$71+ Cheap flights from Mesa, AZ to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/4. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Mar 6 — Mar 131
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Mesa to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in April or February, booked 79 days in advance, depart on a Tuesday or Wednesday and return on a Wednesday
Cheap flight deals from Mesa to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mesa to Des MoinesExplore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
This Frontier deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/261:22 pm
PHX
- DSM
1 stop4h 20m
Frontier
Mon 3/27:17 pm
DSM
- PHX
1 stop6h 24m
Frontier
Deal found 2/3![Frontier logo]()
$148
This Expedia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:50 am
PHX
- DSM
1 stop10h 26m
Frontier
Sat 3/212:56 pm
DSM
- PHX
Nonstop3h 20m
Frontier
Deal found 2/2![Frontier logo]()
$151
This Frontier deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/191:22 pm
PHX
- DSM
1 stop4h 25m
Frontier
Thu 2/267:27 pm
DSM
- PHX
1 stop6h 14m
Frontier
Deal found 2/1![Frontier logo]()
$164
This Expedia deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1311:17 am
PHX
- DSM
Nonstop2h 41m
Frontier
Mon 3/234:43 pm
DSM
- PHX
Nonstop3h 20m
Frontier
Deal found 2/1![Frontier logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/194:13 pm
PHX
- DSM
1 stop22h 11m
Multiple Airlines
Fri 3/68:21 pm
DSM
- PHX
1 stop19h 40m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$186
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/77:50 am
PHX
- DSM
1 stop10h 26m
Frontier
Mon 3/168:21 pm
DSM
- PHX
2 stops16h 38m
Frontier
Deal found 2/2![Frontier logo]()
$188
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/69:52 am
PHX
- DSM
1 stop8h 24m
Frontier
Mon 3/168:21 pm
DSM
- PHX
2 stops16h 38m
Frontier
Deal found 2/1![Frontier logo]()
$197
This Frontier deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:52 am
PHX
- DSM
1 stop9h 12m
Frontier
Mon 3/27:17 pm
DSM
- PHX
1 stop6h 24m
Frontier
Deal found 2/4![Frontier logo]()
$199
Best flights from Mesa to Des MoinesDiscover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
Discover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
This Frontier deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/261:22 pm
PHX
- DSM
1 stop4h 20m
Frontier
Mon 3/27:17 pm
DSM
- PHX
1 stop6h 24m
Frontier
Deal found 2/3![Frontier logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/194:13 pm
PHX
- DSM
1 stop22h 11m
Multiple Airlines
Fri 3/68:21 pm
DSM
- PHX
1 stop19h 40m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$186
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/114:30 pm
PHX
- DSM
1 stop5h 12m
United Airlines
Sat 3/215:04 pm
DSM
- PHX
1 stop7h 07m
United Airlines
Deal found 2/2![United Airlines logo]()
$289
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:55 pm
PHX
- DSM
1 stop8h 48m
Delta
Mon 5/182:39 pm
DSM
- PHX
1 stop7h 31m
Delta
Deal found 2/3![Delta logo]()
$299
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:50 am
PHX
- DSM
Nonstop2h 53m
American Airlines
Tue 11/105:10 am
DSM
- PHX
Nonstop3h 14m
American Airlines
Deal found 2/4![American Airlines logo]()
$304
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/73:35 pm
PHX
- DSM
Nonstop2h 40m
Southwest
Mon 3/162:15 pm
DSM
- PHX
Nonstop3h 05m
Southwest
Deal found 2/1![Southwest logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/287:06 pm
PHX
- DSM
1 stop22h 36m
Frontier
Sat 3/78:21 pm
DSM
- PHX
1 stop12h 21m
Frontier
Deal found 2/3![Frontier logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/159:24 pm
PHX
- DSM
1 stop19h 52m
Multiple Airlines
Sun 3/227:30 am
DSM
- PHX
1 stop28h 47m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$299
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:55 pm
PHX
- DSM
1 stop8h 48m
Delta
Fri 5/225:28 pm
DSM
- PHX
1 stop8h 04m
Delta
Deal found 2/2![Delta logo]()
$299
