$88+ Cheap flights from Mesa, AZ to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Aug 5 — Aug 121
Round-trip
1 adult, Economy
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Find cheap flights from Mesa to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in November or October, booked 65 days in advance, depart on a Wednesday or Monday and return on a Wednesday
Cheap flight deals from Mesa to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mesa to Des MoinesExplore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 6, 2026.
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/209:03 am
PHX
- DSM
1 stop9h 57m
Multiple Airlines
Mon 8/248:38 pm
DSM
- PHX
1 stop18h 21m
Multiple Airlines
Deal found 7/3![Multiple Airlines logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:45 am
PHX
- DSM
1 stop11h 09m
Multiple Airlines
Mon 8/1010:06 pm
DSM
- PHX
1 stop16h 53m
Multiple Airlines
Deal found 7/5![Multiple Airlines logo]()
$230
This Expedia deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:35 am
PHX
- DSM
1 stop4h 59m
Frontier
Mon 8/312:19 pm
DSM
- PHX
1 stop24h 58m
Frontier
Deal found 7/1![Frontier logo]()
$248
This CheapOair deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:36 pm
PHX
- DSM
1 stop16h 42m
Frontier
Wed 10/212:31 pm
DSM
- PHX
1 stop18h 40m
Frontier
Deal found 7/3![Frontier logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:45 am
PHX
- DSM
1 stop11h 09m
Multiple Airlines
Sun 8/169:44 pm
DSM
- PHX
1 stop15h 43m
Multiple Airlines
Deal found 7/2![Multiple Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3010:55 pm
PHX
- DSM
1 stop18h 31m
Multiple Airlines
Wed 10/72:42 pm
DSM
- PHX
1 stop8h 53m
Multiple Airlines
Deal found 7/5![Multiple Airlines logo]()
$258
This Expedia deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:35 am
PHX
- DSM
1 stop4h 59m
Frontier
Mon 8/312:19 pm
DSM
- PHX
1 stop21h 52m
Frontier
Deal found 7/2![Frontier logo]()
$259
This Expedia deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:35 am
PHX
- DSM
1 stop4h 59m
Frontier
Fri 8/282:19 pm
DSM
- PHX
1 stop19h 21m
Frontier
Deal found 7/5![Frontier logo]()
$264
This Trip.com deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:35 am
PHX
- DSM
1 stop26h 59m
Frontier
Mon 8/312:19 pm
DSM
- PHX
1 stop11h 20m
Frontier
Deal found 7/2![Frontier logo]()
$266
This Expedia deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/46:35 am
PHX
- DSM
1 stop4h 59m
Frontier
Mon 9/72:19 pm
DSM
- PHX
1 stop27h 24m
Frontier
Deal found 7/2![Frontier logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:53 pm
PHX
- DSM
1 stop16h 41m
Multiple Airlines
Mon 7/2710:01 pm
DSM
- PHX
2 stops21h 40m
Multiple Airlines
Deal found 7/4![Multiple Airlines logo]()
$273
Best flights from Mesa to Des MoinesDiscover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 6, 2026.
Discover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 6, 2026.
