$83+ Cheap flights from Mesa, AZ to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/4. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Jul 20 — Jul 271
Round-trip
1 adult, Economy
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Find cheap flights from Mesa to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in November or October, booked 65 days in advance, depart on a Saturday or Wednesday and return on a Wednesday
Cheap flight deals from Mesa to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mesa to Des MoinesExplore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 20, 2026.
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Mon 8/1010:06 pm
DSM
- PHX
1 stop16h 53m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$167
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/59:58 pm
PHX
- DSM
1 stop20h 56m
Multiple Airlines
Mon 8/1010:06 pm
DSM
- PHX
1 stop16h 53m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Fri 8/79:21 pm
DSM
- PHX
1 stop16h 06m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:27 pm
PHX
- DSM
1 stop18h 21m
Multiple Airlines
Mon 8/318:54 pm
DSM
- PHX
1 stop18h 05m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:45 am
PHX
- DSM
1 stop11h 09m
Multiple Airlines
Mon 8/1010:06 pm
DSM
- PHX
1 stop16h 53m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/77:45 am
PHX
- DSM
1 stop10h 46m
Multiple Airlines
Mon 8/1010:06 pm
DSM
- PHX
1 stop16h 53m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Thu 8/139:44 pm
DSM
- PHX
1 stop15h 43m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/152:04 pm
PHX
- DSM
1 stop28h 39m
Multiple Airlines
Wed 7/291:49 pm
DSM
- PHX
1 stop11h 16m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/59:58 pm
PHX
- DSM
1 stop20h 56m
Multiple Airlines
Thu 8/139:44 pm
DSM
- PHX
1 stop15h 43m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:45 am
PHX
- DSM
1 stop9h 03m
Multiple Airlines
Mon 8/248:38 pm
DSM
- PHX
1 stop16h 46m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/69:58 pm
PHX
- DSM
1 stop20h 33m
Multiple Airlines
Fri 8/1410:06 pm
DSM
- PHX
1 stop15h 21m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$245
Best flights from Mesa to Des MoinesDiscover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 20, 2026.
Discover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/177:45 am
PHX
- DSM
1 stop11h 26m
Multiple Airlines
Mon 7/2010:01 pm
DSM
- PHX
1 stop27h 04m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$255
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2311:04 pm
PHX
- DSM
1 stop8h 41m
Delta
Tue 7/2810:25 am
DSM
- PHX
1 stop9h 30m
Delta
Deal found 6/15![Delta logo]()
$390
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2011:20 am
PHX
- DSM
2 stops9h 05m
Southwest
Sat 8/153:05 pm
DSM
- PHX
1 stop6h 55m
Southwest
Deal found 6/18![Southwest logo]()
$395
This United Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/259:23 am
PHX
- DSM
1 stop4h 56m
United Airlines
Wed 8/265:21 pm
DSM
- PHX
1 stop6h 48m
United Airlines
Deal found 6/19![United Airlines logo]()
$431
This Delta deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/111:04 pm
PHX
- DSM
1 stop8h 41m
Delta
Fri 8/76:00 am
DSM
- PHX
1 stop9h 50m
Delta
Deal found 6/18![Delta logo]()
$418
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/11:05 pm
PHX
- DSM
2 stops6h 55m
Southwest
Mon 8/31:30 pm
DSM
- PHX
1 stop6h 45m
Southwest
Deal found 6/17![Southwest logo]()
$438
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1311:25 am
PHX
- DSM
2 stops7h 50m
Southwest
Mon 8/175:40 am
DSM
- PHX
2 stops8h 10m
Southwest
Deal found 6/15![Southwest logo]()
$438
This Delta deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/911:10 pm
PHX
- DSM
1 stop8h 14m
Delta
Sun 10/117:50 pm
DSM
- PHX
1 stop5h 24m
Delta
Deal found 6/18![Delta logo]()
$439
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:30 pm
PHX
- DSM
1 stop6h 40m
Southwest
Mon 9/75:40 am
DSM
- PHX
2 stops8h 10m
Southwest
Deal found 6/18![Southwest logo]()
$444
Last-minute flights from Mesa to Des MoinesDiscover last-minute flight deals from Mesa to Des Moines. Data last updated June 20, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to Des Moines. Data last updated June 20, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:45 am
PHX
- DSM
1 stop11h 26m
Multiple Airlines
Mon 7/610:01 pm
DSM
- PHX
1 stop16h 58m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$299
This Orbitz deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/72:15 pm
PHX
- DSM
1 stop21h 19m
Frontier
Fri 7/102:19 pm
DSM
- PHX
1 stop27h 24m
Frontier
Deal found 6/15![Frontier logo]()
$250
This Expedia deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:40 am
PHX
- DSM
1 stop4h 54m
Frontier
Fri 7/242:19 pm
DSM
- PHX
1 stop11h 13m
Frontier
Deal found 6/19![Frontier logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/152:04 pm
PHX
- DSM
1 stop28h 39m
Multiple Airlines
Wed 7/291:49 pm
DSM
- PHX
1 stop11h 16m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/177:45 am
PHX
- DSM
1 stop11h 26m
Multiple Airlines
Mon 7/2010:01 pm
DSM
- PHX
1 stop16h 58m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$246
This Expedia deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:40 am
PHX
- DSM
1 stop4h 54m
Frontier
Mon 7/202:19 pm
DSM
- PHX
1 stop11h 13m
Frontier
Deal found 6/18![Frontier logo]()
$269
One-way flights from Mesa to Des MoinesSearch for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 20, 2026.
