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Des Moines

$49+ Cheap flights from Mesa, AZ to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/14. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Mar 29 — Apr 51
Sun 3/29
Sun 4/5
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in April or November, booked 79 days in advance, depart on a Tuesday or Saturday and return on a Wednesday

Cheap flight deals from Mesa to Des Moines

Cheapest flights from Mesa to Des Moines
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 27, 2026.

This Super.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1311:17 am
PHX
-
DSM
Nonstop2h 41m
Frontier
Sat 3/212:56 pm
DSM
-
PHX
Nonstop3h 20m
Frontier
Deal found 2/23$107
This Super.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1311:17 am
PHX
-
DSM
Nonstop2h 41m
Frontier
Fri 3/204:43 pm
DSM
-
PHX
Nonstop3h 20m
Frontier
Deal found 2/22$117
This Super.com deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:30 am
PHX
-
DSM
Nonstop2h 41m
Frontier
Sat 3/212:56 pm
DSM
-
PHX
Nonstop3h 20m
Frontier
Deal found 2/25$128
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/99:24 pm
PHX
-
DSM
1 stop19h 50m
Frontier
Mon 4/138:14 pm
DSM
-
PHX
1 stop23h 33m
Frontier
Deal found 2/23$169
This Frontier deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:30 am
PHX
-
DSM
Nonstop2h 41m
Frontier
Wed 3/185:41 pm
DSM
-
PHX
Nonstop3h 20m
Frontier
Deal found 2/26$177
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/88:54 am
PHX
-
DSM
Nonstop2h 53m
American Airlines
Tue 4/142:38 pm
DSM
-
PHX
Nonstop3h 09m
American Airlines
Deal found 2/23$199
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/912:40 pm
PHX
-
DSM
Nonstop2h 49m
American Airlines
Mon 4/132:38 pm
DSM
-
PHX
Nonstop3h 09m
American Airlines
Deal found 2/23$200
This Kiwi.com deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:24 pm
PHX
-
DSM
1 stop19h 50m
Multiple Airlines
Mon 4/69:45 pm
DSM
-
PHX
1 stop24h 31m
Multiple Airlines
Deal found 2/26$208
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:50 am
PHX
-
DSM
1 stop10h 24m
Multiple Airlines
Sun 4/57:30 am
DSM
-
PHX
1 stop28h 43m
Multiple Airlines
Deal found 2/23$211

Find flight deals from Mesa to Des Moines

Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated February 27, 2026.

Round-trip from

$107
(Super.com)

One-way from

$49
(Super.com)

Popular in

July

Cheapest in

April

Average price

$397
From Mesa to Des Moines
Search Deals
One-way flight from Mesa to Des Moines
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($14 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 27, 2026.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 4/9

6:00 am-4:15 pm

2 stops8h 15m

Des Moines

Mon 4/13

5:17 pm-8:19 pm

1 stop5h 02m

$224

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Tue 3/24

11:59 pm-10:09 am

1 stop8h 10m

Des Moines

Tue 3/31

4:25 pm-9:52 pm

1 stop7h 27m

$239

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 5/6

6:10 am-2:05 pm

1 stop5h 55m

Des Moines

Mon 5/11

1:45 pm-2:40 pm

Nonstop2h 55m

$272

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 4/2

11:55 pm-10:48 am

1 stop8h 53m

Des Moines

Sat 4/4

4:25 pm-9:52 pm

1 stop7h 27m

$314

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Tue 3/3

2:10 pm-7:20 pm

1 stop4h 10m

Des Moines

Sat 3/7

7:55 pm-10:00 pm

Nonstop3h 05m

$334

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Mon 3/30

11:55 pm-11:40 am

1 stop9h 45m

Des Moines

Fri 4/3

2:15 pm-3:20 pm

Nonstop3h 05m

$355

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 4/23

11:05 pm-9:54 am

1 stop8h 49m

Des Moines

Sun 4/26

6:10 am-2:04 pm

1 stop9h 54m

$359

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Sat 5/16

1:50 pm-12:24 am

2 stops8h 34m

Des Moines

Tue 5/19

11:31 am-9:32 pm

2 stops12h 01m

$375

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Wed 4/15

12:37 pm-10:43 pm

1 stop8h 06m

$110

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Tue 4/21

11:05 pm-9:54 am

1 stop8h 49m

$110

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/24

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Best time to book a flight from Mesa to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Des Moines

How far ahead should I book a flight from Mesa to Des Moines?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Des Moines. Price data was last updated on February 20, 2026.

