HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$73+ Cheap flights from Mesa, AZ to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Mesa to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in April or February, booked 77 days in advance, depart on a Tuesday or Saturday and return on a Tuesday

Cheap flight deals from Mesa to Des Moines

Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated August 14, 2025.

Round-trip from

$160
(FlightHub)

One-way from

$73
(Priceline)

Popular in

January

Cheapest in

April

Average price

$352
From Mesa to Des Moines
Search Deals
One-way flight from Mesa to Des Moines
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($26 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
Search Deals

Find flight deals from Mesa to Des Moines

Cheapest flights from Mesa to Des Moines
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This FlightHub deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3112:00 pmPHX - DSM
1 stop5h 59mFrontier
Sun 11/28:44 pmDSM - PHX
1 stop4h 45mFrontier
Deal found 8/14$160
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/294:20 pmPHX - DSM
Nonstop2h 56mAmerican Airlines
Sat 11/12:28 pmDSM - PHX
Nonstop3h 07mAmerican Airlines
Deal found 8/11$201
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/175:30 amPHX - DSM
1 stop7h 10mSouthwest
Wed 10/16:30 amDSM - PHX
1 stop5h 35mSouthwest
Deal found 8/12$220
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/17:15 pmPHX - DSM
Nonstop2h 59mAmerican Airlines
Fri 9/52:17 pmDSM - PHX
Nonstop3h 18mAmerican Airlines
Deal found 8/11$222
This Priceline deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/3012:00 pmPHX - DSM
1 stop5h 59mFrontier
Sun 11/28:44 pmDSM - PHX
1 stop4h 45mFrontier
Deal found 8/11$224
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/175:30 amPHX - DSM
1 stop7h 10mSouthwest
Tue 9/308:25 amDSM - PHX
2 stops9h 20mSouthwest
Deal found 8/12$229
This Priceline deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/177:21 amPHX - DSM
1 stop4h 31mFrontier
Mon 10/202:39 pmDSM - PHX
1 stop5h 42mFrontier
Deal found 8/12$230
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/37:22 pmPHX - DSM
Nonstop2h 56mAmerican Airlines
Wed 9/102:17 pmDSM - PHX
Nonstop3h 18mAmerican Airlines
Deal found 8/12$231
This FlightHub deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/46:32 amPHX - DSM
1 stop5h 08mFrontier
Sun 9/72:25 pmDSM - PHX
1 stop19h 07mFrontier
Deal found 8/12$233
This FlightHub deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/312:11 pmPHX - DSM
1 stop23h 29mFrontier
Sun 9/72:25 pmDSM - PHX
1 stop19h 07mFrontier
Deal found 8/12$235
This SmartFares deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:32 amPHX - DSM
1 stop5h 08mFrontier
Mon 9/292:25 pmDSM - PHX
1 stop7h 00mFrontier
Deal found 8/12$236
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/31:37 pmPHX - DSM
1 stop7h 06mDelta
Wed 9/103:30 pmDSM - PHX
1 stop9h 11mDelta
Deal found 8/12$237

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.

