$87+ Cheap flights from Mesa, AZ to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/27. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Sep 3 — Sep 101
Round-trip
1 adult, Economy
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Find cheap flights from Mesa to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in November or October, booked 65 days in advance, depart on a Wednesday or Monday and return on a Wednesday
Cheap flight deals from Mesa to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mesa to Des MoinesExplore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2026.
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:24 pm -
1 stop23h 17m
Mon 9/219:31 pm -
1 stop23h 32m
Deal found 7/31![Multiple Airlines logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:09 pm -
1 stop20h 51m
Mon 8/318:54 pm -
1 stop18h 05m
Deal found 8/1![Multiple Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:30 pm -
1 stop18h 18m
Mon 8/318:54 pm -
1 stop18h 05m
Deal found 8/1![Multiple Airlines logo]()
$183
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:24 pm -
1 stop23h 17m
Mon 9/149:31 pm -
1 stop16h 28m
Deal found 8/1![Multiple Airlines logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/511:40 pm -
1 stop20h 55m
Mon 11/98:04 pm -
1 stop16h 45m
Deal found 8/2![Multiple Airlines logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:30 pm -
1 stop18h 18m
Sun 8/309:50 pm -
1 stop16h 58m
Deal found 8/4![Multiple Airlines logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/289:03 am -
1 stop7h 45m
Mon 8/318:54 pm -
1 stop28h 30m
Deal found 8/4![Multiple Airlines logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/279:03 am -
1 stop9h 57m
Fri 8/287:38 pm -
1 stop19h 10m
Deal found 8/1![Multiple Airlines logo]()
$202
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:30 am -
1 stop10h 12m
Sun 10/1110:09 pm -
1 stop14h 04m
Deal found 8/1![Multiple Airlines logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:25 am -
1 stop11h 08m
Mon 9/149:31 pm -
1 stop16h 28m
Deal found 8/3![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:24 pm -
1 stop23h 17m
Sun 9/1311:29 am -
1 stop14h 14m
Deal found 8/3![Multiple Airlines logo]()
$207
Best flights from Mesa to Des MoinesDiscover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 4, 2026.
Discover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 4, 2026.
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/11:50 pm -
Nonstop2h 40m
Mon 10/52:00 pm -
Nonstop3h 05m
Deal found 8/4![Southwest logo]()
$377
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:00 am -
1 stop9h 11m
Fri 8/286:55 am -
1 stop7h 42m
Deal found 8/2![Delta logo]()
$410
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1110:00 am -
2 stops9h 20m
Mon 9/142:25 pm -
2 stops8h 10m
Deal found 7/30![Southwest logo]()
$383
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/51:50 pm -
Nonstop2h 40m
Wed 10/75:35 am -
1 stop7h 15m
Deal found 7/31![Southwest logo]()
$387
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/81:50 pm -
Nonstop2h 40m
Sun 10/115:30 am -
1 stop7h 20m
Deal found 7/31![Southwest logo]()
$389
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:25 am -
2 stops7h 55m
Mon 9/213:50 pm -
2 stops8h 10m
Deal found 8/2![Southwest logo]()
$407
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/211:00 am -
2 stops8h 00m
Wed 9/97:15 am -
2 stops7h 05m
Deal found 8/3![Southwest logo]()
$407
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:25 am -
2 stops7h 55m
Sun 9/135:40 am -
2 stops9h 00m
Deal found 8/2![Southwest logo]()
$409
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1812:50 pm -
2 stops8h 00m
Sat 10/247:00 am -
2 stops8h 15m
Deal found 8/2![Southwest logo]()
$433
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:25 am -
2 stops7h 55m
Sun 9/67:05 am -
2 stops8h 00m
Deal found 8/2![Southwest logo]()
$446
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:45 pm -
1 stop6h 30m
Mon 9/75:40 am -
2 stops8h 10m
Deal found 8/2![Southwest logo]()
$454
Last-minute flights from Mesa to Des MoinesDiscover last-minute flight deals from Mesa to Des Moines. Data last updated August 4, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to Des Moines. Data last updated August 4, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:09 pm -
1 stop20h 51m
Mon 8/318:54 pm -
1 stop18h 05m
Deal found 8/1![Multiple Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:30 pm -
1 stop18h 18m
Mon 8/318:54 pm -
1 stop18h 05m
Deal found 8/1![Multiple Airlines logo]()
$183
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:30 pm -
1 stop18h 18m
Sun 8/309:50 pm -
1 stop16h 58m
Deal found 8/4![Multiple Airlines logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/279:03 am -
1 stop9h 57m
Fri 8/287:38 pm -
1 stop19h 10m
Deal found 8/1![Multiple Airlines logo]()
$202
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/289:03 am -
1 stop7h 45m
Mon 8/318:54 pm -
1 stop28h 30m
Deal found 8/4![Multiple Airlines logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:24 pm -
1 stop23h 17m
Mon 9/219:31 pm -
1 stop23h 32m
Deal found 7/31![Multiple Airlines logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:24 pm -
1 stop23h 17m
Mon 9/149:31 pm -
1 stop16h 28m
Deal found 8/1![Multiple Airlines logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:24 pm -
1 stop23h 17m
Sun 9/1311:29 am -
1 stop14h 14m
Deal found 8/3![Multiple Airlines logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:25 am -
1 stop11h 08m
Mon 9/149:31 pm -
1 stop16h 28m
Deal found 8/3![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:29 am -
1 stop6h 04m
Sun 9/1311:29 am -
1 stop14h 14m
Deal found 8/2![Frontier logo]()
$220
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/168:39 pm -
1 stop22h 27m
Sun 9/209:56 pm -
1 stop26h 51m
Deal found 8/2![Multiple Airlines logo]()
$204
One-way flights from Mesa to Des MoinesSearch for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated August 4, 2026.
