How popular is this Portland to Des Moines flight route?

The Portland to Des Moines flight path was viewed by 9 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

How long is the flight from Portland to Des Moines?

Departing from Portland to Des Moines will take you 8h 20m. Portland and Des Moines are separated by a distance of 1466 mi. This flight may include one or multiple stops.

What are the cheapest airlines flying from Portland to Des Moines round-trip?

According to our current data, Allegiant Air ($114), Frontier ($150), and American Airlines ($261) offers the cheapest pricing from Portland to Des Moines. These flights start at 66% lower than the current average price 3 months from now.

What are the cheapest airlines to fly from Portland to Des Moines one-way?

One-way options have recently been found by users for as low as $104 on Frontier. Other airlines that offer cheap prices include Delta from $131 and American Airlines from $131 one-way.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

What are the cheapest flights from Portland to Des Moines?

On average you can expect to pay $177 for a flight from Portland to Des Moines. The cheapest flight overall is $97 while the most popular route, (Portland - Des Moines) is currently priced at $291.

What are the most popular airlines that fly from Portland to Des Moines?

Before booking your flight from Portland to Des Moines check out the most popular airlines for this route: Allegiant Air, United Airlines or American Airlines.

Most accurate provider : When it comes to deals on Portland-Des Moines flights, users find the pricing of Gotogate to be most consistent on Cheapflights vs. Gotogate Users can find the same prices on Portland-Des Moines flight deals on Cheapflights vs. Gotogate >95% of the time. Price accuracy is based on data collected from Portland-Des Moines flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Portland-Des Moines flights, Cheapflights users trust Gotogate the most. Gotogate has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Portland to Des Moines that include hotel bookings?

Yes. In addition to deals on Portland to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Portland to Des Moines?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Des Moines.

Can I find deals for business class flights from Portland to Des Moines?

Yes. Cheapflights offers flight deals from Portland to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$104+ Flights from Portland to Des Moines

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

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Cheapflights Tip: The best prices from Portland to Des Moines are usually found in September or August, booked 68 days in advance, depart on a Tuesday or Monday and return on a Saturday

Find flight deals from Portland to Des Moines

Cheapest flights from Portland to Des Moines
Explore the most affordable flight options available from Portland to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

Thu 11/1312:52 pmPDX - DSM

1 stop22h 57mFrontier

Mon 11/172:32 pmDSM - PDX

1 stop23h 24mFrontier

Deal found 10/28

$150

Thu 11/1312:52 pmPDX - DSM

2 stops31h 48mMultiple Airlines

Mon 11/172:32 pmDSM - PDX

1 stop23h 24mMultiple Airlines

Deal found 10/28

$272

Thu 12/189:44 pmPDX - DSM

1 stop19h 20mMultiple Airlines

Wed 12/313:00 pmDSM - PDX

1 stop24h 24mMultiple Airlines

Deal found 10/28

$285

Sun 12/1412:51 pmPDX - DSM

1 stop28h 12mMultiple Airlines

Wed 12/313:00 pmDSM - PDX

1 stop24h 24mMultiple Airlines

Deal found 10/28

$298

Mon 12/83:15 pmPDX - DSM

1 stop6h 37mAmerican Airlines

Tue 12/95:40 amDSM - PDX

1 stop7h 07mAmerican Airlines

Deal found 10/29

$302

Fri 12/198:45 pmPDX - DSM

2 stops20h 59mMultiple Airlines

Wed 12/313:00 pmDSM - PDX

1 stop24h 24mMultiple Airlines

Deal found 10/28

$307

Thu 12/189:44 pmPDX - DSM

1 stop19h 20mMultiple Airlines

Tue 12/302:35 pmDSM - PDX

2 stops26h 25mMultiple Airlines

Deal found 10/28

$314

Sun 12/1412:51 pmPDX - DSM

1 stop28h 12mFrontier

Tue 12/302:35 pmDSM - PDX

2 stops26h 25mFrontier

Deal found 10/28

$320

Thu 12/189:44 pmPDX - DSM

2 stops20h 00mFrontier

Fri 1/28:29 pmDSM - PDX

1 stop17h 23mFrontier

Deal found 10/28

$335

Sun 12/1412:51 pmPDX - DSM

1 stop28h 12mFrontier

Fri 1/28:29 pmDSM - PDX

1 stop17h 23mFrontier

Deal found 10/28

$339

Best flights from Portland to Des Moines
Discover carefully curated flight deals from Portland to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2025.

