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Des Moines

$85+ Cheap flights from Mesa, AZ to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/12. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
אפר' 23 — אפר' 301
ה' 4/23
ה' 4/30
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in November or May, booked 65 days in advance, depart on a Tuesday or Saturday and return on a Wednesday

Cheap flight deals from Mesa to Des Moines

Cheapest flights from Mesa to Des Moines
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on מרץ 24, 2026.

This Expedia deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ג' 5/126:53 pm
PHX
-
DSM
1 stop16h 38m
Frontier
ד' 5/202:16 pm
DSM
-
PHX
1 stop19h 28m
Frontier
Deal found 3/24$180
This Expedia deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ו' 4/176:50 am
PHX
-
DSM
1 stop4h 19m
Frontier
ב' 4/202:04 pm
DSM
-
PHX
1 stop8h 12m
Frontier
Deal found 3/20$201
This Frontier deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ב' 5/185:15 am
PHX
-
DSM
1 stop6h 16m
Frontier
ו' 5/292:16 pm
DSM
-
PHX
1 stop8h 54m
Frontier
Deal found 3/23$221
This Southwest deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ג' 5/196:10 am
PHX
-
DSM
1 stop5h 55m
Southwest
ג' 5/193:15 pm
DSM
-
PHX
1 stop7h 25m
Southwest
Deal found 3/22$230
This Super.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ה' 4/1612:50 pm
PHX
-
DSM
1 stop22h 19m
Frontier
ב' 4/202:04 pm
DSM
-
PHX
1 stop8h 12m
Frontier
Deal found 3/21$231
This Frontier deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ו' 4/36:50 am
PHX
-
DSM
1 stop10h 24m
Frontier
ב' 4/68:14 pm
DSM
-
PHX
1 stop5h 43m
Frontier
Deal found 3/20$235
This Expedia deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ו' 4/176:50 am
PHX
-
DSM
1 stop4h 19m
Frontier
ו' 4/242:04 pm
DSM
-
PHX
1 stop23h 41m
Frontier
Deal found 3/20$242
This Frontier deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ו' 4/246:50 am
PHX
-
DSM
1 stop4h 19m
Frontier
ב' 4/272:04 pm
DSM
-
PHX
1 stop5h 43m
Frontier
Deal found 3/24$245
This Orbitz deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ו' 8/145:15 am
PHX
-
DSM
1 stop6h 16m
Frontier
ב' 8/172:16 pm
DSM
-
PHX
1 stop11h 18m
Frontier
Deal found 3/19$250
This CheapOair deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ה' 4/236:51 pm
PHX
-
DSM
1 stop16h 18m
Frontier
ב' 4/272:04 pm
DSM
-
PHX
1 stop8h 12m
Frontier
Deal found 3/23$256

Find flight deals from Mesa to Des Moines

Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated מרץ 24, 2026.

Round-trip from

$180
(Expedia)

One-way from

$85
(Super.com)

Popular in

July

Cheapest in

November

Average price

$393
From Mesa to Des Moines
Search Deals
One-way flight from Mesa to Des Moines
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($6 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($4 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated מרץ 24, 2026.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