Search for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated August 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:05 am -
1 stop28h 47m
Deal found 7/31![Multiple Airlines logo]()
$87
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:30 pm -
1 stop18h 18m
Deal found 7/30![Multiple Airlines logo]()
$88
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:09 pm -
1 stop20h 51m
Deal found 8/1![Multiple Airlines logo]()
$92
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:00 am -
1 stop24h 57m
Deal found 8/4![Multiple Airlines logo]()
$96
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:39 pm -
1 stop15h 13m
Deal found 8/1![Multiple Airlines logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/68:39 pm -
1 stop15h 13m
Deal found 8/3![Multiple Airlines logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:30 pm -
1 stop10h 40m
Deal found 7/31![Multiple Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/289:03 am -
1 stop7h 45m
Deal found 8/4![Multiple Airlines logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2912:09 pm -
1 stop7h 52m
Deal found 7/31![Multiple Airlines logo]()
$112
Find flight deals from Mesa to Des Moines
Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated August 4, 2026.
Round-trip from | $181 (Kiwi.com) |
|---|---|
One-way from | $87 (Kiwi.com) |
Popular in | July |
Cheapest in | November |
Average price | $388 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 10/1
1:50 pm-6:30 pm
Nonstop2h 40m
Des Moines
Mon 10/5
2:00 pm-3:05 pm
Nonstop3h 05m
$377
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Fri 9/11
10:00 am-9:20 pm
2 stops9h 20m
Des Moines
Mon 9/14
2:25 pm-8:35 pm
2 stops8h 10m
$383
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Mon 10/5
1:50 pm-6:30 pm
Nonstop2h 40m
Des Moines
Wed 10/7
5:35 am-10:50 am
1 stop7h 15m
$387
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 10/8
1:50 pm-6:30 pm
Nonstop2h 40m
Des Moines
Sun 10/11
5:30 am-10:50 am
1 stop7h 20m
$389
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 9/10
11:25 am-9:20 pm
2 stops7h 55m
Des Moines
Mon 9/21
3:50 pm-10:00 pm
2 stops8h 10m
$407
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Wed 9/2
11:00 am-9:00 pm
2 stops8h 00m
Des Moines
Wed 9/9
7:15 am-12:20 pm
2 stops7h 05m
$407
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Fri 9/11
11:25 am-9:20 pm
2 stops7h 55m
Des Moines
Sun 9/13
5:40 am-12:40 pm
2 stops9h 00m
$409
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 8/25
6:00 am-5:11 pm
1 stop9h 11m
Des Moines
Fri 8/28
6:55 am-12:37 pm
1 stop7h 42m
$410
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sun 10/18
12:50 pm-10:50 pm
2 stops8h 00m
Des Moines
Sat 10/24
7:00 am-1:15 pm
2 stops8h 15m
$433
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 9/3
11:25 am-9:20 pm
2 stops7h 55m
Des Moines
Sun 9/6
7:05 am-1:05 pm
2 stops8h 00m
$446
Showing 1-10 of 20 resultsSorted by cheapest first
Best time to book a flight from Mesa to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
PHX-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Des Moines
MS9-DSM
PHX-DSM
What is the cheapest time of day to fly from MS9 to DSM?
Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 4, 2026.
It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 30% on the flight price compared to flying in the afternoon, which is usually more expensive.
How much does it cost to fly round-trip from Mesa to Des Moines?
Airfare is below average for this route at the moment.
Mesa to Des Moines flights typically cost between $349 and $468 in September.The cheapest round-trip price found within the last 5 days was $181 on Multiple Airlines (Sep 10-Sep 21).
What is the cheapest day to fly from Mesa to Des Moines?
Use this chart to determine the cheapest time to fly round-trip from Mesa to Des Moines. Price data was last updated on August 1, 2026.
Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Saturday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated August 4, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAmerican Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Ames
Clive
Johnston
Boone
Norwalk
West Des Moines
Ankeny
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Top 5 airlines flying from Mesa to Des Moines
Discover the top 5 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$118 | Average$213 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$140 | Average$240 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$232 | Average$419 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$255 | Average$408 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$318 | Average$383 | FlexibilityNo cancel fee | On-time69% |