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:45 am
PHX
- DSM
1 stop7h 31m
Delta
Mon 8/246:55 am
DSM
- PHX
1 stop5h 57m
Delta
Deal found 7/1![Delta logo]()
$364
This Southwest deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:40 am
PHX
- DSM
2 stops8h 10m
Southwest
Fri 10/305:10 am
DSM
- PHX
2 stops8h 45m
Southwest
Deal found 7/2![Southwest logo]()
$379
This Delta deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/811:50 am
PHX
- DSM
1 stop6h 49m
Delta
Mon 8/102:45 pm
DSM
- PHX
1 stop7h 21m
Delta
Deal found 7/3![Delta logo]()
$387
This Southwest deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/132:20 pm
PHX
- DSM
1 stop4h 55m
Southwest
Tue 8/1812:30 pm
DSM
- PHX
1 stop5h 50m
Southwest
Deal found 7/2![Southwest logo]()
$390
This Southwest deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/222:30 pm
PHX
- DSM
1 stop4h 30m
Southwest
Wed 9/2312:30 pm
DSM
- PHX
1 stop7h 05m
Southwest
Deal found 7/5![Southwest logo]()
$397
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/610:40 am
PHX
- DSM
2 stops9h 30m
Southwest
Sat 8/84:50 pm
DSM
- PHX
1 stop5h 40m
Southwest
Deal found 7/1![Southwest logo]()
$410
This Southwest deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:20 pm
PHX
- DSM
1 stop4h 55m
Southwest
Wed 9/162:40 pm
DSM
- PHX
1 stop6h 20m
Southwest
Deal found 7/4![Southwest logo]()
$418
This Southwest deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/181:25 pm
PHX
- DSM
2 stops7h 25m
Southwest
Wed 10/215:35 am
DSM
- PHX
2 stops8h 05m
Southwest
Deal found 7/3![Southwest logo]()
$424
Last-minute flights from Mesa to Des MoinesDiscover last-minute flight deals from Mesa to Des Moines. Data last updated July 6, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to Des Moines. Data last updated July 6, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:53 pm
PHX
- DSM
1 stop16h 41m
Multiple Airlines
Mon 7/2710:01 pm
DSM
- PHX
2 stops21h 40m
Multiple Airlines
Deal found 7/4![Multiple Airlines logo]()
$273
This CheapOair deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2111:19 am
PHX
- DSM
1 stop24h 15m
Frontier
Mon 7/272:19 pm
DSM
- PHX
1 stop9h 09m
Frontier
Deal found 7/4![Frontier logo]()
$279
This CheapOair deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/234:48 pm
PHX
- DSM
1 stop18h 46m
Frontier
Mon 7/272:19 pm
DSM
- PHX
1 stop24h 58m
Frontier
Deal found 7/1![Frontier logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:45 am
PHX
- DSM
1 stop11h 09m
Multiple Airlines
Mon 8/1010:06 pm
DSM
- PHX
1 stop16h 53m
Multiple Airlines
Deal found 7/5![Multiple Airlines logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:45 am
PHX
- DSM
1 stop11h 09m
Multiple Airlines
Sun 8/169:44 pm
DSM
- PHX
1 stop15h 43m
Multiple Airlines
Deal found 7/2![Multiple Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/209:03 am
PHX
- DSM
1 stop9h 57m
Multiple Airlines
Mon 8/248:38 pm
DSM
- PHX
1 stop18h 21m
Multiple Airlines
Deal found 7/3![Multiple Airlines logo]()
$208
This Expedia deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:35 am
PHX
- DSM
1 stop4h 59m
Frontier
Mon 8/312:19 pm
DSM
- PHX
1 stop21h 52m
Frontier
Deal found 7/2![Frontier logo]()
$259
This Expedia deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:35 am
PHX
- DSM
1 stop4h 59m
Frontier
Mon 8/312:19 pm
DSM
- PHX
1 stop24h 58m
Frontier
Deal found 7/1![Frontier logo]()
$248
This Expedia deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:35 am
PHX
- DSM
1 stop4h 59m
Frontier
Fri 8/282:19 pm
DSM
- PHX
1 stop19h 21m
Frontier
Deal found 7/5![Frontier logo]()
$264
This Trip.com deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:35 am
PHX
- DSM
1 stop26h 59m
Frontier
Mon 8/312:19 pm
DSM
- PHX
1 stop11h 20m
Frontier
Deal found 7/2![Frontier logo]()
$266
One-way flights from Mesa to Des MoinesSearch for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated July 6, 2026.