Thu 11/1312:52 pmPDX - DSM

2 stops31h 48mMultiple Airlines

Mon 11/172:32 pmDSM - PDX

1 stop23h 24mMultiple Airlines

Deal found 10/28

$272

Sat 1/171:24 pmPDX - DSM

1 stop8h 20mUnited Airlines

Tue 1/203:04 pmDSM - PDX

1 stop9h 49mUnited Airlines

Deal found 10/29

$291

Mon 12/87:15 amPDX - DSM

2 stops10h 40mSouthwest

Tue 12/912:05 pmDSM - PDX

2 stops11h 20mSouthwest

Deal found 10/29

$353

Tue 11/2512:35 amPDX - DSM

1 stop7h 45mDelta

Wed 12/34:59 pmDSM - PDX

1 stop5h 53mDelta

Deal found 10/30

$400

Tue 12/24:02 pmPDX - DSM

1 stop5h 42mUnited Airlines

Fri 12/511:35 amDSM - PDX

2 stops11h 40mUnited Airlines

Deal found 10/29

$397

Mon 12/87:15 amPDX - DSM

2 stops10h 40mSouthwest

Thu 12/1112:05 pmDSM - PDX

2 stops11h 20mSouthwest

Deal found 10/28

$405

Fri 12/1212:32 amPDX - DSM

1 stop7h 49mDelta

Wed 12/3112:10 pmDSM - PDX

2 stops12h 43mDelta

Deal found 10/28

$417

Thu 11/277:05 amPDX - DSM

1 stop4h 50mSouthwest

Thu 12/48:20 amDSM - PDX

1 stop7h 10mSouthwest

Deal found 10/30

$405

Wed 11/2612:55 pmPDX - DSM

1 stop5h 50mUnited Airlines

Wed 12/35:45 amDSM - PDX

2 stops11h 02mUnited Airlines

Deal found 10/30

$410

Wed 12/1711:20 pmPDX - DSM

1 stop8h 25mDelta

Wed 12/3112:10 pmDSM - PDX

2 stops12h 43mDelta

Deal found 10/28

$417

Last-minute flights from Portland to Des Moines
Discover last-minute flight deals from Portland to Des Moines. Data last updated October 30, 2025 and is based on user searches.

