$101+ Cheap flights from Mesa, AZ to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/26. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Jun 4 — Jun 111
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Mesa to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in November or May, booked 65 days in advance, depart on a Tuesday or Saturday and return on a Wednesday
Cheap flight deals from Mesa to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mesa to Des MoinesExplore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
This Expedia deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2811:19 am
PHX
- DSM
1 stop24h 15m
Frontier
Wed 8/52:19 pm
DSM
- PHX
1 stop21h 52m
Frontier
Deal found 5/1![Frontier logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/310:27 pm
PHX
- DSM
1 stop19h 44m
Multiple Airlines
Wed 6/242:16 pm
DSM
- PHX
1 stop19h 29m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:03 pm
PHX
- DSM
1 stop27h 43m
Multiple Airlines
Mon 6/159:56 pm
DSM
- PHX
1 stop16h 59m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$214
This Expedia deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:53 pm
PHX
- DSM
1 stop16h 41m
Frontier
Mon 8/172:19 pm
DSM
- PHX
1 stop11h 13m
Frontier
Deal found 5/4![Frontier logo]()
$218
This Expedia deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:15 am
PHX
- DSM
1 stop6h 16m
Frontier
Mon 6/82:16 pm
DSM
- PHX
1 stop27h 32m
Frontier
Deal found 5/4![Frontier logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:53 pm
PHX
- DSM
1 stop16h 38m
Frontier
Fri 6/192:16 pm
DSM
- PHX
1 stop22h 05m
Frontier
Deal found 5/4![Frontier logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/114:43 pm
PHX
- DSM
1 stop18h 48m
Multiple Airlines
Mon 6/159:56 pm
DSM
- PHX
1 stop16h 59m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$227
This Frontier deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:40 am
PHX
- DSM
1 stop4h 54m
Frontier
Mon 8/102:19 pm
DSM
- PHX
1 stop11h 13m
Frontier
Deal found 5/1![Frontier logo]()
$234
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/111:26 am
PHX
- DSM
2 stops48h 05m
Multiple Airlines
Mon 6/89:56 pm
DSM
- PHX
1 stop14h 57m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/254:43 pm
PHX
- DSM
1 stop18h 48m
Multiple Airlines
Mon 6/299:56 pm
DSM
- PHX
1 stop16h 59m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:00 pm
PHX
- DSM
1 stop28h 54m
Multiple Airlines
Mon 8/1010:06 pm
DSM
- PHX
1 stop16h 49m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$238
Best flights from Mesa to Des MoinesDiscover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
Discover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:40 am
PHX
- DSM
2 stops7h 20m
Southwest
Tue 9/86:10 am
DSM
- PHX
2 stops8h 20m
Southwest
Deal found 5/3![Southwest logo]()
$371
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2912:59 am
PHX
- DSM
1 stop7h 17m
Delta
Tue 6/27:01 am
DSM
- PHX
1 stop5h 48m
Delta
Deal found 5/2![Delta logo]()
$371
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1710:25 am
PHX
- DSM
2 stops9h 15m
Southwest
Wed 6/243:45 pm
DSM
- PHX
2 stops8h 10m
Southwest
Deal found 5/3![Southwest logo]()
$371
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1211:59 pm
PHX
- DSM
1 stop8h 50m
Delta
Tue 6/166:50 am
DSM
- PHX
1 stop5h 56m
Delta
Deal found 5/4![Delta logo]()
$400
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:30 am
PHX
- DSM
1 stop5h 00m
Southwest
Sun 7/56:10 am
DSM
- PHX
2 stops8h 05m
Southwest
Deal found 5/1![Southwest logo]()
$399
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:05 am
PHX
- DSM
2 stops8h 00m
Southwest
Wed 8/57:15 am
DSM
- PHX
2 stops7h 25m
Southwest
Deal found 5/1![Southwest logo]()
$407
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/211:55 pm
PHX
- DSM
Nonstop2h 40m
Southwest
Mon 5/251:45 pm
DSM
- PHX
Nonstop2h 55m
Southwest
Deal found 4/30![Southwest logo]()
$413
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/309:05 am
PHX
- DSM
2 stops9h 50m
Southwest
Mon 6/14:20 pm
DSM
- PHX
2 stops8h 50m
Southwest
Deal found 4/30![Southwest logo]()
$421
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/110:40 am
PHX
- DSM
2 stops10h 10m
Southwest
Mon 8/31:30 pm
DSM
- PHX
