$85+ Cheap flights from Mesa, AZ to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/4. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — DSM
Jul 10 — Jul 171
Round-trip
1 adult, Economy
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Find cheap flights from Mesa to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Des Moines are usually found in November or October, booked 65 days in advance, depart on a Saturday or Wednesday and return on a Wednesday
Cheap flight deals from Mesa to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mesa to Des MoinesExplore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
Explore the most affordable flight options available from Mesa to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Mon 8/1010:06 pm
DSM
- PHX
1 stop16h 53m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:27 pm
PHX
- DSM
1 stop20h 33m
Multiple Airlines
Mon 8/248:38 pm
DSM
- PHX
1 stop16h 46m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$178
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:04 pm
PHX
- DSM
1 stop28h 50m
Multiple Airlines
Mon 8/1010:06 pm
DSM
- PHX
1 stop16h 53m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$188
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Fri 8/79:21 pm
DSM
- PHX
1 stop16h 06m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$196
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:55 pm
PHX
- DSM
1 stop19h 46m
Multiple Airlines
Mon 9/149:31 pm
DSM
- PHX
1 stop21h 19m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:45 am
PHX
- DSM
1 stop11h 09m
Multiple Airlines
Mon 8/1010:06 pm
DSM
- PHX
1 stop16h 53m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:04 pm
PHX
- DSM
1 stop28h 50m
Multiple Airlines
Fri 8/79:21 pm
DSM
- PHX
1 stop16h 06m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/222:04 pm
PHX
- DSM
1 stop28h 39m
Multiple Airlines
Fri 7/3110:01 pm
DSM
- PHX
1 stop15h 26m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Sun 8/97:00 am
DSM
- PHX
1 stop10h 53m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$245
Best flights from Mesa to Des MoinesDiscover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
Discover carefully curated flight deals from Mesa to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:20 am
PHX
- DSM
2 stops7h 25m
Southwest
Thu 8/203:50 pm
DSM
- PHX
1 stop7h 40m
Southwest
Deal found 6/9![Southwest logo]()
$305
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:48 pm
PHX
- DSM
1 stop6h 08m
United Airlines
Sat 7/46:00 am
DSM
- PHX
1 stop8h 26m
United Airlines
Deal found 6/7![United Airlines logo]()
$427
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1111:35 am
PHX
- DSM
2 stops8h 20m
Southwest
Thu 8/133:50 pm
DSM
- PHX
2 stops8h 05m
Southwest
Deal found 6/9![Southwest logo]()
$311
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/711:00 am
PHX
- DSM
2 stops8h 45m
Southwest
Thu 8/65:40 am
DSM
- PHX
2 stops8h 10m
Southwest
Deal found 6/9![Southwest logo]()
$370
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/189:00 am
PHX
- DSM
1 stop6h 18m
United Airlines
Wed 8/191:35 pm
DSM
- PHX
2 stops9h 02m
United Airlines
Deal found 6/9![United Airlines logo]()
$438
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1311:25 am
PHX
- DSM
2 stops7h 50m
Southwest
Mon 8/175:40 am
DSM
- PHX
2 stops8h 10m
Southwest
Deal found 6/9![Southwest logo]()
$401
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/172:20 pm
PHX
- DSM
1 stop4h 55m
Southwest
Thu 8/203:50 pm
DSM
- PHX
2 stops8h 05m
Southwest
Deal found 6/5![Southwest logo]()
$414
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/610:40 am
PHX
- DSM
2 stops9h 30m
Southwest
Sat 8/87:20 am
DSM
- PHX
2 stops8h 50m
Southwest
Deal found 6/8![Southwest logo]()
$429
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:40 am
PHX
- DSM
1 stop6h 25m
Southwest
Sat 7/45:10 am
DSM
- PHX
2 stops9h 35m
Southwest
Deal found 6/7![Southwest logo]()
$436
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/54:15 pm
PHX
- DSM
1 stop4h 20m
Southwest
Sun 7/124:15 pm
DSM
- PHX
2 stops10h 00m
Southwest
Deal found 6/5![Southwest logo]()
$444
Last-minute flights from Mesa to Des MoinesDiscover last-minute flight deals from Mesa to Des Moines. Data last updated June 10, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to Des Moines. Data last updated June 10, 2026 and is based on user searches.
