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Des Moines

$44+ Cheap flights from Mesa, AZ to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/29. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in April or February, booked 79 days in advance, depart on a Tuesday or Saturday and return on a Wednesday

Find flight deals from Mesa to Des Moines

Cheapest flights from Mesa to Des Moines
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/410:26 pmPHX - DSM
1 stop19h 37mFrontier
Mon 12/87:58 pmDSM - PHX
1 stop20h 09mFrontier
Deal found 11/13$139
This Expedia deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/199:31 amPHX - DSM
1 stop9h 13mFrontier
Fri 1/98:25 pmDSM - PHX
1 stop5h 08mFrontier
Deal found 11/11$141
This Kiwi.com deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1110:26 pmPHX - DSM
1 stop19h 37mFrontier
Mon 12/157:58 pmDSM - PHX
1 stop5h 46mFrontier
Deal found 11/13$165
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:31 amPHX - DSM
1 stop9h 13mFrontier
Fri 1/28:29 pmDSM - PHX
1 stop19h 04mFrontier
Deal found 11/12$179
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1810:31 pmPHX - DSM
1 stop20h 13mFrontier
Tue 12/232:35 pmDSM - PHX
2 stops29h 32mFrontier
Deal found 11/11$192
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/217:00 amPHX - DSM
1 stop10h 38mMultiple Airlines
Mon 11/243:48 pmDSM - PHX
1 stop6h 50mMultiple Airlines
Deal found 11/12$214
This Frontier deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/217:00 amPHX - DSM
1 stop10h 38mFrontier
Fri 11/287:46 pmDSM - PHX
1 stop5h 46mFrontier
Deal found 11/13$218

Cheap flight deals from Mesa to Des Moines

Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated November 13, 2025.

Round-trip from

$139
(Kiwi.com)

One-way from

$44
(Trip.com)

Popular in

January

Cheapest in

April

Average price

$319
From Mesa to Des Moines
Search Deals
One-way flight from Mesa to Des Moines
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($72 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.

Fly from

Mesa

Fly to

Des Moines

Route

Depart

Return

Price

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 12/4

6:03 pm-7:03 pm

2 stops24h 00m

Des Moines

Mon 12/8

7:58 pm-12:44 am

1 stop5h 46m

$169

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Fri 12/19

9:31 am-7:44 pm

1 stop9h 13m

Des Moines

Fri 1/9

8:25 pm-7:20 pm

2 stops23h 55m

$180

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 12/11

10:26 pm-7:03 pm

1 stop19h 37m

Des Moines

Mon 12/15

7:58 pm-8:55 am

2 stops13h 57m

$196

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 12/18

10:31 pm-7:44 pm

1 stop20h 13m

Des Moines

Tue 12/23

2:35 pm-8:21 am

1 stop18h 46m

$210

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Mon 1/19

9:18 am-7:23 pm

1 stop9h 05m

Des Moines

Thu 1/22

7:00 am-12:50 pm

1 stop6h 50m

$214

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Sun 12/21

10:31 pm-7:44 pm

1 stop20h 13m

Des Moines

Wed 12/31

2:44 pm-12:53 pm

1 stop23h 09m

$278

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Sun 1/11

7:10 am-3:41 pm

1 stop7h 31m

Des Moines

Wed 1/21

12:25 pm-7:47 pm

1 stop8h 22m

$279

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Fri 12/12

1:00 pm-9:15 pm

1 stop7h 15m

Des Moines

Sun 12/14

6:50 am-2:00 pm

1 stop8h 10m

$279

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Fri 12/26

9:31 am-7:44 pm

1 stop9h 13m

Des Moines

Tue 12/30

11:14 am-11:49 pm

1 stop13h 35m

$292

PhoenixDes Moines

PHX - DSM

PHXDSM

Phoenix Sky Harbor Intl

Thu 12/4

1:30 pm-9:35 pm

1 stop7h 05m

Des Moines

Fri 12/5

8:20 am-2:05 pm

1 stop6h 45m

$293

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/11

Showing 1-10 of 20 results
1
2

Best time to book a flight from Mesa to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Des Moines

How far ahead should I book a flight from Mesa to Des Moines?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Des Moines. Price data was last updated on November 7, 2025.

The price you pay for your flight from Mesa to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 78 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Des Moines?

Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in March is currently the most expensive (average of $244). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to DSM?

Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 53% on the flight price compared to flying in the morning, which is usually more expensive.

What is the cheapest day to fly from Mesa to Des Moines?

Use this chart to determine the cheapest time to fly round-trip from Mesa to Des Moines. Price data was last updated on November 2, 2025.

Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Saturday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Mesa to Des Moines

Explore weekly flight availability from Mesa to Des Moines. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated November 13, 2025.

The most flights from MS9 to DSM are scheduled on a Thursday (7 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (4 on average).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated November 13, 2025.
Read reviews from past customers who have flown Southwest, Delta, and American Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,236 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,236 reviews
Southwest
8.0
Very good
4,236 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
8,007 reviews
Southwest
8.0
Very good
4,236 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,049 reviews
Southwest
8.0
Very good
4,236 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Allegiant Air
7.2
Good
698 reviews
Southwest
8.0
Very good
4,236 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Frontier
5.8
Fair
3,114 reviews
Southwest
8.0
Very good
4,236 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mesa?

    For a flight from Mesa to Des Moines, you will be flying into Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 5 inbound flights from Mesa per day. 6 airlines have flights to Des Moines from Mesa on a regular basis.

  • How long is the flight from Mesa to Des Moines?

    Frontier can get you from Mesa to Des Moines in just under 24h. Your travel time can differ by up to . Mesa and Des Moines are separated by a distance of 1147 mi.

  • What are the most reliable airlines from Mesa to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Mesa to Des Moines on time: SkyWest Airlines (89%), American Airlines (88%), Alaska Airlines (88%).

  • What are the cheapest flights from Mesa to Des Moines?

    While on average a flight from Mesa to Des Moines is generally $280, our data shows the cheapest flight currently is $88. When looking at the most popular route, (Phoenix Sky Harbor Intl - Des Moines), you can expect to pay $214 for that flight.

  • Can I find deals for flights from Mesa to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mesa to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Des Moines.

  • Can I find deals for business class flights from Mesa to Des Moines?

    Yes. Cheapflights offers flight deals from Mesa to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Des Moines?

    Currently, July is the cheapest month in which you can book a flight from Mesa to Des Moines (average of $113). Flying from Mesa to Des Moines in March is currently the most expensive (average of $244). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Top 6 airlines flying from Mesa to Des Moines

Discover the top 6 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$112Average$214FlexibilityNo cancel feeOn-time88%
FrontierCheapest$156Average$210FlexibilityNo cancel feeOn-time62%
DeltaCheapest$190Average$307FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$220Average$380FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$222Average$347FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$275Average$408FlexibilityNo cancel feeOn-time69%

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