2 stops8h 20m
Southwest
Deal found 5/2![Southwest logo]()
$429
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1111:20 am
PHX
- DSM
2 stops9h 00m
Southwest
Mon 6/151:30 pm
DSM
- PHX
2 stops8h 45m
Southwest
Deal found 5/2![Southwest logo]()
$450
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1311:05 am
PHX
- DSM
2 stops9h 15m
Southwest
Fri 7/176:10 am
DSM
- PHX
2 stops8h 05m
Southwest
Deal found 5/1![Southwest logo]()
$450
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1311:25 am
PHX
- DSM
2 stops7h 50m
Southwest
Mon 8/173:50 pm
DSM
- PHX
2 stops8h 05m
Southwest
Deal found 5/4![Southwest logo]()
$450
Last-minute flights from Mesa to Des MoinesDiscover last-minute flight deals from Mesa to Des Moines. Data last updated May 5, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to Des Moines. Data last updated May 5, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:27 pm
PHX
- DSM
1 stop20h 17m
Multiple Airlines
Mon 6/19:17 pm
DSM
- PHX
1 stop16h 06m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$245
This Expedia deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:15 am
PHX
- DSM
1 stop6h 16m
Frontier
Mon 6/82:16 pm
DSM
- PHX
1 stop27h 32m
Frontier
Deal found 5/4![Frontier logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/111:26 am
PHX
- DSM
2 stops48h 05m
Multiple Airlines
Mon 6/89:56 pm
DSM
- PHX
1 stop14h 57m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/310:27 pm
PHX
- DSM
1 stop19h 44m
Multiple Airlines
Wed 6/242:16 pm
DSM
- PHX
1 stop19h 29m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:03 pm
PHX
- DSM
1 stop27h 43m
Multiple Airlines
Mon 6/159:56 pm
DSM
- PHX
1 stop16h 59m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/114:43 pm
PHX
- DSM
1 stop18h 48m
Multiple Airlines
Mon 6/159:56 pm
DSM
- PHX
1 stop16h 59m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$227
This CheapOair deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:53 pm
PHX
- DSM
1 stop16h 38m
Frontier
Mon 6/152:26 pm
DSM
- PHX
1 stop24h 54m
Frontier
Deal found 5/5![Frontier logo]()
$260
This Frontier deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/126:40 am
PHX
- DSM
1 stop4h 51m
Frontier
Fri 6/192:16 pm
DSM
- PHX
1 stop9h 05m
Frontier
Deal found 5/4![Frontier logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:53 pm
PHX
- DSM
1 stop16h 38m
Frontier
Fri 6/192:16 pm
DSM
- PHX
1 stop22h 05m
Frontier
Deal found 5/4![Frontier logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/254:43 pm
PHX
- DSM
1 stop18h 48m
Multiple Airlines
Mon 6/299:56 pm
DSM
- PHX
1 stop16h 59m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$237
One-way flights from Mesa to Des MoinesSearch for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
Search for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2610:27 pm
PHX
- DSM
1 stop12h 32m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3011:21 am
PHX
- DSM
1 stop24h 10m
Frontier
Deal found 4/30![Frontier logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/310:27 pm
PHX
- DSM
1 stop19h 44m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/2511:26 am
PHX
- DSM
2 stops48h 05m
Frontier
Deal found 5/3![Frontier logo]()
$107
This Expedia deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2811:19 am
PHX
- DSM
1 stop24h 15m
Frontier
Deal found 5/2![Frontier logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:40 am
PHX
- DSM
1 stop10h 31m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:40 am
PHX
- DSM
2 stops27h 51m
Frontier
Deal found 5/1![Frontier logo]()
$118
This Super.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:15 am
PHX
- DSM
1 stop6h 16m
Frontier
Deal found 4/30![Frontier logo]()
$120
This Super.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:15 am
PHX
- DSM
1 stop6h 16m
Frontier
Deal found 5/4![Frontier logo]()
$124
This Frontier deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:40 am
PHX
- DSM
1 stop4h 54m
Frontier
Deal found 5/4![Frontier logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:40 am
PHX
- DSM
2 stops37h 08m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$126
Find flight deals from Mesa to Des Moines
Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated May 5, 2026.