Fly from

Mesa

Fly to

Des Moines

Route

Depart

Return

Price

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Fri 10/31

12:00 pm-7:59 pm

1 stop5h 59m

Des Moines

Sun 11/2

8:44 pm-12:29 am

1 stop4h 45m

$160

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 10/29

4:20 pm-9:16 pm

Nonstop2h 56m

Des Moines

Sat 11/1

2:28 pm-3:35 pm

Nonstop3h 07m

$201

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 9/17

5:30 am-2:40 pm

1 stop7h 10m

Des Moines

Wed 10/1

6:30 am-10:05 am

1 stop5h 35m

$220

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 9/17

5:30 am-2:40 pm

1 stop7h 10m

Des Moines

Tue 9/30

3:25 pm-7:25 pm

1 stop6h 00m

$220

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 9/10

7:22 pm-12:18 am

Nonstop2h 56m

Des Moines

Fri 9/12

2:17 pm-3:35 pm

Nonstop3h 18m

$222

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Mon 9/1

7:15 pm-12:14 am

Nonstop2h 59m

Des Moines

Fri 9/5

2:17 pm-3:35 pm

Nonstop3h 18m

$222

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 10/30

12:00 pm-7:59 pm

1 stop5h 59m

Des Moines

Sun 11/2

8:44 pm-12:29 am

1 stop4h 45m

$224

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Fri 10/17

7:21 am-1:52 pm

1 stop4h 31m

Des Moines

Mon 10/20

2:39 pm-6:21 pm

1 stop5h 42m

$230

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 9/3

7:22 pm-12:18 am

Nonstop2h 56m

Des Moines

Wed 9/10

2:17 pm-3:35 pm

Nonstop3h 18m

$231

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 9/10

12:39 pm-1:40 pm

1 stop23h 01m

Des Moines

Fri 9/12

2:25 pm-8:59 am

1 stop20h 34m

$231

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Showing 1-10 of 22 results
1
2
3

Best time to book a flight from Mesa to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Des Moines

How far ahead should I book a flight from Mesa to Des Moines?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Des Moines. Price data was last updated on August 8, 2025.

The price you pay for your flight from Mesa to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 77 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $336). Flying from Mesa to Des Moines in June is currently the most expensive (average of $401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to DSM?

Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

When flying from Mesa to Des Moines, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Mesa to Des Moines?

Use this chart to determine the cheapest time to fly round-trip from Mesa to Des Moines. Price data was last updated on August 10, 2025.

Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Saturday afternoons when fares are most often at their lowest. Wednesday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Mesa to Des Moines

Explore weekly flight availability from Mesa to Des Moines. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 14, 2025.

The most flights from MS9 to DSM are scheduled on a Thursday (6 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (4 on average).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated August 14, 2025.
Read reviews from past customers who have flown Southwest, Delta, and American Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,244 reviews
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
8.0
Very good
7,980 reviews
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Allegiant Air
7.2
Good
701 reviews
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Frontier
5.8
Fair
3,217 reviews
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mesa?

    For a flight from Mesa to Des Moines, you will be flying into Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 4 inbound flights from Mesa per day. 6 airlines have flights to Des Moines from Mesa on a regular basis.

  • What are the most reliable airlines from Mesa to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mesa to Des Moines on time: Envoy Air (100%), SkyWest Airlines (97%), Alaska Airlines (93%).

  • What are the cheapest flights from Mesa to Des Moines?

    While on average a flight from Mesa to Des Moines is generally $309, our data shows the cheapest flight currently is $125. When looking at the most popular route, (Phoenix Sky Harbor Intl - Des Moines), you can expect to pay $157 for that flight.

  • Can I find deals for flights from Mesa to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mesa to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Des Moines.

  • Can I find deals for business class flights from Mesa to Des Moines?

    Yes. Cheapflights offers flight deals from Mesa to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $336). Flying from Mesa to Des Moines in June is currently the most expensive (average of $401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mesa to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
Sky Harbor Intl to Des Moines flights
Sky Harbor Intl to Cedar Rapids flights
Sky Harbor Intl to Omaha flights
Las Vegas to Omaha flights
Sky Harbor Intl to Moline flights
Las Vegas to Des Moines flights
Tucson to Omaha flights
Tucson to Moline flights
Tucson to Des Moines flights
Las Vegas to Cedar Rapids flights
Tucson to Cedar Rapids flights
Phoenix-Mesa Gateway to Des Moines flights
Sky Harbor Intl to Sioux City flights
Flagstaff to Omaha flights
Sky Harbor Intl to Waterloo flights
Las Vegas to Moline flights
Yuma to Des Moines flights
Sky Harbor Intl to La Crosse flights
Sky Harbor Intl to Burlington flights
Tucson to Sioux City flights
Sky Harbor Intl to Dubuque flights
Yuma to Omaha flights
Tucson to La Crosse flights
Tucson to Waterloo flights
Las Vegas to Burlington flights
Flagstaff to Cedar Rapids flights

Top 6 airlines flying from Mesa to Des Moines

Discover the top 6 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$112Average$208FlexibilityNo cancel feeOn-time88%
FrontierCheapest$135Average$209FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$211Average$379FlexibilityNo cancel feeOn-time71%
DeltaCheapest$216Average$288FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$218Average$374FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$275Average$462FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.