$79+ Cheap flights from Mesa, AZ to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Oct 1 — Oct 81
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Mesa to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in November or October, booked 65 days in advance, depart on a Wednesday or Saturday and return on a Wednesday
Cheap flight deals from Mesa to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mesa to Des MoinesExplore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 1, 2026.
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:16 am -
1 stop12h 34m
Mon 10/269:11 pm -
1 stop22h 15m
Deal found 8/26![Multiple Airlines logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:24 pm -
1 stop13h 33m
Mon 10/58:30 pm -
1 stop19h 47m
Deal found 8/26![Multiple Airlines logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:24 pm -
1 stop13h 33m
Sun 10/41:22 pm -
1 stop25h 00m
Deal found 8/26![Multiple Airlines logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:21 am -
2 stops27h 31m
Sun 10/47:00 am -
1 stop29h 54m
Deal found 8/29![Multiple Airlines logo]()
$246
This Frontier deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/259:15 am -
1 stop8h 18m
Mon 9/288:30 pm -
1 stop5h 13m
Deal found 8/27![Frontier logo]()
$254
This Super.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/88:51 pm -
1 stop20h 39m
Mon 10/128:25 pm -
1 stop5h 23m
Deal found 8/28![Frontier logo]()
$256
This Expedia deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:29 am -
1 stop6h 04m
Fri 9/258:30 pm -
1 stop19h 47m
Deal found 8/27![Frontier logo]()
$259
This Frontier deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:29 am -
1 stop6h 04m
Mon 9/148:30 pm -
1 stop5h 13m
Deal found 8/28![Frontier logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:21 am -
2 stops27h 31m
Mon 10/58:30 pm -
1 stop13h 30m
Deal found 8/29![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:25 am -
1 stop11h 08m
Mon 9/289:31 pm -
1 stop16h 28m
Deal found 8/27![Multiple Airlines logo]()
$262
This CheapOair deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/203:21 pm -
1 stop26h 12m
Thu 9/2411:29 am -
1 stop14h 14m
Deal found 8/26![Frontier logo]()
$264
Best flights from Mesa to Des MoinesDiscover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 1, 2026.
Discover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 1, 2026.
This Southwest deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:45 am -
2 stops7h 30m
Sat 10/242:30 pm -
2 stops8h 30m
Deal found 8/27![Southwest logo]()
$383
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:20 am -
1 stop4h 50m
Tue 1/51:45 pm -
1 stop5h 27m
Deal found 8/30![United Airlines logo]()
$422
This Delta deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3011:05 pm -
1 stop8h 33m
Sat 10/34:20 pm -
1 stop5h 54m
Deal found 8/29![Delta logo]()
$427
This Southwest deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/211:35 pm -
Nonstop2h 40m
Fri 11/271:50 pm -
Nonstop3h 00m
Deal found 8/29![Southwest logo]()
$410
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1010:55 am -
1 stop4h 05m
Wed 12/161:23 pm -
1 stop5h 09m
Deal found 8/31![United Airlines logo]()
$425
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/161:50 pm -
Nonstop2h 40m
Mon 10/192:00 pm -
Nonstop3h 05m
Deal found 8/31![Southwest logo]()
$413
This Southwest deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/81:50 pm -
Nonstop2h 40m
Thu 10/152:00 pm -
Nonstop3h 05m
Deal found 8/30![Southwest logo]()
$431
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/221:15 pm -
1 stop5h 50m
Fri 9/255:40 am -
1 stop7h 05m
Deal found 8/31![Southwest logo]()
$433
This Southwest deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:00 am -
1 stop4h 20m
Sat 10/171:20 pm -
2 stops8h 50m
Deal found 8/28![Southwest logo]()
$435
This Southwest deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/159:20 am -
2 stops7h 30m
Tue 1/53:30 pm -
2 stops8h 05m
Deal found 8/30![Southwest logo]()
$437
Last-minute flights from Mesa to Des MoinesDiscover last-minute flight deals from Mesa to Des Moines. Data last updated September 1, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to Des Moines. Data last updated September 1, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:29 am -
1 stop6h 04m
Fri 9/258:30 pm -
1 stop19h 47m
Deal found 8/27![Frontier logo]()
$259
This Frontier deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:29 am -
1 stop6h 04m
Mon 9/148:30 pm -
1 stop5h 13m
Deal found 8/28![Frontier logo]()
$260
This Super.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/123:21 pm -
1 stop17h 23m
Mon 9/148:30 pm -
1 stop5h 13m
Deal found 8/28![Frontier logo]()
$266
This CheapOair deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/169:15 am -
1 stop23h 29m
Mon 9/218:30 pm -
1 stop5h 13m
Deal found 8/27![Frontier logo]()
$265
This CheapOair deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/163:21 pm -
1 stop17h 23m
Sun 9/2011:29 am -
1 stop22h 31m
Deal found 8/29![Frontier logo]()
$269
This CheapOair deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/203:21 pm -
1 stop26h 12m
Thu 9/2411:29 am -
1 stop14h 14m
Deal found 8/26![Frontier logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:25 am -
1 stop11h 08m
Mon 9/289:31 pm -
1 stop16h 28m
Deal found 8/27![Multiple Airlines logo]()
$262
This CheapOair deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/248:56 pm -
1 stop20h 37m
Sun 9/2711:29 am -
1 stop22h 31m
Deal found 8/29![Frontier logo]()
$268
This Frontier deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/259:15 am -
1 stop8h 18m
Mon 9/288:30 pm -
1 stop5h 13m
Deal found 8/27![Frontier logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:21 am -
2 stops27h 31m
Sun 10/47:00 am -
1 stop29h 54m
Deal found 8/29![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:21 am -
2 stops27h 31m
Mon 10/58:30 pm -
1 stop13h 30m
Deal found 8/29![Multiple Airlines logo]()
$261
One-way flights from Mesa to Des MoinesSearch for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 1, 2026.