ד' 4/29

1:40 pm-9:15 pm

1 stop5h 35m

Des Moines

א' 5/3

12:00 pm-1:00 pm

Nonstop3h 00m

$325

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

ג' 5/19

7:15 am-2:05 pm

1 stop4h 50m

Des Moines

ג' 5/19

3:15 pm-9:40 pm

2 stops8h 25m

$330

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

ג' 5/12

11:10 am-9:15 pm

2 stops8h 05m

Des Moines

ד' 5/20

6:55 am-1:55 pm

2 stops9h 00m

$335
Quickest round-trip

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

ו' 4/24

1:55 pm-6:35 pm

Nonstop2h 40m

Des Moines

ב' 4/27

1:45 pm-2:40 pm

Nonstop2h 55m

$361

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

ש' 4/11

7:45 am-6:00 pm

1 stop8h 15m

Des Moines

ב' 4/13

1:45 pm-2:40 pm

Nonstop2h 55m

$391

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

ה' 7/16

6:40 am-4:00 pm

1 stop7h 20m

Des Moines

ד' 7/29

5:20 am-2:35 pm

2 stops11h 15m

$395

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

ב' 5/11

1:55 pm-6:35 pm

Nonstop2h 40m

Des Moines

ו' 5/29

4:20 pm-9:25 pm

1 stop7h 05m

$409

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

ד' 5/27

12:59 am-10:16 am

1 stop7h 17m

Des Moines

א' 5/31

5:28 pm-11:29 pm

1 stop8h 01m

$429

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

ו' 5/15

7:05 pm-10:37 am

2 stops13h 32m

Des Moines

ב' 5/18

7:05 pm-11:53 pm

1 stop6h 48m

$457
Cheapest one-way

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

ד' 4/22

11:35 am-9:15 pm

2 stops7h 40m

$120

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/22

Showing 1-10 of 21 resultsSorted by cheapest first
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2
3

Best time to book a flight from Mesa to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Des Moines

How far ahead should I book a flight from Mesa to Des Moines?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Des Moines. Price data was last updated on March 13, 2026.

The price you pay for your flight from Mesa to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 64 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Des Moines?

Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in April is currently the most expensive (average of $198). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to DSM?

Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated מרץ 24, 2026.

It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 27% on the flight price compared to flying in the morning, which is usually more expensive.

Weekly flight availability from Mesa to Des Moines

Explore weekly flight availability from Mesa to Des Moines. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated מרץ 24, 2026.

The most flights from MS9 to DSM are scheduled on a Monday (9 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (4 on average).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated מרץ 24, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAllegiant Air from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,331 reviews

Comfort

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,331 reviews
Southwest
8.0
Very good
4,331 reviews

Comfort

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
United Airlines
7.4
Good
9,470 reviews
Southwest
8.0
Very good
4,331 reviews

Comfort

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Allegiant Air
7.3
Good
710 reviews
Southwest
8.0
Very good
4,331 reviews

Comfort

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,491 reviews
Southwest
8.0
Very good
4,331 reviews

Comfort

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Frontier
5.7
Fair
3,018 reviews
Southwest
8.0
Very good
4,331 reviews

Comfort

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mesa?

    For a flight from Mesa to Des Moines, you will be flying into Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 7 inbound flights from Mesa per day. 6 airlines have flights to Des Moines from Mesa on a regular basis.

  • How long is the flight from Mesa to Des Moines?

    Southwest and United Airlines can get you from Mesa to Des Moines in just under 4h 54m. Your travel time can differ by up to 41m. Mesa and Des Moines are separated by a distance of 1147 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Mesa to Des Moines one-way?

    One-way options have recently been found by users for as low as $61 on Allegiant Air. Other airlines that offer cheap prices include Frontier from $65 and American Airlines from $89 one-way.

  • What are the most reliable airlines from Mesa to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mesa to Des Moines on time: Frontier (100%), Volaris (100%), Southwest (86%).

  • What are the cheapest flights from Mesa to Des Moines?

    While on average a flight from Mesa to Des Moines is generally $318, our data shows the cheapest flight currently is $143. When looking at the most popular route, (Phoenix Sky Harbor Intl - Des Moines), you can expect to pay $227 for that flight.

  • Can I find deals for flights from Mesa to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mesa to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Des Moines.

  • Can I find deals for business class flights from Mesa to Des Moines?

    Yes. Cheapflights offers flight deals from Mesa to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Des Moines?

    Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in April is currently the most expensive (average of $198). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ankeny
Ames
Boone
Clive
West Des Moines

Browse thousands of different options on Cheapflights for your next trip

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Top 6 airlines flying from Mesa to Des Moines

Discover the top 6 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated מרץ 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$67Average$186FlexibilityNo cancel feeOn-time88%
FrontierCheapest$137Average$208FlexibilityNo cancel feeOn-time62%
DeltaCheapest$164Average$288FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$208Average$365FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$222Average$385FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$275Average$376FlexibilityNo cancel feeOn-time69%

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