The price you pay for your flight from Mesa to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 78 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Des Moines?

Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in April is currently the most expensive (average of $176). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to DSM?

Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 27, 2026.

It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 31% on the flight price compared to flying in the morning, which is usually more expensive.

Weekly flight availability from Mesa to Des Moines

Explore weekly flight availability from Mesa to Des Moines. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated February 27, 2026.

The most flights from MS9 to DSM are scheduled on a Thursday (7 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (4 on average).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated February 27, 2026.
Read reviews from past customers who have flown Southwest, United Airlines, and American Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,301 reviews

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
6.0
Good

Scott,Feb 2026

HOU - FLL

Delayed by 45 minutes leaving Houston, making a 3.5 hour layover that much longer.
Southwest
8.0
Very good
4,301 reviews
Southwest
8.0
Very good
4,301 reviews

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
6.0
Good

Scott,Feb 2026

HOU - FLL

Delayed by 45 minutes leaving Houston, making a 3.5 hour layover that much longer.
United Airlines
7.4
Good
9,352 reviews
Southwest
8.0
Very good
4,301 reviews

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
6.0
Good

Scott,Feb 2026

HOU - FLL

Delayed by 45 minutes leaving Houston, making a 3.5 hour layover that much longer.
American Airlines
7.2
Good
11,359 reviews
Southwest
8.0
Very good
4,301 reviews

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
6.0
Good

Scott,Feb 2026

HOU - FLL

Delayed by 45 minutes leaving Houston, making a 3.5 hour layover that much longer.
Allegiant Air
7.2
Good
715 reviews
Southwest
8.0
Very good
4,301 reviews

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
6.0
Good

Scott,Feb 2026

HOU - FLL

Delayed by 45 minutes leaving Houston, making a 3.5 hour layover that much longer.
Frontier
5.7
Fair
3,041 reviews
Southwest
8.0
Very good
4,301 reviews

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
6.0
Good

Scott,Feb 2026

HOU - FLL

Delayed by 45 minutes leaving Houston, making a 3.5 hour layover that much longer.

Related info for your journey

Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mesa?

    For a flight from Mesa to Des Moines, you will be flying into Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 5 inbound flights from Mesa per day. 6 airlines have flights to Des Moines from Mesa on a regular basis.

  • How long is the flight from Mesa to Des Moines?

    United Airlines, Delta, and Southwest can get you from Mesa to Des Moines in just under 5h 55m. Your travel time can differ by up to 2h 20m. Mesa and Des Moines are separated by a distance of 1147 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Mesa to Des Moines one-way?

    One-way options have recently been found by users for as low as $61 on Allegiant Air. Other airlines that offer cheap prices include Frontier from $84 and American Airlines from $89 one-way.

  • What are the most reliable airlines from Mesa to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mesa to Des Moines on time: SkyWest Airlines (80%), American Airlines (72%), Alaska Airlines (67%).

  • What are the cheapest flights from Mesa to Des Moines?

    While on average a flight from Mesa to Des Moines is generally $319, our data shows the cheapest flight currently is $76. When looking at the most popular route, (Phoenix Sky Harbor Intl - Des Moines), you can expect to pay $213 for that flight.

  • Can I find deals for flights from Mesa to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mesa to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Des Moines.

  • Can I find deals for business class flights from Mesa to Des Moines?

    Yes. Cheapflights offers flight deals from Mesa to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Des Moines?

    Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in April is currently the most expensive (average of $176). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ankeny
Boone
Ames
Clive
West Des Moines

Browse thousands of different options on Cheapflights for your next trip

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Top 6 airlines flying from Mesa to Des Moines

Discover the top 6 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$67Average$194FlexibilityNo cancel feeOn-time88%
FrontierCheapest$137Average$208FlexibilityNo cancel feeOn-time62%
DeltaCheapest$164Average$307FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$220Average$380FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$222Average$358FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$275Average$376FlexibilityNo cancel feeOn-time69%

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