HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$72+ Cheap flights from Mesa, AZ to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/11. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Mesa to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in April or February, booked 79 days in advance, depart on a Tuesday or Saturday and return on a Wednesday

Cheap flight deals from Mesa to Des Moines

Cheapest flights from Mesa to Des Moines
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Orbitz deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/207:00 amPHX - DSM
1 stop11h 44mFrontier
Sat 1/38:29 pmDSM - PHX
1 stop12h 52mFrontier
Deal found 12/17$268
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/202:00 pmPHX - DSM
1 stop7h 31mDelta
Tue 1/205:16 pmDSM - PHX
1 stop7h 30mDelta
Deal found 12/16$294
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/201:46 pmPHX - DSM
Nonstop2h 45mAmerican Airlines
Tue 1/202:34 pmDSM - PHX
Nonstop3h 10mAmerican Airlines
Deal found 12/16$295
This Expedia deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/199:31 amPHX - DSM
1 stop9h 13mFrontier
Sun 12/2110:17 amDSM - PHX
1 stop14h 34mFrontier
Deal found 12/16$352
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1611:55 pmPHX - DSM
1 stop8h 45mDelta
Tue 12/235:55 pmDSM - PHX
1 stop5h 52mDelta
Deal found 12/16$359
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1611:33 amPHX - DSM
2 stops8h 15mUnited Airlines
Tue 12/235:30 amDSM - PHX
1 stop5h 24mUnited Airlines
Deal found 12/16$364
This Southwest deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:40 pmPHX - DSM
1 stop5h 40mSouthwest
Sat 1/311:35 amDSM - PHX
Nonstop3h 10mSouthwest
Deal found 12/17$369
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/201:46 pmPHX - DSM
Nonstop2h 45mAmerican Airlines
Sat 1/36:20 pmDSM - PHX
Nonstop3h 03mAmerican Airlines
Deal found 12/17$375
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/208:34 pmPHX - DSM
Nonstop2h 55mAmerican Airlines
Mon 12/226:20 pmDSM - PHX
Nonstop3h 03mAmerican Airlines
Deal found 12/16$379
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/168:12 pmPHX - DSM
Nonstop2h 47mAmerican Airlines
Tue 12/235:07 amDSM - PHX
1 stop8h 12mAmerican Airlines
Deal found 12/16$385

Find flight deals from Mesa to Des Moines

Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated December 18, 2025.

Round-trip from

$176
(Kiwi.com)

One-way from

$72
(Kiwi.com)

Popular in

January

Cheapest in

April

Average price

$413
From Mesa to Des Moines
Search Deals
One-way flight from Mesa to Des Moines
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($80 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($26 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.

Fly from

Mesa

Fly to

Des Moines

Route

Depart

Return

Price

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 2/12

9:17 am-6:47 pm

1 stop8h 30m

Des Moines

Sun 2/15

7:30 am-1:53 pm

1 stop7h 23m

$198

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 1/8

6:10 am-10:09 pm

1 stop14h 59m

Des Moines

Sun 1/11

4:30 pm-8:58 am

2 stops17h 28m

$223

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Tue 1/13

11:55 am-10:29 pm

1 stop9h 34m

Des Moines

Tue 1/20

4:21 pm-9:02 pm

1 stop5h 41m

$239

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Tue 1/6

7:10 am-3:41 pm

1 stop7h 31m

Des Moines

Sat 1/17

1:03 pm-7:13 pm

1 stop7h 10m

$239

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 1/7

5:35 pm-3:40 pm

1 stop21h 05m

Des Moines

Fri 1/16

8:18 pm-12:59 am

1 stop5h 41m

$239

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Tue 1/13

4:15 pm-8:04 pm

Nonstop2h 49m

Des Moines

Tue 1/20

2:34 pm-4:44 pm

Nonstop3h 10m

$240

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 1/7

7:39 pm-3:40 pm

2 stops19h 01m

Des Moines

Mon 1/12

8:17 pm-12:56 pm

1 stop17h 39m

$248

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 1/7

12:45 pm-8:54 pm

1 stop7h 09m

Des Moines

Wed 1/14

5:16 pm-11:40 pm

1 stop7h 24m

$249

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 1/7

3:05 pm-9:24 pm

1 stop5h 19m

Des Moines

Tue 1/13

5:35 am-12:24 pm

1 stop7h 49m

$249

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Tue 1/6

1:55 pm-10:29 pm

1 stop7h 34m

Des Moines

Tue 1/13

11:26 am-7:13 pm

1 stop8h 47m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 21 results
1
2
3

Best time to book a flight from Mesa to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Des Moines

How far ahead should I book a flight from Mesa to Des Moines?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Des Moines. Price data was last updated on December 12, 2025.

