$61+ Cheap flights from Mesa, AZ to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Sep 14 — Sep 211
Round-trip
1 adult, Economy
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Find cheap flights from Mesa to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in November or October, booked 65 days in advance, depart on a Wednesday or Monday and return on a Wednesday
Cheap flight deals from Mesa to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mesa to Des MoinesExplore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 15, 2026.
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:56 pm -
1 stop20h 37m
Sun 9/1311:29 am -
1 stop22h 31m
Deal found 8/10![Frontier logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:25 am -
1 stop11h 08m
Mon 9/148:30 pm -
1 stop25h 21m
Deal found 8/12![Frontier logo]()
$186
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:05 am -
1 stop5h 13m
Mon 10/122:31 pm -
1 stop18h 40m
Deal found 8/11![Frontier logo]()
$187
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1510:40 pm -
1 stop10h 17m
Mon 10/192:31 pm -
1 stop18h 40m
Deal found 8/11![Multiple Airlines logo]()
$188
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:00 am -
1 stop11h 06m
Mon 9/148:30 pm -
1 stop25h 21m
Deal found 8/12![Multiple Airlines logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:00 am -
1 stop11h 06m
Fri 9/118:30 pm -
1 stop13h 30m
Deal found 8/12![Multiple Airlines logo]()
$199
This CheapOair deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/178:56 pm -
1 stop20h 37m
Thu 9/2411:29 am -
1 stop14h 14m
Deal found 8/10![Frontier logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:25 am -
1 stop11h 08m
Sun 9/1311:29 am -
1 stop28h 48m
Deal found 8/12![Frontier logo]()
$201
This Super.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/103:21 pm -
1 stop26h 12m
Thu 9/1711:29 am -
1 stop4h 48m
Deal found 8/13![Frontier logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:25 am -
1 stop11h 08m
Mon 9/218:30 pm -
1 stop25h 21m
Deal found 8/11![Frontier logo]()
$211
Best flights from Mesa to Des MoinesDiscover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 15, 2026.
Discover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 15, 2026.
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/51:50 pm -
Nonstop2h 40m
Mon 10/127:10 pm -
1 stop5h 45m
Deal found 8/13![Southwest logo]()
$280
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1512:50 pm -
1 stop7h 27m
Tue 1/51:45 pm -
1 stop5h 27m
Deal found 8/14![United Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/712:50 am -
1 stop7h 21m
Sun 10/117:51 pm -
1 stop5h 30m
Deal found 8/12![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/152:20 pm -
1 stop5h 35m
Mon 10/192:00 pm -
Nonstop3h 05m
Deal found 8/11![Southwest logo]()
$280
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/165:34 pm -
1 stop5h 05m
Tue 1/59:09 am -
2 stops7h 45m
Deal found 8/14![United Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1812:15 pm -
2 stops7h 30m
Fri 11/201:50 pm -
Nonstop3h 00m
Deal found 8/10![Southwest logo]()
$312
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:50 pm -
Nonstop2h 40m
Sun 11/11:50 pm -
Nonstop3h 00m
Deal found 8/10![Southwest logo]()
$349
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/51:25 pm -
1 stop5h 25m
Wed 9/97:15 am -
2 stops7h 05m
Deal found 8/10![Southwest logo]()
$353
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:20 am -
1 stop6h 00m
Sun 10/182:15 pm -
Nonstop3h 05m
Deal found 8/13![Southwest logo]()
$359
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1410:40 am -
2 stops9h 35m
Sat 9/1912:10 pm -
1 stop8h 25m
Deal found 8/14![Southwest logo]()
$361
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:25 am -
2 stops7h 55m
Sat 9/127:20 am -
2 stops7h 20m
Deal found 8/12![Southwest logo]()
$368
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1411:55 am -
1 stop4h 55m
Tue 1/57:00 am -
2 stops8h 15m
Deal found 8/14![Southwest logo]()
$372
Last-minute flights from Mesa to Des MoinesDiscover last-minute flight deals from Mesa to Des Moines. Data last updated August 15, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to Des Moines. Data last updated August 15, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/22:04 pm -
2 stops27h 53m
Thu 9/1011:29 am -
1 stop28h 48m
Deal found 8/13![Multiple Airlines logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:10 am -
2 stops32h 47m
Thu 9/1011:29 am -
1 stop22h 31m
Deal found 8/13![Multiple Airlines logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:56 pm -
1 stop20h 37m
Sun 9/1311:29 am -
1 stop22h 31m
Deal found 8/10![Frontier logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:00 am -
1 stop11h 06m
Mon 9/148:30 pm -
1 stop25h 21m
Deal found 8/12![Multiple Airlines logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:00 am -
1 stop11h 06m
Fri 9/118:30 pm -
1 stop13h 30m
Deal found 8/12![Multiple Airlines logo]()
$199
This Super.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/103:21 pm -
1 stop26h 12m
Thu 9/1711:29 am -
1 stop4h 48m
Deal found 8/13![Frontier logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:00 am -
1 stop11h 06m
Sun 9/131:58 pm -
2 stops25h 08m
Deal found 8/14![Multiple Airlines logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:25 am -
1 stop11h 08m
Mon 9/148:30 pm -
1 stop25h 21m
Deal found 8/12![Frontier logo]()
$186
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:25 am -
1 stop11h 08m
Sun 9/1311:29 am -
1 stop28h 48m
Deal found 8/12![Frontier logo]()
$201
This CheapOair deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/178:56 pm -
1 stop20h 37m
Thu 9/2411:29 am -
1 stop14h 14m
Deal found 8/10![Frontier logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:25 am -
1 stop11h 08m
Mon 9/218:30 pm -
1 stop25h 21m
Deal found 8/11![Frontier logo]()
$211
One-way flights from Mesa to Des MoinesSearch for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated August 15, 2026.