Sat 11/112:52 pmPDX - DSM

1 stop23h 55mFrontier

Mon 11/32:32 pmDSM - PDX

1 stop23h 24mFrontier

Deal found 10/28

$285

Thu 11/612:52 pmPDX - DSM

1 stop22h 55mMultiple Airlines

Sun 11/92:17 pmDSM - PDX

2 stops26h 14mMultiple Airlines

Deal found 10/29

$416

Thu 11/1312:52 pmPDX - DSM

1 stop22h 57mFrontier

Mon 11/172:32 pmDSM - PDX

1 stop23h 24mFrontier

Deal found 10/28

$150

Thu 11/1312:52 pmPDX - DSM

2 stops31h 48mMultiple Airlines

Mon 11/172:32 pmDSM - PDX

1 stop23h 24mMultiple Airlines

Deal found 10/28

$272

Sun 11/235:30 amPDX - DSM

1 stop9h 11mAmerican Airlines

Mon 12/15:26 pmDSM - PDX

1 stop7h 33mAmerican Airlines

Deal found 10/27

$447

Tue 11/2512:35 amPDX - DSM

1 stop7h 45mDelta

Wed 12/34:59 pmDSM - PDX

1 stop5h 53mDelta

Deal found 10/30

$400

Tue 11/252:31 pmPDX - DSM

1 stop20h 44mMultiple Airlines

Sun 11/308:19 pmDSM - PDX

2 stops41h 16mMultiple Airlines

Deal found 10/29

$410

Tue 11/252:31 pmPDX - DSM

1 stop20h 44mFrontier

Sun 11/308:19 pmDSM - PDX

1 stop20h 57mFrontier

Deal found 10/29

$431

Wed 11/263:15 pmPDX - DSM

1 stop6h 39mAmerican Airlines

Wed 12/33:38 pmDSM - PDX

1 stop7h 46mAmerican Airlines

Deal found 10/30

$364

Wed 11/2612:15 pmPDX - DSM

2 stops9h 50mSouthwest

Wed 12/312:05 pmDSM - PDX

2 stops11h 20mSouthwest

Deal found 10/30

$425

Thu 11/277:05 amPDX - DSM

1 stop4h 50mSouthwest

Thu 12/48:20 amDSM - PDX

1 stop7h 10mSouthwest

Deal found 10/30

$405

One-way flights from Portland to Des Moines
Search for one-way flight options from Portland to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 30, 2025.

Sun 12/712:51 pmPDX - DSM

1 stop28h 12mFrontier

Deal found 10/29

$104

Tue 12/212:32 amPDX - DSM

1 stop7h 49mDelta

Deal found 10/29

$131

Tue 11/252:31 pmPDX - DSM

1 stop20h 44mFrontier

Deal found 10/28

$138

Sat 1/312:37 pmPDX - DSM

1 stop5h 07mFrontier

Deal found 10/29

$141

Wed 12/38:30 amPDX - DSM

2 stops11h 07mUnited Airlines

Deal found 10/29

$177

Wed 11/268:59 amPDX - DSM

1 stop27h 24mMultiple Airlines

Deal found 10/28

$181

Sat 1/35:39 pmPDX - DSM

3 stops48h 05mMultiple Airlines

Deal found 10/29

$184

Fri 1/26:14 pmPDX - DSM

2 stops23h 30mMultiple Airlines

Deal found 10/29

$206

Sat 12/612:32 amPDX - DSM

1 stop7h 49mDelta

Deal found 10/29

$214

Sun 12/710:50 amPDX - DSM

2 stops8h 10mSouthwest

Deal found 10/29

$219

Cheap flight deals from Portland to Des Moines

Most accurate provider	Gotogate 3 stars
Most trusted provider	Gotogate 3 stars
Round-trip from	$150 (Mytrip)
One-way from	$104 (Booking.com)
Popular in	December
Cheapest in	September
Average price	$288
Good one-way deal	$107 or less

Provider with most accurate pricing for Portland-Des Moines flight deals.

Search Deals

Provider most trusted by Cheapflights users for Portland-Des Moines flights.

Search Deals

From Portland to Des Moines

Search Deals

One-way flight from Portland to Des Moines

Search Deals

Highest demand for flights based on searches. 25% potential increase in price ($117 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in October 2025

Search Deals

Price to beat on a one-way flight from Portland to Des Moines.

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Portland to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PortlandDes Moines

