HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$84+ Cheap flights from Mesa, AZ to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
dic. 26 — ene. 21
vie. 12/26
vie. 1/2
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Mesa to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in April or February, booked 79 days in advance, depart on a Tuesday or Saturday and return on a Wednesday

Find flight deals from Mesa to Des Moines

Cheapest flights from Mesa to Des Moines
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on noviembre 26, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/1512:16 pmPHX - DSM
1 stop5h 47mFrontier
jue. 2/127:36 pmDSM - PHX
1 stop5h 57mFrontier
Deal found 11/24$169
This Kiwi.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/1512:16 pmPHX - DSM
1 stop5h 47mMultiple Airlines
lun. 2/98:30 amDSM - PHX
1 stop12h 37mMultiple Airlines
Deal found 11/24$172
This Kiwi.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/1110:26 pmPHX - DSM
1 stop19h 37mFrontier
lun. 12/157:58 pmDSM - PHX
1 stop20h 09mFrontier
Deal found 11/24$188
This Kiwi.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/1512:16 pmPHX - DSM
1 stop5h 47mMultiple Airlines
dom. 2/88:30 amDSM - PHX
1 stop13h 15mMultiple Airlines
Deal found 11/24$190
This Priceline deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/89:16 amPHX - DSM
1 stop8h 47mFrontier
lun. 12/157:58 pmDSM - PHX
1 stop5h 46mFrontier
Deal found 11/25$203
This Frontier deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/512:15 pmPHX - DSM
1 stop5h 48mFrontier
lun. 12/157:58 pmDSM - PHX
1 stop5h 46mFrontier
Deal found 11/26$207
This Kiwi.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/2510:31 pmPHX - DSM
1 stop20h 13mFrontier
jue. 2/127:36 pmDSM - PHX
1 stop5h 57mFrontier
Deal found 11/24$211
This Southwest deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/171:25 pmPHX - DSM
1 stop5h 30mSouthwest
mié. 2/118:35 amDSM - PHX
1 stop7h 05mSouthwest
Deal found 11/24$213
This Kiwi.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/2510:31 pmPHX - DSM
1 stop20h 13mMultiple Airlines
lun. 2/98:30 amDSM - PHX
1 stop12h 37mMultiple Airlines
Deal found 11/24$214

Cheap flight deals from Mesa to Des Moines

Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated noviembre 26, 2025.

Round-trip from

$169
(Kiwi.com)

One-way from

$84
(Kiwi.com)

Popular in

January

Cheapest in

April

Average price

$327
From Mesa to Des Moines
Search Deals
One-way flight from Mesa to Des Moines
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($71 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($26 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 26, 2025.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.

Fly from

Mesa

Fly to

Des Moines

Route

Depart

Return

Price

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

mié. 1/7

1:20 pm-9:10 pm

1 stop6h 50m

Des Moines

mar. 1/13

8:35 am-3:35 pm

1 stop8h 00m

$269

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

dom. 12/14

12:59 am-10:21 am

1 stop8h 22m

Des Moines

lun. 2/9

10:21 am-7:45 pm

1 stop10h 24m

$319

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

sáb. 12/13

4:45 pm-8:25 pm

Nonstop2h 40m

Des Moines

mar. 12/16

6:15 am-11:20 am

1 stop6h 05m

$326

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

vie. 12/12

12:59 am-10:21 am

1 stop8h 22m

Des Moines

mar. 12/16

11:01 am-5:49 pm

1 stop7h 48m

$336

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

jue. 2/12

12:59 am-10:17 am

1 stop8h 18m

Des Moines

lun. 2/16

4:21 pm-9:17 pm

1 stop5h 56m

$341

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

lun. 12/8

12:59 am-10:21 am

1 stop8h 22m

Des Moines

sáb. 12/13

6:50 am-2:00 pm

1 stop8h 10m

$343

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

sáb. 3/7

11:30 am-9:45 pm

2 stops9h 15m

Des Moines

lun. 3/9

6:50 am-12:50 pm

2 stops8h 00m

$351

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

vie. 12/12

11:40 am-3:30 pm

Nonstop2h 50m

Des Moines

dom. 12/14

4:10 pm-6:15 pm

Nonstop3h 05m

$363

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

jue. 4/9

11:59 pm-10:22 am

1 stop8h 23m

Des Moines

dom. 4/12

4:25 pm-8:20 pm

1 stop5h 55m

$380

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

lun. 12/22

8:40 am-12:25 pm

Nonstop2h 45m

Des Moines

mar. 12/30

6:50 pm-1:10 am

1 stop7h 20m

$380

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/24

Showing 1-10 of 18 results
1
2

Best time to book a flight from Mesa to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Des Moines

