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Des Moines

$126+ Cheap flights from Milwaukee to Des Moines (MKE - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/28. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — DSM
Apr 4 — Apr 111
Sat 4/4
Sat 4/11
1 adult, Economy
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Cheap flight deals from Milwaukee to Des Moines

Cheapest flights from Milwaukee to Des Moines
Explore the most affordable flight options available from Milwaukee to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 5, 2026.

This Frontier deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/168:20 pm
MKE
-
DSM
1 stop13h 25m
Frontier
Fri 3/2010:15 am
DSM
-
MKE
1 stop9h 51m
Frontier
Deal found 3/1$250
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/109:08 am
MKE
-
DSM
1 stop4h 38m
American Airlines
Sun 4/125:01 pm
DSM
-
MKE
1 stop4h 59m
American Airlines
Deal found 3/2$277
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/164:50 pm
MKE
-
DSM
1 stop6h 15m
Southwest
Sun 4/194:20 pm
DSM
-
MKE
2 stops7h 35m
Southwest
Deal found 3/3$284
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:40 am
MKE
-
DSM
1 stop5h 10m
Southwest
Fri 8/145:40 am
DSM
-
MKE
1 stop5h 20m
Southwest
Deal found 3/1$287
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:11 am
MKE
-
DSM
1 stop3h 19m
American Airlines
Sun 4/1911:09 am
DSM
-
MKE
1 stop4h 47m
American Airlines
Deal found 3/3$293
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:40 am
MKE
-
DSM
1 stop5h 10m
Southwest
Sat 8/1512:10 pm
DSM
-
MKE
2 stops6h 15m
Southwest
Deal found 3/1$302
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/712:00 pm
MKE
-
DSM
1 stop5h 09m
Delta
Thu 7/97:00 am
DSM
-
MKE
1 stop4h 11m
Delta
Deal found 3/3$307
This United Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:10 am
MKE
-
DSM
1 stop5h 27m
United Airlines
Wed 5/62:58 pm
DSM
-
MKE
1 stop8h 01m
United Airlines
Deal found 3/4$314

Find flight deals from Milwaukee to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Milwaukee (MKE) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 5, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$250
(Frontier)

One-way from

$126
(American Airlines)
Provider with most accurate pricing for Milwaukee-Mitchell-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Milwaukee-Mitchell-Des Moines flights.
Search Deals
From Milwaukee-Mitchell to Des Moines
Search Deals
One-way flight from Milwaukee-Mitchell to Des Moines
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Milwaukee to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 5, 2026.
Use the filters below to find and compare flights from Milwaukee to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MilwaukeeDes Moines

MKE - DSM

MKEDSM

Milwaukee-Mitchell

Mon 3/16

8:20 pm-9:45 am

1 stop13h 25m

Des Moines

Fri 3/20

10:15 am-8:06 pm

1 stop9h 51m

$250

MilwaukeeDes Moines

MKE - DSM

MKEDSM

Milwaukee-Mitchell

Tue 8/11

6:00 am-10:11 am

1 stop4h 11m

Des Moines

Sat 8/15

5:00 am-11:35 am

1 stop6h 35m

$287
Quickest round-trip

MilwaukeeDes Moines

MKE - DSM

MKEDSM

Milwaukee-Mitchell

Tue 8/11

6:40 am-11:50 am

1 stop5h 10m

Des Moines

Fri 8/14

5:40 am-11:00 am

1 stop5h 20m

$287

MilwaukeeDes Moines

MKE - DSM

MKEDSM

Milwaukee-Mitchell

Thu 4/16

8:00 am-11:05 pm

2 stops15h 05m

Des Moines

Sun 4/19

5:20 am-12:45 pm

2 stops7h 25m

$295

MilwaukeeDes Moines

MKE - DSM

MKEDSM

Milwaukee-Mitchell

Tue 8/11

6:40 am-11:50 am

1 stop5h 10m

Des Moines

Sat 8/15

12:10 pm-6:25 pm

2 stops6h 15m

$302

MilwaukeeDes Moines

MKE - DSM

MKEDSM

Milwaukee-Mitchell

Sat 5/2

5:10 am-10:37 am

1 stop5h 27m

Des Moines

Wed 5/6

2:58 pm-10:59 pm

1 stop8h 01m

$314

MilwaukeeDes Moines

MKE - DSM

MKEDSM

Milwaukee-Mitchell

Wed 3/18

5:09 am-8:49 am

1 stop3h 40m

Des Moines

Sun 3/22

5:00 am-7:49 am

1 stop26h 49m

$330

MilwaukeeDes Moines

MKE - DSM

MKEDSM

Milwaukee-Mitchell

Tue 7/7

6:00 am-11:30 am

1 stop5h 30m

Des Moines

Thu 7/9

5:10 am-6:05 pm

2 stops12h 55m

$333
Cheapest one-way

MilwaukeeDes Moines

MKE - DSM

MKEDSM

Milwaukee-Mitchell

Tue 4/28

8:00 am-10:10 pm

2 stops14h 10m

$137
Quickest one-way

MilwaukeeDes Moines

MKE - DSM

MKEDSM

Milwaukee-Mitchell

Fri 4/3

12:16 pm-3:42 pm

1 stop3h 26m

$139

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/2

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Compare providers for flights from Milwaukee to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Milwaukee to Des Moines in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Milwaukee-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Milwaukee-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Milwaukee-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Milwaukee-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Milwaukee-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Milwaukee to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Milwaukee with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Milwaukee to Des Moines

What is the cheapest month to book a flight from Milwaukee to Des Moines?

Currently, April is the cheapest month in which you can book a flight from Milwaukee to Des Moines (average of $129). Flying from Milwaukee to Des Moines in December is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated March 5, 2026.
See what other customers who have flown with American Airlines from Milwaukee to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,381 reviews

Food

6.4

Crew

8.0

Overall

7.2

Entertainment

6.9

Boarding

7.5

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,381 reviews
American Airlines
7.2
Good
11,381 reviews

Food

6.4

Crew

8.0

Overall

7.2

Entertainment

6.9

Boarding

7.5

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Milwaukee to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Milwaukee to Des Moines?

    Airlines like Frontier, United Airlines, and Southwest fly from Milwaukee to Des Moines in about 4h 11m. The time it takes to get you to your destination can typically vary by up to 9h 14m. There are 310 mi between Milwaukee and Des Moines. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Milwaukee to Des Moines round-trip?

    American Airlines, at $174, was found to be the cheapest airline from Milwaukee to Des Moines..

  • Can I find deals for flights from Milwaukee to Des Moines that include hotel bookings?

    Yes. In addition to deals on Milwaukee to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Milwaukee to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Milwaukee to Des Moines.

  • Can I find deals for business class flights from Milwaukee to Des Moines?

    Yes. Cheapflights offers flight deals from Milwaukee to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Milwaukee to Des Moines?

    Currently, April is the cheapest month in which you can book a flight from Milwaukee to Des Moines (average of $129). Flying from Milwaukee to Des Moines in December is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ankeny
Ames
Boone
Clive
West Des Moines

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Milwaukee to Des Moines

Discover the top airline that operate flights from Milwaukee to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$174Average$261FlexibilityNo cancel feeOn-time71%

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