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Des Moines

$68+ Cheap flights from Mesa, AZ to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/14. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Feb 5 — Feb 121
Thu 2/5
Thu 2/12
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in April or February, booked 79 days in advance, depart on a Tuesday or Saturday and return on a Wednesday

Cheap flight deals from Mesa to Des Moines

Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated January 6, 2026.

Round-trip from

$152
(Priceline)

One-way from

$68
(Priceline)

Popular in

January

Cheapest in

April

Average price

$651
From Mesa to Des Moines
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One-way flight from Mesa to Des Moines
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Highest demand for flights based on searches. 16% potential increase in price ($71 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($26 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Mesa to Des Moines

Cheapest flights from Mesa to Des Moines
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 6, 2026.

This Frontier deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:30 amPHX - DSM
Nonstop2h 41mFrontier
Sat 3/212:56 pmDSM - PHX
Nonstop3h 20mFrontier
Deal found 1/3$129
This Kiwi.com deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:51 pmPHX - DSM
1 stop22h 56mFrontier
Sun 2/227:45 pmDSM - PHX
1 stop5h 56mFrontier
Deal found 1/3$144
This Priceline deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:30 amPHX - DSM
Nonstop2h 41mFrontier
Fri 3/204:43 pmDSM - PHX
Nonstop3h 20mFrontier
Deal found 1/4$152
This Super.com deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/256:51 pmPHX - DSM
1 stop22h 51mFrontier
Mon 3/27:17 pmDSM - PHX
1 stop6h 24mFrontier
Deal found 1/5$156
This Frontier deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:30 amPHX - DSM
Nonstop2h 41mFrontier
Wed 3/185:41 pmDSM - PHX
Nonstop3h 20mFrontier
Deal found 1/3$162
This Kiwi.com deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/276:00 amPHX - DSM
1 stop12h 04mFrontier
Sun 3/17:27 pmDSM - PHX
1 stop16h 49mFrontier
Deal found 1/4$171
This Frontier deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/269:17 amPHX - DSM
1 stop8h 25mFrontier
Mon 3/27:17 pmDSM - PHX
1 stop6h 24mFrontier
Deal found 1/5$180
This Trip.com deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/236:00 amPHX - DSM
1 stop11h 32mFrontier
Thu 2/267:27 pmDSM - PHX
1 stop6h 14mFrontier
Deal found 1/5$207

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 6, 2026.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.

Fly from

Mesa

Fly to

Des Moines

Route

Depart

Return

Price

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 2/18

6:51 pm-6:47 pm

1 stop22h 56m

Des Moines

Sun 2/22

7:45 pm-12:41 am

1 stop5h 56m

$144

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 2/25

6:51 pm-6:42 pm

1 stop22h 51m

Des Moines

Mon 3/2

7:17 pm-12:41 am

1 stop6h 24m

$156

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 2/26

9:17 am-6:42 pm

1 stop8h 25m

Des Moines

Mon 3/2

7:17 pm-12:41 am

1 stop6h 24m

$180

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Sat 3/14

9:30 am-2:11 pm

Nonstop2h 41m

Des Moines

Thu 3/19

10:40 am-11:44 pm

1 stop15h 04m

$208

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Sat 1/31

4:45 pm-8:20 pm

Nonstop2h 35m

Des Moines

Tue 2/3

12:05 pm-5:40 pm

1 stop6h 35m

$217

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Sat 3/14

9:30 am-2:11 pm

Nonstop2h 41m

Des Moines

Sat 3/21

8:21 pm-11:51 pm

1 stop5h 30m

$217

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 2/5

9:55 am-1:40 pm

Nonstop2h 45m

Des Moines

Sat 2/7

3:35 pm-5:50 pm

Nonstop3h 15m

$227

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Sat 3/14

9:30 am-2:11 pm

Nonstop2h 41m

Des Moines

Sun 3/22

10:40 am-11:44 pm

1 stop15h 04m

$238

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 2/25

1:54 pm-5:43 pm

Nonstop2h 49m

Des Moines

Mon 3/2

6:23 pm-8:35 pm

Nonstop3h 12m

$239

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 3/4

6:51 pm-6:42 pm

1 stop22h 51m

$70

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/5

Showing 1-10 of 18 results
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Best time to book a flight from Mesa to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Des Moines

How far ahead should I book a flight from Mesa to Des Moines?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Des Moines. Price data was last updated on January 2, 2026.

The price you pay for your flight from Mesa to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 78 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Des Moines?

Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in March is currently the most expensive (average of $244). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to DSM?

Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 6, 2026.

It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 26% on the flight price compared to flying in the morning, which is usually more expensive.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated January 6, 2026.
Read reviews from past customers who have flown Southwest, United Airlines, and American Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,249 reviews

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,249 reviews
Southwest
8.0
Very good
4,249 reviews

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,138 reviews
Southwest
8.0
Very good
4,249 reviews

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,088 reviews
Southwest
8.0
Very good
4,249 reviews

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Allegiant Air
7.2
Good
702 reviews
Southwest
8.0
Very good
4,249 reviews

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Frontier
5.7
Fair
3,063 reviews
Southwest
8.0
Very good
4,249 reviews

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mesa?

    For a flight from Mesa to Des Moines, you will be flying into Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 3 inbound flights from Mesa per day. 6 airlines have flights to Des Moines from Mesa on a regular basis.

  • How long is the flight from Mesa to Des Moines?

    Frontier can get you from Mesa to Des Moines in just under 22h 56m. Your travel time can differ by up to . Mesa and Des Moines are separated by a distance of 1147 mi.

  • What are the cheapest airlines to fly from Mesa to Des Moines one-way?

    One-way options have recently been found by users for as low as $70 on Allegiant Air. Other airlines that offer cheap prices include Frontier from $79 and American Airlines from $89 one-way.

  • What are the most reliable airlines from Mesa to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mesa to Des Moines on time: SkyWest Airlines (75%), American Airlines (66%), Alaska Airlines (64%).

  • What are the cheapest flights from Mesa to Des Moines?

    While on average a flight from Mesa to Des Moines is generally $305, our data shows the cheapest flight currently is $86. When looking at the most popular route, (Phoenix Sky Harbor Intl - Des Moines), you can expect to pay $198 for that flight.

  • Can I find deals for flights from Mesa to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mesa to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Des Moines.

  • Can I find deals for business class flights from Mesa to Des Moines?

    Yes. Cheapflights offers flight deals from Mesa to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Des Moines?

    Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in March is currently the most expensive (average of $244). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

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Top 6 airlines flying from Mesa to Des Moines

Discover the top 6 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 6, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$112Average$204FlexibilityNo cancel feeOn-time88%
FrontierCheapest$135Average$208FlexibilityNo cancel feeOn-time62%
DeltaCheapest$190Average$307FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$222Average$352FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$224Average$380FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$275Average$407FlexibilityNo cancel feeOn-time69%

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