$77+ Cheap flights from Mesa, AZ to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/9. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Aug 18 — Aug 251
Round-trip
1 adult, Economy
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Find cheap flights from Mesa to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in November or October, booked 65 days in advance, depart on a Wednesday or Monday and return on a Wednesday
Cheap flight deals from Mesa to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mesa to Des MoinesExplore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 19, 2026.
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:09 pm
PHX
- DSM
1 stop20h 51m
Multiple Airlines
Mon 8/248:38 pm
DSM
- PHX
1 stop18h 21m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$188
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Mon 8/1010:06 pm
DSM
- PHX
1 stop16h 53m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Fri 8/79:21 pm
DSM
- PHX
1 stop16h 06m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1510:40 pm
PHX
- DSM
1 stop10h 17m
Multiple Airlines
Mon 10/191:47 pm
DSM
- PHX
1 stop22h 26m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/69:58 pm
PHX
- DSM
1 stop20h 33m
Multiple Airlines
Mon 8/1010:06 pm
DSM
- PHX
1 stop16h 53m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1310:40 pm
PHX
- DSM
1 stop13h 12m
Multiple Airlines
Mon 10/191:47 pm
DSM
- PHX
1 stop22h 26m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:45 am
PHX
- DSM
1 stop11h 09m
Multiple Airlines
Fri 8/1410:06 pm
DSM
- PHX
1 stop15h 21m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/247:05 am
PHX
- DSM
1 stop12h 01m
Multiple Airlines
Sun 9/279:56 pm
DSM
- PHX
1 stop25h 39m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/289:03 am
PHX
- DSM
1 stop7h 45m
Multiple Airlines
Sun 8/309:50 pm
DSM
- PHX
1 stop27h 34m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:45 am
PHX
- DSM
1 stop11h 09m
Multiple Airlines
Fri 8/79:21 pm
DSM
- PHX
1 stop16h 06m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Sun 8/99:44 pm
DSM
- PHX
1 stop15h 43m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$232
Best flights from Mesa to Des MoinesDiscover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 19, 2026.
Discover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 19, 2026.
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/710:00 am
PHX
- DSM
1 stop6h 23m
United Airlines
Sat 11/141:35 pm
DSM
- PHX
1 stop5h 34m
United Airlines
Deal found 7/15![United Airlines logo]()
$336
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1512:25 pm
PHX
- DSM
1 stop6h 20m
Southwest
Wed 8/196:10 am
DSM
- PHX
2 stops8h 20m
Southwest
Deal found 7/15![Southwest logo]()
$346
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/239:45 am
PHX
- DSM
1 stop6h 00m
Southwest
Tue 9/296:10 am
DSM
- PHX
1 stop6h 50m
Southwest
Deal found 7/17![Southwest logo]()
$387
This United Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/82:45 pm
PHX
- DSM
1 stop6h 15m
United Airlines
Sat 8/151:35 pm
DSM
- PHX
1 stop5h 35m
United Airlines
Deal found 7/18![United Airlines logo]()
$387
This Southwest deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/812:25 pm
PHX
- DSM
1 stop6h 20m
Southwest
Sat 8/157:20 am
DSM
- PHX
2 stops7h 15m
Southwest
Deal found 7/18![Southwest logo]()
$392
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:05 am
PHX
- DSM
1 stop5h 35m
Southwest
Sun 11/86:40 am
DSM
- PHX
2 stops7h 55m
Southwest
Deal found 7/14![Southwest logo]()
$395
This Southwest deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2510:40 am
PHX
- DSM
2 stops9h 30m
Southwest
Mon 9/282:25 pm
DSM
- PHX
2 stops8h 05m
Southwest
Deal found 7/16![Southwest logo]()
$401
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2811:25 am
PHX
- DSM
2 stops7h 50m
Southwest
Mon 8/313:50 pm
DSM
- PHX
2 stops8h 05m
Southwest
Deal found 7/15![Southwest logo]()
$401
This Southwest deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/182:30 pm
PHX
- DSM
1 stop5h 15m
Southwest
Fri 11/201:50 pm
DSM
- PHX
Nonstop3h 00m
Southwest
Deal found 7/18![Southwest logo]()
$403
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/710:00 am
PHX
- DSM
2 stops9h 15m
Southwest
Mon 8/102:25 pm
DSM
- PHX
2 stops7h 30m
Southwest
Deal found 7/14![Southwest logo]()
$415
Last-minute flights from Mesa to Des MoinesDiscover last-minute flight deals from Mesa to Des Moines. Data last updated July 19, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to Des Moines. Data last updated July 19, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Mon 8/1010:06 pm
DSM
- PHX
1 stop16h 53m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Fri 8/79:21 pm
DSM
- PHX
1 stop16h 06m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Sun 8/99:44 pm
DSM
- PHX
1 stop15h 43m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$232
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/69:58 pm
PHX
- DSM
1 stop20h 33m
Multiple Airlines
Mon 8/1010:06 pm
DSM
- PHX
1 stop16h 53m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:45 am
PHX
- DSM
1 stop11h 09m
Multiple Airlines
Fri 8/1410:06 pm
DSM
- PHX
1 stop15h 21m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:45 am
PHX
- DSM
1 stop11h 09m
Multiple Airlines
Fri 8/79:21 pm
DSM
- PHX
1 stop16h 06m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/69:58 pm
PHX
- DSM
1 stop20h 33m
Multiple Airlines
Sun 8/99:44 pm
DSM
- PHX
1 stop15h 43m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$234
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:09 pm
PHX
- DSM
1 stop20h 51m
Multiple Airlines
Mon 8/248:38 pm
DSM
- PHX
1 stop18h 21m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$188
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/289:03 am
PHX
- DSM
1 stop7h 45m
Multiple Airlines
Sun 8/309:50 pm
DSM
- PHX
1 stop27h 34m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$224
One-way flights from Mesa to Des MoinesSearch for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated July 19, 2026.
