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$152+ Cheap flights from Knoxville (TYS) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/14. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RDU
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
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Cheap flight deals from Knoxville to Durham

Keep the following information in mind while searching for Knoxville to Durham flight deals. Data was last updated July 31, 2025.

Round-trip from

$219
(Delta)

One-way from

$189
(United Airlines)

Popular in

February

Cheapest in

January

Average price

$298
From Knoxville McGhee Tyson to Durham
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One-way flight from Knoxville McGhee Tyson to Durham
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Highest demand for flights based on searches. 6% potential increase in price ($20 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Knoxville to Durham

Cheapest flights from Knoxville to Durham
Explore the most affordable flight options available from Knoxville to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/186:08 pmTYS - RDU
1 stop6h 05mDelta
Sun 9/218:50 amRDU - TYS
1 stop4h 17mDelta
Deal found 7/30$219
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/83:41 pmTYS - RDU
1 stop2h 57mAmerican Airlines
Fri 8/223:46 pmRDU - TYS
1 stop3h 08mAmerican Airlines
Deal found 7/29$229
This Mytrip deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:38 pmTYS - RDU
2 stops19h 41mMultiple Airlines
Mon 11/172:14 pmRDU - TYS
2 stops20h 20mMultiple Airlines
Deal found 7/31$286
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/129:55 amTYS - RDU
1 stop4h 18mUnited Airlines
Tue 8/195:35 pmRDU - TYS
1 stop5h 02mUnited Airlines
Deal found 7/30$294

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Knoxville to Durham that are best for you.

Fly from

Knoxville

Fly to

Durham

Route

Depart

Return

Price

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 9/18

6:08 pm-12:13 am

1 stop6h 05m

Raleigh-Durham

Sun 9/21

8:50 am-1:07 pm

1 stop4h 17m

$219

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 8/8

3:41 pm-6:38 pm

1 stop2h 57m

Raleigh-Durham

Fri 8/22

3:46 pm-6:54 pm

1 stop3h 08m

$229

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Tue 8/12

9:55 am-2:13 pm

1 stop4h 18m

Raleigh-Durham

Tue 8/19

5:35 pm-10:37 pm

1 stop5h 02m

$294

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 9/4

7:35 pm-3:52 pm

2 stops20h 17m

Raleigh-Durham

Sun 9/7

9:49 pm-11:55 am

1 stop14h 06m

$317

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 8/14

8:52 pm-1:47 pm

2 stops16h 55m

$152

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Tue 9/9

2:30 pm-6:40 pm

1 stop4h 10m

$189

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Sun 9/14

5:45 am-8:51 am

1 stop3h 06m

$220

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 8/14

5:06 am-9:04 am

1 stop3h 58m

$265

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/31

Best time to book a flight from Knoxville to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Durham

What is the cheapest month to book a flight from Knoxville to Durham?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Durham (average of $206). Flying from Knoxville to Durham in March is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to DU8?

Find hourly flight availability from Knoxville to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Durham as you normally would.

How much does it cost to fly round-trip from Knoxville to Durham?

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated July 31, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Durham. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,900 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Durham?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Durham. You should not have trouble finding flights to Durham from McGhee Tyson; the airport handles an average of 0 outbound flights to Durham per day. You should also have plenty of airline options to choose from since 3 airlines have flights from the Knoxville airport to Durham. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • Can I find deals for flights from Knoxville to Durham that include hotel bookings?

    Yes. In addition to deals on Knoxville to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Durham.

  • Can I find deals for business class flights from Knoxville to Durham?

    Yes. Cheapflights offers flight deals from Knoxville to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Durham?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Durham (average of $206). Flying from Knoxville to Durham in March is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Durham

Discover the top 3 airlines that operate flights from Knoxville to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$218Average$278FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$218Average$322FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$333FlexibilityNo cancel feeOn-timeN/A

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