$49+ Cheap flights from Mesa, AZ to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/14. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Mar 15 — Mar 221
1 adult, Economy
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Find cheap flights from Mesa to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in April or November, booked 79 days in advance, depart on a Tuesday or Wednesday and return on a Wednesday
Cheap flight deals from Mesa to Des Moines
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Best
Last-minute
One-way
Cheapest flights from Mesa to Des MoinesExplore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.
This Super.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:30 am
PHX
- DSM
Nonstop2h 41m
Frontier
Sat 3/212:56 pm
DSM
- PHX
Nonstop3h 20m
Frontier
Deal found 2/13![Frontier logo]()
$109
This Frontier deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/1611:17 am
PHX
- DSM
Nonstop2h 41m
Frontier
Sat 3/212:56 pm
DSM
- PHX
Nonstop3h 20m
Frontier
Deal found 2/13![Frontier logo]()
$150
This Super.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1311:17 am
PHX
- DSM
Nonstop2h 41m
Frontier
Fri 3/204:43 pm
DSM
- PHX
Nonstop3h 20m
Frontier
Deal found 2/13![Frontier logo]()
$159
This Frontier deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/269:17 am
PHX
- DSM
1 stop8h 25m
Frontier
Mon 3/27:17 pm
DSM
- PHX
1 stop6h 24m
Frontier
Deal found 2/9![Frontier logo]()
$164
This Trip.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:52 am
PHX
- DSM
1 stop9h 12m
Frontier
Mon 3/27:17 pm
DSM
- PHX
1 stop6h 24m
Frontier
Deal found 2/10![Frontier logo]()
$173
This Frontier deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/59:17 am
PHX
- DSM
1 stop8h 25m
Frontier
Tue 3/1710:40 am
DSM
- PHX
1 stop15h 04m
Frontier
Deal found 2/11![Frontier logo]()
$189
This Super.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:00 am
PHX
- DSM
1 stop11h 42m
Frontier
Sun 3/17:27 pm
DSM
- PHX
1 stop13h 45m
Frontier
Deal found 2/11![Frontier logo]()
$191
Best flights from Mesa to Des MoinesDiscover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 13, 2026.
Discover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 13, 2026.
This Frontier deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/1611:17 am
PHX
- DSM
Nonstop2h 41m
Frontier
Sat 3/212:56 pm
DSM
- PHX
Nonstop3h 20m
Frontier
Deal found 2/13![Frontier logo]()
$150
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:46 pm
PHX
- DSM
1 stop9h 17m
Delta
Wed 5/205:28 pm
DSM
- PHX
1 stop8h 04m
Delta
Deal found 2/12![Delta logo]()
$239
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1010:10 am
PHX
- DSM
Nonstop2h 45m
Southwest
Tue 3/173:40 pm
DSM
- PHX
1 stop6h 50m
Southwest
Deal found 2/10![Southwest logo]()
$239
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/121:50 pm
PHX
- DSM
2 stops7h 54m
United Airlines
Wed 5/205:17 pm
DSM
- PHX
1 stop5h 02m
United Airlines
Deal found 2/11![United Airlines logo]()
$302
This American Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:52 am
PHX
- DSM
Nonstop2h 53m
American Airlines
Tue 11/106:20 pm
DSM
- PHX
Nonstop3h 14m
American Airlines
Deal found 2/13![American Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/256:51 pm
PHX
- DSM
1 stop22h 51m
Frontier
Mon 3/27:17 pm
DSM
- PHX
1 stop14h 25m
Frontier
Deal found 2/13![Frontier logo]()
$209
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/111:25 pm
PHX
- DSM
2 stops5h 25m
Southwest
Tue 3/171:55 pm
DSM
- PHX
Nonstop3h 05m
Southwest
Deal found 2/10![Southwest logo]()
$244
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:25 am
PHX
- DSM
1 stop5h 50m
Southwest
Mon 4/62:15 pm
DSM
- PHX
Nonstop3h 05m
Southwest
Deal found 2/11![Southwest logo]()
$289
Last-minute flights from Mesa to Des MoinesDiscover last-minute flight deals from Mesa to Des Moines. Data last updated February 13, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to Des Moines. Data last updated February 13, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/269:17 am
PHX
- DSM
1 stop8h 25m
Frontier
Mon 3/27:17 pm
DSM
- PHX
1 stop6h 24m
Frontier
Deal found 2/9![Frontier logo]()
$164
This Super.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:00 am
PHX
- DSM
1 stop11h 42m
Frontier
Sun 3/17:27 pm
DSM
- PHX
1 stop13h 45m
Frontier
Deal found 2/11![Frontier logo]()
$191
This Trip.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:52 am
PHX
- DSM
1 stop9h 12m
Frontier
Mon 3/27:17 pm
DSM
- PHX
1 stop6h 24m
Frontier
Deal found 2/10![Frontier logo]()
$173
This Frontier deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/59:17 am
PHX
- DSM
1 stop8h 25m
Frontier
Tue 3/1710:40 am
DSM
- PHX
1 stop15h 04m
Frontier
Deal found 2/11![Frontier logo]()
$189
This Super.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1311:17 am
PHX
- DSM
Nonstop2h 41m
Frontier
Fri 3/204:43 pm
DSM
- PHX
Nonstop3h 20m
Frontier
Deal found 2/13![Frontier logo]()
$159
This Super.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:30 am
PHX
- DSM
Nonstop2h 41m
Frontier
Sat 3/212:56 pm
DSM
- PHX
Nonstop3h 20m
Frontier
Deal found 2/13![Frontier logo]()
$109
This Frontier deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/1611:17 am
PHX
- DSM
Nonstop2h 41m
Frontier
Sat 3/212:56 pm
DSM
- PHX
Nonstop3h 20m
Frontier
Deal found 2/13![Frontier logo]()
$150
One-way flights from Mesa to Des MoinesSearch for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated February 13, 2026.