Search for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated July 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:55 pm
PHX
- DSM
1 stop25h 11m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$77
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:05 am
PHX
- DSM
1 stop12h 01m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$78
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:30 am
PHX
- DSM
1 stop26h 27m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$84
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:30 pm
PHX
- DSM
1 stop10h 40m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$86
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:55 pm
PHX
- DSM
1 stop10h 02m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$93
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:55 pm
PHX
- DSM
1 stop20h 11m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$94
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:05 am
PHX
- DSM
1 stop12h 01m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1310:40 pm
PHX
- DSM
1 stop13h 12m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3010:55 pm
PHX
- DSM
1 stop18h 31m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$105
Find flight deals from Mesa to Des Moines
Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated July 19, 2026.
Round-trip from | $188 (Kiwi.com) |
|---|---|
One-way from | $77 (Kiwi.com) |
Popular in | July |
Cheapest in | November |
Average price | $429 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 19, 2026.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 11/7
10:00 am-5:23 pm
1 stop6h 23m
Des Moines
Sat 11/14
1:35 pm-6:09 pm
1 stop5h 34m
$336
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 8/15
12:25 pm-8:45 pm
1 stop6h 20m
Des Moines
Wed 8/19
6:10 am-12:30 pm
2 stops8h 20m
$346
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Wed 9/23
9:45 am-5:45 pm
1 stop6h 00m
Des Moines
Tue 9/29
6:10 am-11:00 am
1 stop6h 50m
$387
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 8/8
2:45 pm-11:00 pm
1 stop6h 15m
Des Moines
Sat 8/15
1:35 pm-5:10 pm
1 stop5h 35m
$387
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 8/8
12:25 pm-8:45 pm
1 stop6h 20m
Des Moines
Sat 8/15
7:20 am-12:35 pm
2 stops7h 15m
$392
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 11/7
7:05 am-1:40 pm
1 stop5h 35m
Des Moines
Sun 11/8
6:40 am-1:35 pm
2 stops7h 55m
$395
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Fri 9/25
10:40 am-10:10 pm
2 stops9h 30m
Des Moines
Mon 9/28
2:25 pm-8:30 pm
2 stops8h 05m
$401
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Fri 8/28
11:25 am-9:15 pm
2 stops7h 50m
Des Moines
Mon 8/31
3:50 pm-9:55 pm
2 stops8h 05m
$401
Quickest round-trip
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Wed 11/18
2:30 pm-8:45 pm
1 stop5h 15m
Des Moines
Fri 11/20
1:50 pm-3:50 pm
Nonstop3h 00m
$403
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Fri 8/7
10:00 am-9:15 pm
2 stops9h 15m
Des Moines
Mon 8/10
2:25 pm-7:55 pm
2 stops7h 30m
$415
Showing 1-10 of 21 resultsSorted by cheapest first
Best time to book a flight from Mesa to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
PHX-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Des Moines
MS9-DSM
PHX-DSM
What is the cheapest time of day to fly from MS9 to DSM?
Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 19, 2026.
It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 26% on the flight price compared to flying in the afternoon, which is usually more expensive.
Weekly flight availability from Mesa to Des Moines
Explore weekly flight availability from Mesa to Des Moines. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 19, 2026.
The most flights from MS9 to DSM are scheduled on a Monday (4 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (4 on average).
How much does it cost to fly round-trip from Mesa to Des Moines?
What is the cheapest day to fly from Mesa to Des Moines?
Use this chart to determine the cheapest time to fly round-trip from Mesa to Des Moines. Price data was last updated on July 18, 2026.
Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Saturday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated July 19, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAmerican Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Ames
Clive
Johnston
Boone
West Des Moines
Ankeny
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Top 5 airlines flying from Mesa to Des Moines
Discover the top 5 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$118 | Average$218 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$140 | Average$240 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$232 | Average$408 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$258 | Average$406 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$330 | Average$383 | FlexibilityNo cancel fee | On-time69% |