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/148:54 am
PHX
- DSM
Nonstop2h 53m
American Airlines
Sat 5/162:39 pm
DSM
- PHX
Nonstop3h 09m
American Airlines
Deal found 2/3![American Airlines logo]()
$304
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/69:08 am
PHX
- DSM
1 stop5h 02m
United Airlines
Fri 6/122:55 pm
DSM
- PHX
1 stop7h 47m
United Airlines
Deal found 2/2![United Airlines logo]()
$324
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/162:28 pm
PHX
- DSM
1 stop6h 31m
United Airlines
Tue 11/108:00 am
DSM
- PHX
1 stop6h 59m
United Airlines
Deal found 2/2![United Airlines logo]()
$324
Last-minute flights from Mesa to Des MoinesDiscover last-minute flight deals from Mesa to Des Moines. Data last updated February 4, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to Des Moines. Data last updated February 4, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/191:22 pm
PHX
- DSM
1 stop4h 25m
Frontier
Thu 2/267:27 pm
DSM
- PHX
1 stop6h 14m
Frontier
Deal found 2/1![Frontier logo]()
$164
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/194:13 pm
PHX
- DSM
1 stop22h 11m
Multiple Airlines
Fri 3/68:21 pm
DSM
- PHX
1 stop19h 40m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$186
This Frontier deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/261:22 pm
PHX
- DSM
1 stop4h 20m
Frontier
Mon 3/27:17 pm
DSM
- PHX
1 stop6h 24m
Frontier
Deal found 2/3![Frontier logo]()
$148
This Frontier deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:52 am
PHX
- DSM
1 stop9h 12m
Frontier
Mon 3/27:17 pm
DSM
- PHX
1 stop6h 24m
Frontier
Deal found 2/4![Frontier logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/69:52 am
PHX
- DSM
1 stop8h 24m
Frontier
Mon 3/168:21 pm
DSM
- PHX
2 stops16h 38m
Frontier
Deal found 2/1![Frontier logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/77:50 am
PHX
- DSM
1 stop10h 26m
Frontier
Mon 3/168:21 pm
DSM
- PHX
2 stops16h 38m
Frontier
Deal found 2/2![Frontier logo]()
$188
This Expedia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:50 am
PHX
- DSM
1 stop10h 26m
Frontier
Sat 3/212:56 pm
DSM
- PHX
Nonstop3h 20m
Frontier
Deal found 2/2![Frontier logo]()
$151
This Expedia deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1311:17 am
PHX
- DSM
Nonstop2h 41m
Frontier
Mon 3/234:43 pm
DSM
- PHX
Nonstop3h 20m
Frontier
Deal found 2/1![Frontier logo]()
$170
One-way flights from Mesa to Des MoinesSearch for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
Search for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:51 pm
PHX
- DSM
1 stop22h 51m
Frontier
Deal found 2/4![Frontier logo]()
$71
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/59:17 am
PHX
- DSM
1 stop8h 25m
Frontier
Deal found 2/4![Frontier logo]()
$77
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/269:17 am
PHX
- DSM
1 stop8h 25m
Frontier
Deal found 2/2![Frontier logo]()
$80
This Super.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/191:22 pm
PHX
- DSM
1 stop4h 25m
Frontier
Deal found 2/3![Frontier logo]()
$89
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:50 am
PHX
- DSM
1 stop4h 39m
Frontier
Deal found 2/2![Frontier logo]()
$90
This Super.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1311:17 am
PHX
- DSM
Nonstop2h 41m
Frontier
Deal found 2/2![Frontier logo]()
$93
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:40 am
PHX
- DSM
2 stops10h 36m
Frontier
Deal found 2/1![Frontier logo]()
$94
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/256:51 pm
PHX
- DSM
1 stop22h 51m
Frontier
Deal found 2/3![Frontier logo]()
$95
This Expedia deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:50 am
PHX
- DSM
1 stop10h 24m
Frontier
Deal found 2/3![Frontier logo]()
$96
This Trip.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:51 pm
PHX
- DSM
1 stop22h 56m
Frontier
Deal found 2/3![Frontier logo]()
$98
Find flight deals from Mesa to Des Moines
Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated February 4, 2026.