The price you pay for your flight from Mesa to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 78 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Des Moines?

Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in March is currently the most expensive (average of $244). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to DSM?

Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 54% on the flight price compared to flying in the morning, which is usually more expensive.

What is the cheapest day to fly from Mesa to Des Moines?

Use this chart to determine the cheapest time to fly round-trip from Mesa to Des Moines. Price data was last updated on December 13, 2025.

Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Saturday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated December 18, 2025.
Read reviews from past customers who have flown Southwest, United Airlines, and American Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,249 reviews

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Overall

7.9

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
7.9
Good
4,249 reviews
Southwest
7.9
Good
4,249 reviews

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Overall

7.9

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,091 reviews
Southwest
7.9
Good
4,249 reviews

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Overall

7.9

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,054 reviews
Southwest
7.9
Good
4,249 reviews

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Overall

7.9

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Allegiant Air
7.2
Good
700 reviews
Southwest
7.9
Good
4,249 reviews

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Overall

7.9

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Frontier
5.8
Fair
3,082 reviews
Southwest
7.9
Good
4,249 reviews

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Overall

7.9

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mesa?

    For a flight from Mesa to Des Moines, you will be flying into Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 0 inbound flights from Mesa per day. 6 airlines have flights to Des Moines from Mesa on a regular basis.

  • How long is the flight from Mesa to Des Moines?

    Delta can get you from Mesa to Des Moines in just under 9h 34m. Your travel time can differ by up to . Mesa and Des Moines are separated by a distance of 1147 mi.

  • What are the cheapest airlines to fly from Mesa to Des Moines one-way?

    One-way options have recently been found by users for as low as $79 on Frontier. Other airlines that offer cheap prices include American Airlines from $89 and Delta from $118 one-way.

  • What are the most reliable airlines from Mesa to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mesa to Des Moines on time: SkyWest Airlines (88%), Alaska Airlines (78%), American Airlines (72%).

  • What are the cheapest flights from Mesa to Des Moines?

    While on average a flight from Mesa to Des Moines is generally $284, our data shows the cheapest flight currently is $88. When looking at the most popular route, (Phoenix Sky Harbor Intl - Des Moines), you can expect to pay $228 for that flight.

  • Can I find deals for flights from Mesa to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mesa to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Des Moines.

  • Can I find deals for business class flights from Mesa to Des Moines?

    Yes. Cheapflights offers flight deals from Mesa to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Des Moines?

    Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in March is currently the most expensive (average of $244). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mesa to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
Sky Harbor Intl to Omaha flights
Sky Harbor Intl to Cedar Rapids flights
Sky Harbor Intl to Des Moines flights
Las Vegas to Omaha flights
Sky Harbor Intl to Moline flights
Las Vegas to Cedar Rapids flights
Las Vegas to Des Moines flights
Tucson to Cedar Rapids flights
Tucson to Omaha flights
Sky Harbor Intl to Sioux City flights
Phoenix-Mesa Gateway to Des Moines flights
Tucson to Des Moines flights
Tucson to Moline flights
Las Vegas to Moline flights
Sky Harbor Intl to La Crosse flights
Tucson to Sioux City flights
Yuma to Omaha flights
Tucson to Waterloo flights
Sky Harbor Intl to Dubuque flights
Sky Harbor Intl to Burlington flights
Tucson to La Crosse flights
Sky Harbor Intl to Waterloo flights
Las Vegas to Burlington flights
Flagstaff to Omaha flights
Yuma to Des Moines flights
Flagstaff to Cedar Rapids flights

Top 6 airlines flying from Mesa to Des Moines

Discover the top 6 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$112Average$214FlexibilityNo cancel feeOn-time88%
FrontierCheapest$135Average$208FlexibilityNo cancel feeOn-time62%
DeltaCheapest$190Average$288FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$220Average$380FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$222Average$352FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$275Average$407FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.