Round-trip from | $210 (Expedia) |
|---|---|
One-way from | $101 (Kiwi.com) |
Popular in | April |
Cheapest in | November |
Average price | $339 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 9/1
11:40 am-9:00 pm
2 stops7h 20m
Des Moines
Tue 9/8
6:10 am-12:30 pm
2 stops8h 20m
$371
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Fri 5/29
12:59 am-10:16 am
1 stop7h 17m
Des Moines
Tue 6/2
7:01 am-10:49 am
1 stop5h 48m
$371
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Wed 6/17
10:25 am-9:40 pm
2 stops9h 15m
Des Moines
Wed 6/24
3:45 pm-9:55 pm
2 stops8h 10m
$371
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 7/4
7:30 am-2:30 pm
1 stop5h 00m
Des Moines
Sun 7/5
6:10 am-12:15 pm
2 stops8h 05m
$399
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Fri 6/12
11:59 pm-10:49 am
1 stop8h 50m
Des Moines
Tue 6/16
6:50 am-10:46 am
1 stop5h 56m
$400
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 7/28
5:05 am-3:05 pm
2 stops8h 00m
Des Moines
Wed 8/5
7:15 am-12:40 pm
2 stops7h 25m
$407
Quickest round-trip
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 5/21
1:55 pm-6:35 pm
Nonstop2h 40m
Des Moines
Mon 5/25
1:45 pm-2:40 pm
Nonstop2h 55m
$413
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 5/30
9:05 am-8:55 pm
2 stops9h 50m
Des Moines
Mon 6/1
4:20 pm-11:10 pm
2 stops8h 50m
$421
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 8/1
10:40 am-10:50 pm
2 stops10h 10m
Des Moines
Mon 8/3
1:30 pm-7:50 pm
2 stops8h 20m
$429
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 6/11
11:20 am-10:20 pm
2 stops9h 00m
Des Moines
Mon 6/15
1:30 pm-8:15 pm
2 stops8h 45m
$450
Showing 1-10 of 23 resultsSorted by cheapest first
Best time to book a flight from Mesa to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
PHX-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Des Moines
MS9-DSM
PHX-DSM
What is the cheapest time of day to fly from MS9 to DSM?
Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 5, 2026.
It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 25% on the flight price compared to flying at noon, which is usually more expensive.
What is the cheapest day to fly from Mesa to Des Moines?
Use this chart to determine the cheapest time to fly round-trip from Mesa to Des Moines. Price data was last updated on May 2, 2026.
Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Saturday evenings when fares are most often at their lowest. Tuesday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
How much does it cost to fly round-trip from Mesa to Des Moines?
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated May 5, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAllegiant Air from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Des Moines flight routes
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Mesa to Des Moines
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 5, 2026.
Search flights from Mesa to Des Moines by cabin class
Find flights from Mesa to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mesa and Des Moines flights
Browse other Mesa and Des Moines flight options. Last updated on May 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Mesa to Des Moines flights
Consider these flights traveling from Mesa to Des Moines.
Top 6 airlines flying from Mesa to Des Moines
Discover the top 6 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$67 | Average$176 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$118 | Average$213 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$164 | Average$278 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$222 | Average$377 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$227 | Average$391 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$275 | Average$376 | FlexibilityNo cancel fee | On-time69% |