Search for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated July 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2910:55 pm
PHX
- DSM
1 stop12h 57m
Multiple Airlines
Deal found 7/2![Multiple Airlines logo]()
$88
This Kiwi.com deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/610:55 pm
PHX
- DSM
1 stop12h 57m
Multiple Airlines
Deal found 7/6![Multiple Airlines logo]()
$94
This Kiwi.com deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3010:55 pm
PHX
- DSM
1 stop18h 31m
Multiple Airlines
Deal found 7/2![Multiple Airlines logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/32:16 pm
PHX
- DSM
2 stops44h 43m
Multiple Airlines
Deal found 7/4![Multiple Airlines logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1310:40 pm
PHX
- DSM
1 stop13h 12m
Multiple Airlines
Deal found 7/5![Multiple Airlines logo]()
$115
This CheapOair deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/411:19 am
PHX
- DSM
1 stop24h 15m
Frontier
Deal found 7/5![Frontier logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:09 pm
PHX
- DSM
1 stop21h 02m
Multiple Airlines
Deal found 7/3![Multiple Airlines logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/812:49 pm
PHX
- DSM
1 stop7h 12m
Multiple Airlines
Deal found 7/6![Multiple Airlines logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:55 pm
PHX
- DSM
1 stop15h 02m
Multiple Airlines
Deal found 7/2![Multiple Airlines logo]()
$120
This Frontier deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:35 am
PHX
- DSM
1 stop4h 59m
Frontier
Deal found 7/2![Frontier logo]()
$124
Find flight deals from Mesa to Des Moines
Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated July 6, 2026.
Round-trip from | $208 (Kiwi.com) |
|---|---|
One-way from | $88 (Kiwi.com) |
Popular in | July |
Cheapest in | November |
Average price | $429 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 6, 2026.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 8/22
5:45 am-3:16 pm
1 stop7h 31m
Des Moines
Mon 8/24
6:55 am-10:52 am
1 stop5h 57m
$364
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Wed 10/28
7:40 am-5:50 pm
2 stops8h 10m
Des Moines
Fri 10/30
5:10 am-11:55 am
2 stops8h 45m
$379
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 8/8
11:50 am-8:39 pm
1 stop6h 49m
Des Moines
Mon 8/10
2:45 pm-8:06 pm
1 stop7h 21m
$387
Quickest round-trip
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 8/13
2:20 pm-9:15 pm
1 stop4h 55m
Des Moines
Tue 8/18
12:30 pm-4:20 pm
1 stop5h 50m
$390
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 9/22
2:30 pm-9:00 pm
1 stop4h 30m
Des Moines
Wed 9/23
12:30 pm-5:35 pm
1 stop7h 05m
$397
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 8/6
10:40 am-10:10 pm
2 stops9h 30m
Des Moines
Sat 8/8
4:50 pm-8:30 pm
1 stop5h 40m
$410
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 9/10
2:20 pm-9:15 pm
1 stop4h 55m
Des Moines
Wed 9/16
2:40 pm-7:00 pm
1 stop6h 20m
$418
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sun 10/18
1:25 pm-10:50 pm
2 stops7h 25m
Des Moines
Wed 10/21
5:35 am-11:40 am
2 stops8h 05m
$424
Cheapest one-way
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 9/3
9:03 am-11:10 am
1 stop24h 07m
$120
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 9/1
6:20 am-1:55 pm
1 stop5h 35m
$194
Showing 1-10 of 18 resultsSorted by cheapest first
Best time to book a flight from Mesa to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
PHX-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Des Moines
MS9-DSM
PHX-DSM
What is the cheapest time of day to fly from MS9 to DSM?
Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 6, 2026.
It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 30% on the flight price compared to flying in the afternoon, which is usually more expensive.
How much does it cost to fly round-trip from Mesa to Des Moines?
What is the cheapest day to fly from Mesa to Des Moines?
Use this chart to determine the cheapest time to fly round-trip from Mesa to Des Moines. Price data was last updated on June 27, 2026.
Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Saturday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated July 6, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAmerican Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Ames
Clive
Johnston
Boone
West Des Moines
Ankeny
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Top 5 airlines flying from Mesa to Des Moines
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$118 | Average$228 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$142 | Average$246 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$232 | Average$411 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$265 | Average$406 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$275 | Average$376 | FlexibilityNo cancel fee | On-time69% |