PDX - DSM

PDXDSM

Portland

Thu 11/13

12:52 pm-10:40 pm

2 stops31h 48m

Des Moines

Mon 11/17

2:32 pm-11:56 am

1 stop23h 24m

$272

PortlandDes Moines

PDX - DSM

PDXDSM

Portland

Sat 1/17

1:24 pm-11:44 pm

1 stop8h 20m

Des Moines

Tue 1/20

3:04 pm-10:53 pm

1 stop9h 49m

$291

PortlandDes Moines

PDX - DSM

PDXDSM

Portland

Mon 12/8

7:15 am-7:55 pm

2 stops10h 40m

Des Moines

Tue 12/9

12:05 pm-9:25 pm

2 stops11h 20m

$353

PortlandDes Moines

PDX - DSM

PDXDSM

Portland

Tue 12/2

4:02 pm-11:44 pm

1 stop5h 42m

Des Moines

Fri 12/5

11:35 am-9:15 pm

2 stops11h 40m

$397

PortlandDes Moines

PDX - DSM

PDXDSM

Portland

Tue 11/25

12:35 am-10:20 am

1 stop7h 45m

Des Moines

Wed 12/3

4:59 pm-8:52 pm

1 stop5h 53m

$400

PortlandDes Moines

PDX - DSM

PDXDSM

Portland

Mon 12/8

7:15 am-7:55 pm

2 stops10h 40m

Des Moines

Thu 12/11

12:05 pm-9:25 pm

2 stops11h 20m

$405

PortlandDes Moines

PDX - DSM

PDXDSM

Portland

Thu 11/27

7:05 am-1:55 pm

1 stop4h 50m

Des Moines

Thu 12/4

8:20 am-1:30 pm

1 stop7h 10m

$405

PortlandDes Moines

PDX - DSM

PDXDSM

Portland

Wed 11/26

12:55 pm-8:45 pm

1 stop5h 50m

Des Moines

Wed 12/3

5:45 am-2:47 pm

2 stops11h 02m

$410

PortlandDes Moines

PDX - DSM

PDXDSM

Portland

Fri 12/12

12:32 am-10:21 am

1 stop7h 49m

Des Moines

Wed 12/31

12:10 pm-10:53 pm

2 stops12h 43m

$417

PortlandDes Moines

PDX - DSM

PDXDSM

Portland

Wed 12/17

11:20 pm-9:45 am

1 stop8h 25m

Des Moines

Wed 12/31

12:10 pm-10:53 pm

2 stops12h 43m

$417

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 20 results

Compare providers for flights from Portland to Des Moines

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Portland to Des Moines in October.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Cheapflightsfares	Price Accuracy3 stars	Trust Score*2 stars
Gotogate	Price Accuracy3 stars	Trust Score*3 stars
Priceline	Price Accuracy1 star	Trust Score*3 stars
JustAirTicket	Price Accuracy-	Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Portland-Des Moines flights, users find the pricing of Gotogate to be most consistent on Cheapflights vs. Gotogate Users can find the same prices on Portland-Des Moines flight deals on Cheapflights vs. Gotogate >95% of the time. Price accuracy is based on data collected from Portland-Des Moines flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Portland-Des Moines flights, Cheapflights users trust Gotogate the most. Gotogate has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Portland to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Portland with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Des Moines

How far ahead should I book a flight from Portland to Des Moines?

The price you pay for your flight from Portland to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 67 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Portland to Des Moines?

Currently, September is the cheapest month in which you can book a flight from Portland to Des Moines (average of $71). Flying from Portland to Des Moines in December is currently the most expensive (average of $254). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PDX to DSM?

When flying from Portland to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 61% versus a flight in the evening.

What is the cheapest day to fly from Portland to Des Moines?

Travelers seeking maximum savings on their Portland to Des Moines flight should consider departing on Tuesday at noon when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Des Moines

See what other customers who have flown with Delta, United Airlines, and American Airlines from Portland to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

