$67+ Cheap flights from Mesa, AZ to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from Mesa to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in April or February, booked 79 days in advance, depart on a Tuesday or Saturday and return on a Wednesday
Cheap flight deals from Mesa to Des Moines
Cheapest flights from Mesa to Des MoinesExplore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.
This Kiwi.com deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Priceline deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Frontier deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Frontier deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Southwest deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Find flight deals from Mesa to Des Moines
Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated December 4, 2025.
Round-trip from | $132 (Kiwi.com) |
|---|---|
One-way from | $67 (Trip.com) |
Popular in | January |
Cheapest in | April |
Average price | $379 |
Cheapflights Fare Finder
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 1/8
6:10 am-10:09 pm
1 stop14h 59m
Des Moines
Sun 1/11
4:30 pm-8:58 am
2 stops17h 28m
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Fri 2/20
8:02 pm-11:59 pm
Nonstop2h 57m
Des Moines
Thu 2/26
2:24 pm-4:39 pm
Nonstop3h 15m
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Wed 2/4
1:10 pm-9:10 pm
2 stops7h 00m
Des Moines
Fri 2/6
4:40 pm-11:15 pm
1 stop7h 35m
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 2/21
4:40 pm-10:25 pm
1 stop4h 45m
Des Moines
Wed 2/25
8:35 am-3:40 pm
2 stops8h 05m
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 3/3
10:30 am-7:20 pm
2 stops7h 50m
Des Moines
Sat 3/7
7:55 pm-10:00 pm
Nonstop3h 05m
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sun 1/18
1:20 pm-9:10 pm
1 stop6h 50m
Des Moines
Wed 1/21
12:05 pm-5:40 pm
1 stop6h 35m
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 1/8
8:11 pm-11:58 pm
Nonstop2h 47m
Des Moines
Sun 1/11
7:40 am-5:20 pm
1 stop10h 40m
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 2/28
2:00 pm-5:35 pm
Nonstop2h 35m
Des Moines
Sat 3/7
6:45 am-10:35 am
1 stop4h 50m
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 1/8
8:25 am-2:40 pm
1 stop5h 15m
Des Moines
Sun 1/11
11:30 am-1:40 pm
Nonstop3h 10m
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 2/3
8:25 am-2:40 pm
1 stop5h 15m
Best time to book a flight from Mesa to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Des Moines
How far ahead should I book a flight from Mesa to Des Moines?
Use this chart to determine the optimal time to book a round-trip flight from Mesa to Des Moines. Price data was last updated on November 28, 2025.
The price you pay for your flight from Mesa to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 78 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Mesa to Des Moines?
Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in March is currently the most expensive (average of $244). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MS9 to DSM?
Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 4, 2025.
It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 54% on the flight price compared to flying in the morning, which is usually more expensive.
What is the cheapest day to fly from Mesa to Des Moines?
Use this chart to determine the cheapest time to fly round-trip from Mesa to Des Moines. Price data was last updated on November 29, 2025.
Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Saturday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
Weekly flight availability from Mesa to Des Moines
Explore weekly flight availability from Mesa to Des Moines. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated December 4, 2025.
The most flights from MS9 to DSM are scheduled on a Thursday (6 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (4 on average).
How much does it cost to fly round-trip from Mesa to Des Moines?
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated December 4, 2025.
Read reviews from past customers who have flown Southwest, United Airlines, and American Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
Overall
Crew
Boarding
Food
Entertainment
Reviews
Thomas,Dec 2025
SEA - DEN
Comfort
Overall
Crew
Boarding
Food
Entertainment
Reviews
Thomas,Dec 2025
SEA - DEN
Comfort
Overall
Crew
Boarding
Food
Entertainment
Reviews
Thomas,Dec 2025
SEA - DEN
Comfort
Overall
Crew
Boarding
Food
Entertainment
Reviews
Thomas,Dec 2025
SEA - DEN
Comfort
Overall
Crew
Boarding
Food
Entertainment
Reviews
Thomas,Dec 2025
SEA - DEN
Comfort
Overall
Crew
Boarding
Food
Entertainment
Reviews
Thomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
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Alternative routes for Mesa to Des Moines
See prices for flight routes from nearby airports that may be better suited for you.
Top 6 airlines flying from Mesa to Des Moines
Discover the top 6 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$112 | Average$213 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$135 | Average$208 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$190 | Average$307 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$221 | Average$380 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$222 | Average$353 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$275 | Average$407 | FlexibilityNo cancel fee | On-time69% |