$100+ Cheap flights from Mesa, AZ to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/1. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
May 7 — May 141
Round-trip
1 adult, Economy
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Find cheap flights from Mesa to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in November or May, booked 65 days in advance, depart on a Tuesday or Wednesday and return on a Wednesday
Cheap flight deals from Mesa to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mesa to Des MoinesExplore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 7, 2026.
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 7, 2026.
This Trip.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:24 pm
PHX
- DSM
1 stop13h 45m
Frontier
Mon 5/48:23 pm
DSM
- PHX
1 stop5h 19m
Frontier
Deal found 4/7![Frontier logo]()
$169
This Frontier deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:50 am
PHX
- DSM
1 stop4h 19m
Frontier
Mon 5/48:23 pm
DSM
- PHX
1 stop5h 19m
Frontier
Deal found 4/3![Frontier logo]()
$180
This Frontier deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:50 am
PHX
- DSM
1 stop10h 24m
Frontier
Fri 5/12:04 pm
DSM
- PHX
1 stop8h 12m
Frontier
Deal found 4/6![Frontier logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/610:27 pm
PHX
- DSM
1 stop17h 34m
Multiple Airlines
Mon 5/112:16 pm
DSM
- PHX
1 stop27h 07m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$222
This Frontier deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/412:50 pm
PHX
- DSM
1 stop4h 48m
Frontier
Fri 5/82:16 pm
DSM
- PHX
1 stop11h 13m
Frontier
Deal found 4/6![Frontier logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:45 am
PHX
- DSM
1 stop10h 01m
Multiple Airlines
Mon 6/152:16 pm
DSM
- PHX
1 stop21h 46m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:40 am
PHX
- DSM
1 stop8h 21m
Multiple Airlines
Sun 5/1011:00 am
DSM
- PHX
1 stop23h 47m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/305:15 am
PHX
- DSM
1 stop12h 58m
Multiple Airlines
Mon 5/48:23 pm
DSM
- PHX
2 stops16h 42m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$264
This Frontier deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:15 am
PHX
- DSM
1 stop6h 16m
Frontier
Mon 6/12:16 pm
DSM
- PHX
1 stop8h 54m
Frontier
Deal found 4/5![Frontier logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:15 am
PHX
- DSM
1 stop6h 16m
Multiple Airlines
Mon 6/89:56 pm
DSM
- PHX
1 stop27h 29m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$270
Best flights from Mesa to Des MoinesDiscover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 7, 2026.
Discover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:51 pm
PHX
- DSM
2 stops17h 28m
Multiple Airlines
Sun 5/3110:26 pm
DSM
- PHX
1 stop26h 58m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$291
This United Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/92:51 pm
PHX
- DSM
1 stop6h 33m
United Airlines
Sat 5/166:15 am
DSM
- PHX
1 stop7h 05m
United Airlines
Deal found 4/3![United Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/91:25 pm
PHX
- DSM
1 stop5h 30m
Southwest
Sat 5/165:35 am
DSM
- PHX
2 stops8h 10m
Southwest
Deal found 4/3![Southwest logo]()
$354
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2811:05 pm
PHX
- DSM
1 stop8h 49m
Delta
Sat 5/22:44 pm
DSM
- PHX
1 stop8h 27m
Delta
Deal found 4/4![Delta logo]()
$365
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/52:35 pm
PHX
- DSM
1 stop4h 40m
Southwest
Wed 5/63:15 pm
DSM
- PHX
2 stops8h 25m
Southwest
Deal found 4/5![Southwest logo]()
$354
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/305:15 am
PHX
- DSM
1 stop12h 58m
Multiple Airlines
Thu 5/711:00 am
DSM
- PHX
1 stop14h 24m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$362
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/21:50 pm
PHX
- DSM
1 stop4h 26m
United Airlines
Sat 5/99:06 am
DSM
- PHX
1 stop7h 22m
United Airlines
Deal found 4/4![United Airlines logo]()
$365
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/301:55 pm
PHX
- DSM
Nonstop2h 40m
Southwest
Mon 5/41:45 pm
DSM
- PHX
Nonstop2h 55m
Southwest
Deal found 4/7![Southwest logo]()
$361
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/232:20 pm
PHX
- DSM
1 stop4h 35m
Southwest
Thu 5/287:10 pm
DSM
- PHX
1 stop5h 00m
Southwest
Deal found 4/5![Southwest logo]()
$365
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:20 pm
PHX
- DSM
1 stop4h 35m
Southwest
Tue 6/23:10 pm
DSM
- PHX
1 stop7h 30m
Southwest
Deal found 4/7![Southwest logo]()
$365
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:20 am
PHX
- DSM
1 stop4h 35m
Southwest
Sun 9/135:40 am
DSM
- PHX
1 stop7h 10m
Southwest
Deal found 4/6![Southwest logo]()
$384
Last-minute flights from Mesa to Des MoinesDiscover last-minute flight deals from Mesa to Des Moines. Data last updated April 7, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to Des Moines. Data last updated April 7, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:50 am
PHX
- DSM
1 stop10h 24m
Frontier
Fri 5/12:04 pm
DSM
- PHX
1 stop8h 12m
Frontier
Deal found 4/6![Frontier logo]()
$215
This Frontier deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:50 am
PHX
- DSM
1 stop8h 24m
Frontier
Fri 5/12:04 pm
DSM
- PHX
1 stop8h 12m
Frontier
Deal found 4/6![Frontier logo]()
$271
This Super.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:50 am
PHX
- DSM
1 stop4h 19m
Frontier
Mon 4/272:04 pm
DSM
- PHX
1 stop8h 12m
Frontier
Deal found 4/7![Frontier logo]()
$276
This Trip.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:24 pm
PHX
- DSM
1 stop13h 45m
Frontier
Mon 5/48:23 pm
DSM
- PHX
1 stop5h 19m
Frontier
Deal found 4/7![Frontier logo]()
$169
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/305:15 am
PHX
- DSM
1 stop12h 58m
Multiple Airlines
Mon 5/48:23 pm
DSM
- PHX
2 stops16h 42m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$264
This Frontier deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:50 am
PHX
- DSM
1 stop4h 19m
Frontier
Mon 5/48:23 pm
DSM
- PHX
1 stop5h 19m
Frontier
Deal found 4/3![Frontier logo]()
$180
This Frontier deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/412:50 pm
PHX
- DSM
1 stop4h 48m
Frontier
Fri 5/82:16 pm
DSM
- PHX
1 stop11h 13m
Frontier
Deal found 4/6![Frontier logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/610:27 pm
PHX
- DSM
1 stop17h 34m
Multiple Airlines
Mon 5/112:16 pm
DSM
- PHX
1 stop27h 07m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:40 am
PHX
- DSM
1 stop8h 21m
Multiple Airlines
Sun 5/1011:00 am
DSM
- PHX
1 stop23h 47m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$260
This Frontier deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:15 am
PHX
- DSM
1 stop6h 16m
Frontier
Mon 6/12:16 pm
DSM
- PHX
1 stop8h 54m
Frontier
Deal found 4/5![Frontier logo]()
$266
One-way flights from Mesa to Des MoinesSearch for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 7, 2026.