Search for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated February 13, 2026.
This Frontier deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:30 am
PHX
- DSM
Nonstop2h 41m
Frontier
Deal found 2/11![Frontier logo]()
$49
This Trip.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/59:17 am
PHX
- DSM
1 stop8h 25m
Frontier
Deal found 2/13![Frontier logo]()
$78
This Frontier deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1311:17 am
PHX
- DSM
Nonstop2h 41m
Frontier
Deal found 2/12![Frontier logo]()
$84
This Super.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/1611:17 am
PHX
- DSM
Nonstop2h 41m
Frontier
Deal found 2/12![Frontier logo]()
$88
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/103:11 pm
PHX
- DSM
1 stop26h 05m
Frontier
Deal found 2/12![Frontier logo]()
$89
This Frontier deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:50 am
PHX
- DSM
1 stop4h 39m
Frontier
Deal found 2/11![Frontier logo]()
$90
This Super.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/129:24 pm
PHX
- DSM
1 stop19h 50m
Frontier
Deal found 2/13![Frontier logo]()
$95
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:50 am
PHX
- DSM
1 stop10h 24m
Frontier
Deal found 2/10![Frontier logo]()
$96
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/71:52 pm
PHX
- DSM
1 stop4h 24m
Frontier
Deal found 2/10![Frontier logo]()
$99
This Super.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/812:59 am
PHX
- DSM
1 stop31h 06m
Frontier
Deal found 2/10![Frontier logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:02 pm
PHX
- DSM
1 stop23h 09m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$105
Find flight deals from Mesa to Des Moines
Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated February 13, 2026.
Round-trip from | $109 (Super.com) |
|---|---|
One-way from | $49 (Frontier) |
Popular in | March |
Cheapest in | April |
Average price | $377 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.
Fly from
Mesa
Fly to
Des Moines
Route
Depart
Return
Price
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Mon 3/16
11:17 am-3:58 pm
Nonstop2h 41m
Des Moines
Sat 3/21
2:56 pm-4:16 pm
Nonstop3h 20m
$150
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Wed 2/25
6:51 pm-6:42 pm
1 stop22h 51m
Des Moines
Mon 3/2
7:17 pm-8:42 am
1 stop14h 25m
$209
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 5/12
11:46 pm-11:03 am
1 stop9h 17m
Des Moines
Wed 5/20
5:28 pm-11:32 pm
1 stop8h 04m
$239
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 3/10
10:10 am-2:55 pm
Nonstop2h 45m
Des Moines
Tue 3/17
3:40 pm-8:30 pm
1 stop6h 50m
$239
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Wed 3/11
1:25 pm-8:50 pm
2 stops5h 25m
Des Moines
Tue 3/17
1:55 pm-3:00 pm
Nonstop3h 05m
$244
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Wed 4/1
5:25 am-1:15 pm
1 stop5h 50m
Des Moines
Mon 4/6
2:15 pm-3:20 pm
Nonstop3h 05m
$289
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 5/12
1:50 pm-11:44 pm
2 stops7h 54m
Des Moines
Wed 5/20
5:17 pm-8:19 pm
1 stop5h 02m
$302
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 4/16
8:52 am-1:45 pm
Nonstop2h 53m
Des Moines
Tue 11/10
6:20 pm-8:34 pm
Nonstop3h 14m
$304
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 3/14
9:30 am-2:11 pm
Nonstop2h 41m
$49
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Mon 5/11
6:50 am-1:29 pm
1 stop4h 39m
$90
Showing 1-10 of 19 results
Best time to book a flight from Mesa to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
PHX-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Des Moines
MS9-DSM
PHX-DSM
How far ahead should I book a flight from Mesa to Des Moines?
Use this chart to determine the optimal time to book a round-trip flight from Mesa to Des Moines. Price data was last updated on February 6, 2026.
The price you pay for your flight from Mesa to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 78 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Mesa to Des Moines?
Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in March is currently the most expensive (average of $204). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MS9 to DSM?
Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 13, 2026.
It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 27% on the flight price compared to flying in the morning, which is usually more expensive.
Weekly flight availability from Mesa to Des Moines
Explore weekly flight availability from Mesa to Des Moines. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated February 13, 2026.
The most flights from MS9 to DSM are scheduled on a Thursday (7 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (2 on average).
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated February 13, 2026.
Read reviews from past customers who have flown Southwest, United Airlines, and American Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny
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Mesa and Des Moines flights
Browse other Mesa and Des Moines flight options. Last updated on February 13, 2026.
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Consider these flights traveling from Mesa to Des Moines.
Top 6 airlines flying from Mesa to Des Moines
Discover the top 6 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$67 | Average$190 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$135 | Average$208 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$164 | Average$307 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$220 | Average$378 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$222 | Average$363 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$275 | Average$383 | FlexibilityNo cancel fee | On-time69% |