Round-trip from | $148 (Frontier) |
|---|---|
One-way from | $71 (Kiwi.com) |
Popular in | January |
Cheapest in | April |
Average price | $308 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.
Fly from
Mesa
Fly to
Des Moines
Route
Depart
Return
Price
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 2/26
1:22 pm-6:42 pm
1 stop4h 20m
Des Moines
Mon 3/2
7:17 pm-12:41 am
1 stop6h 24m
$148
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 2/19
4:13 pm-3:24 pm
1 stop22h 11m
Des Moines
Fri 3/6
8:21 pm-3:01 pm
1 stop19h 40m
$186
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 2/28
7:06 pm-6:42 pm
1 stop22h 36m
Des Moines
Sat 3/7
8:21 pm-7:42 am
1 stop12h 21m
$270
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Wed 3/11
4:30 pm-11:42 pm
1 stop5h 12m
Des Moines
Sat 3/21
5:04 pm-10:11 pm
1 stop7h 07m
$289
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 5/12
10:55 pm-9:43 am
1 stop8h 48m
Des Moines
Mon 5/18
2:39 pm-8:10 pm
1 stop7h 31m
$299
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sun 3/15
9:24 pm-7:16 pm
1 stop19h 52m
Des Moines
Sun 3/22
7:30 am-10:17 am
1 stop28h 47m
$299
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 5/12
10:55 pm-9:43 am
1 stop8h 48m
Des Moines
Fri 5/22
5:28 pm-11:32 pm
1 stop8h 04m
$299
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 4/16
8:50 am-1:43 pm
Nonstop2h 53m
Des Moines
Tue 11/10
5:10 am-7:24 am
Nonstop3h 14m
$304
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 5/14
8:54 am-1:47 pm
Nonstop2h 53m
Des Moines
Sat 5/16
2:39 pm-3:48 pm
Nonstop3h 09m
$304
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sat 3/7
3:35 pm-7:15 pm
Nonstop2h 40m
Des Moines
Mon 3/16
2:15 pm-3:20 pm
Nonstop3h 05m
$310
Showing 1-10 of 22 results
Best time to book a flight from Mesa to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
PHX-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Des Moines
MS9-DSM
PHX-DSM
How far ahead should I book a flight from Mesa to Des Moines?
Use this chart to determine the optimal time to book a round-trip flight from Mesa to Des Moines. Price data was last updated on January 30, 2026.
The price you pay for your flight from Mesa to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 78 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Mesa to Des Moines?
Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in March is currently the most expensive (average of $226). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MS9 to DSM?
Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 4, 2026.
It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 26% on the flight price compared to flying in the morning, which is usually more expensive.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated February 4, 2026.
Read reviews from past customers who have flown Southwest, United Airlines, and American Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Des Moines flight routes
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Mesa to Des Moines
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 4, 2026.
Search flights from Mesa to Des Moines by cabin class
Find flights from Mesa to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mesa and Des Moines flights
Browse other Mesa and Des Moines flight options. Last updated on February 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Mesa to Des Moines flights
Consider these flights traveling from Mesa to Des Moines.
Top 6 airlines flying from Mesa to Des Moines
Discover the top 6 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$67 | Average$196 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$90 | Average$208 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$164 | Average$307 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$220 | Average$377 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$222 | Average$362 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$275 | Average$383 | FlexibilityNo cancel fee | On-time69% |