Search for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 7, 2026.
This Frontier deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:50 am
PHX
- DSM
1 stop4h 19m
Frontier
Deal found 4/3![Frontier logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/310:27 pm
PHX
- DSM
1 stop19h 44m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$103
This Super.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/24:29 pm
PHX
- DSM
1 stop19h 02m
Frontier
Deal found 4/3![Frontier logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:40 am
PHX
- DSM
1 stop27h 15m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:40 am
PHX
- DSM
1 stop10h 31m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/610:27 pm
PHX
- DSM
1 stop17h 34m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:40 am
PHX
- DSM
1 stop11h 04m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$111
This Trip.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/304:29 pm
PHX
- DSM
1 stop19h 02m
Frontier
Deal found 4/6![Frontier logo]()
$114
This Super.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:50 am
PHX
- DSM
1 stop4h 19m
Frontier
Deal found 4/6![Frontier logo]()
$119
Find flight deals from Mesa to Des Moines
Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated April 7, 2026.
Round-trip from | $169 (Trip.com) |
|---|---|
One-way from | $100 (Frontier) |
Popular in | July |
Cheapest in | November |
Average price | $389 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 7, 2026.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Wed 5/27
6:51 pm-2:19 pm
2 stops17h 28m
Des Moines
Sun 5/31
10:26 pm-11:24 pm
1 stop26h 58m
$291
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 5/9
2:51 pm-11:24 pm
1 stop6h 33m
Des Moines
Sat 5/16
6:15 am-11:20 am
1 stop7h 05m
$349
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 5/9
1:25 pm-8:55 pm
1 stop5h 30m
Des Moines
Sat 5/16
5:35 am-11:45 am
2 stops8h 10m
$354
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 5/5
2:35 pm-9:15 pm
1 stop4h 40m
Des Moines
Wed 5/6
3:15 pm-9:40 pm
2 stops8h 25m
$354
Quickest round-trip
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 4/30
1:55 pm-6:35 pm
Nonstop2h 40m
Des Moines
Mon 5/4
1:45 pm-2:40 pm
Nonstop2h 55m
$361
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 4/30
5:15 am-8:13 pm
1 stop12h 58m
Des Moines
Thu 5/7
11:00 am-11:24 pm
1 stop14h 24m
$362
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 4/28
11:05 pm-9:54 am
1 stop8h 49m
Des Moines
Sat 5/2
2:44 pm-9:11 pm
1 stop8h 27m
$365
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 5/2
1:50 pm-8:16 pm
1 stop4h 26m
Des Moines
Sat 5/9
9:06 am-2:28 pm
1 stop7h 22m
$365
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 5/23
2:20 pm-8:55 pm
1 stop4h 35m
Des Moines
Thu 5/28
7:10 pm-10:10 pm
1 stop5h 00m
$365
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 5/2
2:20 pm-8:55 pm
1 stop4h 35m
Des Moines
Tue 6/2
3:10 pm-8:40 pm
1 stop7h 30m
$365
Showing 1-10 of 22 resultsSorted by cheapest first
Best time to book a flight from Mesa to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
PHX-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Des Moines
MS9-DSM
PHX-DSM
How far ahead should I book a flight from Mesa to Des Moines?
Use this chart to determine the optimal time to book a round-trip flight from Mesa to Des Moines. Price data was last updated on April 3, 2026.
The price you pay for your flight from Mesa to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 64 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Mesa to Des Moines?
Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in April is currently the most expensive (average of $208). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MS9 to DSM?
Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 7, 2026.
It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 26% on the flight price compared to flying at noon, which is usually more expensive.
Weekly flight availability from Mesa to Des Moines
Explore weekly flight availability from Mesa to Des Moines. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated April 7, 2026.
The most flights from MS9 to DSM are scheduled on a Tuesday (4 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).
How much does it cost to fly round-trip from Mesa to Des Moines?
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 7, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAllegiant Air from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ames
Clive
Ankeny
Boone
West Des Moines
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Top 6 airlines flying from Mesa to Des Moines
Discover the top 6 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$67 | Average$175 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$137 | Average$208 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$164 | Average$288 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$222 | Average$371 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$222 | Average$387 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$275 | Average$376 | FlexibilityNo cancel fee | On-time69% |