What are the cheapest airlines to fly from Mesa to Des Moines one-way?

One-way options have recently been found by users for as low as $65 on Frontier. Other airlines that offer cheap prices include Delta from $108 and United Airlines from $124 one-way.

Weekly flight availability from Mesa to Des Moines

The most flights from MS9 to DSM are scheduled on a Monday (5 on average). You will have fewer flight options on Wednesday, which is when the least amount of flights are scheduled (1 on average).

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

What are the cheapest flights from Mesa to Des Moines?

While on average a flight from Mesa to Des Moines is generally $383, our data shows the cheapest flight currently is $194. When looking at the most popular route, (Phoenix Sky Harbor Intl - Des Moines), you can expect to pay $246 for that flight.

What are the most reliable airlines from Mesa to Des Moines?

Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mesa to Des Moines on time: Southwest (100%), SkyWest Airlines (87%), Envoy Air (86%).

What are the most popular airlines that fly from Mesa to Des Moines?

The most popular airlines flying from Mesa to Des Moines are American Airlines, Southwest and Frontier. Something to consider prior to booking your flight.

What airport do you fly into for flights to Des Moines from Mesa?

For a flight from Mesa to Des Moines, you will be flying into Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 3 inbound flights from Mesa per day. 5 airlines have flights to Des Moines from Mesa on a regular basis.

Can I find deals for flights from Mesa to Des Moines that include hotel bookings?

Yes. In addition to deals on Mesa to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Mesa to Des Moines?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Des Moines.

Can I find deals for business class flights from Mesa to Des Moines?

Yes. Cheapflights offers flight deals from Mesa to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

Find Cheap Flights from Mesa to Des Moines

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Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in November or January, booked 65 days in advance, depart on a Wednesday or Saturday and return on a Saturday

Find flight deals from Mesa to Des Moines

Popular in	August
Cheapest in	November
Average price	$429

Highest demand for flights based on searches. 11% potential increase in price ($53 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).

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Average for round-trip flights in October 2026

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Everything you need to know about your flight from Mesa to Des Moines

Prices

Airlines

What is the cheapest time of day to fly from MS9 to DSM?

It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 32% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Mesa to Des Moines?

Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Saturday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Des Moines

Read reviews from past customers who have flown Southwest,United Airlines, andAllegiant Air from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

7.9

Good

4,215 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Southwest

7.9

Good

4,215 reviews

Southwest

7.9

Good

4,215 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

United Airlines

7.4

Good

10,357 reviews

Southwest

7.9

Good

4,215 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Allegiant Air

7.3

Good

678 reviews

Southwest

7.9

Good

4,215 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

American Airlines

7.0

Good

12,162 reviews

Southwest

7.9

Good

4,215 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Frontier

5.5

Fair

2,540 reviews

Southwest

7.9

Good

4,215 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Related info for your journey

What airport do you fly into for flights to Des Moines from Mesa?
For a flight from Mesa to Des Moines, you will be flying into Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 3 inbound flights from Mesa per day. 5 airlines have flights to Des Moines from Mesa on a regular basis.
What are the cheapest airlines to fly from Mesa to Des Moines one-way?
One-way options have recently been found by users for as low as $65 on Frontier. Other airlines that offer cheap prices include Delta from $108 and United Airlines from $124 one-way.
What are the most reliable airlines from Mesa to Des Moines?
Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mesa to Des Moines on time: Southwest (100%), SkyWest Airlines (87%), Envoy Air (86%).
What are the cheapest flights from Mesa to Des Moines?
While on average a flight from Mesa to Des Moines is generally $383, our data shows the cheapest flight currently is $194. When looking at the most popular route, (Phoenix Sky Harbor Intl - Des Moines), you can expect to pay $246 for that flight.
Can I find deals for flights from Mesa to Des Moines that include hotel bookings?
Yes. In addition to deals on Mesa to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Mesa to Des Moines?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Des Moines.
Can I find deals for business class flights from Mesa to Des Moines?
Yes. Cheapflights offers flight deals from Mesa to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Altoona

Clive

West Des Moines

Ames

Johnston

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Norwalk

Ankeny

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Top 5 airlines flying from Mesa to Des Moines

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$90	Average$243	FlexibilityNo cancel fee	On-time62%
Allegiant Air	Cheapest$139	Average$250	FlexibilityNo cancel fee	On-time88%
Southwest	Cheapest$263	Average$452	FlexibilityNo cancel fee	On-time63%
American Airlines	Cheapest$272	Average$429	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$290	Average$396	FlexibilityNo cancel fee	On-time69%

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Cheap flights from Mesa, AZ to Des Moines (DSM)

Find cheap flights from Mesa to Des Moines with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from Mesa to Des Moines

Popular in

Cheapest in

Average price

Cheapflights Insights

What is the cheapest time of day to fly from MS9 to DSM?

It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 32% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Mesa to Des Moines?

Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Saturday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Mesa to Des Moines

The most flights from MS9 to DSM are scheduled on a Monday (5 on average). You will have fewer flight options on Wednesday, which is when the least amount of flights are scheduled (1 on average).

Reviews of airlines servicing Des Moines

Read reviews from past customers who have flown Southwest,United Airlines, andAllegiant Air from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

What airport do you fly into for flights to Des Moines from Mesa?

What are the cheapest airlines to fly from Mesa to Des Moines one-way?

What are the most reliable airlines from Mesa to Des Moines?

What are the cheapest flights from Mesa to Des Moines?

Can I find deals for flights from Mesa to Des Moines that include hotel bookings?

How can I find direct flights from Mesa to Des Moines?

Can I find deals for business class flights from Mesa to Des Moines?

Traveling to a place near Des Moines?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Mesa to Des Moines

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Complete your trip

Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.

Other flights to Des Moines

Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 14, 2026.

Search flights from Mesa to Des Moines by cabin class

Find flights from Mesa to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Mesa and Des Moines flights

Browse other Mesa and Des Moines flight options. Last updated on October 14, 2026.

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