Search for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:39 pm -
1 stop15h 13m
Deal found 8/27![Multiple Airlines logo]()
$79
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:24 pm -
1 stop13h 33m
Deal found 8/27![Multiple Airlines logo]()
$80
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:30 am -
1 stop13h 20m
Deal found 8/28![Multiple Airlines logo]()
$85
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:21 pm -
1 stop17h 31m
Deal found 8/28![Multiple Airlines logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:59 pm -
1 stop14h 57m
Deal found 8/29![Frontier logo]()
$111
Find flight deals from Mesa to Des Moines
Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated September 1, 2026.
Round-trip from | $195 (Kiwi.com) |
|---|---|
One-way from | $79 (Kiwi.com) |
Popular in | July |
Cheapest in | November |
Average price | $433 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 1, 2026.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Sat 10/17
7:45 am-5:15 pm
2 stops7h 30m
Des Moines
Sat 10/24
2:30 pm-9:00 pm
2 stops8h 30m
$383
Quickest round-trip
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Sat 11/21
1:35 pm-5:15 pm
Nonstop2h 40m
Des Moines
Fri 11/27
1:50 pm-3:50 pm
Nonstop3h 00m
$410
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Fri 10/16
1:50 pm-6:30 pm
Nonstop2h 40m
Des Moines
Mon 10/19
2:00 pm-3:05 pm
Nonstop3h 05m
$413
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Tue 12/15
6:20 am-12:10 pm
1 stop4h 50m
Des Moines
Tue 1/5
1:45 pm-6:12 pm
1 stop5h 27m
$422
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Thu 12/10
10:55 am-4:00 pm
1 stop4h 05m
Des Moines
Wed 12/16
1:23 pm-5:32 pm
1 stop5h 09m
$425
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Wed 9/30
11:05 pm-9:38 am
1 stop8h 33m
Des Moines
Sat 10/3
4:20 pm-8:14 pm
1 stop5h 54m
$427
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Thu 10/8
1:50 pm-6:30 pm
Nonstop2h 40m
Des Moines
Thu 10/15
2:00 pm-3:05 pm
Nonstop3h 05m
$431
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Tue 9/22
1:15 pm-9:05 pm
1 stop5h 50m
Des Moines
Fri 9/25
5:40 am-10:45 am
1 stop7h 05m
$433
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Fri 10/9
7:00 am-1:20 pm
1 stop4h 20m
Des Moines
Sat 10/17
1:20 pm-8:10 pm
2 stops8h 50m
$435
PhoenixDes Moines
PHX Phoenix Sky Harbor Intl - DSM Des Moines
PHXDSM
Phoenix Sky Harbor Intl
Tue 12/15
9:20 am-5:50 pm
2 stops7h 30m
Des Moines
Tue 1/5
3:30 pm-10:35 pm
2 stops8h 05m
$437
Showing 1-10 of 20 resultsSorted by cheapest first
Best time to book a flight from Mesa to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
PHX-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Des Moines
MS9-DSM
PHX-DSM
What is the cheapest time of day to fly from MS9 to DSM?
Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 1, 2026.
It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 30% on the flight price compared to flying in the afternoon, which is usually more expensive.
Weekly flight availability from Mesa to Des Moines
Explore weekly flight availability from Mesa to Des Moines. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 1, 2026.
The most flights from MS9 to DSM are scheduled on a Monday (3 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (2 on average).
How much does it cost to fly round-trip from Mesa to Des Moines?
Airfare is below average for this route at the moment.
Mesa to Des Moines flights typically cost between $369 and $542 in October.The cheapest round-trip price found within the last 5 days was $195 on Multiple Airlines (Oct 22-Oct 26).
What is the cheapest day to fly from Mesa to Des Moines?
Use this chart to determine the cheapest time to fly round-trip from Mesa to Des Moines. Price data was last updated on August 29, 2026.
Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Saturday evenings when fares are most often at their lowest. Friday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 1, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAmerican Airlines from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
Boone
Norwalk
West Des Moines
Ankeny
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Des Moines flight routes
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Mesa to Des Moines
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 1, 2026.
Search flights from Mesa to Des Moines by cabin class
Find flights from Mesa to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mesa and Des Moines flights
Browse other Mesa and Des Moines flight options. Last updated on September 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Mesa to Des Moines flights
Consider these flights traveling from Mesa to Des Moines.
Top 5 airlines flying from Mesa to Des Moines
Discover the top 5 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$118 | Average$228 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$139 | Average$241 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$239 | Average$419 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$261 | Average$418 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$318 | Average$386 | FlexibilityNo cancel fee | On-time69% |