Wed 7/2

8:30 am-9:40 am

1 stop25h 10m

Raleigh-Durham

Thu 7/3

3:22 pm-4:47 pm

1 stop25h 25m

$204

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 7/17

5:30 am-10:02 am

1 stop4h 32m

Raleigh-Durham

Sun 7/20

8:15 pm-11:59 pm

1 stop3h 44m

$219

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 6/26

7:53 pm-11:59 pm

1 stop4h 06m

Raleigh-Durham

Mon 6/30

2:50 pm-7:01 pm

1 stop4h 11m

$229

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 6/26

5:45 am-9:28 am

1 stop3h 43m

Raleigh-Durham

Mon 6/30

5:16 pm-10:35 pm

1 stop5h 19m

$289

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Sat 6/21

8:10 am-6:21 pm

1 stop10h 11m

$149

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 9/4

8:26 pm-4:30 pm

1 stop20h 04m

$156

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 9/4

9:55 am-9:58 pm

2 stops12h 03m

$363

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Knoxville to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Durham

What is the cheapest month to book a flight from Knoxville to Durham?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Durham (average of $206). Flying from Knoxville to Durham in March is currently the most expensive (average of $294). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to DU8?

Find hourly flight availability from Knoxville to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Durham as you normally would.

Rainfall in Durham by month

Plan your trip to Durham by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Durham ranges from 2.9 - 4.7 inches per month. July is typically the wettest month, when rainfall can reach 4.7 in. April is typically the driest time to visit Durham when rainfall is around 2.9 in.

Temperature in Durham by month

Plan your trip to Durham by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Durham, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated June 12, 2025.
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,950 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Frontier
5.9
Fair
3,295 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Durham?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Durham. You should not have trouble finding flights to Durham from McGhee Tyson; the airport handles an average of 0 outbound flights to Durham per day. You should also have plenty of airline options to choose from since 3 airlines have flights from the Knoxville airport to Durham. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • Can I find deals for flights from Knoxville to Durham that include hotel bookings?

    Yes. In addition to deals on Knoxville to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Durham.

  • Can I find deals for business class flights from Knoxville to Durham?

    Yes. Cheapflights offers flight deals from Knoxville to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Durham?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Durham (average of $206). Flying from Knoxville to Durham in March is currently the most expensive (average of $294). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Durham

Discover the top 3 airlines that operate flights from Knoxville to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$208Average$333FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$218Average$278FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$287FlexibilityNo cancel feeOn-time71%

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