How far ahead should I book a flight from Mesa to Des Moines?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Des Moines. Price data was last updated on November 21, 2025.

The price you pay for your flight from Mesa to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 78 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Des Moines?

Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in March is currently the most expensive (average of $244). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to DSM?

Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated noviembre 26, 2025.

It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 54% on the flight price compared to flying in the morning, which is usually more expensive.

What is the cheapest day to fly from Mesa to Des Moines?

Use this chart to determine the cheapest time to fly round-trip from Mesa to Des Moines. Price data was last updated on November 25, 2025.

Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Saturday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated noviembre 26, 2025.
Read reviews from past customers who have flown Southwest, United Airlines, and American Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,253 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,253 reviews
Southwest
8.0
Very good
4,253 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
9,047 reviews
Southwest
8.0
Very good
4,253 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,038 reviews
Southwest
8.0
Very good
4,253 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Allegiant Air
7.2
Good
700 reviews
Southwest
8.0
Very good
4,253 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Frontier
5.8
Fair
3,100 reviews
Southwest
8.0
Very good
4,253 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mesa?

    For a flight from Mesa to Des Moines, you will be flying into Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 3 inbound flights from Mesa per day. 6 airlines have flights to Des Moines from Mesa on a regular basis.

  • How long is the flight from Mesa to Des Moines?

    Southwest and Delta can get you from Mesa to Des Moines in just under 6h 50m. Your travel time can differ by up to 1h 32m. Mesa and Des Moines are separated by a distance of 1147 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most reliable airlines from Mesa to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mesa to Des Moines on time: Alaska Airlines (83%), SkyWest Airlines (82%), American Airlines (77%).

  • What are the cheapest flights from Mesa to Des Moines?

    While on average a flight from Mesa to Des Moines is generally $245, our data shows the cheapest flight currently is $88. When looking at the most popular route, (Phoenix Sky Harbor Intl - Des Moines), you can expect to pay $201 for that flight.

  • Can I find deals for flights from Mesa to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mesa to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Des Moines.

  • Can I find deals for business class flights from Mesa to Des Moines?

    Yes. Cheapflights offers flight deals from Mesa to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Des Moines?

    Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in March is currently the most expensive (average of $244). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mesa to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
Sky Harbor Intl to Omaha flights
Sky Harbor Intl to Des Moines flights
Tucson to Des Moines flights
Sky Harbor Intl to Cedar Rapids flights
Tucson to Cedar Rapids flights
Las Vegas to Omaha flights
Sky Harbor Intl to Moline flights
Tucson to Omaha flights
Las Vegas to Des Moines flights
Phoenix-Mesa Gateway to Des Moines flights
Las Vegas to Moline flights
Las Vegas to Cedar Rapids flights
Tucson to Moline flights
Sky Harbor Intl to Sioux City flights
Tucson to Sioux City flights
Sky Harbor Intl to La Crosse flights
Sky Harbor Intl to Waterloo flights
Sky Harbor Intl to Dubuque flights
Tucson to Waterloo flights
Flagstaff to Omaha flights
Yuma to Omaha flights
Tucson to La Crosse flights
Las Vegas to Burlington flights
Sky Harbor Intl to Burlington flights
Yuma to Des Moines flights
Flagstaff to Cedar Rapids flights

Top 6 airlines flying from Mesa to Des Moines

Discover the top 6 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$112Average$214FlexibilityNo cancel feeOn-time88%
FrontierCheapest$156Average$210FlexibilityNo cancel feeOn-time62%
DeltaCheapest$190Average$307FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$220Average$380FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$222Average$347FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$275Average$408FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.