Search for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated August 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:56 pm -
1 stop11h 48m
Deal found 8/11![Frontier logo]()
$61
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/98:56 pm -
1 stop11h 48m
Deal found 8/11![Frontier logo]()
$72
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:29 am -
1 stop6h 04m
Deal found 8/11![Frontier logo]()
$80
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:56 pm -
1 stop11h 48m
Deal found 8/11![Frontier logo]()
$84
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/123:21 pm -
1 stop17h 23m
Deal found 8/11![Frontier logo]()
$86
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:56 pm -
1 stop20h 37m
Deal found 8/11![Frontier logo]()
$87
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:25 am -
1 stop11h 08m
Deal found 8/12![Frontier logo]()
$93
This Frontier deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:05 am -
1 stop5h 13m
Deal found 8/11![Frontier logo]()
$95
Find flight deals from Mesa to Des Moines
Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated August 15, 2026.
Round-trip from | $184 (Kiwi.com) |
|---|---|
One-way from | $61 (Kiwi.com) |
Popular in | July |
Cheapest in | November |
Average price | $402 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 15, 2026.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Mon 10/5
1:50 pm-6:30 pm
Nonstop2h 40m
Des Moines
Mon 10/12
7:10 pm-10:55 pm
1 stop5h 45m
$280
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Thu 10/15
2:20 pm-9:55 pm
1 stop5h 35m
Des Moines
Mon 10/19
2:00 pm-3:05 pm
Nonstop3h 05m
$280
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Wed 11/18
12:15 pm-8:45 pm
2 stops7h 30m
Des Moines
Fri 11/20
1:50 pm-3:50 pm
Nonstop3h 00m
$312
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Tue 12/15
12:50 pm-9:17 pm
1 stop7h 27m
Des Moines
Tue 1/5
1:45 pm-6:12 pm
1 stop5h 27m
$317
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Wed 12/16
5:34 pm-11:39 pm
1 stop5h 05m
Des Moines
Tue 1/5
9:09 am-3:54 pm
2 stops7h 45m
$337
Quickest round-trip
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Fri 10/30
1:50 pm-6:30 pm
Nonstop2h 40m
Des Moines
Sun 11/1
1:50 pm-3:50 pm
Nonstop3h 00m
$349
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Sat 9/5
1:25 pm-8:50 pm
1 stop5h 25m
Des Moines
Wed 9/9
7:15 am-12:20 pm
2 stops7h 05m
$353
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Thu 10/15
5:20 am-1:20 pm
1 stop6h 00m
Des Moines
Sun 10/18
2:15 pm-3:20 pm
Nonstop3h 05m
$359
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Mon 9/14
10:40 am-10:15 pm
2 stops9h 35m
Des Moines
Sat 9/19
12:10 pm-6:35 pm
1 stop8h 25m
$361
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Thu 9/10
11:25 am-9:20 pm
2 stops7h 55m
Des Moines
Sat 9/12
7:20 am-12:40 pm
2 stops7h 20m
$368
Showing 1-10 of 23 resultsSorted by cheapest first
Best time to book a flight from Mesa to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
PHX-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Des Moines
MS9-DSM
PHX-DSM
What is the cheapest time of day to fly from MS9 to DSM?
Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 15, 2026.
It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 30% on the flight price compared to flying in the afternoon, which is usually more expensive.
How much does it cost to fly round-trip from Mesa to Des Moines?
Airfare is below average for this route at the moment.
Mesa to Des Moines flights typically cost between $368 and $497 in September.The cheapest round-trip price found within the last 5 days was $184 on Frontier (Sep 10-Sep 13).
What is the cheapest day to fly from Mesa to Des Moines?
Use this chart to determine the cheapest time to fly round-trip from Mesa to Des Moines. Price data was last updated on August 8, 2026.
Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Saturday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated August 15, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAmerican Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Overall
8.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Overall
8.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Overall
8.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Overall
8.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Overall
8.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
Boone
Norwalk
West Des Moines
Ankeny
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Top 5 airlines flying from Mesa to Des Moines
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$118 | Average$213 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$140 | Average$240 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$232 | Average$419 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$254 | Average$409 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$318 | Average$383 | FlexibilityNo cancel fee | On-time69% |