This Super.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/266:40 am
PHX
- DSM
1 stop4h 51m
Frontier
Wed 7/12:16 pm
DSM
- PHX
1 stop19h 29m
Frontier
Deal found 6/9![Frontier logo]()
$266
This Expedia deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/296:40 am
PHX
- DSM
1 stop4h 51m
Frontier
Mon 7/62:19 pm
DSM
- PHX
1 stop21h 52m
Frontier
Deal found 6/7![Frontier logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:45 am
PHX
- DSM
1 stop11h 26m
Multiple Airlines
Mon 7/610:01 pm
DSM
- PHX
1 stop16h 58m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$286
This Expedia deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:53 pm
PHX
- DSM
1 stop16h 41m
Frontier
Fri 7/102:19 pm
DSM
- PHX
1 stop27h 24m
Frontier
Deal found 6/5![Frontier logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/79:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Thu 8/67:00 am
DSM
- PHX
1 stop10h 53m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/72:04 pm
PHX
- DSM
1 stop20h 55m
Multiple Airlines
Sun 7/199:33 pm
DSM
- PHX
1 stop15h 54m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$281
This Priceline deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:40 am
PHX
- DSM
1 stop4h 54m
Frontier
Mon 7/202:19 pm
DSM
- PHX
1 stop9h 09m
Frontier
Deal found 6/8![Frontier logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/222:04 pm
PHX
- DSM
1 stop28h 39m
Multiple Airlines
Fri 7/3110:01 pm
DSM
- PHX
1 stop15h 26m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$241
This Super.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:40 am
PHX
- DSM
1 stop4h 54m
Frontier
Mon 8/32:19 pm
DSM
- PHX
1 stop9h 09m
Frontier
Deal found 6/6![Frontier logo]()
$285
One-way flights from Mesa to Des MoinesSearch for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
Search for one-way flight options from Mesa to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:58 pm
PHX
- DSM
1 stop13h 01m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$85
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/59:58 pm
PHX
- DSM
1 stop20h 56m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3010:32 pm
PHX
- DSM
1 stop12h 27m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/72:04 pm
PHX
- DSM
1 stop20h 55m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$119
This Expedia deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:19 am
PHX
- DSM
1 stop24h 15m
Frontier
Deal found 6/7![Frontier logo]()
$121
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/89:58 pm
PHX
- DSM
1 stop20h 45m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:27 pm
PHX
- DSM
1 stop20h 44m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/32:16 pm
PHX
- DSM
2 stops44h 43m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$128
Find flight deals from Mesa to Des Moines
Keep the following information in mind while searching for Mesa to Des Moines flight deals. Data was last updated June 10, 2026.
Round-trip from | $162 (Kiwi.com) |
|---|---|
One-way from | $85 (Kiwi.com) |
Popular in | July |
Cheapest in | November |
Average price | $395 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from Mesa to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 8/18
8:20 am-5:45 pm
2 stops7h 25m
Des Moines
Thu 8/20
3:50 pm-9:30 pm
1 stop7h 40m
$305
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 8/11
11:35 am-9:55 pm
2 stops8h 20m
Des Moines
Thu 8/13
3:50 pm-9:55 pm
2 stops8h 05m
$311
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 7/7
11:00 am-9:45 pm
2 stops8h 45m
Des Moines
Thu 8/6
5:40 am-11:50 am
2 stops8h 10m
$370
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 8/13
11:25 am-9:15 pm
2 stops7h 50m
Des Moines
Mon 8/17
5:40 am-11:50 am
2 stops8h 10m
$401
Quickest round-trip
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Mon 8/17
2:20 pm-9:15 pm
1 stop4h 55m
Des Moines
Thu 8/20
3:50 pm-9:55 pm
2 stops8h 05m
$414
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Wed 7/1
2:48 pm-10:56 pm
1 stop6h 08m
Des Moines
Sat 7/4
6:00 am-12:26 pm
1 stop8h 26m
$427
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Thu 8/6
10:40 am-10:10 pm
2 stops9h 30m
Des Moines
Sat 8/8
7:20 am-2:10 pm
2 stops8h 50m
$429
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Wed 7/1
6:40 am-3:05 pm
1 stop6h 25m
Des Moines
Sat 7/4
5:10 am-12:45 pm
2 stops9h 35m
$436
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Tue 8/18
9:00 am-5:18 pm
1 stop6h 18m
Des Moines
Wed 8/19
1:35 pm-8:37 pm
2 stops9h 02m
$438
PhoenixDes Moines
PHX - DSM
PHXDSM
Phoenix Sky Harbor Intl
Sun 7/5
4:15 pm-10:35 pm
1 stop4h 20m
Des Moines
Sun 7/12
4:15 pm-12:15 am
2 stops10h 00m
$444
Showing 1-10 of 20 resultsSorted by cheapest first
Best time to book a flight from Mesa to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mesa with our price prediction graph.
PHX-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Des Moines
MS9-DSM
PHX-DSM
What is the cheapest time of day to fly from MS9 to DSM?
Find hourly flight availability from Mesa to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 10, 2026.
It’s typically best to fly out from Mesa to Des Moines in the evening. Doing so could potentially save you 24% on the flight price compared to flying in the morning, which is usually more expensive.
Weekly flight availability from Mesa to Des Moines
Explore weekly flight availability from Mesa to Des Moines. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 10, 2026.
The most flights from MS9 to DSM are scheduled on a Monday (4 on average). You will have fewer flight options on Sunday, which is when the least amount of flights are scheduled (2 on average).
How much does it cost to fly round-trip from Mesa to Des Moines?
What is the cheapest day to fly from Mesa to Des Moines?
Use this chart to determine the cheapest time to fly round-trip from Mesa to Des Moines. Price data was last updated on June 8, 2026.
Travelers seeking maximum savings on their Mesa to Des Moines flight should consider departing on Saturday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated June 10, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAllegiant Air from Mesa to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
7.9
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
7.9
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
7.9
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
7.9
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
7.9
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
7.9
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Mesa to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Ames
Johnston
Clive
Boone
West Des Moines
Ankeny
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Top 5 airlines flying from Mesa to Des Moines
Discover the top 5 airlines that operate flights from Mesa to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$112 | Average$221 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$118 | Average$228 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$232 | Average$402 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$245 | Average$401 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$275 | Average$376 | FlexibilityNo cancel fee | On-time69% |