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Des Moines

$95+ Cheap flights from Mesa, AZ to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
May 5 — May 121
Mon 5/5
Mon 5/12
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in October or February, booked 85 days in advance, depart on a Tuesday or Saturday and return on a Tuesday

Cheap flight deals from Mesa to Des Moines

Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated April 30, 2025.

Round-trip from

$197
(American Airlines)

One-way from

$95
(Frontier)

Popular in

January

Cheapest in

October

Average price

$333
From Mesa to Des Moines
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One-way flight from Mesa to Des Moines
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Highest demand for flights based on searches. 6% potential increase in price ($26 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Mesa to Des Moines

Cheapest flights from Mesa to Des Moines
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2025.

This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/216:55 pmPHX - DSM
Nonstop2h 45mAmerican Airlines
Wed 5/282:44 pmDSM - PHX
Nonstop3h 08mAmerican Airlines
Deal found 4/28$228
This CheapOair deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/201:17 pmPHX - DSM
1 stop27h 13mFrontier
Mon 5/268:20 pmDSM - PHX
1 stop23h 02mFrontier
Deal found 4/28$231
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2112:45 amPHX - DSM
1 stop7h 31mDelta
Tue 7/292:29 pmDSM - PHX
1 stop9h 13mDelta
Deal found 4/28$237
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/217:30 amPHX - DSM
1 stop5h 25mSouthwest
Wed 5/283:40 pmDSM - PHX
Nonstop3h 05mSouthwest
Deal found 4/28$248
This Mytrip deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1510:45 amPHX - DSM
2 stops32h 42mMultiple Airlines
Sun 5/1812:32 pmDSM - PHX
2 stops21h 41mMultiple Airlines
Deal found 4/28$346
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/76:00 amPHX - DSM
2 stops8h 18mUnited Airlines
Fri 6/276:00 amDSM - PHX
1 stop4h 49mUnited Airlines
Deal found 4/28$360

Cheapflights Fare Finder

Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.

Fly from

Mesa

Fly to

Des Moines

Route

Depart

Return

Price

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 5/21

6:55 pm-11:40 pm

Nonstop2h 45m

Des Moines

Wed 5/28

2:44 pm-3:52 pm

Nonstop3h 08m

$228

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Tue 5/20

1:17 pm-6:30 pm

1 stop27h 13m

Des Moines

Mon 5/26

8:20 pm-5:22 pm

1 stop23h 02m

$231

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Mon 7/21

12:45 am-10:16 am

1 stop7h 31m

Des Moines

Tue 7/29

2:39 pm-8:03 pm

1 stop7h 24m

$237

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 5/21

7:30 am-2:55 pm

1 stop5h 25m

Des Moines

Wed 5/28

3:40 pm-4:45 pm

Nonstop3h 05m

$248

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 5/15

10:45 am-9:27 pm

2 stops32h 42m

Des Moines

Sun 5/18

12:32 pm-8:13 am

2 stops21h 41m

$346

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Sat 6/7

6:00 am-4:18 pm

2 stops8h 18m

Des Moines

Fri 6/27

6:00 am-8:49 am

1 stop4h 49m

$360

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Mon 5/5

5:50 am-6:30 pm

1 stop10h 40m

$95

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 5/28

8:35 am-1:20 pm

Nonstop2h 45m

$100

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 5/29

9:19 am-9:31 pm

1 stop10h 12m

$106

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Tue 5/27

12:45 am-10:19 am

1 stop7h 34m

$119

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Showing 1-10 of 13 results
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Best time to book a flight from Mesa to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Des Moines

How far ahead should I book a flight from Mesa to Des Moines?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Des Moines. Price data was last updated on April 25, 2025.

The price you pay for your flight from Mesa to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 85 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $336). Flying from Mesa to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to DSM?

Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 30, 2025.

When flying from Mesa to Des Moines, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Mesa to Des Moines?

Use this chart to determine the cheapest time to fly round-trip from Mesa to Des Moines. Price data was last updated on March 30, 2025.

Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Wednesday evenings when fares are most often at their lowest. Saturday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 30, 2025.
Read through reviews of airlines operating flights from Mesa to Des Moines, such as Southwest, Delta and United Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,295 reviews

Crew

8.6

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,295 reviews
Southwest
8.0
Very good
4,295 reviews

Crew

8.6

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,929 reviews
Southwest
8.0
Very good
4,295 reviews

Crew

8.6

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,696 reviews
Southwest
8.0
Very good
4,295 reviews

Crew

8.6

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Allegiant Air
7.3
Good
734 reviews
Southwest
8.0
Very good
4,295 reviews

Crew

8.6

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,295 reviews

Crew

8.6

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mesa?

    For a flight from Mesa to Des Moines, you will be flying into Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 3 inbound flights from Mesa per day. 6 airlines have flights to Des Moines from Mesa on a regular basis.

  • What are the cheapest airlines to fly from Mesa to Des Moines one-way?

    One-way options have recently been found by users for as low as $95 on Frontier. Other airlines that offer cheap prices include American Airlines from $100 and Delta from $119 one-way.

  • What are the most reliable airlines from Mesa to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mesa to Des Moines on time: Southwest (87%), Envoy Air (85%), American Airlines (85%).

  • What are the cheapest flights from Mesa to Des Moines?

    While on average a flight from Mesa to Des Moines is generally $309, our data shows the cheapest flight currently is $89. When looking at the most popular route, (Phoenix Sky Harbor Intl - Des Moines), you can expect to pay $236 for that flight.

  • Can I find deals for flights from Mesa to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mesa to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Des Moines.

  • Can I find deals for business class flights from Mesa to Des Moines?

    Yes. Cheapflights offers flight deals from Mesa to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $336). Flying from Mesa to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Mesa?

Book flights to Mesa if you plan to visit one of these locations
Ames
Altoona
Johnston
Boone
West Des Moines
Ankeny

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Top 6 airlines flying from Mesa to Des Moines

Discover the top 6 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$100Average$201FlexibilityNo cancel feeOn-time88%
FrontierCheapest$104Average$191FlexibilityNo cancel feeOn-time62%
DeltaCheapest$216Average$307FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$216Average$577FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$217Average$371FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$237Average$375FlexibilityNo cancel feeOn-time63%

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