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Des Moines

$71+ Cheap flights from Mesa, AZ to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Jan 27 — Feb 31
Tue 1/27
Tue 2/3
1 adult, Economy
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Find cheap flights from Mesa to Des Moines with Cheapflights

1. Tell us where you want to go

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Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in April or February, booked 79 days in advance, depart on a Tuesday or Saturday and return on a Wednesday

Cheap flight deals from Mesa to Des Moines

Cheapest flights from Mesa to Des Moines
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

This Southwest deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/308:40 amPHX - DSM
Nonstop2h 45mSouthwest
Sat 1/311:35 amDSM - PHX
Nonstop3h 10mSouthwest
Deal found 12/27$309
This Southwest deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/288:40 amPHX - DSM
Nonstop2h 45mSouthwest
Sat 1/311:35 amDSM - PHX
Nonstop3h 10mSouthwest
Deal found 12/27$371
This Delta deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2612:45 pmPHX - DSM
1 stop6h 59mDelta
Tue 12/3010:29 amDSM - PHX
1 stop9h 41mDelta
Deal found 12/26$399
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/279:59 amPHX - DSM
Nonstop2h 58mAmerican Airlines
Sun 12/283:38 pmDSM - PHX
1 stop6h 39mAmerican Airlines
Deal found 12/26$411
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/269:59 amPHX - DSM
Nonstop2h 58mAmerican Airlines
Tue 12/302:40 pmDSM - PHX
Nonstop3h 02mAmerican Airlines
Deal found 12/26$452

Find flight deals from Mesa to Des Moines

Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated December 28, 2025.

Round-trip from

$143
(Kiwi.com)

One-way from

$71
(Trip.com)

Popular in

December

Cheapest in

April

Average price

$425
From Mesa to Des Moines
Search Deals
One-way flight from Mesa to Des Moines
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($14 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.

Fly from

Mesa

Fly to

Des Moines

Route

Depart

Return

Price

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Mon 2/23

6:00 am-6:32 pm

1 stop11h 32m

Des Moines

Fri 2/27

7:59 pm-8:12 am

1 stop13h 13m

$179

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 1/28

9:59 am-1:48 pm

Nonstop2h 49m

Des Moines

Sat 1/31

5:25 am-7:49 am

Nonstop3h 24m

$209

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Fri 1/9

9:16 am-7:22 pm

1 stop9h 06m

Des Moines

Mon 1/12

8:17 pm-12:29 am

1 stop5h 12m

$217

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 1/15

10:16 pm-3:40 pm

1 stop16h 24m

Des Moines

Mon 1/19

8:18 pm-5:32 pm

2 stops22h 14m

$220

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 2/18

11:59 pm-9:56 am

1 stop8h 57m

Des Moines

Tue 2/24

4:20 pm-9:17 pm

1 stop5h 57m

$229

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Sat 2/7

3:55 pm-10:09 pm

2 stops29h 14m

Des Moines

Fri 2/20

7:17 pm-12:41 am

1 stop6h 24m

$246

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 2/25

9:53 am-1:43 pm

Nonstop2h 50m

Des Moines

Sat 2/28

2:24 pm-4:39 pm

Nonstop3h 15m

$251

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 2/18

11:35 am-9:10 pm

2 stops8h 35m

Des Moines

Tue 2/24

8:35 am-3:35 pm

1 stop8h 00m

$255

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 2/11

4:15 pm-8:04 pm

Nonstop2h 49m

Des Moines

Sun 2/15

5:10 am-7:25 am

Nonstop3h 15m

$265

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Fri 2/20

1:50 pm-5:36 pm

Nonstop2h 46m

Des Moines

Mon 2/23

6:20 pm-8:34 pm

Nonstop3h 14m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/27

Showing 1-10 of 23 results
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Best time to book a flight from Mesa to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Des Moines

How far ahead should I book a flight from Mesa to Des Moines?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Des Moines. Price data was last updated on December 26, 2025.

The price you pay for your flight from Mesa to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 78 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Des Moines?

Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in March is currently the most expensive (average of $244). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to DSM?

Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 28, 2025.

It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 29% on the flight price compared to flying in the morning, which is usually more expensive.

Weekly flight availability from Mesa to Des Moines

Explore weekly flight availability from Mesa to Des Moines. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated December 28, 2025.

The most flights from MS9 to DSM are scheduled on a Monday (7 on average). You will have fewer flight options on Wednesday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated December 28, 2025.
Read reviews from past customers who have flown Southwest, United Airlines, and American Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,256 reviews

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,256 reviews
Southwest
8.0
Very good
4,256 reviews

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,113 reviews
Southwest
8.0
Very good
4,256 reviews

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,072 reviews
Southwest
8.0
Very good
4,256 reviews

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Allegiant Air
7.2
Good
703 reviews
Southwest
8.0
Very good
4,256 reviews

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Frontier
5.8
Fair
3,065 reviews
Southwest
8.0
Very good
4,256 reviews

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mesa?

    For a flight from Mesa to Des Moines, you will be flying into Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 6 inbound flights from Mesa per day. 6 airlines have flights to Des Moines from Mesa on a regular basis.

  • How long is the flight from Mesa to Des Moines?

    Frontier, American Airlines, and Delta can get you from Mesa to Des Moines in just under 2h 49m. Your travel time can differ by up to 8h 43m. Mesa and Des Moines are separated by a distance of 1147 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Mesa to Des Moines one-way?

    One-way options have recently been found by users for as low as $79 on Frontier. Other airlines that offer cheap prices include American Airlines from $89 and Delta from $118 one-way.

  • What are the most reliable airlines from Mesa to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mesa to Des Moines on time: SkyWest Airlines (88%), Alaska Airlines (78%), American Airlines (72%).

  • What are the cheapest flights from Mesa to Des Moines?

    While on average a flight from Mesa to Des Moines is generally $290, our data shows the cheapest flight currently is $153. When looking at the most popular route, (Phoenix Sky Harbor Intl - Des Moines), you can expect to pay $208 for that flight.

  • Can I find deals for flights from Mesa to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mesa to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Des Moines.

  • Can I find deals for business class flights from Mesa to Des Moines?

    Yes. Cheapflights offers flight deals from Mesa to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Des Moines?

    Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in March is currently the most expensive (average of $244). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Top 6 airlines flying from Mesa to Des Moines

Discover the top 6 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$112Average$215FlexibilityNo cancel feeOn-time88%
FrontierCheapest$135Average$208FlexibilityNo cancel feeOn-time62%
DeltaCheapest$190Average$288FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$222Average$352FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$224Average$380FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$275Average$407FlexibilityNo cancel feeOn-time69%

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