7,993 reviews

Reviews

1 / 20

8.0

Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Delta

7.9

Good

7,993 reviews

Delta

7.9

Good

7,993 reviews

Reviews

1 / 20

8.0

Excellent

Matthew,Oct 2025

GSP - ATL

United Airlines

7.4

Good

8,998 reviews

Delta

7.9

Good

7,993 reviews

Reviews

1 / 20

8.0

Excellent

Matthew,Oct 2025

GSP - ATL

American Airlines

7.2

Good

11,030 reviews

Delta

7.9

Good

7,993 reviews

Reviews

1 / 20

8.0

Excellent

Matthew,Oct 2025

GSP - ATL

Allegiant Air

7.2

Good

695 reviews

Delta

7.9

Good

7,993 reviews

Reviews

1 / 20

8.0

Excellent

Matthew,Oct 2025

GSP - ATL

Frontier

5.8

Fair

3,123 reviews

Delta

7.9

Good

7,993 reviews

Reviews

1 / 20

8.0

Excellent

Matthew,Oct 2025

GSP - ATL

Related info for your journey

How popular is this Portland to Des Moines flight route?
The Portland to Des Moines flight path was viewed by 9 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Portland to Des Moines?
Departing from Portland to Des Moines will take you 8h 20m. Portland and Des Moines are separated by a distance of 1466 mi. This flight may include one or multiple stops.
What are the cheapest airlines flying from Portland to Des Moines round-trip?
According to our current data, Allegiant Air ($114), Frontier ($150), and American Airlines ($261) offers the cheapest pricing from Portland to Des Moines. These flights start at 66% lower than the current average price 3 months from now.
What are the cheapest airlines to fly from Portland to Des Moines one-way?
One-way options have recently been found by users for as low as $104 on Frontier. Other airlines that offer cheap prices include Delta from $131 and American Airlines from $131 one-way.
What are the cheapest flights from Portland to Des Moines?
On average you can expect to pay $177 for a flight from Portland to Des Moines. The cheapest flight overall is $97 while the most popular route, (Portland - Des Moines) is currently priced at $291.
Can I find deals for flights from Portland to Des Moines that include hotel bookings?
Yes. In addition to deals on Portland to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Portland to Des Moines?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Des Moines.
Can I find deals for business class flights from Portland to Des Moines?
Yes. Cheapflights offers flight deals from Portland to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Portland to Des Moines?
Currently, September is the cheapest month in which you can book a flight from Portland to Des Moines (average of $71). Flying from Portland to Des Moines in December is currently the most expensive (average of $254). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Johnston

Altoona

Boone

Ames

West Des Moines

Ankeny

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Alternative routes for Portland to Des Moines

Other flights to Des Moines

Top 6 airlines flying from Portland to Des Moines

Airline	Cheapest	Average	Flexibility	On-time
Allegiant Air	Cheapest$114	Average$198	FlexibilityNo cancel fee	On-time88%
Frontier	Cheapest$150	Average$242	FlexibilityNo cancel fee	On-time62%
American Airlines	Cheapest$261	Average$406	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$269	Average$481	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$282	Average$442	FlexibilityNo cancel fee	On-timeN/A
Southwest	Cheapest$364	Average$486	FlexibilityNo cancel fee	On-time63%

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$104+ Cheap flights from Portland to Des Moines (PDX - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Portland to Des Moines with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Portland to Des Moines are usually found in September or August, booked 68 days in advance, depart on a Tuesday or Monday and return on a Saturday

Find flight deals from Portland to Des Moines

Cheapest flights from Portland to Des MoinesExplore the most affordable flight options available from Portland to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

Explore the most affordable flight options available from Portland to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

Cheap flight deals from Portland to Des Moines

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good one-way deal

Cheapflights Fare Finder

Use the filters below to find and compare flights from Portland to Des Moines that are best for you.

Compare providers for flights from Portland to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Portland to Des Moines in October.

Best time to book a flight from Portland to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Portland with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Portland to Des Moines

How far ahead should I book a flight from Portland to Des Moines?

What is the cheapest month to book a flight from Portland to Des Moines?

What is the cheapest time of day to fly from PDX to DSM?

What is the cheapest day to fly from Portland to Des Moines?

Reviews of airlines servicing Des Moines

See what other customers who have flown with Delta, United Airlines, and American Airlines from Portland to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Portland to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How popular is this Portland to Des Moines flight route?

How long is the flight from Portland to Des Moines?

What are the cheapest airlines flying from Portland to Des Moines round-trip?

What are the cheapest airlines to fly from Portland to Des Moines one-way?

What are the cheapest flights from Portland to Des Moines?

Can I find deals for flights from Portland to Des Moines that include hotel bookings?

How can I find direct flights from Portland to Des Moines?

Can I find deals for business class flights from Portland to Des Moines?

What is the cheapest month to book a flight from Portland to Des Moines?

Traveling to a place near Des Moines?

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Alternative routes for Portland to Des Moines

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Top 6 airlines flying from Portland to Des Moines

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Cheapest flights from Portland to Des Moines
Explore the most affordable flight options available from Portland to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.