Search for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$83
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:55 pm
PHX
- DSM
1 stop20h 11m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$89
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/219:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$91
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/159:58 pm
PHX
- DSM
1 stop20h 45m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$96
This Trip.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/282:04 pm
PHX
- DSM
1 stop20h 55m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/79:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1811:21 am
PHX
- DSM
1 stop24h 10m
Frontier
Deal found 6/19![Frontier logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:11 pm
PHX
- DSM
2 stops24h 37m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$109
Find flight deals from Mesa to Des Moines
Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated June 20, 2026.
Round-trip from | $167 (Kiwi.com) |
|---|---|
One-way from | $83 (Kiwi.com) |
Popular in | December |
Cheapest in | November |
Average price | $408 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 20, 2026.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Fri 7/17
7:45 am-9:11 pm
1 stop11h 26m
Des Moines
Mon 7/20
10:01 pm-11:05 pm
1 stop27h 04m
$255
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 7/23
11:04 pm-9:45 am
1 stop8h 41m
Des Moines
Tue 7/28
10:25 am-5:55 pm
1 stop9h 30m
$390
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Mon 7/20
11:20 am-10:25 pm
2 stops9h 05m
Des Moines
Sat 8/15
3:05 pm-8:00 pm
1 stop6h 55m
$395
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 8/1
11:04 pm-9:45 am
1 stop8h 41m
Des Moines
Fri 8/7
6:00 am-1:50 pm
1 stop9h 50m
$418
Quickest round-trip
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 8/25
9:23 am-4:19 pm
1 stop4h 56m
Des Moines
Wed 8/26
5:21 pm-10:09 pm
1 stop6h 48m
$431
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 8/1
1:05 pm-10:00 pm
2 stops6h 55m
Des Moines
Mon 8/3
1:30 pm-6:15 pm
1 stop6h 45m
$438
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 8/13
11:25 am-9:15 pm
2 stops7h 50m
Des Moines
Mon 8/17
5:40 am-11:50 am
2 stops8h 10m
$438
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Fri 10/9
11:10 pm-9:24 am
1 stop8h 14m
Des Moines
Sun 10/11
7:50 pm-11:14 pm
1 stop5h 24m
$439
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Fri 9/4
1:30 pm-10:10 pm
1 stop6h 40m
Des Moines
Mon 9/7
5:40 am-11:50 am
2 stops8h 10m
$444
Cheapest one-way
Quickest one-way
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Fri 7/24
6:40 am-1:34 pm
1 stop4h 54m
$144
Showing 1-10 of 20 resultsSorted by cheapest first
Best time to book a flight from Mesa to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
PHX-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Des Moines
MS9-DSM
PHX-DSM
What is the cheapest time of day to fly from MS9 to DSM?
Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 20, 2026.
It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 29% on the flight price compared to flying in the afternoon, which is usually more expensive.
How much does it cost to fly round-trip from Mesa to Des Moines?
What is the cheapest day to fly from Mesa to Des Moines?
Use this chart to determine the cheapest time to fly round-trip from Mesa to Des Moines. Price data was last updated on June 13, 2026.
Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Saturday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated June 20, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAmerican Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Entertainment
7.5
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Entertainment
7.5
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Entertainment
7.5
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Entertainment
7.5
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Related info for your journey
Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Ames
Clive
Johnston
Boone
West Des Moines
Ankeny
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Mesa and Des Moines flights
Browse other Mesa and Des Moines flight options. Last updated on June 20, 2026.
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Mesa to Des Moines flights
Consider these flights traveling from Mesa to Des Moines.
Top 5 airlines flying from Mesa to Des Moines
Discover the top 5 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$118 | Average$228 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$128 | Average$230 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$239 | Average$415 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$248 | Average$402 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$275 | Average$376 | FlexibilityNo cancel fee | On-time69% |